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Artificial Intelligence In Medical And Biological Research: Promise And Perils Of Chatgpt And Deepseek In Advancing Healthcare, Mahmut Enes Kayaalp, Onur Gülteki̇n, Serhat Akçaalan, Hami̇t Çağlayan Kahraman, Hüseyi̇n Nevzat Topçu, Gülşah Kavrul Kayaalp
Artificial Intelligence In Medical And Biological Research: Promise And Perils Of Chatgpt And Deepseek In Advancing Healthcare, Mahmut Enes Kayaalp, Onur Gülteki̇n, Serhat Akçaalan, Hami̇t Çağlayan Kahraman, Hüseyi̇n Nevzat Topçu, Gülşah Kavrul Kayaalp
Turkish Journal of Biology
Background/aim: Artificial intelligence (AI), particularly large language models (LLMs) such as ChatGPT and DeepSeek, is being increasingly applied in clinical care, research, and education. The aim of this review is to examine how these tools may transform the conduct of medical and biological research and to define their limitations.
Materials and methods: A narrative synthesis of the literature was performed, encompassing studies published between 2020 and 2025. Peer-reviewed journals, systematic reviews, and high-impact original research articles were included to ensure an evidence-based overview. The principle applications, validation metrics, and clinical implications across orthopedics, oncology, cardiology, internal medicine, and the biological …
A Systematic Review Of Machine Learning In Heart Disease Prediction, Tathagat Banerjee, İshak Paçal
A Systematic Review Of Machine Learning In Heart Disease Prediction, Tathagat Banerjee, İshak Paçal
Turkish Journal of Biology
Background/aim: Cardiovascular diseases (CVDs) are a leading cause of global mortality, prompting the need for advanced predictive tools. While machine learning (ML) offers a powerful solution, there are significant challenges to clinical translation. This systematic review synthesizes the current state of ML in heart disease prediction, evaluating algorithmic performance, data utilization, and key translational challenges.
Materials and methods: Following PRISMA guidelines, a systematic search of literature published up to 2025 was conducted. From an initial pool of over 2500 records, a rigorous screening process yielded 65 studies for in-depth qualitative synthesis.
Results: Analysis showed that ensemble learning models dominate prediction …
Flavonoids And Phenolic Compounds: A Promising Avenue For Neurodegenerative Disease Therapy, Tesli̇me Özge Şahi̇n, Özge Cemali̇, Merve Özdemi̇r, Şeri̇fe Ayten, Duygu Ağagündüz
Flavonoids And Phenolic Compounds: A Promising Avenue For Neurodegenerative Disease Therapy, Tesli̇me Özge Şahi̇n, Özge Cemali̇, Merve Özdemi̇r, Şeri̇fe Ayten, Duygu Ağagündüz
Turkish Journal of Biology
Background/aim: Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and ALS are characterized by a progressive loss of nerve cells, for which no definitive cure currently exists. These conditions share common pathological mechanisms, including chronic neuroinflammation, oxidative stress, protein aggregation, and mitochondrial dysfunction. Flavonoids and other plant-derived phenolic compounds have recently attracted attention for the treatment of such conditions due to their antiinflammatory and antioxidant properties. This review explores the neuroprotective mechanisms of flavonoids and evaluates their potential for the prevention and treatment of neurodegenerative diseases.
Materials and methods: A literature search of the Web of Science, PubMed, and ScienceDirect databases …
Hsa_Circ_0001776 Regulates The Progression Of Acute Myeloid Leukemia Through The Mir-1269b/Pten Axis, Yaoyao Wang, Xiancong Yang, Simin Rong, Xiaoxu Lan, Chenhui Ti, Weimiao Sun, Baohui Yin, Youjie Li, Yunxiao Sun
Hsa_Circ_0001776 Regulates The Progression Of Acute Myeloid Leukemia Through The Mir-1269b/Pten Axis, Yaoyao Wang, Xiancong Yang, Simin Rong, Xiaoxu Lan, Chenhui Ti, Weimiao Sun, Baohui Yin, Youjie Li, Yunxiao Sun
Turkish Journal of Biology
Background/aim: Acute myeloid leukemia (AML) is a malignant neoplasm arising from bone marrow hematopoietic stem cells. It is a common subtype of childhood leukemia and remains challenging to cure. Emerging evidence suggests that circular RNAs (circRNAs), a class of noncoding RNAs, play key regulatory roles in tumor biology. Among their various functions, circRNAs often act as ‘sponges’ for microRNAs (miRNAs), modulating gene expression posttranscriptionally. This study investigates the functional role and clinical relevance of hsa_circ_0001776 in AML.
Materials and methods: Three AML cell lines and 22 peripheral blood samples were analyzed. Differential expression analysis of circRNAs in a GSE dataset …
Royal Jelly With Ellagic Acid Inhibits The Glycolytic Pathway And Induces Apoptosis Through Multiple Pathways In Colorectal Cancer, Tuğba Kul Köprülü
Royal Jelly With Ellagic Acid Inhibits The Glycolytic Pathway And Induces Apoptosis Through Multiple Pathways In Colorectal Cancer, Tuğba Kul Köprülü
Turkish Journal of Biology
Background/aim: Developing novel chemotherapeutics with high anticancer efficacy and low toxicity remains a critical challenge in oncology. Natural products have shown promise due to their multitargeted activity and favorable safety profiles. The present study investigates the combined anticancer effects of royal jelly (RJ) and ellagic acid (EA), two potent antioxidants of animal and plant origin.
Materials and methods: Royal jelly (RJ) and ellagic acid (EA) were applied to HT29 (ATCC HTB-38, Human colorectal adenocarcinoma), HCT116 (ATCC CCL-247, Human colorectal carcinoma) and BEAS-2B (ATCC CRL-3588, human bronchial epithelium) cell lines, and their antiproliferative effects were evaluated using a xCELLigence Real-Time Cell …
Differential Modulation Of Cisplatin Efficacy By Montelukast Sodium And Desloratadine In Lung Cancer, Seha Akduman, Büşra Yüksel, Di̇dem Teci̇mel, Ömer Faruk Bayrak, Di̇dem Seven, Fi̇kretti̇n Şahi̇n
Differential Modulation Of Cisplatin Efficacy By Montelukast Sodium And Desloratadine In Lung Cancer, Seha Akduman, Büşra Yüksel, Di̇dem Teci̇mel, Ömer Faruk Bayrak, Di̇dem Seven, Fi̇kretti̇n Şahi̇n
Turkish Journal of Biology
Background/aim: Despite advances in treatment, achieving effective and durable responses with chemotherapy remains a significant challenge in lung cancer management. This study investigates the effects of montelukast sodium (MLS) and desloratadine (DES), alone and in combination with cisplatin (CIS), on cell viability, apoptosis, cell cycle distribution, and antioxidant gene expression in A549 and DMS114 lung cancer cell lines.
Materials and methods: Cells were treated with CIS, MLS, DES, and their combinations for 24–72 h. Cell viability was assessed via MTS assay; apoptosis and cell cycle progression were analyzed by flow cytometry. The expression of antioxidant-related genes (GPX4, GSR, GCLC) was …
Evaluating Sh-Sy5y Cells As A Dopaminergic Neuronal Model: Morphological, Transcriptomic, And Proteomic Insights, Eylül Ece İşlek Camadan, Mehmet Sarihan, Murat Kasap, Gürler Akpinar, Eli̇fcan Koçyi̇ği̇t
Evaluating Sh-Sy5y Cells As A Dopaminergic Neuronal Model: Morphological, Transcriptomic, And Proteomic Insights, Eylül Ece İşlek Camadan, Mehmet Sarihan, Murat Kasap, Gürler Akpinar, Eli̇fcan Koçyi̇ği̇t
Turkish Journal of Biology
Background/aim: The SH-SY5Y neuroblastoma cell line is a popular in vitro model for neurodegenerative disease research, especially Parkinson’s disease (PD) research, but its use is complicated by limitations like the persistence of neuroblastoma-like features, unstable differentiation, mitochondrial dysfunction, and cellular stress. To address these limitations, this study tested a blended, nine-day differentiation protocol that sequentially applied all-trans retinoic acid (RA), brain-derived neurotrophic factor (BDNF), and dibutyryl cyclic adenosine monophosphate (dbcAMP). By evaluating key neuronal, dopaminergic, and PD-related markers, the research aims to determine if these differentiated SH-SY5Y cells are a suitable model for studying PD.
Materials and methods: A blended …
The Effects Of The Combined Use Of Carbon Quantum Dots And Antibacterial Agents On Pathogenic Bacteria, Derya Doğanay, İbrahi̇m Serkan Avşar, Şevval Maral Özcan Aykol, Gamze Çamlik, Besa Bi̇lakaya, İsmai̇l Tuncer Deği̇m
The Effects Of The Combined Use Of Carbon Quantum Dots And Antibacterial Agents On Pathogenic Bacteria, Derya Doğanay, İbrahi̇m Serkan Avşar, Şevval Maral Özcan Aykol, Gamze Çamlik, Besa Bi̇lakaya, İsmai̇l Tuncer Deği̇m
Turkish Journal of Biology
Background/aim: This study evaluates the challenges associated with overcoming antimicrobial resistance and innovative approaches to combat multidrug-resistant (MDR) bacterial infections.
Materials and methods: Novel codoped carbon quantum dots (CCQDs) were synthesized using citric acid as the carbon source and L-cysteine as the nitrogen codoping atom. The formulation in which citric acid was retained was designated as CCQDs-1, whereas the purified version, from which citric acid was removed, was termed CCQDs-2. The antibacterial properties of CCQDs-1 and CCQDs-2 were compared using the agar well diffusion method. This study comprehensively characterizes these nanomaterials and evaluates their antibacterial potential, both alone and in …
Unraveling The Genetic Architecture Of Rice Yield Potential By Investigating The Impacts Of Heterosis And Inbreeding Depression, Shahwar Fatima, Muhammad Rashid, Dalal Sulaiman Alshaya, Adeel Khan, Areeqa Shamshad, Zia-Ul Qamar, Asim Abbasi, Kotb Attia, Sajid Fiaz, Qamar Uz Zaman
Unraveling The Genetic Architecture Of Rice Yield Potential By Investigating The Impacts Of Heterosis And Inbreeding Depression, Shahwar Fatima, Muhammad Rashid, Dalal Sulaiman Alshaya, Adeel Khan, Areeqa Shamshad, Zia-Ul Qamar, Asim Abbasi, Kotb Attia, Sajid Fiaz, Qamar Uz Zaman
Turkish Journal of Agriculture and Forestry
Understanding the inheritance pattern, heterotic groups, and inbreeding depression is a prerequisite for hybrid rice seed production. Therefore, this study employed a full diallel mating system involving two tall varieties and three medium-statured mutants. The results revealed the significant differences in plant height, panicle length, tillers per plant, fertility percentage and grain yield. Heterosis was more pronounced for grain yield (24.2%), followed by tillers per plant (19.8%), and panicle length (19.2%). Conversely, inbreeding depression was lowest for tillers per plant (–11.5%) and grain yield (–6.8%). The additive–dominance model provided a good fit for tillers per plant and plant height, indicating …
Effect Of Three Different Crop Rotations On Seed Productivity And Soil Properties In Organic Tomato Seed Production: A Comprehensive 13-Year Field Study With Three Cycles, Gülay Beşi̇rli̇, İbrahi̇m Sönmez, Bariş Albayrak, Mehmet Şi̇mşek, Zühtü Polat, Nesri̇n Uzunoğullari, Nesri̇n Tunali̇, Gürsel Çeti̇n, Razi̇ye Kul
Effect Of Three Different Crop Rotations On Seed Productivity And Soil Properties In Organic Tomato Seed Production: A Comprehensive 13-Year Field Study With Three Cycles, Gülay Beşi̇rli̇, İbrahi̇m Sönmez, Bariş Albayrak, Mehmet Şi̇mşek, Zühtü Polat, Nesri̇n Uzunoğullari, Nesri̇n Tunali̇, Gürsel Çeti̇n, Razi̇ye Kul
Turkish Journal of Agriculture and Forestry
This study was carried out to investigate the effects of three different crop rotation practices and three cycle periods on tomato seed yield and quality and some soil characteristics in organic farming conditions. The crop rotations included tomato as the primary crop along two intercrops (CR-1: tomato-leek-okra crop rotation, CR-2: tomato-head cabbage-lettuce crop rotation, CR-3: tomato-watermelon-onion crop rotation). At the end of the study, seed yield and quality of other vegetable species (leek, okra, head cabbage, lettuce, watermelon, and onion) included in the trial along with tomato, seed-borne pathogens, and some soil properties of the trial area were determined. The …
The Impact Of Endogenous And Exogenous Fungi In Saline-Alkali Soil On The Growth And Root System Of Pine Trees, Chunfeng Shi, Zhixin Ju, Kan Gao, Wenzhong Fan, Bo Yang
The Impact Of Endogenous And Exogenous Fungi In Saline-Alkali Soil On The Growth And Root System Of Pine Trees, Chunfeng Shi, Zhixin Ju, Kan Gao, Wenzhong Fan, Bo Yang
Turkish Journal of Agriculture and Forestry
The objective is to explore planting methods that enhance the ability of black pine to cope with salt stress environments, improve its growth under such conditions, and observe its growth and physiological characteristics under various experimental conditions. For this purpose, endophytic mycorrhizal Indian pear-shaped fungus and ectomycorrhizal two-colored wax mushrooms were selected and inoculated onto potted black pine seedlings, and a control group was set up. After inoculation, the mycorrhizal infection rate, salt damage symptoms, growth rate, root parameters, and various physiological indicators under different salt stress durations were evaluated. Results showed that as the salt concentration was raised to …
Adapting Northern Herbs For Desertification Control Around Poyang Lake, China, Haijing Xiao, Zhenwu Bian, Junyu Xu, Shimeng Li, Mengting Xiao, Min Guo, Xianglong Bu, Muhammad Rafiq, Chunsong Cheng
Adapting Northern Herbs For Desertification Control Around Poyang Lake, China, Haijing Xiao, Zhenwu Bian, Junyu Xu, Shimeng Li, Mengting Xiao, Min Guo, Xianglong Bu, Muhammad Rafiq, Chunsong Cheng
Turkish Journal of Agriculture and Forestry
Desertification poses a pressing global challenge, threatening both environmental stability and socioeconomic well-being, and it requires detailed monitoring of its dynamics and drivers to inform land restoration and sustainable development strategies. Around Poyang Lake, China’s largest freshwater lake, desertification has triggered profound ecological degradation and economic losses, intensified by human activities and climate change. This study investigates these challenges by evaluating an integrated revegetation approach that combines Beach vitex (V. rotundifolia) with nitrogen-fixing licorice (Glycyrrhiza spp.) to improve soil quality, stabilize environmental conditions, and foster sustainable land management. Field experiments examined the drought tolerance and soil enhancement capabilities of five …
Changes In Phenolics And Organic Acid Contents Of Postharvest Eggplants In Response To Preharvest Fertilizer Applications And Postharvest Edible Coatings, Nuretti̇n Yilmaz, Şeyda Çavuşoğlu
Changes In Phenolics And Organic Acid Contents Of Postharvest Eggplants In Response To Preharvest Fertilizer Applications And Postharvest Edible Coatings, Nuretti̇n Yilmaz, Şeyda Çavuşoğlu
Turkish Journal of Agriculture and Forestry
Pre- and postharvest techniques play a key role in improving the quality and shelf life of fresh horticultural products. The aim of this 2-year study was to evaluate the postharvest phenolic and organic acid content in eggplants under different fertilizers and postharvest treatments. Before planting, all plots were treated with 2000 cc da−1 of humic acid through a drip irrigation system. Plots treated only with humic acid were considered the control group. Fifteen days after planting, the other plots were treated with 2000 cc da−1 of liquid vermicompost fertilizer or 2000 cc da−1 of organomineral fertilizer via drip irrigation. Postharvest, …
Salinity Response In Tunisian Durum Wheat Genotypes: Genetic Relationships, Phenotypic Variation, And Ssr Marker-Based Computational Modelling, Rim Mzid, Rayda Ben Ayed, Imène Ayachi, Elyès Babay, İnci̇ Tolay, Lamia Hamrouni, Abdullah Eren, Mohsen Hanana
Salinity Response In Tunisian Durum Wheat Genotypes: Genetic Relationships, Phenotypic Variation, And Ssr Marker-Based Computational Modelling, Rim Mzid, Rayda Ben Ayed, Imène Ayachi, Elyès Babay, İnci̇ Tolay, Lamia Hamrouni, Abdullah Eren, Mohsen Hanana
Turkish Journal of Agriculture and Forestry
This study identifies salt-tolerant durum wheat genotypes for breeding programmes by integrating phenotypic, genotypic, and computational analyses of 27 Mediterranean varieties. Cluster analysis and principal coordinate analysis (PCoA) revealed two distinct genetic groups: modern genotypes (high-yielding Tunisian/Italian cultivars) and ancient genotypes (traditional Tunisian landraces). Among tested cultivars, JnehKhottifa and Grécale exhibited exceptional salinity tolerance, maintaining >80% germination at 200 mM NaCl, while Om Rabiaa and Agili showed sensitivity (<50% germination). Bayesian network modelling was used to explore the probabilistic relationships between simple sequence repeat (SSR) markers (e.g., CFD40 and GWM182, PIC = 0.561) and important traits such as root length and germination rate under stress. Genetic diversity analysis (average PIC = 0.407) highlighted the potential of SSR markers for trait-marker associations. These findings establish a valuable platform for enhancing marker-assisted selection salt- tolerant durum wheat varieties, essential for securing yields in saline-prone Mediterranean regions.
Unraveling The Morphophysiological, Biochemical, And Yield Responses Of Maize Genotypes To Contrasting Nitrogen Conditions Using Multivariate Approaches, Muhammad Faheem Jan, Yu Lin, Waqas Liaqat, Muhammad Tanveer Altaf, Changzhuang Liu, Wang Shuai, Gönül Cömertpay, Israr Aziz, Önder Albayrak, Ming Li
Unraveling The Morphophysiological, Biochemical, And Yield Responses Of Maize Genotypes To Contrasting Nitrogen Conditions Using Multivariate Approaches, Muhammad Faheem Jan, Yu Lin, Waqas Liaqat, Muhammad Tanveer Altaf, Changzhuang Liu, Wang Shuai, Gönül Cömertpay, Israr Aziz, Önder Albayrak, Ming Li
Turkish Journal of Agriculture and Forestry
Genotypic variation plays a pivotal role in modulating the activity of nitrogen (N) assimilating enzymes, photosynthetic rate, N accumulation, plant growth, and yield. Despite this, the extent to which growth and N-assimilating enzymes exhibit differential responses across genotypes and their influence on yield and nitrogen use efficiency (NUE) remains inadequately explored. This study aimed to elucidate genetic variations among two inbred maize lines (Huang C and 178) and their hybrid (Huang C × 178) for key morphophysiological and biochemical traits under contrasting N conditions. Multivariate statistical methods, including principal component analysis (PCA) and structural equation modeling (SEM), were used to …
Exocysteine Application Mitigates Salt Stress In Chickpea (Cicer Arietinum L.), Ece Ni̇sa İmamoğlu, Murat Erdem Güzel, Asi̇m Kadioğlu, Aykut Sağlam
Exocysteine Application Mitigates Salt Stress In Chickpea (Cicer Arietinum L.), Ece Ni̇sa İmamoğlu, Murat Erdem Güzel, Asi̇m Kadioğlu, Aykut Sağlam
Turkish Journal of Agriculture and Forestry
Environmental factors such as salt stress inhibit the growth of plants and agricultural productivity. Exogenous amino acid application has been shown to benefit plants. However, the effect of cysteine application on salt stress reduction in chickpea (Cicer arietinum L.) is unknown. This study examined how exogenous cysteine could reduce salt stress in 2 chickpea cultivars with different salt tolerances. Salt-resistant Gökçe and salt-sensitive Küsmen cultivars were subjected to 100 mM NaCl stress with or without a 100 μM Cys pretreatment. Without Cys pretreatment, salt stress caused the sensitive Küsmen variety to lose 1.49 times its dry weight and 1.35 times …
Nitrogen Management In Enhancing Raspberry (Rubus Idaeus L.) Productivity And Sustainable Development In Fruit Cultivation, Aleksandar Leposavić, Žaklina Karaklajić-Stajić, Sezai̇ Erci̇şli̇, Darko Jevremović, Ivana S. Glišić, Branko Popović, Olga Mitrović
Nitrogen Management In Enhancing Raspberry (Rubus Idaeus L.) Productivity And Sustainable Development In Fruit Cultivation, Aleksandar Leposavić, Žaklina Karaklajić-Stajić, Sezai̇ Erci̇şli̇, Darko Jevremović, Ivana S. Glišić, Branko Popović, Olga Mitrović
Turkish Journal of Agriculture and Forestry
This study investigated the effect of reduced nitrogen (N) fertilizer dosage on the vegetative and generative potential, physical and chemical characteristics, and fruit yield of raspberry (Rubus idaeus L.). Two raspberry cultivars (Willamette and Meeker) were treated with low and high doses of calcium ammonium nitrate and urea over 3 consecutive years (2021–2023) in Western Serbia. Basic floricane traits and fruit quality parameters were analyzed using widely accepted methodologies. The results showed significant variations in primocane growth, floricane traits, and berry quality in response to different N fertilizer doses, whereas soluble solid content (SSC) was more stable. Lower N fertilizer …
Development Of Functional Cottage Cheese Enriched With Elderberry Pomace Powder: Nutritional And Antioxidant Enhancement, Roxana Nicoleta Ratu, Florina Stoica, Ioana Cristina Crivei, Ionut Dumitru Velescu, Florin Daniel Lipsa, Andreea Bianca Balint, Romina Alina Marc, Petru Marian Cârlescu, Marius Giorgi Usturoi, Emi̇ne Maci̇t
Development Of Functional Cottage Cheese Enriched With Elderberry Pomace Powder: Nutritional And Antioxidant Enhancement, Roxana Nicoleta Ratu, Florina Stoica, Ioana Cristina Crivei, Ionut Dumitru Velescu, Florin Daniel Lipsa, Andreea Bianca Balint, Romina Alina Marc, Petru Marian Cârlescu, Marius Giorgi Usturoi, Emi̇ne Maci̇t
Turkish Journal of Agriculture and Forestry
The increasing demand for sustainable and functional foods has driven interest in utilising agro-industrial by-products, such as elderberry pomace, to enhance the nutritional and antioxidant properties of food products. This study aimed to develop a functional cottage cheese enriched with elderberry pomace powder (EPP) and evaluate its nutritional composition, antioxidant potential, sensory acceptability, and textural properties. Cottage cheese samples were formulated with EPP at concentrations of 3% and 5%, alongside a control sample devoid of EPP. The results showed that the inclusion of EPP significantly increased the levels of anthocyanins, flavonoids, and polyphenols, along with enhanced antioxidant activity, compared to …
Study On The Flow Field Characteristics Of The Air-Suction Jujube Harvester Pipeline Based On Magnetohydrodynamic Airflow Control, Jing Nie, Qi Zhang, Jiashun Jiang, Jingbin Li, Longpeng Ding, Shufeng Li, Liming Xu, Mehmet Çeçen, Savaş Tanrisever
Study On The Flow Field Characteristics Of The Air-Suction Jujube Harvester Pipeline Based On Magnetohydrodynamic Airflow Control, Jing Nie, Qi Zhang, Jiashun Jiang, Jingbin Li, Longpeng Ding, Shufeng Li, Liming Xu, Mehmet Çeçen, Savaş Tanrisever
Turkish Journal of Agriculture and Forestry
This study aimed to address the issue of suction force attenuation in the air-suction jujube (red date) harvester due to pipeline pressure loss. The active flow control method based on magnetohydrodynamics was used to optimize the pipeline flow field and reduce pressure loss. Through multiphysics field coupling theory modeling and numerical simulation, the regulatory effects of different electromagnetic field parameters on the pipeline flow field were characterized. An experimental platform was established to verify that the optimized electrode tip density, electrode voltage, and magnetic induction intensity could significantly increase the outflow gas velocity, pressure difference, and harvesting efficiency of the …
Synthesis Of Vinyl Esters Of Aromatic Carboxylic Acids In The Presence Of Zn/Sioc, Zno/Sioc, And Ni/Sioc Catalytic Systems, Shavkat Tursunov, Askar Parmanov, Suvankul Nurmanov, Odiljon Ziyadullayev, Dilshod Boykobilov, Liudmila Khoroshko, Monika Wilamowska-Zawlocka, Balanand Santhosh, Olim Ruzimuradov
Synthesis Of Vinyl Esters Of Aromatic Carboxylic Acids In The Presence Of Zn/Sioc, Zno/Sioc, And Ni/Sioc Catalytic Systems, Shavkat Tursunov, Askar Parmanov, Suvankul Nurmanov, Odiljon Ziyadullayev, Dilshod Boykobilov, Liudmila Khoroshko, Monika Wilamowska-Zawlocka, Balanand Santhosh, Olim Ruzimuradov
Turkish Journal of Chemistry
In this work, various aromatic monocarboxylic and dicarboxylic acids were subjected for the first time to a vinylation reaction with acetylene under heterogeneous catalytic conditions using catalytic systems based on silicon oxycarbide supported on silicon carbide (SiC): zinc silicon oxycarbide (Zn/SiOC), zinc oxide silicon oxycarbide (ZnO/SiOC), and nickel silicon oxycarbide (Ni/SiOC). The influence of the nature of the starting materials, temperature, reaction duration, solvent, and catalyst type on the yield of vinyl esters was investigated. The vinylation reaction of aromatic carboxylic acids with acetylene was carried out at 1:2 molar ratio, using a Zn/SiOC-50 catalytic system at a loading of …
Levothyroxine Combined With Selenium Nanoparticles In One Liposomal Delivery System For Hypothyroidism, Eylül Atan, Güli̇z Ak
Levothyroxine Combined With Selenium Nanoparticles In One Liposomal Delivery System For Hypothyroidism, Eylül Atan, Güli̇z Ak
Turkish Journal of Chemistry
Levothyroxine, as a thyroid-stimulating hormone, is the primary drug used for hypothyroidism treatment, but it has poor bioavailability. Selenium (Se) plays an important role in regulating thyroid function; moreover, selenium nanoparticles (SeNPs) offer advantages over other Se forms. Liposomal delivery systems, especially those coated with polyethylene glycol (PEG), can increase the oral bioavailability of drugs and provide controlled release. In our research, as described in this paper, we aimed to develop an orally applicable liposomal delivery system to achieve enhanced treatment of hypothyroidism with SeNP characteristics, controlled levothyroxine release, and improved bioavailability of both drug and SeNPs. The SeNPs have …
Synthesis, Biological Evaluation, And Theoretical Studies Of 2-Amino-3-Cyano-4-(L-Phenylalaninyl)Quinolines: Anticancer Potential And Egfr Inhibition, İlbi̇lge Merve Şenol, Begüm Nurpeli̇n Sağlik Özkan, İlhami̇ Çeli̇k, Ahmet Çağri Karaburun
Synthesis, Biological Evaluation, And Theoretical Studies Of 2-Amino-3-Cyano-4-(L-Phenylalaninyl)Quinolines: Anticancer Potential And Egfr Inhibition, İlbi̇lge Merve Şenol, Begüm Nurpeli̇n Sağlik Özkan, İlhami̇ Çeli̇k, Ahmet Çağri Karaburun
Turkish Journal of Chemistry
Quinoline derivatives have garnered significant attention owing to their wide range of biological activities, particularly their anticancer potential. In this study, six novel 4-aminoquinoline derivatives incorporating a phenylalanine methyl ester moiety were synthesized and structurally characterized. The cytotoxic activities of the synthesized compounds were assessed against A549 and MCF-7 cancer cell lines, along with the noncancerous NIH3T3 fibroblast cell line. Compounds 4d and 4e displayed potent anticancer activity with low IC₅₀ values, while exhibiting negligible toxicity toward normal cells. Moreover, these compounds exhibited moderate inhibitory activity against EGFR. Molecular docking studies were conducted to elucidate the binding modes of compounds …
K-Carrageenan Fabricated Γ-Irradiated Graphene Oxide Hydrogel: A Versatile Anticancer Nanodrug Carrier System, Samina Sarwar, Sumayya Aziz, Asif Raza, Tariq Yasin, Nuzhat Shafi
K-Carrageenan Fabricated Γ-Irradiated Graphene Oxide Hydrogel: A Versatile Anticancer Nanodrug Carrier System, Samina Sarwar, Sumayya Aziz, Asif Raza, Tariq Yasin, Nuzhat Shafi
Turkish Journal of Chemistry
In this study, gamma-irradiated graphene oxide was incorporated into novel pH-responsive hydrogels. The biopolymer kappa carrageenan was blended with polyvinyl alcohol in a silane crosslinked biopolymer, and the effect of gamma irradiation dosage was studied. Nonhazardous tetraethoxysilane (TEOS) was used as a crosslinker. The hydrogels were characterized with chemical and thermal analysis, scanning electron microscopy, and structural analysis using a variety of analytical tools. The swelling behavior of fabricated hydrogels was assessed in various solution media. As the pH of the media increased, the swelling ratio of hydrogels decreased. All fabricated hydrogels had a high swelling ratio at acidic and …
Green Synthesis Of Silver Nanoparticles Using Sumac Fruit By Microwave And Traditional Methods: Characterization, Anticancer, And Antimicrobial Activities, Melek Hinis, Tuğçe Karaduman Yeşi̇ldal, Demet Erdönmez, Ayfer Menteş
Green Synthesis Of Silver Nanoparticles Using Sumac Fruit By Microwave And Traditional Methods: Characterization, Anticancer, And Antimicrobial Activities, Melek Hinis, Tuğçe Karaduman Yeşi̇ldal, Demet Erdönmez, Ayfer Menteş
Turkish Journal of Chemistry
Green synthesis of silver nanoparticles (Ag-NPs) was carried out with sumac fruit extract using a microwave-assisted (MWA) method and a traditional method (TDM). The properties of nanoparticles synthesized by both methods were characterized and compared.Although both methods are environmentally friendly, the MWA method was faster, more efficient, and economical. When creating Ag-NPs, variables like temperature, pH, reaction duration, extract concentration, and silver ion concentration were considered. The production of Ag-NPs was confirmed by ultraviolet–visible spectra that displayed the surface plasmon resonance band centered at 433 and 436 nm in the MWA and TDM techniques, respectively. The results of the scanning …
Design And Synthesis Of Folate Receptor-Targeted Squaraine Dye Complex For Photodynamic Therapy, Ömer Sonkaya
Design And Synthesis Of Folate Receptor-Targeted Squaraine Dye Complex For Photodynamic Therapy, Ömer Sonkaya
Turkish Journal of Chemistry
In recent years, new treatment methods have been developed in addition to traditional treatments to eliminate cancer, one of the deadliest diseases. Given the shortcomings of conventional therapies, including the emergence of drug resistance and selectivity to the target cell, a considerable number of researchers have directed their attention toward the investigation of alternative, less invasive strategies for the treatment of cancer. Photodynamic therapy (PDT) has received great attention in the scientific community as it is seen as a promising method of cancer treatment. Various approaches have been adopted to identify new and more effective photosensitizers (PSs) that reduce adverse …
Eco-Friendly Synthesis Of Carob- And Ginger-Modified Gold Nanoparticles For Enhanced Catalytic Applications, Muradi̇ye Şahi̇n, İlkay Hi̇lal Gübbük, Mustafa Ersöz
Eco-Friendly Synthesis Of Carob- And Ginger-Modified Gold Nanoparticles For Enhanced Catalytic Applications, Muradi̇ye Şahi̇n, İlkay Hi̇lal Gübbük, Mustafa Ersöz
Turkish Journal of Chemistry
This study aimed to investigate the catalytic performance of gold nanoparticles (AuNPs) obtained by using ginger and carob antioxidant plants as reducing and stabilizing agents. In the first stage of the study, AuNPs were successfully produced using these herbal extracts via a green synthesis method, without the need for toxic chemicals, in a sustainable, economical, rapid, energy-efficient, and easy way. In the second stage, the structural analysis and catalytic applications of the obtained AuNPs were investigated. Advanced techniques such as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), UV-Vis spectroscopy, and energy …
Design Of A Snp Panel For Highly Accurate Paternity Identification In Eşme Sheep, Onur Yilmaz, İbrahi̇m Cemal, Orhan Karaca, Cengi̇z Elmaci, Nezi̇h Ata
Design Of A Snp Panel For Highly Accurate Paternity Identification In Eşme Sheep, Onur Yilmaz, İbrahi̇m Cemal, Orhan Karaca, Cengi̇z Elmaci, Nezi̇h Ata
Turkish Journal of Veterinary & Animal Sciences
SNP paternity testing panels offer high-resolution capabilities for determining livestock paternity, thereby enhancing the reliability of genetic verification and ensuring pedigree record accuracy. In this study, we aimed to develop a SNP-based paternity test panel utilizing a 50K SNP chip for paternity testing and pedigree verification in the Eşme sheep breed. Additionally, the study sought to validate the paternity test panel. Based on data from 26 rams and 524 lambs of the Eşme sheep breed, the results indicated that the 50K SNP chip used demonstrated a very high genotyping rate, with the majority of its 53,738 SNPs exhibiting significant polymorphism. …