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- COVID-19 (127)
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- Intensive care unit (11)
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- Molecular docking (10)
- Sheep (10)
- Staphylococcus aureus (10)
- Nosocomial infection (9)
- Publication Year
Articles 271 - 300 of 1022
Full-Text Articles in Entire DC Network
Hydroxychloroquine Plus Azithromycin And Early Hospital Admission Are Beneficial Incovid-19 Patients: Turkish Experience With Real-Life Data, Eli̇f Tanriverdi̇, Mustafa Çörtük, Bi̇nnaz Zeynep Yildirim, Efsun Gonca Uğur Chousein, Demet Turan, Hali̇t Çinarka, Mehmet Aki̇f Özgül, Erdoğan Çeti̇nkaya
Hydroxychloroquine Plus Azithromycin And Early Hospital Admission Are Beneficial Incovid-19 Patients: Turkish Experience With Real-Life Data, Eli̇f Tanriverdi̇, Mustafa Çörtük, Bi̇nnaz Zeynep Yildirim, Efsun Gonca Uğur Chousein, Demet Turan, Hali̇t Çinarka, Mehmet Aki̇f Özgül, Erdoğan Çeti̇nkaya
Turkish Journal of Medical Sciences
Background/aim: New treatment regimens for COVID-19, which has threatened the world recently, continue to be investigated. Although some of the treatments are promising, it is thought to be early to state that there is definitive treatment. Experiences and treatment protocol studies from treatment centers are still important. The aim of this study is to evaluate factors affecting the treatment process of the first cases followed in our clinic. Materials and methods: The consecutive hospitalized patients with COVID-19 pneumonia were analyzed in this retrospective and cross-sectional study. Data were recorded from the electronic and written files of patients. Results: Eighty-three patients …
Efficacy Of Convalescent Plasma According To Blood Groups In Covid-19 Patients, Tuba Hacibeki̇roğlu, Yasi̇n Kalpakçi, Ahmed Ci̇had Genç, İlhan Hacibeki̇roğlu, Cenk Sunu, Adem Saricaoğlu, Yakup Tomak, Oğuz Karabay, Mehmet Köroğlu
Efficacy Of Convalescent Plasma According To Blood Groups In Covid-19 Patients, Tuba Hacibeki̇roğlu, Yasi̇n Kalpakçi, Ahmed Ci̇had Genç, İlhan Hacibeki̇roğlu, Cenk Sunu, Adem Saricaoğlu, Yakup Tomak, Oğuz Karabay, Mehmet Köroğlu
Turkish Journal of Medical Sciences
Background/aim: In this study, we aim to investigate the efficacy of convalescent plasma (CP) according to blood groups (BGs) in the treatment of critically ill patients diagnosed with COVID-19. Materials and methods: Twenty-eight critically ill and laboratory-confirmed COVID-19 patients who were admitted to the intensive care unit (ICU) of Sakarya University, Medical Faculty were included in the study. Patients were divided into 2 groups: patients who received anti-A antibody (Ab) containing CP (BG O and B) and those who did not receive CP containing anti-A Ab (BG A and AB). Results: Among the 28 patients, 13 patients received anti-A Ab …
Projecting The Course Of Covid-19 In Turkey: A Probabilistic Modeling Approach, Aybar Can Acar, Ahmet Görkem Er, Hüseyi̇n Cahi̇t Burduroğlu, Seher Nur Sülkü, Yeşi̇m Aydin Son, Levent Akin, Serhat Ünal
Projecting The Course Of Covid-19 In Turkey: A Probabilistic Modeling Approach, Aybar Can Acar, Ahmet Görkem Er, Hüseyi̇n Cahi̇t Burduroğlu, Seher Nur Sülkü, Yeşi̇m Aydin Son, Levent Akin, Serhat Ünal
Turkish Journal of Medical Sciences
Background/aim: The COVID-19 pandemic originated in Wuhan, China, in December 2019 and became one of the worst global health crises ever. While struggling with the unknown nature of this novel coronavirus, many researchers and groups attempted to project the progress of the pandemic using empirical or mechanistic models, each one having its drawbacks. The first confirmed cases were announced early in March, and since then, serious containment measures have taken place in Turkey. Materials and methods: Here, we present a different approach, a Bayesian negative binomial multilevel model with mixed effects, for the projection of the COVID-19 pandemic and we …
The Investigation Of Adrenal Involvement In Carbapenem Resistant Acinetobacterbaumannii Sepsis: Experimental Mouse Model, Esma Eryilmaz Eren, Gökçen Di̇nç, Olgun Kontaş, Emi̇ne Alp Meşe, Mehmet Doğanay
The Investigation Of Adrenal Involvement In Carbapenem Resistant Acinetobacterbaumannii Sepsis: Experimental Mouse Model, Esma Eryilmaz Eren, Gökçen Di̇nç, Olgun Kontaş, Emi̇ne Alp Meşe, Mehmet Doğanay
Turkish Journal of Medical Sciences
Background/aim: In the last years, incidence of carbapenem resistant Acinetobacter baumannii sepsis is increasing with high mortality. However, it is not clear whether this is due to inadequate antimicrobial choice or a more severe clinical course. We aimed to evaluate the inflammation and adrenal involvement in the carbapenem resistant A. baumannii by using experimental mouse model sepsis. Materials and methods: Balb/c female mice were randomly put into control and three sepsis groups (A. baumannii susceptible to carbapenem-CSAB-, A. baumannii resistant to carbapenem-CRAB-, Escherichia coli). A total of sixty mice were included in this study with each group having 15 mice. …
Expression Profiles Of Interferon-Related Genes In Cells Infected With Influenza A Viruses Or Transiently Transfected With Plasmids Encoding Viral Rna Polymerase, Eli̇f Çağlayan, Kadi̇r Turan
Expression Profiles Of Interferon-Related Genes In Cells Infected With Influenza A Viruses Or Transiently Transfected With Plasmids Encoding Viral Rna Polymerase, Eli̇f Çağlayan, Kadi̇r Turan
Turkish Journal of Biology
Influenza A viruses frequently change their genetic characteristics, which leads to the emergence of new viruses. Consequently, elucidation of the relationship between influenza A virus and host cells has a great importance to cope with viral infections. In this study, it was aimed to determine expression profiles of interferon response genes in human embryonic kidney 293 (HEK293) cells infected with human (A/WSN-H1N1) and avian influenza A viruses (duck/Pennsylvania/10218/84/H5N2) or transfected with plasmids encoding viral RdRP subunits and, to obtain clues about the genes that may be important for the viral pathogenesis. The HEK293 cells cultured in a 12-well plate were …
Current Mutatome Of Sars-Cov-2 In Turkey Reveals Mutations Of Interest, Doğa Eski̇er, Evren Akalp, Özlem Dalan, Gökhan Karakülah, Yavuz Oktay
Current Mutatome Of Sars-Cov-2 In Turkey Reveals Mutations Of Interest, Doğa Eski̇er, Evren Akalp, Özlem Dalan, Gökhan Karakülah, Yavuz Oktay
Turkish Journal of Biology
As the underlying pathogen for the COVID-19 pandemic that has affected tens of millions of lives worldwide, SARS-CoV-2 and its mutations are among the most urgent research topics worldwide. Mutations in the virus genome can complicate attempts at accurate testing or developing a working treatment for the disease. Furthermore, because the virus uses its own proteins to replicate its genome, rather than host proteins, mutations in the replication proteins can have cascading effects on the mutation load of the virus genome. Due to the global, rapidly developing nature of the COVID-19 pandemic, local demographics of the virus can be difficult …
Prediction Of Host-Pathogen Protein Interactions By Extended Network Model, İrfan Kösesoy, Murat Gök, Tamer Kahveci̇
Prediction Of Host-Pathogen Protein Interactions By Extended Network Model, İrfan Kösesoy, Murat Gök, Tamer Kahveci̇
Turkish Journal of Biology
Knowledge of the pathogen-host interactions between the species is essentialin order to develop a solution strategy against infectious diseases. In vitro methods take extended periods of time to detect interactions and provide very few of the possible interaction pairs. Hence, modelling interactions between proteins has necessitated the development of computational methods. The main scope of this paper is integrating the known protein interactions between thehost and pathogen organisms to improve the prediction success rate of unknown pathogen-host interactions. Thus, the truepositive rate of the predictions was expected to increase.In order to perform this study extensively, encoding methods and learning algorithms …
A Deep Transfer Learning Based Model For Automatic Detection Of Covid-19from Chest X-Rays, Prateek Chhikara, Prakhar Gupta, Prabhjot Singh, Tarunpreet Bhatia
A Deep Transfer Learning Based Model For Automatic Detection Of Covid-19from Chest X-Rays, Prateek Chhikara, Prakhar Gupta, Prabhjot Singh, Tarunpreet Bhatia
Turkish Journal of Electrical Engineering and Computer Sciences
Deep learning in medical imaging has revolutionized the way we interpret medical data, as high computational devices' capabilities are far more than their creators. With the pandemic causing havoc for the second straight year, the findings in our paper will allow researchers worldwide to use and create state-of-the-art models to detect affected persons before it reaches the R number. The paper proposes an automated diagnostic tool using the deep learning models on chest x-rays as an input to reach a point where we surpass this pandemic (COVID-19 disease). A deep transfer learning-based model for automatic detection of COVID-19 from chest …
On The Local And Global Stability Of An Sirs Epidemic Model With Logistic Growth And Information Intervention, İrem Çay
Turkish Journal of Mathematics
In this study, we investigate an susceptible-infected-recovered-susceptible (SIRS) epidemic model with logistic growth and information intervention. Firstly, the basic reproduction number $R_0$ is defined and the main results are given in terms of local stability. Then, sufficient conditions for the global stability of endemic equilibrium are obtained. Finally, some numerical simulations are given to validate our theoretical conclusions.
On The Spectral And Scattering Properties Of Eigenparameter Dependent Discrete Impulsive Sturm-Liouville Equations, Yelda Aygar Küçükevci̇li̇oğlu, Elgi̇z Bayram, Güher Gülçehre Özbey
On The Spectral And Scattering Properties Of Eigenparameter Dependent Discrete Impulsive Sturm-Liouville Equations, Yelda Aygar Küçükevci̇li̇oğlu, Elgi̇z Bayram, Güher Gülçehre Özbey
Turkish Journal of Mathematics
This work develops scattering and spectral analysis of a discrete impulsive Sturm-Liouville equation with spectral parameter in boundary condition. Giving the Jost solution and scattering solutions of this problem, we find scattering function of the problem. Discussing the properties of scattering function, scattering solutions, and asymptotic behavior of the Jost solution, we find the Green function, resolvent operator, continuous and point spectrum of the problem. Finally, we give an example in which the main results are made explicit.
Anti-Mycobacterial Activity And Chemical Composition Of Essential Oils And Phenolicextracts Of The Balsam Of Liquidambar Orientalis Mill. (Altingiaceae), Tüli̇n Aşkun, Mi̇ne Kürkçüoğlu, Pinar Güner
Anti-Mycobacterial Activity And Chemical Composition Of Essential Oils And Phenolicextracts Of The Balsam Of Liquidambar Orientalis Mill. (Altingiaceae), Tüli̇n Aşkun, Mi̇ne Kürkçüoğlu, Pinar Güner
Turkish Journal of Botany
Liquidambar orientalis Mill. (Altingiaceae) is known in Turkish as 'sığla' or ,'günlük' due to its gum-like exudate. Its exudate, `balsam of Liquidambar? (BL), is of great commercial importance because it has pharmaceutical properties and is rich in essential oils and phenolics. In this study, we investigated the phenolic profile of L. orientalis. using HPLC, and 5 compounds from BL-1, (juglone, naringenin, rosmarinic acid, vanillic acid, echinacoside) and 4 compounds from BL-2 (juglone, apigenin-7-glucoside, naringenin, vanillic acid) were reported for the first time. A total of six new flavonoids (juglone, naringenin, rosmarinic acid, echinacoside, vanillic acid, and apigenin-7-glucoside) were identified from …
Applications Of Crispr/Cas9-Based Genome Editing In The Plant Biology, Yingzhuan Zheng, Qianqian Li, Mingwang Ye, Aie Cehn, Hongyang Wang
Applications Of Crispr/Cas9-Based Genome Editing In The Plant Biology, Yingzhuan Zheng, Qianqian Li, Mingwang Ye, Aie Cehn, Hongyang Wang
Turkish Journal of Botany
Clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins (CRISPR/Cas) is an acquired immune system found in bacteria and archaea that can specifically silence or degrade a foreign single or double strand nucleic acid to protect it from infection. In recent years, the CRISPR/Cas9 system has rapidly been evolved into a genome editing technology, in which the Cas9 endonuclease can be targeted to specific DNA sequences by guide RNAs (gRNAs) that are easily programmable. Due to simplicity, specificity and high efficiency, CRISPR/Cas9 is gradually replacing other gene editing technologies and has been implemented in basic and applied plant sciences to boost yield, …
The Effect Of Weekend Curfews On Epidemics: A Monte Carlo Simulation, Hakan Kaygusuz, Ahmet Ni̇hat Berker
The Effect Of Weekend Curfews On Epidemics: A Monte Carlo Simulation, Hakan Kaygusuz, Ahmet Ni̇hat Berker
Turkish Journal of Biology
The ongoing COVID-19 pandemic is being responded with various methods, applying vaccines, experimental treatment options, total lockdowns or partial curfews. Weekend curfews are among the methods for reducing the number of infected persons, and this method is practically applied in some countries such as Turkey. In this study, the effect of weekend curfews on reducing the spread of a contagious disease, such as COVID-19, is modeled using a Monte Carlo algorithm with a hybrid lattice model. In the simulation setup, a fictional country with three towns and 26,610 citizens were used as a model. Results indicate that applying a weekend …
Binary-Qsar Guided Virtual Screening Of Fda Approved Drugs And Compounds In Clinical Investigation Against Sars-Cov-2 Main Protease, Lalehan Oktay, Ece Erdemoğlu, İlayda Tolu, Yeşi̇m Yumak, Ayşenur Özcan, Eli̇f Acar, Şehri̇ban Büyükkiliç, Alpsu Olkan, Serdar Durdaği
Binary-Qsar Guided Virtual Screening Of Fda Approved Drugs And Compounds In Clinical Investigation Against Sars-Cov-2 Main Protease, Lalehan Oktay, Ece Erdemoğlu, İlayda Tolu, Yeşi̇m Yumak, Ayşenur Özcan, Eli̇f Acar, Şehri̇ban Büyükkiliç, Alpsu Olkan, Serdar Durdaği
Turkish Journal of Biology
With the emergence of the new SARS-CoV-2 virus, drug repurposing studies have gained substantial importance. Combined with the efficacy of recent improvements in ligand- and target-based virtual screening approaches, virtual screening has become faster and more productive than ever. In the current study, an FDA library of approved drugs and compounds under clinical investigation were screened for their antiviral activity using the antiviral therapeutic activity binary QSAR model of the MetaCore/MetaDrug platform. Among 6733-compound collection, we found 370 compounds with a normalized therapeutic activity value greater than a cutoff of 0.75. Only these selected compounds were used for molecular docking …
The Current State Of Validated Small Molecules Inhibiting Sars-Cov-2 Non-Structural Proteins, Fati̇h Kocabaş, Merve Uslu
The Current State Of Validated Small Molecules Inhibiting Sars-Cov-2 Non-Structural Proteins, Fati̇h Kocabaş, Merve Uslu
Turkish Journal of Biology
The current COVID-19 outbreak has had a profound influence on public health and daily life. Despite all restrictions and vaccination programs, COVID-19 still can lead to fatality due to a lack of COVID-19-specific treatments. A number of studies have demonstrated the feasibility to develop therapeutics by targeting underlying components of the viral proteome. Here we reviewed recently developed and validated small molecule inhibitors of SARS-CoV-2's nonstructural proteins. We described the validation level of identified compounds specific for SARS-CoV-2 in the presence of in vitro and in vivo supporting data. The mechanisms of pharmacological activity, as well as approaches for developing …
Coronavac (Sinovac) Covid-19 Vaccine-Induced Molecular Changes In Healthy Human Serum By Infrared Spectroscopy Coupled With Chemometrics, Ayça Doğan Mollaoğlu, Rafi̇g Gurbanov, Mete Severcan, Feri̇de Severcan
Coronavac (Sinovac) Covid-19 Vaccine-Induced Molecular Changes In Healthy Human Serum By Infrared Spectroscopy Coupled With Chemometrics, Ayça Doğan Mollaoğlu, Rafi̇g Gurbanov, Mete Severcan, Feri̇de Severcan
Turkish Journal of Biology
From the beginning of the COVID-19 coronavirus pandemic in December of 2019, the disease has infected millions of people worldwide and caused hundreds of thousands of deaths. Since then, several vaccines have been developed. One of those vaccines is inactivated CoronaVac-Sinovac COVID-19 vaccine. In this proof of concept study, we first aimed to determine CoronaVac-induced biomolecular changes in healthy human serum using infrared spectroscopy. Our second aim was to see whether the vaccinated group can be separated or not from the non-vaccinated group by applying chemometric techniques to spectral data. The results revealed that the vaccine administration induced significant changes …
Analysis Of Designs Used In Monitoring Crop Growth Based On Remote Sensing Methods, Cristina Teodora Dobrota, Rahela Carpa, Anca Butiuc-Keul
Analysis Of Designs Used In Monitoring Crop Growth Based On Remote Sensing Methods, Cristina Teodora Dobrota, Rahela Carpa, Anca Butiuc-Keul
Turkish Journal of Agriculture and Forestry
Choosing appropriate designs and methods for monitoring crop growth is a challenging process of major importance. Remote sensing from space and manned or unmanned airborne operations are used to measure crop reflectance and a wide variety of other agricultural parameters. While some experiments use only a few, specific methods and designs and organize the results in lists of evidence, other experiments use a wider range of techniques to create a more credible and comprehensive assessment of crop yield. Particular situations related to the available resources in terms of data collection and expertise in addition to the intended use of the …
Treatment Of Sars-Cov-2 Pneumonia With Favipiravir: Early Results From The Egeuniversity Cohort, Turkey, Hüseyi̇n Aytaç Erdem, Pervi̇n Korkmaz Ekren, Derya Çağlayan, Meltem Taşbakan, Tansu Yamazhan, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Ayşe Deni̇z Gökengi̇n
Treatment Of Sars-Cov-2 Pneumonia With Favipiravir: Early Results From The Egeuniversity Cohort, Turkey, Hüseyi̇n Aytaç Erdem, Pervi̇n Korkmaz Ekren, Derya Çağlayan, Meltem Taşbakan, Tansu Yamazhan, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Ayşe Deni̇z Gökengi̇n
Turkish Journal of Medical Sciences
Background/aim: The aim of this descriptive article is to share the experience in Ege University, Turkey with favipiravir in the treatment of severe SARS-CoV-2 pneumonia. Materials and methods: This retrospective descriptive study included patients diagnosed with COVID-19 who presented with or developed severe pneumonia. Results: Forty patients who completed a full course (at least 5 days) of favipiravir were included in the study. At baseline, 30 (75%) patients required treatment for respiratory distress. Thirty-three patients (82.5%) were discharged from the hospital with full recovery, 6 patients (15%) died and 1 case (2.5%) was still at the intensive care unit (ICU) …
Lack Of Awareness Of Hepatitis B Screening And Vaccination In High-Risk Groups, Hati̇ce Yasemi̇n Balaban, Abdullah Tarik Aslan, Şefi̇ka Nur Ayar, Osman Dağ, Alpaslan Alp, Cem Şi̇mşek, Cavanşi̇r Vahabov, Tolga Yildirim, Hakan Göker, Yahya Büyükaşik, Hali̇s Şi̇mşek
Lack Of Awareness Of Hepatitis B Screening And Vaccination In High-Risk Groups, Hati̇ce Yasemi̇n Balaban, Abdullah Tarik Aslan, Şefi̇ka Nur Ayar, Osman Dağ, Alpaslan Alp, Cem Şi̇mşek, Cavanşi̇r Vahabov, Tolga Yildirim, Hakan Göker, Yahya Büyükaşik, Hali̇s Şi̇mşek
Turkish Journal of Medical Sciences
Background/aim: Hepatitis B virus (HBV) vaccination rates are insufficient in high-risk patients worldwide. This study aimed to investigate the screening, immunization, and vaccination rates in three high-risk groups for HBV infection: allogeneic hematopoietic stem cell transplantation (AHSCT), renal transplantation (RT), and chronic hepatitis C (CHC) groups. Materials and methods: The serological data of consecutive patients between 2014 and 2019 were reviewed using the hospital database. Results: The HBV screening rates were 100.0%, 90.4%, and 82.4% in the AHSCT, CHC, and RT groups, respectively (p = 0.003). The immunization rates against HBV through either previous exposure or vaccination were 79.5%, 71.7%, …
Which Hematological Markers Have Predictive Value As Early Indicators Of Severecovid-19 Cases In The Emergency Department?, İshak Şan, Emi̇n Gemci̇oğlu, Mehmet Davutoğlu, Rami̇s Çatalbaş, Berkan Karabuğa, Enes Kaptan, Abdulsamet Erden, Orhan Küçükşahi̇n, İhsan Ateş, Selma Karaahmetoğlu, İmran Hasanoğlu, Osman İnan, Büşra Nur Ünal, Ecem Erdemi̇r, Fati̇h Ahmet Kahraman
Which Hematological Markers Have Predictive Value As Early Indicators Of Severecovid-19 Cases In The Emergency Department?, İshak Şan, Emi̇n Gemci̇oğlu, Mehmet Davutoğlu, Rami̇s Çatalbaş, Berkan Karabuğa, Enes Kaptan, Abdulsamet Erden, Orhan Küçükşahi̇n, İhsan Ateş, Selma Karaahmetoğlu, İmran Hasanoğlu, Osman İnan, Büşra Nur Ünal, Ecem Erdemi̇r, Fati̇h Ahmet Kahraman
Turkish Journal of Medical Sciences
Background/aim: Coronavirus 2019 disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic infectious disease that causes morbidity and mortality. As a result of high mortality rate among the severe COVID-19 patients, the early detection of the disease stage and early effective interventions are very important in reducing mortality. Hence, it is important to differentiate severe and nonsevere cases from each other. To date, there are no proven diagnostic or prognostic parameters that can be used in this manner. Due to the expensive and not easily accessible tests that are performed for COVID-19, researchers are investigating …
Correlation Of Neuroimaging And Thorax Ct Findings In Patients With Covid-19:A Large Single-Center Experience, Hedi̇ye Pinar Günbey, Günay Rona, Özge Adigüzel Karaoysal, Ayşe Batirel, Banu Özen Barut
Correlation Of Neuroimaging And Thorax Ct Findings In Patients With Covid-19:A Large Single-Center Experience, Hedi̇ye Pinar Günbey, Günay Rona, Özge Adigüzel Karaoysal, Ayşe Batirel, Banu Özen Barut
Turkish Journal of Medical Sciences
Background/aim: The aim of this current study was to describe the neuroimaging findings among patients with COVID-19 and to compare them with thorax CT imaging findings and clinicobiological profiles. Materials and methods: Between the period March 11 and December 31, 2020, we evaluated brain computed tomography (CT) and magnetic resonance (MR) images of patients with COVID-19. A total of 354 patients (mean age 65.2 ± 16.6, 52% female, 42% male) who had brain imaging were included in the study. Of this total sample, 218 had thorax CT scanning (65.5%). Neuroimaging and thorax CT findings, clinical course, neurologic findings, and laboratory …
Decrease Of Left Ventricular Ejection Fraction In Severe Illness Patients Due To Covid-19may Improve As The Disease Resolves, Aykut Demi̇rkiran, Lütfi̇ Çağatay Onar, Mustafa Doğan
Decrease Of Left Ventricular Ejection Fraction In Severe Illness Patients Due To Covid-19may Improve As The Disease Resolves, Aykut Demi̇rkiran, Lütfi̇ Çağatay Onar, Mustafa Doğan
Turkish Journal of Medical Sciences
Background/aim: Increase in publications supporting myocardial involvement in the COVID-19 disease has led to need to gain insight into the the global burden of heart failure after pandemic. We examined the course of myocardial systolic function in patients without elevated troponin levels. Materials and methods: We performed a prospective study. Patients with high troponin levels were excluded from the study in order to definitively exclude complications known to cause permanent left ventricular systolic dysfunction, such as acute coronary syndromes. Two echocardiographic examinations were performed. The first evaluation was performed within the days of hospitalization, if possible, on the day when …
Influenza And Pneumococcus Vaccination Rates In Pediatric Dialysis Patients Ineurope: Recommendations Vs Realitya European Pediatric Dialysis Working Group And European Society For Pediatricnephrology Dialysis Working Group Study, Yeşi̇m Özdemi̇r Ati̇kel, Sevcan Azi̇me Bakkaloğlu Ezgü, Fabio Paglialonga, Constantinos J. Stefanidis, Varvara Askiti, Enrico Vidal, Gema Ariceta, Engi̇n Melek, Enrico Verrina, Nikoleta Printza, Karel Vondrak, Aleksandra Zurowska, Ilona Zagozdzon, Mesi̇ha Eki̇m, Eli̇f Nursel Özmert
Influenza And Pneumococcus Vaccination Rates In Pediatric Dialysis Patients Ineurope: Recommendations Vs Realitya European Pediatric Dialysis Working Group And European Society For Pediatricnephrology Dialysis Working Group Study, Yeşi̇m Özdemi̇r Ati̇kel, Sevcan Azi̇me Bakkaloğlu Ezgü, Fabio Paglialonga, Constantinos J. Stefanidis, Varvara Askiti, Enrico Vidal, Gema Ariceta, Engi̇n Melek, Enrico Verrina, Nikoleta Printza, Karel Vondrak, Aleksandra Zurowska, Ilona Zagozdzon, Mesi̇ha Eki̇m, Eli̇f Nursel Özmert
Turkish Journal of Medical Sciences
Background/aim: Children on dialysis are under increased risk of influenza and invasive pneumococcal disease. Although vaccination against these microorganisms are recommended in dialysis patients and despite the fact that these vaccines can reduce disease burden and rates of hospitalization due to infection, vaccination rates are below expected and desired. We aimed to evaluate influenza and pneumococcal vaccination and infection rates in European pediatric dialysis centers. Materials and methods: In 16 centers from 11 countries, 357 pediatric dialysis patients were evaluated retrospectively during 1 year of observation period between 01.01.2014 and 01.01.2015. Results: In all centers, vaccination policy included immunization of …
Can Thrombocytosis Or Thrombocytopenia Predict Complicated Clinical Course And30-Days Mortality In Patients With Pneumonia?, Razi̇ye Si̇nem Misirlioğlu, Ersi̇n Aksay, Emre Şanci, Kemal Can Tertemi̇z
Can Thrombocytosis Or Thrombocytopenia Predict Complicated Clinical Course And30-Days Mortality In Patients With Pneumonia?, Razi̇ye Si̇nem Misirlioğlu, Ersi̇n Aksay, Emre Şanci, Kemal Can Tertemi̇z
Turkish Journal of Medical Sciences
Background/aim: While several different scoring systems aim to determine the clinical outcomes for patients with pneumonia, there is limited emphasis on the platelet count. This study investigated the relationships between thrombocyte count and 30-day mortality and complicated clinical course of patients with pneumonia. Materials and methods: This prospective cross-sectional study enrolled patients over 18 years old with a diagnosis of pneumonia in the emergency department for six months. The primary outcome was to establish the relationship between platelet count, mortality, complicated clinical course, and initial vital parameters on admission. The secondary outcome was comparing the platelet count with mortality and …
Risk Of Tuberculosis Is Increased In Behçet's Disease Compared To Other Rheumatologicaldisorders After Anti-Tnf∝ Treatments: A Case Series And Review Of The Literature, Ümmügülsüm Gazel, Derya Kocakaya, İrem Hi̇cret Topçu, Hakan Ömer Karataş, Murat Karabacak, Mehmet Pami̇r Atagündüz, Güzi̇de Nevsun İnanç, Fatma Ali̇baz Öner, Rafi̇ Haner Di̇reskeneli̇
Risk Of Tuberculosis Is Increased In Behçet's Disease Compared To Other Rheumatologicaldisorders After Anti-Tnf∝ Treatments: A Case Series And Review Of The Literature, Ümmügülsüm Gazel, Derya Kocakaya, İrem Hi̇cret Topçu, Hakan Ömer Karataş, Murat Karabacak, Mehmet Pami̇r Atagündüz, Güzi̇de Nevsun İnanç, Fatma Ali̇baz Öner, Rafi̇ Haner Di̇reskeneli̇
Turkish Journal of Medical Sciences
Background/aim: Tumor necrosis factor-alfa (TNF-a) antagonists are extensively utilized in the treatment of inflammatory rheumatic diseases and also shown to be effective in Behçet's disease (BD) patients with major organ involvement. In this study, we aimed to reevaluate the incidence of tuberculosis (TB) infection after anti-TNFa treatments and to reveal the risk of TB in BD. Methods: Data of patients who received anti-TNFa treatment between 2005 and 2018 were assessed retrospectively. Demographic features, TNF-a antagonist type/treatment time, tuberculosis skin test (TST) and QuantiFERON results, isoniazid prophylaxis status, and concomitant corticosteroid (CS) treatments were collected. Results: A total of 1277 (male/female …
Evaluation Of Extensively Drug-Resistant Gram-Negative Bacteremia Among Solid-Organtransplant Recipients: A Multicenter Study, Tuğba Yanik Yalçin, Özlem Azap, Adem Köse, Yaşar Bayindir, Eli̇f Muki̇me Saricaoğlu, Güle Çinar, Yeşi̇m Uygun Kizmaz, Ebru Kurşun, Hi̇kmet Eda Alişkan, Ayşe Yasemi̇n Tezer Tekçe, Oya Özlem Eren Kutsoylu, Tufan Egeli̇, Alpay Ari, Yurdagül Albayrak, Hati̇ce Çabadak
Evaluation Of Extensively Drug-Resistant Gram-Negative Bacteremia Among Solid-Organtransplant Recipients: A Multicenter Study, Tuğba Yanik Yalçin, Özlem Azap, Adem Köse, Yaşar Bayindir, Eli̇f Muki̇me Saricaoğlu, Güle Çinar, Yeşi̇m Uygun Kizmaz, Ebru Kurşun, Hi̇kmet Eda Alişkan, Ayşe Yasemi̇n Tezer Tekçe, Oya Özlem Eren Kutsoylu, Tufan Egeli̇, Alpay Ari, Yurdagül Albayrak, Hati̇ce Çabadak
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to evaluate the distribution, sources, clinical features, and mortality rates of bacteremia due to evaluation of extensively drug-resistant (XDR) gram negative among solid-organ transplant (SOT) recipients. Materials and methods: A retrospective study of SOT recipients with bacteremia due to XDR gram-negative pathogens in 11 centers between 2016 and 2018 was conducted. Patients' records were evaluated. Results: Of 171 bacteremia that occurred in 164 SOT recipients, 93 (56.7%) were liver, 46 (28%) kidney, 14 (8.5%) heart, and 11 (6.7%) lung recipients. Bacteremia episodes were recorded in the first year in 63.7% of the patients …
Circulating Mir-29c-3p Is Downregulated In Patients With Acromegaly, Hakan Korkmaz, Kuyaş Heki̇mler Öztürk, Bora Torus
Circulating Mir-29c-3p Is Downregulated In Patients With Acromegaly, Hakan Korkmaz, Kuyaş Heki̇mler Öztürk, Bora Torus
Turkish Journal of Medical Sciences
Background/aim: miRNAs control various biological functions, such as cell proliferation, differentiation, signaling pathways, apoptosis and metabolism. Recently, it has been shown that there is a relationship between changes in miRNA expression and the development of acromegaly. Studies are needed to identify new disease-specific miRNAs. The aim of the current study is to evaluate plasma miR-29c-3p, miR-31-5p and miR-18a-5p steady-state levels in acromegaly. Another aim is to investigate whether there is a difference in the levels of these miRNAs in patients with inadequate control and controlled acromegaly with somatostatin analog (SSA) therapy. These miRNAs targeting the IGF-1 gene were determined by …
Allergic Reactions Against Covıd-19 Vaccines, Hi̇lal Ünsal, Bülent Eni̇s Şekerel, Ümi̇t Murat Şahi̇ner
Allergic Reactions Against Covıd-19 Vaccines, Hi̇lal Ünsal, Bülent Eni̇s Şekerel, Ümi̇t Murat Şahi̇ner
Turkish Journal of Medical Sciences
Coronavirus Disease 2019 (COVID-19) affected the whole world in a short time. One of the most influential public health initiatives modern medicine has to offer, the vaccine has become even more important as the COVID-19 pandemic continues to worsen worldwide. Many vaccine trials were launched during the COVID-19 pandemic, and these vaccines were widely used around the world, offering realistic hope for ending the pandemic. Allergic reactions to vaccines were reported shortly after their approval. These reactions, in general, are rare, but, in some circumstances, they can be serious. Allergy to vaccines can occur because of either the active vaccine …
High Mobility Group Box-1 Levels May Be Associated With Disease Activity Of Behcet's Disease, Di̇lara Dönmez Güler, Ayşe Bahar Keleşoğlu Di̇nçer, Zeynep Ceren Karahan, Hasan Seli̇m Güler, Müçteba Enes Yayla, Serdar Sezer, Emi̇ne Gözde Aydemi̇r Gülöksüz, İlyas Ercan Okatan, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Mehmet Levent Yüksel, Tahsi̇n Murat Turğay, Gülay Kinikli, Aşkin Ateş
High Mobility Group Box-1 Levels May Be Associated With Disease Activity Of Behcet's Disease, Di̇lara Dönmez Güler, Ayşe Bahar Keleşoğlu Di̇nçer, Zeynep Ceren Karahan, Hasan Seli̇m Güler, Müçteba Enes Yayla, Serdar Sezer, Emi̇ne Gözde Aydemi̇r Gülöksüz, İlyas Ercan Okatan, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Mehmet Levent Yüksel, Tahsi̇n Murat Turğay, Gülay Kinikli, Aşkin Ateş
Turkish Journal of Medical Sciences
Background/aim: High mobility group box- 1 (HMGB- 1) is a nuclear protein acting as a proinflammatory molecule. The serum HMGB- 1 levels were found elevated in chronic inflammatory diseases. In this cross-sectional study, serum HMGB- 1 levels in Behcet's disease (BD) patients and healthy controls (HC) were studied. Also, its association with disease activity scores and clinical findings were evaluated. Materials and methods: Ninety BD patients and 50 age-sex matched HC were included in the study. Disease activity scores were assessed by Behcet Disease Current Activity Form (BDCAF) and Behcet Syndrome Activity Score (BSAS). Serum HMGB- 1 levels were measured …
Pretreatment Serum Uric Acid Level Is Not A Surrogate Marker For The Outcome Offavipiravir Treatment In Covid-19 Patients, Ahmet Çağkan İnkaya, Emre Kara, Nursel Çalik Başaran, Taha Koray Şahi̇n, Oğuz Abdullah Uyaroğlu, Ömrüm Uzun, Serhat Ünal
Pretreatment Serum Uric Acid Level Is Not A Surrogate Marker For The Outcome Offavipiravir Treatment In Covid-19 Patients, Ahmet Çağkan İnkaya, Emre Kara, Nursel Çalik Başaran, Taha Koray Şahi̇n, Oğuz Abdullah Uyaroğlu, Ömrüm Uzun, Serhat Ünal
Turkish Journal of Medical Sciences
No abstract provided.