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Full-Text Articles in Entire DC Network
Together, Apart. A Review Of On (Writing) Families: Autoethnographies Of Presence And Absence, Love And Loss, Edited By Jonathan Wyatt And Tony E. Adams, Jessica Smartt Gullion
Together, Apart. A Review Of On (Writing) Families: Autoethnographies Of Presence And Absence, Love And Loss, Edited By Jonathan Wyatt And Tony E. Adams, Jessica Smartt Gullion
The Qualitative Report
In this essay, I offer a review of the book, On (Writing) Families: Autoethnographies of Presence and Absence, Love and Loss, edited by Jonathan Wyatt and Tony E. Adams. An important contribution to the field of authethnography, this book will appeal not only to scholars of family and of qualitative inquiry, but also to people struggling to find meaning in the crazy complexities of family relationships.
Dynamics Of Marine Bacterial Community Diversity Of The Coastal Waters Of The Reefs, Inlets, And Wastewater Outfalls Of Southeast Florida, Alexandra Mandina Campbell, Jay Fleisher, Christopher D. Sinigalliano, James R. White, Jose V. Lopez
Dynamics Of Marine Bacterial Community Diversity Of The Coastal Waters Of The Reefs, Inlets, And Wastewater Outfalls Of Southeast Florida, Alexandra Mandina Campbell, Jay Fleisher, Christopher D. Sinigalliano, James R. White, Jose V. Lopez
Marine & Environmental Sciences Faculty Articles
Coastal waters adjacent to populated southeast Florida possess different habitats (reefs, oceanic inlets, sewage outfalls) that may affect the composition of their inherent microbiomes. To determine variation according to site, season, and depth, over the course of 1 year, we characterized the bacterioplankton communities within 38 nearshore seawater samples derived from the Florida Area Coastal Environment (FACE) water quality survey. Six distinct coastal locales were profiled – the Port Everglades and Hillsboro Inlets, Hollywood and Broward wastewater outfalls, and associated reef sites using culture-independent, high-throughput pyrosequencing of the 16S rRNA V4 region. More than 227,000 sequences helped describe longitudinal taxonomic …
Perceived Occupational Stressors And The Health Software Professionals In Bengaluru, India, Giridhara R. Babu, Sathyanarayana T. N., Asha Ketharam, Snehendu B. Kar, Roger Detels
Perceived Occupational Stressors And The Health Software Professionals In Bengaluru, India, Giridhara R. Babu, Sathyanarayana T. N., Asha Ketharam, Snehendu B. Kar, Roger Detels
The Qualitative Report
There is limited research on occupational stress and its relation to health from developing countries such as India. This study was done to evaluate work conditions of professionals in two highly productive sectors: the information technology (IT) sector, also known as software development, and Information Technology Enabled Services (ITES), also known as call centers. The study employed thirty-two in-depth interviews. The results indicate the presence of nine stress domains: job control, autonomy, time pressure, length of experience in industry, night shifts, income, appreciation of work, physical environment, work-environment and affective or emotional factors. Global drivers of demand, and local supply …
A Review Of Ototoxic Medications: Implications For Professionals Working With Consumers With Hearing Loss, Shawn P. Saladin Ph.D, Crc, Cpm, Robert B. Perez, Bianca Cruz Pharm.D, Yasar Tasnif Pharm.D, Bcps
A Review Of Ototoxic Medications: Implications For Professionals Working With Consumers With Hearing Loss, Shawn P. Saladin Ph.D, Crc, Cpm, Robert B. Perez, Bianca Cruz Pharm.D, Yasar Tasnif Pharm.D, Bcps
JADARA
Rehabilitation Professionals work with a variety of people with various disabilities and disease states. Oftentimes, those disease states are treated with medications. An understanding of the most common types of medications that can cause ototoxicity, such as aminoglycides, cisplatin and loop diuretics can assist in the vocational rehabilitation process. Rehabilitation professionals are encouraged to establish positive communication with the consumers in order to foster a relationship of trust. Furthermore they are encouraged to establish relationships with Pharmacist for an understanding of the implications of commonly used medications on hearing.
Doctorate Of Osteopathic Medicine Overview, Nova Southeastern University
Doctorate Of Osteopathic Medicine Overview, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
Horizons Fall 2015, Nova Southeastern University
Horizons Fall 2015, Nova Southeastern University
Horizons
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- Seven Is the Magic Number for NSU Sharks 42
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2015 Annual Report, Center For Applied Research On Substance Use And Health Disparities
2015 Annual Report, Center For Applied Research On Substance Use And Health Disparities
Center for Applied Research on Substance Use and Health Disparities Annual Reports
No abstract provided.
Nsu Office Of Research And Technology Transfer Fy 2015 Annual Report, Nova Southeastern University
Nsu Office Of Research And Technology Transfer Fy 2015 Annual Report, Nova Southeastern University
Annual Reports
No abstract provided.
Nova Southeastern University 2015 Annual Report, Nova Southeastern University
Nova Southeastern University 2015 Annual Report, Nova Southeastern University
NSU Annual Reports
No abstract provided.
College Of Pharmacy Program Overview, Nova Southeastern University
College Of Pharmacy Program Overview, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
Marginal Coral Populations: The Densest Known Aggregation Of Pocillopora In The Galápagos Archipelago Is Of Asexual Origin, Iliana B. Baums, Meghann Devlin-Durante, Beatrice A. A. Laing, Joshua S. Feingold, Tyler B. Smith, Andrew Bruckner, Joao Monteiro
Marginal Coral Populations: The Densest Known Aggregation Of Pocillopora In The Galápagos Archipelago Is Of Asexual Origin, Iliana B. Baums, Meghann Devlin-Durante, Beatrice A. A. Laing, Joshua S. Feingold, Tyler B. Smith, Andrew Bruckner, Joao Monteiro
Marine & Environmental Sciences Faculty Articles
Coral populations at distributional margins frequently experience suboptimal and variable conditions. Recurrent El Niño-Southern Oscillation (ENSO) warming events have caused extensive mortality of reef-building corals in the Eastern Pacific, and particularly impacted branching pocilloporid corals in the Galápagos Islands. Pocillopora spp. were previously more common and formed incipient reefs at several locations in the archipelago but now occur as scattered colonies. Here, we report an unusually concentrated aggregation of colonies and evaluate their current genetic diversity. In particular we focus on a large population of 1614 live Pocillopora colonies found in a volcanic lagoon along the southern shore of Isabela …
Innovations Volume 1: Issue 1, Ron And Kathy Assaf College Of Nursing
Innovations Volume 1: Issue 1, Ron And Kathy Assaf College Of Nursing
Innovations Magazine
No abstract provided.
Modeling Flightless Galapagos Seabirds As Impacted By El Nino And Climate Change, Brian Seth Putman
Modeling Flightless Galapagos Seabirds As Impacted By El Nino And Climate Change, Brian Seth Putman
HCNSO Student Theses and Dissertations
Noteworthy species endemic to the Galapagos Islands off Ecuador are two flightless birds, the Galapagos Penguin (Spheniscus mendiculus) and Flightless Cormorant (Phalacrocrax harrisi). Both adapted increased swimming ability at the cost of flight. This however has limited their ability to find richer feeding grounds in times of low resource availability, or to escape potential predators. Their population numbers, though small, were stable. Stress on this stability has increased since human arrival. Various invasive species from pets, farm animals and rats to even mosquito vectors of avian disease accompanied humans. . El Nino Southern Oscillation or ENSO …
Phenotypic Signatures Arising From Unbalanced Bacterial Growth, Cheemang Tan, Robert P. Smith, Ming-Chi Tsai, Russell Schwartz, Lingchong You
Phenotypic Signatures Arising From Unbalanced Bacterial Growth, Cheemang Tan, Robert P. Smith, Ming-Chi Tsai, Russell Schwartz, Lingchong You
Biology Faculty Articles
Fluctuations in the growth rate of a bacterial culture during unbalanced growth are generally considered undesirable in quantitative studies of bacterial physiology. Under well-controlled experimental conditions, however, these fluctuations are not random but instead reflect the interplay between intra-cellular networks underlying bacterial growth and the growth environment. Therefore, these fluctuations could be considered quantitative phenotypes of the bacteria under a specific growth condition. Here, we present a method to identify “phenotypic signatures” by time-frequency analysis of unbalanced growth curves measured with high temporal resolution. The signatures are then applied to differentiate amongst different bacterial strains or the same strain under …
Com Outlook Fall 2014, College Of Osteopathic Medicine
Com Outlook Fall 2014, College Of Osteopathic Medicine
COM Outlook
No abstract provided.
The Adolescent Female's Lived-Experience Of Obesity, Jamie L. Randall-Arell, Rose Utley
The Adolescent Female's Lived-Experience Of Obesity, Jamie L. Randall-Arell, Rose Utley
The Qualitative Report
For adolescent girls, negative messages about obesity and body image from society, media, school, family, and peers are plentiful. Yet the lived-experience of obese adolescent girls has rarely been reported in scientific literature. The purpose of this study was to explore the lived-experience of the obese adolescent female and understand the impact of the messages received. A descriptive phenomenological approach was used to conduct face-to-face interviews with eight adolescent girls, age 11-18. Participants were recruited through network sampling and had a body mass index of 30 or more. Merleau-Ponty’s philosophy of embodied perception guided interpretation and data analysis. Seven themes …
Chronic Illness And Disasters: Development Of A Theoretical Framework, Jacqueline K. Owens, Donna S. Martsolf
Chronic Illness And Disasters: Development Of A Theoretical Framework, Jacqueline K. Owens, Donna S. Martsolf
The Qualitative Report
In a disaster, individuals with chronic illnesses risk poor outcomes. This grounded theory study sought to develop a framework that describes how these individuals manage health-related challenges during disasters. The five phases of disaster response (non-disaster, pre-disaster, impact, emergency, reconstruction) and the individual, local, state, and federal level model served as conceptual frameworks. Using purposive sampling, 30 individuals with chronic illnesses and 10 lay caregivers were recruited from Florida and New Orleans. Data sources included interviews and media data. Constant comparative analysis techniques were used to build the theoretical framework. Transcript analysis suggested that participants used four unique ways to …
Genome-Wide Mycobacterium Tuberculosis Variation (Gmtv) Database: A New Tool For Integrating Sequence Variations And Epidemiology, Ekaterina N. Chernyaeva, Marina V. Shulgina, Mikhail Rotkevich, Pavel Dobrynin, Serguei Simonov, Egor A. Shitikov, Dmitry S. Ischenko, Irina Y. Karpova, Elena S. Kostryukova, Elena N. Ilina, Vadim M. Govorun, Vyacheslav Y. Zhuravlev, Olga A. Manicheva, Peter K. Yablonsky, Yulia D. Isaeva, Elena Y. Nosova, Igor V. Mokrousov, Anna A. Vyazovaya, Olga V. Narvskaya, Alla L. Lapidus, Stephen J. O'Brien
Genome-Wide Mycobacterium Tuberculosis Variation (Gmtv) Database: A New Tool For Integrating Sequence Variations And Epidemiology, Ekaterina N. Chernyaeva, Marina V. Shulgina, Mikhail Rotkevich, Pavel Dobrynin, Serguei Simonov, Egor A. Shitikov, Dmitry S. Ischenko, Irina Y. Karpova, Elena S. Kostryukova, Elena N. Ilina, Vadim M. Govorun, Vyacheslav Y. Zhuravlev, Olga A. Manicheva, Peter K. Yablonsky, Yulia D. Isaeva, Elena Y. Nosova, Igor V. Mokrousov, Anna A. Vyazovaya, Olga V. Narvskaya, Alla L. Lapidus, Stephen J. O'Brien
Biology Faculty Articles
Background
Tuberculosis (TB) poses a worldwide threat due to advancing multidrug-resistant strains and deadly co-infections with Human immunodeficiency virus. Today large amounts of Mycobacterium tuberculosis whole genome sequencing data are being assessed broadly and yet there exists no comprehensive online resource that connects M. tuberculosis genome variants with geographic origin, with drug resistance or with clinical outcome.
Description
Here we describe a broadly inclusive unifying Genome-wide Mycobacterium tuberculosis Variation (GMTV) database, (http://mtb.dobzhanskycenter.org) that catalogues genome variations of M. tuberculosis strains collected across Russia. GMTV contains a broad spectrum of data derived from different sources and related to M. …
Edward Bliss Emerson's Transnational Journal: Danish West Indies, Puerto Rico, New England, 1831-1834, José G. Rigau-Pérez
Edward Bliss Emerson's Transnational Journal: Danish West Indies, Puerto Rico, New England, 1831-1834, José G. Rigau-Pérez
The Qualitative Report
The journal and letters written by Edward Bliss Emerson in the Caribbean provide exciting, idyllic, and at times troublesome visions of that region, but also insights on the life of a sick, poor, religious and brilliant young man. Emerson’s reflections on life in St. Croix remain unquoted, and although brief excerpts from the Puerto Rico portion of the journal appeared in print in 1959 and 1991, his more extensive text supplements the contemporary publications, which only praised the colonial administration. A third, and equally important location, is the implicit base for his perspective – New England in the period of …
Gene Discovery And Data Sharing In Genome Wide Association Analyses: Lessons Form Aids Genetic Restriction Genes, Stephen J. O'Brien, Anton Svitin, Sergey Malov, Nikolay Cherkasov, Pavel Dobrynin, Paul Geerts, Jennifer L. Troyer, Sher L. Hendrickson, Efe Sezgin, Holli Hutcheson
Gene Discovery And Data Sharing In Genome Wide Association Analyses: Lessons Form Aids Genetic Restriction Genes, Stephen J. O'Brien, Anton Svitin, Sergey Malov, Nikolay Cherkasov, Pavel Dobrynin, Paul Geerts, Jennifer L. Troyer, Sher L. Hendrickson, Efe Sezgin, Holli Hutcheson
Biology Faculty Articles
As genome wide association studies plus whole genome sequence analyses for complex human disease determinants are expanding, it seems useful to develop strategies to facilitate large data sharing, rapid replication and validation of provocative statistical associations that straddle the threshold for genome wide significance. At this conference, we shall announce GWATCH, (Genome Wide Association Tracks Chromosome Highway) a web based data release platform that can freely display and inspect unabridged genome tracked association data without compromising privacy or Informed Consent constrictions, allowing for rapid discovery and replication opportunities. We illustrate the utility with HIV-AIDS resistance genes screened in combined large …
Programmed Allee Effect In Bacteria Causes A Tradeoff Between Population Spread And Survival, Robert P. Smith, Cheemang Tan, Jaydeep K. Srimani, Anand Pai, Katherine A. Riccione, Hao Song, Lingchong You
Programmed Allee Effect In Bacteria Causes A Tradeoff Between Population Spread And Survival, Robert P. Smith, Cheemang Tan, Jaydeep K. Srimani, Anand Pai, Katherine A. Riccione, Hao Song, Lingchong You
Biology Faculty Articles
Dispersal is necessary for spread into new habitats, but it has also been shown to inhibit spread. Theoretical studies have suggested that the presence of a strong Allee effect may account for these counterintuitive observations. Experimental demonstration of this notion is lacking due to the difficulty in quantitative analysis of such phenomena in a natural setting. We engineered Escherichia coli to exhibit a strong Allee effect and examined how the Allee effect would affect the spread of the engineered bacteria. We showed that the Allee effect led to a biphasic dependence of bacterial spread on the dispersal rate: spread is …
In Vitro Interaction Of Pseudomonas Aeruginosa With Human Middle Ear Epithelial Cells, Rahul Mittal, M'Hamed Grati, Robert Gerring, Patricia Blackwelder, Denise Yan, Jian-Dong Li, Xue Zhong Liu
In Vitro Interaction Of Pseudomonas Aeruginosa With Human Middle Ear Epithelial Cells, Rahul Mittal, M'Hamed Grati, Robert Gerring, Patricia Blackwelder, Denise Yan, Jian-Dong Li, Xue Zhong Liu
Marine & Environmental Sciences Faculty Articles
Background: Otitis media (OM) is an inflammation of the middle ear which can be acute or chronic. Acute OM is caused by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis whereas Pseudomonas aeruginosa is a leading cause of chronic suppurative otitis media (CSOM). CSOM is a chronic inflammatory disorder of the middle ear characterized by infection and discharge. The survivors often suffer from hearing loss and neurological sequelae. However, no information is available regarding the interaction of P. aeruginosa with human middle ear epithelial cells (HMEECs).
Methodology and Findings: In the present investigation, we demonstrate that P. …
Phasing Out Fossil Fuels, David M. Driesen
2014 Annual Report, Center For Applied Research On Substance Use And Health Disparities
2014 Annual Report, Center For Applied Research On Substance Use And Health Disparities
Center for Applied Research on Substance Use and Health Disparities Annual Reports
No abstract provided.
Evaluation And Integration Of Genetic Signature For Prediction Risk Of Nasopharyngeal Carcinoma In Southern China, Xiuchan Guo, Cheryl Winkler, Ji Li, Li Guan, Minzhong Tang, Jian Liao, Hong Deng, Guy De The, Yi Zeng, Stephen J. O'Brien
Evaluation And Integration Of Genetic Signature For Prediction Risk Of Nasopharyngeal Carcinoma In Southern China, Xiuchan Guo, Cheryl Winkler, Ji Li, Li Guan, Minzhong Tang, Jian Liao, Hong Deng, Guy De The, Yi Zeng, Stephen J. O'Brien
Biology Faculty Articles
Genetic factors, as well as environmental factors, play a role in development of nasopharyngeal carcinoma (NPC). A number of single nucleotide polymorphisms (SNPs) have been reported to be associated with NPC. To confirm these genetic associations with NPC, two independent case-control studies from Southern China comprising 1166 NPC cases and 2340 controls were conducted. Seven SNPs in ITGA9 at 3p21.3 and 9 SNPs within the 6p21.3 HLA region were genotyped. To explore the potential clinical application of these genetic markers in NPC, we further evaluate the predictive/diagnostic role of significant SNPs by calculating the area under the curve (AUC). Results …
Genome-Wide And Differential Proteomic Analysis Of Hepatitis B Virus And Aflatoxin B1 Related Hepatocellular Carcinoma In Guangxi, China, Lu-Nan Qi, Le-Qun Qi, Yuan-Yuan Chen, Zhao-Hong Chen, Tao Bai, Bang-De Xiang, Xiao Qin, Kai-Yin Xiao, Min-Hao Peng, Zhi-Ming Liu, Tang-Wei Liu, Xue Qin, Shan Li, Ze-Guang Han, Zeng-Nan Mo, Regina M. Santella, Cheryl Winkler, Stephen J. O'Brien, Tao Peng
Genome-Wide And Differential Proteomic Analysis Of Hepatitis B Virus And Aflatoxin B1 Related Hepatocellular Carcinoma In Guangxi, China, Lu-Nan Qi, Le-Qun Qi, Yuan-Yuan Chen, Zhao-Hong Chen, Tao Bai, Bang-De Xiang, Xiao Qin, Kai-Yin Xiao, Min-Hao Peng, Zhi-Ming Liu, Tang-Wei Liu, Xue Qin, Shan Li, Ze-Guang Han, Zeng-Nan Mo, Regina M. Santella, Cheryl Winkler, Stephen J. O'Brien, Tao Peng
Biology Faculty Articles
Both hepatitis B virus (HBV) and aflatoxin B1 (AFB1) exposure can cause liver damage as well as increase the probability of hepatocellular carcinoma (HCC). To investigate the underlying genetic changes that may influence development of HCC associated with HBV infection and AFB1 exposure, HCC patients were subdivided into 4 groups depending upon HBV and AFB1 exposure status: (HBV(+)/AFB1(+), HBV(+)/AFB1(-), HBV(-)/AFB1(+), HBV(-)/AFB1(-)). Genetic abnormalities and protein expression profiles were analyzed by array-based comparative genomic hybridization and isobaric tagging for quantitation. A total of 573 chromosomal aberrations (CNAs) including 184 increased and 389 decreased were detected in our study population. Twenty-five recurrently …
Increased Cell Surface Free Thiols Identify Effector Cd8+ T Cells Undergoing T Cell Receptor Stimulation, Samuel Troy Pellom, Ryan D. Michalek, Katie E. Crump, P. Kent Langston, Daniel G. Juneau, Jason M. Grayson
Increased Cell Surface Free Thiols Identify Effector Cd8+ T Cells Undergoing T Cell Receptor Stimulation, Samuel Troy Pellom, Ryan D. Michalek, Katie E. Crump, P. Kent Langston, Daniel G. Juneau, Jason M. Grayson
Biology Faculty Articles
Recognition of peptide Major Histocompatibility Complexes (MHC) by the T cell receptor causes rapid production of reactive oxygen intermediates (ROI) in naïve CD8+ T cells. Because ROI such as H2O2 are membrane permeable, mechanisms must exist to prevent overoxidation of surface proteins. In this study we used fluorescently labeled conjugates of maleimide to measure the level of cell surface free thiols (CSFT) during the development, activation and differentiation of CD8+ T cells. We found that during development CSFT were higher on CD8 SP compared to CD4 SP or CD4CD8 DP T cells. After activation CSFT became elevated prior to division …
A Genome-To-Genome Analysis Of Associations Between Human Genetic Variation, Hiv-1 Sequence Diversity, And Viral Control, Istvan Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. Mclaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio Lopez-Galindez, Concepcion Casado, Andri Rauch, Huldrych F. Gunthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltan Kutalik, Todd M. Allen, Viktor Muller, P. Richard Harrigan, David Heckerman, Amalio Telenti, Jacques Fellay
A Genome-To-Genome Analysis Of Associations Between Human Genetic Variation, Hiv-1 Sequence Diversity, And Viral Control, Istvan Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. Mclaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio Lopez-Galindez, Concepcion Casado, Andri Rauch, Huldrych F. Gunthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltan Kutalik, Todd M. Allen, Viktor Muller, P. Richard Harrigan, David Heckerman, Amalio Telenti, Jacques Fellay
Biology Faculty Articles
HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence variation and plasma viral load (VL), while considering human and viral population structure. We observed significant human SNP associations to a total of 48 HIV-1 amino acid variants (p<2.4 × 10−12). All associated SNPs mapped to the HLA class I region. Clinical relevance of host and pathogen variation was assessed using VL results. We identified two critical advantages to the use of viral variation …2.4>
The Current Volume 24 : Issue 3, Nova Southeastern University
The Current Volume 24 : Issue 3, Nova Southeastern University
Student Newspapers
No abstract provided.
Association Study Of Common Genetic Variants And Hiv- 1 Acquisition In 6,300 Infected Cases And 7,200 Controls, Paul J. Mclaren, Cedric Coulonges, Stephan Ripke, Leonard H. Van Den Berg, Susan Buchbinder, Mary Carrington, Andrea Cossarizza, Judith Dalmau, Steven G. Deeks, Olivier Delaneau, Andrea De Luca, James J. Goedert, David W. Haas, Joshua T. Herbeck, Sekar Kathiresan, Gregory D. Kirk, Olivier Lambotte, Ma Luo, Simon Mallal, Danielle Van Manen, Javier Martinez-Picado, Florencia Pereyra, Francis A. Plummer, Guido Poli, Ying Qi, Pierre Rucart, Manj S. Sandhu, Patrick R. Shea, Hanneke Schuitemaker, Ioannis Theodorou, Fredrik Vannberg, Jan Veldink, Bruce D. Walker, Amy C. Weintrob, Cheryl Winkler, Steven M. Wolinsky, Amalio Telenti, David B. Goldstein, Paul I. W. De Bakker, Jean-Francois Zagury, Jacques Fellay
Association Study Of Common Genetic Variants And Hiv- 1 Acquisition In 6,300 Infected Cases And 7,200 Controls, Paul J. Mclaren, Cedric Coulonges, Stephan Ripke, Leonard H. Van Den Berg, Susan Buchbinder, Mary Carrington, Andrea Cossarizza, Judith Dalmau, Steven G. Deeks, Olivier Delaneau, Andrea De Luca, James J. Goedert, David W. Haas, Joshua T. Herbeck, Sekar Kathiresan, Gregory D. Kirk, Olivier Lambotte, Ma Luo, Simon Mallal, Danielle Van Manen, Javier Martinez-Picado, Florencia Pereyra, Francis A. Plummer, Guido Poli, Ying Qi, Pierre Rucart, Manj S. Sandhu, Patrick R. Shea, Hanneke Schuitemaker, Ioannis Theodorou, Fredrik Vannberg, Jan Veldink, Bruce D. Walker, Amy C. Weintrob, Cheryl Winkler, Steven M. Wolinsky, Amalio Telenti, David B. Goldstein, Paul I. W. De Bakker, Jean-Francois Zagury, Jacques Fellay
Biology Faculty Articles
Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have been interrogated using GWAS, although in generally small samples. Under the auspices of the International Collaboration for the Genomics of HIV, we have combined the genome-wide single nucleotide polymorphism (SNP) data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets (a list of all collaborators appears in Note S1 in Text S1). After imputation using the …