Digital Commons Network^™

The 3-Hydroxy-3-Methylglutaryl Coenzyme-A (Hmg-Coa) Reductases, Jon A. Friesen, Victor W. Rodwell

Department of Biochemistry Faculty Publications

The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the conversion of HMG-CoA to mevalonate, a four-electron oxidoreduction that is the rate-limiting step in the synthesis of cholesterol and other isoprenoids. The enzyme is found in eukaryotes and prokaryotes; and phylogenetic analysis has revealed two classes of HMG-CoA reductase, the Class I enzymes of eukaryotes and some archaea and the Class II enzymes of eubacteria and certain other archaea. Three-dimensional structures of the catalytic domain of HMG-CoA reductases from humans and from the bacterium Pseudomonas mevalonii, in conjunction with site-directed mutagenesis studies, have revealed details of the mechanism of catalysis. …

The Use Of Vegetation In The Stabilization, Reclamation, And Remediation Of Impacted Indot Soils, Mark S. Mcclain, M. K. Banks, A. Paul Schwab

JTRP Technical Reports

The major goal of this project was to write the manual PhytoRemediate®: Phytoremediation Decision Guide for Transportation Engineers and the attached compact disk PhytoRemediate®: Training Module for Transportation Engineers to assist transportation engineers and other professionals in the applicability of phytoremediation as an effective method of remediation engineering design. This guide is not a design manual, but identifies the decision-making processes necessary for successful remediation of contaminated sites using phytoremediation.

A phytoremediation users' manual PhytoRemediate®: Phytoremediation Decision Guide for Transportation Engineers was developed to assist INDOT personnel in the areas of site assessment, plant species selection, plant …

Reading Ondaatje's Poetry, Eluned Summers-Bremner

CLCWeb: Comparative Literature and Culture

Eluned Summers-Bremner pursues in her paper "Reading Ondaatje's Poetry" a psychoanalytic reading of Ondaatje's poetry based on Lacan's thought, highlighting occasions where nature and culture meet. Focusing on the volumes Secular Love and The Man with Seven Toes, Summers-Bremner explores how nature's troubled regions are navigated through the structural estrangement of looking for a name. In Lacanian terms, a proper name signals the contradiction of one's belonging to a biological or other kind of family, whence one's name often arises, and being a user or respondent of language, which produces meaning through its infringement or exceeding of its users' intentions, …

Ondaatje's The English Patient And Rewriting History, Stephanie M. Hilger

CLCWeb: Comparative Literature and Culture

Stephanie M. Hilger, in her paper "Ondaatje's The English Patient and Rewriting History," situates the novel within the long-standing Western tradition of writing about the cultural "Other," from Herodotus to Michel de Montaigne to Rudyard Kipling. Michel de Certeau's notion of history serves as a reference point for the analysis of Ondaatje's presentation of the "English" patient's story as well as of twentieth-century history. Hilger argues that the protagonist's physical mutilation is a metonymic representation of post-World War II and postcolonial consciousness. In the same way that the characters in the novel attempt to understand the mystery that is the …

Selected Bibliography Of Michael Ondaatje's Texts And Studies About Michael Ondaatje's Texts, Steven Tötösy De Zepetnek

CLCWeb: Comparative Literature and Culture

No abstract provided.

Representations Of Buddhism In Ondaatje's Anil's Ghost, Marlene Goldman

CLCWeb: Comparative Literature and Culture

Marlene Goldman suggests in her paper "Representations of Buddhism in Ondaatje's Anil's Ghost" that at first glance Ondaatje appears to promote the idea of a Sri Lankan Buddhist faith as transcending history. Ondaatje introduces the subject of Buddhism early on in the novel, emphasizing initially the devastation wrought by imperial and colonial forces. Goldman, however, argues that subsequent references to Buddhism undermine the initial portrayal of a religion besieged by external imperialist forces. For example, at one point, the character Palipana refers to the assassination of his brother, Narada, a Buddhist monk. Narada was possibly the victim of a "political …

The Motif Of The Collector And History In Ondaatje's Work, Jon Saklofske

CLCWeb: Comparative Literature and Culture

Jon Saklofske, in his paper "The Motif of the Collector and History in Ondaatje's Work" recognizes that Ondaatje rescues Buddy Bolden from historical obscurity by elevating and complicating the musician's largely forgotten history with a self-conscious and largely fictional synthesis of memory and imagination. The liberties Ondaatje takes in Coming Through Slaughter with his subject to achieve this re-presentation and the ownership of the portrait that results exposes this type of authorial activity as a problematic appropriation. Saklofske suggests that to understand the implications of Ondaatje's activity it is useful to compare his efforts with Walter Benjamin's "collector" figure, who …

Innovations Affecting Us -- Extending The Life-Cycle Of Optical Media, Norman Desmarais

Against the Grain

No abstract provided.

Introduction To Comparative Cultural Studies And Michael Ondaatje's Writing, Steven Tötösy De Zepetnek

CLCWeb: Comparative Literature and Culture

No abstract provided.

Improving Throughput By Link Distance Control In A Multi-Rate Ad Hoc Network, Xiaoxin Wu, Gang Ding, Bharat Bhargava, Shan Lei

Department of Computer Science Technical Reports

No abstract provided.

Quality-Aware Replication Of Multimedia Data, Yi-Cheng Tu, Sunil Prabhakar

Department of Computer Science Technical Reports

No abstract provided.

Calcium And Vitamin D Increase Mrna Levels For The Growth Control Hik1 Channel In Human Epidermal Keratinocytes But Functional Channels Are Not Observed., Vlasios Manaves, Wuxuan Qin, Amy L. Bauer, Sandra S. Rossie, Masakazu Kobayashi, Stanley G. Rane

Department of Biochemistry Faculty Publications

Background

Intermediate-conductance, calcium-activated potassium channels (IKs) modulate proliferation and differentiation in mesodermal cells by enhancing calcium influx, and they contribute to the physiology of fluid movement in certain epithelia. Previous reports suggest that IK channels stimulate proliferative growth in a keratinocyte cell line; however, because these channels indirectly promote calcium influx, a critically unique component of the keratinocyte differentiation program, an alternative hypothesis is that they would be anti-proliferative and pro-differentiating. This study addresses these hypotheses.

Methods

Real-time PCR, patch clamp electrophysiology, and proliferation assays were used to determine if human IK1 (hIK1) expression and function are correlated with either …

A New Era In Library And Information Collaboration In New Zealand, Ainslie Dewe

Proceedings of the IATUL Conferences

The New Zealand government has signalled a new era for collaboration by establishing a Library and Information Advisory Commission (LIAC) under the National Library of New Zealand Act 2003. The statutory purpose of the Commission is to “provide advice to the Minister on library and information issues, including mātauranga Māori”. LIAC is required to take account of recent national and international developments in relation to library and information services. The promotion of collaboration in relation to protecting, preserving and promoting access to information is specifically listed as a key responsibility of LIAC. LIAC is an independent advisor to government via …

The Economics Of Services In Changing Environment, Arja-Riita Haarala

Proceedings of the IATUL Conferences

This presentation concentrates on the management issues associated with providing library and information services in a changing environment. The transition from print to digital media has been a success story in many countries. At the same time, libraries are under increasing pressure to justify their expenditure. An answer to the crucial question is needed: Does this expenditure in terms of costs and benefits justify the services delivered? Publishers have encouraged the new trend by offering resources in digital format at little or no additional cost to the print subscription, but how will it be the future. New pricing models are …

To Be Or Not To Be Together: Is There A Choice? (Keynote Paper), Elena Maceviciute

Proceedings of the IATUL Conferences

The paper aims to reflect on the aims of contemporary regional library co-operation, its reasons, forms and types of co-operation. It introduces the concept of regional co-operation, follows the historical development of its types, forms, models, and complexity. The emphasis is on the essential difference of modern library co-operation from earlier periods, its drivers and inhibitors, main actors and ultimate possibilities that is open as an intermediary level between local and international library work.

High-Density Off-Site Storage In North American Research Libraries, Scott Seaman

Proceedings of the IATUL Conferences

No abstract provided.

Drexel University, The University Of Maryland, And Their Libraries’ Experiences Collaborating With Various Research Programs, Jay Bhatt, John Meyer, Rafael Sidi

Proceedings of the IATUL Conferences

Last year, researchers and librarians at both Drexel University and the University of Maryland initiated similar collaborative projects in their respective institutions to contribute to the development of life-long learning skills among the select participants. One joint finding was the importance of linking advances in knowledge, not just as hypothetical learning that benefits an elite few, but rather for the advancement of our society as a whole. Drexel University has two NSF-supported programs, Research Experience for Teachers (RET) and the Research Experience for Undergraduates Site (REU) DREAM (Drexel Research Experience in Advanced Materials). RET’s primary goal is to provide experiential …

Internet In The Library - The Sky Isn't Blue, Błażej Feret, Barbara Szczepańska

Proceedings of the IATUL Conferences

In the past few years, libraries, including academic libraries, became not only a place in which users could find information supporting teaching and research, but also hubs for patron access to the Internet and its vast resources. However, the Internet is not a “good boy”, and the information easily found with search engines or peer-to-peer programs may be used for bad goals. Should academic libraries promote unrestricted access to the Internet for the sake of people’s right to open access to information, or should they rather restrict and filter the incoming information to that actually related to the subjects of …

'Digital Is Not Different' - Copyright In Digital Environment, Barbara Szczepańska

Proceedings of the IATUL Conferences

Development in technology has brought to the libraries new kind of resources. Digital works such as books, periodicals and other materials are now in libraries collections. In spite of the fact that basic principles of copyright remain the same for ”traditional” and digital works. Copyright in digital environment is much more difficult to control because of the ease of creation, modification and distribution of digital copies over networks. Libraries help copyright holders to protect digital works against copyright infringements. On the other hand they represent also users of protected materials, and have a crucial role to play in ensuring the …

Managing Staff Concerns And Expectations During A Library Merger, Adriaan Swanepoel

Proceedings of the IATUL Conferences

The purpose of this paper is to present and discuss results of a survey to measure concerns and expectations of library staff before and after a merger. The survey was done four months before a merger took place between three separate Technikons in South Africa, and it was repeated two months after the merger. The questionnaire that was used to gather information from all full-time library staff members of the three technikons included questions on how important it is for library staff, within the context of the merger, that certain work-related conditions stay the same, e.g. to have the same …

Library Collaboration: What Makes It Work? (Keynote Paper), Murray Shepherd

Proceedings of the IATUL Conferences

In previous papers delivered at IATUL Conferences, I described the TriUniversity Group (TUG) library collaboration. I spoke of the advantages and reported that three academic libraries, large (University of Waterloo) medium (University of Guelph) and small (Wilfrid Laurier University) were working together creatively to address a number of issues: • Remote storage of little used library materials, • Development of a web-based, unified and integrated online “catalogue”, • Joint purchases of online resources, and • Rationalization of information resources This pioneering collaborative undertaking, initiated in 1995, is now widely emulated, with some success. The TUG librarians found that collaboration is …

Optimization Of Ectopic Gene Expression In Skeletal Muscle Through Dna Transfer By Electroporation., Jordan Taylor, Charles F. Babbs, Mohammed Borhan Alzghoul, Aaron Olsen, Mickey Latour, Amber L. Pond, Kevin Hannon

Weldon School of Biomedical Engineering Faculty Publications

Background

Electroporation (EP) is a widely used non-viral gene transfer method. We have attempted to develop an exact protocol to maximize DNA expression while minimizing tissue damage following EP of skeletal muscle in vivo. Specifically, we investigated the effects of varying injection techniques, electrode surface geometry, and plasmid mediums.

Results

We found that as the amount of damage increased in skeletal muscle in response to EP, the level of β-galactosidase (β-gal) expression drastically decreased and that there was no evidence of β-gal expression in damaged fibers. Two specific types of electrodes yielded the greatest amount of expression. We also …

A Systemic Gene Silencing Method Suitable For High Throughput, Reverse Genetic Analyses Of Gene Function In Fern Gametophytes., George Rutherford, Milos Tanurdzic, Mitsuyasu Hasebe, Jo Ann Banks

Department of Botany and Plant Pathology Faculty Publications

Background

Ceratopteris richardii is a useful experimental system for studying gametophyte development and sexual reproduction in plants. However, few tools for cloning mutant genes or disrupting gene function exist for this species. The feasibility of systemic gene silencing as a reverse genetics tool was examined in this study.

Results

Several DNA constructs targeting a Ceratopteris protoporphyrin IX magnesium chelatase (CrChlI) gene that is required for chlorophyll biosynthesis were each introduced into young gametophytes by biolistic delivery. Their transient expression in individual cells resulted in a colorless cell phenotype that affected most cells of the mature gametophyte, including the …

Airline Quality Rating 2004, Brent D. Bowen, Dean E. Headley

Airline Quality Rating Report

The Airline Quality Rating (AQR) was developed and first announced in early 1991 as an objective method of comparing airline quality on combined multiple performance criteria. This current report, the Airline Quality Rating 2004, reflects monthly Airline Quality Rating scores for 2003. AQR scores for the calendar year 2003 are based on 15 elements in four major areas that focus on airline performance aspects important to air travel consumers.

The Airline Quality Rating 2004 is a summary of month-by-month quality ratings for U.S. airlines that have at least 1% of domestic passenger volume during 2003. Using the Airline Quality Rating …

Hyperfix: Coordination And Construction Of 33 Bridges And 35 Lane Miles In 55 Days, Gary Mroczka, M Sean Poerter, Tim Conarroe, Dan Rogers

Purdue Road School

No abstract provided.

Setting Rational Speed Limits, Cindy Coddington, Maria Drake

Purdue Road School

No abstract provided.

Indot Storm Water Management Plan, Tom Duncan

Purdue Road School

No abstract provided.

Three-Dimensional Imaging Of Living And Dying Neurons With Atomic Force Microscopy, Helen Mcnally, Richard B. Borgens

Other Nanotechnology Publications

Atomic Force Microscopy (AFM) has been used to image the morphology of developing neurons and their processes. Additionally, AFM can physically interact with the cell under investigation in numerous ways. Here we use the AFM to both three-dimensionally image the neuron and to inflict a nano/micro-puncture to its membrane. Thus, the same instrument used as a tool to precisely penetrate/cut the membrane at the nanoscale level is employed to image the morphological responses to damage. These first high resolution AFM images of living chick dorsal root ganglion cells and cells of sympathetic ganglion and their growing processes provide confirmation of …

Simulation Study Of A Cellular Aided Mobile Ad-Hoc Network, Gang Ding, Xiaoxin Wu, Bharat Bhargava, Shan Lei

Department of Computer Science Technical Reports

No abstract provided.

Shakespeare And The Visualization Of Metaphor In Two Chinese Versions Of Macbeth, Alexander C.Y. Huang

CLCWeb: Comparative Literature and Culture

In his paper, "Shakespeare and the Visualization of Metaphor in Two Chinese Versions of Macbeth," Alexander Huang proposes that, in addition to political uses, visualization is an important dimension of cultural translations of Shakespeare. In recent studies, Shakespeare's global presence has been investigated from various perspectives of critical inquiry, especially with postcolonial theories and in East-West literary relations. Instead of faulting cultural imperialism or foregrounding political statements in theatre, Huang explores the visual dimension of cultural translation found in Kingdom of Desire (a Beijing opera adaptation of Macbeth) and Story of the Bloody Hand (a Kunqu opera appropriation of the …