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A Random Subspace Based Conic Functions Ensemble Classifier, Emre Çi̇men
A Random Subspace Based Conic Functions Ensemble Classifier, Emre Çi̇men
Turkish Journal of Electrical Engineering and Computer Sciences
Classifiers overfit when the data dimensionality ratio to the number of samples is high in a dataset. This problem makes a classification model unreliable. When the overfitting problem occurs, one can achieve high accuracy in the training; however, test accuracy occurs significantly less than training accuracy. The random subspace method is a practical approach to overcome the overfitting problem. In random subspace methods, the classification algorithm selects a random subset of the features and trains a classifier function trained with the selected features. The classification algorithm repeats the process multiple times, and eventually obtains an ensemble of classifier functions. Conic …
Net-Lda: A Novel Topic Modeling Method Based On Semantic Document Similarity, Eki̇n Eki̇nci̇, Sevi̇nç İlhan Omurca
Net-Lda: A Novel Topic Modeling Method Based On Semantic Document Similarity, Eki̇n Eki̇nci̇, Sevi̇nç İlhan Omurca
Turkish Journal of Electrical Engineering and Computer Sciences
Topic models, such as latent Dirichlet allocation (LDA), allow us to categorize each document based on the topics. It builds a document as a mixture of topics and a topic is modeled as a probability distribution over words. However, the key drawback of the traditional topic model is that it cannot handle the semantic knowledge hidden in the documents. Therefore, semantically related, coherent and meaningful topics cannot be obtained. However, semantic inference plays a significant role in topic modeling as well as in other text mining tasks. In this paper, in order to tackle this problem, a novel NET-LDA model …
Peri-Net: A Parameter Efficient Residual Inception Network For Medical Imagesegmentation, Fatmatülzehra Uslu, Cher Bass, Anil A. Bharath
Peri-Net: A Parameter Efficient Residual Inception Network For Medical Imagesegmentation, Fatmatülzehra Uslu, Cher Bass, Anil A. Bharath
Turkish Journal of Electrical Engineering and Computer Sciences
Recent developments in deep networks allow us to train networks with more parameters by yielding better performance given sufficient amount of data. However, we are still restricted with the availability of labelled data in medical image segmentation, where the problem is exacerbated with high intra- and intervariability of anatomical structures. In order to bypass this problem without compromising network performance, this study introduces a PERINet, which promises to achieve higher performance while being with smaller parameter count such as on the order of 0.8 million than its counterparts. The network benefits from rich features generated by our versions of inception …
Fiber Optic Chemical Sensors For Water Testing By Using Fiber Loop Ringdown Spectroscopy Technique, Mali̇k Kaya
Fiber Optic Chemical Sensors For Water Testing By Using Fiber Loop Ringdown Spectroscopy Technique, Mali̇k Kaya
Turkish Journal of Electrical Engineering and Computer Sciences
Real-time response, low cost, sensitive and easy setup fiber optic chemical sensors were fabricated by etching a part of single mode fiber in hydrofluoric (HF) acid solution and tested in different water samples such as tap water, DI water, salty and sugar water with different concentrations to record ringdown time (RDT) differences between media due to refractive index differences by employing the fiber loop ringdown (FLRD) spectroscopy technique. Baseline stability of 0.63 % and the minimum detectable RDT of $5.05$ $\mu$s for this kind of fiber optic chemical sensors were obtained. Fabricated sensors were coated with N,N-Diethyl-p-phenylenediamine for the first …
The Role Of Badh Gene In Oxidative, Salt, And Drought Stress Tolerances Of White Clover, Gürkan Demi̇rkol
The Role Of Badh Gene In Oxidative, Salt, And Drought Stress Tolerances Of White Clover, Gürkan Demi̇rkol
Turkish Journal of Botany
The aim of this study was to confirm the presence of BADH gene and control whether it plays an important role to protect white clover (Trifolium repens L.) against oxidative, salt, and drought stresses. Three genotypes possessing BADH and 1 genotype lacking BADH were selected, considering the expression levels of BADH in response to methyl viologen mediated oxidative stress. The genotypes possessing BADH displayed significantly less ion leakage under oxidative stress treatment, compared to that lacking BADH . In order to test salinity tolerance, the plants were treated with 300 mM NaCl for 2 weeks, and to mimic drought conditions, …
Karyotype Evolution And New Chromosomal Data In Erodium: Chromosome Alteration, Polyploidy, Dysploidy, And Symmetrical Karyotypes, Esra Marti̇n, Ahmet Kahraman, Tuncay Di̇rmenci̇, Havva Bozkurt, Hali̇l Erhan Eroğlu
Karyotype Evolution And New Chromosomal Data In Erodium: Chromosome Alteration, Polyploidy, Dysploidy, And Symmetrical Karyotypes, Esra Marti̇n, Ahmet Kahraman, Tuncay Di̇rmenci̇, Havva Bozkurt, Hali̇l Erhan Eroğlu
Turkish Journal of Botany
Chromosomal data are valuable and very useful for revealing evolution and speciation processes. Due to its wide distribution throughout the world, morphological differences, and chromosomal alterations, Erodium L?Hér. is an important genus for investigating the relationship between chromosomal alterations and karyotype evolution. In the present study, the chromosome records of 15 taxa are provided; three are reported here for the first time (E.birandianum, E. gaillardotii, and E.hendrikii), seven present new chromosome numbers, and five are in agreement with previous reports. Karyotype evolution is summarized in the light of this data, and four different genomes are presented in the genus. Millions …
Transcriptomic Insights Into The Molecular Aspects Of Salt Stress Responses In Kandelia Candel Roots, Jianhong Xing, Dezhuo Pan, Lingxia Wang, Fanglin Tan, Wei Chen
Transcriptomic Insights Into The Molecular Aspects Of Salt Stress Responses In Kandelia Candel Roots, Jianhong Xing, Dezhuo Pan, Lingxia Wang, Fanglin Tan, Wei Chen
Turkish Journal of Botany
The mangrove plant Kandelia candel is a type of woody halophyte that grows in tropical and subtropical ocean intertidal zones and exhibits a high salt tolerance. In this study, 61,970 unigenes were obtained from the roots of 60-day-old K. candel seedlings treated with 0 (control), 200, 400, and 600 mM NaCl for 3 days with an N50 of 1510 bp. Moreover, 454, 311, and 2663 genes were differentially expressed under 200, 400, and 600 mM NaCl treatments, respectively. These differentially expressed genes were primarily involved in plant hormone signal transduction, carbohydrate and energy metabolism, amino acid metabolism, stress response, and …
Effects Of Microalgal Biomass As Biofertilizer On The Growth Of Cucumber And Microbial Communities In The Cucumber Rhizosphere, Junping Lv, Shufang Liu, Jia Feng, Qi Liu, Jun Guo, Lige Wang, Xiaoyan Jiao, Shulian Xie
Effects Of Microalgal Biomass As Biofertilizer On The Growth Of Cucumber And Microbial Communities In The Cucumber Rhizosphere, Junping Lv, Shufang Liu, Jia Feng, Qi Liu, Jun Guo, Lige Wang, Xiaoyan Jiao, Shulian Xie
Turkish Journal of Botany
In the present study, microalgal biomass (Anabeana circinalis and Scenedesmus quadricauda) was used as biofertilizer in cucumber cultivation. The response of cucumber growth characters to microalgal biofertilizer was evaluated. Moreover, rhizosphere microbial diversity and community composition of cucumber was analyzed through 16S rRNA high-throughput Illumina sequencing data. The results showed that microalgal biomass as biofertilizer significantly promoted height, number of leaves and flower buds, and stem diameter of cucumber. The application of a high concentration of S. quadricauda to soil raised the diversity of rhizosphere fungi of cucumber. The rhizosphere microbial community of cucumber also responded to microalgal biofertilizer. The …
Critical Notes On Draconanthes Aberrans (Orchidaceae, Pleurothallidinae) With Description Of New Species, Marta Kolanowska, Slawomir Nowak, Dariusz Szlachetko
Critical Notes On Draconanthes Aberrans (Orchidaceae, Pleurothallidinae) With Description Of New Species, Marta Kolanowska, Slawomir Nowak, Dariusz Szlachetko
Turkish Journal of Botany
The actual variation and specific diversity of Neotropical Draconanthes aberrans is evaluated based on morphological data. As recognized in this paper D.aberrans complex includes a total of 6 species, 3 of which are described here. New combinations are proposed for Lepanthes prionota and L. trachysepala. Two species, including D. aberrans, are lectotypified. The previous incorrect typifications are discussed. Each of 6 species is morphologically characterized. The perianth segments of all discussed taxa are illustrated. The key to identification of species belonging to the Draconanthes aberrans complex is presented together with the comparative morphology of studied taxa.
In Silico Adme Predictions And In Vitro Antibacterial Evaluation Of 2-Hydroxy Benzothiazole-Based 1,3,4-Oxadiazole Derivatives, Afnan Ahmed Alghamdi, Mohammad Mahboob Alam, Syed Nazreen
In Silico Adme Predictions And In Vitro Antibacterial Evaluation Of 2-Hydroxy Benzothiazole-Based 1,3,4-Oxadiazole Derivatives, Afnan Ahmed Alghamdi, Mohammad Mahboob Alam, Syed Nazreen
Turkish Journal of Chemistry
In the present work, a library of fifteen 2-hydroxy benzothiazole-linked 1,3,4 -oxadiazole derivatives have been synthesized and confirmed using different analytical techniques. All of the synthesized compounds have been tested for antibacterial and in silico pharmacokinetic studies for the first time. From the ADME predictions, compound 4 showed the highest in silico absorption percentage (86.77%), while most of the compounds showed more than 70% absorption. All of the compounds comply with the Lipinski rule of 5, suggesting that the compounds possess good drug likeness properties upon administration. Furthermore, all of the compounds follow the Veber rule, indicating good bioavailability and …
Fluorescent Sensing Platform For Low-Cost Detection Of Cu$^{\Mathbf{2+}}$ By Coumarin Derivative: Dft Calculation And Practical Application In Herbal And Black Tea Samples, Tahi̇r Savran, Abdurrahman Karagöz, Şükri̇ye Ni̇han Karuk Elmas, Duygu Aydin, Furkan Özen, Kenan Koran, Fatma Nur Arslan, Ahmet Orhan Görgülü, İbrahi̇m Yilmaz
Fluorescent Sensing Platform For Low-Cost Detection Of Cu$^{\Mathbf{2+}}$ By Coumarin Derivative: Dft Calculation And Practical Application In Herbal And Black Tea Samples, Tahi̇r Savran, Abdurrahman Karagöz, Şükri̇ye Ni̇han Karuk Elmas, Duygu Aydin, Furkan Özen, Kenan Koran, Fatma Nur Arslan, Ahmet Orhan Görgülü, İbrahi̇m Yilmaz
Turkish Journal of Chemistry
A fluorogenic probe based on a coumarin-derivative for Cu$^{2+}$ sensing in CH$_{3}$CN/H$_{2}$O media (v/v, 95/5, 5.0 \textmu M) was developed and applied in real samples. 3-(4-chlorophenyl)-6,7-dihydroxy-coumarin (MCPC) probe was obtained by synthetic methodologies and identified by spectral techniques. The probe MCPC showed remarkable changes with a ``turn-off'' fluorogenic sensing approach for the monitoring of Cu$^{2+}$ at 456 nm under an excitation wavelength of 366 nm. The response time of the probe MCPC was founded as only 1 min. The detection limit of the probe MCPC was recorded to be 1.47 nM. The binding constant and possible stoichiometric ratio (1:1) values …
Bis Benzothiophene Schiff Bases: Synthesis And In Silico-Guided Biological Activity Studies, Yasemi̇n Ünver, Di̇lek Ünlüer, Şahi̇n Di̇rekel, Serdar Durdaği
Bis Benzothiophene Schiff Bases: Synthesis And In Silico-Guided Biological Activity Studies, Yasemi̇n Ünver, Di̇lek Ünlüer, Şahi̇n Di̇rekel, Serdar Durdaği
Turkish Journal of Chemistry
Since benzo [$b$] thiophene scaffold is one of the privileged structures in drug discovery as this core exhibitsactivities for different biological problems, in this study bis (benzo[$b$]thiophene-2-yl) alkyl methanimine derivatives (1-9) were synthesized by reacting benzo[$b$]thiophene-2-carbaldehyde with diamines. All newly compounds were characterized by IR, $^{1}$H NMR and $^{13}$C NMR spectroscopic methods. Synthesized compounds were investigated using binary QSAR-based models on therapeutic activity prediction of synthesized compounds and they showed high predicted activities in following diseases: bacterial, angina, allergy, depression and obesity. Thus, they were then tested for their antimicrobial and antileishmanial activities as a result of this theoretical study. …
Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş
Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş
Turkish Journal of Chemistry
Schiff base derivatives with anthracene- and pyrene-based units, A1-A6 and P1-P6 were synthesized (89%-99% yields). Schiff base derivatives were designed to possess an heterocyclic moiety on one side to enhance the coordination ability towards metals. To investigate the biological assay of the newly synthesized compounds, their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, metal chelating, reducing power, antibacterial and DNA binding activities were tested. A6 (63.1%) showed the maximum free radical scavenging activity among all. However, compound P3 at concentration of 200 \textmu g/mL possessed the highest metal chelating (45.8%) activity and power of reduction. In addition, P3 and A6 showed antibacterial activity …
Effect Of Mg Doping On Morphology, Photocatalytic Activity And Related Biological Properties Of Zn$_{\Mathbf{1-X}}$ Mg$_{X}$ O Nanoparticles, Bestenur Yalçin, Doğan Akcan, İbrahi̇m Ertuğrul Yalçin, Mehmet Can Alphan, Kenan Şentürk, İbrahi̇m İlker Özyi̇ği̇t, Lütfi̇ Arda
Effect Of Mg Doping On Morphology, Photocatalytic Activity And Related Biological Properties Of Zn$_{\Mathbf{1-X}}$ Mg$_{X}$ O Nanoparticles, Bestenur Yalçin, Doğan Akcan, İbrahi̇m Ertuğrul Yalçin, Mehmet Can Alphan, Kenan Şentürk, İbrahi̇m İlker Özyi̇ği̇t, Lütfi̇ Arda
Turkish Journal of Chemistry
The objective of this study is to synthesize ZnO and Mg doped ZnO (Zn$_{1-x}$Mg$_{x}$O) nanoparticles via the sol-gel method, and characterize their structures and to investigate their biological properties such as antibacterial activity and hemolytic potential.Nanoparticles (NPs) were synthesized by the sol-gel method using zinc acetate dihydrate (Zn(CH$_{3}$COO)$_{2}$.2H$_{2}$O) and magnesium acetate tetrahydrate (Mg(CH$_{3}$COO)$_{2}$.4H$_{2}$O) as precursors. Methanol and monoethanolamine were used as solvent and sol stabilizer, respectively. Structural and morphological characterizations of Zn$_{1-x}$Mg$_{x}$O nanoparticles were studied by using XRD and SEM-EDX, respectively. Photocatalytic activities of ZnO and selected Mg-doped ZnO (Zn$_{1-x}$Mg$_{x}$O) nanoparticles were investigated by degradation of methylene blue (MeB). Results …
A Novel Molecular Imprinting Polymer For The Selective Adsorptionof D-Arabinitol From Spiked Urine, Yuni Retnaningtyas, Ganden Supriyanto, Ni Nyoman Tri Puspaningsih, Roedi Irawan, Siswandono Siswodihardjo
A Novel Molecular Imprinting Polymer For The Selective Adsorptionof D-Arabinitol From Spiked Urine, Yuni Retnaningtyas, Ganden Supriyanto, Ni Nyoman Tri Puspaningsih, Roedi Irawan, Siswandono Siswodihardjo
Turkish Journal of Chemistry
In this research, molecular imprinting polymers (MIPs) for D-arabinitol were synthesized using a bulk polymerization method through a noncovalent approach. The MIPs were prepared by using D-arabinitol as a template, acrylamide as a functional monomer, ethylene glycol dimethacrylateas cross-linker, benzoyl peroxide as an initiator and dimethyl sulfoxideas a porogen. MIPS was synthesized in several formulas with a different molar ratio of template to functional monomers and cross-linker. Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) were used to characterize the MIPs produced. A batch rebinding assay was used to test the binding efficiency of each formula. Batch rebinding test …
The Production Of Enantiomerically Pure 1-Phenylethanol By Enzymatic Kineticresolution Method Using Response Surface Methodology, Ayşe Bozan, Rahi̇me Songür, Ülkü Mehmetoğlu
The Production Of Enantiomerically Pure 1-Phenylethanol By Enzymatic Kineticresolution Method Using Response Surface Methodology, Ayşe Bozan, Rahi̇me Songür, Ülkü Mehmetoğlu
Turkish Journal of Chemistry
As the enantiomers of 1-phenylethanol are valuable intermediates in several industries, the lipase catalyzed kinetic resolution of (R,S) -1-phenylethanol is a relevant research topic. In this study, the goal was to determine the optimum reaction parameters to produce enantiomerically pure 1-phenylethanol by lipase (Novozyme 435) catalyzed kinetic resolution using response surface methodology (RSM). Reactions were performed with 40-400 mM (R,S)-1-phenylethanol, 120-1200 mM vinyl acetate and 2-22 mg/ mL biocatalyst concentrations (BC$_{L}$), at 20-60 °C and with a stirring rate of 50-400 rpm for 5-120 min. The samples were analyzed using high performance liquid chromatography (HPLC) with a Chiralcel OB column. …
Mathematical Modeling Of A Continuous-Flow Packed-Bed Reactor With Immobilizedlipase For Kinetic Resolution Of (R,S)-2-Pentanol, Asli Soyer Malyemez, Abdulwahap Giwa, Emi̇ne Bayraktar, Ülkü Mehmetoğlu
Mathematical Modeling Of A Continuous-Flow Packed-Bed Reactor With Immobilizedlipase For Kinetic Resolution Of (R,S)-2-Pentanol, Asli Soyer Malyemez, Abdulwahap Giwa, Emi̇ne Bayraktar, Ülkü Mehmetoğlu
Turkish Journal of Chemistry
In this study, the kinetic resolution of (R,S)-2-pentanol via transesterification to achieve S-2-pentanol, a key intermediate required in the synthesis of anti-Alzheimer drugs, was investigated in continuous-flow packed-bed reactors. The effects of residence time, substrate concentration, and operation time of the enzyme were investigated. Under steady state conditions, 50% conversion and enantiomeric excess of the substrate (ee$_{S}$)>99% were achieved at a residence time of 0.04 min. Productivity of the continuous-flow process (1.341 mmol/min/g)was about 4 times higher than that of the corresponding batch process (0.363 mmol/min/g). In addition, the mathematical modeling of the packed-bed reactor was conductedusing an axial …
Application Of Synthesized Copper Nanoparticles Using Aqueous Extract Ofziziphus Mauritiana L. Leaves As A Colorimetric Sensor For The Detection Of Ag$^{+}$, Roomia Memon, Ayaz Ali Memon, Syed Tufail Hussain Sherazi, Siraj Uddin, Aamna Balouch, Muhammad Raza Shah, Sarfaraz Ahmed Mahesar, Kauser Rajar, Muhammad Hassan Agheem
Application Of Synthesized Copper Nanoparticles Using Aqueous Extract Ofziziphus Mauritiana L. Leaves As A Colorimetric Sensor For The Detection Of Ag$^{+}$, Roomia Memon, Ayaz Ali Memon, Syed Tufail Hussain Sherazi, Siraj Uddin, Aamna Balouch, Muhammad Raza Shah, Sarfaraz Ahmed Mahesar, Kauser Rajar, Muhammad Hassan Agheem
Turkish Journal of Chemistry
The presented work demonstrates the preparation of copper nanoparticles (CuNPs) via aqueous leaves extract of Ziziphus mauritiana L. (Zm) using hydrazine as a reducing agent. Various parameters such as volume of extract, concentration of hydrazine hydrate, concentration of copper chloride, and pH of the solution were optimized to obtain Ziziphus mauritiana L. leaves extract derived copper nanoparticles (Zm-CuNPs). Brownish red color was initial indication of the formation of Zm-CuNPs while it was confirmed by surface plasmon resonance (SPR) band at wavelength of 584 nm using ultraviolet-visible (UV-vis) spectroscopy. Synthesized Zm-CuNPs were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron …
Design, Synthesis, And Spasmolytic Activity Of Thiophene-Based Derivatives Via Suzukicross-Coupling Reaction Of 5-Bromothiophene-2-Carboxylic Acid: Their Structural Andcomputational Studies, Nasir Rasool, Hafiz Mansoor Ikram, Ammara Rashid, Nazia Afzal, Muhammad Ali Hashmi, Muhammad Naeem Khan, Ayesha Khan, Imran Imran, Hafiz Muhammad Abdur Rahman, Syed Adnan Ali Shah
Design, Synthesis, And Spasmolytic Activity Of Thiophene-Based Derivatives Via Suzukicross-Coupling Reaction Of 5-Bromothiophene-2-Carboxylic Acid: Their Structural Andcomputational Studies, Nasir Rasool, Hafiz Mansoor Ikram, Ammara Rashid, Nazia Afzal, Muhammad Ali Hashmi, Muhammad Naeem Khan, Ayesha Khan, Imran Imran, Hafiz Muhammad Abdur Rahman, Syed Adnan Ali Shah
Turkish Journal of Chemistry
In the current research work, a facile synthesis of a series of novel thiophene-based derivatives of 5-bromothiophene-2- carboxylic acid (1) have been synthesized. All analogs (5a-5e, 10a-10f) were obtained from the coupling reaction of 5-bromothiophene- 2-carboxylic acid (1) and different arylboronic acids with moderate-to-good yields under controlled and optimal conditions. The structures of the newly synthesized compounds were characterized through spectral analysis and their spasmolytic activity, and most of the compounds exhibited potentially good spasmolytic effect. Among the synthesized analogs, compound phenethyl 5-(3,4-dichlorophenyl)thiophene-2-carboxylate (10d) particular showed an excellent spasmolytic effect with an EC$_{50}$ value of 1.26. All of the compounds …
Magnetite Nanoparticles-Based Hydroxyl Radical Scavenging Activity Assay Ofantioxidants Using N, N-Dimethyl-P-Phenylenediamine Probe, Zi̇ya Can, Büşra Keski̇n, Ayşem Arda, Erol Erçağ, Mustafa Reşat Apak
Magnetite Nanoparticles-Based Hydroxyl Radical Scavenging Activity Assay Ofantioxidants Using N, N-Dimethyl-P-Phenylenediamine Probe, Zi̇ya Can, Büşra Keski̇n, Ayşem Arda, Erol Erçağ, Mustafa Reşat Apak
Turkish Journal of Chemistry
Excessive amounts of reactive oxygen species (ROS), unless counterbalanced by antioxidants, can cause cellular damage under oxidative stress conditions; therefore, antioxidative defenses against ROS must be measured. With the development of nanotechnology, nanoparticles have found numerous applications in science, health, and industries. Magnetite nanoparticles (Fe$_{3}$O$_{4}$:MNPs) have attracted attention because of their peroxidase-like activity. In this study, hydroxyl radicals (?OH) generated by MNPs-catalyzed degradation of H$_{2}$O$_{2}$ converted the N,N-dimethyl-p-phenylenediamine (DMPD) probe into its colored DMPD$^{•+}$ radical cation, which gave an absorbance maximum at λ = 553 nm. In the presence of antioxidants, $^{•}$OH was partly scavenged by antioxidants and produced less …
Catalytic Activity Of Novel Thermoplastic/Cellulose-Au Nanocomposites Prepared By Cryomilling, Joanna Kwiczak Yigitbasi
Catalytic Activity Of Novel Thermoplastic/Cellulose-Au Nanocomposites Prepared By Cryomilling, Joanna Kwiczak Yigitbasi
Turkish Journal of Chemistry
Due to environmental concerns, increasing attention has been focused on the application and preparation of biobased polymers and their blends. In this study, cellulose, the most spread biopolymer on Earth, was used in the preparation of novel cotton/polypropylene- Au and cotton/polyethylene-Au nanocomposites via a green mechanochemical approach. First, mechanoradicals were generated by ball milling of the cotton and thermoplastics under cryo conditions, and then, these radicals were used in the reduction of Au ions to Au nanoparticles (Au NPs). Nanocomposites were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The application of mechanochemistry in …
Newly Synthesized Peripherally Octa-Substituted Zinc Phthalocyanines Carrying Halogenterminated Phenoxy-Phenoxy Moiety: Comparative Photochemical And Photophysicalfeatures, Erkan Kirbaç, Ali̇ Erdoğmuş
Newly Synthesized Peripherally Octa-Substituted Zinc Phthalocyanines Carrying Halogenterminated Phenoxy-Phenoxy Moiety: Comparative Photochemical And Photophysicalfeatures, Erkan Kirbaç, Ali̇ Erdoğmuş
Turkish Journal of Chemistry
This study reports the 3 new phthalonitrile derivatives, namely 4, 5 Bis-[4-(4-bromophenoxy) phenoxy] phthalonitrile (1), 4,5 Bis-[4-(4-chlorophenoxy) phenoxy]phthalonitrile (2), and 4, 5 Bis[4-(4-fluorophenoxy) phenoxy] phthalonitrile (3). Their octasubstituted zinc phthalocyanines (4, 5, 6) are reported for the first time in this study. The resulting compounds were characterized by utilizing some spectroscopic methods, such as UV-Vis, 1HNMR, FT-IR spectroscopy, as well as mass spectraand elemental analysis. To show photosynthesizer's potential, emission (FF), singlet oxygen (1O2), and photodegradation quantum yields (ΦΔ, Φd) of octaperipherally phthalocyanines (Pcs) were performed in the solutions, such as biocompatible solvent DMSO (dimethyl sulfoxide) as well as DMF …
Evaluation Of Carbonic Anhydrase And Paraoxonase Inhibition Activities And Molecular Docking Studies Of Highly Water-Soluble Sulfonated Phthalocyanines, Emre Güzel, Fati̇h Sönmez, Sultan Erkan, Kübra Çikrikci, Adem Ergün, Nahi̇t Gençer, Oktay Arslan, Makbule Koçak
Evaluation Of Carbonic Anhydrase And Paraoxonase Inhibition Activities And Molecular Docking Studies Of Highly Water-Soluble Sulfonated Phthalocyanines, Emre Güzel, Fati̇h Sönmez, Sultan Erkan, Kübra Çikrikci, Adem Ergün, Nahi̇t Gençer, Oktay Arslan, Makbule Koçak
Turkish Journal of Chemistry
The investigation of carbonic anhydrase and paraoxonase enzyme inhibition properties of water-soluble zinc and gallium phthalocyanine complexes (1 and 2) are reported for the first time. The binding of p-sulfonylphenoxy moieties to the phthalocyanine structure favors excellent solubilities in water, as well as providing an inhibition effect on carbonic anhydrase (CA) I and II isoenzymes and paraoxonase (PON1) enzyme. According to biological activity results, both complexes inhibited hCA I, hCA II, and PON1. Whereas 1 and 2 showed moderate hCA I and hCA II (off-target cytosolic isoforms) inhibitory activity (Ki values of 26.09 μM and 43.11 μM for hCA I …
Chemical Composition, And Antibacterial And Antioxidant Activities Of Essential Oils From Laggera Tomentosa Sch. Bip. Ex Oliv. Et Hiern (Asteraceae), Tokuma Getahun, Vinit Sharma, Deepak Kumar, Neeraj Gupta
Chemical Composition, And Antibacterial And Antioxidant Activities Of Essential Oils From Laggera Tomentosa Sch. Bip. Ex Oliv. Et Hiern (Asteraceae), Tokuma Getahun, Vinit Sharma, Deepak Kumar, Neeraj Gupta
Turkish Journal of Chemistry
Laggera tomentosa Sch. Bip. ex Oliv. et Hiern (Asteraceae), an endemic Ethiopian medicinal plant, is traditionally used to treat various ailments. Previously, the chemical constituents of the essential oil (EO) of its leaves and inflorescence were documented. However, no data about the chemical compositions of other parts of the EOs of the plant have been reported to date. Moreover, there are no previous biological activity reports on any parts of the EOs of this plant. Thus, in this study, the EOs were isolated from the stem bark and roots of this plant by hydrodistillation and analyzed using gas chromatography-mass spectrometry …
Innovational Combination Of Hetero-Bifunctional N-Peg Quinoline Scaffolds Derivatives With Improved Anticancer Activity Against Breast And Colon Cancer Cell Lines And P-Glycoprotein, Cytochrome P450 Enzyme Activity Prediction, Mahesh Gaidhane, Ajay Ghatole, Kushal Lanjewar, Kishor Hatzade
Innovational Combination Of Hetero-Bifunctional N-Peg Quinoline Scaffolds Derivatives With Improved Anticancer Activity Against Breast And Colon Cancer Cell Lines And P-Glycoprotein, Cytochrome P450 Enzyme Activity Prediction, Mahesh Gaidhane, Ajay Ghatole, Kushal Lanjewar, Kishor Hatzade
Turkish Journal of Chemistry
Polyethylene glycol (PEG) is a polymer that is widely used as a carrier for drug delivery systems (DDS). A library of N-PEGylated quinoline derivatives of PEG molecular weight 200 was prepared rapidly after the activation of PEGs using maleic anhydride. Quinoline with a polymer backbone is essential as new material. PEG is a water-soluble nonionic polymer approved by food and drug organizations for medicine applications. Because of its nontoxic grapheme, it is widely utilized in numerous biochemical, cosmetic, pharmaceutical, and industrialized applications. The modern SwissADME is a web tool that stretches free admittance to a pool of hasty, yet solid, …
Computational And Biological Studies Of Novel Thiazolyl Coumarin Derivatives Synthesized Through Suzuki Coupling, Shaista Parveen, Saima Kalsoom, Rifhat Bibi, Ambreen Asghar, Abdul Hameed, Waqar Ahmed, Abbas Hassan
Computational And Biological Studies Of Novel Thiazolyl Coumarin Derivatives Synthesized Through Suzuki Coupling, Shaista Parveen, Saima Kalsoom, Rifhat Bibi, Ambreen Asghar, Abdul Hameed, Waqar Ahmed, Abbas Hassan
Turkish Journal of Chemistry
The current investigation presents the synthesis, computational molecular-docking and biological activity studies of arylated thiazole coumarins. Aryl substituted thiazolyl coumarin derivatives were synthesized via Suzuki cross-coupling reaction. A detailed reaction condition optimization revealed that the Pd-PEPPSI-IPent precatalyst in only 2 mol% loading resulted in the desired product with high yield. The aim of this study was to examine the antimicrobial behavior of thiazole coumarin derivatives through in vitro and in silico studies. All the compounds showed activity against both antibacterial strains, Staphylococcus aureus and Escherichia coli, except 5d. Similarly, the compounds 5a, 5b, and 5d were found to be active …
Synthesis And Molecular Docking Studies Of Quinoline Derivatives As Hiv Non-Nucleoside Reverse Transcriptase Inhibitors, Nivedita Bhardwaj, Diksha Choudhary, Akashdeep Pathania, Somesh Baranwal, Pradeep Kumar
Synthesis And Molecular Docking Studies Of Quinoline Derivatives As Hiv Non-Nucleoside Reverse Transcriptase Inhibitors, Nivedita Bhardwaj, Diksha Choudhary, Akashdeep Pathania, Somesh Baranwal, Pradeep Kumar
Turkish Journal of Chemistry
Quinoline moiety is an important scaffold in the field of drug discovery and drug development, with a wide range of pharmacological activities. Quinoline derivatives are potent inhibitors for reverse transcriptase, which is responsible for the conversion of single-stranded viral RNA into double-stranded viral DNA.In the present study, we have designed and synthesized 2 series, namely pyrazoline and pyrimidine containing quinoline derivatives as non nucleoside reverse transcriptase inhibitors (NNRTIs). Eleven compounds were synthesized and characterized by 1H and 13C NMR and mass spectrophotometry. The synthesized compounds were also docked on an HIV reverse transcriptase binding site (PDB: 4I2P); most of these …
Design Of Novel Substituted Phthalocyanines; Synthesis And Fluorescence, Dft,Photovoltaic Properties, Mehmet Sali̇h Ağirtaş, Derya Güngördü Solğun, Ümi̇t Yildiko, Abdullah Özkartal
Design Of Novel Substituted Phthalocyanines; Synthesis And Fluorescence, Dft,Photovoltaic Properties, Mehmet Sali̇h Ağirtaş, Derya Güngördü Solğun, Ümi̇t Yildiko, Abdullah Özkartal
Turkish Journal of Chemistry
The 4-(2-[3,4-dimethoxyphenoxy] phenoxy) phthalonitrile was synthesized as the starting material of new syntheses. Zinc, copper, and cobalt phthalocyanines were achieved by reaction of starting compound with Zn(CH3COO)2, CuCl2, and CoCl2 metal salts. Basic spectroscopic methods such as nuclear magnetic resonance electronic absorption, mass and infrared spectrometry were used in the structural characterization of the compounds. Absorption, excitation, and emission measurements of the fluorescence zinc phthalocyanine compound were also investigated in THF. Then, structural, energy, and electronic properties for synthesized metallophthalocyanines were determined by quantum chemical calculations, including the DFT method. The bandgap of HOMO and LUMO was determined to be …