Digital Commons Network^™

Reproductive Outcomes In A Mouse Model Of Alzheimer's Disease, Melanie Mendonca, Esperanza Barrios, Chana Vogel, Victoria Pulido-Correa

Undergraduate Student Symposium

Alzheimer’s disease (AD) is a devastating neurodegenerative disease lacking effective treatment. Despite women having 2x greater risk for developing AD, few studies have investigated the sex-specific factors that influence AD risk. Reports show a difference in the risk and progression of AD in parents and nonparents, suggesting motherhood may mitigate the risk and impacts of AD, but alternative explanations could play a role. For example, healthier and wealthier people may have more reproductive opportunities and less disease risk. Moreover, genes that alter disease risk could also modify fertility/fecundity, such as APOE4, a gene that increases both AD risk and fertility. …

Size At Sexual Maturity Of The Bluntnose Stingray (Hypanus Say) And The Atlantic Stingray (Hypanus Sabinus) From The Indian River Lagoon, Florida, Katelyn Mckimmy, Jordan Zulli, Jessica Schieber

Undergraduate Student Symposium

Bluntnose (Hypanus say) and Atlantic (Hypanus sabinus) stingrays in Family Dasyatidae are benthic species found in abundant numbers in the Indian River Lagoon, a major estuarine ecosystem along the Atlantic coast of Florida. Although the Indian River Lagoon ecosystem is experiencing increasing anthropogenic pressures and effects on local habitats from climate change, data specifically regarding H. say and H. sabinus life histories are currently lacking. Using specimens collected monthly from a collaboration with the Florida Fish and Wildlife Conservation Commission, average size at sexual maturity was assessed for both sexes of H. say (n = 126) …

The Effects Of Turkesterone On Mood And Sexual Functioning, Alexandra Jimenez Gonzalez

Undergraduate Student Symposium

Introduction: Turkesterone, an ecdysteroid found in the ajuga turkestanica plant, is a naturally occurring compound used historically in Central Asia and India to treat a multitude of health conditions. Turkesterone may hold properties that could improve physical and mental performance. This study aimed to determine the impact of four-week Turkesterone supplementation on mood and sexual function.

Methods: This randomized study included 30 active participants (14 males, 16 females). The placebo group received rice flour; the treatment group received Turkesterone (500mg/day). The participants were instructed to take their respective supplements for 28 days without altering their daily activities, diet, or exercise …

Synergistic Anticancer Effects Of Jq-1 And Doxorubicin Via Myc Downregulation And Apoptosis Induction, Abby Morrill, Srika Saai Talanki, Sneha Subhash, Sabrin Safar, Maria Moreno Hollweg, Kyuree Chang, María Guillén-Méndez, Swara Chindahade

Undergraduate Student Symposium

Aggressive cancers are particularly challenging due to their rapid growth, ability to adapt, and resistance to single therapies. Combination therapies or a multipronged approach can increase tumor cell killing and limit the development of drug resistance. The potential of combining conventional chemotherapy with targeted therapies was investigated. To determine the best drug combinations, viability assays using an 8 x 8 dose response matrix format (checkerboard) with small-step serial dilutions of cytotoxic and targeted drugs was performed. The resulting viability data, as determined by MTS assay, was analyzed using the web application SynergyFinder. The results indicated that the combined drug treatment …

The Impact Of A Healthy Intervention And Psychotherapy On Cardiovascular Disease In Ptsd Individuals, Radiah Patwary

Undergraduate Student Symposium

Significant research indicates a relationship between post-traumatic stress disorder (PTSD) and cardiovascular disease (CVD) risk. Those affected with PTSD have been found to show higher patterns of CVD risk earlier in life compared to the general population. Interventions need to be developed to reduce the risk of CVD in PTSD individuals. Although there has been research regarding the elevated CVD risk in PTSD, little research has been done addressing CVD risk reduction in the same population. To tackle this issue, adjunctive treatments, such as health behavior interventions, may be required in addition to traditional psychotherapy for PTSD to reduce overall …

The Role Of Attachment And Self-Esteem In Identity Development Among Emerging Adults, Akhila Nalluri, Preetham Gopu, Charvi Thumati

Undergraduate Student Symposium

Emerging adulthood, a transitive period between 18 and 25 years, is widely considered a period marked by change, experimentation, exploration, and development. Attachment theory postulates that relationships between children and their caregivers are crucial for the organization/representation of the self. Extant research indicates that secure parent-child-relationships and identity-development co-exist during emerging-adulthood. Self-esteem has also been associated with secure identity-formation. While there is considerable research on the associations between parent-child relationships and identity formation, as well as self-esteem and identity-formation, relatively little is known about the combined effects of parent-child relationships and self-esteem on identity-development during emerging-adulthood.

The present study explores …

Targeting The Renin-Angiotensin System For The Treatment Of Cerebral Amyloid Angiopathy, Ariana Hernandez, Chana Vogel, Victoria Pulido-Correa, Natalia Noto, Yazmin Restrepo, Shay Moen, Julianna Bonetti

Undergraduate Student Symposium

Cerebral amyloid angiopathy (CAA), the accumulation of amyloid proteins in the cerebral vasculature, can increase the risk of stroke, vascular cognitive impairment, and dementia. CAA is highly comorbid with Alzheimer’s disease and contributes to Alzheimer’s pathology by affecting the clearance of amyloid from the brain. Epidemiological studies suggest that certain renin-angiotensin system-targeting drugs, commonly used for the treatment of hypertension, decrease the risk of dementia. This study assesses whether two FDA-approved RAS-targeting drugs: telmisartan [a brain-penetrant angiotensin receptor blocker (ARB)], and lisinopril [a brain-penetrant angiotensin-converting enzyme (ACE) inhibitor]; can be repurposed to mitigate CAA, associated neuropathologies, and cognitive decline in …

Exploring Dual-Language Testing And Verbal Ability Performance In Non-Native English Speakers, Jaylyn Marte, Andrea Fajardo Aguilar

Undergraduate Student Symposium

Research suggests that Spanish/English bilinguals do not perform as well as English-speaking monolinguals on tests of verbal ability. Even when born, raised, and educated in the US, Spanish/English bilinguals do not perform as well as monolinguals. The current study was designed to investigate whether: (1) Spanish/English bilingual college students improve their performance on verbal ability tests when given the opportunity to respond in either of their two languages relative to responding only in English; and (2) do they perform similar to monolinguals under dual language testing. A previous study from our laboratory used the Bilingual Verbal Ability Test (BVAT) which …

Identifying Biomarkers Indicative Of Active And Passive Exposure To Electronic Cigarette Aerosols, Armaan Makwana, Om Patel, Chelsea Nguyen

Undergraduate Student Symposium

Electronic cigarettes (e-cigarettes) have grown in popularity as they are portrayed as a healthier alternative to conventional cigarettes. However, recent studies revealed the presence of toxic chemicals in e-cigarettes liquids and their aerosols. It is expected that active e-cigarette users are being exposed to these chemicals, however, little is known about secondhand exposure to non-users. In this work, we analyzed biological specimens from active users and non-users, especially those who live or work with an active user, to determine whether their samples contain volatile organic compounds (VOCs) indicative of exposure to e-cigarette aerosols. Headspace solid-phase microextraction (HS-SPME) with gas chromatography-mass …

Impact Of Hnrnp1/2 Modulation (Or Downregulation) On Alternative Exon Splicing In Wm266-4 Melanoma Cells, Chloe Brooks-Noriega

Undergraduate Student Symposium

This study aims to conduct an unbiased analysis of the modulation of heterogeneous nuclear ribonucleoproteins H1 and H2 (hnRNPH1/H2) on overall melanoma RNA expression in vitro. At present it is estimated that approximately 57,000 melanoma deaths occur worldwide each year. This prevalence, in conjunction with melanoma molecular heterogeneity and resulting difficulty in treatment, means that there is always a need for new treatment methods. A compound discovered in the lab, named 2155-14, has demonstrated selectivity in targeting melanoma cells by binding to hnRNPH1 and hnRNPH2, two closely related proteins that participate in RNA splicing. We performed Illumina RNA sequencing …

Improving Enzyme Activity And Stability Using Polymer Grafting, Chris Cherian, Victor Lu, Chanakya Prasad Valmiki, Stebin Chanasseril

Undergraduate Student Symposium

Enzymes are ideal chemical catalysts because of their selectivity and specificity. However, the use of enzymes in synthesizing new products is limited by their activity loss due to protein denaturation in a reaction mixture. The purpose of this study is to stabilize model enzymes by attaching them to polymers. Asparaginase, glucose-6-phosphate dehydrogenase and b-galactosidase are chosen for this study. These enzymes are selected because of their important functions in cancer treatment, measuring glucose levels in clinical samples, or making lactose-free dairy products. The free amine groups of N-terminus and lysine residues were chemically modified to attach these enzymes to the …

Investigating The Presence And Persistent Organic Pollutants (Pop) In Alaskan Oncorhynchus Keta And Oncorhynchus Kisutch, Christopher Joseph, Srujan Miryala, Alisa Shapsis

Undergraduate Student Symposium

Persistent organic pollutants (POPs) are chemical substances that resist degradation and have a range of adverse effects that have been linked to detrimental health issues in both humans and wildlife. Their introduction into the environment stems from the extensive usage of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) for industrial and agricultural purposes. While their use was banned during the Stockholm Convention in 2004, their presence persists. Since 209 different congeners exist for both PCBs and PBDEs, the primary aim of this project is to identify the types and concentrations of POPs present in Chum salmon (Oncorhynchus keta …

Investigating The Role Of Dnmt Inhibitor Cm-272 Through P21-Mediated Apoptosis In Sk-N-Sh Neuroblastoma Cells, Sruthika Talanki, Sneha Subhash

Undergraduate Student Symposium

Neuroblastoma is a pediatric malignancy originating from neural crest cells, which can manifest the disease anywhere along the sympathetic nervous system. Evidence suggests that epigenetic modifications may trigger cell cycle arrest and induce apoptosis, providing a potential therapeutic avenue for such cancers.

This study investigates whether CM-272, a DNMT-1 inhibitor, promotes histone acetylation and upregulates p21 through a p53-independent pathway, ultimately triggering cell cycle arrest and apoptosis cell death via caspase-mediated mechanisms in SK-N-SH cells. To assess the effects of CM272, we conducted qRT-PCR to evaluate the DNMT-1 gene expression levels and performed western blot analyses to examine key proteins, …

Trends And Disparities In Preventative Oral Health Across Demographics: Unveiling And Analyzing 24 Years Of Data In The Us (1999-2023), Tania Anousheh

Undergraduate Student Symposium

Oral health is a fundamental component of our overall well-being. Not only can it greatly influence our physical health but also the emotional, psychological, and socioeconomic aspects of our lives. Despite advancements in dental care, we have noted that there is limited research on how demographic factors impact our oral health behaviors, with underrepresented populations often excluded from large-scale studies. Recognizing this critical gap, we will examine trends in oral health preventive behaviors in the United States from 1999 through 2023, using data from over 106,289 surveys in the National Health and Nutrition Examination Survey (NHANES). We will use RStudio …

The Effects Of Turkesterone On Sleep, Antonio Crisanti, Ava Lukowiak, Tobin Silver Ph.D.

Undergraduate Student Symposium

Introduction

Turkesterone is a naturally occurring compound found in the ajuga turkestanica plant, traditionally used in Central Asia and India for treating various ailments. It has been suggested that supplementation with turkesterone, a type of ecdysteroid, may also have properties that promote improvements in physical and mental performance. Thus, the purpose of this investigation was to determine if four weeks of Turkesterone (500 mg daily dose) supplementation affect sleep quality.

Methods

This randomized, double-blind, placebo-controlled trial aimed to investigate the effects of turkesterone supplementation on mood, sexual functioning, and sleep quality in 30 active individuals (14 males, 16 females). Participants …

Training Alters Joint Power Distributions During Running In National Football League Draft Preparation Players, Jacob Haberer

Undergraduate Student Symposium

The aim of this study was to compare joint-specific contributions to total lower limb joint power during a speed run in American style football players before and after a 6-week National Football League (NFL) draft preparation camp. Fifty-two players performed one 5-second treadmill run at 5.5 – 6.5 m/s before and after camp. Speed was consistent between tests. Bilateral hip, knee, and ankle power generation (positive) and absorption (negative) were calculated from kinematics and kinetics using inverse dynamics. Negative total limb power decreased for both limbs, significantly for the left (Z = - 2.113, p = .035, r = …

Write To Calm: How College Students Use Writing To Manage Stress And Anxiety, Tanvi Rudrangi

Undergraduate Student Symposium

Writing has gained attention for its mental health benefits, particularly among high-stress populations, such as adolescents and young adults. College students, facing academic pressures, social challenges, and transitions to adulthood, are an ideal group for studying the potential therapeutic impact of this practice. This study explores how college students use writing as a tool to manage stress and anxiety. The different forms of writing therapy, a technique involving writing to process emotions and experiences, that are explored in this study include free-form journaling, expressive writing (e.g., letters, personal essays, etc.), creative writing (e.g., poetry, stories, etc.), and structured writing, which …

Spend/Thrift, Jocelyn Saccucci, Mia Alvarado, Matthew Mccall

Undergraduate Student Symposium

In this short documentary, Mako TV talks to college-age South Florida locals to find out why thrifting is becoming popular among them. People cite many different reasons for wanting to purchase items secondhand, with the most prevalent being the lower cost. Many individuals struggle with financial hardships and find thrifting an easier solution than buying items from firsthand stores. However, following the COVID-19 pandemic, there are unique difficulties that owners of local thrift stores face with keeping their stores open. The documentary shows that any stigma that previous generations may have had about thrift stores is not as common with …

My Oath Of Healing And Living, Samuel B. John Mph

be Still

No abstract provided.

Nsu Kpcom Link - Spring 2025 - Volume 4.1, Nova Southeastern University

NSU Florida Link Newsletter

No abstract provided.

Sacred Oath Of Healing - Volume 9

be Still

No abstract provided.

Cultivating Compassionate And Inclusive Care For People With Disabilities, Evelyn Echevarria Cruz, Aila Cordero, Maria Fioletova, Amanda Escudero

be Still

The disparity between physicians' preparedness to treat people with disabilities (PWD) and the prevalence of disabilities is a critical healthcare issue. The 2022 Behavioral Risk Factor Surveillance System reported that over 25% of U.S. adults have a disability, yet many healthcare providers feel unprepared. A poll found that only 40.7% of 714 physicians were confident in providing quality care to PWD, while 61% of 600 surveyed PWD indicated that their providers needed more training. Additionally, only 36% of medical schools included disability education in their curricula, often focusing on brief simulations rather than immersive experiences. To effectively address the diverse …

Cultural And Religious Perspectives On Suicide And Healing, Arielle Friedman

be Still

This essay is built off of a paper I wrote in a college global health course on culture and mental illness. I have always been fascinated by cultural interpretations of illness & believe that as a future physician, it is my responsibility to educate myself and others on the complex interplay between religious ideologies & recognition/management of biological disease in order to provide appropriate patient-centered care.

The Masculine Way, Jessica Asuquo

be Still

This painting was conceptualized after a particularly impactful patient visit. During the visit, the patient described a traumatic event in greater detail, stating that the doctor and I were the first people he had ever spoken to about the event.

I felt both honored and disheartened by this statement. I was honored that this man trusted us with this knowledge. Still, I was immensely sad that he dealt with the trauma of this event alone for decades. I believe he released some of the grief, pain, anger, fear, and hurt when he shared his burden with us, and I will …

Nourishing The Body, Nurturing The Soul, Vidhi Raval

be Still

No abstract provided.

Revealing The Indonesian Crazy Rich Prisoner On Social Media: A Multimodal Discourse Analysis, Krisna Megantari, Heru Nugroho, Dian Arymami

The Qualitative Report

Although flexing is commonly perceived as a negative connotation in society, this phenomenon on digital media industry is fantastically entertaining. This study aims to reveal how the media shapes the phenomenon of Indonesian crazy rich prisoners. Using a multimodal discourse analysis on the YouTube video screenshots were analyzed qualitatively. In dissecting this, three terms are used: representational meaning, interactive meaning, and compositional meaning (Van Leeuwen & Jewitt, 2004). Findings shed some light on three symbolic language themes: hedonism, spectacle society, and homo digitalis. The present study theoretically and practically contributes to the dimensions of the digital media industry, where media …

Benefits Of Psychobiography Training To The Professional And Personal Development Of Psychology Graduate Students, Joseph G. Ponterotto, Dinesh Sharma, Yuki Yamazaki

The Qualitative Report

In recent decades, psychobiography has witnessed a resurgence of activity and publication across many subdisciplines in psychology internationally. One area of recent research has been to evaluate the benefits of training in psychobiography to students’ professional development as perceived by professors and mentors in psychobiography. The present study extends this recent line of research by surveying the perceived impacts of psychobiography training among doctoral students in applied psychology. Twenty-five doctoral students who completed training and research in psychobiography in a summer course over three consecutive years, responded to an open-ended (free response) survey on the impact of conducting psychobiographies on …

The Current - Volume 35 Issue 11, Nova Southeastern University

Student Newspapers

No abstract provided.

Group Dynamics Of Solution-Oriented Virtual Teams In Indonesian Startups: A Thematic Analysis, Tri Astuti, Avin Fadilla Helmi, Bagus Riyono

The Qualitative Report

The relationship between employees is currently undergoing quite significant changes. Initially, relationships were formed through direct interaction in traditional teams. However, in recent decades, relationships have not only occurred directly but can also occur because technology and networks, such as virtual teams, mediate them. The change from traditional teams to virtual teams results in changes in relationship dynamics. With this change, the question asked in this study is, how are group dynamics formed in virtual teams? Through this question, the purpose of the study was identified, namely, to develop a theory of virtual team group dynamics in startup companies. The …

Reliability And Validity In Qualitative Research Revisited And The Role Of Ai, Prokopis A. Christou

The Qualitative Report

The evolving nature of research and the integration of new technologies, such as Artificial Intelligence (AI), introduce new challenges and threats, necessitating a re-examination of the key criteria of reliability and validity. In this paper, I revisit these concepts in the context of qualitative research, highlighting their evolving meanings and significance. I begin by defining reliability and validity and explaining their importance. Following this, I discuss strategies for establishing these criteria within qualitative studies and offer guidelines for maintaining rigor in the current research landscape. While emphasizing the need for human oversight, intervention, and interpretation, I underscore how to ensure …