Digital Commons Network^™

A Scoping Review Of Population Diversity In The Common Genomic Aberrations Of Clear Cell Renal Cell Carcinoma, Sean S. Kumar, Ninad Khandekar, Komal Dani, Saina R. Bhatt, Vinay Duddalwar, Anishka D' Souza

Department of Medicine Faculty Publications

Introduction: Previous literature has shown that clear cell renal cell carcinoma (ccRCC) is becoming a more prevalent diagnosis and that the incidence and mortality differ both regionally and racially. While the molecular profiles for ccRCC are studied regionally through biopsy and sequencing techniques, the genomic landscape and ccRCC diversity data are not well studied. We conducted a review of the known genomic data on 6 of the most clinically relevant DNA biomarkers in ccRCC: von Hippel-Lindau (vHL), Polybromo-1 (PBRM1), Breast Cancer Gene 1-Associated Protein 1 (BAP1), Histone-Lysine N-Methyltransferase Domain-Containing 2 (SETD2), Mammalian Target of Rapamycin (mTOR), and Lysine-Specific Demethylase 5C …

Environmentally Friendly Chelation For Enhanced Algal Biomass Deashing, Agyare Asante, George Daramola, Ryan W. Davis, Sandeep Kumar

Civil & Environmental Engineering Faculty Publications

High ash content in algal biomass limits its suitability for biofuel production by reducing combustion efficiency and increasing fouling. This study presents a green deashing strategy using nitrilotriacetic acid (NTA) and deionized (DI) water to purify Scenedesmus algae, which was selected for its high ash removal potential. The optimized sequential treatment (DI, NTA chelation, and DI+NTA treatment at 90–130 °C) achieved up to 83.07% ash removal, reducing ash content from 15.2% to 3.8%. Elevated temperatures enhanced the removal of calcium, magnesium, and potassium, while heavy metals like lead and copper were reduced below detection limits. CHN analysis confirmed minimal …

Old Dominion University Libraries Annual Report 2024-2025, Jennifer Hoyt, Alisa Faumore, Alex Aycock

Libraries Reports and Documents

Annual Report of the Old Dominion University Libraries for FY 2024-2025.

The report was written by the Libraries' Department of Engagement:

• Jennifer Hoyt, Head of Libraries’ Engagement
• Alisa Faumore, Communications Coordinator
• Alex Aycock, Assistant Communications Coordinator

Excitation And Polarization Of Isolated Neurons By High-Frequency Sine Waves For Temporal Interference Stimulation, Iurii Semenov, Vitalii Kim, Giedre Silkuniene, Andrei G. Pakhomov

Bioelectrics Publications

The capacity of temporal interference (TI) stimulation to target deep brain regions without affecting nearby surface electrodes remains uncertain. Using artifact-free optical recording, we compare excitation patterns and thresholds in hippocampal neurons stimulated by “pure” and amplitude-modulated sine waves, representing TI waveforms near electrodes and at the target, respectively. We show that pure 2- and 20-kHz sine waves induce repetitive firing at rates that increase up to 60–90 Hz with stronger electric fields. Beyond this limit, action potentials merge into sustained depolarization, resulting in an excitation block. Modulating the sine waves at 20 Hz aligns firing with amplitude “beats” and …

Low-Charge, High-Resolution Beamline Preparation For The Nanopatterned Microbunching Experiment At Argonne Wakefield Accelerator, R. Margraf-O'Neal, A. Ody, J. Power, J. Hlavenka, B. N. Temizel Ozdemir, G. Andonian, B. Carlsten, A. Desimone, G. Ha, A. Halavanau, H. Xu, N. Majernik, J. M. Maxson, A. Parrack, R. Ryne, M. Yadav, N. Yampolsky, J. Rosenzweig

Physics Faculty Publications

The emittance exchange (EEX) beamline at the Argonne Wakefield Accelerator (AWA) is designed to transfer properties of an electron beam phase space between the transverse and longitudinal planes. Recently, it has been proposed this beamline could be used to convert a microscale transverse modulation created by a TEM grid into a microbunch train in the longitudinal plane. Such a technique would be useful for obtaining nano-scale microbunching that does not rely on the sensitive process of FEL gain. This new approach has been proposed to enable development of a compact free-electron laser at Arizona State, greatly reducing size and cost …

Design Of A Shipping Fixture For A Compact Cryomodule Hermetic Assembly, J. Lewis, G. Ciovati, N. Huque, J. Armstrong, K. Harding

Physics Faculty Publications

Two conduction-cooled 915 MHz superconducting radio frequency hermetic assemblies must be safely transported from the Jefferson Lab in Newport News, VA to General Atomics in San Diego, CA for performance testing in a custom horizontal test cryostat. One hermetic assembly consists of a 2-cell 915 MHz cavity, a coaxial fundamental power coupler, and the warm-to-cold transition beam tubes. The second hermetic assembly consists of a 2-cell 915 MHz cavity only. The assemblies will be transported on a flatbed air-ride trailer over the approximate 4000 km distance. Design requirements included adequate attenuation of 4g vertical axis, 5g beamline axis, and 1.5g …

A Time-Domain Boundary Integral Equation For Moving Acoustic Sources In Uniform Flow And Its Solution By An Advanced Time Propagation Approach, Fang Q. Hu, Douglas M. Nark

Mathematics & Statistics Faculty Publications

This paper presents a time-domain boundary integral equation (TDBIE) formulation for predicting acoustic scattering from moving sources in a uniform mean flow. This work is motivated by the increasing need for accurate aeroacoustic modeling of modern aircraft configurations, including VTOL and eVTOL systems with rotating components. A key challenge in time-domain scattering simulations with moving sources is the determination of retarded time for a given observer time, which involves solving an implicit equation at each time step. This can be computationally costly, particularly for numerical solution of the TDBIE where every surface element on the scattering body acts as an …

Laser-Induced Graphene For Early Disease Detection: A Review, Sri Ramulu Torati, Gymama Slaughter

Center for Bioelectronics Publications

Electrochemical biosensors have been instrumental in early disease detection, facilitating effective monitoring and treatment. The emergence of graphene has significantly advanced sensor technology in various fields, including biomedicine, electronics, and energy. In this landscape, laser‐induced graphene (LIG) has emerged as a superior alternative to conventional graphene synthesis methods. Its straightforward fabrication process and compatibility with wearable devices boost its practicality and potential for real‐world applications. This review highlights the transformative potential of LIG in biosensing, showcasing its contributions to the development of next‐generation diagnostic tools for early disease detection. An overview of the LIG synthesis process and its applications in …

An Electrochemical Sensor For Tenofovir Monitoring, Abdellatif Ait Lahcen, Gymama Slaughter

Center for Bioelectronics Publications

Effective monitoring of tenofovir (TFV) adherence is critical for ensuring the success of antiretroviral therapies in preventing and managing HIV, as nonadherence can lead to treatment failure and the development of drug-resistant strains. In this study, a highly sensitive and selective novel biomimetic sensor for TFV determination is developed utilizing laser-scribed graphene (LSG) modified with gold spiky nanostructures (AuNSp) and molecularly imprinted polymer (MIP). The MIP layer is engineered with precise control to maximize molecular specificity for TFV. Electrochemical characterization demonstrates excellent performance, including the broadest linear detection range (10 nM to 200 μM) reported to date with a sensitivity …

Women's And Men's Authorship Experiences: A Prospective Meta Analysis, George C. Banks, Lisa M. Rasmussen, Scott Tonidandel, Jeffrey M. Pollack, Mary M. Hausfeld, Courtney Williams, Betsy H. Albritton, Joseph A. Allen, Nicolas Bastardoz, John H. Batchelor, Andrew A. Bennett, Roman Briker, Christopher M. Castille, Bart A. De Jong, Elise Demeter, Justin A. Desimone, James G. Field, Maria Figueroa-Armijos, M. Fernanda Garcia, William L. Gardner, J. Jeffrey Gish, Laura M. Giurge, Claudia N. Gonzalez-Brambila, M. Gloria González-Morales, Lorenz Graf-Vlachy, Roopak Kumar Gupta, Amanda S. Hinojosa, Zion Howard, Sven Kepes, Tine Köhler, Dejun Tony Kong, Markus Langer, Teng Lat Loi, Liam P. Maher, Chao Miao, Murad A. Mithani, Lakshmi Balachandran Nair, William G. Obenauer, Ernest H. O'Boyle, Jason R. Pierce, Deborah M. Powell, Roni Reiter-Palmon, Deborah E. Rupp, Srinivasan Tatachari, Jane S. Thomas, Tiia Vissak, Jako Volschenk, Chen Wang, Christopher E. Whelpley, Hans-Georg Wolff, Haley M. Woznyj, Tao Yang

Management Faculty Publications

The opaqueness of author naming and ordering, when coupled with power dynamics, can lead to a number of disadvantages in academic careers. In this commentary, we investigate gender differences in authorship experiences in a large prospective meta-analytic study (k = 46; n = 3,565; 12 countries). We find that women’s and men’s authorship experiences differ significantly with women reporting greater prevalence of problematic behaviors. We present seven actionable recommendations for improving the receipt and reporting of intellectual credit. Such actions are needed to ensure fairness in authorship, which is one of the most powerful factors in academics’ career outcomes.

Behavioral Health Training For Integrated Behavioral Health: A Delphi Study, Nicholas Schmoyer, Lisa Corbin, Jessica Huffman, Gülşah Kemer

Counseling & Human Services Faculty Publications

Using a classical Delphi design, the authors used an interdisciplinary panel of behavioral health experts in integrated behavioral health (IBH) to identify foundational skills and knowledge counselor educators need to teach clinical mental health counselors for IBH practice. Eighty-eight statements were identified. Implications are provided for counseling and other behavioral health educators.

Engaging The Community, Providing Hopes, Mackenzie Peeke, Margaret West, Alyssa Wilkinson, Matthew Serrata, Michael Baroody, Conner Tembe, Chrisney Yerena

HOPES Free Clinic Publications

Founded in the 1970s as a grassroots effort to provide care to the underserved population of Hampton Roads, Eastern Virginia Medical School (EVMS) has long been committed to community-centered care. The HOPES Free Clinic is a manifestation of that mission. Launched in 2011 as a student-run phone triage service, the Health Outreach Partnership of EVMS Students (HOPES) later transitioned to provide direct clinical services—becoming the first student-run free clinic in the Commonwealth of Virginia. In 2014, HOPES integrated into Community Engaged Learning to enhance and solidify its efforts. Since its inception, medical and health professions students have partnered with volunteer …

Barriers And Facilitators To Accessing Mental And Physical Health Care Among Sexual Minority Women: A Qualitative Exploration, Charlotte A. Dawson, A. Moulder, Kristin E. Heron

Department Psychiatry & Behavioral Science Faculty Publications

Cisgender sexual minority women (SMW, e.g., lesbian, queer) are at greater risk for poor mental and physical health compared to heterosexual women and face challenges when accessing health care. Previous research has largely focused on general sexual and gender minority barriers to health care, but more research is needed on the experiences of specific subgroups, including cisgender SMW. The current study qualitatively explored barriers and facilitators for cisgender SMW seeking health care. Twenty cisgender SMW aged 18-40 recruited using Meta advertisements and past participant lists completed 45 min semi-structured interviews and a brief survey. Thematic analysis conducted by two coders …

Teaming With Technology: Adaptive Automation In Joint Cognitive Systems For Industry 5.0, Jessica Johnson

Virginia Digital Maritime Center (VDMC) Faculty Publications

Adaptive automation enables dynamic reallocation of functions between people and autonomous agents to improve performance in complex work. This paper presents a meta-analysis of experimental and quasi-experimental studies (2000-2025) on joint cognitive systems in industrially relevant contexts, quantifying effects on task performance, safety/failure management, workload, trust, and learning. Across studies, adaptive automation reliably reduces operator workload and shows moderate gains in task performance and safety, with healthier trust dynamics when adaptations are triggered by human-state or event cues, made transparent to the user, and remain rapidly overridable. Risks emerge when performance-triggered switching is opaque or poorly timed, which can erode …

Proactive Distributed Emergency Response With Heterogeneous Tasks Allocation, Justice Darko, Hyoshin Park

Engineering Management & Systems Engineering Faculty Publications

Traditionally, traffic incident management (TIM) programs coordinate the deployment of emergency resources to immediate incident requests without accommodating the interdependencies on incident evolutions in the environment. However, ignoring these inherent interdependencies while making current deployment decisions is shortsighted, and the resulting naive deployment strategy can significantly worsen the overall incident delay impact on the network. The interdependencies on incident evolution in the environment, including those between incident occurrences and those between resource availability in near-future requests and the anticipated duration of the immediate incident request, should be considered through a look-ahead model when making current-stage deployment decisions. This study develops …

Integrating Data Management Plans Into The Unified Architecture Framework Standards Views, Cansu Yalim, Holly A. H. Handley

Engineering Management & Systems Engineering Faculty Publications

System Architecting translates an operational concept into a model of the system to be realized. There is a need for a Data Management Plan (DMP) to be included in the overall system engineering process with the advent of Digital Engineering. Data longevity, accessibility, and integrity can all be improved throughout the system's lifecycle by a well-defined DMP. System engineers use an architecture framework to arrange the system data into several sets of viewpoints. Incorporating a DMP at this point specifies the procedures for gathering, storing, retrieving, and maintaining data to ensure that all interested parties have access to current, correct …

Computer Science For Middle School (Cs4ms), Melani Loney, Lisa Steffian, Tancy J. Vandecar-Burdin

Center for Educational Partnerships Publications

This session will discuss the project Computer Science for Middle School and the associated findings. This Virginia Department of Education funded project provides computer science Professional Development opportunities for in-service teachers, located in Southeastern Virginia, who instruct students in middle school grades 6- 8. Participating teachers learn to integrate computer science standards into core and elective content through online, asynchronous microcredentials and in-person Summer Workshops. The presentation will include project findings and next steps including teacher efficacy for implementing the computer science standards before and after completing the microcredentials and their students’ attitudes about computer science.

The Legend Of Taylor Heinicke: An Autoethnography Of Unexpected, Passionate Fandom, Brendan O'Hallarn

Communication & Theatre Arts Faculty Publications

Passionate fandom is not a novel phenomenon in the field of sport. The fervor of fans builds stadiums and has allowed the sport industry to grow exponentially in the past few decades. Scholars have examined the passionate fan through many theoretical lenses, but comparatively little scholarship has looked at sport fandom fervor from inside. An autoethnographic examination of my unexpected journey as a fan of journeyman National Football League (NFL) quarterback Taylor Heinicke demonstrates how fandom can stir passions and create rituals in sport followers. A multimedia diary of Heinicke's unexpected ascension to starting quarterback of the Washington Commanders provides …

A Comparative Analysis Of Stress Relief, Life Satisfaction, And Quality Of Life Based On Marriage Status And Gender Among Members Of Society Participating In Exercise, Ji-Hye Yang, Sicheol Jung, Hyejin Yang, Chulhwan Choi, Chul-Ho Bum

Human Movement Studies & Special Education Faculty Publications

Modern members of society tend to feel stressed in their workplace and at home, but exercising has been shown to effectively reduce stress and increase quality of life and satisfaction. This study aimed to investigate and compare stress relief, life satisfaction, and quality of life based on marriage status and gender among members of society who participate in exercise. We used a questionnaire survey with 311 participants, and the data were analyzed using descriptive statistics, validity and reliability, a multivariate analysis of variance (MANOVA), and a post hoc analysis. The study results showed that the single groups demonstrated higher mean …

Examining The Socioemotional Outcomes Of Social Justice Efforts On Social Media Users: Evidence From The Nfl's Inspire Change Initiatives, Yoseph Z. Mamo, Justin Haegele, Christos Anagnostopoulos, Kwame Agyemang

Human Movement Studies & Special Education Faculty Publications

Despite the growing interest in social justice activities, there is a lack of empirical evidence regarding their impact on various stakeholders, particularly social media users. We gathered longitudinal data from the NFL's @inspirechange X (former Twitter) account, a designated social justice communication handle, between August 2019 and March 2023. During this timeframe, the account garnered 20,967 comments (including original tweets and retweets) from 11,481 distinct users, but our analysis focused on 5851 comments deemed usable from 3632 unique users. Drawing on the social exchange theory, sentiment analysis, and thematic analysis, this study examines social media users' sentiments toward the NFL's …

Drone Medical Package Delivery For Improved Transportation And Better Patient Outcomes Final Implementation Report, Amro El-Adle, Madeline Alden, Yin-Hsuen Chen, Melissa Davidson

Information Technology & Decision Sciences Faculty Publications

The Drone Medical Package Delivery for Improved Transportation and Better Patient Outcomes planning and prototyping grant involves five partners, including Accomack-Northampton Planning District Commission (A-NPDC), Riverside Health System, Old Dominion University (ODU), Virginia Institute for Spaceflight & Autonomy (VISA), Virginia Innovation Partnership Corporation (VIPC), and DroneUp. The partners worked together to address access, safety, reliability and sustainability for medical and emergency response package delivery via drone, specifically, where the use of aerial drones could lead to better patient outcomes and improved safety and emergency response.

The goal of the project was to develop an operational prototype that woul evolve into …

Fares On Fairness: Using A Total Error Framework To Examine The Role Of Measurement And Representation In Training Data On Model Fairness And Bias, Patrick Oliver Schenk, Christoph Kern, Trent D. Buskirk

Information Technology & Decision Sciences Faculty Publications

Data-driven decisions, often based on predictions from machine learning (ML) models are becoming ubiquitous. For these decisions to be just, the underlying ML models must be fair, i.e., work equally well for all parts of the population such as groups defined by gender or age. What are the logical next steps if, however, a trained model is accurate but not fair? How can we guide the whole data pipeline such that we avoid training unfair models based on inadequate data, recognizing possible sources of unfairness early on? How can the concepts of data-based sources of unfairness that exist in the …

The Effect Of Liquid Conductivity On A Helium Plasma Jet And The Hydrogen Peroxide Production, Edwin A. Oshin, M. Ziaur Rahman, Chunqi Jiang

Bioelectrics Publications

Understanding plasma-liquid interactions and the impact of the electrical conductivity (σ) of liquid on plasma is important for plasma applications in water treatment and medicine. Ultrapure water, phosphate-buffered saline (PBS) solution, biological media, and sodium chloride (NaCl) solutions at various concentrations were used in this study to provide a broad range of conductivity values ranging from 0.055 μS cm⁻¹ to 222 mS cm⁻¹. A helium atmospheric pressure plasma jet (APPJ) impinging on liquid was generated in ambient air using a hollow-needle electrode that was powered by 200 ns, 7 kV pulses at a pulse repetition frequency of …

Determining The Transient Electric Field And The Effect Of Pulse Repetition Frequency On The Field In A Repetitive 10-Ns Pulsed Discharge In A Quiescent Ch₄-Air Mixture, Chunqi Jiang

Bioelectrics Publications

The goal of this research is to understand the underlying physics enabled by nanosecond pulsed power in a discharge initiation and the following physicochemical processes that favor lean-fuel plasma ignition for combustion. The hypothesis of this project is that pulsed power waveforms such as the pulse repetition frequency (PRF), voltage amplitude, and dielectric surface alter the reduced electric field during the initiation of the discharge, resulting in different plasma properties, which will vary the physicochemical processes for efficient and selective radical productions. This is especially important for lean-burn combustion and reducing emission.

Human Perception Of Ai Capabilities At Classifying Perturbed Roadway Signs, Katherine R. Garcia, Jing Chen, Yanru Xiao, Scott Mishler, Cong Wang, Bin Hu

Psychology Faculty Publications

Artificial Intelligence (AI) is crucial to numerous functions required for driving automation systems, including the computer vision techniques used to detect the roadway environment and make real-time decisions. However, the images used as inputs to the AI system may be maliciously perturbed, or manipulated, causing the AI system to make an incorrect classification. In this study, we examined humans’ perception of the AI’s computer vision capability of classifying various road sign images, including the original images, images with two different types of malicious attacks, and images that are scrambled randomly at the pixel level. Our results showed that participants rated …

"Queens Of Ghost-Land" 134 Years Later: Un-Masking An Appalachian Witchcraft Accuser, Aíne Norris

English Faculty Publications

In 1891, newspapers across America printed a story about witches in the Appalachian Mountains and the alleged powers they possessed to control their small farming community. The article was scathing in accusation and ultimately contributed to continued othering of the women profiled, increasing their visible vulnerabilities of class, gender, and societal status. Despite an implied familiarity with the region, the article was published with initials for its byline, an act that simultaneously identified the author to locals as historian Eva Grant while offering her anonymized national protection as a subject expert. For over five years the accusations were re-printed in …

Dynamic Stability Test Technique For Blunt Bodies In A Magnetic Suspension And Balance System, Caleb Hull, Colin Britcher, Dave E. Cox, Mark Schoenenberger, Hisham M. Shehata

Mechanical & Aerospace Engineering Faculty Publications

Techniques for the measurement of subsonic dynamic stability derivatives of blunt-body re-entry capsules are being developed using a Magnetic Suspension and Balance System at NASA Langley Research Center. The measured aerodynamics of a 45-degree sphere-cone similar to configurations being considered for Mars Sample Return Earth Entry Vehicle are reported. A novel test method has been developed where forced oscillatory translation of a test article is used to excite yaw attitude oscillations. The forced motion is then halted to observe free-to-oscillate behavior of the test article. Parameter identification methods are used to extract static and dynamic yawing moment stability characteristics from …

Fault Tree Analysis For Robust Design, Jonathan Degroff, Gene Jean-Win Hou

Mechanical & Aerospace Engineering Faculty Publications

The objective of this research is to incorporate system failure into a robust design formation and solution process. The system failure referred to here will be built using fault tree analysis (FTA), which will take all lower-level failure events into consideration. Two examples are investigated here. One will directly treat the probabilities of the basis events as design variables, The other will be formulated in five different models: deterministic design optimization, the reliability index-based, the “and” gate-based, the “or” gate-based and the “inhibit” gate-based robust design. Their corresponding optimization solutions will be compared with each other. The post-optimality analysis of …

Polarized Positrons At Ce⁺Baf, A. Ushakov, J. Benesch, M. Bruker, L. Cardman, J. Conway, S. Covrig Dusa, P. Degtiarenko, Y. Enomoto, S. Gessner, P. Ghoshal, S. Gopinath, J. Grames, C. Gulliford, S. Habet, G. Hays, C. Hernández-García, A. Hofler, R. Kazimi, M. Kostin, V. O. Kostroun, F. Lin, V. Lizárraga-Rubio, K. Mahler, Y. Morikawa, S. Nagaitsev, S. Ogur, G. Palacios-Serrano, N. Raut, B. Rimmer, Y. Roblin, A. Seryi, K. Smolenski, M. Stutzman, R. Suleiman, A. Sy, N. Taylor, D. Turner, A. Ushakov, C. Valerio-Lizarraga, E. Voutier, S. Wang, Y. Zhang

Mechanical & Aerospace Engineering Faculty Publications

A baseline concept for a continuous wave (CW) polarized positron injector was developed for the Continuous Electron Beam Accelerator Facility (CEBAF) at Jefferson Lab [1]. This concept is based on positron beam generation by a high current polarized electron beam (1 mA, 120 MeV, >85% polarization) irradiating a rotating water-cooled tungsten target or liquid metal target. The update on the development of the Ce⁺BAF injector concept including the polarized electron source, the development of high power targets, simulations of positron capture, the design of the transport line from the positron injector to the CEBAF North Linac and the planned experiment …

Revealing Spatiotemporal Neural Activation Patterns In Electrocorticography Recordings Of Human Speech Production By Mutual Information, Julio Kovacs, Dean Krusienski, Minu Maninder, Willy Wriggers

Mechanical & Aerospace Engineering Faculty Publications

Background

Spatiotemporal mapping of neural activity during continuous speech production has been traditionally approached using correlation coefficient (CC) analysis between cortical signals and speech recordings. A prior study employed this approach using electrocorticography (ECoG) data from participants who underwent invasive intracranial monitoring for epilepsy. However, CC cannot detect nonlinear relationships and is dominated by the correspondence between periods of silence and of non-silence.

New Method

We introduce the mutual information (MI) measure, which can capture both linear and nonlinear dependencies. We validated CC and MI on the sub-second spatiotemporal brain activity recorded during continuous speech tasks. To refine the results, …