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Complete Genome Characterizations Of Two Novel Mitoviruses Hosted By The Hypogeous, Mycorrhizal Fungi Statesia Pompholyx And Tuber Sp., Ilgaz Akata, Gülce Edi̇ş, Eda Kumru, Emre Keski̇n, Ergi̇n Şahi̇n

Turkish Journal of Botany

The study of viral diversity in uncultivated fungi, including those involved in mycorrhizal relationships, alongside research on viral communities in phytopathogenic and economically important fungi, is crucial for a comprehensive understanding of mycovirus diversity and evolution. Mycorrhizal fungi host various viruses, contributing to our understanding of virus diversity and evolution. Here, we report on the identification and complete genome characterization of two novel mitoviruses that naturally infect the hypogeous, mycorrhizal fungi Statesia pompholyx and Tuber sp. The identified viruses, denominated as “Statesia pompholyx mitovirus 1” (SpMV1) and Tuber mitovirus 3 (TruMV3), have genome lengths of 2549 and 3292 nucleotides and …

Determining The Optimal Antioxidant Strategy: A Comparative Analysis Of Extractionmethods In Cistus Villosus L. Extracts Revealed By Lc-Hrms And Computationalmodeling, Hicham Bouakkaz, Ebru Erol, Khedidja Benarous, Gülaçti Topçu, Reguia Mahfoudi, Amar Djeridane, Mohamed Yousfi

Turkish Journal of Biology

Background/aim: Cistus villosus L., a beloved tea herb, contains a treasure trove of potent antioxidants. Our research unveils thisancient ally’s potential to shield against oxidative stress, a modern health threat.Materials and methods: Antioxidant assays were conducted to evaluate the potency of ethyl acetate extract. IC50 values were determinedfor the extract in various antioxidant assays. Furthermore, molecular docking was employed for the examination of the 22 compoundsanalyzed through LC-HRMS. Additionally, ADMET and PASS investigations were conducted to evaluate their capability as antioxidantsand inhibitors of oxidant formation.Results: Each identified compound boasts a history of antioxidant prowess, building the natural defense arsenal of …

Enhanced Formulation And Comprehensive Analysis Of Novel Natural Ointments Withgrape Seed And Pomegranate Peel Infused In Olive Oil, Mebarka Imane Benguechoua, Madjda Benguechoua, Khedidja Benarous, Alaeddine Kaouka, Mohamed Yousfi

Turkish Journal of Biology

Background/aim: The global shift toward sustainable and organic alternatives in cosmetics and personal care has created a demandfor innovative and environmentally conscious formulations. This study aimed to develop novel natural ointments using beeswax andgrape seed (GS) and pomegranate peel (PP) extracts infused in extra virgin olive oil (EVOO), and determine the physicochemicalcharacteristics, microbiological properties, and antioxidant activity as a way to valorize organic waste toward its application in thecosmetic industry. The research aimed to promote sustainability and effectiveness in the cosmetic industry.Materials and methods: Microbial analysis was performed on the oils and ointments, followed by the extraction of active compoundsusing …

Investigating The Composition Of Fatty Acid, Tocopherol, And Sterol Contents Andantioxidant Capacity Of Oils From The Seeds Of Abelmoschus Esculentus L. Growing Inalgeria, Samira Nia, Madjda Benguechoua, Toufik Hadj Mahammed, Khatir Reggagui, Mohamed Yousfi

Turkish Journal of Biology

Background/aim: Vegetable oils are considered a vital source of energy when glucose cannot be utilized. Therefore, research on newsources of oil that demonstrate nutritional value is necessary. Okra (Abelmoschus esculentus), a member of the Malvaceae family, isa remarkable botanical specimen due to its various uses; its roots, stem, leaves, fruits, and seeds are all valued for their nutritional,therapeutic, and industrial value. This study aims to demonstrate okra’s fatty acid (FA) composition, tocopherol content, and sterolcontent and evaluate the antioxidant activity of the oils extracted from okra using three solvents.Materials and methods: The initial part of this study involved oil extraction …

Evaluating The Multifaceted Bioactivity Of Syzygium Aromaticum Essential Oil:The Central Role Of Eugenol, Noureddine Rahim, Chamseddine Derabli, Amina Bramki, Sara Mahdjoub, Sandrine Rup-Jacques, Ghozlane Barboucha, Stephani Hesse, Houssem Boulebd

Turkish Journal of Biology

Background/aim: Syzygium aromaticum L. is a versatile plant traditionally used to treat digestive and respiratory issues, improve oral health, and relieve pain, particularly in regions such as Southeast Asia, South Asia, and parts of the Middle East. Its essential oil (EO), predominantly composed of eugenol, is rich in bioactive compounds. This study aims to clarify the specific contribution of eugenol to the antioxidant, antibacterial, antifungal, and insecticidal activities of S. aromaticum EO by comparing their individual effects. Additionally, density functional theory (DFT) calculations were employed to examine the antioxidant mechanism of eugenol and its role in enhancing the overall activity …

Metal Complexes Of Sulfamethazine/Benzoin-Based Schiff Base Ligand: Synthesis,Characterization, Dft Calculations, And Antimicrobial Activities, Kerem Buran

Turkish Journal of Biology

Background/aim: The global rise in bacterial resistance poses a significant challenge, exacerbated by the overuse of antibacterial agents. Schiff base-metal complexes have gained attention for their potential antimicrobial properties, attributed to their unique three-dimensional structures and modes of action, such as cell wall inhibition and membrane disruption. The aim of this study was to synthesize and characterize a novel Schiff base (L) derived from sulfamethazine and benzoin, and to develop metal complexes of it with Cu2+, Co2+, Ni2+, and Cd2+. This research sought to evaluate the antibacterial and antifungal activities of the synthesized Schiff base and its metal complexes to …

Antidiabetic Potential Of Polysaccharides From Algerian Saharan Zygophyllum Geslini Instreptozotocin-Induced Diabetic Rats, Houria Medjdoub, Waffa Bouali, Arezki Azzi, Nacera Belkacem, Nabila Benariba, Nawel Meliani

Turkish Journal of Biology

Background/aim: Zygophyllum geslini, an endemic Algerian species, has numerous properties, especially as an antidiabeticdrug. In Algeria, this herb serves as condiment in Saharan dishes and as animal feed (Sheep, Goat and Camel). However, fewscientific studies have reported on the medicinal properties of this Saharan species. The aims of the present work were to study 1) thechemical aspects of polysaccharides extracted from this plant, 2) their inhibitory effect on pancreatic α-amylase in vitro, and 3) theirantihyperglycemic effect in streptozotocin-induced diabetic rats in vivo.Materials and methods: First, polysaccharides were extracted from Z. geslini aerial part (ZGAP) in hot water and precipitated withethanol …

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Turkish Journal of Biology

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Phytochemical Analysis And Antioxidant, Antimicrobial, And Cytotoxic Activities Ofxanthium Strumarium L. (Asteraceae), Ahmet Beyatli

Turkish Journal of Biology

Background/aim: Medicinal plants are considered an important source of novel antioxidant, antimicrobial, and anticancer agents. The main goal of this study was to define the beneficial properties of various extracts obtained from Xanthium strumarium. Materials and methods: Evaluations were conducted on the total phenolic and flavonoid contents of the extracts. High-performance liquid chromatography and diode-array detection (HPLC-DAD) was used to determine the phenolic profiles of the extracts. DPPH, ABTS, and FRAP assays were used to evaluate the free radical scavenging properties of the X. strumarium extracts. The broth dilution method was used for antimicrobial activity assessments, the MTT assay was …

Inhibitory Effects Of Carvacrol On Glucansucrase From Streptococcus Mutans And Salivaryα-Amylase: In Silico And In Vitro Studies, Samet Kocabay, M. Abdullah Alagöz, Bi̇rnur Akkaya

Turkish Journal of Biology

Background/aim: Streptococcus mutans produces glucansucrase, an enzyme that converts sucrose into lactic acid, which lowers the pH in the oral environment and leads to tooth enamel demineralization, a key factor in dental caries. Additionally, glucansucrase facilitates the formation of extracellular polysaccharides, which promote bacterial adhesion to tooth surfaces. This study investigates the inhibitory effects of carvacrol, a natural compound, on glucansucrase activity both in vitro and in silico. Materials and methods: Glucansucrase enzyme was purified from S. mutans. The inhibitory effects of carvacrol against glucansucrase enzyme were investigated both in vitro and in silico. Results: In the presence of 50 …

Phytochemical Profile And Nematicidal Potential Of Essential Oil From Algerian Wildoriganum Vulgare Subsp. Glandulosum Defs., Amina Mezerket, Juan Emilio Palomares Rius, Souad Bouasla, Henia Saib

Turkish Journal of Biology

Background/aim: The root gall nematode Meloidogyne incognita constitute the most damaging species that infects many crops inAlgeria. The intense use of harmful agricultural chemical products has incited research to develop alternative methods with natural andecological advantages like essential oils extracted from plants. The objective of this study was to evaluate the efficacy of Origanum vulgaresubsp. glandulosum Desf. (Lamiaceae) essential oil on the development of the root-knot nematode M. incognita in potted tomatoes.Materials and methods: In pot trials, we assess the activity of O. vulgare subsp. glandulosum essential oil at two concentrations of0.75 and 0.37 mg /L against M . incognita. …

The Therapeutic Potential Of Salvia Aegyptiaca Extracts In Ethanol-Induced Gastric Ulcer:Insights Into Macroscopic, Histopathological, And Biochemical Mechanisms, Walid Mamache, Smain Amira, Fatima Benchikh, Hassiba Benabdallah, Amor Bencheikh, Hind Amira, Roumaissa Ounis, Mohammed Abdallah Torki, Chahrazed Kaoudoune

Turkish Journal of Biology

Background/aim: This study explores the antiulcer activity of different doses of Salvia aegyptiaca (SAE) methanol (ME) and decoctedextracts (DE) on ethanol-induced gastric ulcers in rats.Materials and methods: Female Wistar rats weighing 180–200 g were divided into five groups: control, omeprazole (positive control),and extract-treated (100, 200, and 400 mg/kg). Ulcers were induced with absolute ethanol 30 min after treatment with the extracts.The experiment was followed by macroscopic and histopathological examination. In vitro tests were also conducted to assess lipidperoxidation, catalase activity, mucus content, glutathione, and protein levels.Results: The study found that 100% ethanol caused significant damage, including colour and mucus loss, …

Antilipase Activities Of Cultivated Peppermint And Rosemary Essential Oils:In Vitro And In Silico Studies, Khadidja Bengana, Talia Serseg, Khedidja Benarous, Ari̇f Mermer, Yakup Şi̇ri̇n, Alaeddine Kaouka

Turkish Journal of Biology

Background/aim: The growing interest in essential oils clearly indicates the power of nature and aligns with our increasing need to findtherapeutic solutions in the natural world. This study aimed to investigate the inhibitory effects of the essential oils of Mentha × piperitaand Salvia rosmarinus, harvested from the Laghouat region of Algeria, against Candida rugosa lipase (CRL) and pancreatic lipasethrough both in vitro and in silico studies.Materials and methods: Essential oils were extracted via hydrodistillation and analyzed using gas chromatography–mass spectrometryand spectrophotometry. Their antilipase activities were assessed using an inhibition assay, and molecular docking was performed withAutoDock Vina to explore interactions …

Evaluation Of Physical And Chemical Condition Of A Group Of Waterloggedarchaeological Woods From The Yenikapı 16 Shipwreck, Sedef Hetto, Namik Kiliç, Asli Gökçe Kiliç

Turkish Journal of Earth Sciences

This study examined the physical and chemical condition of waterlogged archaeological wood (WAW) samples from the Yenikapı 16 shipwreck of plane (Platanus L.), elm (Ulmus L.), pine (Pinus L.), and fir (Abies L.), representing species with different wood properties. The maximum water content (MWC) and basic density (BD) values of 74 WAW samples from the shipwreck were calculated, and 7 of 74 samples were selected for analysis using scanning electron microscopy (SEM), X-ray fluorescence (XRF), and Fourier transform infrared spectroscopy (FTIR). The availability of samples, appropriate size, the species of the wood, and the wood’s degradation were all considered. The …

Environmental And Cultural Impacts Of The 8.2 Ka Event In Yenikapı (İstanbul/Türkiye), Ayşi̇n Konak, M. Namik Yalçin

Turkish Journal of Earth Sciences

The Neolithic lifestyle, which began in the 12th millennium BP with the emergence of villages in the core region extendingfrom Iran to central and southeastern Anatolia and Syria, began to spread to neighboring geographies, such as the Marmara region,in the 9th millennium BP. During the 8.2 ka event that occurred between 8300 and 7900 BP, cold and dry conditions prevailed in thenorthern hemisphere. During the winter months, the humidity decreased and cooling of about 6 ± 2 °C was observed. In order totest whether the 8.2 ka event was also effective in the İstanbul region, a set of inorganic geochemical …

Minero-Petrographic, Geochemical, And Multiisotopic Characterization Of The Ancientbanded Travertine Quarries Of The Lycus Valley (Denizli, Türkiye), Tamer Koralay, Nergi̇s İmre

Turkish Journal of Earth Sciences

The Lycus Valley in Western Anatolia has been the site of numerous civilizations since ancient times due to historical, geopolitical, and climatological characteristics. Banded travertine is a ubiquitous architectural stone observed in ancient settlements in the Lycus Valley. Banded travertines referred to as “Alabastro Fiorito,” “Alabastro Listato,” and “Alabastro Rossa” in archaeological bibliographies have been extracted from the ancient quarries of Çukurbağ, Hierapolis, Develi-Akköy, Gölemezli, and Tripolis in the Lycus Valley and are characterized by white, yellow, brown, red, and red-burgundy colored bands with thicknesses ranging from a few millimeters to centimeters. The banded travertines have similar mineral compositions and …

Characterization Of Stone Materials From The Roman Caracalla Bath In Ancyra, Zeynep Tanriverdi̇, Ali̇ Akin Akyol, Yusuf Kağan Kadioğlu

Turkish Journal of Earth Sciences

The Roman Caracalla Bath was built during the reign of Roman Emperor Caracalla (circa AD 200). Today it exists only inthe form of wall remnants at the foundation level and functions as an open-air museum. It is located on a mound approximately 2.5-mhigh along Ulus’s Çankırı Street in Ankara. This research paper aims to identify the characterization and implications for provenance ofthe stone materials used in the construction of the bath by using mineralogical, petrographic, and geochemical definitions. The resultsobtained from the stone materials also provide guidance for restoration and reinforcement of the bath. In this study, the 13 stone …

Paradigm Shift In Obesity Treatment: An Extensive Review Of Current Pipeline Agents, Ecesu Çeti̇n, Brian Pedersen, Mehmet Furkan Burak

Turkish Journal of Medical Sciences

Obesity is a multifaceted disease that poses a significant public health challenge. Recent discoveries in understanding the biological pathways that regulate satiety and metabolism have led to a shift in the treatment paradigm for obesity. Thus, the gap between pharmacological and surgical interventions has diminished. The latest approved anti-obesity medications are achieving weight loss comparable to surgery. These GLP-1 analog-based therapies not only cause substantial weight loss but also improve obesity-associated comorbidities. However, there are still unmet needs in obesity care, and treatment options with alternative pathways are necessary. Whether achieved through lifestyle changes or medication, weight loss often leads …

Synthetic Osteobiologics In Spine Surgery: A Review, Aydin Si̇nan Apaydin, Eli Johnson, Prince Antwi, Brett Rocos, Michael M. Haglund, Christopher Shaffrey, Peter Passias, Muhammad Adb-El-Barr, Khoi Than

Turkish Journal of Medical Sciences

Background/aimOsteobiologics are increasingly used in orthopedics and spine surgery to facilitate bone healing and prevent non-union. Synthetic osteobiologics are artificial materials crafted in laboratories that aim to replicate the natural composition and functionality of bone. Notable examples, such as calcium phosphate and calcium sulfate, are engineered to mirror the mineral aspect of bone. They mimic human bone functionality, exhibiting osteoconductive, osteoinductive, and osteogenic properties. These characteristics promote cell attachment, migration, recruitment, and differentiation. Consequently, synthetic osteobiologics (osteoconductive grafts) have been introduced in bone fracture repair. The main strength of synthetic osteobiologics in spine surgery lies in improving fusion rates and …

Genetic Mutations And Prognostic Indicators In Differentiated Thyroid Cancer: A Molecular Perspective, Hali̇m Özçevi̇k, Müge Öner Tamam, Gündüzalp Buğrahan Babacan, Selma Şengi̇z Erhan, Merve Nur Acar Tayyar, Bi̇ray Ertürk

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the relationship between the presence of BRAF, HRAS, NRAS, and KRAS gene mutations and the development of dedifferentiation (iodine-refractory disease) and extrathyroidal disease in patients with differentiated thyroid carcinoma (DTC).Materials and methods: Seventy-seven adult patients classified as intermediate and high-risk according to the ATA 2015 guidelines, who underwent total thyroidectomy followed by radioiodine I-131(RAI) therapy between June 2014 and December 2022, were included. Clinical data were collected via the hospital information system, including the number of surgeries, RAI treatments, and levels of thyroglobulin(Tg), anti-thyroglobulin, and thyroid-stimulating hormone. Histopathological subtypes of DTC were re-evaluated, and …

Impact Of Concurrent Parathyroid Adenoma On The Recurrence Of Differentiated Thyroid Carcinoma: A Retrospective Study, Derya Çayir, Alev Çinar, Mehmet Bozkurt, Bahadir Külah

Turkish Journal of Medical Sciences

Background/aim: The impact of concurrent parathyroid adenoma in differentiated thyroid carcinoma remains unclear. This study was performed to compare the recurrence rates of patients operated on for differentiated thyroid carcinoma with concomitant parathyroid adenoma and those operated on for thyroid carcinoma without detected parathyroid adenoma.Materials and methods: This retrospective study examined 340 patients who underwent total thyroidectomy for thyroid carcinoma at our institution. We compared the patients with concurrent parathyroid adenoma to those without, assessing clinical, laboratory, surgical, and histopathological findings and thyroid carcinoma recurrence over a 6-year postoperative period.Results: Among all patients, 53/340 (16%) were identified with parathyroid adenoma, …

Evaluation Of Nonmotor Symptoms In Myasthenia Gravis Patients, Aysel Tekeşi̇n, Çağla Şi̇şman, Ufuk Emre Toprak, Alena Sar, Burcu Akalin, Goncagül Koşargeli̇r, Meli̇h Tütüncü, Enes Yi̇ği̇t

Turkish Journal of Medical Sciences

Background/aim: Myasthenia gravis (MG) is chronic autoimmune disorder characterized primarily by muscle weakness and fatigue, due to autoantibodies targeting acetylcholine receptor at neuromuscular junction. In this study, we aimed to evaluate non-motor symptoms in myasthenia gravis patients and compare them with disease duration, severity and clinical features.Materials and methods: This prospective study was conducted with thirty-five myasthenia gravis patients and thirty-five healthy volunteers. Total of 35 patients, 17 women and 18 men with mean age of 52.9±13.6 years constituted patient group. Control group consisted of total of 35 participants, 23 women and 12 men with mean age of 46.9±12.2 years. …

Integrated Convolutional Neural Network For Skin Cancer Classification With Hair And Noise Restoration, Ni̇dhi̇ Bansal, Sri̇dhar Sundaramurthy

Turkish Journal of Medical Sciences

Background/aim: Skin lesions are commonly diagnosed and classified using dermoscopic images. There are many artifacts visible in dermoscopic images, including hair strands, noise, bubbles, blood vessels, poor illumination, and moles. These artifacts can obscure crucial information about lesions, which limits the ability to diagnose lesions automatically. This study investigated how hair and noise artifacts in lesion images affect classifier performance and how they can be removed to improve diagnostic accuracy.Materials and methods: A synthetic dataset created using hair simulation and noise simulation was used in conjunction with the HAM10000 benchmark dataset. Moreover, integrated convolutional neural networks (CNNs) were proposed for …

Relationship Between Bleeding Risk And Arterial Stiffness In Patients With Cerebral Aneurysms, Mehmet Seli̇m Gel, Hasan Çağri Postuk, İskender Samet Daltaban, Savaş Özer, Ercan Aydin, Emrah Keski̇n

Turkish Journal of Medical Sciences

Background/aimA risk factor assessment evaluating the susceptibility of cerebral aneurysms (CA) to rupture has not yet been established. Therefore, the clinical management of unruptured CA remains uncertain. Our aim was to assess whether arterial stiffness is associated with the development of rupture in patients with cerebral aneurysms.Materials and methodsAfter magnetic resonance angiography, 49 patients with cerebral aneurysm and subarachnoid haemorrhage and ruptured cerebral aneurysm detected by digital substraction angiography were included in the study. Arterial stiffness was measured using the VaSera VS-1000 vascular scanning system, expressed as cardio-ankle brachial index (CAVI). CAVI values were compared between patient groups.ResultsThe mean age …

Relationship Between The Density Of Degenerated Neurons In The Carotid Body And Changes In Blood Ph, Hakan Kina, Aydin Si̇nan Apaydin

Turkish Journal of Medical Sciences

Background/aimCarotid artery is the majority artery for brain feeding. Carotid Bodies (CBs) are located in carotid bifurcation and regulate body fluid pH. We aimed to evaluate the changes in CB-related pH levels as a consequence of degeneration induced by the ligation of both Common Carotid Arteries (BCCAL).Materials and methodsWe included 23 adult male New Zealand rabbits. A control group (n= 5); a sham group (0.5 mL saline injected n=5) and the main study group (subjected to the BCCAL procedure, n = 13). We monitored and recorded pH levels, and cardiac rhythms before, during, and after the experiments at two-day intervals. …

Relationship Between Hand Osteoarthritis Severity And Serum Resistin Levels In Women With Metabolic Syndrome: A Case-Control Study, Eki̇n Başak Doğanci, Berna İmge Aydoğan, Ni̇lgün Başkal, Safi̇ye Tuncer

Turkish Journal of Medical Sciences

Background/aimWe aimed to determine the relationship between clinical and radiological severity of hand osteoarthritis and serum resistin levels in women diagnosed with metabolic syndrome.Materials and methodsThe study was designed as a case-control study. A total of 87 women aged 50-65 years were evaluated; 29 patients diagnosed with metabolic syndrome and hand osteoarthritis (MetS (+), hand OA (+); Group 1), 29 patients without metabolic syndrome but with hand osteoarthritis (MetS (-), hand OA (+); Group 2) and 29 healthy controls (MetS (-), hand OA (-); Group 3). The diagnostic criteria of American College of Rheumatology (ACR) for hand osteoarthritis and National …

In Vitro Anticancer, Antioxidant And Chelating Activities Of Natural Organosulfur Compounds Originated From Türkiye: An Investigation On Breast And Colorectal Cancer Cells, Ümmügülsüm Polat Korkunç, Hi̇lal Çalik, Leyla Polat Köse, Rabi̇a Çakir Koç, Emi̇ne Karakuş

Turkish Journal of Medical Sciences

Background/aim:Taşköprü garlic, cultivated in the Taşköprü region of Kastamonu province, is a very famous in Türkiye.This study aimed to determine the anticancer and antioxidant effects of extracts from Kastamonu Taşköprü garlic on human breast cancer and colorectal cancer cells.Materials and methods:Taşköprü garlic, which contains natural organosulfur compounds, has a geographical registration. Taşköprü garlic, which contains natural organosulfur compounds (OSCs), has a geographical registration.Garlic contains oil- and water-soluble OSCs known to exhibit anticancer activity by interfering with MCF-7 and Caco-2 proliferation and tumor metastasis. In this study, the antiproliferative activity of oil- and water-soluble garlic extracts with and without glutathione at …

Are Cinnamon Derivatives Effective And Safe For Diabetes?, Methi̇ye Mancak, Ufuk Koca Çalişkan

Turkish Journal of Medical Sciences

Background/aimCinnamon spice is obtained by drying the tree bark of the Cinnamomum Schaeff genus. Cinnamomum genus belongs to the Lauraceae family and there are approximately 250 different species around the world. The most common species in the market are Cinnamomum verum J. S. Presl, C. cassia (L.) J. Presl, C. burmannii (Nees & T. Nees) Blume and C. loureiroi Nees. Cinnamon and its by-products are used for many years for their antidiabetic effect. In this research, the major chemical content and in vitro antidiabetic activities of different commercially available cinnamon samples were evaluated to conclude whether they are safe to …

Association Of Certain Biochemical Parameters Related To Bone Cycle With Genotype In Mps Iii-B Patients, Seda Gökkurt, İrem Peker Eyüboğlu, Banu Nur Güzel, Ercan Mihçi, Ayşe Özer, Mustafa Akki̇pri̇k

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to investigate the genotype-phenotype correlation in Sanfilippo type B patients in terms of bone formation/resorption parameters, and to determine the release/inhibition of biomarkers accompanying osteoporosis.Materials and Methods: Plasma levels of Osteoprotegerin, Matrix metalloproteinases (MMP2, MMP9), TIMP-1, TIMP-2, BALP, Cathepsin K, and TRACP-5b were examined by ELISA method in MPS IIIB patients. At the same time, mutations in the NAGLU gene causing this disease were detected by whole exome sequencing, and their correlation with biochemical parameters was investigated.Results: Based on the enzyme analysis results, MMP-9, TIMP1, TIMP-2, and MMP-2 were significantly high, while Cathepsin-K …

Ascorbic Acid Exhibits More Of A Protective Effect Than Estradiol Against Nephrotoxicity Induced By Malathion In Rats: A Histopathological And Molecular Docking Study, Mohammad Alhilal, Mahmoud Salem, Ahmed Albakoush, Suzan Alhilal, Basant Farag, Sobhi M. Gomha

Turkish Journal of Medical Sciences

Background/Aim: Despite the known harmful effects associated with malathion toxicity in various organs, it continues to be widely used for plant protection and insect control. This study is the first to compare the protective effects of estradiol and ascorbic acid against malathion-induced nephrotoxicity through histopathological assessment and molecular docking analyses.

Materials and Methods: This study was conducted using 20 female albino rats that were distributed into sham, malathion, malathion + estradiol, and malathion + ascorbic acid groups. Nephrotoxicity was induced by daily treatment with malathion, and the effects of estradiol and ascorbic acid on nephrotoxicity were evaluated. After 4 weeks …