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Increasing The Biocompatibility Of Graphene-Based Hybrid Nanostructures With Glycopolymer, Aydan Dağ, Pinar Si̇nem Omurtag Özgen, Belma Zengi̇n Kurt, Zehra Durmuş
Increasing The Biocompatibility Of Graphene-Based Hybrid Nanostructures With Glycopolymer, Aydan Dağ, Pinar Si̇nem Omurtag Özgen, Belma Zengi̇n Kurt, Zehra Durmuş
Turkish Journal of Chemistry
Hybrid nanostructures decorated with glycopolymers are appropriate for biomedical applications. In this paper, the results are obtained from nanographene (NG) decorated with glycoblock copolymer to increase their potential in use in therapies and in examining lectin interactions. A pyren-1-ylmethyl 4-cyano-4-((phenylcarbonothioyl)thio)pentanoate (CPADB-py) chain transfer agent was used in the synthesis of methyl methacrylate glycoblock copolymers (P2 and P3) by reversible addition-fragmentation chain transfer (RAFT) polymerization to adhere the polymer to the nanographene surface. Hybrid nanographenes (NG-1 and NG-2) were obtained by the non-covalent interaction of deprotected P2 and P3 with different fructopyranose groups (3-O-methacryloyl-1,2:4,5- di-O-isopropylidene-β-D-fructopyranose and 1-O-methacryloyl-2,3:4,5-di-O-isopropylidene-β-D-fructopyranose) in their backbones. Images …
Microwave-Assisted Rapid Conjugation Of Horseradish Peroxidase-Dextran Aldehyde With Schiff Base Reaction And Decolorization Of Reactive Blue 19, Mi̇that Çelebi̇, Zafer Ömer Özdemi̇r, Murat Topuzoğullari
Microwave-Assisted Rapid Conjugation Of Horseradish Peroxidase-Dextran Aldehyde With Schiff Base Reaction And Decolorization Of Reactive Blue 19, Mi̇that Çelebi̇, Zafer Ömer Özdemi̇r, Murat Topuzoğullari
Turkish Journal of Chemistry
Microwave irradiation has become a routine technique in homogeneous and effective heating in organic synthesis. However, its application in enzyme-containing reactions is limited since it can cause denaturation of the enzyme. In this study, we have briefly investigated the effect of microwave heating on the conjugation reaction of horseradish peroxidase (HRP) with aldehyde derivative of dextran (D-CHO). The reaction was irradiated by microwave at 50 °C for 5 min. The conjugate was confirmed via GPC, in which the conjugates of HRP and D-CHO coexist with free unbound HRP molecules. Activity studies of HRP revealed that there is a small decrease …
Peg4000 Modified Liposomes Enhance The Solubility Of Quercetin And Improve The Liposome Functionality: In Vitro Characterization And The Cellular Efficacy, Gülen Meli̇ke Demi̇rbolat, Ömer Erdoğan, Gökni̇l Peli̇n Coşkun, Özge Çevi̇k
Peg4000 Modified Liposomes Enhance The Solubility Of Quercetin And Improve The Liposome Functionality: In Vitro Characterization And The Cellular Efficacy, Gülen Meli̇ke Demi̇rbolat, Ömer Erdoğan, Gökni̇l Peli̇n Coşkun, Özge Çevi̇k
Turkish Journal of Chemistry
Quercetin, a multifunctional therapeutic agent, is used in various types of cancer. However, its therapeutic effect is limited by virtue of poorly aqueous solubility and instability in the physiological medium. To overcome these limitations, we aimed (i) to design quercetin loaded liposomes with unlinked-PEG4000 with regard to not only surface modification but also solubility enhancement, and (ii) to investigate the antineoplastic effects on HeLa cells. PEG4000 increased the quercetin solubility 2.2 fold. PEG4000 modified liposomes displayed small particle size (254 ± 69 nm), low polydispersity index (0.236 ± 0.018), favorable zeta potential (-35.4 ± 0.6 mV), high quercetin encapsulation efficiency …
Synthesis And Characterization Of An Electrochromic Copolymer Based On 9, 10-Di (Furan-2-Yl)Anthracene And 3,4-Ethylenedioxythiophene, Ali̇ Kalçik, Ari̇f Kivrak, Buket Çarbaş
Synthesis And Characterization Of An Electrochromic Copolymer Based On 9, 10-Di (Furan-2-Yl)Anthracene And 3,4-Ethylenedioxythiophene, Ali̇ Kalçik, Ari̇f Kivrak, Buket Çarbaş
Turkish Journal of Chemistry
In this study, a new copolymer, which is a combination of two chemical structure (9,10-di(furan-2-yl)anthracene and 3,4-ethylenedioxythiophene was synthesized via electrochemical synthesis methods in the electrolyte medium of 0.1 M TBAPF6/ ACN solution. PEDOT homopolymer was also electrosynthesized for comparator experiments of the polymer formations in the same medium. The characterizations of polymers were achieved with general optical and electrochemical characterization techniques. The corresponding electrochromic copolymer shows blue and lilac color in its neutral and oxidized states, respectively. The copolymer has an optical band gap of 1.65 eV and 24% optical contrast at 500 nm with a high coloration efficiency …
Improved Visible Light-Driven Photocatalytic Degradation Of Methylene Blue And Methyl Red By Boron-Doped Carbon Quantum Dots, Bi̇rcan Haspulat Taymaz, Çi̇sem Kirbiyik Kurukavak, Handan Kamiş, Mahmut Kuş
Improved Visible Light-Driven Photocatalytic Degradation Of Methylene Blue And Methyl Red By Boron-Doped Carbon Quantum Dots, Bi̇rcan Haspulat Taymaz, Çi̇sem Kirbiyik Kurukavak, Handan Kamiş, Mahmut Kuş
Turkish Journal of Chemistry
The synthesis of fluorescent carbon quantum dots (CQDs) and their applications have attracted great attention due to their excellent properties. Especially, the unique visible-light absorption and photo-induced electron transfer properties make CQDs available in photocatalytic degradation of organic dye pollutants in water resources. Herein, we synthesized nondoped CQDs and boron-doped CQDs (B-CQDs) by hydrothermal method and compared their photocatalytic degradation activity of methylene blue (MB) and methyl red (MR) dyes under visible light irradiation. The characterization outcomes showed that the optical and structural properties can be easily improved by doping with hetero-atom, thereby photocatalytic performance. As expected, the photodegradation performance …
On Bounded Solutions Of A Second-Order Iterative Boundary Value Problem, Safa Chouaf, Ahleme Bouakkaz, Rabah Khemis
On Bounded Solutions Of A Second-Order Iterative Boundary Value Problem, Safa Chouaf, Ahleme Bouakkaz, Rabah Khemis
Turkish Journal of Mathematics
In this article, we investigate a second-order iterative differential equation with boundary conditions. The use of the principle of contraction mappings and the Schauder's fixed point theorem allows us to prove some existence and uniqueness results. Finally, an example is given to check the validity of our findings, which are new, and complete some published manuscripts to some degree.
Solvability Of Gripenberg's Equations Of Fractional Order With Perturbation Term In Weighted $L_P$-Spaces On ${\Mathbb{R}}^+$, Mohamed M. A. Metwali
Solvability Of Gripenberg's Equations Of Fractional Order With Perturbation Term In Weighted $L_P$-Spaces On ${\Mathbb{R}}^+$, Mohamed M. A. Metwali
Turkish Journal of Mathematics
This article deals with the solvability of Gripenberg's equations of fractional order with a perturbation term in weighted Lebesgue spaces on ${\mathbb{R}}^+=[0,\infty)$ via the fixed point hypothesis and the measure of noncompactness. The uniqueness of the solutions for the studied problem is discussed. An example is included to validate our results. The results presented in the article extend and generalize some former results in the available literature.
A Sequential Fractional Differential Problem Of Pantograph Type:Existence Uniqueness And Illustrations, Soumia Belarbi, Zoubir Dahmani, Mehmet Zeki̇ Sarikaya
A Sequential Fractional Differential Problem Of Pantograph Type:Existence Uniqueness And Illustrations, Soumia Belarbi, Zoubir Dahmani, Mehmet Zeki̇ Sarikaya
Turkish Journal of Mathematics
In this study, a new class of sequential fractional differential problems of pantograph type is introduced. New existence and uniqueness criteria for the existence and uniqueness of solutions are discussed. Some existence results using Darbo's fixed point and measure of noncompactness are also studied. At the end, two illustrative examples are discussed.
Solving Nonlinear Integro-Differential Equations Using Numerical Method, Nedjem Eddine Ramdani, Sandra Pinelas
Solving Nonlinear Integro-Differential Equations Using Numerical Method, Nedjem Eddine Ramdani, Sandra Pinelas
Turkish Journal of Mathematics
The aim of this paper is to establish conditions for the existence and uniqueness of the solution of a nonlinear integro-differential equation. Moreover, it is to propose a quadrature method in order to find an approximate solution and establish the convergence of the method. We conclude by providing the algorithm and some numerical simulation to confirm our theoretical results.
Multiplicative Conformable Fractional Dirac System, Sertaç Göktaş, Hi̇kmet Kemaloğlu, Emrah Yilmaz
Multiplicative Conformable Fractional Dirac System, Sertaç Göktaş, Hi̇kmet Kemaloğlu, Emrah Yilmaz
Turkish Journal of Mathematics
In multiplicative fractional calculus, the well-known Dirac system in fractional calculus is redefined. The aim of this study is to analyze some spectral properties such as self-adjointness of the operator, structure of all eigenvalues, orthogonality of distinct eigenfunctions, etc. for this system. Moreover, Green's function in multiplicative case is reconstructed for this system.
Existence And Multiplicity Of Solutions For P(.)-Kirchhoff-Type Equations, Rabi̇l Ayazoğlu, Sezgi̇n Akbulut, Ebubeki̇r Akkoyunlu
Existence And Multiplicity Of Solutions For P(.)-Kirchhoff-Type Equations, Rabi̇l Ayazoğlu, Sezgi̇n Akbulut, Ebubeki̇r Akkoyunlu
Turkish Journal of Mathematics
his paper is concerned with the existence and multiplicity of solutions of a Dirichlet problem for $p(.)$-Kirchhoff-type equation% \begin{equation*} \left\{ \begin{array}{c} M\left( \int_{\Omega }\frac{\left\vert \nabla u\right\vert ^{p(x)}}{p(x)}% dx\right) \left( -\Delta _{p(x)}u\right) =f(x,u),\text{ in }\Omega , \\ u=0,\ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \text{on }\partial \Omega .% \end{array}% \right. \end{equation*}% Using the mountain pass theorem, fountain theorem, dual fountain theorem and the theory of …
On Hypersemigroups, Niovi Kehayopulu
On Hypersemigroups, Niovi Kehayopulu
Turkish Journal of Mathematics
This is from the paper "Hypergroupes canoniques values et hypervalues" by J. Mittas in Mathematica Balkanica 1971: "The concept of hypergroup introduced by Fr. MARTY in 1934 [Actes du Congres des Math. Scand. Stocholm 1935, p. 45] is as follows: "A hypergroup is a nonempty set $H$ endowed with a multiplication $xy$ such that, for every $x,y,z\in H,$ the following hold: (1) $xy\subseteq H$; (2) $x(yz)=(xy)z$ and (3) $xH=Hx=H$. The first condition expresses that the multiplication is an hyperoperation on $H$, in other words, the composition of two elements $x,y$ of $H$ is a subset of $H$. It is very …
Analyzing Bifurcation, Stability, And Chaos Control For A Discrete-Time Prey-Predator Model With Allee Effect, Fi̇gen Kangalgi̇l, Ni̇lüfer Topsakal, Ni̇hal Öztürk
Analyzing Bifurcation, Stability, And Chaos Control For A Discrete-Time Prey-Predator Model With Allee Effect, Fi̇gen Kangalgi̇l, Ni̇lüfer Topsakal, Ni̇hal Öztürk
Turkish Journal of Mathematics
In this paper, the qualitative behavior of a discrete-time prey-predator model with Allee effect in prey population is discussed. Firstly, the existence of the fixed points and their topological classification are analyzed algebraically. Then, the conditions of existence for both period-doubling and Neimark--Sacker bifurcations arising from coexistence fixed point with the help of the center manifold theorem and bifurcation theory are investigated. OGY feedback control method is implemented to control chaos in the proposed model due to the emergence of bifurcations. Finally, numerical simulations are performed to support the theoretical findings.
Inverse Nodal Problems For Dirac Type Integro Differential System With A Nonlocal Boundary Condition, Baki̇ Keski̇n
Inverse Nodal Problems For Dirac Type Integro Differential System With A Nonlocal Boundary Condition, Baki̇ Keski̇n
Turkish Journal of Mathematics
In this paper, the Dirac type integro differential system\ with a nonlocal integral boundary condition is considered. First, we derive the asymptotic expressions for the solutions and large eigenvalues. Second, we provide asymptotic expressions for the nodal points and prove that a dense subset of nodal points uniquely determines the boundary condition parameter and the potential function of the considered differential system. We also provide an effective procedure for solving the inverse nodal problem.
Oscillation Of Third-Order Neutral Differential Equations With Oscillatory Operator, Miroslav Bartusek
Oscillation Of Third-Order Neutral Differential Equations With Oscillatory Operator, Miroslav Bartusek
Turkish Journal of Mathematics
A third-order damped neutral sublinear differential equation for which its differential operator is oscillatory is studied. Sufficient conditions are given under which every solution is either oscillatory or the derivative of its neutral term is oscillatory (or it tends to zero).
Morpho-Physiological Diversity Of Barley (Hordeum Vulgare L.) Germplasm For Heat Tolerance, Muhammad Ashraf, Fahad Al-Qurainy, Muhammad Sajid Aqeel Ahmad, Muhammad Yasir Iqbal, Adnan Mehmood, Alia Riffat, Ambreen Khadija Alvi
Morpho-Physiological Diversity Of Barley (Hordeum Vulgare L.) Germplasm For Heat Tolerance, Muhammad Ashraf, Fahad Al-Qurainy, Muhammad Sajid Aqeel Ahmad, Muhammad Yasir Iqbal, Adnan Mehmood, Alia Riffat, Ambreen Khadija Alvi
Turkish Journal of Botany
The aim of the present study was to examine the diversity for heat tolerance in a set of 105 accessions using some key morphophysiological attributes. The data was standardized by calculating percent change over control, and used for phonetic analysis and construction of dendograms based on distance matrix (all primary data is given as supplementary material listed in statistical analysis section of Materials and Methods). These distance matrices were then used for the unweighted pair group method with arithmetic mean (UPGMA) cluster analysis using the sequential agglomerative hierarchical nonoverlapping (SAHN) method. The cluster analysis indicated some potential attributes that could …
In Silico Analysis Of Xth Gene Family From Barley (Hordeum Vulgare L.) And Their Comparative Expression Analysis During Germination, Hülya Akdemi̇r Koç, Merve Seven, Ümi̇t Cem Derman, Andrew John Harvey
In Silico Analysis Of Xth Gene Family From Barley (Hordeum Vulgare L.) And Their Comparative Expression Analysis During Germination, Hülya Akdemi̇r Koç, Merve Seven, Ümi̇t Cem Derman, Andrew John Harvey
Turkish Journal of Botany
Changes in plant cell walls are critical for expansion and growth. Xyloglucan endotransglycosylase/hydrolase (XTH) enzymes are the major modifiers of xyloglucan within the cell wall and are present as large gene families. Despite the paucity of xyloglucan in barley, our analyses of the barley genome revealed at least 42 XTH genes, the most XTH members recorded for a monocot genome to date. In this paper, we show a detailed look at the barley XTH gene family, including detailed bioinformatics analyses of conserved protein motifs and structure, phylogenetic relationships, and a comparison of the expression patterns during germination and seedling growth …
New Species And New Record In Agaricus Subg. Minores From India, Entaj Tarafder, Arun Kumar Dutta, Krishnendu Acharya
New Species And New Record In Agaricus Subg. Minores From India, Entaj Tarafder, Arun Kumar Dutta, Krishnendu Acharya
Turkish Journal of Botany
Two new species of Agaricus, namely A. midnapurensis and A. purpureosquamulosus, belonging to A. subg. Minores, are proposed here as new to science based on specimens collected in West Bengal, India. Agaricus midnapurensis is distinguished by its medium-sized basidiomata with a pileus covered by greyish brown to brown or dark brown squamules, ellipsoid to broadly ellipsoid basidiospores with a mean value of 7.3 × 5.4 µm, and broadly clavate to pyriform cheilocystidia, 22-28 × 10-14 µm. Agaricus purpureosquamulosus has purplish coloured pileus squamules, ellipsoid to elongate basidiospores with a mean value of 7.3 × 4.5 µm, and clavate cheilocystidia measuring …
Shackletonia Backorii - A New Species Of Lichenised Fungus From James Ross Island (Antarctic Peninsula), Mehmet Gökhan Halici, Mi̇that Güllü, Ekrem Bölükbaşi, Merve Kahraman Yi̇ği̇t
Shackletonia Backorii - A New Species Of Lichenised Fungus From James Ross Island (Antarctic Peninsula), Mehmet Gökhan Halici, Mi̇that Güllü, Ekrem Bölükbaşi, Merve Kahraman Yi̇ği̇t
Turkish Journal of Botany
The new lichen species Shackletonia backorii Halıcı, Güllü & Kahraman is described from James Ross Island, which is located in the North-East Antarctic Peninsula region. The new species is morphologically most similar to S. insignis (Søchting & Øvstedal) Søchting, Frödén & Arup, which was described from Livingstone Island (North-West Antarctic Peninsula region). These two species have a similar bluish grey to blackish thallus with a microfruticose and coralloid structure and red brown or almost black zeorine apothecia, but S. backorii has rhomboid ascospores and grows on soil whereas S. insignis has ellipsoid ascospores and occurs in sheltered crevices of rocks. …
Genome-Wide Identification And Evolutionary Analysis Of Cngc Gene Families In Sixteen Brassicaceae Plant Genomes, Akram Ali Baloch, Kaleem U. Kakar, Asma Abro, Muhammad Mushtaq, Zarqa Nawaz, Abrar Hussain
Genome-Wide Identification And Evolutionary Analysis Of Cngc Gene Families In Sixteen Brassicaceae Plant Genomes, Akram Ali Baloch, Kaleem U. Kakar, Asma Abro, Muhammad Mushtaq, Zarqa Nawaz, Abrar Hussain
Turkish Journal of Botany
Cyclic nucleotide-gated channels (CNGCs) are ligand-gated calcium signaling channels, play vital biological functions. Nonetheless, the CNGC gene families have not been well studied in Brassicaceae which includes commercially important and evolutionary model crops. Here, using in silico approaches, we recognized 414 CNGC genes in sixteen sequenced genomes of Brassicaceae species, which represent 10 genera of 8 tribes, ranging between 10-51 genes. These CNGCs can be classified into four main groups (I-IV) and two subgroups (IV-A and IV-B), of which, Group-II CNGC is the oldest that has gradually disappeared from the Arabis alpina L. genome. These results present a comprehensive overview …
Green Synthesis, Characterisation Of Au And Ag Nanoparticles By Various Bioextracts And Their Usability At Graphite Electrode Modification, Emi̇ne Arslan, Ender Bi̇çer, Eli̇f Sekmen, Semi̇ha Çakir
Green Synthesis, Characterisation Of Au And Ag Nanoparticles By Various Bioextracts And Their Usability At Graphite Electrode Modification, Emi̇ne Arslan, Ender Bi̇çer, Eli̇f Sekmen, Semi̇ha Çakir
Turkish Journal of Chemistry
In this study, the biosynthesis of Au and Ag nanoparticles (AuNp and AgNp) with a green chemistry approach was performed by using bioextracts of various fruits and vegetables (Lycopersicon esculentum (LE), Cucumis sativus (CS), Malus domestica (MD), Cucurbita pepo (CP), Apiumgraveolens var. rapaceum (AVR), Prunus cerasifera (PC), Oleraceae var. botrytis (OVB)). In the determination of optimum experimental conditions, the parameters such as the type and concentration of bioextract, concentration of metal ion solutions, the ratio of metal ion solution to bioextract, pH, reaction time and temperature were found to be significant. The characterisation of AuNp and AgNp synthesized by providing …
Synthesis And Reactions Of Di(Thiophen-2-Yl)Alkane Diones: Cyclocondensation, Teki̇n Artunç, Abdullah Menzek
Synthesis And Reactions Of Di(Thiophen-2-Yl)Alkane Diones: Cyclocondensation, Teki̇n Artunç, Abdullah Menzek
Turkish Journal of Chemistry
Known 1,6-di(thiophen-2-yl)hexane-1,6-dione (2) and novel 1,7-di(thiophen-2-yl)heptane-1,7-dione (4) were obtained from the reactions of thiophene with the corresponding diacyl chlorides. Furthermore, compounds with furan and pyrrole units in place of thiophene units in compound 2 were obtained in the same way. Bromination of 2 and 4 gave bromides regioselectively. The reaction of each of the compounds 2 and 4 in HOAc medium yielded cyclocondensation products. In total, four known and eleven novel compounds were synthesized.
Schiff Base Containing Pyridine Groups Functionalized Water-Soluble Phthalocyanine: Synthesis, Photo-Physicochemical Properties, And Bovine Serum Albumin Binding Behavior, Öznur Dülger, Ali̇ Erdoğmuş
Schiff Base Containing Pyridine Groups Functionalized Water-Soluble Phthalocyanine: Synthesis, Photo-Physicochemical Properties, And Bovine Serum Albumin Binding Behavior, Öznur Dülger, Ali̇ Erdoğmuş
Turkish Journal of Chemistry
The novel pyridine bearing schiff base substituted metal-free (9), zinc(II) phthalocyanine (10), and its quaternized derivative (11) were designed and synthesized. These phthalocyanines were fully characterized by spectroscopic methods (FT-IR, UV-Vis, MALDI-TOF, and 1H NMR). The photo-physicochemical properties of these phthalocyanines were investigated in both DMSO and DMF for 10 and in both DMSO and aqueous solution for 11. The addition of pyridine bearing Schiff base groups as peripheral ligands showed an improvement in the photophysical and photochemical properties. In addition, a spectroscopic investigation of the binding behavior of the water-soluble zinc (II) phthalocyanine …
Comparison Of Denaturing Agent Effects In Enzymatic N-Glycan Release For Human Plasma N-Glycan Analysis, Haci Mehmet Kayili, Rokia Sakhta, Beki̇r Sali̇h
Comparison Of Denaturing Agent Effects In Enzymatic N-Glycan Release For Human Plasma N-Glycan Analysis, Haci Mehmet Kayili, Rokia Sakhta, Beki̇r Sali̇h
Turkish Journal of Chemistry
Glycosylation is an essential posttranslational modification observed in the living proteome. Glycosylation profiles in glycoproteins can change in commonly observed diseases such as cancer. Identifying these changes is crucial in discovering new biomarkers for the early diagnosis of cancer. One of the main steps of N-glycan analysis is to release N-glycans from glycoproteins by specific enzymes. The study compares common denaturing agent combinations used in N-glycan release methods. In the study, human plasma was used to test the release methods of N-glycans containing different detergent combinations. The released N-glycans were labeled with the procainamide tag, …
Interaction Of The Nitrogen-Containing Carbon Backbone Polymers With Essential Α-Amino Acids, Andrey Sorokin, Maria Lavlinskaya
Interaction Of The Nitrogen-Containing Carbon Backbone Polymers With Essential Α-Amino Acids, Andrey Sorokin, Maria Lavlinskaya
Turkish Journal of Chemistry
The aim of this work is to research the interactions of water-soluble nitrogen-containing copolymers with essential amino acids in aqueous media. For this, poly(N-vinylformamide-co-N-vinylimidazole) and poly(N-vinylcaprolactam-co-N-vinylimidazole) random copolymers were synthesized by free radical polymerization. The products obtained are characterized by GPC, DLS, and FTIR. The copolymers have a narrow molecular weight distribution and low dispersity. The interactions of the obtained copolymers with histidine, proline, arginine, leucine, phenylalanine, and methionine were researched by UV spectroscopy, FTIR, and TEM. It was found that conjugation of the copolymers with amino acids correlates with the copolymer …
The Investigation Of Parameters Affecting Ibrutinib Release From Chitosan/ Tripolyphosphate/Carbon Nanofiber Composite Microspheres, Canan Armutcu
The Investigation Of Parameters Affecting Ibrutinib Release From Chitosan/ Tripolyphosphate/Carbon Nanofiber Composite Microspheres, Canan Armutcu
Turkish Journal of Chemistry
This study described the performance of carbon nanofiber modified chitosan (CNF@CS) composite microspheres for the controlled release of the Ibrutinib (IBR) drug. The surface morphology, particle sizes, and functional group contents of the microspheres were characterized by attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron, and optical microscopy measurements. The obtained data demonstrated that the addition of CNF to the microsphere increased the encapsulation efficiency of the IBR while allowing the controlled and gradual release of the drug. In terms of the encapsulation efficiency and drug release rate, IBR@CS/TPP/CNF microspheres, achieving drug encapsulation efficiency of 83.09%, have the most …
Determination Of Essential Oil And Biological Activities Of Hypericum Ternatum Poulter And H. Scabrum L. Species Collected From Different Localities: Is H. Scabrum An Alternative To Multifunctional Species St John's Wort (H. Perforatum)?, Mehmet Akdeni̇z, İsmai̇l Yener, Sevgi̇ İrtegün Kandemi̇r, Şafak Özhan Kocakaya, Mehmet Firat, Serkan Yi̇ği̇tkan, Nesri̇n Haşi̇mi̇ Besen, Abdulselam Ertaş, Ufuk Kolak
Determination Of Essential Oil And Biological Activities Of Hypericum Ternatum Poulter And H. Scabrum L. Species Collected From Different Localities: Is H. Scabrum An Alternative To Multifunctional Species St John's Wort (H. Perforatum)?, Mehmet Akdeni̇z, İsmai̇l Yener, Sevgi̇ İrtegün Kandemi̇r, Şafak Özhan Kocakaya, Mehmet Firat, Serkan Yi̇ği̇tkan, Nesri̇n Haşi̇mi̇ Besen, Abdulselam Ertaş, Ufuk Kolak
Turkish Journal of Chemistry
The importance of Hypericum L. species, being used in traditional medicine, in the scientific world is increasing day by day. Hypericum species are plants that have been used in the treatment of many diseases for a long time and have healing properties. In the current study, the essential oil compositions of Hypericum scabrum L. and H. ternatum Poulter collected from different localities in Turkey were determined by GC-MS/FID. In addition, their antioxidant, cytotoxic, and antimicrobial activities with their enzyme inhibitory potentials (cholinesterase, urease, tyrosinase, elastase, and collagenase) were investigated. Also, in vitro and in silico studies of the major components …
First Determination Of Anticancer, Cytotoxic, And In Silico Adme Evaluation Of Secondarymetabolites Of Endemic Astragalus Leucothrix Freyn & Bornm, Ayşe Şahi̇n Yağlioğlu, Duygu Güneş Gürbüz, Melda Dölarslan, İbrahi̇m Demi̇rtaş
First Determination Of Anticancer, Cytotoxic, And In Silico Adme Evaluation Of Secondarymetabolites Of Endemic Astragalus Leucothrix Freyn & Bornm, Ayşe Şahi̇n Yağlioğlu, Duygu Güneş Gürbüz, Melda Dölarslan, İbrahi̇m Demi̇rtaş
Turkish Journal of Chemistry
Isolation and characterization of anticancer activity guided secondary metabolites of endemic Astragalus leucothrix Freyn& Bornm were aimed. Aerial parts of the plant were extracted by maceration method in the solvent system methanol-chloroform (1 : 1) at room temperature. The obtained crude extract was dissolved in purified water. Then, the extract was partitioned with n-hexane, chloroform, ethyl acetate, and n-butanol, respectively. Anticancer activity tests of all the fractions were performed against HeLa and C6 cancer cells. The chloroform fraction that has highest anticancer activity was subjected to chromatographic methods such as column chromatography and thin layer chromatography. Pentyl tetratetracontanoate (1), alfalone …