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The Effect Of Artificial Insemination Timing On The Sex Ratio Of Offspring And Fertility In Dairy Cows, Orkun Demi̇ral, Mustafa Ün, Murat Abay, Tayfur Bekyürek Jan 2007

The Effect Of Artificial Insemination Timing On The Sex Ratio Of Offspring And Fertility In Dairy Cows, Orkun Demi̇ral, Mustafa Ün, Murat Abay, Tayfur Bekyürek

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to investigate the effect of the interval between artificial insemination and the onset of estrus on the sex ratio of offspring and fertility in Holstein cows. Standing to be mounted behavior was considered the beginning of estrus, and artificial inseminations were performed 6 h (Group 1), 9 h (Group 2), 12 h (Group 3), and 15 h (Group 4) after the onset of estrus in cows. Overall 119 (n: 85), 107 (n: 72), 120 (n: 80) and 119 (n: 83) artificial inseminations were performed in Groups 1, 2, 3 and 4, respectively. Pregnancy rates …


Acid Adaptation Effect On Survival Of Escherichia Coli O157:H7 In Fermented Milk Products, Hali̇l Tosun, A. Kemal Seçki̇n, Şahi̇ka Aktuğ Gönül Jan 2007

Acid Adaptation Effect On Survival Of Escherichia Coli O157:H7 In Fermented Milk Products, Hali̇l Tosun, A. Kemal Seçki̇n, Şahi̇ka Aktuğ Gönül

Turkish Journal of Veterinary & Animal Sciences

The growth and survival of acid-adapted and nonadapted Escherichia coli O157:H7 were determined in strained, set-type, and synbiotic yoghurt and kefir. Acid-adapted or nonadapted E. coli O157:H7 were inoculated into the synbiotic and set-type yoghurt before and after the fermentation process. Survival of the inoculated E. coli O157:H7 in these products was examined during storage at 4 °C. Acid adaptation enhanced the survival of E. coli O157:H7 in kefir and strained yoghurt. Acid adaptation also enhanced the survival of E. coli O157:H7 in set-type yoghurt, which was inoculated after the fermentation process; however, acid-adapted cell inoculation before fermentation did not …


Chondroma In A Dog, Rifki Haziroğlu, Hasan Bi̇lgi̇li̇, Kübra A. Teri̇m Kapakin Jan 2007

Chondroma In A Dog, Rifki Haziroğlu, Hasan Bi̇lgi̇li̇, Kübra A. Teri̇m Kapakin

Turkish Journal of Veterinary & Animal Sciences

An 11-year-old female terrier brought to our clinic was diagnosed with chondroma located on the caudolateral side of the right distal humerus. During the clinical examination of the dog, swelling and lameness were observed on right forelimb. Following the operation, the subject had no lameness after removing the mass. Postoperative follow-up was done by phone with the owner of the patient in 6th and 12th months, and no lameness and swelling in the region was reported. The tumoral mass was removed easily from underlying tissue without any attachment during the operation. The tissue sample from the specimen was routinely processed …


Enterotoxemia In A Cow Due To Clostridium Perfringens Type A, Hakan Kalender, Ayşe Kiliç, Eray Atil Jan 2007

Enterotoxemia In A Cow Due To Clostridium Perfringens Type A, Hakan Kalender, Ayşe Kiliç, Eray Atil

Turkish Journal of Veterinary & Animal Sciences

Enterotoxemia was diagnosed in a 3-year-old cow that died suddenly. Lesions of hemorrhagic enteritis were seen in the small intestine during necropsy. Lethal alpha toxin of Clostridium perfringens was detected in the intestinal contents by toxin neutralization test. C. perfringens type A was isolated from the intestinal contents and typed by multiplex PCR. Enterotoxemia should be considered as a cause of sudden death in cattle in Turkey.


Acute Toxicity Of Carbaryl, Methiocarb, And Carbosulfan To The Rainbow Trout (Oncorhynchus Mykiss) And Guppy (Poecilia Reticulata), Muhammet Boran, İlhan Altinok, Erol Çapkin, Hi̇kmet Karaçam, Veysel Bi̇çer Jan 2007

Acute Toxicity Of Carbaryl, Methiocarb, And Carbosulfan To The Rainbow Trout (Oncorhynchus Mykiss) And Guppy (Poecilia Reticulata), Muhammet Boran, İlhan Altinok, Erol Çapkin, Hi̇kmet Karaçam, Veysel Bi̇çer

Turkish Journal of Veterinary & Animal Sciences

The acute toxicity of carbaryl, methiocarb and carbosulfan to juvenile rainbow trout (Oncorhynchus mykiss; 1.92 ± 0.5 g) and guppies (Poecilia reticulata; 0.45 ± 0.04 g) was evaluated in 96-h toxicity tests under static conditions. Concentrations in the toxicity test ranged from 0.85 to 8.5 mg/l for carbaryl, from 0.7 to 28.0 mg/l for methiocarb, and from 0.031 to 12.5 mg/l for carbosulfan. Carbaryl and methiocarb were more toxic to rainbow trout than to guppies. However, compared with rainbow trout, guppies were more sensitive to carbosulfan. The incidence of mortality in fish increased significantly (P < 0.05) with increasing pesticide concentrations. The time required to kill 50% (LT_{50}) of the rainbow trout at the lowest concentrations of carbaryl, methiocarb, and carbosulfan was 51 h 12 min, 74 h 35 min, and 107 h 57 min, respectively. As insecticide concentrations were increased, LT_{50} values decreased (P < 0.05).


Isolation Of Salmonella Spp. In Camel Sausages From Retail Markets In Aydın, Turkey, And Polymerase Chain Reaction (Pcr) Confirmation, Gökben Özbey, Fi̇li̇z Kök, Adi̇le Muz Jan 2007

Isolation Of Salmonella Spp. In Camel Sausages From Retail Markets In Aydın, Turkey, And Polymerase Chain Reaction (Pcr) Confirmation, Gökben Özbey, Fi̇li̇z Kök, Adi̇le Muz

Turkish Journal of Veterinary & Animal Sciences

A total of 100 camel sausage samples from different retail markets in Aydın, located in southwest Turkey, were examined for the presence of Salmonella spp. by culture method. After sausage samples was preenriched in buffered peptone water and incubated 18-20 h at 37 °C. were transferred to Rappaport-Vassiliadis broth and Selenite broth, respectively, and incubated at 42 and 37 °C, respectively. After 24 and 48 h of incubation, one loopful from each of the enriched broths was streaked onto plates of Salmonella-Shigella agar and xylose lysine deoxycholate agar and incubated at 37 °C for 24 h. A 572-bp fragment of …


Cover And Contents Jan 2007

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.


The Use Of Hazelnut Meal As A Substitute For Soybean Meal In The Diets Of Rainbow Trout (Oncorhynchus Mykiss), Özlem Bi̇lgi̇n, Ali̇ Türker, Ahmet Adem Teki̇nay Jan 2007

The Use Of Hazelnut Meal As A Substitute For Soybean Meal In The Diets Of Rainbow Trout (Oncorhynchus Mykiss), Özlem Bi̇lgi̇n, Ali̇ Türker, Ahmet Adem Teki̇nay

Turkish Journal of Veterinary & Animal Sciences

Hazelnut meal as a substitute for soybean meal in extruded feeds of rainbow trout was investigated. The performance of extruded feeds containing hazelnut meal as a substitute for 20% of soybean meal (Diet 2) and 30% of soybean meal (Diet 3) was compared to a nutritionally balanced control (Diet 1) (a commercial trout feed formulation). Each diet was fed to 3 replicate groups (initial BW: 36 ± 1.37 g; mean ± SD); the fish were fed the equivalent of 2% of their body weight, 2 times daily (0800 and 1600) for 64 days at 15 ± 0.11 °C under a …


Changes In Some Blood Biochemical And Haematological Parameters In Goats After Aminoglycoside And Aminocyclitol Treatment At Therapeutic Doses, Toncho Dinev, Dimitrinka Zapryanova, Lubomir Lashev Jan 2007

Changes In Some Blood Biochemical And Haematological Parameters In Goats After Aminoglycoside And Aminocyclitol Treatment At Therapeutic Doses, Toncho Dinev, Dimitrinka Zapryanova, Lubomir Lashev

Turkish Journal of Veterinary & Animal Sciences

The aim of the present study was to determine the changes in some blood biochemical and haematological parameters in healthy female goats after a 5-day parenteral treatment with gentamicin (4 mg/kg), tobramycin (5 mg/kg), amikacin (10 mg/kg), kanamycin (10 mg/kg), apramycin (20 mg/kg), and spectinomycin (20 mg/kg). The results indicated that aminoglycosides caused more severe alterations than aminocyclitols, especially on those parameters related to renal function. There was a tendency toward a rise in plasma creatinine and urea levels after aminoglycoside treatment, as well as a rise in urea levels after aminocyclitol administration. These antibiotics caused decreases in plasma or …


Histopathological Changes After Transplantation Of Stored Osteochondral Allografts Into Articular Cartilage Lesions In Dogs, Zbigniew Adamiak, Wojciech Brzeski Jan 2007

Histopathological Changes After Transplantation Of Stored Osteochondral Allografts Into Articular Cartilage Lesions In Dogs, Zbigniew Adamiak, Wojciech Brzeski

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to evaluate histopathological changes in the recipient site after transplantation of stored osteochondral allografts into articular cartilage defects in 8 dogs. In all dogs a single osteochondral allograft was transplanted into articular cartilage lesions. The results of the completed surgeries include a 12-month follow-up study. It was found that the stored osteochondral allografts were very firmly connected to the recipient tissue and no arthritis changes were noted.


Seroepidemiology Of Equine Influenza Virus Infection In Turkey, Veysel Soydal Ataseven, Janet Mary Daly Jan 2007

Seroepidemiology Of Equine Influenza Virus Infection In Turkey, Veysel Soydal Ataseven, Janet Mary Daly

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to investigate the seroepidemiology of equine influenza infection in Turkey, measured using the haemagglutination inhibition (HI) assay. Serum samples were obtained from 623 equids aged older than 4 years from 5 different geographical regions in Turkey during the years 2003-2005. Antibodies against equine influenza virus (EIV) were found in 194 (31.1%) of the 623 sera. Seropositivity rates were detected as 41.8% (171/409), 12.8% (11/86), and 9.4% (12/128) in horses, mules, and donkeys, respectively. The data revealed that EIV circulates in Turkey at a relatively high rate. Differences in seropositivity rates in Equidae from different …


Accidental Poisoning From Lantana Camara (Cherry Pie) Hay Fed To Ostriches (Struthio Camelus), Ross G. Cooper Jan 2007

Accidental Poisoning From Lantana Camara (Cherry Pie) Hay Fed To Ostriches (Struthio Camelus), Ross G. Cooper

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.


Serum Biochemical Changes In Experimental Gambian Trypanosomosis. Ii. Assessing Hepatic And Renal Dysfunction, J. N. Abenga, V. O. Anosa Jan 2007

Serum Biochemical Changes In Experimental Gambian Trypanosomosis. Ii. Assessing Hepatic And Renal Dysfunction, J. N. Abenga, V. O. Anosa

Turkish Journal of Veterinary & Animal Sciences

Serum biochemical changes were assessed to determine hepatic and renal function in 4 vervet monkeys experimentally infected with Trypanosoma brucei gambiense, the causative agent of sleeping sickness in West and Central Africa. Parameters examined included serum bilirubin, blood urea nitrogen (BUN), and cholesterol levels. Significant increases in the total bilirubin and BUN levels occurred from the second week post-infection (PI) (P Keywords: Serum biochemistry, trypanosomosis, human, monkeys


The Effects Of Planting Time And Combination On The Nutrient Composition And Digestible Dry Matter Yield Of Four Mixtures Of Vetch Varieties Intercropped With Barley, N. Tuğba Bi̇ngöl, M. Aki̇f Karsli, İ. Hakki Yilmaz, Duran Bolat Jan 2007

The Effects Of Planting Time And Combination On The Nutrient Composition And Digestible Dry Matter Yield Of Four Mixtures Of Vetch Varieties Intercropped With Barley, N. Tuğba Bi̇ngöl, M. Aki̇f Karsli, İ. Hakki Yilmaz, Duran Bolat

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to determine the chemical composition, digestibility, energy content, and digestible dry matter yield of 4 mixtures of different vetch varieties intercropped with the same barley at 3 different planting times under Eastern Anatolian conditions. Four different vetch species, i.e. common (Farukbey-2001), Hungarian (Tarım Beyazı-98), hairy (Selçuklu-2002), and wooly pod (Segmen-2002), intercropped with barley (Tokak-157) were utilized. The mixtures of vetches intercropped with barley were planted on 7 October 2003 (I), 7 November 2003 (II), and 10 April 2004 (III), and each variety/planting time was randomly assigned to 3 replications. The mixtures of vetches intercropped …


The Prevalence Of Borrelia Burgdorferi Sensu Lato In Ixodes Ricinus Ticks In The Sinop Region Of Turkey, Turabi̇ Güneş, Serpi̇l Kaya, Ömer Poyraz, Aynur Engi̇n Jan 2007

The Prevalence Of Borrelia Burgdorferi Sensu Lato In Ixodes Ricinus Ticks In The Sinop Region Of Turkey, Turabi̇ Güneş, Serpi̇l Kaya, Ömer Poyraz, Aynur Engi̇n

Turkish Journal of Veterinary & Animal Sciences

This study was conducted in order to determine the prevalence of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks, which are the primary vectors of this spirochete, as well as to investigate the effect of I. ricinus population density on the prevalence of B. burgdorferi s.l. Ticks were collected by blanket dragging in 13 different forest regions of Sinop, Turkey, and its vicinity. Ticks were identified under a stereomicroscope. I. ricinus (n = 334), I. hexagonus (n = 5), Rhipicephalus spp. (n = 10), Dermacentor spp. (n = 7), and Hyalomma spp. (n = 5) were collected. Direct immunofluorescence was …


Effect Of Sodium Lactate On The Microbiological Quality And Shelf Life Of Sausages, Enver Bariş Bi̇ngöl, Kami̇l Bostan Jan 2007

Effect Of Sodium Lactate On The Microbiological Quality And Shelf Life Of Sausages, Enver Bariş Bi̇ngöl, Kami̇l Bostan

Turkish Journal of Veterinary & Animal Sciences

This study was performed to investigate the effects of various levels of sodium lactate on the microbiological quality and shelf life of sausages, and determine whether it can be used as a nitrite alternative. For this purpose, 0%, 0.6%, 1.2%, and 1.8% NaL and 0.125% NaNO_2 were added to sausage samples. Samples were vacuum-packaged and stored at 4 °C for 60 days and periodically analyzed for their sensorial properties, microbial counts (aerobic plate count, lactic acid bacteria, yeast-mould, and sulphite reducing anaerobic bacteria), and pH values. Sensorial characteristics were not altered with NaL addition; the flavor of the samples was …


The Effects Of Fermented Soybean Meal On Growth Performance And Immune Characteristics In Weaned Piglets, Xin Liu, Jianlei Feng, Zirong Xu, Yaping Lu, Yuanyuan Liu Jan 2007

The Effects Of Fermented Soybean Meal On Growth Performance And Immune Characteristics In Weaned Piglets, Xin Liu, Jianlei Feng, Zirong Xu, Yaping Lu, Yuanyuan Liu

Turkish Journal of Veterinary & Animal Sciences

This experiment was conducted to determine the effects of fermented soybean meal (FSBM) on growth performance and immune characteristics of piglets. In all, 60 crossbred piglets (Duroc x Landrace x Yorkshire) were allocated to 2 dietary treatments; 3 replications of 10 pigs were used for each treatment, and all piglets were weaned at 35 days and fed for 23 days. The results showed that average daily gain (ADG) improved (1.44% vs. 1.36%) in piglets fed the FSBM diet and feed gain ratio (FGR) decreased by 5.56% (P < 0.05) compared to the controls (soybean meal treatment). The level of serum IgG decreased 27.2% (P < 0.01) in piglets fed FSBM. Lymphocytes from whole blood had a lower proliferative response to concanavalin A (ConA) (P < 0.01) and lipopolysaccharide (LPS) (P < 0.05). Meanwhile, the splenocytes of piglets fed FSBM also showed lower proliferative response to ConA (P < 0.05) and LPS (P < 0.01). The results indicated that FSBM was beneficial to growth performance and decreased the immune response to soybean protein in piglets.


Determination Of Clostridium Perfringens Toxin-Types In Sheep With Suspected Enterotoxemia In Kars Province, Turkey, Hali̇l İbrahi̇m Gökce, Oktay Genç, Mahmut Sözmen, Gürbüz Gökçe Jan 2007

Determination Of Clostridium Perfringens Toxin-Types In Sheep With Suspected Enterotoxemia In Kars Province, Turkey, Hali̇l İbrahi̇m Gökce, Oktay Genç, Mahmut Sözmen, Gürbüz Gökçe

Turkish Journal of Veterinary & Animal Sciences

The study was designed to determine the types of Clostridium perfringens and their toxins in sheep with suspected enterotoxemia in Kars province. For this purpose, 260 dead sheep with suspected enterotoxemia and 35 clinically healthy sheep (controls) of different ages and breeds were used. Intestinal contents of each sheep were collected and used to determine alpha, beta, and epsilon toxins of C. perfringens using enzyme-linked immunosorbent assay (ELISA) and the latex agglutination test (LAT). Based on ELISA and LAT, 220 (84.61%) and 152 (58.46%) sheep, respectively, were positive for C. perfringens toxins. In contrast, 40 (15.38%) sheep were toxin-negative based …


Immunohistochemical Expression Of Estrogen And Progesterone Receptors In Oviduct Adenocarcinomas In Laying Hens, M. Özgür Özyi̇ği̇t, Gürsel Sönmez Jan 2007

Immunohistochemical Expression Of Estrogen And Progesterone Receptors In Oviduct Adenocarcinomas In Laying Hens, M. Özgür Özyi̇ği̇t, Gürsel Sönmez

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to demonstrate the presence of estrogen and progesterone receptors (ERs and PRs, respectively) in oviduct adenocarcinomas in laying hens. In all, 32 oviduct adenocarcinomas (18 primary tumors and 14 intestinal metastases) from Babcock B-380 laying hens 16-18 months old were stained with commercially available monoclonal antibodies against mouse-anti-human ERs and mouse-anti-human PRs. In the microscopic examination, 13 tumors (7 oviduct adenocarcinomas and 6 intestinal metastases) stained positively for ERs and 12 tumors (4 oviduct adenocarcinomas and 8 intestinal metastases) gave a positive reaction to PR antibody. The staining pattern of the tumor cells with …


Effects Of Breed And Lactation Period On Some Characteristics And Free Fatty Acid Composition Of Raw Milk From Damascus Goats And German Fawn X Hair Goat B_1 Crossbreds, Zehra Güler, Mahmut Keski̇n, Tuğrul Masatçioğlu, Sabri̇ Gül, Osman Bi̇çer Jan 2007

Effects Of Breed And Lactation Period On Some Characteristics And Free Fatty Acid Composition Of Raw Milk From Damascus Goats And German Fawn X Hair Goat B_1 Crossbreds, Zehra Güler, Mahmut Keski̇n, Tuğrul Masatçioğlu, Sabri̇ Gül, Osman Bi̇çer

Turkish Journal of Veterinary & Animal Sciences

The effects of breed and period of lactation on milk composition were investigated. For this purpose, 8 crossbred (3/4 German fawn 1/4 Hair goat) and 10 Damascus goats were kept under identical management conditions. Lactation period affected milk yield and milk composition in both goat breeds. Milk yield, lactation duration, and mean solid and fat values showed differences between the breeds. The mean values of total solid and fat of milk during lactation were 13.82 ± 0.294% and 4.55 ± 0.223% for the crossbreds, and 12.90 ± 0.179% and 4.02 ± 0.142% for Damascus goats, respectively. Although the percentages of …


Selenium And Trace Element Distribution In Astragalus Plants: Developing A Differential Pulse Polarographic Method For Their Determination, Güler Somer, A. Cengi̇z Çalişkan Jan 2007

Selenium And Trace Element Distribution In Astragalus Plants: Developing A Differential Pulse Polarographic Method For Their Determination, Güler Somer, A. Cengi̇z Çalişkan

Turkish Journal of Chemistry

Astragalus plants have a wide range of applications in pharmaceuticals (gum tragacanth), as thickening agents in foods, and may have applications in controlling cancer cells. They are used as feed for animals and they are indicator plants for selenium. Because of their use in health-related areas it is very important to determine their selenium and trace element content with high accuracy. A new differential pulse polarographic method was established for trace element determination (10 elements) and their distribution in these plants. The Astragalus plants investigated in this work are Astragalus microcephalus and Astragalus lusitanicus, which grow almost everywhere. Their roots, …


Cover And Contents Jan 2007

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.


Investigation Of Some 1,3-Diols For The Requirements Of Solvent Extraction Of Boron: 2,2,6-Trimethyl-1,3 Heptanediol As A Potential Boron Extractant, Bi̇lsen Tural, Servet Tural, Hali̇l Hoşgören Jan 2007

Investigation Of Some 1,3-Diols For The Requirements Of Solvent Extraction Of Boron: 2,2,6-Trimethyl-1,3 Heptanediol As A Potential Boron Extractant, Bi̇lsen Tural, Servet Tural, Hali̇l Hoşgören

Turkish Journal of Chemistry

Eighteen 1,3-diols were synthesized and their structure and distribution ratio for the solvent extraction of boron were studied. Diols with a high distribution ratio (D_{B(OH)_3 > 10) were investigated for the requirements of solvent extraction of boron. Their extraction capacity, and solubility in aqueous phase and in organic diluents were investigated by comparison to 2-ethyl-1,3-hexanediol (EHD), which is widely used as a boron extractant. Among a series of 1,3 diols, 1-benzyl-2,2-dimethyl-1,3-propanediol (4a) and 2,2,6-trimethyl-1,3-heptanediol (3a) were found to have very low solubility in the aqueous phase compared to the others. IPD (3a) was found to have a high solubility in aliphatic …


Cover And Contents Jan 2007

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.


Cover And Contents Jan 2007

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.


Cover And Contents Jan 2007

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.


Synthesis Of Some New 1-Acylthiosemicarbazides And 1,2,4-Triazol-5-Thiones, And Their Analgesic And Anti-Inflammatory Activities, Yasemi̇n Dündar, Bi̇lge Çakir, Esra Küpeli̇, M. Fethi̇ Şahi̇n, Ni̇ngur Noyanalpan Jan 2007

Synthesis Of Some New 1-Acylthiosemicarbazides And 1,2,4-Triazol-5-Thiones, And Their Analgesic And Anti-Inflammatory Activities, Yasemi̇n Dündar, Bi̇lge Çakir, Esra Küpeli̇, M. Fethi̇ Şahi̇n, Ni̇ngur Noyanalpan

Turkish Journal of Chemistry

We synthesized new 1-[3-(2-oxobenzothiazolin-3-yl)propanoyl]-4- substituted-thiosemicarbazides and their corresponding cyclized 3-[2-(2-oxobenzothiazoline-3-yl)ethyl]-4-substituted-1,2,4-triazol-5-thione ana-logs in which position 4 of the triazole ring was substituted by cyclohexyl, methyl, allyl, phenyl, p-methylphenyl, p-methoxyphenyl, p-chlorophenyl, p-nitrophenyl, benzyl, and phenylethyl to screen their analgesic and anti-inflammatory activities as well as gastric ulceration potential in test animals. None of the compounds, except 5a, 5e, and 5h, caused gastric lesions or bleeding. Compound 5g was found to have higher analgesic and anti-inflammatory activity among the synthesized compounds.


Cover And Contents Jan 2007

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.


Cover And Contents Jan 2007

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.


Synthesis Of The Amide Derivatives Of 3-[1-(3-Pyridazinyl)-5-Phenyl-1h-Pyrazole-3-Yl]Propanoic Acids As Potential Analgesic Compounds, Erden Banoğlu, Murat Şüküroğlu, Burcu Çalişkan Ergün, Sultan Nacak Baytaş, Eda Aypar, Mustafa Ark Jan 2007

Synthesis Of The Amide Derivatives Of 3-[1-(3-Pyridazinyl)-5-Phenyl-1h-Pyrazole-3-Yl]Propanoic Acids As Potential Analgesic Compounds, Erden Banoğlu, Murat Şüküroğlu, Burcu Çalişkan Ergün, Sultan Nacak Baytaş, Eda Aypar, Mustafa Ark

Turkish Journal of Chemistry

A series of structurally diverse amide derivatives of 3-[1-(3-pyridazinyl)-5-phenyl-1H-pyrazole-3-yl]propanoic acids were prepared and tested for their in vivo analgesic activity using an acetic acid induced writhing test. All the test compounds displayed approximately equipotent analgesic activity to aspirin. The results showed that the analgesic activity of 5a, 5f, 5n, and 5o is significantly higher than that of 5d.