Digital Commons Network^™

Pthr1/Sox9 And Idh1/Idh2 Relative Expression In Primary Chondrocyte And Chondrosarcoma Cells Under The Synergistic Influence Of Inducible Hypoxia And Extracellular Acidosis, Kostika Vangjeli

Biological Sciences Theses & Dissertations

Cartilage cells (Chondrocytes) grow in rather unique environmental conditions in the human body. Cartilage is avascular tissue and lacks innervation. Its main source of nutrients is derived from the synovial fluid and/or perichondrium. Consequently, these cells must survive and thrive under hypoxic and acidic stressors. Published data suggests that there are a multitude of genes affected from either one of these two stressors or both. However, these factors are frequently overlooked in cartilage research, and results are reported in either normoxia/pH=7.0 conditions, or they only account for one of the conditions. The scope of this study is to examine how …

Deep Cellular Recurrent Neural Architecture For Efficient Multidimensional Time-Series Data Processing, Lasitha S. Vidyaratne

Electrical & Computer Engineering Theses & Dissertations

Efficient processing of time series data is a fundamental yet challenging problem in pattern recognition. Though recent developments in machine learning and deep learning have enabled remarkable improvements in processing large scale datasets in many application domains, most are designed and regulated to handle inputs that are static in time. Many real-world data, such as in biomedical, surveillance and security, financial, manufacturing and engineering applications, are rarely static in time, and demand models able to recognize patterns in both space and time. Current machine learning (ML) and deep learning (DL) models adapted for time series processing tend to grow in …

Longitudinal Brain Tumor Tracking, Tumor Grading, And Patient Survival Prediction Using Mri, Linmin Pei

Electrical & Computer Engineering Theses & Dissertations

This work aims to develop novel methods for brain tumor classification, longitudinal brain tumor tracking, and patient survival prediction. Consequently, this dissertation proposes three tasks. First, we develop a framework for brain tumor segmentation prediction in longitudinal multimodal magnetic resonance imaging (mMRI) scans, comprising two methods: feature fusion and joint label fusion (JLF). The first method fuses stochastic multi-resolution texture features with tumor cell density features, in order to obtain tumor segmentation predictions in follow-up scans from a baseline pre-operative timepoint. The second method utilizes JLF to combine segmentation labels obtained from (i) the stochastic texture feature-based and Random Forest …

Diet Analysis Of Stranded Bottlenose Dolphins (Tursiops Truncatus) In Virginia, Kristen Marie Volker

Biological Sciences Theses & Dissertations

This study describes the diet of bottlenose dolphins (Tursiops truncatus) stranded in Virginia via stomach content analysis and considers factors such as proportion of numerical abundance and reconstructed mass, frequency of occurrence, average reconstructed prey size, prey diversity and quantity, and otolith degradation code. Fish size was estimated via regression equations established from local fish collected during the study that derive wet weight directly from otolith length or width. Squid size is estimated from previously published equations. Soniferous fishes dominated the diet, especially Atlantic croaker, spot, and seatrout spp., adding evidence to the theory that bottlenose dolphins passively …

Terrorists, Zombies, And Robots: The Political Unconscious, Thematics, And Affectual Structures Of The Post-9/11 American Fear Narrative, Nathanael J. Cloyd

English Theses & Dissertations

This dissertation examines the post-9/11 American fear narrative across media and genre. First, it proposes the concepts of the fear narrative, the primary fear theme, and the secondary fear theme. Second, it proposes that the fear narrative has a long tradition in American culture, in which its themes have adapted and evolved in historically sedimented layers of development. Third, it proposes that American fear themes change depending on its historical context of production, its cultural regime, its genre, and the form of media in which it is expressed. To help uncover the political unconsciousness of the American fear narrative, it …

Effects Of Transparency And Haze On Trust And Performance During A Full Motion Video Analysis Task, Sarah C. Leibner

Psychology Theses & Dissertations

Automation is pervasive across all task domains, but its adoption poses unique challenges within the intelligence, surveillance, and reconnaissance (ISR) domain. When users are unable to establish optimal levels of trust in the automation, task accuracy, speed, and automation usage suffer (Chung & Wark, 2016). Degraded visual environments (DVEs) are a particular problem in ISR; however, their specific effects on trust and task performance are still open to investigation (Narayanaswami, Gandhe, & Mehra, 2010). Research suggests that transparency of automation is necessary for users to accurately calibrate trust levels (Lyons et al., 2017). Chen et al. (2014) proposed three levels …

What We Do Not Perceive When We Perceive It, Hannah Jane Trammell

English Theses & Dissertations

The thesis herein attempts to traverse, overcome, and, ultimately subsume back into the conventions of such genres as science-fiction, fabulism, surrealism, romance, horror, and speculative fiction. The primary tool used for this purpose is a great bag of hot, sparking meat caught between two ears and a thick skull. A few notebooks, pens, and a laptop might also have helped in this pursuit. The stories and poems contained herein are works of fiction inspired by non-fictional systems of feeling. Using all the tools given to me by my professors and the craft and theory books I read during my coursework …

The Influence Of Mating Motives On Reliance On Form Versus Function In Product Choice, Seyed Hamid Abbassi Hosseini

Theses and Dissertations in Business Administration

Through five experiments, this research examined and supported the central hypothesis that a casual mating motive promotes higher reliance on form in product evaluation and choice, whereas a committed mating motive promotes higher reliance on function. Particularly, compared to a committed mating motive, a casual mating motive was associated with the relative preference for product options superior in form attributes as opposed to options superior in function attributes (Study 1, Study 2, and Study 4). This research applied three different operationalizations of mating motives. In studies 1 and 5, contextual priming was used. Studies 2 and 3 employed chronic mating …

A Critical Review Of The 15N2 Tracer Method To Measure Diazotrophic Production In Pelagic Ecosystems, Angelicque E. White, Julie Granger, Corday Seldon, Mary R. Gradoville, Lindsey Potts, Annie Bourbonnais, Robinson W. Fulweiler, Angela N. Knapp, Wiebke Mohr, Pia H. Moisander, Craig R. Tobias, Mathieu Caffin, Samuel T. Wilson, Mar Benavides, Sophie Bonnet, Margaret R. Mulholland, Bonnie X. Chang

OES Faculty Publications

Dinitrogen (N₂) fixation is an important source of biologically reactive nitrogen (N) to the global ocean. The magnitude of this flux, however, remains uncertain, in part because N₂ fixation rates have been estimated following divergent protocols and because associated levels of uncertainty are seldom reported—confounding comparison and extrapolation of rate measurements. A growing number of reports of relatively low but potentially significant rates of N₂ fixation in regions such as oxygen minimum zones, the mesopelagic water column of the tropical and subtropical oceans, and polar waters further highlights the need for standardized methodological protocols for measurements …

Assessing Microplastic Pollution In Four Mile Run, An Urban Stream In Northern Virginia, Kurt Moser, Tessa Naughton-Rockwell, Louisa Wang, Ethan Litmans, Amanda Manoogian

Virginia Journal of Science

Microplastics are pollutants of concern in waterways and oceans for their persistence and impact on aquatic life and food webs. This study demonstrates a low-cost land-based sampling method to assess the extent of microplastic pollution found in Four Mile Run, an urban stream in Northern Virginia. Microplastic particle counts in environmental and treated wastewater ranged from 0.01-0.24 particles L^-1 (mean 0.08 particles L^-1) and from 2 to 446 µg L^-1 (mean 70 µg L^-1), with fibers found to be the most common microplastic category. Treated wastewater effluent was found to be a significant source …

A Feel For The Game: Ai, Computer Games And Perceiving Perception, Marc A. Ouellette, Steven Conway

English Faculty Publications

I walk into the room and the smell of burning wood hits me immediately. The warmth from the fireplace grows as I step nearer to it. The fire needs to heat the little cottage through the night so I add a log to the fire. There are a few sparks and embers. I throw a bigger log onto the fire and it drops with a thud. Again, there are barely any sparks or embers. The heat and the smell stay the same. They don’t change and I do not become habituated to it. Rather, they are just a steady stream, …

Diatom Community Composition Shifts Driven By Coherent Cyclonic Mesoscale Eddies In The California Current System, Zuzanna Maria Abdala

OES Theses and Dissertations

The California Current System (CCS) is characterized by an equatorward flowing eastern boundary current, as well as seasonal wind-driven coastal upwelling which supplies nutrient-rich waters to the surface and drives high coastal productivity. Cyclonic mesoscale eddies form off the coast in the CCS where they trap the highly productive upwelled coastal waters, along with their resident planktonic communities, and transport them offshore into the more oligotrophic California Current waters. The interaction between waters within and outside of the eddies is limited, and so the eddies act as natural mesocosms, where the resident phytoplankton population undergo ecological succession as the eddy …

Network Approaches To Elucidate The Determinants Of Protein Topology And Stability, Zeinab Haratipour

Chemistry & Biochemistry Theses & Dissertations

Predicting three-dimensional structures of proteins from sequence information alone, remains one of the most profoundly challenging and intensely studied problems in basic science. It has uniquely garnered the interdisciplinary efforts of biologists, biochemists, computer scientists, mathematicians and physicists. The advancement of computational methods to study fundamental features of proteins also enables insights that are either difficult to explore experimentally or complimentary to further interpret experimental data. In the present research and through the combined development and application of molecular dynamics and network science approaches we aimed to elucidate the role of geographically important amino acids and evolutionarily conserved long-range interactions …

Olfactory Behavioral Responses Of Mosquito Vectors To Select Attractants And Floral Scents As Related To Circadian Rhythms And Photoperiod Regimes, Bernadette A. Ferraro

Biomedical Sciences Theses & Dissertations

This dissertation discusses mosquito behavioral activities involving circadian rhythms defined as insect sensitivity to select of chemical volatiles that vary throughout the 24-hour day. Circannual rhythms occur over seasons varying in photoperiod, defined as the seasonal cycle of light and darkness. These cycles can be endogenously controlled by circadian clocks. The impetus for this research was initiated when reading about the neglected temporal dimension in the context of insect chemical ecology, including insect olfaction. It was proposed that sensitivity to odors does not change in general, but specific sensitivities could vary according to time of day. Chemical scents emitted by …

Lignin: A Likely Precursor Of A Significant Fraction Of Humic Substances Via Oxidative Transformations, Seyyedhadi Khatami

Chemistry & Biochemistry Theses & Dissertations

Lignin is a major component of decaying terrestrial vegetation in soils and has been arguably reported to contribute substantially to the formation of soil carbon humus, and natural dissolved organic matter (DOM). To better understand the process by which this humification occurs, lignin and lignin-derived monomers were subjected to both biotic and abiotic oxidation processes. Two well-known oxidative transformation strategies were employed. The first involved the fungal degradation of brown-rot degraded wood subjected to a white-rot fungus (Phanerochaete chrysosporium) whose enzymes are particularly effective in lignin degradation via enzymatic oxidation. This enzymatic attack was monitored by ultrahigh resolution …

Mental Health Counselors' Perceptions On Preparedness In Integrated Behavioral Healthcare In Underserved Areas, Kyulee Park

Counseling & Human Services Theses & Dissertations

Integration of behavioral and primary healthcare (IBH) has been increasingly suggested as a model approach in serving historically marginalized populations, including rural, Healthcare Provider Shortage (HPSA), and Medically Underserved (MUA) communities (Coleman & Patrick, 1976; Wong et al., 2019). However, there is no evidence-based practices in interprofessional education and training for professional mental health counselors to serve as competent practitioners in integrated behavioral healthcare. This study examined the gap in interprofessional and counselor education literature by identifying the lived experiences and perceptions of mental health professionals in integrated settings and assessed the need areas in current counselor education. A phenomenological …

Flexible Electrochemical Lactate Sensor, Peyton Miesse

Biomedical Engineering Theses & Dissertations

Lactic acid is a vital indicator for shock, trauma, stress, and exercise intolerance. It is a key biomarker for increases in stress levels and is the primary metabolically produced acid responsible for tissue acidosis that can lead to muscle fatigue and weakness. During intensive exercise, the muscles go through anerobic metabolism to produce energy. This leads to decreases in the blood flow of nutrients and oxygen to the muscles and increases in lactate production, which in turn cause lactic acidosis. Currently, changes in blood lactate concentrations are monitored by sensors that can be invasive via blood or wearable based sensors …

The Effects Of Hackberry Psyllids On Refueling Migratory Songbirds And Autumnal Seed Rain, Chance H. Hines

Biological Sciences Theses & Dissertations

Hackberry psyllids (Pachypsylla sp) are a galling insect native to North America’s hackberry trees (Celtis sp). Hackberry leaf-galling psyllids are ephemerally abundant during autumn, a period of time when migratory songbirds are traveling from their breeding areas in temperate North America south to their winter ranges. These migrations are energetically taxing and many songbirds fuel their journey with resources like insects and fruits. I captured birds with mist nets, observed foraging behaviors, and captured avian-dispersed fleshy fruit seeds (hereafter, seed rain) rain during the autumn of 2016 and 2017 to determine how hackberry psyllids, an ephemerally …

The Impacts Of Surface Gravity Waves On Buoyant Plume Dilution, Bruce William Husselbee

Civil & Environmental Engineering Theses & Dissertations

A common practice in coastal areas is to collect, treat and discharge fluids including treated wastewater, stormwater or power plant effluent to areas of lesser impact. The discharge of these fluids, conveyed through pipelines into coastal areas, continues to be an important human health and environmental concern. The fluid discharged from these pipelines is often buoyant which allows for dilution and dispersion into these ambient waters.

Initial dilution, defined as the maximum concentration of a discharged fluid at the maximum rise in height within a buoyant plume, is critical in the consideration of the environmental impacts of a discharge into …

Leveraging Maternal Rhetoric, Space, And Experience: La Leche League's Emergence As A Counterpublic, Jenny Lynn Moore

English Theses & Dissertations

For over six decades, the international, mother-to-mother breastfeeding support organization La Leche League (LLL) has been helping women breastfeed successfully. LLL was formed at a time when the dominant ideology of scientific motherhood framed mothers as obedient adherents to physicians’ strict guidelines, which encouraged bottle-feeding and discouraged close mother-child bonds. LLL has been credited with challenging scientific motherhood, transforming medical discourse and practices surrounding infant feeding, and prompting the medical professional to accept mothers’ active involvement in decision-making; yet, paradoxically, it has also constrained mothers by reducing women to their maternal biology, discouraging mothers from participating in the public sphere, …

Impedance Analysis Of Tissues In Nspef Treatment For Cancer Therapy, Edwin Ayobami Oshin

Biomedical Engineering Theses & Dissertations

Nanosecond pulsed electric field (nsPEF) for cancer therapy is characterized by applications of high voltage pulses with low pulsed energy to induce non-thermal effects on tissues such as tumor ablation. It nonthermally treats tissues via electroporation. Electroporation is the increase in permeabilization of a cell membrane due to the application of high pulsed electric field. The objective of this study was to investigate the effect of nsPEF on tissue by monitoring the tissue’s impedance in real-time. Potato slices (both untreated and electroporated), and tumors extracted from female BALBc mice were studied. 100ns, 1-10kV pulses were applied to the tissues using …

Effects Of Religion On Crime In Hampton Roads, Alaina Yvonne Bierdz

Sociology & Criminal Justice Theses & Dissertations

The influence of religion in society has been debated for hundreds of years. Renowned scholars like Max Weber and Émile Durkheim formed frameworks in which to study the relationship between religion and crime. The frameworks are based on the idea that religion promotes desirable behavior in society, while also controlling undesirable behavior. Although religion can be studied across many disciplines, this report examines the relationship between religion and crime. More specifically, the impact of religion on crime in the Hampton Roads area in Virginia. It has been thought that religiosity decreases crime. Using social bond theory as the theoretical perspective, …

Diagnostic Studies Of Non-Thermal Atmospheric Pressure Nanosecond Plasma Jets, Shutong Song

Electrical & Computer Engineering Theses & Dissertations

Non-thermal atmospheric pressure plasma jets attract a lot of attentions due to its growing interest in plasma medicine. In this study, reactive species (e.g. excited He, O, OH) in a helium single-electrode non-thermal atmospheric pressure nanosecond plasma jet (APNPJ) driven by a nanosecond pulsed power supply have been studied via electrical measurements (e.g. voltage, current) and optical emission spectroscopy. It is shown that the gas temperature of the APNPJs remained near 300±50 K by fitting N₂(C-B) second positive system and OH(A-X) emission spectrum. Higher excited N₂+ (by a factor of 1.3) but less excited N_{2 …}

Marine Carbonyl Sulfide (Ocs) And Carbon Disulfide (Cs2): A Compilation Of Measurements In Seawater And The Marine Boundary Layer, Sinikka T. Lennartz, Christa A. Marandino, Marc Von Hobe, Meinrat O. Andreae, Kazushi Aranami, Elliot Atlas, Max Berkelhammer, Heinz Bingemer, Dennis Booge, Gregory A. Cutter, Pau Cortes, Stefanie Kremser, Cliff S. Law, Andrew Marriner, Rafel Simó, Birgit Quack, Günther Uher, Huixiang Xie, Xiaobin Xu

OES Faculty Publications

Carbonyl sulfide (OCS) and carbon disulfide (CS₂) are volatile sulfur gases that are naturally formed in seawater and exchanged with the atmosphere. OCS is the most abundant sulfur gas in the atmosphere, and CS₂ is its most important precursor. They have attracted increased interest due to their direct (OCS) or indirect (CS₂ via oxidation to OCS) contribution to the stratospheric sulfate aerosol layer. Furthermore, OCS serves as a proxy to constrain terrestrial CO₂uptake by vegetation. Oceanic emissions of both gases contribute a major part to their atmospheric concentration. Here we present a database of …

Biomimetic Metal-Organic Nanoparticles Prepared With A 3d-Printed Microfluidic Device As A Novel Formulation For Disulfiram-Based Therapy Against Breast Cancer, Ya Chang, Jizong Jiang, Wu Chen, Wen Yang, Lili Chen, Pengyu Chen, Jianzhong Shen, Shizhi Qian, Teng Zhou, Linfeng Wu, Liang Hong, Yongzhuo Huang, Feng Li

Mechanical & Aerospace Engineering Faculty Publications

Disulfiram (DSF) is currently tested in several clinical trials for cancer treatment in combination with cop-per (Cu) ions. Usually, DSF and Cu are administered in two separate formulations. In the body, DSF andCu ions form diethyldithiocarbamate copper complex [Cu(DDC)₂] which has potent antitumor activities.However, the “two formulation” approach often achieved low Cu(DDC)₂ concentration at tumor regions and resulted in compromised anticancer efficacy. Therefore, preformed Cu(DDC)₂ complex administered in a single formulation will have better anticancer efficacy. However, the poor aqueous solubility of Cu(DDC)₂ is a significant challenge for its clinical use. In this work, a …

A Halogen Bonding Perspective On Iodothyronine Deiodinase Activity, Eric S. Marsan, Craig A. Bayse

Chemistry & Biochemistry Faculty Publications

Iodothyronine deiodinases (Dios) are involved in the regioselective removal of iodine from thyroid hormones (THs). Deiodination is essential to maintain TH homeostasis, and disruption can have detrimental effects. Halogen bonding (XB) to the selenium of the selenocysteine (Sec) residue in the Dio active site has been proposed to contribute to the mechanism for iodine removal. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are known disruptors of various pathways of the endocrine system. Experimental evidence shows PBDEs and their hydroxylated metabolites (OH-BDEs) can inhibit Dio, while data regarding PCB inhibition are limited. These xenobiotics could inhibit Dio activity by competitively …

Cold Plasma In Medicine And Healthcare: The New Frontier In Low Temperature Plasma Applications, Mounir Laroussi

Electrical & Computer Engineering Faculty Publications

Low temperature plasmas that can be generated at atmospheric pressure and at temperatures below 40°C have in the past couple of decades opened up a new frontier in plasma applications: biomedical applications. These plasma sources produce agents, such as reactive species (radicals and non-radicals), charged particles, photons, and electric fields, which have impactful biological effects. Investigators have been busy elucidating the physical and biochemical mechanisms whereby low temperature plasma affects biological cells on macroscopic and microscopic scales. A thorough understanding of these mechanisms is bound to lead to the development of novel plasma-based medical therapies. This mini review introduces the …

2019 Undergraduate Research Symposium: Full Program, Honors College, Old Dominion University

Undergraduate Research Symposium

Full program with schedule and abstracts for the 2019 Undergraduate Research Symposium.

2018 Undergraduate Research Symposium: Full Program, Honors College, Old Dominion University

Undergraduate Research Symposium

Full program with schedule and abstracts for the 2018 Undergraduate Research Symposium.

2020 Undergraduate Research Symposium: Full Program, Honors College, Old Dominion University

Undergraduate Research Symposium

Full program with schedule and abstracts for the 2020 Undergraduate Research Symposium.