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Effects Of Roasting And Enzyme Pretreatments On Yield And Quality Of Cold-Pressed Poppy Seed Oils, Di̇lek Dündar Emi̇r, Buket Aydeni̇z, Emi̇n Yilmaz
Effects Of Roasting And Enzyme Pretreatments On Yield And Quality Of Cold-Pressed Poppy Seed Oils, Di̇lek Dündar Emi̇r, Buket Aydeni̇z, Emi̇n Yilmaz
Turkish Journal of Agriculture and Forestry
The aim of this study was to compare the effects of roasting and enzyme pretreatments on the yield and quality of cold-pressed oils obtained from 3 poppy seed varieties (Ofis 3 (blue), Ofis 4 (yellow), Ofis 8 (white)). The oil recovery range was 21.89%-38.36% with cold pressing. The oily cakes (meal) contained 42-168 g/kg oil and 113-166.3 g/kg moisture after the cold pressing. Physicochemical and quality tests were conducted to evaluate and compare the efficacy of the pretreatments. Furthermore, fatty acid, sterol, and tocopherol compositions were determined. Oil recovery was enhanced by enzyme treatment in Ofis 3 (28.31%) and Ofis …
Mitochondrial Dna-Related Disorders: Emphasis On Mechanisms And Heterogeneity, Umut Cagin, Jose Antonio Enriquez
Mitochondrial Dna-Related Disorders: Emphasis On Mechanisms And Heterogeneity, Umut Cagin, Jose Antonio Enriquez
Turkish Journal of Biology
Mitochondrial diseases are a heterogeneous group of disorders that are currently the focus of intense research. The many cell functions performed by mitochondria include ATP production, calcium homeostasis, and apoptosis. One of the unique properties of mitochondria is the existence of a separate mitochondrial genome (mitochondrial DNA, mtDNA) found in varying copy numbers and containing 37 genes, 13 of them encoding proteins. All 13 mitochondrially encoded proteins form part of oxidative phosphorylation complexes through combination with approximately 100 nuclear DNA-encoded proteins. Coregulation of nDNA and mtDNA is therefore essential for mitochondrial function, and this coregulation contributes to the heterogeneity and …
The Effects Of Midazolam And Etomidate On The Antioxidant System In The Rat Liver, Di̇lek Bayram, Meral Öncü, Efkan Uz, Haci Ramazan Yilmaz, Ayşe Yi̇ği̇t, Ahmet Koçak
The Effects Of Midazolam And Etomidate On The Antioxidant System In The Rat Liver, Di̇lek Bayram, Meral Öncü, Efkan Uz, Haci Ramazan Yilmaz, Ayşe Yi̇ği̇t, Ahmet Koçak
Turkish Journal of Biology
This study was conducted to investigate the histopathological and biochemical effects of midazolam and etomidate, which are intravenous anesthetics used in surgical operations, on rat liver. There were 3 study groups each consisting of 9 animals: the control, midazolam, and etomidate groups. Midazolam and etomidate were administered 10 times with 1-day intervals. At the end of the study, tissues were taken for histological examination and biochemical analysis. We determined superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels in the liver. There was a slight increase in MDA level in the midazolam-exposed group when compared with the controls, and this …
The Response To Bacterial Inoculation Is Cultivar-Related In Strawberries, Jelena M. Tomic, Jasminka M. Milivojevic, Marijana I. Pesakovic
The Response To Bacterial Inoculation Is Cultivar-Related In Strawberries, Jelena M. Tomic, Jasminka M. Milivojevic, Marijana I. Pesakovic
Turkish Journal of Agriculture and Forestry
This study was carried out to evaluate the impact of biofertilizer and cultivar on vegetative potential (height of the plant, number of crowns and leaves per plant, and the area of a single leaf), leaf mineral composition (micro- and macroelements), yield potential (number of inflorescences and fruit set per plant, yield per plant, and yield per square meter), fruit characteristics (mass, length, width, and fruit shape index), and chemical traits (soluble solids content, titratable acidity (TA), vitamin C, total anthocyanins (TACY), total phenolic content (TPC), and total antioxidant capacity (TAC)) in the fruits of Clery, Joly and Dely strawberry plants. …
The Effects Of Topical Melatonin On Oxidative Stress, Apoptosis Signals,And P53 Protein Expression During Cutaneous Wound Healing, Azi̇ze Şener, Özge Çevi̇k, Özge Doğan, Nazli Gül Altindi̇ş, Hali̇l Aksoy, Betül Okuyan
The Effects Of Topical Melatonin On Oxidative Stress, Apoptosis Signals,And P53 Protein Expression During Cutaneous Wound Healing, Azi̇ze Şener, Özge Çevi̇k, Özge Doğan, Nazli Gül Altindi̇ş, Hali̇l Aksoy, Betül Okuyan
Turkish Journal of Biology
Elimination of reactive oxygen species (ROS) can be an important strategy to improve healing of wounds. ROS have an effect on proliferation and cell survival signaling, which results in alteration of apoptotic pathways in cells. Melatonin has antioxidant properties on skin wounds. In our study, we investigated the effects of topical melatonin (3%, w/w) on apoptosis and p53 protein expression together with parameters of oxidative stress in a cutaneous excision wound model. Bcl-2 protein levels in wound tissue at the end of days 3, 7, and 14 were significantly increased, while caspase-3 activity and p53 protein expression in wound tissue …
Simulation Of Forest Harvesting Alternative Processes And Concept Design Ofan Innovative Skidding Winch Focused On Productivity Improvement, Giuseppe Di Gironimo, Alessio Balsamo, Gianpiero Esposito, Antonio Lanzotti, Kenan Melemez, Raffaele Spinelli
Simulation Of Forest Harvesting Alternative Processes And Concept Design Ofan Innovative Skidding Winch Focused On Productivity Improvement, Giuseppe Di Gironimo, Alessio Balsamo, Gianpiero Esposito, Antonio Lanzotti, Kenan Melemez, Raffaele Spinelli
Turkish Journal of Agriculture and Forestry
In contexts in which mechanized harvesting is limited, such as in the northwestern Black Sea region of Turkey, it is important to improve timber harvesting productivity while preserving operators' safety and reducing environmental damage. This study aims to introduce a methodology in which the harvesting process is simulated with discrete-event simulation (DES) software in order to identify bottlenecks. An alternative process is compared to the original within the DES software, carrying out further steps oriented to the generation of new innovative product concepts. As a case study, the design of an innovative skidding winch is proposed. The development of the …
Major Quantitative Trait Loci For Flowering Time In Lentil, Abdullah Kahri̇man, Hülya Yilmaz Temel, Abdulkadi̇r Aydoğan, Muhammed Bahatti̇n Tanyolaç
Major Quantitative Trait Loci For Flowering Time In Lentil, Abdullah Kahri̇man, Hülya Yilmaz Temel, Abdulkadi̇r Aydoğan, Muhammed Bahatti̇n Tanyolaç
Turkish Journal of Agriculture and Forestry
Quantitative trait loci (QTLs) for flowering time (FT) in lentil were located using a recombinant inbreed line population derived from an intraspecific cross of Precoz × WA8649041. Experiments for FT were conducted in 2 locations (Haymana, Turkey and Pullman, WA, USA) for 5 years (from 1998 to 2002 in both Pullman and Haymana). A linkage map was constructed using 149 markers (RAPD, AFLP, ISSR, SSR, and 2 morphological markers) located on 11 linkage groups (LGs). Analysis of variance of FT was found to be significant for all locations and years. One major QTL for FT was identified on LG6 across …
Aquaporins As Targets For Stress Tolerance In Plants: Genomic Complexity And Perspectives, Wonkeun John Park, Benjamin Todd Campbell
Aquaporins As Targets For Stress Tolerance In Plants: Genomic Complexity And Perspectives, Wonkeun John Park, Benjamin Todd Campbell
Turkish Journal of Botany
As a multigene family, plant aquaporins function not only in water transport but also in transport of small elements that are important for vegetative and reproductive growth of plants. Increasing evidence exhibits the relevance of aquaporins to tolerance against abiotic and biotic stresses such as drought, nutrient deficiency, and herbivore attack. With the accumulation of crop genome sequencing, it is suggested that several aquaporin genes are conserved in subchromosomal locations as tandem duplicated members. In this review, we will discuss the compelling nature of aquaporins as multifunctional transport channels that are often encoded in clustered regions of genomes and relevant …
Application Of Data Analysis In Cold Stress: A Case Study Of Nicotiana Benthamiana, İbrahi̇m Koç, Zi̇hni̇ Onur Çalişkaner, Ertuğrul Fi̇li̇z
Application Of Data Analysis In Cold Stress: A Case Study Of Nicotiana Benthamiana, İbrahi̇m Koç, Zi̇hni̇ Onur Çalişkaner, Ertuğrul Fi̇li̇z
Turkish Journal of Botany
Cold stress is a major environmental factor in plant life cycles. Nicotiana benthamiana, which belongs to the family Solanaceae, is one of the most commonly used model species in plant-microbe interaction studies. In total, 5205 differentially expressed genes were identified under cold stress in N. Benthamiana. Of these, 5029 were upregulated and 176 were downregulated within four time periods (4 h, 12 h, 24 h, and 48 h). The common up- and downregulated genes were identified as 692 and 6, respectively. The functional annotations of these genes were studied and these common genes involved in protein, RNA, miscellaneous enzyme families, …
Identification And Analysis Of Regulatory Elements In The Germin And Germin-Like Proteins Family Promoters In Rice, Iftikhar Ali, Tariq Mahmood
Identification And Analysis Of Regulatory Elements In The Germin And Germin-Like Proteins Family Promoters In Rice, Iftikhar Ali, Tariq Mahmood
Turkish Journal of Botany
Germins and germin-like proteins constitute a ubiquitous family of plant proteins and have a role in the defense against pathogen attacks. In the present work the Oryza sativa germin-like protein 1 (OsGLP1) and putative germin A (OsGerA) promoter regions of five Pakistani rice varieties were analyzed for variations in expression regulation of these promoters and similarity with others germin and germin-like protein promoters. Phylogenetic analyses showed that the studied OsGLP1 promoters were tightly clustered around the ancestral group while putative OsGerA clustered around the descendant group. HADDOCK was used for docking selected transcription factors (TFs) with its corresponding regulatory elements, …
Protective Effects Of Erdosteine, Vitamin E, And Vitamin C On Renal Injury Induced By The Ischemia-Reperfusion Of The Hind Limbs In Rats, Rana Sirmali, Abdullah Armağan, Faruk Öktem, Efkan Uz, Aynur Kirbaş, Soner Dönmez, Haci Ramazan Yilmaz, Mesrur Selçuk Silay, Mehmet Sirmali
Protective Effects Of Erdosteine, Vitamin E, And Vitamin C On Renal Injury Induced By The Ischemia-Reperfusion Of The Hind Limbs In Rats, Rana Sirmali, Abdullah Armağan, Faruk Öktem, Efkan Uz, Aynur Kirbaş, Soner Dönmez, Haci Ramazan Yilmaz, Mesrur Selçuk Silay, Mehmet Sirmali
Turkish Journal of Medical Sciences
To compare the protective efficacy of erdosteine and vitamins C and E against renal injury caused by hind limb ischemia-reperfusion (I/R). Materials and methods: Rats were split into 4 groups: group I as the control, group II as I/R, group III as I/R + erdosteine, and group IV as I/R + vitamins C and E. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) tissue levels were determined. Results: MDA levels were found comparable with the control group in groups II and III. However, they were considerably decreased in group IV when compared to group II …
A Molecular Epidemiological Investigation Of Multistate Outbreaks Of Salmonella Enteritidis From Clinical And Environmental Samples In Turkey, 2000-2010, Sümeyra Acar, Belkis Levent, Ekrem Atalan
A Molecular Epidemiological Investigation Of Multistate Outbreaks Of Salmonella Enteritidis From Clinical And Environmental Samples In Turkey, 2000-2010, Sümeyra Acar, Belkis Levent, Ekrem Atalan
Turkish Journal of Medical Sciences
To analyze interrelated Salmonella Enteritidis strains isolated in Turkey. Fifty-five S. Enteritidis surveillance strains were isolated from human feces and environmental samples from different regions in Turkey between 2000 and 2010. Materials and methods: Clinical isolates were selected from different outbreaks in the Turkish National Reference Laboratory. All isolates were submitted to antimicrobial susceptibility test, plasmid profile analysis, and XbaI-digested pulsed-field gel electrophoresis. Results: The strains were scanned against 20 antibiotics and for 3 of them (amikacin, ciprofloxacin, gentamicin), all strains were found to be sensitive. Five isolates had no plasmid. Most of test strains carried the 57-kb plasmid in …
The Effect Of Extracorporeal Shock Wave Lithotripsy On Distribution Of Interstitial Cells Of Cajal In Rabbit Renal Pelvis And Proximal Ureter, Özlem Boybeyi̇, Mi̇ne Fedakar Şenyücel, Ebru Şebnem Ayva, Tutku Soyer, Mustafa Kemal Aslan, Mehmet Murad Başar, Ahmet Murat Çakmak
The Effect Of Extracorporeal Shock Wave Lithotripsy On Distribution Of Interstitial Cells Of Cajal In Rabbit Renal Pelvis And Proximal Ureter, Özlem Boybeyi̇, Mi̇ne Fedakar Şenyücel, Ebru Şebnem Ayva, Tutku Soyer, Mustafa Kemal Aslan, Mehmet Murad Başar, Ahmet Murat Çakmak
Turkish Journal of Medical Sciences
An experimental study was performed to evaluate the effect of extracorporeal shock wave lithotripsy (ESWL) on the distribution of interstitial cells of Cajal (ICC) in rabbit renal pelvis and proximal ureter. Materials and methods: Six New Zealand rabbits were included. Right kidneys were exposed to a total of 3000 shock waves (14 kV) by using an electrohydraulic-type ESWL device. Right sides were allocated as the ESWL group (EG, n = 6) and left sides as the control group (CG, n = 6). Tissues were harvested on day 7. Tissues were examined histopathologically for the presence of edema, inflammation, congestion, hemorrhage, …
Effect Of Keratinocyte Growth Factor On Growth And Transdifferentiationof Primary Alveolar Epithelial Type Ii Cells, Xiuxiang Liu, Zhichun Feng, Chunmei Tian, Xiangyong Kong, Yumei Wu, Changjun Lv
Effect Of Keratinocyte Growth Factor On Growth And Transdifferentiationof Primary Alveolar Epithelial Type Ii Cells, Xiuxiang Liu, Zhichun Feng, Chunmei Tian, Xiangyong Kong, Yumei Wu, Changjun Lv
Turkish Journal of Medical Sciences
Background/aim: To investigate the effects of keratinocyte growth factor (KGF) on the growth and transdifferentiation of primary alveolar epithelial type II cells (AECIIs). Materials and methods: The number of primary AECIIs, their viability, and cell cycle and apoptosis were studied under KGF treatment using a hemocytometer, trypan blue exclusion, and flow cytometry, respectively. Positive expressions of surfactant protein C (SP-C), aquaporin 5 (AQP5), and thyroid transcription factor 1(TTF-1) were examined with indirect immunofluorescence; mRNA levels of SP-C, AQP5, and TTF-1 were determined by polymerase chain reaction. Results: In response to KGF treatment, cell numbers were significantly increased, more cells were …
Protective Effect Of \Beta-Glucan On Acute Lung Injury Induced Bylipopolysaccharide In Rats, Meryem Iraz, Mustafa Iraz, Mukaddes Eşrefoğlu, Mehmet Şeri̇f Aydin
Protective Effect Of \Beta-Glucan On Acute Lung Injury Induced Bylipopolysaccharide In Rats, Meryem Iraz, Mustafa Iraz, Mukaddes Eşrefoğlu, Mehmet Şeri̇f Aydin
Turkish Journal of Medical Sciences
Background/aim: Lipopolysaccharide (LPS)-induced endotoxemia can cause serious organ damage such as acute lung injury and death by triggering the secretion of proinflammatory cytokines and acute-phase reactants. The goal of this study was to evaluate the effects of \beta-glucan on inflammatory mediator levels and histopathological changes in LPS-induced endotoxemia. Materials and methods: Forty-seven male Wistar albino rats were randomly allocated into four groups as follows: control group, LPS group (10 mg/kg LPS), LPS + \beta-glucan group (100 mg/kg \beta-glucan before LPS administration), and \beta-glucan group. Twelve hours after LPS administration, lung and serum samples were collected. Concentrations of IL-6, IL-8, C-reactive …
Vitamin E Modulates Lung Oxidative Stress, Serum Copper, Zinc, And Iron Levels In Rats With Pulmonary Contusion, Mehmet Sirmali, Okan Solak, Tali̇p Çevi̇k, Rana Sirmali, Bünyami̇n Özaydin, Zeynep Gi̇ni̇ş, Yetki̇n Ağaçkiran, Namik Deli̇baş
Vitamin E Modulates Lung Oxidative Stress, Serum Copper, Zinc, And Iron Levels In Rats With Pulmonary Contusion, Mehmet Sirmali, Okan Solak, Tali̇p Çevi̇k, Rana Sirmali, Bünyami̇n Özaydin, Zeynep Gi̇ni̇ş, Yetki̇n Ağaçkiran, Namik Deli̇baş
Turkish Journal of Medical Sciences
To evaluate the effects of oxidant/antioxidant mechanisms and levels of trace elements on trauma-stimulated moderate pulmonary contusions after vitamin E administration. Materials and methods: Sixty-three male Sprague Dawley rats were used. Animals were studied in 4 groups. Vitamin E (150 mg/kg) was injected intraperitoneally 30 min after trauma and on the first and second days. Blood samples were obtained for nitric oxide (NO) levels and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities. Zinc (Zn^{+2}), copper (Cu^{+2}), and iron (Fe^{+3}) were measured in serum. Results: Lung contusion increased serum and tissue NO levels and SOD activities and decreased GSH-Px activities …
The First Ptpn11 Mutations In Hotspot Exons Reported In Moroccan Children With Noonan Syndrome And Comparison Of Mutation Rate To The Previous Studies, Ihssane El Bouchikhi, Imane Samri, Mohammed Iraqui Houssaini, Saaid Trhanint, Laila Bouguenouch, Hanane Sayel, Moustapha Hida, Samir Atmani, Karim Ouldim
The First Ptpn11 Mutations In Hotspot Exons Reported In Moroccan Children With Noonan Syndrome And Comparison Of Mutation Rate To The Previous Studies, Ihssane El Bouchikhi, Imane Samri, Mohammed Iraqui Houssaini, Saaid Trhanint, Laila Bouguenouch, Hanane Sayel, Moustapha Hida, Samir Atmani, Karim Ouldim
Turkish Journal of Medical Sciences
Background/aim: Noonan syndrome is an autosomal dominant disorder with an incidence of 1/1000?2500. It results from protein-tyrosine phosphatase, nonreceptor type 11 (PTPN11) mutations in roughly 50% of cases. Mutational screening of PTPN11 has been carried out in different populations. Thus, the aim of this study was to screen, for the first time, PTPN11 mutations in a series of Moroccan Noonan syndrome patients. Materials and methods: We used bidirectional sequencing of exons 3 and 8, considered as PTPN11 mutation hot spots, and then compared the rate of mutational events of these exons between different populations using chi-square and Fisher?s exact tests. …
Hemodynamic Effects Of Atrial Natriuretic Peptide In Ischemia-Reperfusioninjury That Occurs After Exercise, Selma Arzu Vardar, Orki̇de Palabiyik, Ruhan Deni̇z Topuz, Eli̇f Ezgi̇ Gürel, Semra Çalişkan, Serap Topcu Özen, Necdet Süt, Çeti̇n Hakan Karadağ
Hemodynamic Effects Of Atrial Natriuretic Peptide In Ischemia-Reperfusioninjury That Occurs After Exercise, Selma Arzu Vardar, Orki̇de Palabiyik, Ruhan Deni̇z Topuz, Eli̇f Ezgi̇ Gürel, Semra Çalişkan, Serap Topcu Özen, Necdet Süt, Çeti̇n Hakan Karadağ
Turkish Journal of Medical Sciences
Atrial natriuretic peptide (ANP) is known as a protective agent against ischemia-reperfusion injury for cardiomyocytes. We compared the hemodynamic effects of ANP and isatin, which is known as an ANP receptor blocker, in ischemia followed by reperfusion in exercised rat hearts with nonexercised ones. Materials and methods: Isolated hearts were perfused in 4 exercised (E) groups after a running protocol for 5 days and 4 nonexercised (NE) groups. In the first protocol, ANP was added to the perfusion solution before ischemia in an E and NE group. In the second protocol, different doses of isatin (0.1, 10, 100 µM/L) were …
Premarital Screening Of 466 Mediterranean Women For Serum Ferritin,Vitamin B12, And Folate Concentrations, Aysun Karabulut, Ömer Tolga Güler, Hati̇ce Tuba Karahan, Sevgi̇ Özkan, Hasan Koyuncu, İbrahi̇m Demi̇rci̇ler
Premarital Screening Of 466 Mediterranean Women For Serum Ferritin,Vitamin B12, And Folate Concentrations, Aysun Karabulut, Ömer Tolga Güler, Hati̇ce Tuba Karahan, Sevgi̇ Özkan, Hasan Koyuncu, İbrahi̇m Demi̇rci̇ler
Turkish Journal of Medical Sciences
Background/aim: Iron, folate, and vitamin B12 serum levels are closely related with dietary habits and have an essential role in the healthy development of a fetus. We aimed to investigate hemoglobin, ferritin, folate, and vitamin B12 levels in preconceptional women in an area where a plant-based diet referred to as Mediterranean cuisine is commonly used. Materials and methods: The study population included 466 women between the ages of 18 and 45 years admitted for thalassemia screening. Sociodemographic variables and history of menometrorrhagia, pica, and dietary habits were collected. Serum vitamin B12, folate, ferritin, and hemoglobin levels were measured. Ferritin of
Trace Elements Levels In The Serum, Urine, And Semen Of Patients With Infertility, Hasan Sali̇h Sağlam, Hüseyi̇n Altundağ, Yavuz Tarik Ati̇k, Mustafa Şahi̇n Dündar, Öztuğ Adsan
Trace Elements Levels In The Serum, Urine, And Semen Of Patients With Infertility, Hasan Sali̇h Sağlam, Hüseyi̇n Altundağ, Yavuz Tarik Ati̇k, Mustafa Şahi̇n Dündar, Öztuğ Adsan
Turkish Journal of Medical Sciences
Background/aim: Studies suggest that trace elements may have an adverse impact on male reproduction, even at low levels. We tried to investigate the relationships between these metals and semen quality in various body fluids among men with infertility. Materials and methods: A total of 255 samples of blood, semen, and urine were collected from 85 men suffering from infertility. Inductively coupled plasma-optical emission spectrometry was used for the determination of 22 trace elements. We compared the results of the semen parameters with the results of the element determinations. Results: Because of the high proportion of samples with values lower than …
Malondialdehyde And Nitric Oxide Levels And Catalase, Superoxide Dismutase, And Glutathione Peroxidase Levels In Maternal Blood During Different Trimesters Ofpregnancy And In The Cord Blood Of Newborns, Sevda Yüksel, Ayşe Arzu Yi̇ği̇t
Malondialdehyde And Nitric Oxide Levels And Catalase, Superoxide Dismutase, And Glutathione Peroxidase Levels In Maternal Blood During Different Trimesters Ofpregnancy And In The Cord Blood Of Newborns, Sevda Yüksel, Ayşe Arzu Yi̇ği̇t
Turkish Journal of Medical Sciences
Background/aim: To determine whether levels of malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) change during the 3 trimesters of pregnancy, and to compare the third trimester of pregnancy with newborn cord blood in respect to the levels of MDA, NO, and antioxidant enzymes. Materials and methods: Maternal blood samples were collected at 9?13, 22?26, and 36?40 weeks of gestation. Cord blood was collected at the time of delivery. Results: NO levels and GPx activity were higher in the second and third trimesters than in the first trimester. MDA level was lower in the …
Effect Of Pioglitazone, Quercetin, And Hydroxy Citric Acid On Vascular Endothelial Growth Factor Messenger Rna (Vegf Mrna) Expression In Experimentally Induced Nonalcoholic Steatohepatitis (Nash)*, Surapaneni Krishna Mohan, Vishnu Priya Veeraraghavan, Mallika Jainu
Effect Of Pioglitazone, Quercetin, And Hydroxy Citric Acid On Vascular Endothelial Growth Factor Messenger Rna (Vegf Mrna) Expression In Experimentally Induced Nonalcoholic Steatohepatitis (Nash)*, Surapaneni Krishna Mohan, Vishnu Priya Veeraraghavan, Mallika Jainu
Turkish Journal of Medical Sciences
Background/aim: Vascular endothelial growth factor (VEGF) is associated with various ischemic and inflammatory diseases, and plays an important role in the development of liver fibrosis and hepatocarcinogenesis in nonalcoholic steatohepatitis (NASH). In this study, the comparative effect of pioglitazone, quercetin, and hydroxy citric acid on VEGF mRNA in experimentally induced NASH was investigated. Materials and methods: The experimental protocol consisted of five groups: control, NASH, NASH + pioglitazone, NASH + quercetin, and NASH + hydroxy citric acid. The VEGF mRNA expression was evaluated by reverse transcription polymerase chain reaction (RT-PCR) analysis for all experimental groups, and the levels of VEGF …
Comparison Of The Contamination Rates Of Culture Media Used For Isolation And Identification Of Dermatophytes, Ramazan Gümral, Ayli̇n Döğen, Mehmet Maci̇t İlki̇t
Comparison Of The Contamination Rates Of Culture Media Used For Isolation And Identification Of Dermatophytes, Ramazan Gümral, Ayli̇n Döğen, Mehmet Maci̇t İlki̇t
Turkish Journal of Medical Sciences
Background/aim: Mycological media that promote spore production are essential for the diagnosis of dermatophytosis. However, these culture media frequently become contaminated by multiple fungal or bacterial species during culture. The aim of this study was to compare the contamination rates of 6 culture media used for the isolation and identification of dermatophytes, including Borelli's lactritmel agar (BLA), brain-heart infusion agar (BHIA), Lowenstein-Jensen agar (LJA), malt extract agar (MEA), potato dextrose agar (PDA), and Sabouraud glucose agar (SGA). Materials and methods: Agar plates were inoculated with 43 well-characterized dermatophyte strains, belonging to the genera Arthroderma, Epidermophyton, Microsporum, or Trichophyton. The agar …
Efficacy Of Diffusion-Weighted Magnetic Resonance Imaging In The Evaluation Of Extrahepatic Cholestasis-Related Hepatic Fibrosis, Süleyman Ayvaz, Sedat Alpaslan Tuncel, Güray Can, Beki̇r Çağli, Turan Karaca, Seli̇m Demi̇rtaş, Muhammed Elmaoğlu, Mehmet Ercüment Ünlü, Mehmet Pul
Efficacy Of Diffusion-Weighted Magnetic Resonance Imaging In The Evaluation Of Extrahepatic Cholestasis-Related Hepatic Fibrosis, Süleyman Ayvaz, Sedat Alpaslan Tuncel, Güray Can, Beki̇r Çağli, Turan Karaca, Seli̇m Demi̇rtaş, Muhammed Elmaoğlu, Mehmet Ercüment Ünlü, Mehmet Pul
Turkish Journal of Medical Sciences
Background/aim: To investigate the efficacy of diffusion-weighted magnetic resonance imaging (DWI) in the diagnosis and staging of fibrosis induced by experimental bile duct ligation (BDL). Materials and methods: Twenty-four rats were divided randomly into four groups: control, BDL - 3 days, BDL - 2 weeks, and BDL - 4 weeks. DWI was performed with b-values of 100 and 500 on the rats from control group at day zero, on the rats from the BDL - 3 days group at the end of day 3, on the rats from the BDL - 2 weeks group at the end of day 14, …
The Effects Of Aspirin, Flurbiprofen, And No-Donating Acetylsalicylic Acid(Ncx 4016) On Mice Models Of Endotoxic And Septic Shock, Nadi̇r Ulu, Alper Bektaş İski̇t, Cenk Sökmensüer, Mustafa Oğuz Güç
The Effects Of Aspirin, Flurbiprofen, And No-Donating Acetylsalicylic Acid(Ncx 4016) On Mice Models Of Endotoxic And Septic Shock, Nadi̇r Ulu, Alper Bektaş İski̇t, Cenk Sökmensüer, Mustafa Oğuz Güç
Turkish Journal of Medical Sciences
Background/aim: Nitric oxide-donating nonsteroidal antiinflammatory drugs (NO-NSAIDs) are a promising new class of antiinflammatory agents, which are obtained by adding NO-donating moieties to the existing conventional NSAID molecules. The aim of this study was to investigate the effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid (NCX 4016) on cecal ligation and puncture (CLP) and endotoxin-induced septic shock (LPS) models in mice. Materials and methods: Overall survival and spleen and liver weights were monitored in LPS and CLP models. Histopathological examinations of liver and spleen were performed at the end of the experimental protocols. Results: NCX 4016 was able to reverse …
The Relation Between Oxidative Stress Parameters, Ischemic Stroke,And Hemorrhagic Stroke, Ferhat İçme, Özcan Erel, Akkan Avci̇, Sali̇m Satar, Müge Gülen, Selen Acehan
The Relation Between Oxidative Stress Parameters, Ischemic Stroke,And Hemorrhagic Stroke, Ferhat İçme, Özcan Erel, Akkan Avci̇, Sali̇m Satar, Müge Gülen, Selen Acehan
Turkish Journal of Medical Sciences
Background/aim: The aims of this study were to investigate the significance of oxidative stress parameters in the pathogenesis of ischemic stroke and hemorrhagic stroke and to investigate their effects on stroke severity using the National Institutes of Health Stroke Scale (NIHSS). Materials and methods: A total of 92 patients, including 74 with ischemic stroke and 18 with hemorrhagic stroke, and 75 volunteers were enrolled in the study. Total oxidant status (TOS), total antioxidant status (TAS), paraoxonase, stimulating paraoxonase, arylesterase, and thiol levels were measured in both the patient and volunteer groups. NIHSS and oxidative stress index (OSI) scores were calculated. …
Risk Factors And Maximum Standardized Uptake Values Within Lymph Nodes Of Anthracosis Diagnosed By Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration, Ni̇lgün Yilmaz Demi̇rci̇, İbrahi̇m Onur Alici, Aydin Yilmaz, Funda Demi̇rağ, Ebru Tatci, Yurdanur Erdoğan
Risk Factors And Maximum Standardized Uptake Values Within Lymph Nodes Of Anthracosis Diagnosed By Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration, Ni̇lgün Yilmaz Demi̇rci̇, İbrahi̇m Onur Alici, Aydin Yilmaz, Funda Demi̇rağ, Ebru Tatci, Yurdanur Erdoğan
Turkish Journal of Medical Sciences
Background/aim: Enlarged mediastinal lymph nodes can result from serious etiologies including granulomatous disease, neoplasia, etc., and a rare condition called anthracosis . The aim of this study was to determine the incidence of risk factors and the uptake values within the anthracotic lymph nodes. Materials and methods: 106 patients who underwent endobronchial ultrasound transbronchial needle aspiration and were diagnosed as having anthracosis were analyzed retrospectively. Patients with positive confirmation by surgical biopsies or a 1-year follow-up period were enrolled. Results: 201 lymph nodes were sampled from 106 patients. Subcarinal and interlobar lymph nodes were the most commonly affected stations (36.8% …
Role Of Autophagy In The Pathogenesis Of Alzheimer Disease, Muhammet Cemal Kizilarslanoğlu, Zekeri̇ya Ülger
Role Of Autophagy In The Pathogenesis Of Alzheimer Disease, Muhammet Cemal Kizilarslanoğlu, Zekeri̇ya Ülger
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is the most common progressive neurodegenerative disorder causing increased morbidity and mortality. It is characterized by accumulation of amyloid-β in neurons. As there is no known definitive treatment of this disorder, studies trying to determine its exact pathogenetic pathways and target therapies for these specific pathways are being rapidly conducted. Autophagy is one of the areas of interest in studies on the pathogenesis of AD. It is a process of self-digestion that is thought to be a response to stressors and allows cells to adapt to environmental changes. There is accumulating evidence showing an association between autophagy …
Nutritional Issues In Dementia Patients, Mustafa Kemal Kiliç, Fati̇h Sümer, Zekeri̇ya Ülger
Nutritional Issues In Dementia Patients, Mustafa Kemal Kiliç, Fati̇h Sümer, Zekeri̇ya Ülger
Turkish Journal of Medical Sciences
Dementia is an inevitable disease of aging, leading not only to diminished cognitive ability but also behavioral changes, malnutrition, pressure sores, and infections. Acknowledging common problems and their solutions is essential for any health service worker who deals with demented geriatric patients.