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The Prevalence Of Seven Crucial Honeybee Viruses Using Multiplex Rt-Pcr And Theirphylogenetic Analysis, Abdurrahman Anil Çağirgan, Zafer Yazici
The Prevalence Of Seven Crucial Honeybee Viruses Using Multiplex Rt-Pcr And Theirphylogenetic Analysis, Abdurrahman Anil Çağirgan, Zafer Yazici
Turkish Journal of Veterinary & Animal Sciences
Honey bee viruses may be of severe adverse effect on bee colonies. Till now, more than twenty honey bee viruses have been identified. The aim of this study was to investigate the prevalence of seven honey bee viruses, namely Israeli acute paralysis virus (IAPV), deformed wing virus (DWV), sacbrood virus (SBV), acute bee paralysis virus (ABPV), black queen cell virus (BQCV), Kashmir bee virus (KBV), and chronic bee paralysis virus (CBPV) using a multiplex reverse transcription polymerase chain reaction (mRT-PCR). A total of 111 apiaries were randomly selected and adult bees and larvae samples were obtained from seemingly healthy colonies …
Carnitine Concentrations In Healthy And Septicaemia Suspected Neonatal Calves And Itsrelation To Passive Immunty, Erhan Gökçe, Mahmut Sözmen, Canan Gülmez, Kadi̇r Bozukluhan, Gürbüz Gökce, Emi̇ne Ataki̇şi̇, Mehmet Çi̇ti̇l, Hi̇dayet Meti̇n Erdoğan
Carnitine Concentrations In Healthy And Septicaemia Suspected Neonatal Calves And Itsrelation To Passive Immunty, Erhan Gökçe, Mahmut Sözmen, Canan Gülmez, Kadi̇r Bozukluhan, Gürbüz Gökce, Emi̇ne Ataki̇şi̇, Mehmet Çi̇ti̇l, Hi̇dayet Meti̇n Erdoğan
Turkish Journal of Veterinary & Animal Sciences
This study was designed to determine carnitine concentrations in newborn calves with suspected septicaemia, healthy calves, and colostrum samples as well as to detect alterations in blood carnitine concentrations after colostrum intake. Carnitine concentrations were detected in both neonatal calves with suspected septicaemia (n = 195) and healthy calves (n =10) as well as in colostrum/milk samples from their dams (n = 20). The mean carnitine concentration on the 2nd day after colostrum intake (32.61 μmol/L) was significantly higher than that measured before colostrum intake (17.61 μmol/L) (P < 0.05). The striking result was significantly lower mean carnitine concentration detected in calves with suspected septicaemia (17.11 μmol/L), compared to healthy calves (24.92 μmol/L) (P < 0.001). Apart from a sudden increase on day 7, no significant alteration was observed in colostrum/milk carnitine concentrations throughout the postpartum period. The results indicated that colostrum contained carnitine, which passed into the bloodstream of the calf by passive colostral transfer, and that a dramatic reduction in blood carnitine concentrations of calves with suspected septicaemia existed. The results might be of help in dealing with septicaemia suspected neonatal calves through both measurement of blood carnitine and, in response, to supplement such cases with carnitine.
The Morphological And Morphometric Characteristics Of Alabadem Pigeons, Evren Erdem, Fatma Tüli̇n Özbaşer, Eser Kemal Gürcan, Mehmet İhsan Soysal
The Morphological And Morphometric Characteristics Of Alabadem Pigeons, Evren Erdem, Fatma Tüli̇n Özbaşer, Eser Kemal Gürcan, Mehmet İhsan Soysal
Turkish Journal of Veterinary & Animal Sciences
This study aimed to determine the morphological and morphometric characteristics of Alabadem pigeons, which are grown as ornamental pigeons in Edirne province, and to determine mutual traits with other indigenous pigeon breeds in Turkey by comparing with previous studies. Body weight (P < 0.001), head length (P < 0.01), head width (P < 0.05), beak length (P < 0.001), and tarsus diameter (P < 0.05) of age group III were higher than those of other age groups; however, the wingspan of age group II was greater than that of other age groups in Alabadem pigeon. Compared to other indigenous genotypes in Turkey, the Alabadem pigeon is a small-sized genotype. Alabadem pigeons were similar to Edremit butterfly pigeons and Thracian tumbler pigeons in terms of crested and blackeyed pigeons. On the other hand, the irregularly shaped mark (almond) on the head in Alabadem pigeons was similar to the wide-long irregular shaped mark on the neck of Edremit butterfly pigeons. Some basic plumage colors (black, yellow, and red) and intermediate colors (chickpea and scarlet) were identical to Alabadem pigeons and Thrace roller pigeons. Since Alabadem pigeons have many mutual characteristics with Edremit butterfly pigeons and Thracian roller pigeons, genetic studies may be recommended to determine the degree of relationship among these breeds.
Effects Of Honeybee (Apis Mellifera) Venom On Redox Balance, Biochemical Andhematological Profile In Diabetic Rats: A Preliminary Study, Bariş Denk, Abdurrahman Fati̇h Fi̇dan
Effects Of Honeybee (Apis Mellifera) Venom On Redox Balance, Biochemical Andhematological Profile In Diabetic Rats: A Preliminary Study, Bariş Denk, Abdurrahman Fati̇h Fi̇dan
Turkish Journal of Veterinary & Animal Sciences
The treatment of diseases with honeybee venom (apitoxin) is a branch of apitherapy, which has yet to find substantial scientific support. In this present study, we used apitoxin to investigate its effects on diabetes mellitus (DM) in rats. The use of apitoxin injection on single-dose streptozotocin (STZ)-treated rat model was selected, and the study took 28 days. Fasting blood glucose (FBG) was measured weekly. Biochemical and hematological parameters, oxidative stress markers, and insulin levels were measured from the blood samples provided on the last day of the study, and the DNA damage marker (8-OHdG) was measured from urine samples. We …
Effects Of Milk Replacer And Whole Milk Feeding On Rumen Development, Expression Ofgenes Related To Volatile Fatty Acid Absorption, And Rumen Bacteria In Calves, Ahmet Ceylan, Ali̇ Çalik, Burcu Eki̇m, Alev Gürol Bayraktaroğlu, Oğuz Çalişici, Doğukan Özen, Pinar Saçakli
Effects Of Milk Replacer And Whole Milk Feeding On Rumen Development, Expression Ofgenes Related To Volatile Fatty Acid Absorption, And Rumen Bacteria In Calves, Ahmet Ceylan, Ali̇ Çalik, Burcu Eki̇m, Alev Gürol Bayraktaroğlu, Oğuz Çalişici, Doğukan Özen, Pinar Saçakli
Turkish Journal of Veterinary & Animal Sciences
This research examined the effects of liquid feeds on calf performance, rumen development, rumen cellulolytic bacteria count, and total bacteria diversity. Twenty Holstein bull calves were allocated to 2 groups either fed with milk replacer (MR) or whole milk. Calves fed milk tended to have higher (P = 0.058) average daily weight gain as compared to calves fed with MR during the entire experimental period. Starter mixture intake was not influenced by either milk or milk replacer feeding. Calves fed with milk had higher (P < 0.001) proliferative cells in the rumen papilla. The expressions of MCT1, MCT4, NHE1, NHE3, ACSS1, AceCS2, and ACSM1 genes, which are related to volatile fatty acid absorption, in the dorsal sac of the rumen were similar for calves fed either MR or whole milk. Fibrobacter succinogenes (P = 0.017) and Ruminococcus flavefaciens (P = 0.037) were significantly higher in the rumen of the milkfed calves. Moreover, denaturing gradient gel electrophoresis (DGGE)-derived dendrograms showed noticeable differences in ruminal microbial population between MR-fed and milk-fed calves. In conclusion, feeding calves with whole milk, which contains better quality protein and nutrients, instead of milk replacers, positively affects rumen development, cellulolytic bacteria numbers and total bacteria diversity.
Quality, Nutritional, And Sensory Attributes Of Naked Neck Chicken Eggs As Influenced Byproduction Systems And Dietary Regimens, Erum Bughio, Jibran Hussain, Athar Mahmud, Anjum Khalique, Ahmed Sultan Jatoi, Shahid Mehmood, Muhammad Usman, Sohail Ahmad
Quality, Nutritional, And Sensory Attributes Of Naked Neck Chicken Eggs As Influenced Byproduction Systems And Dietary Regimens, Erum Bughio, Jibran Hussain, Athar Mahmud, Anjum Khalique, Ahmed Sultan Jatoi, Shahid Mehmood, Muhammad Usman, Sohail Ahmad
Turkish Journal of Veterinary & Animal Sciences
This study evaluated the quality, nutritional, and sensory attributes of Naked Neck chicken eggs when birds were subjected to different housing and nutritional regimens. Birds were maintained in two rearing systems (intensive & free-range) with five dietary treatments based on commercial feed (CF) and kitchen waste (KW), i.e. 100% CF, 75% CF + 25% KW, 50% CF + 50% KW, 25% CF + 75% KW, and 100% KW. A total of 500 eggs, comprised of ten per replicate (50 per treatment) were used. Higher (p ≤ 0.05) shell weight and thickness, shape index, egg volume, yolk index and weight, egg …
Associations Of Snps In Ghr Gene With Growth And Milk Yield Of Anatolian Buffaloes, Meti̇n Erdoğan, Mustafa Tekerli̇, Koray Çeli̇keloğlu, Özlem Hacan, Serdar Koçak, Zehra Bozkurt, Samet Çi̇nkaya, Mustafa Demi̇rtaş
Associations Of Snps In Ghr Gene With Growth And Milk Yield Of Anatolian Buffaloes, Meti̇n Erdoğan, Mustafa Tekerli̇, Koray Çeli̇keloğlu, Özlem Hacan, Serdar Koçak, Zehra Bozkurt, Samet Çi̇nkaya, Mustafa Demi̇rtaş
Turkish Journal of Veterinary & Animal Sciences
This study was carried out to investigate the associations between single nucleotide polymorphisms (SNP) in the growth hormone receptor (GHR) gene and growth and milk yields of Anatolian buffaloes. Growth records of genotyped 3012 Anatolian buffaloes and 467 lactations of 329 cows from them were used. The overall means of weights at birth, six and 12 months of ages and lactation milk yield were 29.377 ± 0.342 kg, 96.15 ± 1.48 kg, 165.54 ± 2.18 kg, and 976.3 ± 39.9 kg, respectively. Three mutations (g.31601787 G > A, g.31601784 G > A, and g.31601783 G > del) in GHR were detected. A least-squares …
Ruminal Kinetics Of Carbohydrates, Gas Production And Bromatology Of Sugarcane Silagewith High Levels Of Sodium Benzoate, Celso Heinzen Junior, Odimári Pricila Prado Calixto, Egon Henrique Horst, Leonardo Trolegi, Fernando Luiz Massaro Junior, Ivone Yurika Mizubuti, Mikael Neumann, Valter Harry Bumbieris Junior
Ruminal Kinetics Of Carbohydrates, Gas Production And Bromatology Of Sugarcane Silagewith High Levels Of Sodium Benzoate, Celso Heinzen Junior, Odimári Pricila Prado Calixto, Egon Henrique Horst, Leonardo Trolegi, Fernando Luiz Massaro Junior, Ivone Yurika Mizubuti, Mikael Neumann, Valter Harry Bumbieris Junior
Turkish Journal of Veterinary & Animal Sciences
The objective of this study was to evaluate the chemical composition, ruminal kinetics, gas production and aerobic stability of sugarcane silage added with increasing levels of sodium benzoate up to 1% of the natural matter. After harvesting, the sugarcane was chopped and placed in experimental polyethylene silos for storage for 30 days. An increasing concentration of sodium benzoate in the silage promoted a linear decrease in the crude protein content, varying from 2.79% to 2.51%. The addition of sodium benzoate reduced the fiber concentration of the silage (P = 0.0015) and increased gas production of the fibrous and nonfibrous carbohydrates …
A New Molecular Approach To The Diagnosis Of Small Ruminant Morbillivirus Withevagreen Based Assay, Mustafa Emi̇n Öz, Emrah Torlak, Oğuzhan Avci, Müge Doğan, Ali̇ Tevfi̇k Uncu
A New Molecular Approach To The Diagnosis Of Small Ruminant Morbillivirus Withevagreen Based Assay, Mustafa Emi̇n Öz, Emrah Torlak, Oğuzhan Avci, Müge Doğan, Ali̇ Tevfi̇k Uncu
Turkish Journal of Veterinary & Animal Sciences
The present work describes a new method that is anticipated to contribute to the global control and eradication strategies of small ruminant morbillivirus (SRMV), which negatively affects sheep and goat breeding in many countries where outbreaks emerge. Described assay was developed to detect SRMV by targeting the fusion glycoprotein gene. In the study, the EvaGreen based real-time RT-PCR method is compared with real-time RT-PCR based on TaqMan probe, which is recommended as the diagnostic test by World Organisation for Animal Health (OIE). Detection limit, normalized fluorescence values, and sensitivity of the methods were evaluated in the analysis. The lowest limit …
Effect Of Different Doses Of Hydrated C$_{60}$ Fullerene Nanoparticles On Ram Semen Duringcool Storage, Şeyma Özer Kaya, İbrahi̇m Hali̇l Güngör, Serap Dayan Ci̇nkara, Tutku Can Acisu, Recep Hakki Koca, Serkan Ali̇ Akarsu, Coşkun Can, Aslihan Çakir, İrfan Yilmaz, Muhammed Sami̇ Halici, Seyfetti̇n Gür, Mustafa Sönmez, Gaffari̇ Türk
Effect Of Different Doses Of Hydrated C$_{60}$ Fullerene Nanoparticles On Ram Semen Duringcool Storage, Şeyma Özer Kaya, İbrahi̇m Hali̇l Güngör, Serap Dayan Ci̇nkara, Tutku Can Acisu, Recep Hakki Koca, Serkan Ali̇ Akarsu, Coşkun Can, Aslihan Çakir, İrfan Yilmaz, Muhammed Sami̇ Halici, Seyfetti̇n Gür, Mustafa Sönmez, Gaffari̇ Türk
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to determine the effect of different doses of hydrated C$_{60}$ fullerene (C$_{60}$HyFn) nanoparticles on ram semen during cool storage at 5 °C. Semen samples were collected from 7 healthy Akkaraman rams by artificial vagina during nonbreeding season (April) 3 times for two weeks (3 replications), and samples having good initial sperm motility (> 70 %) and count (> 2 billion / mL) were pooled and diluted with tris-egg yolk based extender at 37 °C. Then, the diluted semen samples were divided into 15 aliquots control and 14 different C60HyFn groups (25 nM, 50 nM, …
Analysis Of Some Heavy Metals (Cd And Pb) In The Şanlıurfa Province Using Feral Pigeonblood Samples, Özlem Ütme, Füsun Temamoğullari
Analysis Of Some Heavy Metals (Cd And Pb) In The Şanlıurfa Province Using Feral Pigeonblood Samples, Özlem Ütme, Füsun Temamoğullari
Turkish Journal of Veterinary & Animal Sciences
Birds serve as good biomonitors in determining environmental pollution. As for indicators of environmental pollution, we detected blood heavy metal levels in 32 female and 32 male local Feral pigeons in the central districts of Şanlıurfa, located in southeastern Turkey, in one month of each season. The samples were analyzed by coupled plasma-mass spectrometry. Lead (Pb) levels were measured as 233.1 ± 25.7 μg/kg for Haliliye, 101.2 ± 29.7 μg/kg for Karaköprü, 81.3 ± 22.7 μg/kg for Eyyübiye, and 48.1 ± 27.1 μg/ kg for Suruç, whereas cadmium (Cd) levels were measured as 30.6 ± 12.6 μg/kg for Haliliye, 35.7 …
Genetic Parameter Estimates Of Fear, Growth, And Carcass Characteristics In Japanese Quail, Doğan Nari̇nç, Bariş Aybars Genç
Genetic Parameter Estimates Of Fear, Growth, And Carcass Characteristics In Japanese Quail, Doğan Nari̇nç, Bariş Aybars Genç
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to estimate the heritability values of tonic immobility duration, several growth traits, and their genetic relationships with some slaughter traits. Fearfulness reaction was examined using tonic immobility (TI) response at 5 and 6 weeks of age. All birds were slaughtered at 6 weeks of age to measure carcass yield (CY), and percentage of breast (BY), leg (LY), wing (WY), abdominal fat (AFY). Heritability estimates for the TI durations and body weights measured at 5 and 6 weeks of age were 0.16, 0.20, and 0.46, 0.44, respectively. Heritability estimates for growth curve parameters and inflection …
Effects Of Dietary Guar Meal With Or Without Beta-Mannanase On The Egg Yolk Fatty Acids,Cholesterol, And Some Blood Parameters Of Laying Hens, Süleyman Çalişlar
Effects Of Dietary Guar Meal With Or Without Beta-Mannanase On The Egg Yolk Fatty Acids,Cholesterol, And Some Blood Parameters Of Laying Hens, Süleyman Çalişlar
Turkish Journal of Veterinary & Animal Sciences
In this study, the effects of adding enzyme to the diets containing guar meal (GM) on the egg yolk fatty acids, cholesterol, and some blood plasma parameters of hens were examined. This study was carried out in the chicken coop of the Experimental Animals Ethics Committee, Faculty of Agriculture. This study constitutes the second phase of the study titled ?Effects of dietary guar meal with or without beta-mannanase on performance and egg quality traits in laying hens?, previously published. The experimental period lasted 126 days. Ninety-six Lohman Brown hens at the age of 56 weeks were and kept in individual …
Clinicopathological Characteristics And Mutational Profile Of Kras And Nras Intunisian Patients With Sporadic Colorectal Cancer, Donia Ounissi, Marwa Weslati, Rahma Boughriba, Meriam Hazgui, Saadia Bouraoui
Clinicopathological Characteristics And Mutational Profile Of Kras And Nras Intunisian Patients With Sporadic Colorectal Cancer, Donia Ounissi, Marwa Weslati, Rahma Boughriba, Meriam Hazgui, Saadia Bouraoui
Turkish Journal of Medical Sciences
Background/aim: Colorectal cancer (CRC) is a major public health problem worldwide and in Tunisia due to its increasing rate of incidence. KRAS and NRAS mutations have become a pivotal part of CRC diagnosis, given their association to treatment resistance with antiepidermal growth factor receptor (EGFR) monoclonal antibodies. In this study, we aimed to screen for mutations in KRAS and NRAS genes in Tunisian patients with CRC and explore their correlations with clinicopathological features. Materials and methods: AmoyDx KRAS and NRAS mutation real-time PCR kits were used to screen for mutations in KRAS (exon 2) and NRAS (exons 2, 3, and …
Can Urinary Biomarkers Predict Acute Kidney Injury In Newborns With Critical Congenitalheart Disease?, Özgün Uygur, Özge Altun Köroğlu, Reşi̇t Ertürk Levent, Eser Sözmen, Firat Ergi̇n, Yüksel Atay, Mehmet Yalaz, Mete Akisü, Ni̇lgün Kültürsay
Can Urinary Biomarkers Predict Acute Kidney Injury In Newborns With Critical Congenitalheart Disease?, Özgün Uygur, Özge Altun Köroğlu, Reşi̇t Ertürk Levent, Eser Sözmen, Firat Ergi̇n, Yüksel Atay, Mehmet Yalaz, Mete Akisü, Ni̇lgün Kültürsay
Turkish Journal of Medical Sciences
Background/aim: Congenital heart disease (CHD) is the most common congenital malformation group and is the leading cause of newborn mortality in developed countries. Most of the infants with CHD develop preoperative or postoperative acute kidney injury (AKI). Acute kidney injury may develop before the serum creatinine rise and oliguria. Urinary biomarkers such as kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin (IL)-18, and cystatin C may predict AKI in patients with critical CHD (CCHD) before the serum creatinine rise. In this study, we aimed to determine the AKI incidence among newborn patients with CCHD and investigate the predictivity of …
The Evaluation Of Intracellular Energy Metabolism In Prediabetic Patients And Patientsnewly Diagnosed With Type 2 Diabetes Mellitus, Erkan Dulkadi̇roğlu, Hüseyi̇n Özden, Hüseyi̇n Demi̇rci̇
The Evaluation Of Intracellular Energy Metabolism In Prediabetic Patients And Patientsnewly Diagnosed With Type 2 Diabetes Mellitus, Erkan Dulkadi̇roğlu, Hüseyi̇n Özden, Hüseyi̇n Demi̇rci̇
Turkish Journal of Medical Sciences
Background/aim: Increased susceptibility to infections is a serious problem in diabetics. Impairment in the energy metabolism of the immune system is the main source of the problem. Early diagnosis of the impairment in energy metabolism is crucial. Our study aimed to investigate the energy metabolism in leukocytes in patient groups such as prediabetics and patients newly diagnosed with type 2 diabetes mellitus. Materials and methods: Our study included 21 newly diagnosed type 2 diabetic patients (NDDP), 30 prediabetic patients, and 22 adult volunteers. 75 g oral glucose tolerance test (OGTT) was applied to all patients included in the study. Blood …
An Evaluation Of Suspected Cases Of Hantavirus Infection Admitted To A Tertiary Care University Hospital In Düzce, Turkey, Between 2012 And 2018, Nevi̇n İnce, Kürşad Öneç, Tansu Sav, Mehmet Ali̇ Sungur, Di̇lek Menemenli̇oğlu
An Evaluation Of Suspected Cases Of Hantavirus Infection Admitted To A Tertiary Care University Hospital In Düzce, Turkey, Between 2012 And 2018, Nevi̇n İnce, Kürşad Öneç, Tansu Sav, Mehmet Ali̇ Sungur, Di̇lek Menemenli̇oğlu
Turkish Journal of Medical Sciences
Background/aim: Hantavirus is a rodent borne zoonosis caused by the members of the virus family Bunyaviridae, genus Hantavirus. In this study, we aimed to determine the role of peripheral blood leukocyte ratio in differential diagnosis of Hantavirus disease. Materials and methods: The medical records of patients at the Düzce University Medical Faculty were examined retrospectively. A total of 20 patients diagnosed with hantavirus infection confirmed by serologic tests were included in the study (Group 1). The other group consisted of 30 patients suspected of hantavirus infection but found negative (Group 2). Demographic, clinical and laboratory characteristics, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte …
Validation Of The Nosas Score For Screening Sleep-Disordered Breathing: A Sleep Clinicbasedstudy In Turkey, Burcu Oktay Arslan, Zeynep Zeren Uçar, Özgür Batum, Mehmet Nurullah Orman
Validation Of The Nosas Score For Screening Sleep-Disordered Breathing: A Sleep Clinicbasedstudy In Turkey, Burcu Oktay Arslan, Zeynep Zeren Uçar, Özgür Batum, Mehmet Nurullah Orman
Turkish Journal of Medical Sciences
Background/aim: The NoSAS score is a new tool for the identification of high-risk patients for sleep-disordered breathing (SDB). The aim of this study was to validate the NoSAS score in a sleep clinical population in Turkey and compare its performance with the Epworth Sleepiness Scale (ESS), STOP-Bang, and Berlin questionnaires for high-risk SDB. Materials and methods: This was a retrospective study. Patients who had a full-night PSG examination between 01.03.2017 and 01.01.2018 at the sleep center of our hospital were included in the study. Demographic characteristics, anthropometrics measurements, ESS, STOP-Bang, and Berlin scores were collected from the existing data of …
Covid-19 Scientific Publications From Turkey, Rafi̇ye Çi̇ftçi̇ler, İbrahi̇m Celaletti̇n Haznedaroğlu, Abdurrahman Tufan, Mehmet Aki̇f Öztürk
Covid-19 Scientific Publications From Turkey, Rafi̇ye Çi̇ftçi̇ler, İbrahi̇m Celaletti̇n Haznedaroğlu, Abdurrahman Tufan, Mehmet Aki̇f Öztürk
Turkish Journal of Medical Sciences
No abstract provided.
The Role Of Lateralisation And Sex On Insular Cortex: 3d Volumetric Analysis, Fatma Öz, Ni̇yazi̇ Acer, Ni̇han Katayifçi, Güneş Aytaç, Kami̇l Karaali̇, Muzaffer Si̇ndel
The Role Of Lateralisation And Sex On Insular Cortex: 3d Volumetric Analysis, Fatma Öz, Ni̇yazi̇ Acer, Ni̇han Katayifçi, Güneş Aytaç, Kami̇l Karaali̇, Muzaffer Si̇ndel
Turkish Journal of Medical Sciences
Background/aim: The insula has attracted the attention of many neuroimaging studies because of its key role between brain structures. However, the number of studies investigating the effect of sex and laterality on insular volume is insufficient. The aim of this study was to investigate the differences in insular volume between sexes and hemispheres. Materials and methods: A total of 47 healthy participants [24 males (20.08 ± 1.44 years) and 23 females (19.57 ± 0.90 years)] underwent magnetic resonance imaging (MRI). Imaging was performed using the 3T MRI scanner. The insular volume was measured using the Individual Brain Atlases using Statistical …
The Study Of Sirtuins In Breast Cancer Patients Before And After Radiotherapy, Nazli Helvaci, Hati̇ce Saraçoğlu, Oğuz Gali̇p Yildiz, Eser Kiliç
The Study Of Sirtuins In Breast Cancer Patients Before And After Radiotherapy, Nazli Helvaci, Hati̇ce Saraçoğlu, Oğuz Gali̇p Yildiz, Eser Kiliç
Turkish Journal of Medical Sciences
Background/aim: Targeting the new and unique proteins is an important medical strategy for treating breast cancer. It is quite important to find out proteins that have a role in the development of cancer. Sirtuins (SIRT) are well related in different physiological activities and connected with cancer. We aimed to determine the effect of radiotherapy on SIRT1 and SIRT2, which have not been yet been clarified as a tumor suppressor or promoter. Materials and methods: Twenty-two women with nonmetastatic breast cancer enrolled in the study. Blood samples were taken before and after radiotherapy, soluble SIRT1 and SIRT2 levels were determined with …
Can Pre-Procedural Mri Signal Intensity Ratio Predict The Success Of Uterine Arteryembolization In Treatment Of Myomas?, Çağlayan Çakir, Fati̇h Kilinç, Muhammed Aki̇f Deni̇z, Sema Karakaş
Can Pre-Procedural Mri Signal Intensity Ratio Predict The Success Of Uterine Arteryembolization In Treatment Of Myomas?, Çağlayan Çakir, Fati̇h Kilinç, Muhammed Aki̇f Deni̇z, Sema Karakaş
Turkish Journal of Medical Sciences
Background/aim: Magnetic resonance (MR) images, signal intensity ratios calculated using region of interests (ROI) in T2W images by proportioning the dominant myoma to iliac muscle can aid patient selection and, thus, in achieving better outcomes with the uterine artery embolization (UAE) procedure. The present study investigates the association between the success of UAE treatment with signal intensity (SI) ratio of the dominant myoma to the iliac muscle in MR imaging performed prior to the procedure. Materials and methods: This is a retrospective study and included 30 patients who admitted to our clinic between February 2017 and July 2019 due to …
Evaluation Of S100a12 Protein Levels In Children With Familial Mediterranean Fever, Yelda Türkmenoğlu, Eli̇f Güney, Di̇ğdem Bezen, Ahmet İrdem, Bi̇ray Ertürk, Hasan Dursun
Evaluation Of S100a12 Protein Levels In Children With Familial Mediterranean Fever, Yelda Türkmenoğlu, Eli̇f Güney, Di̇ğdem Bezen, Ahmet İrdem, Bi̇ray Ertürk, Hasan Dursun
Turkish Journal of Medical Sciences
Background/aim: Familial Mediterranean fever (FMF), the most common autoinflammatory disease in children, is characterized by recurrent febrile episodes. FMF is known to progress with chronic inflammation, particularly during attack periods. This study aimed to investigate the relationship of S100A12, an inflammatory marker, with attacks and inflammatory events in FMF patients. Materials and methods: The study included 57 patients diagnosed with FMF, 43 in an attack-free period and 14 in an attack period, and 31 healthy children as the control group. Only white blood cell (WBC) count, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and S100A12 level were analyzed in …
The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe
The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe
Turkish Journal of Medical Sciences
Background/aim: To investigate the histopathological effects of reabsorbable polyethylene glycol hydrogel (RPGH, Coseal) on epidural fibrosis (EF) following laminectomy in rats. Materials and methods: A total of 24 rats were equally divided into three groups. In the first group, no treatment was applied after laminectomy (control group, Group 1). In the second group, hemostasis was achieved after laminectomy, and 2 mm absorbable gelatin sponge soaked in saline was placed over the epidural space and the wound was closed (Group 2). In the third group, hemostasis was achieved following laminectomy, and 0.5 mL RPGH (Coseal, Group 3) was squeezed over the …
Investigation Of The Effect Of Hyperthyroidism On Endoplasmic Reticulum Stress And Transient Receptor Potential Canonical 1 Channel In The Kidney, Nuri̇ye Ezgi̇ Bektur, Erhan Şahi̇n, Sedat Kaçar, Ridvan Bağci, Şeri̇fe Karakaya, Di̇lek Burukoğlu Dönmez, Varol Şahi̇ntürk
Investigation Of The Effect Of Hyperthyroidism On Endoplasmic Reticulum Stress And Transient Receptor Potential Canonical 1 Channel In The Kidney, Nuri̇ye Ezgi̇ Bektur, Erhan Şahi̇n, Sedat Kaçar, Ridvan Bağci, Şeri̇fe Karakaya, Di̇lek Burukoğlu Dönmez, Varol Şahi̇ntürk
Turkish Journal of Medical Sciences
Background/aim: Hyperthyroidism is associated with results in increased glomerular filtration rate as well as increased renin-angiotensin-aldosterone activation. The disturbance of Ca2+ homeostasis in the endoplasmic reticulum (ER) is associated with many diseases, including diabetic nephropathy and hyperthyroidism. Transient receptor potential canonical 1 (TRPC1) channel is the first cloned TRPC family protein. Although it is expressed in many places in the kidney, its function is uncertain. TRPC1 is involved in regulating Ca2+ homeostasis, and its upregulation increases ER Ca2+ level, activates the unfolded protein response, which leads to cellular damage in the kidney. This study investigated the role of TRPC1 in …
Contribution Of Amniotic Membrane To The Healing Of Iatrogenic Vas Deferens Injury, Sabri̇ Demi̇r, Ahmet Ertürk, Mehmet Zengi̇n, Di̇nçer Yildiz, Si̇yami̇ Karahan, Emrah Şenel
Contribution Of Amniotic Membrane To The Healing Of Iatrogenic Vas Deferens Injury, Sabri̇ Demi̇r, Ahmet Ertürk, Mehmet Zengi̇n, Di̇nçer Yildiz, Si̇yami̇ Karahan, Emrah Şenel
Turkish Journal of Medical Sciences
Background/aim: Iatrogenic vas deferens injury is one of the most serious complications of operations in the inguinal region. Vasovasostomy is performed as treatment. However, stenosis is common after vasovasostomy. Oligospermia or azoospermia may develop and result in infertility. This study aimed to investigate the effect of amniotic membrane on healing in vas deferens injuries. Materials and methods: Four groups consisting of 10 rats each were formed. No procedure was performed in Group-I. In GroupII, the left vas deferens was transected and left to spontaneous healing. In Group-III, the left vas deferens was transected, and endto-end anastomosis was performed. In Group-IV, …
Phenotypic Characterization Of Familial Mediterranean Fever Patients Harboring Variantsof Uncertain Significance, Alper Sari, Erdal Bodakçi̇, Berkan Armağan, Hasan Satiş, Nuh Ataş, Nazi̇fe Şule Yaşar Bi̇lge, Reyhan Bi̇li̇ci̇ Salman, Gözde Kübra Yardimci, Hakan Babaoğlu, Levent Kiliç, Mehmet Aki̇f Öztürk, Şemi̇nur Haznedaroğlu, Berna Göker, Umut Kalyoncu, Ti̇muçi̇n Kaşi̇foğlu
Phenotypic Characterization Of Familial Mediterranean Fever Patients Harboring Variantsof Uncertain Significance, Alper Sari, Erdal Bodakçi̇, Berkan Armağan, Hasan Satiş, Nuh Ataş, Nazi̇fe Şule Yaşar Bi̇lge, Reyhan Bi̇li̇ci̇ Salman, Gözde Kübra Yardimci, Hakan Babaoğlu, Levent Kiliç, Mehmet Aki̇f Öztürk, Şemi̇nur Haznedaroğlu, Berna Göker, Umut Kalyoncu, Ti̇muçi̇n Kaşi̇foğlu
Turkish Journal of Medical Sciences
Background/aim: Familial Mediterranean Fever (FMF) is the prototype of hereditary autoinflammatory disorders and caused by mutations on the MEFV gene located on the short arm of chromosome 16. Although some MEFV variants are clearly associated with disease phenotype, there are numerous variants with unknown clinical association which are termed as variants of uncertain significance (VUS). Here, we present clinical correlations of VUS in a large cohort of adult FMF patients from three tertiary centers located in Central Anatolia. Materials and methods: All patients were recruited from FMF in Central Anatolia (FiCA) cohort. Demographic (sex, age at disease onset) and clinical …
Mefv Mutation Frequencies In A Turkish Cohort With Low Prevalence Of Familialmediterranean Fever, Necati̇ Çakir, Hülya Azakli, Duran Üstek, Ömer Uysal, Eren Gözke
Mefv Mutation Frequencies In A Turkish Cohort With Low Prevalence Of Familialmediterranean Fever, Necati̇ Çakir, Hülya Azakli, Duran Üstek, Ömer Uysal, Eren Gözke
Turkish Journal of Medical Sciences
Background/aim: Familial Mediterranean fever (FMF) is a genetically recessive autoinflammatory disease caused by mutations in the Mediterranean fever (MEFV) gene. The aim of this study was to investigate the frequencies of the most common MEFV mutations among a sample of healthy individuals from the Havsa population of European Turkey, where FMF is less prevalent compared to Asian Turkey. Materials and methods: The study group consisted of 263 unrelated healthy adults. All of the participants were analyzed for the M694V, V726A, M680I, and E148Q mutations in the MEFV gene. Results: In total, 25 of the 263 individuals carried MEFV mutations (9.5%). …
Folfirinox Versus Gemcitabine-Cisplatin Combination As First-Line Therapy Intreatment Of Pancreaticobiliary Cancer, Nesli̇han Kayahan Satiş, Mustafa Karaca, Hasan Satiş, Di̇lek Yapar, Ahmet Özet
Folfirinox Versus Gemcitabine-Cisplatin Combination As First-Line Therapy Intreatment Of Pancreaticobiliary Cancer, Nesli̇han Kayahan Satiş, Mustafa Karaca, Hasan Satiş, Di̇lek Yapar, Ahmet Özet
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to compare efficacy and safety of a combination chemotherapy regimen consisting of oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) and gemcitabine-cisplatin as first-line therapy in patients with pancreatic cancer. Materials and methods: Pancreaticobiliary cancer patients who had Eastern Cooperative Oncology Group performance status score of 0 or 1 (on a scale of 0 to 5, with higher scores indicating greater severity of illness) were evaluated to receive folfirinox or gemcitabine plus cisplatin. The primary endpoints were progression-free and overall survival time. Safety analysis was also evaluated as secondary measures. Results: There were 32 patients …
A New Approach To Predicting Shoulder Dystocia: Fetal Clavicle Measurement, Eli̇f Terzi̇
A New Approach To Predicting Shoulder Dystocia: Fetal Clavicle Measurement, Eli̇f Terzi̇
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the relationship between second- and third-trimester clavicle lengths and birth weight and shoulder dystocia. Materials and methods: This prospective observational study included 181 patients who presented to the Private Etlik Lokman Hekim Hospital for routine pregnancy visits between March 2019 and March 2020. In addition to routine pregnancy examinations, the patients also underwent ultrasonography twice at weeks 20-23 and 33-36 to determine the length of the fetal clavicle. The patients were evaluated for shoulder dystocia in the second stage of labor. The birth weight of the neonates was recorded. The primary objective of this …