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Using Plant Extracts To Reduce Asexual Reproduction Of Apple Scab (Venturia Inaequalis), János Bálint, Szilveszter Nagy, Rezso Thiesz, Imre-István Nyárádi, Adalbert Balog
Using Plant Extracts To Reduce Asexual Reproduction Of Apple Scab (Venturia Inaequalis), János Bálint, Szilveszter Nagy, Rezso Thiesz, Imre-István Nyárádi, Adalbert Balog
Turkish Journal of Agriculture and Forestry
The aim our research was to develop effective methods for organic apple farming, based on the use of plant extracts to control the asexual reproduction of Venturia inaequalis. Plant extracts of artemisinin, chelidonine, thymol, and populin tested in vitro under laboratory conditions significantly slowed down the germination of V. inaequalis conidia. During a 2-year study under field conditions, the effect of 1% populin, an extract from black poplar buds, on apple scab was tested in parallel with synthetic fungicides and a no-pesticide regime on Golden Delicious and Jonathan apples. Populin significantly reduced the number of scabbed leaves and fruits on …
Aging And Cancer: Molecular Facts And Awareness For Turkey, Gülgün Gündüz, Kayahan Fişkin
Aging And Cancer: Molecular Facts And Awareness For Turkey, Gülgün Gündüz, Kayahan Fişkin
Turkish Journal of Biology
Two important subjects concerning extension of the human life-span are biological aging processes and their relationship to diseases, and especially to the formation of cancer. It is clear that an aging population poses some challenges for developing countries. We set out to show the demographic structure of Turkey and to discuss the feasibility of decreasing the prevalence of cancer. We overviewed the literature on the relationship between biological aging and cancer formation, the environmental causes of cancer, and age-related characteristics of cancer in the elderly. In addition, some statistical data on the changing demography of Turkey were reviewed. It is …
Autophagy And Cancer, Hacer Ezgi̇ Karakaş, Devri̇m Gözüaçik
Autophagy And Cancer, Hacer Ezgi̇ Karakaş, Devri̇m Gözüaçik
Turkish Journal of Biology
Autophagy is an evolutionary conserved intracellular degradation and stress response mechanism that is mainly responsible for the breakdown and recycling of cytoplasmic materials, including long-lived proteins, protein aggregates, and damaged organelles. In this way, autophagy provides the cell with building blocks and allows the maintenance of homeostasis under stress conditions such as growth factor deficiency, nutrient deprivation, hypoxia, and toxins. Consequently, abnormalities of autophagy contribute to a number of pathologies ranging from neurodegenerative diseases to cancer. Autophagy was reported to have a dual role in cancer. Depending on cancer stage, autophagy seems to act as tumor suppressor or as a …
Invadopodia: Proteolytic Feet Of Cancer Cells, Gi̇zem Bati, Devri̇m Pesen Okvur
Invadopodia: Proteolytic Feet Of Cancer Cells, Gi̇zem Bati, Devri̇m Pesen Okvur
Turkish Journal of Biology
The leading cause of death in cancer patients is metastasis. Invasion is an integral part of metastasis and is carried out by proteolytic structures called invadopodia at the cellular level. In this introductory review, we start by evaluating the definition of invadopodia. While presenting the upstream signaling events involved, we integrate current models on invadopodia. In addition, we discuss the significance of invadopodia in 2D and 3D and in vivo. We finally point out technical challenges and conclude with open questions in the field.
It Takes 2 Antioxidants To Tango: The Interaction Between Manganese Superoxide Dismutase And Glutathione Peroxidase-1, Dede N. Ekoue, Alan M. Diamond
It Takes 2 Antioxidants To Tango: The Interaction Between Manganese Superoxide Dismutase And Glutathione Peroxidase-1, Dede N. Ekoue, Alan M. Diamond
Turkish Journal of Biology
Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism. Accumulation of ROS without an effective antioxidant response can lead to oxidative stress, resulting in macromolecular damage that is implicated in the etiology of various diseases including cancer. ROS detoxification is regulated by various antioxidant proteins, specifically manganese superoxide dismutase (MnSOD), which catalyzes the conversion of superoxide into H_{2}O_{2}, and the subsequent conversion of H_{2}O_{2} into water is catalyzed by glutathione peroxidase 1 (GPx-1). In vitro and in vivo evidence supports a conflicting role of MnSOD in tumor biology and indicates that an interaction between MnSOD and GPx-1 can modulate …
Assessment Of Density-Dependent Feeding Damage By The Cotton Dusky Bug, Oxycarenus Laetus Kirby (Hemiptera: Lygaeidae), In Cotton, Muhammad Ahsan Khan, Muhammad Dildar Gogi, Muhammad Hamid Bashir, Mubasher Hussain, Zain-Ul Abdin, Muhammad Aamir Rashid
Assessment Of Density-Dependent Feeding Damage By The Cotton Dusky Bug, Oxycarenus Laetus Kirby (Hemiptera: Lygaeidae), In Cotton, Muhammad Ahsan Khan, Muhammad Dildar Gogi, Muhammad Hamid Bashir, Mubasher Hussain, Zain-Ul Abdin, Muhammad Aamir Rashid
Turkish Journal of Agriculture and Forestry
The dusky cotton bug, Oxycarenus laetus Kirby (Hemiptera: Lygaeidae), is a serious threat to cotton due to early cultivation of Bt cotton. These studies were carried out under laboratory and field conditions to estimate the feeding damage caused by O. laetus to seed weight, seed germination, and lint quality of cotton cultivar Bt-121 at 6 bug densities (0, 5, 10, 15, 20, and 25 adult pairs). The results revealed that seed germination and seed weight decreased, whereas percent reduction in seed germination and seed weight over control increased with increasing bug density. Bug density in the range of 5-25 pairs …
Antioxidant And Radical Scavenging Activities In Fruits Of 6 Sea Buckthorn (Hippophae Rhamnoides L.) Cultivars, Otakar Rop, Sezai̇ Erci̇şli̇, Jiri Mlcek, Tunde Jurikova, Ignac Hoza
Antioxidant And Radical Scavenging Activities In Fruits Of 6 Sea Buckthorn (Hippophae Rhamnoides L.) Cultivars, Otakar Rop, Sezai̇ Erci̇şli̇, Jiri Mlcek, Tunde Jurikova, Ignac Hoza
Turkish Journal of Agriculture and Forestry
Sea buckthorn (Hippophae rhamnoides L.) is a minor fruit crop. The most important breeding activities focused on the production of sea buckthorn fruits as a top-quality food product have been performed in Russia, Germany, and the Czech Republic. Over the past several decades, plant breeders have selected a number of cultivars that show excellent physical and nutritional properties. The aim of this study was to monitor and determine the total contents of phenols and flavonoids as well as antioxidant capacity and scavenging activity of methanolic extracts on reactive oxygen species and lipid peroxidation in some cultivars of sea buckthorn suitable …
The Choice Of Auxin Analogue For In Vitro Root Induction Influences Post-Induction Root Development In Eucalyptus Grandis, Muhammad Nakhooda, Maria Paula Watt, David Mycock
The Choice Of Auxin Analogue For In Vitro Root Induction Influences Post-Induction Root Development In Eucalyptus Grandis, Muhammad Nakhooda, Maria Paula Watt, David Mycock
Turkish Journal of Agriculture and Forestry
Previous studies on in vitro rooting for improved micropropagation of eucalypts indicated that root graviperception and post-acclimatisation architecture are determined by the relative exogenous auxin analogue and its stability, supplied during the pre-rooting culture stages. The specific roles of indole-3-acetic acid (IAA) and indole-3-butyric acid (IBA) in the rooting medium on the in vitro root morphological processes were explored using a good-rooting clone. In vitro rooting percentage was significantly reduced when either of the auxin inhibitors 2,3,5-triiodobenzoic acid (TIBA) and ρ-chlorophenoxyisobutyric acid (PCIB) or the auxin antagonist kinetin was supplied at rooting, with or without exogenous auxin. For all treatments, …
Genetic Comparison Between Natural And Planted Populations Of Pinus Brutia And Cupressus Sempervirens In Syria, Batoul N. Al-Hawija, Viktoria Wagner, Isabell Hensen
Genetic Comparison Between Natural And Planted Populations Of Pinus Brutia And Cupressus Sempervirens In Syria, Batoul N. Al-Hawija, Viktoria Wagner, Isabell Hensen
Turkish Journal of Agriculture and Forestry
There is wide consensus that ongoing deforestation contributes to global warming and poses a threat to species diversity. Less understood is whether the practice of creating plantations might also erode genetic diversity and undermine the genetic structure of tree populations. We tested these hypotheses in natural and planted populations of Pinus brutia Ten. subsp. brutia and Cupressus sempervirens L. var. horizontalis (Mill.), 2 important forestry species in the Mediterranean region. We used plant material from 3 different bioclimatic regions in Syria. Using RAPD markers, we evaluated the genetic diversity and structure of 12 populations of P. brutia (6 natural, 6 …
Plzf Overexpression In T-All Cell Line Cem-C7h2-2c8 Downregulates Glucocorticoid Receptor (Gr) And Its Target Genes, Muhammad Wasim, Muhammad Mansha, Muhammad Tayyab, Ali Raza Awan, Sehrish Firyal, Christine Mantinger, Tahir Yaqub
Plzf Overexpression In T-All Cell Line Cem-C7h2-2c8 Downregulates Glucocorticoid Receptor (Gr) And Its Target Genes, Muhammad Wasim, Muhammad Mansha, Muhammad Tayyab, Ali Raza Awan, Sehrish Firyal, Christine Mantinger, Tahir Yaqub
Turkish Journal of Biology
Glucocorticoids (GCs) induce cell cycle arrest and apoptosis in lymphoid cells and constitute a central component in the treatment of lymphoid malignancies. The molecular basis of this clinically important phenomenon remains, however, poorly understood. Using whole genome expression profiling we have previously identified glucocorticoid response genes in children with acute lymphoblastic leukemia (ALL). The promyelocytic leukemia zinc finger (PLZF) appeared as one of the most promising candidate genes, which has been implicated in the pathogenesis of several leukemia types. We have already established that transgenic PLZF reduced the sensitivity to GC-induced apoptosis in the CEM-C7H2-2C8 leukemic cell line and knockdown …
Concentration And Detection Of Tobacco Etch Virus From Irrigation Water Using Real-Time Pcr, Wei Chen, Jin Dai, Huawei Zhang, Honghong Jiao, Julong Cheng, Yunfeng Wu
Concentration And Detection Of Tobacco Etch Virus From Irrigation Water Using Real-Time Pcr, Wei Chen, Jin Dai, Huawei Zhang, Honghong Jiao, Julong Cheng, Yunfeng Wu
Turkish Journal of Agriculture and Forestry
Irrigation water can be polluted by the tobacco etch virus (TEV), which causes serious economic loss in tobacco. However, it is difficult to monitor the sanitary status of irrigation water because TEV presents at extremely low concentrations. This study designed a procedure for concentrating TEV from a standard water sample using polyethylene glycol and detecting it using SYBR Green-based quantitative real-time polymerase chain reaction (qRT-PCR). The concentration factors were optimized through orthogonal tests and the highest recovery efficiency of the TEV genome from a standard water sample was 92.05%. The sensitivity was evaluated using nine 10-fold dilution series of TEV …
Dry Matter Yield, Feeding Value, And Antioxidant Activity In Mediterranean Chicory (Cichorium Intybus L.) Germplasm, Giovanna Piluzza, Leonardo Sulas, Simonetta Bullitta
Dry Matter Yield, Feeding Value, And Antioxidant Activity In Mediterranean Chicory (Cichorium Intybus L.) Germplasm, Giovanna Piluzza, Leonardo Sulas, Simonetta Bullitta
Turkish Journal of Agriculture and Forestry
Knowledge about the forage yield potential and bioactive compound contents of Mediterranean natural populations of chicory is still scarce, even though it could be very helpful in view of the exploitation of the feeding value of local chicory germplasm for ruminants. Dry matter yield, chemical composition, antioxidant capacity, total polyphenols, flavonoids, and condensed tannins content were determined in 7 natural populations of Mediterranean wild chicory and, as a comparison, in the chicory commercial variety Spadona. Original seed was collected in different pastureland areas of Sardinia (Italy) and plants were grown in North Sardinia. Statistically significant differences were found in the …
Germination And Electrical Conductivity Tests On Artificially Aged Seed Lots Of 2 Wall-Rocket Species, Simona-Laura Lazar, Sara Mira, Doru Pamfil, Juan Bautista Martinez-Laborde
Germination And Electrical Conductivity Tests On Artificially Aged Seed Lots Of 2 Wall-Rocket Species, Simona-Laura Lazar, Sara Mira, Doru Pamfil, Juan Bautista Martinez-Laborde
Turkish Journal of Agriculture and Forestry
The aim of this study was to determine whether the loss of germinability and vigour in wall-rocket seed lots was related to electrolyte leakage. Ten seed lots of 2 wall-rocket species (9 of Diplotaxis tenuifolia and one of D. erucoides (Brassicaceae)) were stored at 45 °C and 70% relative humidity and electrolyte leakage was measured using the conductivity test. Small differences in longevity were found among species or seed lots, suggesting that a similar relative longevity might be expected within the genus Diplotaxis after artificial ageing, and that it will be above the average of that found in other species …
L-Arginine Impact On Cherry Rootstock Rooting And Biochemical Characteristics In Tissue Culture, Virginia Sarropoulou, Kortessa Dimassi-Theriou, Ioannis Therios
L-Arginine Impact On Cherry Rootstock Rooting And Biochemical Characteristics In Tissue Culture, Virginia Sarropoulou, Kortessa Dimassi-Theriou, Ioannis Therios
Turkish Journal of Agriculture and Forestry
In the present study, the effects of indole-3-butyric acid (IBA) separately and simultaneously with L-arginine on the morphogenic and biochemical responses in the cherry rootstocks CAB-6P (Prunus cerasus L.) and Gisela 6 (Prunus cerasus × Prunus canescens) were investigated. In the CAB-6P rootstock, the best root number and root length results were obtained with 2 mg L^{1} IBA plus 0.5 mg L^{1} L-arginine and 1 mg L^{1} IBA plus 1 mg L^{1} L-arginine, respectively. The rooting percentage was highest (100%) with 2 mg L^{1} IBA alone or combined with 1 mg L^{1} L-arginine. In the Gisela 6 explants, 2 mg …
Comparison Of Intraarticular Bupivacaine And Levobupivacaine Injection In Rat Synovial Inflammation, Beki̇r Suat Kürkçüoğlu, Melahat Dönmez, Seher Altinel, Seda Banu Akinci, Fatma Saricaoğlu, Ülkü Aypar
Comparison Of Intraarticular Bupivacaine And Levobupivacaine Injection In Rat Synovial Inflammation, Beki̇r Suat Kürkçüoğlu, Melahat Dönmez, Seher Altinel, Seda Banu Akinci, Fatma Saricaoğlu, Ülkü Aypar
Turkish Journal of Medical Sciences
Both bupivacaine and levobupivacaine are local anesthetics with strong analgesic efficacy that can be used intraarticularly. The aim of this study was to compare the effects of intraarticular bupivacaine and levobupivacaine injection on inflammation in articular cartilage and the synovium of the rat knee joint. Materials and methods: Twenty Sprague-Dawley rats were injected in the right knee joint with 0.2 mL of bupivacaine, while 0.2 mL of levobupivacaine was injected into the left knee joint. Groups of 5 were sacrificed on days 1, 7, 14, and 21 after bupivacaine and levobupivacaine administration and knee joints were examined for subintimal fibrosis, …
Effect Of Ginkgo Biloba On Brain Volume After Carotid Artery Occlusion In Rats: A Stereological And Histopathological Study, Zeynep Aktürk, Ersan Odaci, Ayşe İki̇nci̇, Orhan Baş, Si̇nan Canpolat, Serdar Çolakoğlu, Osman Fi̇kret Sönmez
Effect Of Ginkgo Biloba On Brain Volume After Carotid Artery Occlusion In Rats: A Stereological And Histopathological Study, Zeynep Aktürk, Ersan Odaci, Ayşe İki̇nci̇, Orhan Baş, Si̇nan Canpolat, Serdar Çolakoğlu, Osman Fi̇kret Sönmez
Turkish Journal of Medical Sciences
This study investigated the effect of Ginkgo biloba (GB) on brain volume in cerebral ischemia induced by stopping carotid artery blood flow. Materials and methods: Twenty-four adult male rats were divided into 4 groups of 6 rats each. No procedure was performed on the control group. Ischemia was applied to the rats in the ischemia and ischemia + GB groups by clamping the arteria carotis communis for 30 min. The rats in the ischemia + GB group were given 100 mg/kg drops (Tebokan Fort Drop, Abdi İbrahim İlaç Sanayi A.Ş., Turkey) containing dry GB leaf extract orally, every day for …
Comparison Of Hippocampal Interleukin-6 Immunoreactivity After Exhaustive Exercise In Both Exercise-Trained And Untrained Rats, Lati̇fe Arzu Aral, Lamia Pinar, Güleser Göktaş, Elçi̇n Yaşar Deveden, Deni̇z Erdoğan
Comparison Of Hippocampal Interleukin-6 Immunoreactivity After Exhaustive Exercise In Both Exercise-Trained And Untrained Rats, Lati̇fe Arzu Aral, Lamia Pinar, Güleser Göktaş, Elçi̇n Yaşar Deveden, Deni̇z Erdoğan
Turkish Journal of Medical Sciences
Exhaustive exercise is a strong stress factor and can impact cytokine production in the brain. Interleukin-6 (IL-6) is produced in greater amounts than any other cytokine in response to exercise, and its effects are closely related to both exercise duration and intensity. In this study, we measured the differences between the amount of IL-6 reactivity of the hippocampus after an exhaustive session of running in long-term exercise-trained and untrained rats. Materials and methods: The exercise-trained group ran on a treadmill for 12 weeks. Both groups were forced to run until exhaustion. Each group of rats was sacrificed immediately, 1 day, …
The Role Of Hepcidin And Its Related Genes (Bmp6, Gdf-15, And Hjv) In Rats Exposed To Ischemia And Reperfusion, Recep Dokuyucu, Tuncer Demi̇r, Önder Yumrutaş, Ayşe Bi̇nnur Erbağci, Mustafa Örkmez, Abdulkadi̇r Yasi̇r Bahar, Recep Bayraktar, İbrahi̇m Bozgeyi̇k, Davut Si̇nan Kaplan, Beyhan Cengi̇z, Cahi̇t Bağci
The Role Of Hepcidin And Its Related Genes (Bmp6, Gdf-15, And Hjv) In Rats Exposed To Ischemia And Reperfusion, Recep Dokuyucu, Tuncer Demi̇r, Önder Yumrutaş, Ayşe Bi̇nnur Erbağci, Mustafa Örkmez, Abdulkadi̇r Yasi̇r Bahar, Recep Bayraktar, İbrahi̇m Bozgeyi̇k, Davut Si̇nan Kaplan, Beyhan Cengi̇z, Cahi̇t Bağci
Turkish Journal of Medical Sciences
To determine the roles of hepcidin and its related genes in a renal ischemia/reperfusion model. Materials and methods: A total of 20 Wistar albino rats were equally divided into 2 groups: Group I was the control group and Group II was the ischemia and reperfusion (I/R) group (60 min of ischemia + 48 h of reperfusion). I/R was performed on the left kidneys of these rats and then the I/R-treated kidneys were removed. The levels of serum biochemical markers were evaluated after renal I/R. The expression levels of hepcidin-linked genes [growth differentiation factor 15 (GDF-15), bone morphogenetic protein 6 (BMP6), …
Hormone Replacement Therapy-Related Changes In The Early Postmenopausal Period (Critical Window): An In Vivo Brain Proton Magnetic Resonance Spectroscopy Study, Kamran Mahmutyazicioğlu, Fahri̇ Hali̇t Beşi̇r, Mustafa Bardakçi, Hami̇t Alper Tanriverdi̇, Handan Ankarali
Hormone Replacement Therapy-Related Changes In The Early Postmenopausal Period (Critical Window): An In Vivo Brain Proton Magnetic Resonance Spectroscopy Study, Kamran Mahmutyazicioğlu, Fahri̇ Hali̇t Beşi̇r, Mustafa Bardakçi, Hami̇t Alper Tanriverdi̇, Handan Ankarali
Turkish Journal of Medical Sciences
Findings from clinical studies in postmenopausal women with late initiation of hormone replacement therapy (HRT) that test whether HRT protects cognitive functions in women are inconsistent. The aim of this study was to investigate the effects of HRT on brain metabolite ratios when initiated in the early postmenopausal period (critical window). Materials and methods: Proton magnetic resonance spectrometry (1H MRS) was performed in 4 brain regions of 47 healthy postmenopausal women (21 received HRT, 26 did not). The subjects were aged between 45 and 65 years. The duration of HRT ranged from 1 to 12 years (mean: 6.3 years). The …
Evaluation Of Apoptotic Cell Death Following Transient Maternal Hypotension In Fetal Rat Brain: Temporal Pattern Within The First 24 H After Procedure, Si̇bel Bayrak, Bi̇lge Pehli̇vanoğlu, Ayşe Meltem Sevgi̇li̇, Zeynep Di̇cle Balkanci, Hami̇t Özyürek, Pergi̇n Ati̇lla, Ayşe Nur Çakar, Fatma Banu Anlar
Evaluation Of Apoptotic Cell Death Following Transient Maternal Hypotension In Fetal Rat Brain: Temporal Pattern Within The First 24 H After Procedure, Si̇bel Bayrak, Bi̇lge Pehli̇vanoğlu, Ayşe Meltem Sevgi̇li̇, Zeynep Di̇cle Balkanci, Hami̇t Özyürek, Pergi̇n Ati̇lla, Ayşe Nur Çakar, Fatma Banu Anlar
Turkish Journal of Medical Sciences
To explore the effects of maternal transient systemic hypotension on apoptotic neuronal death in an intrauterine fetal rat brain during the first 24 h after induction of hypotension. Materials and methods: A total of 40 pregnant SpragueDawley rats were subjected to either transient systemic hypotension produced for 30 min by blood withdrawal via femoral artery catheterization (hypotension group) or sham operation (control group) on day 15. Two randomly selected fetuses were taken from each rat at 0, 6, 12, and 24 h after the procedure. Apoptosis was evaluated in sections from the whole fetal brain by TUNEL and caspase-3 staining. …
Behavioural And Neurobiological Consequences Of 2 Different Chronic Stressors In Rats, Refi̇a Aslihan Dönmez, Fatma Duygu Kaya, Okşan Deri̇nöz, Ömer Hakan Emmez, Selçuk Candansayar, Hayrunni̇sa Bolay Belen
Behavioural And Neurobiological Consequences Of 2 Different Chronic Stressors In Rats, Refi̇a Aslihan Dönmez, Fatma Duygu Kaya, Okşan Deri̇nöz, Ömer Hakan Emmez, Selçuk Candansayar, Hayrunni̇sa Bolay Belen
Turkish Journal of Medical Sciences
To compare the behavioural and neurobiological consequences of chronic headache and chronic mild stress (CMS) in rats. Materials and methods: Forty-eight male Wistar rats were divided into 4 groups: 1) control group, 2) chronic headache group, 3) CMS group, and 4) sham group. Their behaviour prior to (D0) and after (D14) chronic stress was analysed. Afterwards, they were exposed to the Elevated Plus Maze (EPM) in order to evaluate anxiety-like behaviour and the Forced Swim Test (FST) for observation of depressive-like behaviour. Ultrasonic vocalisations (USVs) were recorded by a USV detector system at D0 and D14 and during the FST. …
Protective Role Of Caffeic Acid Phenethyl Ester On Serum Cholinesterase Inhibition By Acute Exposure To Diazinon In Rats, Esi̇n Oğuzhanoğlu, Ahmet Cenk Andaç, Adnan Tüfek, Lütfi̇ Yavuz, Hüseyi̇n Vural, Osman Gökalp
Protective Role Of Caffeic Acid Phenethyl Ester On Serum Cholinesterase Inhibition By Acute Exposure To Diazinon In Rats, Esi̇n Oğuzhanoğlu, Ahmet Cenk Andaç, Adnan Tüfek, Lütfi̇ Yavuz, Hüseyi̇n Vural, Osman Gökalp
Turkish Journal of Medical Sciences
To evaluate whether caffeic acid phenethyl ester (CAPE), a flavonoid-like natural compound plentifully found in beeswax, has a protective effect on diazinon-induced serum cholinesterase (ChE) inhibition in rats. Materials and methods: Animals were divided into 4 groups. The first animal group was not treated with any substance. The second animal group was orally given a 200 mg/kg body weight (bw) sublethal dose of diazinon. The third animal group was injected intraperitoneally with 2.84 mg (10 µmol)/kg bw of CAPE 1 day prior to administration of 200 mg/kg bw of diazinon orally. The fourth animal group was intraperitoneally injected with 2.84 …
New Hemostatic Agent: The Effect Of Ankaferd Blood Stopper On Healing Wounds In Experimental Skin Incision Model, Serdar Yüce, Celal Çandirli, Si̇bel Yeni̇dünya, Bünyami̇n Muslu
New Hemostatic Agent: The Effect Of Ankaferd Blood Stopper On Healing Wounds In Experimental Skin Incision Model, Serdar Yüce, Celal Çandirli, Si̇bel Yeni̇dünya, Bünyami̇n Muslu
Turkish Journal of Medical Sciences
To conduct a histopathological evaluation of the effects of Ankaferd Blood Stopper (ABS) on healing wounds in a rabbit skin incision model. Materials and methods: Incisions were performed on the backs of rabbits. The first incision was allowed to undergo normal secondary healing. ABS (1 mL) was applied to the second incision, which was subsequently allowed to undergo secondary healing. The third incision was sutured. ABS (1 mL) was applied to the fourth incision, which was subsequently sutured. During the wound healing period, the histopathologic signs of ulceration, inflammation, the proliferative phase, and the extent of early remodeling were comparatively …
Comparison Of The Efficacy Of Prednisolone, Montelukast, And Omalizumab In An Experimental Allergic Rhinitis Model, Mete Kaan Bozkurt, Baykal Tülek, Banu Bozkurt, Nalan Akyürek, Mehmet Öz, Aysel Kiyici
Comparison Of The Efficacy Of Prednisolone, Montelukast, And Omalizumab In An Experimental Allergic Rhinitis Model, Mete Kaan Bozkurt, Baykal Tülek, Banu Bozkurt, Nalan Akyürek, Mehmet Öz, Aysel Kiyici
Turkish Journal of Medical Sciences
To compare the efficacy of prednisolone, montelukast, and omalizumab in reducing allergic symptoms and inflammation at tissue level in an experimental allergic rhinitis model. Materials and methods: Forty Sprague Dawley rats were randomized into 5 groups as naive (NS/NC), sensitized/challenged (S/C) by subcutaneous ovalbumin antigen injection, and montelukast-, prednisolone-, and omalizumab-treated groups. A nasal allergen challenge was performed every day from day 20 to day 26. The number of sneezes and nasal/eye rubbing movements, IL-4 and CysLT levels in serum, nasal and bronchoalveolar lavage fluids determined by ELISA, and histopathological findings of nasal mucosa, sinus, and lung tissues were compared. …
Protective Effect Of L-Carnitine In A Rat Model Of Retinopathy Of Prematurity, Sadullah Keleş, İbrahi̇m Caner, Orhan Ateş, Özgür Çakici, Fati̇h Saruhan, Uğur Yilmaz Mumcu, Deni̇z Ünal, Kadi̇r Şerafetti̇n Tekgündüz, Ayhan Taşteki̇n, Ahmet Hacimüftüoğlu, Nesri̇n Gürsan, Hami̇t Hakan Alp
Protective Effect Of L-Carnitine In A Rat Model Of Retinopathy Of Prematurity, Sadullah Keleş, İbrahi̇m Caner, Orhan Ateş, Özgür Çakici, Fati̇h Saruhan, Uğur Yilmaz Mumcu, Deni̇z Ünal, Kadi̇r Şerafetti̇n Tekgündüz, Ayhan Taşteki̇n, Ahmet Hacimüftüoğlu, Nesri̇n Gürsan, Hami̇t Hakan Alp
Turkish Journal of Medical Sciences
To investigate the effects of L-carnitine (LC) on rats with oxygen-induced retinopathy. Materials and methods: The study was conducted on 40 Sprague Dawley rat pups. The rat pups were randomly divided into 4 groups: group 1 (n = 10), the healthy control group with intraperitoneal 0.1 mL/day physiological saline injection; group 2 (n = 10), exposed to hyperoxygen, did not receive LC but received 0.1 mL/day physiological saline intraperitoneally; group 3 (n = 10), exposed to hyperoxygen and received 100 mg/kg/day LC intraperitoneally; group 4 (n = 10), exposed to hyperoxygen and received 200 mg/kg/day LC intraperitoneally. After postnatal day …
The Frequency Of Human Papillomaviruses In Colorectal Cancer Samples In Mashhad, Northeastern Iran, Mojtaba Meshkat, Naser Tayyebi Meibodi, Samaneh Sepahi, Narges Fadaee, Masoumeh Salehpour, Zahra Meshkat
The Frequency Of Human Papillomaviruses In Colorectal Cancer Samples In Mashhad, Northeastern Iran, Mojtaba Meshkat, Naser Tayyebi Meibodi, Samaneh Sepahi, Narges Fadaee, Masoumeh Salehpour, Zahra Meshkat
Turkish Journal of Medical Sciences
Infection with the human papillomaviruses (HPVs) is associated with the development of several cancers, including oral, esophageal, skin, lung, and cervical. However, the association of HPVs and colorectal cancers remains controversial. The aim of this study was to evaluate the association between HPV infection and paraffin-embedded colorectal tissue samples in Mashhad in the northeast of Iran. Materials and methods: Paraffin-embedded tissue specimens from 111 patients with colorectal cancer were subjected to DNA extraction. The quality of extracted DNA was confirmed by amplification of a b-globin fragment using polymerase chain reaction (PCR) and GH20/PCO4 primers. PCR with GP5+/GP6+ primers was then …
Maternal Embryokines That Regulate Development Of The Bovine Preimplantation Embryo, Peter James Hansen, Anna Carolina Denicol, Kyle Bradley Dobbs
Maternal Embryokines That Regulate Development Of The Bovine Preimplantation Embryo, Peter James Hansen, Anna Carolina Denicol, Kyle Bradley Dobbs
Turkish Journal of Veterinary & Animal Sciences
Proper embryonic development depends upon regulatory signals from the reproductive tract called embryokines. This review uses the cow as a model to understand the developmental processes controlled by embryokines. The focus is on 3 embryokines that have been shown to increase competence of embryos to survive after transfer to recipients: CSF2, IGF1, and DKK1. Together, these molecules regulate key events required for development of the embryo to the blastocyst stage including proliferation (enhanced by IGF1), development of the inner cell mass (regulated by CSF2), control of differentiation (modified by DKK1), and inhibition of apoptosis and stress-mediated developmental arrest (IGF1 and …
Recent Advances In The Immunology And Uterine Microbiology Of Healthy Cows And Cows That Develop Uterine Disease, Klibs N. Galvao, Jose Eduardo P. Santos
Recent Advances In The Immunology And Uterine Microbiology Of Healthy Cows And Cows That Develop Uterine Disease, Klibs N. Galvao, Jose Eduardo P. Santos
Turkish Journal of Veterinary & Animal Sciences
Uterine diseases are highly prevalent in dairy cows. Causes of uterine diseases are multifactorial. There is good evidence for the susceptibility of the host and for the role of pathogenic bacteria, and less evidence for the effect of the environment. Uterine and leukocyte immune response is impaired early postpartum in cows that develop uterine disease. The decrease in immune function is associated with a decrease in calcium postpartum and an increase in NEFA and BHBA. Both endometrial cells and granulosal cells possess toll-like receptors (TLR) that can recognize and mount an inflammatory response to pathogen-associated molecular patterns (PAMPs) such as …
Genetic Characterization Of Paramphistomes Of Buffalo By Hat-Rapd Analysis, Giregowdanahalli Puttalakshmamma, Umed Ramani, Krishna Singh, Amrutlal Patel, Abdul Patel, Chaitanya Joshi
Genetic Characterization Of Paramphistomes Of Buffalo By Hat-Rapd Analysis, Giregowdanahalli Puttalakshmamma, Umed Ramani, Krishna Singh, Amrutlal Patel, Abdul Patel, Chaitanya Joshi
Turkish Journal of Veterinary & Animal Sciences
Paramphistomosis is widely prevalent in domestic farm animals, incurring heavy economic losses in several countries across the world. As the identification of these parasites based on morphological features is very difficult, molecular characterization is necessary to discriminate among different species. We performed polymorphic DNA fingerprint analysis of 3 different species of amphistomes collected from the rumen and bile ducts of buffaloes slaughtered at a local abattoir in Anand, Gujarat, India. The ruminal amphistomes were identified as Paramphistomum cervi and Gastrothylax indicus, while the hepatic amphistomes were identified as Gigantocotyle bathycotyle. High annealing temperature-random amplified polymorphic DNA (HAT-RAPD) analysis with 4 …