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An Anatomical Study Of The Supratrochlear Foramen Of The Jining Population, Jing Li, Qinghua Mao, Wenyuan Li, Xiaoyan Li
An Anatomical Study Of The Supratrochlear Foramen Of The Jining Population, Jing Li, Qinghua Mao, Wenyuan Li, Xiaoyan Li
Turkish Journal of Medical Sciences
Background/aim: The supratrochlear foramen (STF) is an important variation in the lower end of the humerus where the septum separating the coronoid and olecranon fossa is perforated. There are no studies in the literature on the STF of the Jining population. This study will make a contribution to anatomy and anthropology by adding new data. Materials and methods: STF was studied in detail in 262 adult dried humeri of unknown sex and age. The topographical anatomy of the STF was studied, morphometric measurements were taken, and the specimens were photographed with a digital camera. Results: The prevalence of the STF …
Paclitaxel-Loaded Niosomes For Intravenous Administration: Pharmacokineticsand Tissue Distribution In Rats, Zerri̇n Sezgi̇n Bayindir, Arzu Beşi̇kci̇, Ni̇lüfer Yüksel
Paclitaxel-Loaded Niosomes For Intravenous Administration: Pharmacokineticsand Tissue Distribution In Rats, Zerri̇n Sezgi̇n Bayindir, Arzu Beşi̇kci̇, Ni̇lüfer Yüksel
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, after intravenous injection to rats. Materials and methods: Paclitaxel-loaded Span 40 niosomes were prepared using the thin-film method. An HPLC method was developed and validated for paclitaxel determination in rat plasma and tissues. Results: The area under the curve value of the niosome-recipient group (3.22 ± 0.255 μg h/mL) was significantly higher compared to that of the Taxol group (0.725 ± 0.163 μg h/mL). The mean residence time and the elimination …
Comparison Of Thiopental And Ketamine+Xylazine Anesthesia Inischemia/Reperfusion-Induced Arrhythmias In Rats, Ersöz Gonca
Comparison Of Thiopental And Ketamine+Xylazine Anesthesia Inischemia/Reperfusion-Induced Arrhythmias In Rats, Ersöz Gonca
Turkish Journal of Medical Sciences
Background/aim: To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias. Materials and methods: Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reperfusion. Measurements were taken of the incidence and duration of ventricular arrhythmias, the mean arterial blood pressure and heart rate, and the pressure rate-product (as an index of myocardial oxygen consumption). Results: The arrhythmia score and the incidence of ventricular fibrillation and tachycardia were significantly decreased in the …
Effects Of Prenatally Exposed Diclofenac Sodium On Rat Heart Tissue:A Stereological And Histological Study, Fi̇kret Gevrek, Mi̇kai̇l Kara, Murat Çeti̇n Rağbetli̇, Hüseyi̇n Aslan
Effects Of Prenatally Exposed Diclofenac Sodium On Rat Heart Tissue:A Stereological And Histological Study, Fi̇kret Gevrek, Mi̇kai̇l Kara, Murat Çeti̇n Rağbetli̇, Hüseyi̇n Aslan
Turkish Journal of Medical Sciences
Background/aim: Diclofenac sodium (DS) can cross the placental barrier and affect the fetus, and its consumption during pregnancy may cause developmental malformation of embryos. This study investigates the effect of prenatally applied DS on the quantitative morphology of the adult rat heart. Materials and methods: Pregnant rats were divided into three groups (control, sham, and test). The rats in the test group were injected with DS; the control group received physiological saline (1 mL; 1 mg/kg, i.m.) from the 5th to the 20th day of pregnancy; and the rats in the sham group were not injected at all. At the …
Does Glp-2 Have A Protective Effect On Cerebral Ischemia/Reperfusion Model?, Naci̇ Topaloğlu, Gülsün Memi̇, Tuncay Kaner, Mustafa Deni̇z, Önder Şahi̇n, Mustafa Güven, Murat Çoşar
Does Glp-2 Have A Protective Effect On Cerebral Ischemia/Reperfusion Model?, Naci̇ Topaloğlu, Gülsün Memi̇, Tuncay Kaner, Mustafa Deni̇z, Önder Şahi̇n, Mustafa Güven, Murat Çoşar
Turkish Journal of Medical Sciences
Background/aim: To investigate the neuroprotective effects of glucagon-like peptide 2 (Glp-2), which increases cerebral blood flow, on the hippocampal complex after cerebral ischemia/reperfusion (I/R) injury in rats. Materials and methods: Animals were randomized into 4 groups: sham, I/R + 0.9% NaCl, I/R + pre-Glp-2, and I/R + post-Glp-2. Cerebral ischemia was performed via the occlusion of the bilateral internal carotid artery for 40 min and continued with a reperfusion process. At the end of 6 h of reperfusion, animals were decapitated in all groups and brain tissues were removed. Malondialdehyde (MDA) and natural intracellular antioxidant glutathione (GSH) levels and myeloperoxidase …
Prevention Of Methotrexate-Induced Nephrotoxicity By Concomitantadministration Of Garlic Aqueous Extract In Rat, Walaa Ahmed, Amr Zaki, Taghred Nabil
Prevention Of Methotrexate-Induced Nephrotoxicity By Concomitantadministration Of Garlic Aqueous Extract In Rat, Walaa Ahmed, Amr Zaki, Taghred Nabil
Turkish Journal of Medical Sciences
Background/aim: Methotrexate (MTX) has been widely used for treatment of cancer and rheumatoid arthritis, but its use has been limited by its nephrotoxicity. This study was carried out to determine whether garlic exerts a protective effect against MTX-induced nephrotoxicity. Materials and methods: Nephrotoxicity was induced in rats after a single i.p. injection of MTX (20 mg/kg). Garlic extract (1 mL/100 g b.w.) was given orally for 7 days before and after MTX administration. Serum samples were collected to evaluate urea, creatinine, sodium, phosphorous, potassium, and calcium. Reduced glutathione, catalase, adenosine deaminase, nitric oxide, and malondialdehyde were measured in renal tissue. …
The Expression Profile Of Aquaporin 1 In Rat Myocardium After Severe Burns, Wanli Li, Longying Zha, Zhiqing Li, Yuesheng Huang, Yiping Zhou
The Expression Profile Of Aquaporin 1 In Rat Myocardium After Severe Burns, Wanli Li, Longying Zha, Zhiqing Li, Yuesheng Huang, Yiping Zhou
Turkish Journal of Medical Sciences
Background/aim: To investigate the myocardial expression profile of aquaporin 1 (AQP1) in rats after severe burns. Materials and methods: Ninety healthy male adult Wistar rats were randomly assigned to the following treatments: sham operation (control group, n = 6), immediate fluid resuscitation treatment post scalding (IF group, n = 42), and delayed fluid resuscitation treatment after scalding (DF group, n = 42). At 3, 6, 12, 24, 48, 72, and 120 h after scalding, myocardial water contents were assayed and AQP1 expressions were detected by real-time polymerase chain reaction and western blot. The AQP levels in the myocardium at 12 …
Prospective Investigation Of The Hypothalamo?Pituitary?Adrenalaxis In Patients With Tularemia, Hayati̇ Demi̇raslan, Yasi̇n Şi̇mşek, Fati̇h Tanriverdi̇, Mehmet Doğanay, Hasan Fahretti̇n Keleştemur
Prospective Investigation Of The Hypothalamo?Pituitary?Adrenalaxis In Patients With Tularemia, Hayati̇ Demi̇raslan, Yasi̇n Şi̇mşek, Fati̇h Tanriverdi̇, Mehmet Doğanay, Hasan Fahretti̇n Keleştemur
Turkish Journal of Medical Sciences
Background/aim: To investigate prospectively the hypothalamo-pituitary-adrenal (HPA) axis by adrenocorticotropic hormone (ACTH) stimulation test. Materials and methods: Tularemia was diagnosed according to guidelines. An ACTH stimulation test (1 µg) and a dexamethasone suppression test (DST; 1 mg) were performed in patients in the acute phase of tularemia before antibiotic treatment and in the chronic phase. Results: Nineteen patients (mean age: 41.0 ± 13.2 years; 57.9% female) with tularemia were enrolled in the study in 2011 and 2012. Cortisol response to ACTH stimulation test was sufficient in all patients during the acute phase. After the DST, the cortisol was not suppressed …
The Effect Of Vitamin E And L-Carnitine Against Methotrexate-Induced Injury In Rat Testis, Mehmet Yüncü, Nezahat Bükücü, Nuray Bayat, Leman Sencar, Mehmet Tarakçioğlu
The Effect Of Vitamin E And L-Carnitine Against Methotrexate-Induced Injury In Rat Testis, Mehmet Yüncü, Nezahat Bükücü, Nuray Bayat, Leman Sencar, Mehmet Tarakçioğlu
Turkish Journal of Medical Sciences
Background/aim: Methotrexate (MTX), used commonly as an antimetabolite drug in cancer therapy, leads to acute toxic side effects in tissues or organs containing rapidly dividing cells, such as bone marrow, gastrointestinal mucosa, and seminiferous tubules. In this study, we investigated the protective effects of vitamin E and L-carnitine against MTX-induced injury in rat testis. Materials and methods: Rats were divided into 4 groups, including the control group. The study took 17 days and the animals received daily doses of 0.5 mL/kg saline, 250 mg/kg vitamin E, or 500 mg/kg L-carnitine intraperitoneally. The experimental groups received 20 mg/kg methotrexate intraperitoneally on …
Chronology Of Estrogen Receptor Expression In Testes Of Mouse Embryos, Insaf Jasim Mahmoud, Mohammad Oda Selman, Wameedh Raad Abdulmalik Shebeb
Chronology Of Estrogen Receptor Expression In Testes Of Mouse Embryos, Insaf Jasim Mahmoud, Mohammad Oda Selman, Wameedh Raad Abdulmalik Shebeb
Turkish Journal of Medical Sciences
Background/aim: To localize and determine the time of expression of estrogen receptors (ERs) in testes of mouse embryos by histology and immunohistochemistry. Materials and methods: Fifty-four mature Swiss-Webster mice (Mus musculus) were used. Group 1 consisted of 34 mature pregnant females, 3 of which were sacrificed every day from 10.5 to 20.5 days postcoitus (dpc). One testis was removed from their embryos and processed for histology and immunohistochemistry. Group 2 consisted of 20 postnatal mice: 5 postpartum (P0) males, 5 males 4 weeks old, 5 males 8 weeks old, and 5 females 4 weeks old. Results: The first nuclear detection …
Effects Of Grape Seed Extract On Oxidative Stress And Antioxidant Defensemarkers In Streptozotocin-Induced Diabetic Rats, Muaz Belvi̇ranli, Hakki Gökbel, Ni̇lsel Okudan, Sadik Büyükbaş
Effects Of Grape Seed Extract On Oxidative Stress And Antioxidant Defensemarkers In Streptozotocin-Induced Diabetic Rats, Muaz Belvi̇ranli, Hakki Gökbel, Ni̇lsel Okudan, Sadik Büyükbaş
Turkish Journal of Medical Sciences
Background/aim: To evaluate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant markers in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Thirty-six male rats were divided into the following four groups: control, GSE-supplemented control, diabetic, and GSE-supplemented diabetic. Beginning on day 7 after STZ injection, the rats were administered GSE (100 mg kg-1 day-1) in drinking water for 6 weeks. At the end of week 6, rats were sacrificed by cardiac puncture. Plasma nitric oxide (NO) levels and xanthine oxidase (XO), adenosine deaminase (ADA), and glutathione peroxidase (GPx) activities were analyzed. Results: Both XO and ADA …
A Study Of The Effect Of Bacillus Thuringiensis Serotype H14 (Subspecies Israelensis)Delta Endotoxin On Musca Larva, Mohammad Reza Mehrabi, Laya Zoghimofrad, Mahboubeh Mazinani, Azim Akbarzadeh, Amirabbas Rahimi
A Study Of The Effect Of Bacillus Thuringiensis Serotype H14 (Subspecies Israelensis)Delta Endotoxin On Musca Larva, Mohammad Reza Mehrabi, Laya Zoghimofrad, Mahboubeh Mazinani, Azim Akbarzadeh, Amirabbas Rahimi
Turkish Journal of Medical Sciences
Background/aim: House flies (Musca domestica) are of major public health concern in areas with poor sanitation and hygiene conditions. Biological control through the use of parasitoids and pathogens is one of the alternatives to the use of chemical pesticides for control of insects of public health importance. Materials and methods: The effects of the delta endotoxin of Bacillus thuringiensis on house fly larval mortality were studied. Gel filtration and SDS-PAGE methods were used for separation and purification of proteins. Delta endotoxin was incubated with larvae in concentrations of 0.43 mg/mL and 0.27 mg/mL in bioassay tests. Results: The results of …
The Effect Of Swimming And Type Of Stroke On Bone Metabolism In Competitiveadolescent Swimmers: A Pilot Study, Si̇nem Akgül, Nuray Kanbur, Şükrü Alpan Ci̇nemre, Erdem Karabulut, Orhan Derman
The Effect Of Swimming And Type Of Stroke On Bone Metabolism In Competitiveadolescent Swimmers: A Pilot Study, Si̇nem Akgül, Nuray Kanbur, Şükrü Alpan Ci̇nemre, Erdem Karabulut, Orhan Derman
Turkish Journal of Medical Sciences
Background/aim: Physical activity plays a key role in increasing and preserving bone mineral density (BMD). Effects on bone development associated with various nonweight-bearing sporting activities, such as swimming, are controversial. Different strokes used in swimming may also present as another factor. The aim of this study was to evaluate the effect of swimming and type of stroke on BMD in competitive adolescent athletes. Materials and methods: Seventy-nine swimmers between the ages of 10 and 21 years participated in this study. BMD was measured with dual-energy X-ray absorptiometry at the lumbar vertebrae and left proximal femur. Daily calorie intake and calcium …
Effects Of Melatonin And Theanine Administration On Pentylenetetrazole-Inducedseizures And Brain Tissue Oxidative Damage In Ovariectomized Rats, Shadi Choopankareh, Farzaneh Vafaee, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Reza Salarinia, Leila Zarepoor, Mahmoud Hosseini
Effects Of Melatonin And Theanine Administration On Pentylenetetrazole-Inducedseizures And Brain Tissue Oxidative Damage In Ovariectomized Rats, Shadi Choopankareh, Farzaneh Vafaee, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Reza Salarinia, Leila Zarepoor, Mahmoud Hosseini
Turkish Journal of Medical Sciences
Background/aim: The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats. Materials and methods: The rats were divided into the following groups: 1) sham, 2) ovariectomized (OVX), 3) sham-PTZ, 4) OVX-PTZ, 5) sham-Mel/Thea-PTZ, and 6) OVX-Mel/Thea-PTZ. Groups 1-4 received saline, while groups 5 and 6 received a combination of Mel/Thea for 6 weeks. All animals except for those in groups 1 and 2 received a single injection of PTZ. Results: The OVX-PTZ group had higher generalized tonic-clonic seizure (GTCS) latency compared to the sham-PTZ …
Hepatoprotective And Antioxidant Effects Of Lycopene In Acute Cholestasis, Mehmet Tokaç, Sevtap Aydin, Gökçe Taner, Alper Bi̇lal Özkardeş, Mi̇ne Yavuz Taşlipinar, Mehmet Doğan, Hali̇t Zi̇ya Dündar, Mehmet Kiliç, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran
Hepatoprotective And Antioxidant Effects Of Lycopene In Acute Cholestasis, Mehmet Tokaç, Sevtap Aydin, Gökçe Taner, Alper Bi̇lal Özkardeş, Mi̇ne Yavuz Taşlipinar, Mehmet Doğan, Hali̇t Zi̇ya Dündar, Mehmet Kiliç, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran
Turkish Journal of Medical Sciences
Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats. Materials and methods: The animals were randomized into 3 groups. The sham group was subjected to a sham operation, the BDL group was subjected to bile duct ligation (BDL), and the BDL+L group was subjected to BDL …
Epidemiological And Clinical Characteristics And Management Of Oropharyngeal Tularemia Outbreak, Mustafa Önder Uzun, Kerametti̇n Yanik, Müge Erdem, Uğur Kostakoğlu, Gürdal Yilmaz, Yeli̇z Tanriverdi̇ Çayci
Epidemiological And Clinical Characteristics And Management Of Oropharyngeal Tularemia Outbreak, Mustafa Önder Uzun, Kerametti̇n Yanik, Müge Erdem, Uğur Kostakoğlu, Gürdal Yilmaz, Yeli̇z Tanriverdi̇ Çayci
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to determine the epidemiological and clinical characteristics of patients diagnosed with tularemia and the effectiveness of the administered treatments. Materials and methods: Patients treated in our hospital between January 2009 and March 2011 and diagnosed with tularemia were evaluated retrospectively. Patients' epidemiological and clinical characteristics, administered treatments, and posttreatment findings were recorded on patient monitoring forms. Results: At anamnesis, 29% of patients used water from wells and 71% used water from the network supply; moreover, 48.4% had a history of contact with animals and 87.1% a history of lethargy. At physical examination, 96.8% …
Herbal Self-Medication Use In Patients With Diabetes Mellitus Type 2, Ivana Damnjanovic, Dusanka Kitic, Nikola Stefanovic, Snezana Zlatkovic-Guberinic, Aleksandra Catic-Djordjevic, Radmila Velickovic-Radovanovic
Herbal Self-Medication Use In Patients With Diabetes Mellitus Type 2, Ivana Damnjanovic, Dusanka Kitic, Nikola Stefanovic, Snezana Zlatkovic-Guberinic, Aleksandra Catic-Djordjevic, Radmila Velickovic-Radovanovic
Turkish Journal of Medical Sciences
Background/aim: A considerable number of patients suffering from diabetes mellitus (DM) turn to self-medication using medicinal plants, preparations, and medicine. The aim of this study was to investigate self-medication using medicinal plants and the potential influence of health care professionals' advice or media information regarding the use of herbal dietary supplements with hypoglycemic effect in a population of patients with type 2 DM. Materials and methods: This research, in the form of an analytic cross-sectional study, was conducted in 6 pharmacies in the territory of Nis, Serbia, during October 2013. The criterion set for the study was to include patients …
A Turkish 3-Center Study Evaluation Of Serum Folic Acid And Vitamin B12 Levels In Alzheimer Disease, Nuri̇ye Nuray Ulusu, Gökhan Yilmaz, Zübeyde Erbayraktar, Ahmet Turan Evli̇ce, Sevgi̇ Aras, Görsev Yener, Aslihan Avci
A Turkish 3-Center Study Evaluation Of Serum Folic Acid And Vitamin B12 Levels In Alzheimer Disease, Nuri̇ye Nuray Ulusu, Gökhan Yilmaz, Zübeyde Erbayraktar, Ahmet Turan Evli̇ce, Sevgi̇ Aras, Görsev Yener, Aslihan Avci
Turkish Journal of Medical Sciences
Background/aim: Alzheimer disease, a common proteopathy of advanced age, is characterized by cortical atrophy, neuron degeneration, neuronal loss, and accumulation of extracellular amyloid β plaques. We aimed to investigate serum vitamin B12 and folic acid levels in Alzheimer disease and other dementia patients, as a potential screening test to detect presymptomatic Alzheimer disease in Turkish patients. Materials and methods: We evaluated folic acid and vitamin B12 levels in Alzheimer disease patients as well as in other dementia and geriatric patients from Ankara, Dokuz Eylül, and Çukurova university hospitals; 290 female and male geriatric subjects were enrolled. Vitamin B12 and folic …
Beneficial Effects Of Melatonin And Bq-123 On The Rat Testis Damage Caused By Cigarette Smoke, Hüseyi̇n Aslan, Hakan Kesi̇ci̇, Zafer İsmai̇l Karaca, Bi̇rsen Özyurt, Ufuk Taş, Fati̇h Eki̇ci̇, Hasan Erdoğan, Fi̇kret Gevrek, Sevi̇l Çayli
Beneficial Effects Of Melatonin And Bq-123 On The Rat Testis Damage Caused By Cigarette Smoke, Hüseyi̇n Aslan, Hakan Kesi̇ci̇, Zafer İsmai̇l Karaca, Bi̇rsen Özyurt, Ufuk Taş, Fati̇h Eki̇ci̇, Hasan Erdoğan, Fi̇kret Gevrek, Sevi̇l Çayli
Turkish Journal of Medical Sciences
Several studies have demonstrated that cigarette smoke has detrimental effects on testicular function. However, it is unknown whether melatonin or BQ-123 has beneficial effects on the rat testis damage caused by cigarette smoke. The aim of the present study was to investigate the beneficial effects of melatonin or BQ-123 on the testicular damage caused by cigarette smoke. Materials and methods: Twenty Wistar rats were randomly divided into 4 equal groups: control group (n = 5), cigarette smoke group (n = 5), melatonin group (n = 5), and BQ-123 group (n = 5). At the end of 4 weeks, all the …
Parp Inhibition Prevents Acetaminophen-Induced Liver Injury And Increases Survival Rate In Rats, Melahat Dönmez, Bülent Uysal, Yavuz Poyrazoğlu, Yeşi̇m Er Öztaş, Türker Türker, Ümi̇t Kaldirim, Ahmet Korkmaz
Parp Inhibition Prevents Acetaminophen-Induced Liver Injury And Increases Survival Rate In Rats, Melahat Dönmez, Bülent Uysal, Yavuz Poyrazoğlu, Yeşi̇m Er Öztaş, Türker Türker, Ümi̇t Kaldirim, Ahmet Korkmaz
Turkish Journal of Medical Sciences
Acetaminophen (APAP) overdose results in severe liver damage that may develop into acute liver failure. Recent studies have demonstrated that inhibition of poly(ADP-ribose) polymerase (PARP) decreases tissue necrosis and inflammation. We evaluated the efficacy of 3-aminobenzamide (3-AB), a PARP inhibitor, in a rodent model of APAP-induced hepatotoxicity. Materials and methods: Twenty-four Sprague-Dawley rats were divided equally into 3 experimental groups: sham group, APAP group, and APAP + 3-AB group. In the experimental treatment groups APAP was administered orally at 1 g/kg and, in the APAP + 3-AB group, 3-AB was administered intraperitoneally at a dose of 20 mg/kg exactly 1 …
Protective Effects Of Royal Jelly Against Testicular Damage In Streptozotocin-Induced Diabetic Rats, Turan Karaca, Seli̇m Demi̇rtaş, İhsan Karaboğa, Süleyman Ayvaz
Protective Effects Of Royal Jelly Against Testicular Damage In Streptozotocin-Induced Diabetic Rats, Turan Karaca, Seli̇m Demi̇rtaş, İhsan Karaboğa, Süleyman Ayvaz
Turkish Journal of Medical Sciences
To examine the effects of royal jelly (RJ) on testicular damage in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Eighteen adult Wistar albino rats were used, 6 in each of the 3 treatment groups: Group A: control, Group B: STZ-induced diabetes (untreated), Group C: STZ-induced diabetes plus RJ (400 mg/kg daily for 4 weeks). Diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg). Four weeks after the onset of diabetes, testicular apoptotic cell death was examined using immunohistochemical staining for caspase-3 and Ki67 staining for localization of proliferative cells. Results: Compared with the control, the body and …
An In Vitro And In Vivo Investigation Of The Cytotoxic Effects Of Caffeic Acid (3,4-Dihydroxycinnamic Acid) Phenethyl Ester And Bortezomib In Multiple Myeloma Cells, Ertan Altayli, Özgür Koru, Önder Öngürü, Tayfun İde, Cengi̇zhan Açikel, Meral Sarper, Mualla Pinar Elçi̇, Rahşan Ilikçi Sağkan, Erhan Astarci, Duran Tok, Sali̇m Özenç, Ali̇ Uğur Ural, Feri̇t Avcu
An In Vitro And In Vivo Investigation Of The Cytotoxic Effects Of Caffeic Acid (3,4-Dihydroxycinnamic Acid) Phenethyl Ester And Bortezomib In Multiple Myeloma Cells, Ertan Altayli, Özgür Koru, Önder Öngürü, Tayfun İde, Cengi̇zhan Açikel, Meral Sarper, Mualla Pinar Elçi̇, Rahşan Ilikçi Sağkan, Erhan Astarci, Duran Tok, Sali̇m Özenç, Ali̇ Uğur Ural, Feri̇t Avcu
Turkish Journal of Medical Sciences
In this study, the in vitro and in vivo effectiveness of caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) in combination with bortezomib, a proteasome inhibitor, was explored in multiple myeloma (MM) cells. Materials and methods: The cytotoxic effects of CAPE and bortezomib were determined by XTT cell proliferation assay. Apoptosis levels were analyzed with annexin V-fluorescein isothiocyanate, nuclear factor kappa beta (NF-\kappaB) was analyzed with electrophoretic mobility-shift assay, and interleukin (IL)-6 levels were analyzed with enzyme-linked immunosorbent assay to evaluate CAPE's mechanism of action. To investigate the in vivo effectiveness of CAPE and bortezomib, an experimental plasmacytoma model was induced …
Comparative Study Of Virulence Factors Among Esβl-Producing And Nonproducing Pseudomonas Aeruginosa Clinical Isolates, Maha Abd El Fattah Khalil, Fatma Ibrahim Sonbol, Abdelfattah Badr, Samh Samir Ali
Comparative Study Of Virulence Factors Among Esβl-Producing And Nonproducing Pseudomonas Aeruginosa Clinical Isolates, Maha Abd El Fattah Khalil, Fatma Ibrahim Sonbol, Abdelfattah Badr, Samh Samir Ali
Turkish Journal of Medical Sciences
\beta-Lactamase production is considered one of the most important resistance mechanisms among virulent Pseudomonas aeruginosa isolates. The aim of this study was to compare the production and antimicrobial resistance patterns of some virulence factors in extended spectrum \beta-lactamase (ES\betaL)-producing and nonproducing P. aeruginosa clinical isolates. Materials and methods: Out of 183 different clinical specimens, 104 Pseudomonas aeruginosa isolates were recovered. The isolates were screened for ESbL production using the double disk diffusion test and phenotypic confirmatory disk diffusion test. All isolates were tested for susceptibility to 25 antimicrobials, as well as for expression of various virulence factors including pigment, hemolysin, …
Investigation Of West Nile Virus Among Healthy Blood Donors In The Western Part Of Turkey, Servet Uluer Bi̇çeroğlu, Ersi̇n Karatayli, Arzu Bayram, Ajda Turhan, Aysu Deği̇rmenci̇, Yeşi̇m Aydinok, Abdurrahman Mi̇that Bozdayi, Şazi̇ye Rüçhan Sertöz
Investigation Of West Nile Virus Among Healthy Blood Donors In The Western Part Of Turkey, Servet Uluer Bi̇çeroğlu, Ersi̇n Karatayli, Arzu Bayram, Ajda Turhan, Aysu Deği̇rmenci̇, Yeşi̇m Aydinok, Abdurrahman Mi̇that Bozdayi, Şazi̇ye Rüçhan Sertöz
Turkish Journal of Medical Sciences
The West Nile virus (WNV) is a mosquito-borne flavivirus causing different forms of infection among humans, varying from asymptomatic illness to fetal central nervous system infection. Turkey lies within an endemic region for WNV. Transfusion of infected blood products is another well-documented major route of transmission. The aim of our study was to investigate the presence of WNV viremia among a healthy donor population from the western part of the country. Materials and methods: A total of 438 healthy volunteer blood donors were included in the study. The presence of WNV RNA was investigated by quantitative real-time reverse-transcriptase polymerase chain …
Assessment Of Nasal Mucociliary Clearance In Anesthetists, Eyüp Horasanli, Aydin Acar, Bünyami̇n Muslu, Meli̇h Çayönü, Murat Çi̇mencan, Serkan Kayabaşi
Assessment Of Nasal Mucociliary Clearance In Anesthetists, Eyüp Horasanli, Aydin Acar, Bünyami̇n Muslu, Meli̇h Çayönü, Murat Çi̇mencan, Serkan Kayabaşi
Turkish Journal of Medical Sciences
To assess mucociliary clearance in anesthetists who were exposed to waste anesthetic gases occupationally. Materials and methods: The first group consisted of 30 anesthetists who had been working at least 2 years. The control group of 30 subjects was selected from hospital staff with no history of occupational exposure to waste anesthetic gases. Mucociliary clearance time was assessed by measuring the saccharine nasal transit time (SNTT). Results: Thirty-six women and 24 men aged between 25 and 60 years were enrolled in the study. There were no differences between the anesthetist and control groups in terms of age, sex, height, or …
The Protective Effect Of Syringic Acid On Ischemia Injury In Rat Brain, Mustafa Güven, Adem Bozkurt Aras, Naci̇ Topaloğlu, Adi̇le Özkan, Hali̇l Murat Şen, Yildiray Kalkan, Ali̇ Okuyucu, Ayla Akbal, Ferhat Gökmen, Murat Çoşar
The Protective Effect Of Syringic Acid On Ischemia Injury In Rat Brain, Mustafa Güven, Adem Bozkurt Aras, Naci̇ Topaloğlu, Adi̇le Özkan, Hali̇l Murat Şen, Yildiray Kalkan, Ali̇ Okuyucu, Ayla Akbal, Ferhat Gökmen, Murat Çoşar
Turkish Journal of Medical Sciences
Brain ischemia and treatment are important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most significant causes of damage. Currently there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our aim is to research the preventive effect of the active ingredient in syringic acid, previously unstudied, on oxidative damage in cerebral ischemia. Materials and methods: The rats were randomly divided into 4 groups: control group (no medication or surgical procedure), sham group (artery occlusion), artery occlusion + syringic acid group sacrificed at 6 h, and artery occlusion + syringic …
A Comparative Analysis Of Membrane Intactness And Genome Integrity In Pea,Barley, And Wheat In Response To Uvc Irradiation, Mariyana Georgieva, Ivelina Nikolova, Georgi Bonchev, Zornitsa Katerova, Dessislava Todorova
A Comparative Analysis Of Membrane Intactness And Genome Integrity In Pea,Barley, And Wheat In Response To Uvc Irradiation, Mariyana Georgieva, Ivelina Nikolova, Georgi Bonchev, Zornitsa Katerova, Dessislava Todorova
Turkish Journal of Botany
The maintenance of plant genome integrity plays a critical function in the processes of DNA replication, transcription, and repair. Short-wave UV radiation (UVC) is among the most harmful agents known to affect genome stability and to induce DNA damage, including double-strand breaks (DSBs). Most previous studies in plants addressed the effects of UVC radiation at the physiological level; however, little research effort has been put into genome sensitivity across different plant species. Here, we made use of the trypan blue exclusion test and neutral comet assay to assess nuclear membrane and genome integrity in response to UVC radiation in monocot …
Cdna Cloning, Molecular Characterization, And Expression Analyses Of Two Novel Porcine Arrdc Genes-Arrdc1 And Arrdc, Hailong Huo, Pei Wang, Shuyan Wang, Yongwang Miao, Hongjiang Wei, Yongyun Zhang, Qiaoling Zhang, Fuquan Li, Lixian Liu, Rui Wang, Weizhen Li, Yue Zhao, Jinlong Huo, Heng Xiao
Cdna Cloning, Molecular Characterization, And Expression Analyses Of Two Novel Porcine Arrdc Genes-Arrdc1 And Arrdc, Hailong Huo, Pei Wang, Shuyan Wang, Yongwang Miao, Hongjiang Wei, Yongyun Zhang, Qiaoling Zhang, Fuquan Li, Lixian Liu, Rui Wang, Weizhen Li, Yue Zhao, Jinlong Huo, Heng Xiao
Turkish Journal of Biology
Arrestin-domain-containing proteins belong to the arrestin family, embers of which are important for regulating signal transduction within cells. In this study, two ARRDC genes (ARRDC1 and ARRDC5) of Diannan small-ear pigs were amplified by reverse transcription polymerase chain reaction and cloned for the first time (accession nos.: KF589202 and KF589203). The full-length coding sequence of ARRDC1 was 1284 nucleotides in length (molecular weight, 45.6 kDa; pI, 7.61) and encoded 427 amino acids. The ARRDC5CDS was 1014 nucleotides in length (molecular weight, 37.5 kDa; pI, 7.08) and encoded 337 amino acids. Sequence homology analysis revealed that the amino acid sequences of …
Ghrelin Effects On Midgut Tissue Antioxidative Defense And Glutathione S-Transferase Activity In Lymantria Dispar (Lepidoptera), Vesna Peric Mataruga, Milena Vlahovic, Marija Mrdakovic, Dragana Matic, Anja Gavrilovic, Aleksandra Mrkonja, Larisa Ilijin
Ghrelin Effects On Midgut Tissue Antioxidative Defense And Glutathione S-Transferase Activity In Lymantria Dispar (Lepidoptera), Vesna Peric Mataruga, Milena Vlahovic, Marija Mrdakovic, Dragana Matic, Anja Gavrilovic, Aleksandra Mrkonja, Larisa Ilijin
Turkish Journal of Biology
The aim of the study was to examine changes in Cu?Zn superoxide dismutase (SOD), catalase (CAT), their gel electrophoresis profiles, glutathione reductase (GR) activity, amount of glutathione (GSH), and the activity of glutathione S-transferase (GST) - phase II biotransformation enzyme in the midgut tissue of gypsy moth (Lymantria dispar L. (Lepidoptera: Lymantriidae)) larvae after ghrelin treatment. Four subpicomolar injections of ghrelin (0.3 pmol) or physiological saline (control) were applied every 24 h. The SOD, CAT, GR, GST activity, and amount of GSH were higher in the ghrelin-treated group than in the control. Electrophoresis gel bands of SOD and CAT had …