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- COVID-19 (127)
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- Molecular docking (10)
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Articles 241 - 270 of 1022
Full-Text Articles in Entire DC Network
Factors Affecting Mortality In Geriatric Patients Hospitalized With Covid-19, Rabi̇a Bağ Soytaş, Damla Ünal, Pinar Arman, Veysel Suzan, Tuğçe Emi̇roğlu Gedi̇k, Günay Can, Bora Korkmazer, Ridvan Karaali̇, Şermi̇n Börekçi̇, Mert Ahmet Kuşkucu, Hakan Yavuzer, Ülev Deni̇z Erdi̇nçler, Alper Döventaş
Factors Affecting Mortality In Geriatric Patients Hospitalized With Covid-19, Rabi̇a Bağ Soytaş, Damla Ünal, Pinar Arman, Veysel Suzan, Tuğçe Emi̇roğlu Gedi̇k, Günay Can, Bora Korkmazer, Ridvan Karaali̇, Şermi̇n Börekçi̇, Mert Ahmet Kuşkucu, Hakan Yavuzer, Ülev Deni̇z Erdi̇nçler, Alper Döventaş
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate the factors affecting the mortality of patients aged 65 years or older who were hospitalized with the diagnosis of new coronavirus pneumonia (COVID-19). Materials and methods: This is a retrospective study of patients 65 years old or older with COVID-19 who were hospitalized in İstanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty Hospital, between March 11 and May 28, 2020. Demographic, clinical, treatment, and laboratory data were extracted from electronic medical records. We used univariate and multivariate logistic regression methods to explore the risk factors for in-hospital death. Results: A total of 218 patients (112 men, 106 women) …
The Necessity Of Treating Asymptomatic Bacteriuria With Antibiotics In The Perioperativeperiod Of Joint Arthroplasty: A Metaanalysis., Sayed Abdulla Jami, Jian Dang Shi, Zhanwen Zhou, Chang Hao Liu
The Necessity Of Treating Asymptomatic Bacteriuria With Antibiotics In The Perioperativeperiod Of Joint Arthroplasty: A Metaanalysis., Sayed Abdulla Jami, Jian Dang Shi, Zhanwen Zhou, Chang Hao Liu
Turkish Journal of Medical Sciences
Background/aim: Oral antibiotics are usually used to treat asymptomatic bacteriuria during the perioperative period of joint replacement. However, there is no unified conclusion as to whether asymptomatic bacteriuria causes infection around joint prostheses, and the efficacy of antibiotics is unknown. Materials and methods: We systematically searched PubMed, CNKI, Ovid, Cochrane Library, EMBASE, manual research, and references of relevant articles up to January 1, 2020, to identify and compare observational studies. The Cochrane systematic review method was used, and Review Manager 5.3 software was used for analysis. Results: Nine articles were included in the analysis, involving 29,844 cases of joint arthroplasty …
Acute Necrotizing Encephalopathy Of Childhood: A Single-Center Experience, Erhan Aksoy, Ülkühan Öztoprak, Hali̇l Çeli̇k, Fati̇h Mehmet Aki̇f Özdemi̇r, Mehbare Özkan, Hülya Kayilioğlu, Ayşegül Daniş, Özge Kucur, Selman Kesi̇ci̇, Mutlu Uysal Yazici, Ebru Azapağasi, Yasemi̇n Taşci Yildiz, Nesri̇n Ceylan, Sali̇ha Şenel, Deni̇z Yüksel
Acute Necrotizing Encephalopathy Of Childhood: A Single-Center Experience, Erhan Aksoy, Ülkühan Öztoprak, Hali̇l Çeli̇k, Fati̇h Mehmet Aki̇f Özdemi̇r, Mehbare Özkan, Hülya Kayilioğlu, Ayşegül Daniş, Özge Kucur, Selman Kesi̇ci̇, Mutlu Uysal Yazici, Ebru Azapağasi, Yasemi̇n Taşci Yildiz, Nesri̇n Ceylan, Sali̇ha Şenel, Deni̇z Yüksel
Turkish Journal of Medical Sciences
Background/aim: Acute necrotizing encephalopathy is a rare type of acute encephalopathy characterized by multi-ocal brain lesions and associated severe neurological findings and various organ dysfunctions may accompany it. Materials and Methods: Patients with acute necrotizing encephalopathy of childhood diagnosed by pediatric neurology and pediatric intensive care at Sami Ulus Maternity, Child Health and Diseases Training and Research Hospital between 2007 and 2020 were included in this study. Results: Nine patients (six females, three males) with a mean age of 4.05 ± 1.94 years (age range 1-6.5) were included in this study. The interval range between fever and encephalopathy in patients …
Umbilical Cord Levels Of Macrophage Migration Inhibitory Factor In Neonatal Respiratorydistress Syndrome, Süleyman Bayraktar, Bi̇lge Bayraktar, Ülkan Kiliç
Umbilical Cord Levels Of Macrophage Migration Inhibitory Factor In Neonatal Respiratorydistress Syndrome, Süleyman Bayraktar, Bi̇lge Bayraktar, Ülkan Kiliç
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the association of the umbilical cord macrophage migration inhibitory factor (MIF) with the respiratory distress syndrome (RDS) in preterm infants. Materials and methods: A total of eighty six preterm infants (38 with RDS and 48 without RDS) were involved in the study. ELISA is the technique assaying MIF values. Results: The mean of the infants' gestational ages and birth weights were significantly different (P = 0.0001). There were no significant differences in sex, delivery mode or exposure to antenatal steroid among the groups (P > 0.05). Umbilical cord MIF levels of the infants were not correlated …
Achievements Of The Covid-19 Turkey Platform In Vaccine And Drug Development Withan Approach Of "Co-Creation And Succeeding Together", Hasan Mandal
Turkish Journal of Medical Sciences
Mobilizing the research ecosystem for accelerating vaccine and drug development has been an important reality of the pandemic. This article reviews the scientific advances that are attained by the COVID-19 Turkey Platform for vaccine and drug development against the SARS-CoV-2 virus. The platform that is coordinated by the Scientific and Technological Research Council of Turkey is established with a "co-creation and succeeding together" approach, which involves 436 researchers across 49 different institutions working on 17 vaccine and drug development projects in total. Recent advances of the COVID-19 Turkey Platform include the fourth virus-like particle-based vaccine candidate in the world to …
Turkey's Response To Covid-19 Pandemic: Strategy And Key Actions, Gülşen Barlas, Harun Öztürk, Gülen Pehli̇vantürk, Sabahatti̇n Aydin
Turkey's Response To Covid-19 Pandemic: Strategy And Key Actions, Gülşen Barlas, Harun Öztürk, Gülen Pehli̇vantürk, Sabahatti̇n Aydin
Turkish Journal of Medical Sciences
COVID-19 emerged at the end of 2019 in Wuhan, China, and spread rapidly around the world causing many deaths. Due to the intercontinental escalation in the epidemic, while WHO declared a pandemic on March 11, 2020, our country's first case was diagnosed. Before this, the MoH established the Operations Center against possible risks regarding the Pandemic Influenza Preparedness Plan on January 10, 2020 and formed the Scientific Committee, which has a critical importance in epidemic management. National and Provincial Pandemic Coordination Boards were established within the scope of this plan. Fast, effective and frequently updated decisions were implemented. The epidemic …
One And A Half Years Into The Covid-19 Pandemic - Exit Strategies And Efficacy Of Sarscov-2 Vaccines For Holistic Management And Achieving Global Control, Eskild Petersen, Ayşe Deni̇z Gökengi̇n, Asma Al Balushi, Alimuddin Zumla
One And A Half Years Into The Covid-19 Pandemic - Exit Strategies And Efficacy Of Sarscov-2 Vaccines For Holistic Management And Achieving Global Control, Eskild Petersen, Ayşe Deni̇z Gökengi̇n, Asma Al Balushi, Alimuddin Zumla
Turkish Journal of Medical Sciences
One and a half years into the pandemic, SARS-CoV-2 is still here to stay. Whilst rapid several effective COVID-19 vaccines have been developed and are being rolled out, the critical questions remain whether vaccines provide widespread protection against infection and reinfection, and what the duration of protection is. Community wide control cannot be obtained until almost everyone is immune. Vaccine production must be ramped up to cover the world population. The price of herd immunity through natural infection is high mortality in the elderly and morbidity in other age groups including children and Long-COVID. We must expect a new wave …
Going Back To Normal, But How? Re-Opening Policies And The Standards For A New Normal, Levent Akin
Going Back To Normal, But How? Re-Opening Policies And The Standards For A New Normal, Levent Akin
Turkish Journal of Medical Sciences
Governments implemented to nonpharmacological methods and various limitation policies such as closing nonessential businesses, schools and limiting group gatherings, promoting social distancing, use of personal protective equipment, advising staying at home. These policies have caused various problems in social and economic life and gradual increase in psychosocial well-being problems. All societies yearningly are waiting for the COVID-19 pandemic to be brought under control and the measures to be lifted in order to return to their previous lives. Indicators are needed to assess the burden of disease in the country while lifting measures to control the COVID-19 pandemic. When using these …
Managing Life During The Pandemic: Communication Strategies, Mental Health, And Theultimate Toll Of The Covid-19, Mehmet Hakan Türkçapar, Yasemi̇n Kahya, Tuğba Çapar Taşkesen, Hati̇ce Işik
Managing Life During The Pandemic: Communication Strategies, Mental Health, And Theultimate Toll Of The Covid-19, Mehmet Hakan Türkçapar, Yasemi̇n Kahya, Tuğba Çapar Taşkesen, Hati̇ce Işik
Turkish Journal of Medical Sciences
Background/aim: The purpose of this review was to present the ultimate toll of the COVID-19 pandemic by focusing on the communication strategies and mental health. Materials and methods: We unsystematically reviewed the studies published between 2020 and 2021 from databases such as Google Scholar, Web of Science and ScienceDirect. Firstly, "new-normal" life challenges during the pandemic were discussed along with the public risk communication strategies. Later, mental health problems, posttraumatic growth, and protective factors were reviewed. Results: Literature highlighted that individuals mainly experience COVID-19 related fear, anxiety, stress, negative emotions and sleep problems. Furthermore, the rates of clinically significant depression, …
Epidemiology Of Covid-19: What Changed In One Year?, Cemal Bulut, Yasuyuki̇ Kato
Epidemiology Of Covid-19: What Changed In One Year?, Cemal Bulut, Yasuyuki̇ Kato
Turkish Journal of Medical Sciences
A coronavirus brought the first pandemic attack of this century as a flu virus did a hundred years ago. This greatest pandemic of the century brings us new opportunities to understand and explore the dynamics of a contagious disease. Nearly two years later, we are still collecting the evidence to understand the disease. Some basic epidemiological properties are still urgently needed. Not only the origin of the virus but also Ro value, possible transmission routes, epidemiologic curves, case fatality rates, seasonality, severity and mortality risk factor, effects on the risk groups, differences between countries and so on still require strong …
From Asymptomatic To Critical Illness - Different Clinical Manifestations Of Covid-19 Inchildren, Hasan Tezer, Meli̇s Deni̇z
From Asymptomatic To Critical Illness - Different Clinical Manifestations Of Covid-19 Inchildren, Hasan Tezer, Meli̇s Deni̇z
Turkish Journal of Medical Sciences
The global pandemic infectious disease that was named the new coronavirus disease (COVID 19), spread throughout the world, causing a major public health emergency. The causative virus of COVID-19, called SARS CoV-2, can infect all age groups. Various clinical signs and symptoms have been observed in neonates, children, and adolescents during the COVID-19 outbreak. The clinical manifestations of COVID-19 might be different due to the medical conditions and comorbid status in elderly and pediatric patients. The rise in cases among children has been reported during the COVID-19 pandemic. Although infected children generally appear to be asymptomatic or have only mild …
Multisystem Inflammatory Syndrome In Children, Selda Hançerli̇ Törün, Di̇lek Yilmaz Çi̇ftdoğan, Ateş Kara
Multisystem Inflammatory Syndrome In Children, Selda Hançerli̇ Törün, Di̇lek Yilmaz Çi̇ftdoğan, Ateş Kara
Turkish Journal of Medical Sciences
As the COVID-19 pandemic continues, children can be infected with the virus that causes COVID-19. Clinical symptoms of children with COVID from China, where the disease was first reported, generally were less severe than adults. However, at the end of April 2020 in Europe, it was observed that some children with SARS-CoV-2 infection developed fever, abdominal pain, shock, myocardial insufficiency and they needed to be taken care of in intensive care unit. This new disease has been called multisystem inflammatory syndrome in children (MIS-C). Although the pathogenesis of MIS-C is unclear, it progresses with signs of multiorgan involvement as a …
From Asymptomatic To Critical Illness: Decoding Various Clinical Stages Of Covid-19, İlhami̇ Çeli̇k, Recep Öztürk
From Asymptomatic To Critical Illness: Decoding Various Clinical Stages Of Covid-19, İlhami̇ Çeli̇k, Recep Öztürk
Turkish Journal of Medical Sciences
The clinical course of COVID-19 is variable, with clinical manifestation ranging from 81% mild course to 14% severe course along with 5% critical course in patients. The asymptomatic course is reported to potentially range between 20% and 70% (avg. 33%). A more severe course is seen in the elderly, those with various chronic diseases, and the immunosuppressed, where the case fatality rate is higher in these risk groups. The disease progresses with various symptoms, such as fever, cough, shortness of breath, malaise, myalgia, taste and smell disorders, diarrhea, sore throat, headache, and conjunctivitis. The disease begins with shortness of breath, …
Covid-19 And Sepsis, Zeli̇ha Koçak Tufan, Bi̇rcan Kayaaslan, Mervyn Mer
Covid-19 And Sepsis, Zeli̇ha Koçak Tufan, Bi̇rcan Kayaaslan, Mervyn Mer
Turkish Journal of Medical Sciences
The COVID-19 pandemic has created a major alteration in the medical literature including the sepsis discussion. From the outset of the pandemic, various reports have indicated that although there are some unique features pertinent to COVID-19, many of its acute manifestations are similar to sepsis caused by other pathogens. As a consequence, the old definitions now require consideration of this new etiologic agent, namely SARS-CoV-2. Although the pathogenesis of COVID-19 has not been fully explained, the data obtained so far in hospitalized patients has revealed that serum cytokine and chemokine levels are high in severe COVID-19 patients, similar to those …
Pregnancy And Covid-19: Prevention, Vaccination, Therapy, And Beyond, Di̇lek Şahi̇n, Atakan Tanaçan, Sophia Ne Webster, Özlem Moraloğlu Teki̇n
Pregnancy And Covid-19: Prevention, Vaccination, Therapy, And Beyond, Di̇lek Şahi̇n, Atakan Tanaçan, Sophia Ne Webster, Özlem Moraloğlu Teki̇n
Turkish Journal of Medical Sciences
: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has alarmed the world since its first emergence. As pregnancy is characterized by significant changes in cardiovascular, respiratory, endocrine, and immunological systems, there are concerns on issues like the course of disease in pregnant women, safety of medications, route of delivery and risk of obstetric complications. The aim of this review is to summarize the current literature in the management of pregnant women during the COVID-19 pandemic. Although more than 90% of pregnant women with COVID-19 recover without serious morbidity, rapid deterioration of disease and higher …
The Radiological Findings Of Covid-19, Alper Karacan, Yakup Ersel Aksoy, Mehmet Hali̇l Öztürk
The Radiological Findings Of Covid-19, Alper Karacan, Yakup Ersel Aksoy, Mehmet Hali̇l Öztürk
Turkish Journal of Medical Sciences
Background/aim: Available information on the radiological findings of the 2019 novel coronavirus disease (COVID-19) is constantly updated. Ground glass opacities (GGOs) and consolidation with bilateral and peripheral distribution have been reported as the most common CT findings, but less typical features can also be identified. According to the reported studies, SARS-CoV-2 infection is not limited to the respiratory system, and it can also affect other organs. Renal dysfunction, gastrointestinal complications, liver dysfunction, cardiac manifestations, and neurological abnormalities are among the reported extrapulmonary features. This review aims to provide updated information for radiologists and all clinicians to better understand the radiological …
Implementation Of Post-Intensive Care Outpatient Clinic (I-Point) For Critically Illcovid-19 Survivors, Burçi̇n Halaçli, Arzu Topeli̇ İski̇t
Implementation Of Post-Intensive Care Outpatient Clinic (I-Point) For Critically Illcovid-19 Survivors, Burçi̇n Halaçli, Arzu Topeli̇ İski̇t
Turkish Journal of Medical Sciences
Although we have enough and cumulative information about acute effects of COVID-19, our knowledge is extremely limited about long-term consequences of COVID-19, in terms of its impacts and burdens on patients, families, and the health system. Considering the underlying pathophysiological mechanisms affecting all of the organ systems in critically ill COVID-19 patients who are admitted to intensive care units, the development of post-intensive care syndrome is inevitable. This situation brings along the development of long-COVID. These patients should be followed regarding cognitive, physical, and psychiatric aspects and necessary specialist referrals should be carried out. In this article, we are presenting …
Immune Dysfunction In Covid-19 And Judicious Use Of Antirheumatic Drugs For Thetreatment Of Hyperinflammation, Abdurrahman Tufan, Marco Matucci-Cerinic
Immune Dysfunction In Covid-19 And Judicious Use Of Antirheumatic Drugs For Thetreatment Of Hyperinflammation, Abdurrahman Tufan, Marco Matucci-Cerinic
Turkish Journal of Medical Sciences
: In the Wuhan province of China, almost two years ago, in December 2019, the novel Coronavirus 2019 has caused a severe involvement of the lower respiratory tract leading to an acute life-threatening respiratory syndrome, coronavirus disease-19 (COVID-19). Subsequently, coronavirus 2 (SARS-CoV-2) rapidly spread to the entire world causing a pandemic and affected every single person on earth either directly or indirectly with destroying all facets of social life and economy. Since the announcement of COVID-19 as a global pandemic, we have witnessed tremendous scientific work on all aspects of COVID-19 across the globe, which has never been witnessed before. …
An Update Of Anti-Viral Treatment Of Covid-19, Serap Yavuz, Feri̇de İpek Komsuoğlu Çeli̇kyurt
An Update Of Anti-Viral Treatment Of Covid-19, Serap Yavuz, Feri̇de İpek Komsuoğlu Çeli̇kyurt
Turkish Journal of Medical Sciences
Background/aim: Currently there is not an effective antiviral treatment for COVID-19, but a large number of drugs have been evaluated since the beginning of the pandemic, and many of them have been used for the treatment of COVID-19 despite the preliminary or conflicting results of the clinical trials. We aimed to review and summarize all of the current knowledge on the antivirals for COVID-19. Results: There are 2 main drug groups for SARS-CoV-2: agents that target proteins or RNA of the virus or interfere with proteins or biological processes in the host that support the virus. The main drug groups …
Consensus Recommendations For Botulinum Toxin Injections In The Spasticitymanagement Of Children With Cerebral Palsy During Covid-19 Outbreak, Ebru Yilmaz Yalçinkaya, Nai̇me Evri̇m Karadağ Saygi, Özden Özyemi̇şci̇ Taşkiran, Nalan Çapan, Şehi̇m Kutlay, Bi̇rkan Sonel Tur, Özlem El, Ece Ünlü Akyüz, Süda Teki̇n, Demet Ofluoğlu, Murat Zi̇nnuroğlu, Pinar Akpinar, Tuğçe Özekli̇ Misirlioğlu, Berri̇n Hüner, Ahmet Hakan Nur
Consensus Recommendations For Botulinum Toxin Injections In The Spasticitymanagement Of Children With Cerebral Palsy During Covid-19 Outbreak, Ebru Yilmaz Yalçinkaya, Nai̇me Evri̇m Karadağ Saygi, Özden Özyemi̇şci̇ Taşkiran, Nalan Çapan, Şehi̇m Kutlay, Bi̇rkan Sonel Tur, Özlem El, Ece Ünlü Akyüz, Süda Teki̇n, Demet Ofluoğlu, Murat Zi̇nnuroğlu, Pinar Akpinar, Tuğçe Özekli̇ Misirlioğlu, Berri̇n Hüner, Ahmet Hakan Nur
Turkish Journal of Medical Sciences
Spasticity is the most common motor disturbance in cerebral palsy (CP). Lockdown in the COVID-19 outbreak has profoundly changed daily routines, and similarly caused the suspension of spasticity treatment plans. Besides, the delay in botulinum toxin (BoNT) injection, which is important in the management of focal spasticity, led to some problems in children. This consensus report includes BoNT injection recommendations in the management of spasticity during the COVID-19 pandemic in children with CP. In order to develop the consensus report, physical medicine and rehabilitation (PMR) specialists experienced in the field of pediatric rehabilitation and BoNT injections were invited by Pediatric …
Outcome Of Noncritical Covid-19 Patients With Early Hospitalization And Early Antiviraltreatment Outside The Icu, Nursel Çalik Başaran, Oğuz Abdullah Uyaroğlu, Gülçi̇n Telli̇ Di̇zman, Lale Özişik, Taha Koray Şahi̇n, Zahi̇t Taş, Ahmet Çağkan İnkaya, Sevi̇lay Karahan, Şehnaz Özyavuz Alp, Alpaslan Alp, Gökhan Metan, Işkin Pinar Zarakol, Gülay Sai̇n Güven, Şeri̇fe Gül Öz, Arzu Topeli̇ İski̇t
Outcome Of Noncritical Covid-19 Patients With Early Hospitalization And Early Antiviraltreatment Outside The Icu, Nursel Çalik Başaran, Oğuz Abdullah Uyaroğlu, Gülçi̇n Telli̇ Di̇zman, Lale Özişik, Taha Koray Şahi̇n, Zahi̇t Taş, Ahmet Çağkan İnkaya, Sevi̇lay Karahan, Şehnaz Özyavuz Alp, Alpaslan Alp, Gökhan Metan, Işkin Pinar Zarakol, Gülay Sai̇n Güven, Şeri̇fe Gül Öz, Arzu Topeli̇ İski̇t
Turkish Journal of Medical Sciences
Background/aim: Despite the fact that the COVID-19 pandemic has been going on for over 5 months, there is yet to be a standard management policy for all patients including those with mild-to-moderate cases. We evaluated the role of early hospitalization in combination with early antiviral therapy with COVID-19 patients in a tertiary care university hospital. Materials and methods: This was a prospective, observational, single-center study on probable/confirmed COVID-19 patients hospitalized in a tertiary care hospital on COVID-19 wards between March 20 and April 30, 2020. The demographic, laboratory, and clinical data were collected. Results: We included 174 consecutive probable/confirmed COVID-19 …
Clinical Course Of Covid-19 Disease In Immunosuppressed Renal Transplant Patients, Hamad Dhei̇r, Savaş Si̇pahi̇, Selçuk Yaylaci, Esma Seda Çeti̇n, Ahmed Bi̇lal Genç, Necatti̇n Firat, Mehmet Köroğlu, Gürkan Muratdaği, Yakup Tomak, Kezban Özmen Süner, Ömer Faruk Ateş, Oğuz Karabay
Clinical Course Of Covid-19 Disease In Immunosuppressed Renal Transplant Patients, Hamad Dhei̇r, Savaş Si̇pahi̇, Selçuk Yaylaci, Esma Seda Çeti̇n, Ahmed Bi̇lal Genç, Necatti̇n Firat, Mehmet Köroğlu, Gürkan Muratdaği, Yakup Tomak, Kezban Özmen Süner, Ömer Faruk Ateş, Oğuz Karabay
Turkish Journal of Medical Sciences
Background/aim: We aimed to identify clinical settings of renal transplant patients with COVID-19. Materials and methods: In this retrospective study, we included kidney transplant inpatients with laboratory confirmed COVID-19 who had been discharged or had died by October 1st, 2020. Characteristics of the patients, including basal and last outpatient biochemical parameters were recorded. Discontinuation or dosage reduction of immunosuppressives and other treatment information was documented. Results: Twenty patients were included in this study, of whom 18 were discharged and 2 died in hospital. The mean duration of hospitalization and follow-up were 9.7 ± 6.4 days and 4.5 ± 2.0 months, …
Pattern Of Systemic Antibiotic Use And Potential Drug Interactions: Evaluations Through Apoint Prevalence Study In Ankara University Hospitals, İrem Akdemi̇r Kalkan, Güle Çinar, Aysel Pehli̇vanli, Fati̇h Ürkmez, İzel Ezgi̇ Topaloğlu, Büşra Akyol, Arzu Beşi̇kci̇, Alpay Azap, Kemal Osman Memi̇koğlu
Pattern Of Systemic Antibiotic Use And Potential Drug Interactions: Evaluations Through Apoint Prevalence Study In Ankara University Hospitals, İrem Akdemi̇r Kalkan, Güle Çinar, Aysel Pehli̇vanli, Fati̇h Ürkmez, İzel Ezgi̇ Topaloğlu, Büşra Akyol, Arzu Beşi̇kci̇, Alpay Azap, Kemal Osman Memi̇koğlu
Turkish Journal of Medical Sciences
Background/aim: Most of the hospitalized patients are on a number of drugs for comorbidities and/or to prevent nosocomial infections. This necessitates a careful consideration of drug interactions not only to avoid possible toxicities but also to reach the highest efficiency with drug treatment. We aimed to investigate drug interactions related to systemic antibiotic use and compare three different databases to check for drug interactions while characterizing the main differences between medical and surgical departments. Materials and methods: This point prevalence study covered data on 927 orders for patients hospitalized between June 3 and 10, 2018 in Ankara University Hospitals. Systemic …
Retrospective Evaluation Of 377 Patients With Penetrating Foreign Body Injuries: Auniversity Hospital Experience (A Present Case Of Missed Sponge Foreign Body Injury), Anil Murat Öztürk, Omar Aljasim, Gamze Şanlidağ, Meltem Taşbakan
Retrospective Evaluation Of 377 Patients With Penetrating Foreign Body Injuries: Auniversity Hospital Experience (A Present Case Of Missed Sponge Foreign Body Injury), Anil Murat Öztürk, Omar Aljasim, Gamze Şanlidağ, Meltem Taşbakan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to retrospectively analyse patients with foreign body (FB) injuries in our hospital and to present a patient with missed penetrating sponge FB injury. Materials and methods: This study lasted 12 years (2008-2020) and reviewed all patients with FB injuries who were admitted to the emergency department (ED) of our hospital. Along with our overall results, we present a case with missed penetrating sponge FB injury in detail. Results: Approximately 377 patients were included in the study (age: 28.3 ± 18.3 years, m/f: 229/148). The foot (n = 148, 39.3%) and the hand (n = 143, 37.9%) …
Characteristics And Mortality Determinants Of Covid-19 Patients Undergoinghemodialysis, Savaş Si̇pahi̇, Hamad Dhei̇r, Aysel Toçoğlu, Meli̇ke Bektaş, Seyyi̇d Bi̇lal Açikgöz, Ahmed Ci̇had Genç, Fuldem Mutlu, Mehmet Köroğlu, Ali̇ Fuat Erdem, Oğuz Karabay
Characteristics And Mortality Determinants Of Covid-19 Patients Undergoinghemodialysis, Savaş Si̇pahi̇, Hamad Dhei̇r, Aysel Toçoğlu, Meli̇ke Bektaş, Seyyi̇d Bi̇lal Açikgöz, Ahmed Ci̇had Genç, Fuldem Mutlu, Mehmet Köroğlu, Ali̇ Fuat Erdem, Oğuz Karabay
Turkish Journal of Medical Sciences
Background/aim: The COVID-19 infection, which started in Wuhan City, China, in December 2019, turned into a pandemic in a very short time, affecting mainly the elderly and those with serious chronic illnesses. COVID-19 infections have been observed to have a high mortality rate, especially in patients undergoing maintenance hemodialysis. Materials and methods: Forty-two patients over 18 years of age who underwent a maintenance hemodialysis program at our unit, who tested positive for COVID-19 by PCR from nasopharyngeal swabs, and/or who were observed to have disease-related signs in their CTs were included in the study. Results: In this study, 23 of …
Nonsteroidal Antiinflammatory Drugs Alter Antibiotic Susceptibility And Expression Ofvirulence-Related Genes And Protein A Of Staphylococcus Aureus, İsmai̇l Öztürk, Yasemi̇n Eraç, Petek Ballar Kirmizibayrak, Şafak Ermertcan
Nonsteroidal Antiinflammatory Drugs Alter Antibiotic Susceptibility And Expression Ofvirulence-Related Genes And Protein A Of Staphylococcus Aureus, İsmai̇l Öztürk, Yasemi̇n Eraç, Petek Ballar Kirmizibayrak, Şafak Ermertcan
Turkish Journal of Medical Sciences
Background/aim: Nonsteroidal antiinflammatory drugs (NSAIDs) including diclofenac, naproxen, ibuprofen, acetylsalicylic acid, and acetaminophen have been shown to have antimicrobial effects on various microorganisms. The aim of this study was to investigate the antibacterial effects of NSAIDs on Staphylococcus aureus. Materials and methods: Susceptibilities of S. aureus strains to NSAIDs with or without antimicrobials (moxifloxacin, vancomycin, ciprofloxacin, clindamycin, and gentamicin) were determined using the microdilution method and disk diffusion test. Expression levels of genes in the presence of drugs were investigated by real-time quantitative RT-PCR (qRT-PCR), and immunoblotting analysis was performed for staphylococcal protein A (SpA). Results: Our results showed that …
First Report On Mild Insecticide Resistance In Newly Established Aegean Aedes Albopictus Populations Of Turkey, Sare İlknur Yavaşoğlu
First Report On Mild Insecticide Resistance In Newly Established Aegean Aedes Albopictus Populations Of Turkey, Sare İlknur Yavaşoğlu
Turkish Journal of Zoology
The invasive nature of Aedes albopictus, a competent vector of dengue, zika, yellow fever, and chikungunya viruses, has spread to many parts of the world. To date, there have been no report regarding the insecticide resistance status of Aedes albopictus populations along the Aegean coasts of Turkey. This study aims to confirm the occurrence of Aedes albopictus populations in the Aegean region of Turkey and test their susceptibility against different insecticide classes. Bioassay for susceptibility to Dikloro difenil trikloroetan (DDT) (4%), propoxur (0.1%), fenitrothion (1%), bendiocarb (0.1%), permethrin (0.75%), and deltamethrin (0.05%) of each population was assessed through the World …
Towards An Ontology-Based Approach To The "New Normality" After Covid-19:The Spanish Case During Pandemic First Wave, Evelio Gonzalez
Towards An Ontology-Based Approach To The "New Normality" After Covid-19:The Spanish Case During Pandemic First Wave, Evelio Gonzalez
Turkish Journal of Electrical Engineering and Computer Sciences
The impact of the pandemic caused by COVID-19 has been immense in all fields of human activity. In most of the affected countries, the authorities have decreed a series of legal measures to try to stop the growth of the disease and the number of people affected by it. These legal measures involved, in most cases, restrictions on the free movement of people and on work and trade activities, new hygiene procedures, and social distancing. In the particular case of Spain, the rapid evolution of the pandemic led to the declaration of a so-called state of alarm and a period …
Do Initial Hematologic Indices Predict The Severity Of Covid-19 Patients?, Ali̇ Asan, Yasemi̇n Üstündağ, Ni̇zameddi̇n Koca, Abdullah Şi̇mşek, Hali̇l Erkan Sayan, Hülya Parildar, Burcu Dalyan Ci̇lo, Kağan Huysal
Do Initial Hematologic Indices Predict The Severity Of Covid-19 Patients?, Ali̇ Asan, Yasemi̇n Üstündağ, Ni̇zameddi̇n Koca, Abdullah Şi̇mşek, Hali̇l Erkan Sayan, Hülya Parildar, Burcu Dalyan Ci̇lo, Kağan Huysal
Turkish Journal of Medical Sciences
Background/aim: In this study, we aimed to evaluate the initial hematological findings analyzed on admission in confirmed COVID-19 patients who were transferred to the intensive care unit (ICU), to predict possible hematological indices. Materials and methods: Initial neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), red cell distribution width to platelet ratio (RPR), mean platelet volume to platelet ratio, and lymphocyte multiplied by platelet count (LYM × PLT), of 695 patients with laboratory-confirmed COVID-19 were investigated and comparisons were made between the mild/moderate and severe groups. Results: The proportion of COVID-19 cases admitted …