Digital Commons Network^™

Evaluation Of Targeted Influenza Vaccination Strategies Via Population Modeling., John Glasser, Denis Taneri, Zhilan Julie Feng, Jen-Hsiang Chuang, Peet Tüll, William Thompson, Mary Mccauley, James Alexander

Department of Mathematics Faculty Publications

Background

Because they can generate comparable predictions, mathematical models are ideal tools for evaluating alternative drug or vaccine allocation strategies. To remain credible, however, results must be consistent. Authors of a recent assessment of possible influenza vaccination strategies conclude that older children, adolescents, and young adults are the optimal targets, no matter the objective, and argue for vaccinating them. Authors of two earlier studies concluded, respectively, that optimal targets depend on objectives and cautioned against changing policy. Which should we believe?

Methods and Findings

In matrices whose elements are contacts between persons by age, the main diagonal always predominates, reflecting …

Genetic Transformation And Mutagenesis Via Ssdna In The Unicellular, Diazotrophic Cyanobacteria Of The Genus Cyanothece., Hongtao Min, Louis A. Sherman

Department of Biological Sciences Faculty Publications

We describe a genetic system for producing specific gene knockouts inCyanothece sp. strain PCC 7822 using a single-stranded DNA technique (B. Zorin, P. Hegemann, and I. Sizova, Eukaryot. Cell 4:1264-1272, 2005). The first fully segregated mutant was a ΔnifK mutant, and it was unable to grow on medium lacking combined nitrogen and produced virtually no hydrogen.

A Comparative Study Of Fat Storage Quantitation In Nematode Caenorhabditis Elegans Using Label And Label-Free Methods., Kelvin Yen, Thuc T. Le, Ankita Bansal, Sri Devi Narasimhan, Ji-Xin Cheng, Heidi A. Tissenbaum

Weldon School of Biomedical Engineering Faculty Publications

The nematode Caenorhabditis elegans has been employed as a model organism to study human obesity due to the conservation of the pathways that regulate energy metabolism. To assay for fat storage in C. elegans, a number of fat-soluble dyes have been employed including BODIPY, Nile Red, Oil Red O, and Sudan Black. However, dye-labeled assays produce results that often do not correlate with fat stores in C. elegans. An alternative label-free approach to analyze fat storage in C. elegans has recently been described with coherent anti-Stokes Raman scattering (CARS) microscopy. Here, we compare the performance of CARS microscopy …

At Brunning: People And Technology-At The Only Edge That Means Anything/How We Understand What We Do, Dennis Brunning

Against the Grain

No abstract provided.

Pelikan's Antidisambiguation-"The Role Of Agency In Content To Come", Michael P. Pelikan

Against the Grain

No abstract provided.

Japanese Science Fiction And Conceptions Of The (Human) Subject, Maria Poulaki

CLCWeb: Comparative Literature and Culture

In her article "Japanese Science Fiction and Conceptions of the (Human) Subject" Maria Poulaki discusses the crisis that almost all essentialist categorizations have been facing in late modernity, in the context of which science fiction texts offer fertile ground to investigate the transitions brought about with the intensified invasion of the "human self" by its "nonhuman other." The analysis of a Japanese science fiction film draws a seemingly paradoxical connection between the Japanese version of modernity and self-identity with the relevant "Western" articulations found in the work of Bruno Latour and Alain Badiou. This connection points at a broader re-conceptualization …

Group Therapy-Print Monographs With Complimentary Online Access, Jack G. Montgomery

Against the Grain

No abstract provided.

And They Were There-Reports Of Meetings, Ramune K. Kubilius

Against the Grain

No abstract provided.

From The Reference Desk-Reviews Of Reference Titles, Tom Gilson

Against the Grain

No abstract provided.

Atg Interviews Bipin Patel, Cio, Proquest, Katina Strauch, Leah Hinds

Against the Grain

No abstract provided.

A Consilient Science And Humanities In Mcewan's Enduring Love, Curtis D. Carbonell

CLCWeb: Comparative Literature and Culture

In his article "A Consilient Science and the Humanities in McEwan's Enduring Love" Curtis D. Carbonell provides a reading of a Third Culture novel that foregrounds the relationship of the sciences and the humanities. In Ian McEwan's novel we see a perfect example of how literary thinkers are listening to the world of science and speaking to it in return. This article responds to Stephen Greenberg's ideas about how Neo-Darwinian themes in the novel point to social themes by arguing that what underlies both of these is a deeper structure: the tension between C.P. Snow's Two Cultures, which is only …

Authorship, Collaboration, And Art Geography, Martin De La Iglesia

CLCWeb: Comparative Literature and Culture

In his article "Authorship, Collaboration, and Art Geography" Martin de la Iglesia explores the connection between geographical spaces and works of art, a connection often made, but hardly theorized, by scholars in the field of art geography. He suggests that the link between space and object is established by the creator of the object. A feasible method is devised to determine the creator's geographical identity, which in turn determines which space is assigned to the object. Particularly, the implications of multiple authorship for such a methodology are considered. The procedure is exemplified by a geographical analysis of the comic book …

Book Reviews-Monographic Musings, Debbie Vaughn

Against the Grain

No abstract provided.

The Metaphysics Of Electronic Being, Michał Ostrowicki [Aka Sidey Myoo]

CLCWeb: Comparative Literature and Culture

In his article "The Metaphysics of Electronic Being" Michał Ostrowicki discusses the electronic environment as a sphere of being. To this end, the notion of the "electronic sphere" is used as a subject of ontological analysis. Ostrowicki postulates that the problematics of the electronic sphere represents a part of ontology and designates it as "ontoelectronics." He makes a distinction made between an electronic image and an electronic being, thus indicating that they differ from each other in their existential status and thereby deny any metaphysical equivalence between the two. This distinction between an electronic image and an electronic being is …

About Intermedialities: A Review Article Of New Work By Paech And Schröter, Chapple And Kattenbelt, And Ellerström, Arno Gimber, Asunción López-Varela Azcárate

CLCWeb: Comparative Literature and Culture

No abstract provided.

Involvement Of Tip60 Acetyltransferase In Intracellular Salmonella Replication., Xueqin Wang, Dongju Li, Di Qu, Daoguo Zhou

Department of Biological Sciences Faculty Publications

Background

Salmonella enterica is a facultative intracellular pathogen that replicates within a membrane-bound compartment termed Salmonella containing vacuole (SCV). The biogenesis of SCV requiresSalmonella type III protein secretion/translocation system and their effector proteins which are translocated into host cells to exploit the vesicle trafficking pathways. SseF is one of these effectors required for SCV formation and Intracellular Salmonella replication through unknown mechanisms.

Results

In an attempt to identify host proteins that interact with SseF, we conduct a yeast two-hybrid screening of human cell cDNA library using SseF as the bait. We identified that TIP60, an acetyltransferase, interacts with SseF. …

Simulation Of Sub-Micron Thermal Transport In A Mosfet Using A, James Loy, Druv Singh, Jayathi Y. Murthy

PRISM: NNSA Center for Prediction of Reliability, Integrity and Survivability of Microsystems

Self-heating has emerged as a critical bottleneck to scaling in modern transistors. In simulating heat conduction in these devices, it is important to account for the granularity of phonon transport since electron-phonon scattering occurs preferentially to select phonon groups. However, a complete accounting for phonon dispersion, polarization and scattering is very expensive if the Boltzmann transport equation (BTE) is used. Moreover, difficulties with convergence are encountered when the phonon Knudsen number becomes small. In this paper we simulate a two-dimensional bulk MOSFET hotspot problem using a partially-implicit hybrid BTE-Fourier solver which is significantly less expensive than a full BTE solution, …

Metric Signature Transitions In Optical Metamaterials, Igor Smolyaninov, Evgenii Narimanov

Birck and NCN Publications

We demonstrate that the extraordinary waves in indefinite metamaterials experience an (- - + +) effective metric signature. During a metric signature change transition in such a metamaterial, a Minkowski space-time is created together with a large number of particles populating the space-time. Such metamaterial models provide a tabletop realization of metric signature change events suggested to occur in Bose-Einstein condensates and quantum gravity theories.

Evaluation Of Toxicity Analysis For Foundry Sand Specifications, M. Katherine Banks, A. Paul Schwab

JTRP Technical Reports

Byproducts from many industries have the potential to be used as construction materials, but some means is required to determine if the material is environmentally benign. Foundry sands are produced in many states and can be useful as in transportation projects. However, INDOT currently requires the use of the MICROTOX test to assess the potential toxicity of the sands, and this requirement is viewed as an unnecessary impediment by the producers of foundry sands and is a requirement not encountered in other states. Therefore, the goal of this project was to review current requirements for testing of recycled materials, determine …

Microcantilever Dynamics In Liquid Environment Dynamic Atomic Force Microscopy When Using Higher-Order Cantilever Eigenmodes, Daniel Kiracofe, Arvind Raman

Birck and NCN Publications

Dynamic atomic force microscopy is currently evolving from a single to a multifrequency instrument for nanoscale imaging often employing higher-order microcantilever eigenmodes for improved resolution and force spectroscopy. In this work the authors study the fundamentals of cantilever dynamics and energy dissipation when soft cantilevers are driven at their second flexural eigenmode and interact with samples in liquid environments. Contrary to the conventional first eigenmode operation, second eigenmode operation in liquids is often dominated by a subharmonic response (e.g., one tap every four drive cycles) and there is an energy transfer to the first eigenmode creating a new channel of …

Objectives And Outcomes In Risk Management Education, Padmavathi Koutha

Purdue Polytechnic Directed Projects

Since the advent of the Personal Computer in the 1980’s, the Information Technology (IT) industry has ballooned into one of the largest employers of people across the world. However, IT projects have constantly been plagued with low success rates. Analysis of these project failures has revealed lack of knowledge of risk management practices and tools as a key reason for unsuccessful projects.

This project focused on the development of a graduate level course in Information Technology risk management for incorporation into the graduate level curriculum at the department of Computer and Information Technology at Purdue University. A Problem learning model …

User Interfaces For Simultaneous Group Collaboration Through Multi-Touch Devices, Frank Joseph Garofalo

Purdue Polytechnic Directed Projects

Through a qualitative investigation using the phenomenological approach, this research study will explored the lived experience of individuals using a multi-touch interface and device for a group collaboration activity in a shared workspace. The research question was “what is the experience of users interacting simultaneously to complete a common task, with the display output of a multi-touch device?” Two rounds of user testing of approximately three participants for each respective round, performed a Six Sigma Affinity Diagram exercise using a multi-touch device. The exercise was a brainstorming component to the Six Sigma process in which qualitative data is sorted into …

Movement Of Proteins - Purdue University, Jake R. Carlson

Data Curation Profiles Directory

This data curation profile focuses on a researcher’s study of the positions and movement of protein molecules within a cell. The protein molecules are derived from jellyfish and inserted into E. coli cells to identify the pathways taken by the protein and cell mechanics. The researcher also examines how genetic modifications and mutations affect the movement of the protein. The data management needs relate to how the researcher can effectively manage, curate, and share his data given the large size of his data. The researcher also shared a need for better methods of backing up his data and for an …

Live Migration Of Parallel Applications, Raul Fabian Romero

Purdue Polytechnic Masters Theses

Romero, Raul F. M.S., Purdue University, August, 2010. Live Migration of Parallel Applications. Major Professor: Thomas J. Hacker.

It has been observed on engineering and scientific data centers that the absence of a clear separation between software and hardware can severely affect parallel applications. Applications that run across several nodes tend to be greatly affected because a single computational failure present in one of the nodes often leads the entire application to produce incorrect results or to even die. This low observed reliability requires a combination of a proactive and reactive solution in order to preserve the state of parallel …

Acoustic And Electrical Property Changes Due To Microbial Growth And Biofilm Formation In Porous Media, C. A. Davis, L. J. Pyrak-Nolte, E. A. Atekwana, D. D. Werkema, M. E. Haugen

Department of Physics and Astronomy Faculty Publications

A laboratory study was conducted to investigate the effect of microbial growth and biofilm formation on compressional waves, and complex conductivity during stimulated microbial growth. Over the 29 day duration of the experiment, compressional wave amplitudes and arrival times for the control (nonbiostimulated) sample were observed to be relatively uniform over the scanned 2-D region. However, the biostimulated sample exhibited a high degree of spatial variability in both the amplitude and arrival times, with portions of the sample exhibiting increased attenuation (similar to 80%) concurrent with an increase in the arrival times, while other portions exhibited decreased attenuation (similar to …

Bibliography For Work In Travel Studies, Carlo Salzani, Steven Tötösy De Zepetnek

CLCWeb Library

No abstract provided.

Making The Transition From Text To Data Repositories, Julie Sweetkind-Singer, Robert Schwarzwalder

International Association of Scientific and Technological University Libraries, 31st Annual Conference

Stanford University Libraries & Academic Information Resources (SULAIR) has been a national leader in developing repository strategies for digital text and image files. Stanford University Libraries began work on long-term preservation and access to geospatial data over five years ago after being awarded a Library of Congress grant through the National Digital Information Infrastructure & Preservation Program (NDIIPP). The desire to build on this expertise led to an initiative two years ago to develop a strategy for acquiring, preserving, managing and providing services for a broader range of scientific and technical data. Progress to date has included: a better understanding …

The Sdss And E-Science Archiving At The University Of Chicago Library, Barbara Kern, Dean Armstrong, Charles Blair, David Farley, Kathleen Feeney, Eileen Ielmini, Elisabeth Long, Daniel Meyer, Peggy Wilkins

International Association of Scientific and Technological University Libraries, 31st Annual Conference

The Sloan Digital Sky Survey (SDSS) is a co-operative scientific project involving over 25 institutions worldwide and managed by the Astrophysical Research Consortium (ARC) to map one- quarter of the entire sky in detail, determining the positions and absolute brightness of hundreds of millions of celestial objects. The project was completed in October 2008 and produced over 100 terabytes of data comprised of object catalogs, images, and spectra. While the project remained active, SDSS data was housed at Fermilab. As the project neared completion the SDSS project director (and University of Chicago faculty member) Richard Kron considered options for long …

The E-Research Center: Transforming A Traditional Science Library, Martha Bedard, Johann Van Reenen

International Association of Scientific and Technological University Libraries, 31st Annual Conference

At the University of New Mexico Libraries (UL) a year long process engaged faculty, students and library personnel in developing a new mission for the Centennial Science and Engineering Library (CSEL) that will re-purpose it to serve the evolving need for facilitating e-research. The authors discuss the vision of the UL for being at the center of data intensive and cyber-enabled research and the planned development of the eResearch Center (eRC). They share the planning process and ideas to revitalize a 25 year old science and engineering library into a collaborative transdisciplinary research hub. Plans include installing low-latency and high-availability …

Get On Your Boots: A Model For Low-Cost, Regional Professional Development For Science Librarians At The University Of Massachusetts, Maxine Schmidt, Rebecca Reznik-Zellen

International Association of Scientific and Technological University Libraries, 31st Annual Conference

The University of Massachusetts Five Campus System Science Librarians organized a low-cost, regional professional development program as part of a response to state-wide life science initiatives. Science Boot Camp for Librarians was envisioned as a casual but intensive immersion event into selected scientific subjects that employ networked computing capabilities for research and collaboration. The goal of the event was to provide librarians with subject awareness and networking opportunities to enable them to better engage faculty and research scientists with regard to e-science. This article focuses on the planning and execution of the event as an example of a successful, grass-roots …