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Articles 571 - 600 of 1022
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Analyzing Formation Of Silver Nanoparticles From The Filamentous Fungus Fusarium Oxysporum And Their Antimicrobial Activity, Abd-Almohaimen Ahmed, Haider Hamzah, Mohammed Maaroof
Analyzing Formation Of Silver Nanoparticles From The Filamentous Fungus Fusarium Oxysporum And Their Antimicrobial Activity, Abd-Almohaimen Ahmed, Haider Hamzah, Mohammed Maaroof
Turkish Journal of Biology
In recent years much attention has been paid to the biosynthesis of silver nanoparticles (AgNPs) and their important medical applications. The current study employs Fusarium oxysporum for the formation of silver nanoparticles and examines the antimicrobial activity of the particles against some multidrug-resistant (MDR) microbes. Silver nitrate was transformed into silver oxide, forming well-dispersed nanoparticles, by the action of F. oxysporum metabolically. The size of the nanoparticles ranged from 21.3 to 37.3 nm, and UV-spectroscopy showed a peak at 408-411 nm. Moreover, SEM, TEM, and AFM results revealed spherical and oval shapes and showed no sign of aggregation. Furthermore, the …
Relationship Between Pk2 And Number Of Kupffer Cells Duringthe Progression Of Liver Fibrosis In Patients With Hbv, Xiao-Qin Liu, Rong-Rong Wei, Cheng-Cheng Wang, Li-Yu Chen, Cong Liu, Kai Liu
Relationship Between Pk2 And Number Of Kupffer Cells Duringthe Progression Of Liver Fibrosis In Patients With Hbv, Xiao-Qin Liu, Rong-Rong Wei, Cheng-Cheng Wang, Li-Yu Chen, Cong Liu, Kai Liu
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the potential regulatory role of prokineticin 2 (PK2) in modulation of the number and function of Kupffer cells (KCs) during the progression of liver fibrosis in patients with hepatitis B virus (HBV). Materials and methods: We obtained liver tissue sections from 200 patients with HBV undergoing surgical resection in our hospital between January 2013 and July 2016. Of these 200 tissue sections, 150 were fibrosis tissues and 50 were hepatocellular carcinoma tissues. Immunohistochemical evaluations were performed to assess the expression levels of CD68 and PK2 in the sections. The clinical parameters of these 200 …
Peripheral Arterial Disease Increases The Risk Of Multidrug-Resistant Bacteria Andamputation In Diabetic Foot Infections, Pinar Aysert Yildiz, Tuğba Özdi̇l, Murat Di̇zbay, Özlem Güzel Tunçcan, Kenan Hizel
Peripheral Arterial Disease Increases The Risk Of Multidrug-Resistant Bacteria Andamputation In Diabetic Foot Infections, Pinar Aysert Yildiz, Tuğba Özdi̇l, Murat Di̇zbay, Özlem Güzel Tunçcan, Kenan Hizel
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the microbiological profile and resistance rates of diabetic foot infections (DFIs) and to determine the effect of peripheral arterial disease (PAD) on the microbiology, clinical condition, and treatment outcomes. Materials and methods: Characteristics, laboratory and imaging data, and the treatment modalities of patients admitted to our hospital with a diagnosis of DFI (PEDIS classification 3-4) during 2005-2016 were analyzed according to the presence of PAD. Results: Of 112 patients who were included in this study, 86 (76.8%) had PAD. Patients with PAD were older and had higher amputation rates (P < 0.05). A microbiological profile of patients revealed a predominance of gram-positive bacteria (57.1%). Staphylococcus aureus and Streptococcus spp. were the most frequently encountered bacteria. Incidence of Pseudomonas spp. infection was higher in the PAD group (P < 0.05). Of all patients, 24.1% had multidrug-resistant (MDR) microorganisms in their wound cultures. Presence of MDR bacteria in patients with PAD was 4.9-fold higher than that in patients without PAD (P < 0.05). Conclusion: This retrospective study indicates that PAD has a significant role, especially in elderly patients with DFIs. Patients should be promptly evaluated and treated for PAD to prevent infections with resistant microorganisms and limb loss.
Factors Influencing The Success Of Cord Blood Collection: A Tertiary Perinatal Medicinecenter's Experience, Atakan Tanaçan, Pinar Yurdakul Mesutoğlu, Fati̇h Aktoz, Gökçen Örgül, Meral Beksaç, Mehmet Si̇nan Beksaç
Factors Influencing The Success Of Cord Blood Collection: A Tertiary Perinatal Medicinecenter's Experience, Atakan Tanaçan, Pinar Yurdakul Mesutoğlu, Fati̇h Aktoz, Gökçen Örgül, Meral Beksaç, Mehmet Si̇nan Beksaç
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the effects of certain maternal, fetal, and umbilical cord blood unit factors on storage and/or discard incidence of collected cord blood units from perinatal medicine patients. Materials and methods: A total of 273 cord blood units collected between January 2011 and December 2016 in the Division of Perinatology of Hacettepe University Hospital were evaluated retrospectively in this study. Results: Of the collected cord blood units, 53.8% (147/273) were stored. Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were statistically significantly different between the eligible and discarded cord …
Parvovirus B19 Seroprevalence In Turkish Blood Donors, Şeni̇z Göral, İdi̇l Yeni̇cesu, Gülendam Bozdayi, Aysu Duyan Çamurdan, Ayli̇n Altay Koçak
Parvovirus B19 Seroprevalence In Turkish Blood Donors, Şeni̇z Göral, İdi̇l Yeni̇cesu, Gülendam Bozdayi, Aysu Duyan Çamurdan, Ayli̇n Altay Koçak
Turkish Journal of Medical Sciences
Background/aim: Parvovirus risk in blood transfusion has become a popular research topic since there are limited data on parvovirus seroprevalence in blood donors in Turkey. The aim of this study was to investigate parvovirus seroprevalence in blood donors in Turkey. Materials and methods: Blood samples of 988 blood donors admitted to a university blood bank were obtained for parvovirus B19 IgM and IgG detection. The samples were analyzed using the ELISA method. Results: IgM positivity of 3.92% and IgG positivity of 58.9% was detected in the blood samples. Parvovirus IgM positivity was found to be the highest in the age …
The Prevalence And Genetic Diversity Of Feline Immunodeficiency Virusand Feline Leukemia Virus Among Stray Cats In Harbin, China, Mei-Qiao Pan, Jiu-Cheng Wang, Ya-Jun Wang
The Prevalence And Genetic Diversity Of Feline Immunodeficiency Virusand Feline Leukemia Virus Among Stray Cats In Harbin, China, Mei-Qiao Pan, Jiu-Cheng Wang, Ya-Jun Wang
Turkish Journal of Zoology
Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) are typical retroviruses that are transmitted horizontally among felines. FIV results in symptoms of immunodeficiency such as weight loss, chronic lesions, opportunistic infections, and neurological abnormalities, while FeLV is known to cause a variety of neoplastic and nonneoplastic diseases in cats, such as thymic lymphoma, multicentric lymphoma myelodysplastic syndromes, acute myeloid leukemia, aplastic anemia, and immunodeficiency. The prevalence and genetic diversity of FIV and FeLV in stray cats have not been investigated. In this study, polymerase chain reaction and enzyme-linked immunosorbent assay were used to test 198 blood samples from stray …
Comparative Clinical And Parasitological Efficacy Of Moxidectin Pour-On, Ivermectin, And Piperazine Citrate On Toxocara Vitulorum Infection In Buffalo Calves (Bubalus Bubalis):A Randomized Clinical Trial, Mohamed Abdo Rizk, Salama A. Osman, Magdy H. Al-Gaabary, Sabry A. Elkhodery
Comparative Clinical And Parasitological Efficacy Of Moxidectin Pour-On, Ivermectin, And Piperazine Citrate On Toxocara Vitulorum Infection In Buffalo Calves (Bubalus Bubalis):A Randomized Clinical Trial, Mohamed Abdo Rizk, Salama A. Osman, Magdy H. Al-Gaabary, Sabry A. Elkhodery
Turkish Journal of Veterinary & Animal Sciences
Toxocara vitulorum is an important intestinal nematode that causes great economic losses in farm animals worldwide. However, there is a paucity in the development of effective and safe anthelmintic drugs against this parasite in buffalo calves. Therefore, this study aimed to evaluate the antitoxocariasis efficacy of moxidectin, ivermectin, and piperazine citrate in buffalo calves. To achieve this purpose, 130 buffalo calves were randomly selected from Kafr El-Sheikh governorate, Egypt, and were examined for the presence of Toxocara vitulorum. Thirty calves were identified to be infected. Diseased calves were allocated randomly into 3 groups (10 each). The first group received moxidectin …
Congenital Tuberculosis In A 25-Day-Old Female Calf, Maria Del Carmen Espejel Del Moral, Juan Carlos Del Rio, Alfredo Medrano, Marco Antonio Santillan, Jose Francisco Morales
Congenital Tuberculosis In A 25-Day-Old Female Calf, Maria Del Carmen Espejel Del Moral, Juan Carlos Del Rio, Alfredo Medrano, Marco Antonio Santillan, Jose Francisco Morales
Turkish Journal of Veterinary & Animal Sciences
A female calf, housed in a dairy intensive-system farm, suddenly died 25 days after birth. Routine necropsy revealed multiple variably sized white to yellowish nodules in the lungs. Histopathological diagnosis showed severe granulomatous pneumonia with acid-fast bacilli; Mycobacterium bovis was confirmed by polymerase chain reaction and culture isolation. Congenital tuberculosis was diagnosed based on these findings. The calf probably acquired the infection from her mother through aspiration of the amniotic fluid. The aim here is to describe the morphological lesions and complementary confirmation of congenital tuberculosis in a young female calf.
Immunogenicity Of Transmembrane Deleted-G Protein Of Bovine Ephemeral Fever Virus (Befv) Expressed In Insect Cells, Nattawadee Kanpipit, Challika Kaewborisuth, Teerapat Rungnirundorn, Nantawan Petcharat, Porntippa Lekcharoensuk
Immunogenicity Of Transmembrane Deleted-G Protein Of Bovine Ephemeral Fever Virus (Befv) Expressed In Insect Cells, Nattawadee Kanpipit, Challika Kaewborisuth, Teerapat Rungnirundorn, Nantawan Petcharat, Porntippa Lekcharoensuk
Turkish Journal of Veterinary & Animal Sciences
Bovine ephemeral fever (BEF) is a common febrile disease in cattle in tropical countries causing loss of milk production and reproductive performance. Recently, severe outbreaks have occurred in many countries in East Asia, the Middle East, and Southeast Asia, especially in the rainy season, while limited vaccines and diagnostic tools are available. Thus, the aim of this study was to produce a secreted, soluble form of BEFV G glycoprotein in insect cells for further applications. BEFV G gene expressing transmembrane-deleted G glycoprotein (G?TM) was constructed and cloned into the baculovirus vector. The recombinant G?TM protein was expressed in High5 insect …
Comparison Of The In Vitro Anticancer Effect Of Habanero Pepper Extract Containing Capsaicin With That Of Pure Capsaicin In Selected Dog Neoplastic Cell Lines, Lukasz Adaszek, Olga Slabczy?Ska, Pawel Lyp, Dagmara Gadomska, Jerzy Zietek, Dorota Rozanska, Maciej Orzelski, Anna Smiech, Marta Staniec, Dorota Krasucka, Stanislaw Winiarczyk
Comparison Of The In Vitro Anticancer Effect Of Habanero Pepper Extract Containing Capsaicin With That Of Pure Capsaicin In Selected Dog Neoplastic Cell Lines, Lukasz Adaszek, Olga Slabczy?Ska, Pawel Lyp, Dagmara Gadomska, Jerzy Zietek, Dorota Rozanska, Maciej Orzelski, Anna Smiech, Marta Staniec, Dorota Krasucka, Stanislaw Winiarczyk
Turkish Journal of Veterinary & Animal Sciences
The aim of this article was to assess the anticancer effectiveness of habanero pepper extract containing capsaicin on two dog cancer lines, DAN (fibroblasts isolated from osteosarcoma) and D-17 (epithelium cells of osteosarcoma obtained from pulmonary metastatic tumors), under in vitro conditions. The experiment was carried out in a suspension of D-17 and DAN line cells with a density of 12 × 105 cells/mL in a culture fluid with 10% of FBS. After 24 h of incubation (37 °C, 5% CO2), the fluid above the culture was removed, and diluted habanero pepper extract was added. The concentrations of capsaicin in …
Comparison Of Igg And Semiquantitative Tests For Evaluation Of Passive Transfer Immunity In Calves, Onur Topal, Hasan Batmaz, Zafer Meci̇toğlu, Ender Uzabaci
Comparison Of Igg And Semiquantitative Tests For Evaluation Of Passive Transfer Immunity In Calves, Onur Topal, Hasan Batmaz, Zafer Meci̇toğlu, Ender Uzabaci
Turkish Journal of Veterinary & Animal Sciences
Serum immunoglobulin (IgG) and semiquantitative tests are used for the evaluation of passive transfer immunity (PTI) in calves. We aimed to evaluate PTI in calves by using a Brix refractometer, total protein (TP), gamma-glutamyl transferase (GGT), and glutaraldehyde coagulation test (GCT) on days 1, 3, and 7 after birth; to compare the results with serum IgG; and to evaluate which day these tests are given on will give the best results. The blood samples were collected from 60 Holstein dairy calves on day 0, just after birth, and on the 1st, 3rd, and 7th days after birth. The serum IgG …
He Scenario Tree Epidemiological Model In Estimation Effects Of B. Melitensis Rev 1 Vaccination On Disease Prevalence, Sabina Seric Haracic, Nihad Fejzic, Ermin Saljic, Dzenita Hadzijunuzovic Alagic, Mo Salman
He Scenario Tree Epidemiological Model In Estimation Effects Of B. Melitensis Rev 1 Vaccination On Disease Prevalence, Sabina Seric Haracic, Nihad Fejzic, Ermin Saljic, Dzenita Hadzijunuzovic Alagic, Mo Salman
Turkish Journal of Veterinary & Animal Sciences
minant brucellosis. The stochastic scenario tree model was used to simulate vaccination and surveillance implementation during 8 years. Outputs were annual proportions of true positive, true negative, false positive, and false negative flocks. Vaccination coverage was described by the Pert distribution with average 70% and min and max 50% and 80%, respectively. Effects of risk factors (high prevalence-areas and transhumance) were considered. The model was separately simulated for three levels of initial average flock prevalence (2%, 5%, and 10%). In the following years, flock prevalence arising from the fitted distribution of the false negative flocks from the previous year increased …
Antibiotic Treatment Outcomes In Community-Acquired Pneumonia, Aykut Çi̇lli̇, Abdullah Sayiner, Burcu Çelenk, Ayşin Şakar Coşkun, Oğuz Kilinç, Armağan Hazar, Anil Aktaş Samur, Sezai̇ Taşbakan, Grant W. Waterer, Yavuz Havlucu, Öznur Kiliç, Fatma Tokgöz, Uğur Bi̇lge
Antibiotic Treatment Outcomes In Community-Acquired Pneumonia, Aykut Çi̇lli̇, Abdullah Sayiner, Burcu Çelenk, Ayşin Şakar Coşkun, Oğuz Kilinç, Armağan Hazar, Anil Aktaş Samur, Sezai̇ Taşbakan, Grant W. Waterer, Yavuz Havlucu, Öznur Kiliç, Fatma Tokgöz, Uğur Bi̇lge
Turkish Journal of Medical Sciences
Background/aim: The optimal empiric antibiotic regimen for patients with community-acquired pneumonia (CAP) remains unclear. This study aimed to evaluate the clinical cure rate, mortality, and length of stay among patients hospitalized with communityacquired pneumonia in nonintensive care unit (ICU) wards and treated with a ß-lactam, ß-lactam and macrolide combination, or a fluoroquinolone. Materials and methods: This prospective cohort study was performed using standardized web-based database sheets from January 2009 to September 2013 in nine tertiary care hospitals in Turkey. Results: Six hundred and twenty-one consecutive patients were enrolled. A pathogen was identified in 78 (12.6%) patients. The most frequently isolated …
The In Vitro Effect Of Antimicrobial Photodynamic Therapy Oncandida And Staphylococcus Biofilms, Özlem Güzel Tunçcan, Ayşe Kalkanci, Eli̇f Ayça Ünal, Olkar Abdulmajed, Merve Erdoğan, Murat Di̇zbay, Kayhan Çağlar
The In Vitro Effect Of Antimicrobial Photodynamic Therapy Oncandida And Staphylococcus Biofilms, Özlem Güzel Tunçcan, Ayşe Kalkanci, Eli̇f Ayça Ünal, Olkar Abdulmajed, Merve Erdoğan, Murat Di̇zbay, Kayhan Çağlar
Turkish Journal of Medical Sciences
Background/aim: This study was designed to evaluate the effect of antimicrobial photodynamic treatment (APDT) in a biofilm model using combinations of various dyes (rose bengal, riboflavin, and methylene blue) as photosensitizers and light sources (LED and UVA) against staphylococcal and candidal biofilms. Materials and methods: Sterile microtiter plates were used for the development and quantification of the biofilms. APDT was carried out using combinations of the light sources and dyes. The percentage of the growth inhibition was then calculated using a spectrophotometer. The broth media in the wells were aspirated, wells were stained with crystal violet, and optical density values …
Cyclosporine-A For Severe Childhood Atopic Dermatitis: Clinical Experience On Efficacyand Safety Profile, Hayri̇ye Saricaoğlu, Serkan Yazi̇ci̇, Özge Zorlu, Emel Bülbül Başkan, Kenan Aydoğan
Cyclosporine-A For Severe Childhood Atopic Dermatitis: Clinical Experience On Efficacyand Safety Profile, Hayri̇ye Saricaoğlu, Serkan Yazi̇ci̇, Özge Zorlu, Emel Bülbül Başkan, Kenan Aydoğan
Turkish Journal of Medical Sciences
Background/aim: Management of atopic dermatitis (AD) in children is still challenging. The aim of this study was to evaluate the efficacy and safety profile of cyclosporine-A (CsA) treatment in children with severe and recalcitrant AD. Materials and methods: Medical records of 43 children followed between January 2010 and December 2015 and treated with systemic CsA were evaluated retrospectively. Treatment efficacy was assessed according to the physician's global assessment (PGA) score. According to the treatment response, patients were grouped as nonresponder, moderate responder, or good responder. Effects of the variables on treatment response were evaluated by analysis of variance (ANOVA). The …
Invasive Nontyphoidal Salmonella Disease In Southern India: A 5-Year Experience From Atertiary Care Hospital, Sudipta Patra, Yasha Mukim, Muralidhar Varma, Chiranjay Mukhopadhyay
Invasive Nontyphoidal Salmonella Disease In Southern India: A 5-Year Experience From Atertiary Care Hospital, Sudipta Patra, Yasha Mukim, Muralidhar Varma, Chiranjay Mukhopadhyay
Turkish Journal of Medical Sciences
Background/aim: The current study was carried out to describe the clinical presentation, antimicrobial susceptibility pattern, and outcome of invasive nontyphoidal Salmonella disease (iNTS) in a tertiary care center. Materials and methods: A 5-year hospital-based retrospective study was carried out on blood culture-confirmed cases of iNTS. Medical records of patients were reviewed to obtain information on demography, clinical manifestations, comorbidities, complications, immune status, treatment, and clinical outcome. Results: A total of 40 blood culture-confirmed cases of iNTS were diagnosed during the study period. Among these 40 isolates, 9 (22.5%) were identified as Salmonella Typhimurium. Fever (67.5%) with gastrointestinal disturbance (40%) was …
The First Case Of Traumatic Myiasis Caused By Musca Domestica In A Dog In Konya, Turkey, Bi̇lal Di̇k, Ceylan İlhan, Onur Ceylan, Elgi̇n Orçum Uzunlu
The First Case Of Traumatic Myiasis Caused By Musca Domestica In A Dog In Konya, Turkey, Bi̇lal Di̇k, Ceylan İlhan, Onur Ceylan, Elgi̇n Orçum Uzunlu
Turkish Journal of Veterinary & Animal Sciences
A case of traumatic myiasis caused by the Musca domestica (Linnaeus 1758) housefly was detected in a dog in Konya, Turkey. A 4-year-old Kangal breed dog injured in a traffic accident was brought to the surgery clinic of the Faculty of Veterinary Medicine at Selçuk University in Konya, Turkey for treatment. Several dipterous larvae were collected from the wound of the dog, placed in a petri dish with 70% ethanol, and sent to the parasitology laboratory for identification. The larvae were examined macroscopically. The specimens were identified as third-instar larvae of M. domestica. This is the first report of traumatic …
Determinants And Characteristics Of Tuberculosis In Liver Transplant Recipients, Ayli̇n Özgen Alpaydin, Mücahi̇t Özbi̇lgi̇n, Madina Abdullayeva, Selver Seda Mersi̇n, Tufan Egeli̇, Tarkan Ünek, Oğuz Kilinç, İbrahi̇m Kemal Astarcioğlu, Vi̇ldan Avkan Oğuz
Determinants And Characteristics Of Tuberculosis In Liver Transplant Recipients, Ayli̇n Özgen Alpaydin, Mücahi̇t Özbi̇lgi̇n, Madina Abdullayeva, Selver Seda Mersi̇n, Tufan Egeli̇, Tarkan Ünek, Oğuz Kilinç, İbrahi̇m Kemal Astarcioğlu, Vi̇ldan Avkan Oğuz
Turkish Journal of Medical Sciences
Background/aim: Solid organ transplant (SOT) recipients have increased risk of tuberculosis (TB). We aimed to investigate the prevalence and features of TB in liver transplant (LT) recipients at our transplantation canter. Materials and methods: All patients who underwent LT between January 2004 and December 2013 and whose data were accessible were included in the study. Demographic features, tuberculin skin test (TST) results, and TB prevalence were recorded. Characteristics of LT recipients who developed TB were evaluated. Results: A total of 403 patients underwent LT during this period. Mean age was 47.27 ± 11.04 years; 280 (69.47%) were males. The TST …
Angiostatin Levels In Diabetes Mellitus Patients Receiving Insulin Treatment: Associations With Laboratory Findings, Comorbidities, And Medications, İsmai̇l Ertürk, Erdi̇m Sertoğlu, Fati̇h Yeşi̇ldal, Ramazan Acar, Taner Özgürtaş, Kenan Sağlam
Angiostatin Levels In Diabetes Mellitus Patients Receiving Insulin Treatment: Associations With Laboratory Findings, Comorbidities, And Medications, İsmai̇l Ertürk, Erdi̇m Sertoğlu, Fati̇h Yeşi̇ldal, Ramazan Acar, Taner Özgürtaş, Kenan Sağlam
Turkish Journal of Medical Sciences
Background/aim: The clinical effect of angiostatin in diabetes mellitus (DM) patients receiving insulin is a meaningful gap in the literature. In this study, we aimed to show the levels and the clinical significance of angiostatin in DM patients receiving insulin. Materials and methods: This is a case-control study. Serum angiostatin levels were determined by ELISA. A total of 83 people consisting of healthy subjects (n = 36) and patients with a diagnosis of DM receiving insulin therapy (n = 47) were included in this study. Results: The mean angiostatin levels of the DM group were significantly higher than those of …
The Psychometric Evaluation Of The Turkish Version Of The Mann Assessment Of Swallowing Ability In Patients In The Early Period After Stroke, Ebru Karaca Umay, İbrahi̇m Gündoğdu, Eda Gürçay, Erhan Ari̇f Öztürk, Volkan Yilmaz, Özgür Zeli̇ha Karaahmet, Yasemi̇n Eren, Güleser Saylam, Fatma Aytül Çakci
The Psychometric Evaluation Of The Turkish Version Of The Mann Assessment Of Swallowing Ability In Patients In The Early Period After Stroke, Ebru Karaca Umay, İbrahi̇m Gündoğdu, Eda Gürçay, Erhan Ari̇f Öztürk, Volkan Yilmaz, Özgür Zeli̇ha Karaahmet, Yasemi̇n Eren, Güleser Saylam, Fatma Aytül Çakci
Turkish Journal of Medical Sciences
Background/aim: The Mann Assessment of Swallowing Ability (MASA) is an efficient tool that allows physicians to determine the alertness, cooperation, and respiration of patients, which are important factors when assessing swallowing . This study aimed to translate the MASA into Turkish (T-MASA) and to assess its reliability and validity in patients during the early period after a stroke . Materials and methods: The scale was administered to 141 patients in the early period after a stroke. For reliability, both internal consistency (Cronbach's alpha and corrected item-to-total correlations) and interrater reliability were analyzed. The procedures were scored by two blinded independent …
Investigation Of The Effect Of Combined Use Of Alloplastic-Based Tricalcium Phosphate Bone Graft And Antihemorrhagic Plant Extract (Abs) On Bone Regeneration In Surgically Induced Bone Defects In Nondiabetic Rats: An Experimental Animal Study, Abdulsamet Tani̇k, Arzum Güler Doğru, Veysi̇ Akpolat, Fi̇li̇z Acun Kaya, Ebru Saribaş, Mehmet Gül, Sevgi̇ İrtegün, Engi̇n Deveci̇
Investigation Of The Effect Of Combined Use Of Alloplastic-Based Tricalcium Phosphate Bone Graft And Antihemorrhagic Plant Extract (Abs) On Bone Regeneration In Surgically Induced Bone Defects In Nondiabetic Rats: An Experimental Animal Study, Abdulsamet Tani̇k, Arzum Güler Doğru, Veysi̇ Akpolat, Fi̇li̇z Acun Kaya, Ebru Saribaş, Mehmet Gül, Sevgi̇ İrtegün, Engi̇n Deveci̇
Turkish Journal of Medical Sciences
Background/aim: In this experimental study, we aimed to evaluate the late period effects of the combination of Ankaferd Blood Stopper (ABS), which has bone wound healing effects, and ß-tricalcium phosphate (TCP) on the regeneration of bone tissue through histopathological, immunohistochemical, and radiological (dual energy X-ray absorptiometry - DEXA) methods in nondiabetic rats. Materials and methods: Sixty-four Wistar albino male rats were used. In the calvaria of the rats, a bone defect 7.0 mm in diameter was created. These rats were divided into 4 different groups. Group 1 was the control group without any treatment, a 0.125 mL B-TCP graft was …
Synthesis, Biological Evaluation, And In Silico Study Of Some Unique Multifunctional 1,2,4-Triazole Acetamides, Almas Sattar, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Saddiqui, Shahid Rasool, Hira Khalid, Muhammad Arif Lodhi, Farman Ali Khan
Synthesis, Biological Evaluation, And In Silico Study Of Some Unique Multifunctional 1,2,4-Triazole Acetamides, Almas Sattar, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Saddiqui, Shahid Rasool, Hira Khalid, Muhammad Arif Lodhi, Farman Ali Khan
Turkish Journal of Chemistry
The imperative demand for antibacterial agents and enzyme inhibitors prompted us to synthesize some new compounds, 6a-6k, bearing multifunctional moieties. The target acetamides were derived from 4-phenyl-5-(1-tosylpiperidin-4-yl)-4$H$-1,2,4-triazole-3-thiol (3). The structural analysis was carried out using modern spectroscopic techniques including IR, NMR, and EIMS spectral analysis. The antibacterial activity was screened against five bacterial strains including three gram-negative and two gram-positive ones. Enzyme inhibition was carried out against lipoxygenase enzyme and results were supported by in silico study. The synthesized compounds were proved to be potent antibacterial agents and enzyme inhibitors.
Synthesis Of $E$-Stilbene Azomethines As Potent Antimicrobial And Antioxidant Agents, Ahsan Iqbal, Zulfiqar Ali Khan, Sohail Anjum Shahzad, Muhammad Usman, Shakeel Ahmad Khan, Abdul H. Fauq, Ayesha Bari, Muhammad Aamir Sajid
Synthesis Of $E$-Stilbene Azomethines As Potent Antimicrobial And Antioxidant Agents, Ahsan Iqbal, Zulfiqar Ali Khan, Sohail Anjum Shahzad, Muhammad Usman, Shakeel Ahmad Khan, Abdul H. Fauq, Ayesha Bari, Muhammad Aamir Sajid
Turkish Journal of Chemistry
A series of new extensively conjugated $E$-stilbene azomethines (5a-5h) were synthesized and screened for their antioxidant and antimicrobial activity. The compounds were tested against bacterial (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Bacillus subtilis) and fungal strains (Aspergillus niger, A. flavus, and Trichoderma harzianum) using the agar well diffusion method. Among the tested compounds, $N$'-(4-nitrobenzylidene)-2-(($E)$-styryl)benzohydrazide (5g) was found to possess potent antimicrobial activity higher than some drugs with significant activity reported in the literature, e.g., cefradine and terbinafine hydrochloride. Additionally, compounds 5a-5h were also evaluated for antioxidant potential using DPPH free radical scavenging and ferric thiocyanate (FTC) assays. Among these, …
An Ethnobotanical Survey In Selected Districts Of The Black Sea Region (Turkey), Emi̇ne Burcu Yeşi̇lyurt, Işil Şi̇mşek, Gali̇p Akaydin, Erdem Yeşi̇lada
An Ethnobotanical Survey In Selected Districts Of The Black Sea Region (Turkey), Emi̇ne Burcu Yeşi̇lyurt, Işil Şi̇mşek, Gali̇p Akaydin, Erdem Yeşi̇lada
Turkish Journal of Botany
The current study was carried out in selected districts of the Black Sea region of Turkey, in Trabzon (center), Çorum (İskilip town), Karabük (Yenice town), Amasya (Kapıkaya village), and Amasya (Belmebük village) in order to document the wild plants used by the local inhabitants, i.e. as a remedy or foodstuff or for other purposes. The data were collected from 352 individuals residing in these districts and volunteering to participate in the research through face-to-face interviewing. Depending on the data collected, the parts of the plants used, the purpose in using them, and the ways of preparation (simply cooking or decoction, …
Aftermath Of The Human Genome Project: An Era Of Struggle And Discovery, Zainab Hamdoun, Hashimul Ehsan
Aftermath Of The Human Genome Project: An Era Of Struggle And Discovery, Zainab Hamdoun, Hashimul Ehsan
Turkish Journal of Biology
The collaboration between the Human Genome Project and the Sanger Institute, spurred on by their contemporary- Celera Genomics, in the race to sequence the human genome, opened the door to a generation of research concerned with the study of the nucleic manual. Following this monumental achievement, the genomic era was born, heralding the development of gene therapy, personalized medicine, pharmacogenomics, and CRISPR/Cas9 gene-editing systems. These 'omic' disciplines offer a wide range of applications in the treatment of disease and the betterment of the quality of human life. Their notability, however, manifests in the unique mix of sociological and scientific discourse …
Pooled Analysis Of 899 Nosocomial Meningitis Episodes From Turkey, Oğuz Reşat Si̇pahi̇, Arzu Nazli Zeka, Meltem Taşbakan, Hüsnü Pullukçu, Bi̇lgi̇n Arda, Tansu Yamazhan, Hi̇lal Si̇pahi̇, Sercan Ulusoy
Pooled Analysis Of 899 Nosocomial Meningitis Episodes From Turkey, Oğuz Reşat Si̇pahi̇, Arzu Nazli Zeka, Meltem Taşbakan, Hüsnü Pullukçu, Bi̇lgi̇n Arda, Tansu Yamazhan, Hi̇lal Si̇pahi̇, Sercan Ulusoy
Turkish Journal of Medical Sciences
Background/aim: Healthcare-associated meningitis (HCAM) is a relatively rare entity with significant morbidity and mortality. The aim of this study was to systematically review the Turkish medical literature for acute nosocomial meningitis. Materials and methods: One national (ULAKBİM) and two international (www.scopus.com and www.pubmed.com) databases were searched. In addition, abstracts of four national congresses held between 2004 and 2013 were searched for reports for HCAM meningitis. Results: Data for 899 HCAM meningitis episodes were obtained from 24 reports. In terms of clinical findings, 177 of 216 (81.9%) had fever (>38 °C), 55 of 64 (85.9%) had high CRP levels, 105 …
Prevalence And Associated Factors Of Thrombocytopenia Among Human Immunodeficiency Virus-Infected Patients At A Tertiary Care Hospital In İzmir, Turkey, Can Hüseyi̇n Heki̇moğlu, Fi̇gen Kaptan, İlknur Vardar, Serap Ural, Nesri̇n Türker, Bahar Örmen, Nurbanu Sezak, Si̇bel El
Prevalence And Associated Factors Of Thrombocytopenia Among Human Immunodeficiency Virus-Infected Patients At A Tertiary Care Hospital In İzmir, Turkey, Can Hüseyi̇n Heki̇moğlu, Fi̇gen Kaptan, İlknur Vardar, Serap Ural, Nesri̇n Türker, Bahar Örmen, Nurbanu Sezak, Si̇bel El
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the prevalence and associated factors of thrombocytopenia in human immunodeficiency virus (HIV)-infected patients. Materials and methods: A cross-sectional study was conducted in a tertiary care hospital in İzmir, Turkey. All HIV-infected patients admitted to the Department of Infectious Diseases and Clinical Microbiology between 2006 and 2011 were recruited. Patients with thrombocytopenia at any time point were defined as the case group and the remaining patients were defined as the control group. Results: The frequency of thrombocytopenia was 35.8%. Thrombocytopenia was more frequent in patients with acquired immune deficiency syndrome (AIDS) than …
Nitric Oxide In Cerebrospinal Fluid Of Central Nervous System Tuberculosis: Correlations With Culture, Antibody Response, And Cell Count, Kavitha Kumar, Prashant Giribhattanavar, Shripad Patil
Nitric Oxide In Cerebrospinal Fluid Of Central Nervous System Tuberculosis: Correlations With Culture, Antibody Response, And Cell Count, Kavitha Kumar, Prashant Giribhattanavar, Shripad Patil
Turkish Journal of Medical Sciences
Background/aim: The role of nitric oxide (NO) has been established in infection over the years. NO functions by inhibiting the growth of intracellular pathogens. The present study was undertaken to ascertain the role of NO in central nervous system (CNS) infection by Mycobacterium tuberculosis. Materials and methods: A total of 781 chronic meningitis cerebrospinal fluid (CSF) samples suspected of CNS tuberculosis (TB) were categorized based on M. tuberculosis culture positivity, anti-TB antibody response, and CSF cell count and were analyzed for NO. Results: We found that NO levels were positive in 10.88% of the CSF samples. Positivity for NO was …
Epidemiology Of Under-Five Mortality In İstanbul: Changes From 1988 To 2011, Fahri̇ye Aysun Buzcu, Ayli̇n Yeti̇m Şahi̇n, Esra Karapinar, Özge Erol, Emi̇ne Gülbi̇n Gökçay
Epidemiology Of Under-Five Mortality In İstanbul: Changes From 1988 To 2011, Fahri̇ye Aysun Buzcu, Ayli̇n Yeti̇m Şahi̇n, Esra Karapinar, Özge Erol, Emi̇ne Gülbi̇n Gökçay
Turkish Journal of Medical Sciences
Background/aim: Understanding the causes of under-five deaths is key to realizing sustainable developmental goals. The aim of this descriptive study was to investigate the causes of under-five mortality in İstanbul during 2011 and compare the findings to those of 1988 and 2000. Materials and methods: All burial records of İstanbul were evaluated, and cemetery records of 1494 children, who died at under five years of age and were buried in İstanbul Metropolitan Municipality Cemeteries between 1 January and 31 December 2011, were analyzed. Several sociodemographic characteristics and causes of death were compared with the results of studies carried out in …
Analysis Of Epidemiology And Risk Factors For Mortality In Ventilator-Associated Pneumonia Attacks In Intensive Care Unit Patients, Ayşe But, Meltem Arzu Yetki̇n, Di̇lek Kanyilmaz, Hali̇de Aslaner, Ali̇ye Baştuğ, Adalet Aypak, Pinar Öngürü, Esragül Akinci, Nevzat Mehmet Mutlu, Hurrem Bodur
Analysis Of Epidemiology And Risk Factors For Mortality In Ventilator-Associated Pneumonia Attacks In Intensive Care Unit Patients, Ayşe But, Meltem Arzu Yetki̇n, Di̇lek Kanyilmaz, Hali̇de Aslaner, Ali̇ye Baştuğ, Adalet Aypak, Pinar Öngürü, Esragül Akinci, Nevzat Mehmet Mutlu, Hurrem Bodur
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the epidemiologic characteristics, the causative microorganisms and their antimicrobial susceptibility patterns, and the prognostic risk factors for mortality in critically ill patients with ventilator-associated pneumonia (VAP). Materials and methods: In this retrospective observational study, all the critically ill patients with VAP hospitalized in a medical/surgical intensive care unit (ICU) between January 2010 and June 2015 were evaluated. Patients' demographic features and microbiological data were reviewed. Results: A total of 417 patients were clinically diagnosed with VAP; 51.1% of them were male and the average age was found as 69.9 ± 15.9 …