Digital Commons Network^™

The Association Of Cognitive Function With Autonomic-Cardiovascular Reactivity To And Recovery From Stress, Sanjay Mehta

Psychology Theses & Dissertations

The contribution of stress in the development of chronic and terminal disease has garnered significant interest in contemporary research. The current study aims to look at how performance in domains of cognitive function may affect autonomic-cardiovascular reactivity and recovery to psychologically stressful tasks as such reactions, over time, may contribute to the development of cardiovascular disease.

The current study analyzed data from 209 healthy middle-age adults. This included four neuropsychological tests utilized here to represent abilities in four different cognitive domains: response inhibition, mental flexibility, verbal memory, and nonverbal memory. The participants were also introduced to three psychologically stressful tasks …

Evaluation Of Hydraulic Conductivity Of Non Aqueous Phase Liquids In Partially Saturated Soils, Chijioke Ekeleme Akamiro

Civil & Environmental Engineering Theses & Dissertations

This study seeks to investigate a problem of predicting the hydraulic conductivity of NAPLs in partially saturated soils and to relate the hydraulic conductivity to basic soil parameters that are either easy to determine or are in wide use. To evaluate hydraulic conductivity in partially saturated soils, previous researchers have focused on flow geometry, soil and chemical properties, etc. used in CHEMFLO program by Nofziger et al., (1989) and saturation equations by such authors as Van Genutchen (1980) and Brooks and Corey (1964). Among those, the soil-water characteristic curve (SWCC) is the most widely used constitutive relations for unsaturated soils …

Treatment Of Aortic Heart Valve Conduit With Glutamine And Heat Shock As A Means To Deter The Constituent Cellular Population From Becoming Apoptotic, Alyce Marie Linthurst Jones

Theses and Dissertations in Biomedical Sciences

Cryopreserved allograft heart valves represent the best solution for a patient with a failing heart valve. However, the constituent cells become apoptotic and within months of transplant the heart valve becomes acellular and the recipient's cells do not repopulate the allograft (3, 51). A strategy to prevent this situation would be to minimize or prevent apoptosis from occurring by strategically altering steps during heart valve processing. Recently it has been demonstrated that: 1) Heat shock protein 70 is a negative modulator of the apoptotic cascade; 2) Cells in culture exposed to hypothermic conditions produce heat shock protein 70 upon rewarming; …

Counselor Beliefs And Perceived Knowledge Regarding Clients With Learning Disabilities, Tamekia R. Bell

Counseling & Human Services Theses & Dissertations

Clients with learning disabilities constitute a cultural group that has not been extensively studied. The professional literature has found that counselors have reported the need for additional training in working with clients with disabilities. This study explored counselors' beliefs and perceived knowledge regarding counseling clients with learning disabilities. Participants in this study were college counselors, mental health counselors, and school counselors who were members of the following professional counseling associations: the American College Counseling Association (ACCA), the American Mental Health Counselors Association (AMCHA), and the American School Counselor Association (ASCA). These counselors were assessed to determine their perceived competency regarding …

Gender Performativity In The Community College: A Case Study Of Female Backline Classified Staff, Samantha Rose Powers

Educational Leadership & Workforce Development Theses & Dissertations

This case study explored the gendered performances of five female backline classified staff members who work in non-traditional fields within a community college. More specifically, this study defined gendered behaviors at a community college, and explored how these behaviors have affected the identities of women working in non-traditional fields at the community college. This study indicated through documents, observations, and interviews that there was mixed evidence of the degree to which gendered behavior is cultivated at a community college in Washington. Document review, interview, and observation findings showed that women at the community college reported expectations of gendered behavior, gender …

Nonosecond Pulsed Electric Field Induced Changes In Dielectric Properties Of Biological Cells, Jie Zhuang

Electrical & Computer Engineering Theses & Dissertations

Nanosecond pulsed electric field induced biological effects have been a focus of research interests since the new millennium. Promising biomedical applications, e.g. tumor treatment and wound healing, are emerging based on this principle. Although the exact mechanisms behind the nanosecond pulse-cell interactions are not completely understood yet, it is generally believed that charging along the cell membranes (including intracellular membranes) and formation of membrane pores trigger subsequent biological responses, and the number and quality of pores are responsible for the cell fate. The immediate charging response of a biological cell to a nanosecond pulsed electric field exposure relies on the …

From Homeschool To The Community College: A Multiple Case Study, Benjamin G. Kramer

Educational Leadership & Workforce Development Theses & Dissertations

The number of U.S. homeschooled students has steadily risen from the 1980's to the present, and many eventually choose to attend community colleges (Cogan, 2010; Mason, 2004; Ray, 2004a; Sorey & Duggan, 2008a). Homeschoolers who make community colleges their first structured educational setting outside the home do so for various reasons: (a) to obtain skills to prepare for a chosen career path or educational goal; (b) for economic reasons; and (c) to stay close to home (Ray, 2004b; Sorey & Duggan, 2008a). Presently, limited research explores the homeschooled population's transition during the first year of college experience. Community colleges are …

Ecology Of Tenodera Sinensis And Tenodera Angustipennis (Mantodea: Mantidae) In Eastern Virginia, Cory A. Gall

Biological Sciences Theses & Dissertations

My study, conducted on the Wildlife Refuge located on Virginia's Eastern Shore, focused on the life history, ecology, and intra- and interspecies interaction of Tenodera sinensis and T. angustipennis. Field methods included capture-mark-recapture, species, sex, and developmental life stage identification, and recorded key developmental milestones. Also, to analyze food-limiting growth, a laboratory cohort was fed ad lib, with lab and field cohorts measured bi-weekly and their mean weekly growth was compared.

When compared to a lab cohort, Tsinensis field mantises were shown not to be growth limited by the abundance of prey. In 2011, the dates of several developmental stages …

Nano- And Micro-Second Electrical Pulsing Of B16-F10 Mouse Melanoma Cells: Plasma Membrane And Sub-Cellular Organelle Changes, Yiling Chen

Theses and Dissertations in Biomedical Sciences

High electric field-treated cells are permeable to molecular dye through either opening of pores in the plasma membrane or other unknown processes which can disturb the membrane in an organized way. However, direct morphological evidence is lacking and responses of intracellular organelles are not clear. We used traditional chemical fixatives and biochemical techniques to capture cell membrane and organelle changes immediately after pulsing with high voltage electric field application. Different pulse durations, nanosecond (ns) and microsecond (µs), and field magnitudes, 60 kV/cm and 1.2 kV/cm, were applied to mouse melanoma B16-F10 cells. Two different ns durations (60 and 300 ns) …

Effects Of The Parasitic Dinoflagellate Hematodinium Sp. On Blue Crab (Callinectes Sapidus) Activity Predation And Habitat Selection, John M. Tiggelaar Ii

Biological Sciences Theses & Dissertations

The blue crab Callinectes sapidus occurs along the Atlantic and Gulf coasts of the United States, and in high salinity regions, they are subject to lethal infection by the parasitic dinoflagellate Hematodinium. In Virginia's seaside estuaries, the prevalence of Hematodinium infection of C. sapidus can sometimes exceed 50%, threatening the commercial fishery for this species. Indeed, other commercially important crustacean fisheries have approached collapse due to Hematodinium infections. Most studies of this host-parasite interaction have focused on epidemiology, host-pathogen dynamics, and pathogen transmission, and little is known about the impact of the parasite on host behavior and population dynamics. …

Electrokinetic Transport Phenomena In Nanofluidic Devices, Mingkan Zhang

Mechanical & Aerospace Engineering Theses & Dissertations

Nanofluidic devices have wide potential applications in biology, chemistry and medicine, and have been proven to be very valuable in sensing biological particles (e.g., DNA and proteins) due to their efficiency, sensitivity and portability. Electrokinetic control of ion, fluid, and particle transport by using only electric field is the most popular method employed in nanofluidic devices. A comprehensive understanding of the electrokinetic ion, fluid, and particle transport in nanofluidics is essential for developing nanofluidic devices for the detection of single molecules, such as the next generation nanopore-based DNA sequencing technology. This research explored numerical simulation of electrokinetic ion and fluid …

Modeling The Dispersion Of Eastern Oyster Larvae (Crassostrea Virginica) And Its Effects On The Movement Of Disease Resistant Genes In The Delaware Bay Estuary, Diego A. Narvaez

OES Theses and Dissertations

This study combines several models to address two primary research questions. How does the interaction of larval biology and environmental variability determine the spatial distribution of oyster larvae in Delaware Bay? What is the role of larval dispersion in the transference of disease-resistant genes? The particle-tracking module in the Regional Ocean Modeling System (ROMS) was converted into an Individual-Based model representing Eastern oyster larvae that has growth and vertical migration. Exchange of larvae between natural oyster reefs was estimated and used in an Individual-Based genetic model that simulates the genetic structure of eastern oysters. Particles were released from a number …

Hungry Heart, Valarie Clark

English Theses & Dissertations

The essays in this collection explore the resistance to and simultaneous need for human connections. In order to illustrate this concept, I use myself as an example of an individual who both longs for and despises her dependence on other people in order to support and define her. The essays are not presented in a traditional chronological format, but instead reflect the chronology of my own realization of the theme of this work. The essay titles are drawn from popular music, intended to mimic the contents of an MP3 player, which reflects the owner's personality, wants and needs. The structure …

Case Studies In Many-Body Physics, Ana Samolov

Physics Theses & Dissertations

The many-body problem refers to any physical problem made of more than two interacting particles. With increasing number of particles in a system, their coupling and entanglement becomes more complex, and there is no general analytic solution even for a three-body classical or quantum systems. However, some of the most fascinating phenomena in nature are products of collective effects. Therefore, significant efforts have been made in both experiment and theory to unravel some specific many-body problems. If we look at still unanswered physics questions we see that for most of these problems addressing the many-body interactions is a key issue. …

Health Nexus: A Serious Game Prototype For Prevention And Treatment Of Obesity And Diabetes, Joseph C. Miller

Computational Modeling & Simulation Engineering Theses & Dissertations

Electronic games are a prevalent phenomenon of American culture and entertainment. Serious games are video games that take advantage of games' intrinsic entertaining and challenging characteristics for serious purposes, such as education, training, advertisement, and political campaigns. A significant number of serious games have been developed for a variety of diverse purposes. The last few years have witnessed the inception and growth of motion sensing technologies for games, including Nintendo Wii, Sony PlayStation Move, and Microsoft Kinect. These motion sensing technologies usually require game players' physical body movement in order to perform and achieve in the games, such as playing …

Image-Guided Robotic Dental Implantation With Natural-Root-Formed Implants, Xiaoyan Sun

Electrical & Computer Engineering Theses & Dissertations

Dental implantation is now recognized as the standard of the care for tooth replacement. Although many studies show high short term survival rates greater than 95%, long term studies (> 5 years) have shown success rates as low as 41.9%. Reasons affecting the long term success rates might include surgical factors such as limited accuracy of implant placement, lack of spacing controls, and overheating during the placement.

In this dissertation, a comprehensive solution for improving the outcome of current dental implantation is presented, which includes computer-aided preoperative planning for better visualization of patient-specific information and automated robotic site-preparation for superior …

Alternative Therapy And Treatment Of Type 2 Diabetes, Carmine R. Grieco

Human Movement Studies & Special Education Theses & Dissertations

The rise in prevalence and incidence of type 2 diabetes mellitus (T2D) in the developing world continues unabated. Current treatment strategies, however, fall short of achieving optimal glycemic control. The aim of project I was to investigate the effect of an acute bout of a yogic breathing exercise on heart rate variability (HRV) in individuals with T2D. Project II was designed to assess the effectiveness of the neurohormone melatonin in lowering short- and long-term glucose levels, lipids and oxidative stress in T2D. Project III investigated the differential effects of two different styles of aerobic exercise on postprandial glycemia, mood and …

Design Of In Vivo Assays For Study Of Transport, Biocompatibility And Toxicity Of Nanoparticles, Kerry Jean Lee

Theses and Dissertations in Biomedical Sciences

This dissertation focuses on the design of new in vivo assays for study of transport, biocompatibility and toxicity of nanoparticles (NPs) in zebrafish embryos. We synthesized and purified spherical silver (Ag) NPs with diameters, ranging from 12 to 95 nm, that are stable (non-aggregated) in egg-water media. We developed new imaging approaches to characterize the sizes of single Ag NPs in zebrafish embryos at nanometer resolution by measuring their size-dependent plasmonic spectra and scattering intensity using dark-field optical microscopy and spectroscopy (DFOMS). We used single Ag NPs because they exhibit the high quantum yield (QY) of Rayleigh scattering and resist …

The Dietary Isoprenoid Perillyl Alcohol Inhibits Telomerase Activity In Prostate Cancer Cells, Tabetha Sundin

Theses and Dissertations in Biomedical Sciences

This is the first evidence that a plant-derived compound–perillyl alcohol regulates telomerase activity via the mammalian target of rapamycin (mTOR) pathway in prostate cancer cells. Telomerase–the enzyme responsible for immortalizing cells through telomeric repeats addition–is de-repressed early in an aspiring cancer cell. We hypothesized that perillyl alcohol regulates hTERT (human telomerase reverse transcriptase) at the translational and post-translational levels via its effects on the mTOR pathway. A rapid suppression of telomerase activity was detected in prostate cancer cell lines (PC-3 and DU145) in response to biologically-relevant concentrations and short incubations of perillyl alcohol or the mTOR inhibitor—rapamycin.

Western blot analysis …

Graduate News, Office Of Graduate Studies, Old Dominion University

Graduate News

March 2012 issue of Graduate News from the Office of Graduate Studies (now, ODU Graduate School).

Regulation Of The Vapbc-1 Toxin-Antitoxin Locus In Nontypeable Haemophilus Influenzae, Susan D. Cline, Sehresh Saleem, Dayle A. Daines

Biological Sciences Faculty Publications

Nontypeable Haemophilus influenzae (NTHi) are human-adapted commensal bacteria that can cause a number of chronic mucosal infections, including otitis media and bronchitis. One way for these organisms to survive antibiotic therapy and cause recurrent disease is to stop replicating, as most antimicrobials target essential biosynthetic pathways. Toxin-antitoxin (TA) gene pairs have been shown to facilitate entry into a reversible bacteriostatic state. Characteristically, these operons encode a protein toxin and an antitoxin that associate following translation to form a nontoxic complex, which then binds to and regulates the cognate TA promoter. Under stressful conditions, the labile antitoxin is degraded and the …

Anthropogenic Climate Change And Allergic Diseases, James Blando, Leonard Bielory, Viann Nguyen, Rafael Diaz, Hueiwang Anna Jeng

Community & Environmental Health Faculty Publications

Climate change is expected to have an impact on various aspects of health, including mucosal areas involved in allergic inflammatory disorders that include asthma, allergic rhinitis, allergic conjunctivitis and anaphylaxis. The evidence that links climate change to the exacerbation and the development of allergic disease is increasing and appears to be linked to changes in pollen seasons (duration, onset and intensity) and changes in allergen content of plants and their pollen as it relates to increased sensitization, allergenicity and exacerbations of allergic airway disease. This has significant implications for air quality and for the global food supply.

A Retrospective Analysis Of Sustainable Oyster Harvest From The Louisiana State Primary Seed Grounds, 1999-2010: A Shell-Neutral Modeling Approach, Thomas M. Soniat, Mahdi Abdelguerfi, Eric N. Powell, John M. Klinck, Eileen E. Hofmann, Shengru Tu, Nathan Cooper, Janak Dahal, John Finigan, Benjamin S. Eberline, Jerome F. La Peyre, Megan K. La Peyre, Keith B. Ibos, Brian Lezina, Patrick Banks

CCPO Publications

No abstract provided.

Graduate News, Office Of Graduate Studies, Old Dominion University

Graduate News

February 2012 issue of Graduate News from the Office of Graduate Studies (now, ODU Graduate School).

Quality Of Life Of Families With Children Who Have Severe Developmental Disabilities: A Comparison Based On Child Residence, Joni Taylor Mcfelea, Sharon Raver

Communication Disorders & Special Education Faculty Publications

This study measured the quality of life of two groups of families with children who had severe developmental disabilities-families whose child lived at home and families whose child lived in a residential facility. Participants were 54 primary caregivers of children who had severe intellectual disabilities and who lacked the ability to both ambulate without assistance and communicate conversationally. Participants completed the "Family Quality of Life Scale" (Hoffman, Marquis, Poston, Summers, & Turnbull, 2006). Analyses revealed that both groups rated their family quality of life (FQOL) as exemplary. FQOL was higher in the family home group than in the residential facility …

The Golems Take New York: The Resurgence Of The Golem In The Work Of Cynthia Ozick And Thane Rosenbaum, Peter Schulman

World Languages and Cultures Faculty Publications

The late twentieth and early twenty first centuries have seen a resurgence of the golem in several major American novels. What factors might lead to such a re-imagining of the golem in American fiction? Cynthia Ozick's The Puttermesser Papers (1997) and Thane Rosenbaum's The Golems of Gotham (2002) re-invent golems no longer anchored in vengeance but in healing, as vehicles for the kabbalistic notion of Tikkun Olam ("repairing the world"). Ozick creates the first female golem to help the lonely protagonist become a reformist mayor; in The Golems of Gotham, the golem is transformed into a team of literary …

Novel Report Of Expression And Function Of Cd97 In Malignant Gliomas: Correlation With Wilms Tumor 1 Expression And Glioma Cell Invasiveness Laboratory Investigation, Archana Chidambaram, Helen L. Fillmore, Timothy E. Van Meter, Catherine I. Dumur, William C. Broaddus

Division of Research and Economic Development Faculty & Staff Publications

Object. The Wilms tumor 1 (WT1) protein—a developmentally regulated transcription factor—is aberrantly expressed in gliomas and promotes their malignant phenotype. However, little is known about the molecular allies that help it mediate its oncogenic functions in glioma cells.

Methods. The authors used short interfering RNA (siRNA) to suppress WT1 expression in glioblastoma (GBM) cells and evaluated the effect of this on GBM cell invasiveness. Gene expression analysis was then used to identify the candidate genes that were altered as a result of WT1 silencing. One candidate target, CD97, was then selected for further investigation into its role by suppressing …

The Struggle For 'Appropriateness'-New Sources Of (Techno-) Stress, Stefan Schellhammer, Russell Haines, Stefan Klein

Information Technology & Decision Sciences Faculty Publications

Information and communication technologies are employed in every aspect of contemporary life. Facilitated by ICT, many innovations in the organization of work have taken hold. The effects of these developments on the quality of life are disputed. By referring to the phenomenon of ‘technostress,’ scholars’ caution against potentially harmful effects of ICT on workers’ health. This relatively new line of research roots the sources of stress for the individual in features of ICT. The present paper is motivated by the observation that ICT is also rooted in social relations. The way it is used is heavily influenced by social norms …

An Introduction To Prayer Research In Communication: Functions, Contexts, And Possibilities, E. James Baesler

Communication & Theatre Arts Faculty Publications

No abstract provided.

Cell Permeabilization And Inhibition Of Voltage-Gated Ca²+ And Na+ Channel Currents By Nanosecond Pulsed Electric Fields, Vasyl Nesin, Angela M. Bowman, Shu Xiao, Andrei G. Pakhomov

Bioelectrics Publications

Previous studies have found that nanosecond pulsed electric field (nsPEF) exposure causes long-term permeabilization of the cell plasma membrane. In this study, we utilized the whole-cell patch-clamp method to study the nsPEF effect on currents of voltage-gated (VG) Ca²⁺ and Na⁺ channels (I_Ca and I_Na) in cultured GH3 and NG108 cells. We found that a single 300 or 600 ns pulse at or above 1.5-2 kV/cm caused prolonged inhibition of I_Ca and I_Na. Concurrently, nsPEF increased a non-inactivating leak current (I_leak), presumably due to the formation of nanoelectropores or larger …