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Supercritical Carbon Dioxide Extraction Of Usnea Longissima (L.) Ach.: Optimization By Box-Behnken Design (Bbd), Ceren Ati̇la Di̇nçer, Ceren Gökalp, Bengü Geti̇ren, Ati̇la Yildiz, Nuray Yildiz
Supercritical Carbon Dioxide Extraction Of Usnea Longissima (L.) Ach.: Optimization By Box-Behnken Design (Bbd), Ceren Ati̇la Di̇nçer, Ceren Gökalp, Bengü Geti̇ren, Ati̇la Yildiz, Nuray Yildiz
Turkish Journal of Chemistry
Usnic acid (UA) was extracted from Usnea longissima (L.) Ach. in supercritical carbon dioxide (SC-CO2) medium. The selected process parameters were extraction temperature (35-45 °C), amount of co-solvent (0%-5%) and extraction time (5-9 h). These parameters were applied to Box-Behnken design (BBD) belonging to response surface methodology (RSM) to determine optimum process parameters for the highest amount of UA in the extract. g UA/100g lichen, extraction yield % and UA content values were calculated in the range of 0.045-0.317, 2.77-5.4 and 71%-82% in different experimental conditions, respectively. The optimum conditions were predicted as 42 °C, 4.3% (ethanol) and 7.48 h. …
Gc-Ms Analyses And Bioactivities Of Essential Oil Obtained From The Roots Ofchrysopogon Zizanioides (L.) Roberty Cultivated In Giresun, Turkey, Derya Efe, Mustafa Karaköse, Ayça Aktaş Karaçeli̇k, Bengü Ertan, Mehmet Emi̇n Şeker
Gc-Ms Analyses And Bioactivities Of Essential Oil Obtained From The Roots Ofchrysopogon Zizanioides (L.) Roberty Cultivated In Giresun, Turkey, Derya Efe, Mustafa Karaköse, Ayça Aktaş Karaçeli̇k, Bengü Ertan, Mehmet Emi̇n Şeker
Turkish Journal of Chemistry
The essential oils (EOs) constituents have trade importance due to their bioactivities. In this research, the essential oil of the roots of Chrysopogon zizanioides (L.) Roberty cultivated in Giresun was obtained by hydrodistillation. Then, the chemical composition and biological activities of Chrysopogon zizanioides root essential oil (CEO) were studied. Thirty compounds were identified by gas chromatography-mass spectrometry (GC-MS) and the major compounds were determined as isobutyl-angelate (11.15%), α-muurolene (10.56%), α-cedrene (8.42%), α-patchoulene (8.10%), and ethylene brassylate (7.49%). The antimicrobial effect of CEO was investigated against pathogenic bacteria and fungus. Minimal inhibition concentration (MIC) was determined 31.25 μg/mL against C. albicans …
Investigation Of Pzt-5h And Pzt-8 Type Piezoelectric Effect On Cycling Stability On Si-Mwcnt Containing Anode Materials, Mehbare Doğrusöz, Muhammed Taha Demi̇rkan, Rezan Demi̇r Çakan
Investigation Of Pzt-5h And Pzt-8 Type Piezoelectric Effect On Cycling Stability On Si-Mwcnt Containing Anode Materials, Mehbare Doğrusöz, Muhammed Taha Demi̇rkan, Rezan Demi̇r Çakan
Turkish Journal of Chemistry
Silicon (Si) containing materials cannot be used in commercial lithium ion batteries due to the mechanical stress problem triggered by volume expansion during cycling. The high-volume change causes mechanical instability of Si anode materials during charging/discharging, resulting fast capacity fading. It is thought that piezoelectric materials can be a solution for the volume expansion problem because of their ability to generate electric field when pressure is applied on them. For this purpose, PZT-8 and PZT-5H type piezoelectric materials were mixed with silicon and multiwalled carbon nanotube (MWCNT) to obtain anode composites and tested electrochemically versus lithium metal. The piezoelectiric effect …
Effect Of Current Density On The Microstructure And Morphology Of The Electrodepositednickel Coatings, Amel Boukhouiete, Saliha Boumendjel, Nour-El-Houda Sobhi
Effect Of Current Density On The Microstructure And Morphology Of The Electrodepositednickel Coatings, Amel Boukhouiete, Saliha Boumendjel, Nour-El-Houda Sobhi
Turkish Journal of Chemistry
The aim of this research work was to study the effect of deposition current density on microstructure and surface morphology of electrodeposited nickel coatings. For this purpose, nickel deposits have been synthesized by direct current from Watts bath without additive, to limit the incorporation of pollutants resulting from surface adsorption or electro-activity of these compounds. Nickel deposits have been investigated by scanning electron microscopy and X-ray diffraction. Cyclic voltammetry was also used to gain information on the general behavior of the deposition. The optimum conditions of deposition were established and the influence of current density on the grain size, surface …
Cytotoxic And Apoptotic Effects Of Hypericum Androsaemum On Prostate Adenocarcinoma(Pc-3) And Hepatocellular Carcinoma (Hep G2) Cell Lines With Identification Of Secondarymetabolites By Lc-Hrms, Nurdan Yazici Bektaş, Ezgi̇ Ersoy, Mehmet Boğa, Tuğçe Boran, Ercan Çinar, Gül Özhan, Ahmet Ceyhan Gören, Esra Eroğlu Özkan
Cytotoxic And Apoptotic Effects Of Hypericum Androsaemum On Prostate Adenocarcinoma(Pc-3) And Hepatocellular Carcinoma (Hep G2) Cell Lines With Identification Of Secondarymetabolites By Lc-Hrms, Nurdan Yazici Bektaş, Ezgi̇ Ersoy, Mehmet Boğa, Tuğçe Boran, Ercan Çinar, Gül Özhan, Ahmet Ceyhan Gören, Esra Eroğlu Özkan
Turkish Journal of Chemistry
The study aims to determine the secondary metabolites of Hypericum androsaemum L. extracts by liquid chromatographyhigh resolution mass spectrometry (LC-HRMS), and investigate the antioxidant and cytotoxic activities of the plant. Cytotoxic activity was evaluated by MTT assay, and apoptosis induction abilities on human prostate adenocarcinoma (PC-3), and hepatocellular carcinoma (Hep G2) cell lines. Accordingly, major secondary metabolites were found as hederagenin (762 ± 70.10 μg/g) in the leaves dichloromethane (LD), herniarin (167 ± 1.50 μg/g) in fruit dichloromethane (FD), (-)-epicatechin (6538 ± 235.36 μg/g) in the leaves methanol (LM), (-)-epigallocatechin gallate (758 ± 20.46 μg/g) in the fruit methanol (FM), …
Study On Potential Applications And Toxicity Analysis Of Green Synthesized Nanoparticles, Rajni Garg, Priya Rani, Rishav Garg, Nnabuk Okon Eddy
Study On Potential Applications And Toxicity Analysis Of Green Synthesized Nanoparticles, Rajni Garg, Priya Rani, Rishav Garg, Nnabuk Okon Eddy
Turkish Journal of Chemistry
Nanomaterials have garnered the significant interest of scientists owing to their technological as well as medical applications. In particular, metal and metal oxide nanoparticles have gained prominence because of their enhanced performance as compared to their bulk counterparts. Metal-supported nanomaterials are anticipated to make major contributions to solving today's most challenging issues, like energy harvesting and environmental remediation. The incorporation of nanoparticles into sensors has significantly enhanced their precision and selectivity. With the advent of green chemistry, green synthetic techniques have been prioritized for the synthesis of single and multicomponent nanomaterials. In the current review, we have addressed the multidimensional …
Cyclodextrin-Active Natural Compounds In Food Applications: A Review Of Antibacterial, Bingren Tian, Yumei Liu
Cyclodextrin-Active Natural Compounds In Food Applications: A Review Of Antibacterial, Bingren Tian, Yumei Liu
Turkish Journal of Chemistry
Many natural compounds have excellent activity against different bacteria. However, their food use to inhibit the bacteria is often limited by poor water solubility, or instability to light, heat, oxygen, and other environmental factors. Cyclodextrin combines with these natural compounds could not only overcome these shortcomings, but also increase the antibacterial ability of active compounds. This review focuses on the following aspects of active natural compounds in cyclodextrin-based food: the preparation, food applications, and their possible antibacterial mechanisms of different systems. Both cyclodextrin and its derivatives are able to selectively combine with different guest molecules, such as terpenes, phenols and …
Antiinflammatory Photodynamic Therapy Potential Of Polyoxyethylene-Substituted Perylene Diimide, Nitrocatechol, And Azo Dye, Özgül Hakli, Kasim Ocakoğlu, Furkan Ayaz
Antiinflammatory Photodynamic Therapy Potential Of Polyoxyethylene-Substituted Perylene Diimide, Nitrocatechol, And Azo Dye, Özgül Hakli, Kasim Ocakoğlu, Furkan Ayaz
Turkish Journal of Chemistry
Photodynamic therapy (PDT) applications enable light-controlled activation of drug candidates instead of their constitutive activities to prevent undesired side effects associated with their constant activities. A specific wavelength of light is utilized to enable electron mobility in the chemical structure, which results in differential activities that may alter cell viability and cellular functions. Canonical photodynamic therapy applications mostly focus on cytotoxicity-based antimicrobial and anticancer properties of the PDT agents. In this study, we focused on subtoxic concentrations of three different molecules containing polyoxyethylene group and examined their antiinflammatory activities on stimulated mammalian macrophages. Stimulated macrophages produce proinflammatory cytokines TNF and …
Microwave Irradiated Synthesis Of Schiff Bases Of 4-(Arylideneamino)-5-Alkyl-2,4-Dihydro-1,2,4-Triazole-3-Thione Containing 1,2,4-Triazole Segment, Mahdi Shirmohammadi, Saeid Souzangarzadeh, Dadkhoda Ghazanfari, Mohsen Ghodratbeigi, Mohammad Reza Akhgar
Microwave Irradiated Synthesis Of Schiff Bases Of 4-(Arylideneamino)-5-Alkyl-2,4-Dihydro-1,2,4-Triazole-3-Thione Containing 1,2,4-Triazole Segment, Mahdi Shirmohammadi, Saeid Souzangarzadeh, Dadkhoda Ghazanfari, Mohsen Ghodratbeigi, Mohammad Reza Akhgar
Turkish Journal of Chemistry
Novel compounds based on the 1,2,4-triazole skeleton were synthesized. A class of 4-amino-5-alkyl-4H-1,2,4-triazole-3- thione created by reaction of thiocarbohydrazide with long-chain aliphatic carboxylic acids, and then the Schiff bases were obtained in the media of heat and microwave waves, in the presence and the absence of a catalyst. Their chemical structures were assayed by elemental analysis, also device spectroscopic methods.
The Removal Of Chromium (Vi) From Tannery Waste Using Spirulina Sp. Immobilized Silica Gel, Nais Pinta Adetya, Uma Fadzilia Arifin, Emiliana Anggriyani
The Removal Of Chromium (Vi) From Tannery Waste Using Spirulina Sp. Immobilized Silica Gel, Nais Pinta Adetya, Uma Fadzilia Arifin, Emiliana Anggriyani
Turkish Journal of Chemistry
The use of microalgae biomass is an alternative solution to the problem of environmental pollution due to heavy metals, one of which is Cr metal in leather tanning liquid waste. However, the ability of biomass to adsorb heavy metals has limitations. Therefore, the algal biomass is immobilized with silica gel in order to obtain a stable structure. This research aims to study the absorption efficiency of Cr (VI) metal by the biomass of Spirulina sp. which is immobilized with silica gel from the tannery liquid waste. The preparation stages in this study were adsorbent preparation, immobilization of biomass with silica …
Synthesis, Characterization, Cox1/2 Inhibition And Molecular Modeling Studies On Novel 2-Thio-Diarylimidazoles, Zafer Şahi̇n, Meli̇ke Kalkan, Barkin Berk, Leyla Yurttaş, Ceysu Bender, Sevde Nur Bi̇lteki̇n Kaleli̇, Şeref Demi̇rayak
Synthesis, Characterization, Cox1/2 Inhibition And Molecular Modeling Studies On Novel 2-Thio-Diarylimidazoles, Zafer Şahi̇n, Meli̇ke Kalkan, Barkin Berk, Leyla Yurttaş, Ceysu Bender, Sevde Nur Bi̇lteki̇n Kaleli̇, Şeref Demi̇rayak
Turkish Journal of Chemistry
Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements and modifications. It is also known that thiazole derivatives have different pharmacological activities. In this study, nine novel 2-[(1,5-diphenyl-1H-imidazole-2-yl)thio]-N-(thiazole-2-yl)acetamide derivatives (Compound 1-9) were synthesized via the reaction of 1,5-disubstitued phenyl-imidazole-2-thiole and N-thiazole acetamide. The inhibitory effects of COX-1 and COX-2 enzymes were tested for the synthesized compounds. Enzyme-ligand interactions of the most active compound on COX subtypes were elucidated by molecular modeling studies. The percent inhibitory effect for compound 1, which is the naked derivative among all the compounds, was …
A Facile Approach For The Synthesis Of Porous Hematite And Magnetite Nanoparticles Through Sol-Gel Self-Combustion, Imene Gritli, Afrah Bardaoui, Jamila Ben Naceur, Salah Ammar, Mohammad Abu Haija, Sherif Mohamed Abdel Salam Keshk, Radhouane Chtourou
A Facile Approach For The Synthesis Of Porous Hematite And Magnetite Nanoparticles Through Sol-Gel Self-Combustion, Imene Gritli, Afrah Bardaoui, Jamila Ben Naceur, Salah Ammar, Mohammad Abu Haija, Sherif Mohamed Abdel Salam Keshk, Radhouane Chtourou
Turkish Journal of Chemistry
Porous magnetite (Fe3O4) and hematite (α-Fe2O3) nanoparticles were prepared via the sol-gel auto-combustion method. The gels were prepared by reacting ferric nitrates (as oxidants) with starch (as fuel) at an elevated temperature of 200 °C. Different ratios (Φ) of ferric nitrates to starch were used for the synthesis (Φ = fuel/oxidant). The synthesized iron oxides were characterized by Fourier transform infrared (FT-IR) spectroscopy, Raman spectroscopy, X-ray diffraction (XRD) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmet-Teller (BET) and vibrating sample magnetometer (VSM) analysis techniques. The crystal structure, morphology, and specific surface area of the iron oxide nanoparticles (Fe3O4 …
Silk Fiber-Based Composite Nanofiber Tissue Scaffold Produced With Electrospinning Method, Meti̇n Yüksek, Mehmet Akalin, Erhan Sancak, Erkan İşgören, Onur Atak, Derya Saltik Çi̇rki̇n, Ali̇ Beyi̇t
Silk Fiber-Based Composite Nanofiber Tissue Scaffold Produced With Electrospinning Method, Meti̇n Yüksek, Mehmet Akalin, Erhan Sancak, Erkan İşgören, Onur Atak, Derya Saltik Çi̇rki̇n, Ali̇ Beyi̇t
Turkish Journal of Chemistry
Wound dressings are one of the most rapidly expanding areas in medical textiles. In recent years, a large number of functional wound dressing has been developed. The aims of these products are to speed up the wound healing process and to provide maximum comfort for patients. Today, the multidisciplinary studies are required to improve further existed wound dressings. The results of such research studies are also promised new hopes for the Turkish textile industry weakened by the global competition. For this purpose, three different polymers were selected as silk fibroin (SF) / polycaprolactone (PCL) / polyethylene oxide (PEO). The productions …
Tunable Aryl Alkyl Pyrazolium Tetrafluoroborate Ionic Liquids/Salts: Synthesis,Characterization, And Applications For Removal Of Methyl Orange From Aqueous Solution, Melek Canbulat Özdemi̇r
Tunable Aryl Alkyl Pyrazolium Tetrafluoroborate Ionic Liquids/Salts: Synthesis,Characterization, And Applications For Removal Of Methyl Orange From Aqueous Solution, Melek Canbulat Özdemi̇r
Turkish Journal of Chemistry
In this work, new tunable aryl alkyl pyrazolium tetrafluoroborate ionic liquids/salts, 2-ethyl-1-(p-X-phenyl)-3,5- dimethylpyrazolium tetrafluoroborate [X: -Br (4a), -OCH3 (4b), -NO2 (4c)] and 2-butyl-1-(p-X-phenyl)-3,5-dimethylpyrazolium tetrafluoroborate [X: -Br (5a), -OCH3 (5b), -NO2 (5c)], were synthesized by following halide-free synthetic route. Their chemical structures were identified through NMR (1H, 13C, 19F), IR, elemental analysis, and HRMS data. The synthesized 4a-4c and 5a-5c salts were used for the removal studies of methyl orange dye from aqueous solutions. The effects of specific parameters such as nature of the solvent, pH, contact time, amount and structure of the salts, and concentration of potassium chloride on the …
Cellular Iron Storage And Trafficking Are Affected By Gtn Stimulation In Primary Glial And Meningeal Cell Culture, Lati̇fe Arzu Aral, Mehmet Ali̇ Ergün, Hayrunni̇sa Bolay Belen
Cellular Iron Storage And Trafficking Are Affected By Gtn Stimulation In Primary Glial And Meningeal Cell Culture, Lati̇fe Arzu Aral, Mehmet Ali̇ Ergün, Hayrunni̇sa Bolay Belen
Turkish Journal of Biology
A well-balanced intracellular iron trafficking in glial cells plays a role in homeostatic processes. Elevated intracellular iron triggers oxidative stress and cell damage in many neurological disorders, including migraine. This study aimed to investigate the effects of glyceryl trinitrate (GTN), on cellular iron homeostasis, matrixmetalloproteinase (MMP)-9, and calcitonin gene related peptide (CGRP) receptor (CRLR/CGRPR1) production in microglia, astrocyte, and meningeal cell cultures. Primary glial and meningeal cells in culture were exposed to GTN for 24 h. Messenger RNA expression was assessed using qPCR. Iron accumulation was visualized via modified Perl?s histochemistry. MMP-9 levels in cell culture supernatants were measured using …
Expression Profiles Of Interferon-Related Genes In Cells Infected With Influenza A Viruses Or Transiently Transfected With Plasmids Encoding Viral Rna Polymerase, Eli̇f Çağlayan, Kadi̇r Turan
Expression Profiles Of Interferon-Related Genes In Cells Infected With Influenza A Viruses Or Transiently Transfected With Plasmids Encoding Viral Rna Polymerase, Eli̇f Çağlayan, Kadi̇r Turan
Turkish Journal of Biology
Influenza A viruses frequently change their genetic characteristics, which leads to the emergence of new viruses. Consequently, elucidation of the relationship between influenza A virus and host cells has a great importance to cope with viral infections. In this study, it was aimed to determine expression profiles of interferon response genes in human embryonic kidney 293 (HEK293) cells infected with human (A/WSN-H1N1) and avian influenza A viruses (duck/Pennsylvania/10218/84/H5N2) or transfected with plasmids encoding viral RdRP subunits and, to obtain clues about the genes that may be important for the viral pathogenesis. The HEK293 cells cultured in a 12-well plate were …
Current Mutatome Of Sars-Cov-2 In Turkey Reveals Mutations Of Interest, Doğa Eski̇er, Evren Akalp, Özlem Dalan, Gökhan Karakülah, Yavuz Oktay
Current Mutatome Of Sars-Cov-2 In Turkey Reveals Mutations Of Interest, Doğa Eski̇er, Evren Akalp, Özlem Dalan, Gökhan Karakülah, Yavuz Oktay
Turkish Journal of Biology
As the underlying pathogen for the COVID-19 pandemic that has affected tens of millions of lives worldwide, SARS-CoV-2 and its mutations are among the most urgent research topics worldwide. Mutations in the virus genome can complicate attempts at accurate testing or developing a working treatment for the disease. Furthermore, because the virus uses its own proteins to replicate its genome, rather than host proteins, mutations in the replication proteins can have cascading effects on the mutation load of the virus genome. Due to the global, rapidly developing nature of the COVID-19 pandemic, local demographics of the virus can be difficult …
Prediction Of Host-Pathogen Protein Interactions By Extended Network Model, İrfan Kösesoy, Murat Gök, Tamer Kahveci̇
Prediction Of Host-Pathogen Protein Interactions By Extended Network Model, İrfan Kösesoy, Murat Gök, Tamer Kahveci̇
Turkish Journal of Biology
Knowledge of the pathogen-host interactions between the species is essentialin order to develop a solution strategy against infectious diseases. In vitro methods take extended periods of time to detect interactions and provide very few of the possible interaction pairs. Hence, modelling interactions between proteins has necessitated the development of computational methods. The main scope of this paper is integrating the known protein interactions between thehost and pathogen organisms to improve the prediction success rate of unknown pathogen-host interactions. Thus, the truepositive rate of the predictions was expected to increase.In order to perform this study extensively, encoding methods and learning algorithms …
Transcriptome Profiles Associated With Selenium-Deficiency-Dependent Oxidative Stress Identify Potential Diagnostic And Therapeutic Targets In Liver Cancer Cells, Damla Gözen, Deni̇z Cansen Kahraman, Kübra Narci, Huma Shehwana, Özlen Konu, Rengül Çeti̇n Atalay
Transcriptome Profiles Associated With Selenium-Deficiency-Dependent Oxidative Stress Identify Potential Diagnostic And Therapeutic Targets In Liver Cancer Cells, Damla Gözen, Deni̇z Cansen Kahraman, Kübra Narci, Huma Shehwana, Özlen Konu, Rengül Çeti̇n Atalay
Turkish Journal of Biology
Hepatocellular carcinoma (HCC) is one of the most common cancer types with high mortality rates and displays increased resistance to various stress conditions such as oxidative stress. Conventional therapies have low efficacies due to resistance and off-target effects in HCC. Here we aimed to analyze oxidative stress-related gene expression profiles of HCC cells and identify genes that could be crucial for novel diagnostic and therapeutic strategies. To identify important genes that cause resistance to reactive oxygen species (ROS), a model of oxidative stress upon selenium (Se) deficiency was utilized. The results of transcriptome-wide gene expression data were analyzed in which …
Arid4b Physically Interacts With Tfap2c In Mouse Embryonic Stem Cells, Ezgi̇ Gül Keski̇n, Jialiang Huang, Ni̇hal Terzi̇ Çi̇zmeci̇oğlu
Arid4b Physically Interacts With Tfap2c In Mouse Embryonic Stem Cells, Ezgi̇ Gül Keski̇n, Jialiang Huang, Ni̇hal Terzi̇ Çi̇zmeci̇oğlu
Turkish Journal of Biology
Precise regulation of gene expression is required for embryonic stem cell (ESC) differentiation. Transcription factor (TF) networks coordinate the balance of pluripotency and differentiation in response to extracellular and intracellular signals. Chromatin factors work alongside TFs to achieve timely regulation of gene expression for differentiation process. Our previous studies showed that a member of the Sin3a corepressor complex, Arid4b, is critical for proper mouse ESC differentiation into mesoderm and endoderm. We found elevated histone 3 lysine 27 acetylation (H3K27Ac) in a subset of genomic loci in meso/endoderm directed arid4b? cells, coincident with their derepression. We reasoned that Sin3a complex may …
Helicobacter-Stimulated Il-10-Producing B Cells Suppress Differentiation Of Lipopolysaccharide/Helicobacter Felis-Activated Stimulatory Dendritic Cells, Doğuş Altunöz, Ayça Sayi Yazgan
Helicobacter-Stimulated Il-10-Producing B Cells Suppress Differentiation Of Lipopolysaccharide/Helicobacter Felis-Activated Stimulatory Dendritic Cells, Doğuş Altunöz, Ayça Sayi Yazgan
Turkish Journal of Biology
Regulatory B cells (Bregs) produce antiinflammatory cytokines and inhibits proinflammatory response. Recently, immunosuppressive roles of Bregs in the effector functions of dendritic cells (DCs) were demonstrated. However, cross talk between Bregs and DCs in Helicobacter infection remains unknown. Here, we showed that direct stimulation of bone marrow-derived DCs (BMDCs) with Helicobacter felis (H. felis) antigen upregulates their CD86 surface expression and causes the production of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-12 (IL-12), and interleukin-10 (IL-10). Furthermore, prestimulation of DCs with supernatants derived from both Helicobacter-stimulated IL-10- B (Hfstim-IL-10- B) or IL-10+ B (Hfstim-IL-10+) cells suppresses the secretion of …
Crosstalk Between Autophagy And Dna Repair Systems, Si̇nem Sarikaya, Hati̇ce Çakir, Devri̇m Gözüaçik, Yunus Akkoç
Crosstalk Between Autophagy And Dna Repair Systems, Si̇nem Sarikaya, Hati̇ce Çakir, Devri̇m Gözüaçik, Yunus Akkoç
Turkish Journal of Biology
Autophagy and DNA repair are two essential biological mechanisms that maintain cellular homeostasis. Impairment of these mechanisms was associated with several pathologies such as premature aging, neurodegenerative diseases, and cancer. Intrinsic or extrinsic stress stimuli (e.g., reactive oxygen species or ionizing radiation) cause DNA damage. As a biological stress response, autophagy is activated following insults that threaten DNA integrity. Hence, in collaboration with DNA damage repair and response mechanisms, autophagy contributes to the maintenance of genomic stability and integrity. Yet, connections and interactions between these two systems are not fully understood. In this review article, current status of the associations …
Identification Of Differentially Expressed Micrornas In Primary Esophageal Achalasia By Next-Generation Sequencing, Mahin Gholipour, Javad Mikaeli, Seyed Javad Mowla, Mohammad Reza Bakhtiarzadeh, Marie Saghaeian Jazi, Naeme Javid, Narges Fazlollahi, Masoud Khoshnia, Naser Behnampour, Abdolvahab Moradi
Identification Of Differentially Expressed Micrornas In Primary Esophageal Achalasia By Next-Generation Sequencing, Mahin Gholipour, Javad Mikaeli, Seyed Javad Mowla, Mohammad Reza Bakhtiarzadeh, Marie Saghaeian Jazi, Naeme Javid, Narges Fazlollahi, Masoud Khoshnia, Naser Behnampour, Abdolvahab Moradi
Turkish Journal of Biology
Molecular knowledge regarding the primary esophageal achalasia is essential for the early diagnosis and treatment of this neurodegenerative motility disorder. Therefore, there is a need to find the main microRNAs (miRNAs) contributing to the mechanisms of achalasia. This study was conducted to determine some patterns of deregulated miRNAs in achalasia. This case-control study was performed on 52 patients with achalasia and 50 nonachalasia controls. The miRNA expression profiling was conducted on the esophageal tissue samples using the next-generation sequencing (NGS). Differential expression of miRNAs was analyzed by the edgeR software. The selected dysregulated miRNAs were additionally confirmed using the quantitative …
The Promising Effects Of Bmp2 Transfected Mesenchymal Stem Cells On Humanosteosarcoma, Ahmet Si̇nan Sari, Emre Demi̇rçay, Ahmet Öztürk, Ayşen Terzi̇, Erdal Karaöz
The Promising Effects Of Bmp2 Transfected Mesenchymal Stem Cells On Humanosteosarcoma, Ahmet Si̇nan Sari, Emre Demi̇rçay, Ahmet Öztürk, Ayşen Terzi̇, Erdal Karaöz
Turkish Journal of Biology
Selective targeting of transfected mesenchymal stem cells (MSCs) carrying specific antioncogenes to the tumor was suggested as a treatment option. Bone morphogenetic protein-2 (BMP2) was shown to inhibit the proliferation and aggressiveness of osteosarcoma (OS) cells. Here, we aimed to assess the homing efficiency of intraperitoneally administered hMSCs transfected with BMP2 to the tumoral site and their effects on OS using an orthotopic xenograft murine model. Orthotopic xenograft murine model of OS in sixweek- old female NOD/SCID mice using 143B cells was established. hMSCs transfected with BMP2 (BMP2+hMSC) were used. In vivo experiments performed on four groups of mice that …
Identification Of Serum Predictors Of N-Acetyl-L-Cysteine And Isoproterenol Induced Remodelling In Cardiac Hypertrophy, Dharaniyambigai Kuberapandian, Victor Arokia Doss
Identification Of Serum Predictors Of N-Acetyl-L-Cysteine And Isoproterenol Induced Remodelling In Cardiac Hypertrophy, Dharaniyambigai Kuberapandian, Victor Arokia Doss
Turkish Journal of Biology
Cardiac hypertrophy (CH), leading to cardiac failure is due to chronic metabolic alterations occurring during cellular stress. Besides the already known relationship between oxidative stress and CH, there are implications of reductive stress leading to CH. This study attempted to develop reductive stress-based CH rat model using n-acetyl-L-cysteine (NAC), a glutathione agonist that was compared with typical isoproterenol (ISO) induced CH model. The main objective was to identify serum metabolites that can serve as potent predictors for seven routine clinical and diagnostic parameters in CH: 3-hydroxybutyrate (3-HB), lactic acid (LA), urea, and ECG-CH parameters (QRS complex, R-amplitude, R-R interval, heart …
Analyzing Differentially Expressed Genes And Pathways Of Bex2-Deficient Mouse Lung Via Rna-Seq, Noor Bahadar, Hanif Ullah, Salah Adlat, Rajiv Kumar Sah, May Zun Zaw Myint, Zin Mar Oo, Fatoumata Binta Bah, Farooq Hayel Nagi, Hsu Htoo, Ahmad Ud Din, Xuechao Feng, Yaowu Zheng
Analyzing Differentially Expressed Genes And Pathways Of Bex2-Deficient Mouse Lung Via Rna-Seq, Noor Bahadar, Hanif Ullah, Salah Adlat, Rajiv Kumar Sah, May Zun Zaw Myint, Zin Mar Oo, Fatoumata Binta Bah, Farooq Hayel Nagi, Hsu Htoo, Ahmad Ud Din, Xuechao Feng, Yaowu Zheng
Turkish Journal of Biology
Bex2 is well known for its role in the nervous system, and is associated with neurological disorders, but its role in the lung's physiology is still not reported. To elucidate the functional role of Bex2 in the lung, we generated a Bex2 knock-out (KO) mouse model using the CRISPR-Cas9 technology and performed transcriptomic analysis. A total of 652 genes were identified as differentially expressed between Bex2-/- and Bex2+/+ mice, out of which 500 were downregulated, while 152 were upregulated genes. Among these DEGs, Ucp1, Myh6, Coxa7a1, Myl3, Ryr2, RNaset2b, Npy, Enob1, Krt5, Myl2, Hba-a2, and Nrob2 are the most prominent …
Identification Of Differentially Expressed Genomic Repeats In Primary Hepatocellular Carcinoma And Their Potential Links To Biological Processes And Survival, Gökhan Karakülah, Ci̇hangi̇r Yandim
Identification Of Differentially Expressed Genomic Repeats In Primary Hepatocellular Carcinoma And Their Potential Links To Biological Processes And Survival, Gökhan Karakülah, Ci̇hangi̇r Yandim
Turkish Journal of Biology
Hepatocellular carcinoma (HCC) is one of the deadliest cancers. Research on HCC so far primarily focused on genes and provided limited information on genomic repeats, which constitute more than half of the human genome and contribute to genomic stability. In line with this, repeat dysregulation was significantly shown to be pathological in various cancers and other diseases. In this study, we aimed to determine the full repeat expression profile of HCC for the first time. We utilised two independent RNA-seq datasets obtained from primary HCC tumours with matched normal tissues of 20 and 17 HCC patients, respectively. We quantified repeat …
Investigation Of The Efficacy Of Paclitaxel On Some Mirnas Profiles In Breast Cancer Stem Cells, Eli̇f Ertürk, Ferda Ari, Oğuzhan Akgün, Engi̇n Ulukaya, Cem İsmai̇l Küçükali̇, Şaki̇r Ümi̇t Zeybek
Investigation Of The Efficacy Of Paclitaxel On Some Mirnas Profiles In Breast Cancer Stem Cells, Eli̇f Ertürk, Ferda Ari, Oğuzhan Akgün, Engi̇n Ulukaya, Cem İsmai̇l Küçükali̇, Şaki̇r Ümi̇t Zeybek
Turkish Journal of Biology
Understanding of the functions of microRNAs in breast cancer and breast cancer stem cells have been a hope for the development of new molecular targeted therapies. Here, it is aimed to investigate the differences in the expression levels of let-7a, miR-10b, miR-21, miR-125b, miR-145, miR-155, miR-200c, miR-221, miR-222 and miR-335, which associated with gene and proteins in MCF-7 (parental) and MCF-7s (Mammosphere/stem cell-enriched population/CD44+/CD24-cells) cells treated with paclitaxel. MCF-7s were obtained from parental MCF-7 cells. Cytotoxic activity of paclitaxel was determined by ATP assay. Total RNA isolation and cDNA conversion were performed from the samples. Changes in expression levels of …