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Density Functional Theory-Supported Studies Of Structural And Electronic Properties Of Substituted-Phenol Derivatives Synthesized By Efficient O- Or C-Arylation Via Chan--Lam Or Suzuki Cross-Coupling Reactions, Hafiz Mansoor Ikram, Nasir Rasool, Muhammad Ali Hashmi, Muhammad Arfan Anjum, Kulsoom Ghulam Ali, Muhammad Zubair, Gulraiz Ahmad, Tariq Mahmood
Density Functional Theory-Supported Studies Of Structural And Electronic Properties Of Substituted-Phenol Derivatives Synthesized By Efficient O- Or C-Arylation Via Chan--Lam Or Suzuki Cross-Coupling Reactions, Hafiz Mansoor Ikram, Nasir Rasool, Muhammad Ali Hashmi, Muhammad Arfan Anjum, Kulsoom Ghulam Ali, Muhammad Zubair, Gulraiz Ahmad, Tariq Mahmood
Turkish Journal of Chemistry
The present study reports the efficient synthesis and computational studies of the structural and electronic properties of some interesting substituted phenol derivatives. Efficient and versatile procedures to synthesize a series of diaryl ether derivatives (2a-2c, 4a-4h) and bis-arylated products (5a-5c) are described. In this manuscript, using the commercially available starting material 1 and 3, a 1-step approach was developed by means of Cu(II)-mediated Chan-Lam and Pd-catalyzed Suzuki cross-coupling reactions to synthesize diaryl ether and bis-arylated products with moderate to good yields. The starting substrates, 2-bromo-4-methylphenol 1 or 2,4-dibromophenol 3, were both treated with several arylboronic acids, which led to the …
Characterisation Of Chitin In The Cuticle Of A Velvet Worm (Onychophora), Hartmut Greven, Murat Kaya, İdri̇s Sargin, Talat Baran, Reinhardt Møbjerg Kristensen, Martin Vinther Sorensen
Characterisation Of Chitin In The Cuticle Of A Velvet Worm (Onychophora), Hartmut Greven, Murat Kaya, İdri̇s Sargin, Talat Baran, Reinhardt Møbjerg Kristensen, Martin Vinther Sorensen
Turkish Journal of Zoology
We characterize the trunk cuticle of velvet worms of the Peripatoides novaezealandiae-group (Onychophora) using SEM, TEM, Fourier transform infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA). TEM and SEM revealed a relatively uniform organization of the delicate cuticle that is covered by numerous bristled and nonbristled papillae with ribbed scales arranged in transverse rows. The cuticle consists of a very thin multilayered epicuticle of varying appearance followed by the largely fibrous procuticle. The irregularly arranged nanofibres of isolated cuticular chitin seen by SEM are considered as bundles of chitin fibres. FT-IR and TGA showed that the chitin is of the α-type. …
Protective Effects Of Ghrelin On Kidney Tissue In Rats With Partial Ureteral Obstruction, Serhan Çi̇men, Cemal Taşdemi̇r, Ni̇gar Vardi, Burhan Ateş, Seda Taşdemi̇r, Ayla Özaydoğdu Çi̇men
Protective Effects Of Ghrelin On Kidney Tissue In Rats With Partial Ureteral Obstruction, Serhan Çi̇men, Cemal Taşdemi̇r, Ni̇gar Vardi, Burhan Ateş, Seda Taşdemi̇r, Ayla Özaydoğdu Çi̇men
Turkish Journal of Medical Sciences
Background/aim: The aim was to investigate the protective and therapeutic effects of ghrelin, which has antioxidant and antiinflammatory activity, on preventing kidney damage that occurs by induced partial ureteral obstruction in rats.Materials and methods: Twenty-eight adult male rats were included in the study, and the rats were divided into 4 groups. After the laparotomy operation on the sham group, the ureter was identified in the retroperitoneal area and was duly sutured (n = 7). Ghrelin was administered for seven days intraperitoneally, and after the nephrectomy performed on the 15th day, the rats were sacrificed (n = 7). A partial ureteral …
Three Dimensional Printing And Biomaterials In The Repairment Of Bone Defects; Hydroxyapatite Pla Filaments, İsmai̇l Kaya, Meryem Cansu Şahi̇n, İlker Deni̇z Ci̇ngöz, Nevi̇n Aydin, Murat Atar, Ceren Kizmazoğlu, Sali̇h Kavuncu, Hasan Emre Aydin
Three Dimensional Printing And Biomaterials In The Repairment Of Bone Defects; Hydroxyapatite Pla Filaments, İsmai̇l Kaya, Meryem Cansu Şahi̇n, İlker Deni̇z Ci̇ngöz, Nevi̇n Aydin, Murat Atar, Ceren Kizmazoğlu, Sali̇h Kavuncu, Hasan Emre Aydin
Turkish Journal of Medical Sciences
Background/aim: Application fields of bone tissue engineering studies continue to expand. New biocompatible materials aimed to improve bone repairment and regeneration of implants are being discovered everyday by scientists, engineers, and surgeons. Our objective in this study is to combine polylactic acid which is a polymer with hydroxyapatite in the repairment of bone defects considering the increased need by medical application fields. Materials and methods: After 750 g of PLA with a diameter of 2.85 mm was granulated into minimum particles, these particles were homogenously mixed with hydroxyapatite prepared in laboratory environment. Using this mixture, HA-PLA filament with a diameter …
Association Between Ppargc1a Single Nucleotide Polymorphisms And Increased Risk Of Nonalcoholic Fatty Liver Disease Among Iranian Patients With Type 2 Diabetes Mellitus, Leila Saremi, Shirin Lotfipanah, Masumeh Mohammadi, Hassan Hosseinzadeh, Zahra Hosseini-Khah, Behrooz Johari, Zohreh Saltanatpour
Association Between Ppargc1a Single Nucleotide Polymorphisms And Increased Risk Of Nonalcoholic Fatty Liver Disease Among Iranian Patients With Type 2 Diabetes Mellitus, Leila Saremi, Shirin Lotfipanah, Masumeh Mohammadi, Hassan Hosseinzadeh, Zahra Hosseini-Khah, Behrooz Johari, Zohreh Saltanatpour
Turkish Journal of Medical Sciences
Background/aim: Environmental and genetic factors may play a major role in the development of nonalcoholic fatty liver disease (NAFLD) among people with obesity and type 2 diabetes mellitus. Based on the fact that PGC-1?, as the protein encoded by the PPARGC1A gene, plays a key role in energy metabolism pathways, it has been hypothesized that polymorphisms within the PPARGC1Agene may be associated with increased risks of NAFLD. Thus, this study was designed to evaluate the Gly482Ser polymorphism (rs8192678) within the PPARGC1A gene and its association with the increased risk of NAFLD in Iranian patients with type 2 diabetes.Materials and methods: …
Community Detection In Complex Networks Using A New Agglomerative Approach, Majid Arasteh, Somayeh Alizadeh
Community Detection In Complex Networks Using A New Agglomerative Approach, Majid Arasteh, Somayeh Alizadeh
Turkish Journal of Electrical Engineering and Computer Sciences
Complex networks are used for the representation of complex systems such as social networks. Graph analysis comprises various tools such as community detection algorithms to uncover hidden data. Community detection aims to detect similar subgroups of networks that have tight interconnections with each other while, there is a sparse connection among different subgroups. In this paper, a greedy and agglomerative approach is proposed to detect communities. The proposed method is fast and often detects high-quality communities. The suggested method has several steps. In the first step, each node is assigned to a separated community. In the second step, a vertex …
Speech Emotion Recognition Using Semi-Nmf Feature Optimization, Surekha Reddy Bandela, T Kishore Kumar
Speech Emotion Recognition Using Semi-Nmf Feature Optimization, Surekha Reddy Bandela, T Kishore Kumar
Turkish Journal of Electrical Engineering and Computer Sciences
In recent times, much research is progressing forward in the field of speech emotion recognition (SER). Many SER systems have been developed by combining different speech features to improve their performances. As a result, the complexity of the classifier increases to train this huge feature set. Additionally, some of the features could be irrelevant in emotion detection and this leads to a decrease in the emotion recognition accuracy. To overcome this drawback, feature optimization can be performed on the feature sets to obtain the most desirable emotional feature set before classifying the features. In this paper, semi-nonnegative matrix factorization (semi-NMF) …
Determination Of Distance Between Dc Traction Power Centers In A 1500-V Dc Subway Line With Artificial Intelligence Methods, Mehmet Taci̇ddi̇n Akçay, İlhan Kocaarslan
Determination Of Distance Between Dc Traction Power Centers In A 1500-V Dc Subway Line With Artificial Intelligence Methods, Mehmet Taci̇ddi̇n Akçay, İlhan Kocaarslan
Turkish Journal of Electrical Engineering and Computer Sciences
The electrification system in rail systems is designed with regard to the operating data and design parameters. While the electrification system is formed, the minimum voltage rating that the traction force requires during the operation needs to be provided. The highest value of the voltage drop occurring on the line is determined by the distance between power centers. This value needs to be kept within certain limits for the continuity of operation. In this study, the determination of the distance between DC traction power centers for a 1500-V DC-fed rail system is done by means of the adaptive neuro-fuzzy inference …
Fitting A Recurrent Dynamical Neural Network To Neural Spiking Data: Tackling The Sigmoidal Gain Function Issues, Reşat Özgür Doruk
Fitting A Recurrent Dynamical Neural Network To Neural Spiking Data: Tackling The Sigmoidal Gain Function Issues, Reşat Özgür Doruk
Turkish Journal of Electrical Engineering and Computer Sciences
This is a continuation of a recent study (Doruk RO, Zhang K. Fitting of dynamic recurrent neural network models to sensory stimulus-response data. J Biol Phys 2018; 44: 449-469), where a continuous time dynamical recurrent neural network is fitted to neural spiking data. In this research, we address the issues arising from the inclusion of sigmoidal gain function parameters to the estimation algorithm. The neural spiking data will be obtained from the same model as that of Doruk and Zhang, but we propose a different model for identification. This will also be a continuous time recurrent neural network, but with …
Robust Compressed Domain Watermarking Algorithm For Video Protection And Authentication In Noisy Channels, Naveen Cheggoju, Vishal Satpute
Robust Compressed Domain Watermarking Algorithm For Video Protection And Authentication In Noisy Channels, Naveen Cheggoju, Vishal Satpute
Turkish Journal of Electrical Engineering and Computer Sciences
This paper introduces a robust and noise-resilient compressed domain video watermarking technique for data authentication and copyright protection. In recent years, watermarking has emerged as an essential technique to be equipped with data transmission. The main challenge pertaining to transmission is to protect the watermark from noise introduced by the channel. Here, we address this issue by watermark replication and by using the independent pass coding (INPAC) algorithm for compression. A replicated watermark is embedded into the video by the proposed blind video watermarking algorithm and then the watermarked video is compressed by the INPAC algorithm. The compressed video is …
Effect Of Some Immunomodulators And Zeatin On Susceptibility Of Wheat To Powdery Mildew, Alexander Babosha
Effect Of Some Immunomodulators And Zeatin On Susceptibility Of Wheat To Powdery Mildew, Alexander Babosha
Turkish Journal of Botany
The effects of zeatin, salicylic acid, and plant oligoadenylates on susceptibility of wheat seedlings to powdery mildew and the shape of dose-response curves for immunomodulation were studied. Salicylic acid and zeatin produced complex dose-responses with upregulation or downregulation of plant susceptibility. Under different experimental conditions, the dose-response curve for zeatin varied in shape from a curve with a maximum to a curve with a minimum of susceptibility to powdery mildew. More complicated curves with a resistance region framed with regions of increased susceptibility were also found. Plant oligoadenylates inhibited the development of powdery mildew at optimal concentrations. The increasing concentrations …
Contributions To The Hypericum L. Section Oligostema (Boiss.) Stef. (Hypericaceae), And Hypericum Turcicum Sp. Nov. As A New Species From Turkey, Mehmet Ufuk Özbek, Murat Koç, Ergi̇n Hamzaoğlu
Contributions To The Hypericum L. Section Oligostema (Boiss.) Stef. (Hypericaceae), And Hypericum Turcicum Sp. Nov. As A New Species From Turkey, Mehmet Ufuk Özbek, Murat Koç, Ergi̇n Hamzaoğlu
Turkish Journal of Botany
Hypericum turcicum (Hypericaceae) is described and illustrated as a new species from Beypazarı in Ankara Province in Northwest Anatolia, Turkey. The new species belongs to the section Oligostema, and it is closely related to H. aucheri. Diagnostic characters, description, detailed illustrations, ecology, and pollen and seed morphology are presented in this study. In addition, this study evaluates H. kazdaghense, which was previously accepted as a synonym of H. aucheri, as a distinct species and discusses the similarities and differences between H. turcicum and H. aucheri.
Regulation Of Boron Toxicity Responses Via Glutathione-Dependent Detoxification Pathways At Biochemical And Molecular Levels In Arabidopsis Thaliana, Doğa Seli̇n Kayihan, Ceyhun Kayihan, Yelda Özden Çi̇ftçi̇
Regulation Of Boron Toxicity Responses Via Glutathione-Dependent Detoxification Pathways At Biochemical And Molecular Levels In Arabidopsis Thaliana, Doğa Seli̇n Kayihan, Ceyhun Kayihan, Yelda Özden Çi̇ftçi̇
Turkish Journal of Botany
The fine-tuned regulation of the Halliwell-Asada cycle (ascorbate-glutathione pathway) in Arabidopsis thaliana under boron (B) toxicity was shown in our previous report. In this study, we investigated the expression levels of some members of the glutathione S-transferase (GST) superfamily, such as phi (GSTF2, GSTF6, GSTF7, and GSTF8), tau (GSTU19), and zeta (GSTZ1) classes in Arabidopsis thaliana that were exposed to 1 mM boric acid (1B) and 3 mM boric acid (3B). Additionally, the expression levels of genes for glutathione (GSH) and phytochelatin biosynthesis as well as miR169 and miR156 were evaluated in Arabidopsis thaliana exposed to 1B and 3B. Moreover, …
Effects Of The Feeds Containing Hazelnut Meal As Plant Protein Source On Growth Performance And Body Composition Of Siberian Sturgeon (Acipenser Baeri) And Economic Profitability Value, Huri̇ye Ariman Karabulut, İlker Zeki̇ Kurtoğlu, Yunus Emre Kirtan
Effects Of The Feeds Containing Hazelnut Meal As Plant Protein Source On Growth Performance And Body Composition Of Siberian Sturgeon (Acipenser Baeri) And Economic Profitability Value, Huri̇ye Ariman Karabulut, İlker Zeki̇ Kurtoğlu, Yunus Emre Kirtan
Turkish Journal of Veterinary & Animal Sciences
In this study, the effects of feeding with the diets containing hazelnut meal (HM) at different levels (0%, 15%, 30%, and 45%) on the growth performance and body composition of Siberian sturgeon were investigated. The study was carried out for 90 days with 3 replicates (n = 15; 283.1 ± 6.52 g fish weight). The highest weight gain (180.62 ± 2.84%) was observed in the control group followed by 15%, 30%, and 45% HM. When the groups were evaluated in terms of SGR, FCR, and PER, the control group was observed to have the best performance. The control group and …
Methods Of Diagnosis And Treatment Of Postpartum Uterine Infection Adopted By Algerian Veterinarians, Hamza Rahab, Alessandro Ricci, Ahmed Kasseh-Laouar, Christian Hanzen
Methods Of Diagnosis And Treatment Of Postpartum Uterine Infection Adopted By Algerian Veterinarians, Hamza Rahab, Alessandro Ricci, Ahmed Kasseh-Laouar, Christian Hanzen
Turkish Journal of Veterinary & Animal Sciences
The present study aimed to monitor the practices of Algerian veterinarians in the diagnosis and treatment of puerperal metritis (PM) and clinical endometritis (CE) in cattle. For this purpose, a questionnaire was established and distributed to collect the information concerning veterinarian profiles and practices related to the diagnosis and treatment of PM and CE. The results showed that examinations of the uterus (rectal palpation), vaginal discharge, and rectal temperature were the most practiced methods for PM (71%, 68%, and 83%, respectively) and CE (86%, 60%, and 65%, respectively) diagnosis. Tetracycline was the antibiotic of choice for intrauterine treatment of PM …
Accumulation And Histological Transformation In The Gills, Liver, Muscles, And Skin In Oreochromis Niloticus Induced By Mercury, Khalid Abdullah Al-Ghanim, Zubair Ahmad, Hmoud Fares Alkahem Al-Balawi, Fahad Al-Misned, Shahid Mahboob, El Amin Mohammad Suliman
Accumulation And Histological Transformation In The Gills, Liver, Muscles, And Skin In Oreochromis Niloticus Induced By Mercury, Khalid Abdullah Al-Ghanim, Zubair Ahmad, Hmoud Fares Alkahem Al-Balawi, Fahad Al-Misned, Shahid Mahboob, El Amin Mohammad Suliman
Turkish Journal of Veterinary & Animal Sciences
Specimens of Oreochromis niloticus (One control and 3 experimental groups) were fed diets mixed with different doses of mercury (control group = free of mercury; group 1 = 500 mg/kg; group 2 = 750 mg/kg, and group 3 = 1000 mg/kg) for 60 days in order to study its accumulation and histopathological alterations in the liver, gills, skeletal muscles, and skin. The results obtained revealed that mercury accumulation was significantly (P < 0.05) high in the liver and gills compared to the muscles and skin. The order of accumulation in these organs revealed to be liver > gills > muscles > skin. The fish fed various doses of mercury also showed histological alterations in these organs. Epithelial lifting and epithelial hypertrophy were seen in the gills of the …
Evaluation Of Milk Glutathione Peroxidase And Superoxide Dismutase Levels In Subclinical Mastitis In Damascus Goats, İsfendi̇yar Darbaz, Seçki̇n Salar, Serkan Sayiner, İdi̇l Baştan, Osman Ergene, Ayhan Baştan
Evaluation Of Milk Glutathione Peroxidase And Superoxide Dismutase Levels In Subclinical Mastitis In Damascus Goats, İsfendi̇yar Darbaz, Seçki̇n Salar, Serkan Sayiner, İdi̇l Baştan, Osman Ergene, Ayhan Baştan
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to evaluate milk glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels in Damascus goats with subclinical mastitis. According to the somatic cell counts (SCCs), 193 Damascus goats included in the study were divided into healthy (n = 75; SCC 0.05). In summary, a significant increase in GPx and decrease in SOD levels, respectively, were determined in goat milk samples with subclinical mastitis, and these changing trends were correlated with milk SCCs. However, age, parity, and number of offspring were not associated with these changing patterns.
Proliferation Effects Of Phenylboronic Acid And Boric Acid On Canine Peripheral Blood Mononuclear Cells, Uçkun Sai̇t Uçan, Zafer Sayin
Proliferation Effects Of Phenylboronic Acid And Boric Acid On Canine Peripheral Blood Mononuclear Cells, Uçkun Sai̇t Uçan, Zafer Sayin
Turkish Journal of Veterinary & Animal Sciences
The effects of phenylboronic acid (PBA) and boric acid (BA) on the proliferation of canine peripheral blood mononuclear cells (PBMCs) were investigated. Treatment of PBMCs from mixed breed dogs with PBA or BA (0.05 µg/mL) alone elicited blastogenic responses of 0.478 ± 0.438 and 0.499 ± 0.366, respectively. We observed an additive effect on proliferation when purebred Kangal PBMCs were cultured in a combination of BA (0.001 µg/mL) and the mitogenic lectin concanavalin A (1 µg/mL). However, the effects were not statistically significant. We detected varied IL-2 and IL-4 secretion in response to stimulation with boron-containing compounds. Our findings suggest …
Effects Of The Inclusion Of Detoxified Argan Press Cake In The Diet Of Dairy Goats On Milk Production And Milk Quality, Nazha Lakram, Sana Moutik, Ikram Mercha, El Haj El Maadoudi, Rachid Kabbour, Ahmed Douaik, Abdelmajid Zouahri, Abdelah El Housni, Mariam Naciri
Effects Of The Inclusion Of Detoxified Argan Press Cake In The Diet Of Dairy Goats On Milk Production And Milk Quality, Nazha Lakram, Sana Moutik, Ikram Mercha, El Haj El Maadoudi, Rachid Kabbour, Ahmed Douaik, Abdelmajid Zouahri, Abdelah El Housni, Mariam Naciri
Turkish Journal of Veterinary & Animal Sciences
This study was carried out to assess the effect of the incorporation of detoxified argan press cake on milk yield, physicochemical composition, and microbial quality of raw Alpine goat milk produced in the Meskala-Essaouira region of southwestern Morocco. The detoxification method, adopted for the removal of saponin present in the argan press cake, succeeded in reducing these antinutrients from 4.56 to 0.4 mg/g, allowing it to be used as livestock feed. The average of milk production increased by 24% for the detoxified argan press cake (DAPC) group compared to the argan press cake and local diet groups. The diets and …
Genetic Analysis Of Iranian Mycoplasma Gallisepticum Isolates Using Gene-Targeted Sequencing Of Complete Pvpa Gene, Naghmeh Kabiri, Mohsen Bashashati, Mehdi Vasfi Marandi, Mansour Banani, Fereshteh Sabouri
Genetic Analysis Of Iranian Mycoplasma Gallisepticum Isolates Using Gene-Targeted Sequencing Of Complete Pvpa Gene, Naghmeh Kabiri, Mohsen Bashashati, Mehdi Vasfi Marandi, Mansour Banani, Fereshteh Sabouri
Turkish Journal of Veterinary & Animal Sciences
This study aims to evaluate Mycoplasma gallisepticum (MG) genetic diversity through the complete sequencing of the pvpA gene among six MG isolates present in industrial poultry from 2015 to 2016. The genetic comparison of these six isolates showed similarities of over 94% and 92% in terms of nucleotide and amino acid sequences, respectively. The size of the PvpA protein in the studied isolates included three different sizes with 361, 364, and 366 amino acids. The carboxy-terminus of the studied PvpA proteins contained 11 tetrapeptides of P-R-P-M/Q/N motifs with truncation in the proline-rich region. Based on the BLAST analysis, the pvpA …
Isolation And Molecular Characterization Of Salmonella Enterica And Escherichia Coli From Poultry Samples, Ayli̇n Cesur, Saci̇de Özlem Ulutaş, Yeşi̇m Soyer
Isolation And Molecular Characterization Of Salmonella Enterica And Escherichia Coli From Poultry Samples, Ayli̇n Cesur, Saci̇de Özlem Ulutaş, Yeşi̇m Soyer
Turkish Journal of Veterinary & Animal Sciences
Innumerable foodborne pathogens including Salmonella and Escherichia coli pose a serious threat to human health and food safety. As perishable foods, poultry products are considered one of the most common sources of foodborne pathogens including Salmonella and E. coli due to transmission of drug resistance, dissemination of organisms, and cross-contamination. In our study, phenotypic and genotypic characterizations of Salmonella enterica and E. coli isolated from packaged raw chicken products were carried out. Samples belonging to different commercial brands were collected in Ankara in 2015. Among 15 out of 19 Salmonella enterica subsp. enterica strains isolated from different and/or same poultry …
Microborings As Indication Of Cryptic Life Modes In The Foraminifer Orbitoides:Maastrichtian Sediments Of The Haymana And Nallıhan Districts (Ankara, Turkey), Muhi̇tti̇n Görmüş, Huri̇ye Demi̇rcan, Yusuf Kağan Kadioğlu, Fuzuli̇ Yağmurlu, Muhammed Sami̇ Us
Microborings As Indication Of Cryptic Life Modes In The Foraminifer Orbitoides:Maastrichtian Sediments Of The Haymana And Nallıhan Districts (Ankara, Turkey), Muhi̇tti̇n Görmüş, Huri̇ye Demi̇rcan, Yusuf Kağan Kadioğlu, Fuzuli̇ Yağmurlu, Muhammed Sami̇ Us
Turkish Journal of Earth Sciences
Widespread Maastrichtian siliciclastics and carbonates cropping out in the Haymana (S Ankara) and Nallıhan (NW Ankara) districts in the northwest and central Anatolia basins include rich Orbitoides occurrences. Microborings in the Orbitoides tests are interesting to notify. In this study, the details of their morphologic structures were investigated. Microborings were analyzed in more than 650 equatorial thin sections of the Orbitoides tests and 100 hard rock thin sections. The abundance of microborings increases in the siliciclastics towards the Cretaceous/Palaeogene boundary (K/Pg). They were identified as Maeandropolydora osmaneliensis Nielsen and Görmüş, Maeandropolydora isp. Curvichnus semorbis Nielsen, Oichnus simplex Bromley, Oichnus isp. …
Response Of Breast Cancer Cells To Ifnî±-2b In 2d And 3d Cell Cultures, Tetiana Herheliuk, Olena Perepelytsina, Andrij Ugnivenko, Lyudmila Ostapchenko, Mychailo Sydorenko
Response Of Breast Cancer Cells To Ifnî±-2b In 2d And 3d Cell Cultures, Tetiana Herheliuk, Olena Perepelytsina, Andrij Ugnivenko, Lyudmila Ostapchenko, Mychailo Sydorenko
Turkish Journal of Biology
The effect of IFNα-2b on the migration, proliferation, and expression of epithelial and mesenchymal markers of MCF-7 tumor adenocarcinoma cells in 2D and 3D cell cultures was examined. A significant cytostatic effect of IFNα-2b on the tumor population was detected. It was found that changes in the expression of epithelial (CKs and EpCAM) and mesenchymal markers were caused by changing the growth type of the tumor population. IFNα-2b inhibited migration of tumor cells to the suspension fraction and promoted an increase in expression of CK and EpCAM in 2D and 3D cell cultures, but only in the 3D culture was …
Transcriptome Analysis Reveals Differentially Expressed Genes Between Human Primary Bone Marrow Mesenchymal Stem Cells And Human Primary Dermal Fibroblasts, Eki̇m Z. Taşkiran, Beren Karaosmanoğlu
Transcriptome Analysis Reveals Differentially Expressed Genes Between Human Primary Bone Marrow Mesenchymal Stem Cells And Human Primary Dermal Fibroblasts, Eki̇m Z. Taşkiran, Beren Karaosmanoğlu
Turkish Journal of Biology
Stromal cells have been widely used in biomedical research and disease modeling studies in vitro. The most commonly used types of stromal cells are mesenchymal stem cells and fibroblasts. Their cellular phenotypes and differentiation capabilities are quite similar and there are no specific distinction criteria. In order to identify transcriptomic differences between these 2 cell types, we performed next-generation RNA sequencing. Using the global gene expression profile and pathway analysis, we showed that human primary bone marrow mesenchymal stem cells and human primary dermal fibroblasts have different molecular signatures. We also identified critical transcription factors that are differentially expressed between …
Genome And Metabolome Mining Of Marine Obligate Salinispora Strains To Discover New Natural Products, Süleyman Özakin, Ebru İnce Bostanci
Genome And Metabolome Mining Of Marine Obligate Salinispora Strains To Discover New Natural Products, Süleyman Özakin, Ebru İnce Bostanci
Turkish Journal of Biology
Marine microorganisms are receiving more attention as a promising potential source of new natural products. In the present study, we performed genomic and metabolomic analyses to explore the metabolic potential of the obligate marine actinomycete genus Salinispora. The genomes of thirty Salinispora strains were prospected in search of biosynthetic gene clusters including polyketide synthase (PKS), nonribosomal peptide synthetase (NPRS), terpene, indole, lantibiotics, and siderophores. We determined considerable diversity of natural product biosynthetic gene clusters in their genome. There were a total of 1428 putative gene clusters involved in the biosynthesis of various bioactive natural products. Furthermore, 1509 ketosynthase (KS) and …
Effects Of Notch Signalling On The Expression Of Sema3c, Hmga2, Cxcl14, Cxcr7, And Ccl20 In Breast Cancer, Cansu Küçükköse, Özden Yalçin Özuysal
Effects Of Notch Signalling On The Expression Of Sema3c, Hmga2, Cxcl14, Cxcr7, And Ccl20 In Breast Cancer, Cansu Küçükköse, Özden Yalçin Özuysal
Turkish Journal of Biology
Metastasis is the main reason for death in breast cancer. Understanding the molecular players in metastasis is crucial for diagnostic and therapeutic purposes. Notch signalling plays an oncogenic role in breast tumorigenesis and is involved in metastasis. Downstream mediators of Notch signalling in prometastatic processes are not yet fully discovered. Here we aimed to investigate whether Notch signalling regulates the expression of SEMA3C, HMGA2, CXCL14, CXCR7, and CCL20, which are involved in prometastatic processes, in breast cell lines. To this end, expression of the selected genes was analysed following Notch activation by overexpression of the Notch1 intracellular domain in the …
Complete Genome Sequence Analysis Of A Lytic Shigella Flexneri Vb_Sfls-Isf001 Bacteriophage, Khashayar Shahin, Majid Bouzari, Ran Wang
Complete Genome Sequence Analysis Of A Lytic Shigella Flexneri Vb_Sfls-Isf001 Bacteriophage, Khashayar Shahin, Majid Bouzari, Ran Wang
Turkish Journal of Biology
Shigellosis is one of the most important acute enteric infections caused by different species of Shigella, such as Shigella flexneri. Despite the use of antibiotic therapy to reduce disease duration, this approach is becoming less effective due to the emergence of antibiotic resistance among Shigella spp. Bacteriophages have been introduced as an alternative for controlling shigellosis. However, the bacteriophages must be without any lysogenic or virulence factors, toxin coding, or antibiotic-resistant genes. In this study, the whole genome sequence of vB_SflS-ISF001, a virulent Siphoviridae bacteriophage specific for Shigella flexneri, was obtained, and a comparative genomic analysis was carried out to …
Identification Of Bioactive Compounds From Fraxinus Angustifolia Extracts With Anti-Nadh Oxidase Activity Of Bovine Milk Xanthine Oxidoreductase, Nadjia Ahmane, Dina Atmani-Kilani, Nassima Chaher, Karima Ayouni, Meriem Rahmani-Berboucha, Gregory Da Costa, Nadjet Debbache-Benaida, Tristan Richard, Djebbar Atmani
Identification Of Bioactive Compounds From Fraxinus Angustifolia Extracts With Anti-Nadh Oxidase Activity Of Bovine Milk Xanthine Oxidoreductase, Nadjia Ahmane, Dina Atmani-Kilani, Nassima Chaher, Karima Ayouni, Meriem Rahmani-Berboucha, Gregory Da Costa, Nadjet Debbache-Benaida, Tristan Richard, Djebbar Atmani
Turkish Journal of Biology
Fraxinus angustifolia leaves and bark are used in traditional medicine against various inflammatory-related pathologies incumbent to reactive oxygen species (ROS) generation by the NADH oxidase activity of enzymes such as xanthine oxidoreductase (XOR). This study was designed to investigate the in vitro and in vivo inhibitory activities of this enzyme by Fraxinus angustifolia extracts. The leaf organic phase of ethyl acetate (LFA) and its bark aqueous counterpart (BFA) showed the strongest anti-NADH oxidase activity in vitro (IC50 = 38.51 and 42.04 μg mL-1, respectively). They consequently suppressed superoxide generation both enzymatically (53% and 19%, respectively) and nonenzymatically (34% and 19%, …
Functional Characteristics Of Lactobacilli From Traditional Bulgarian Fermented Milk Products, Veronica Nemska, Petya Logar, Tanya Rasheva, Zdravka Sholeva, Nelly Georgieva, Svetla Danova
Functional Characteristics Of Lactobacilli From Traditional Bulgarian Fermented Milk Products, Veronica Nemska, Petya Logar, Tanya Rasheva, Zdravka Sholeva, Nelly Georgieva, Svetla Danova
Turkish Journal of Biology
After oral administration, probiotic lactobacilli meet a number of protection systems in the human body, such as exposure to gastric, pancreatic, and small intestinal juices. Overcoming these detrimental barriers allows living bacteria to adhere to the intestinal epithelium and permanently colonize the gastrointestinal tract (GIT), providing health benefits to the host. Based on this, the transit tolerance of 25 candidate probiotic lactobacilli from katak, yoghurt, and white-brined and yellow cheese to simulated bile and small intestinal juices of variable pH was investigated. To establish their resistance, in vitro model systems based on modified MRS media and a longer duration of …