Digital Commons Network^™

Covid-19: Variants, Immunity, And Therapeutics For Non-Hospitalized Patients., Cameron Y.S. Lee, Jon B. Suzuki

HPD Articles

The continuing transmission of coronavirus disease 2019 (COVID-19) remains a world-wide 21st-century public health emergency of concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused greater than 600 million cases of COVID-19 and over 6 million deaths globally. COVID-19 continues to be a highly transmissible disease despite efforts by public health officials and healthcare providers to manage and control the disease. Variants identified in selected worldwide epicenters add to the complexity of vaccine efficacy, overage, and antibody titer maintenance and bioactivity. The identification of the SARS-CoV-2 variants is described with respect to evading protective efficacy of COVID-19 vaccines and …

Cpg Odn/Mangiferin Dual Delivery Through Calcium Alginate Hydrogels Inhibits Immune-Mediated Osteoclastogenesis And Promotes Alveolar Bone Regeneration In Mice., Yingzhi Gu, Yang Hu, Shengyuan Huang, Sunniva Ruiz, Toshihisa Kawai, Yuxing Bai, Xiaozhe Han

HPD Articles

The immune system plays an important role in the skeletal system during bone repair and regeneration. The controlled release of biological factors from the immune system could facilitate and optimize the bone remodeling process through the regulation of the activities of bone cells. This study aimed to determine the effect of the controlled delivery of immunomodulatory biologicals on bone regeneration. Immunostimulatory cytosine-phosphate-guanosine oligodeoxynucleotides (CpG ODN) and glucosylxanthone Mangiferin (MAG)-embedded microbeads were incubated with P. gingivalis-challenged splenocytes, or co-cultured with RAW264.7 cells. The effect of CpG ODN/MAG-containing microbeads on bone regeneration was then tested in vivo in a mouse alveolar bone …

Patient's Perspective Of Shared Decision-Making In Rheumatoid Arthritis Treatment: A Grounded Theory Exploration, Isabela Viana Oliveira, Mariana Martins Gonzaga Nascimento, Cristiane P. Rezende Mrs, Carina M. Neves, Hagabo Mathyell Silva, Ana Luiza Mourawad Cesar, Djenane Ramalho De Oliveira

The Qualitative Report

Current guidelines for rheumatoid arthritis (RA) treatment state that all decisions should be shared with the patient. Therefore, it becomes necessary to understand in-depth how patients with RA with different levels of health literacy and activation feel about sharing the decision with the health professional and how they experience this process. Grounded theory was used. Data collection included semi-structured interviews with 14 patients with RA. From the analysis of the patients’ narratives, four categories were built: “Accepting the changes: non-shared decisions”; “The patient's rationale: why not share?”; “Reaching the requirements for sharing the decision: expanding the patient’s autonomy"; and "Experiencing …

Sharksrx Newsletter Summer 2023, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Development Of Islet Antigen 2 (Ia2) Antibodies Post-Covid-19 Infection: A Sign Of Autoimmunity Or Latent Autoimmune Diabetes Mellitus In Adults (Lada)?, Nick Lee, Praveen Prabhu, Samyukta Swaminath, Sahar S. Amini

HPD Articles

Further antibody tests and laboratory studies showed that the patient met the criteria for latent autoimmune diabetes in adults (LADA). In this case report, we will review the diagnostic workup and management of LADA in an individual following his COVID-19 infection.

Potassium-Incorporated Titanium Oxide Nanoparticles Modulate Human Dendritic Cell Immune Response To Mycobacterium Leprae, Sam Warren, So Yoon Lee, Jose Barragan, Piya Kositangool, Hatsuko Yoshikubo, Jorge Cervantes

HPD Articles

The two polar clinical forms of leprosy, termed tuberculoid and lepromatous, have polarized cellular immune responses with complex immunological distinctions. The predominance of DCs in tuberculoid leprosy has been reported, while the lepromatous pattern of illness is associated with weak activation of local populations of DCs. TiO2 nanoparticles have previously been shown to induce maturation of these cells, leading to an inflammatory response similar to adjuvant usage in vaccine administration. We aimed to evaluate the effect of potassium-incorporated Ti oxide nanostructures, namely KTiOxs, in the response of human monocyte-derived DCs to live M. leprae. Human monocytic cell line dual THP-1, …

Pneumocephalus With Stroke-Like Symptoms: A Rare Complication Of Mastoiditis., Shivaan C. Oomrigar, Raina K. Patel, Robert P. Mas, Jose C. Fernandez, Daniel I. Zapata

HPD Articles

Pneumocephalus is defined as the presence of gas or air in the intracranial space and typically arises as a result of neurotrauma. Clinically, pneumocephalus most often presents asymptomatically but may cause headache, nausea, vomiting, and confusion. Pneumocephalus arising from mastoiditis is an unforeseen complication with only a handful of cases reported. We report a case of an elderly male who presented with stroke-like symptoms in the setting of erosive mastoiditis with pneumocephalus.

Paravertebral Abscess Secondary To Vertebral Osteomyelitis In An Intravenous Drug User., Marianne Cortes, Taylor Mazzei, Anuj Khanna, Kira Fenton, Cristina Savu

HPD Articles

Hematogenous pyogenic vertebral osteomyelitis (VO) is a rare and often fatal complication of osteomyelitis that can affect individuals with underlying medical conditions, hospital-acquired infections, and intravenous (IV) drug abuse. Pyogenic vertebral osteomyelitis can present with generalized back pain, pyrexia, motor weakness, and neurologic deficits. The enigmatic presentation of this condition often results in delays in diagnosis and an increase in mortality. This case report aims to bring awareness to complications of hematogenous pyogenic vertebral osteomyelitis as well as highlight the need for further studies in order to establish standardized treatment. In our report, we depict a case of complicated pyogenic …

Flesh Fly Maggot-Infected Abscess In A Burn Victim Patient In The United States Without A History Of International Travel: A Case Report., Andy Aleman Espino, Erik Aleman Espino, Claudia Aleman Oliva, Gustavo Huaman, Ricardo Castrellon

HPD Articles

This case report describes an uncommon occurrence of myiasis, specifically a maggot-infected abscess, in a patient with reduced skin sensitivity resulting from severe burns. Myiasis is the infestation of live animal tissue by fly larvae, and while it is primarily associated with tropical and subtropical regions, cases acquired within the United States are rare. The presented case involves a 70-year-old male who arrived at the emergency department with an intensely painful, non-healing wound in the left elbow. Upon examination, the wound was found to be infested with numerous live maggots, and subsequent investigations revealed the larvae to be of the …

Exploring The Potential Of Nanotechnology In Pediatric Healthcare: Advances, Challenges, And Future Directions., Hossein Omidian, Kwadwo Mfoafo

HPD Articles

The utilization of nanotechnology has brought about notable advancements in the field of pediatric medicine, providing novel approaches for drug delivery, disease diagnosis, and tissue engineering. Nanotechnology involves the manipulation of materials at the nanoscale, resulting in improved drug effectiveness and decreased toxicity. Numerous nanosystems, including nanoparticles, nanocapsules, and nanotubes, have been explored for their therapeutic potential in addressing pediatric diseases such as HIV, leukemia, and neuroblastoma. Nanotechnology has also shown promise in enhancing disease diagnosis accuracy, drug availability, and overcoming the blood-brain barrier obstacle in treating medulloblastoma. It is important to acknowledge that while nanotechnology offers significant opportunities, there …

A Scoping Review On The Effects Of Covid-19 On Syringe Service Programs In The United States., Dylan Pietrantoni, Crystal Barroca, Sarah Lynch, Jonathan Byrne, Miranda Ortner, Roshni Kotwani, Kolin Limbrick, Paul Kaldas, Michael Moussa, Tatem Fredrickson, Jeffrey Schaefer, Robin J. Jacobs

HPD Articles

The COVID-19 pandemic has had worldwide impacts, including disrupting community services. One interrupted service was syringe service programs (SSPs), community-established initiatives that provide sterile supplies and aid in overcoming addiction in drug-using participants. In the United States (U.S.), SSPs have been key in combating the recent opioid use crisis and associated infections such as the human immunodeficiency virus (HIV) and hepatitis C. While some published reports on the pandemic's overall impacts on SSPs exist, certain aspects such as operational changes and repercussions on staff and participants may still be lacking. Information about the impact of interrupted SSP services due to …

Pandemic Rendering The Transgender People More Vulnerable, As If It Was Not Already Enough: A Qualitative Exploration From Odisha, India, Prachi Parimita Rout, Ajitesh Mathur, Pranaya Kumar Swain

The Qualitative Report

The COVID-19 pandemic impacted people's livelihoods worldwide to an unprecedented magnitude, the most affected being the socially and economically disadvantaged and marginalized communities, including the transgender people that constitute one of the most vulnerable sections that are often subjected to discriminated in various sectors such as education, health, housing, and livelihood opportunities. The present study attempts to offer insights into the impact of the pandemic on the livelihood of transgender people in India, given that the pandemic adversely affected their primary sources of livelihood, such as begging, sex-work, singing, and dancing, due mainly to the restrictive measures: lockdown, shutdown, social/physical …

Scalp, Oral, And Nail Pemphigus Vulgaris: Clinical Characteristics And A Review Of The Literature., Emily Eachus, Lauren E Delamielleure, Samrah Mitha, Taha F Rasul, Arfa Faiz

HPD Articles

Pemphigus vulgaris (PV) is a rare disease that affects the skin and mucous membranes, causing blistering and erosions. Identifying and effectively managing atypical presentations of pemphigus vulgaris can be challenging due to its rarity. We describe a 32-year-old male patient with a medical history including prediabetes, moderate asthma, hyperlipidemia, coccidioidomycosis, and respiratory infections. He was evaluated via telehealth in the allergy and immunology clinic for uncontrolled asthma. Initially, he complained of a whitish film in the mouth while on treatment with fluticasone and salmeterol. He also noted new vesicular lesions on his scalp and body. When evaluated later in the …

Interactions Between Metabolism And Growth Can Determine The Co-Existence Of Staphylococcus Aureus And Pseudomonas Aeruginosa, Camryn Pajon, Marla C. Fortoul, Gabriela Diaz-Tang, Estefania Marin Meneses, Ariane R. Kalifa, Elinor Sevy, Taniya Mariah, Brandon Toscan, Maili Marcelin, Daniella M. Hernandez, Melissa M. Marzouk, Allison J. Lopatkin, Omar T. Eldakar, Robert Smith

Biology Faculty Articles

Most bacteria exist and interact within polymicrobial communities. These interactions produce unique compounds, increase virulence and augment antibiotic resistance. One community associated with negative healthcare outcomes consists of Pseudomonas aeruginosa and Staphylococcus aureus. When co-cultured, virulence factors secreted by P. aeruginosa reduce metabolism and growth in S. aureus. When grown in vitro, this allows P. aeruginosa to drive S. aureus toward extinction. However, when found in vivo, both species can co-exist. Previous work has noted that this may be due to altered gene expression or mutations. However, little is known about how the growth environment could influence the …

A Public Health And Gastroenterological Perspective On The 2022 Monkeypox Outbreak, Rahul Ramakrishnan, Atira Shenoy, Ranganathan Madhavan

InterLACE Research Showcase

No abstract provided.

Transient Premature Ovarian Insufficiency Post-Covid-19 Infection., Colleen N. Gorman, Tori E. Abdalla, Yasmina Sultan, Spencer A. Grabois, Ellen G. Wood

HPD Articles

Anti-ovarian antibodies (AOAs) have been linked to autoimmune premature ovarian insufficiency (POI). This report details a case in which a patient experienced transient POI after a COVID-19 infection and tested positive for AOA. After treatment with oral contraceptives and subsequent high-dose oral corticosteroids, the patient underwent fertility treatment with in vitro fertilization (IVF). A total of 23 oocytes were retrieved. Two euploid blastocysts and three untested blastocysts were successfully created. This report hypothesizes the connection between autoimmune POI, AOA, and COVID-19. Conflicting data have been reported linking COVID-19 and ovarian injury. However, it is suggested that COVID-19 transiently impacts the …

Human Cytomegalovirus (Cmv) Infection Associated With Decreased Risk Of Bronchogenic Carcinoma: Understanding How A Previous Cmv Infection Leads To An Enhanced Immune Response Against Malignancy., Selena Rashid, Amalia Ardeljan, Lexi R. Frankel, Matthew Cardeiro, Enoch Kim, Brittany M. Nagel, Kazuaki Takabe, Omar Rashid

HPD Articles

INTRODUCTION:  Cytomegalovirus (CMV) causes a long-lasting, asymptomatic infection that reportedly has both advantageous and deleterious effects on tumor progression. The purpose of this study was to evaluate the correlation between CMV infection and the incidence of bronchogenic carcinoma.

METHODS: The study was conducted using a Health Insurance Portability and Accountability Act (HIPAA) compliant national database to identify patients both with and without histories of CMV infection using International Classification of Diseases (ICD-10 and ICD-9) codes. Access to the database was granted by Holy Cross Health, Fort Lauderdale for the purpose of academic research with standard statistical methods used to analyze …

Covid-19 Vaccine Hesitancy In Pregnant Women From Marginalized Communities, Leona Markose

Undergraduate Student Symposium

Vaccination is known to be one of the most successful public health measures currently available that decreases numbers of mortality and morbidity of various diseases across the globe. Despite the success that has been found in controlling infectious disease through herd immunity from vaccinations, a study published in 2021 in Nature Medicine shows willingness to get a COVID-19 vaccine is higher in developing countries (80% of respondents) than in the US (65% of respondents). This demonstrates a rising problem especially prevalent among developed countries of a voluntarily under vaccinated population that do not believe vaccination is a method that is …

Research In Anatomy And Physiology During Covid-19: Global Lessons Learnt And Future Recommendations, Jeet Patel, Harsh Chheda

Undergraduate Student Symposium

The persistent Coronavirus Infectious Disease 2019 (COVID-19) pandemic caused significant disruptions of research studies within the fields of Anatomy and Physiology. As the pandemic resulted in many governmental and institutional restrictions, it became increasingly challenging to pursue research in general. Disciplines like Anatomy and Physiology that require kinesthetic/tactile application of concepts or testing hypotheses through hands-on active engagement were either halted or slowed down, as the new social guidelines and risks to certain groups of people hindered up-to-date researchdata collection. This called for the design and adoption of innovative scientific and technological research tools and protocols. An effort to help …

Implications Of Covid-19 In Global Anatomy And Physiology Education: A Comprehensive Analysis, Sneh Patel, Sean Mahajan

Undergraduate Student Symposium

Owing to the Coronavirus Infectious Disease 2019 (COVID-19), the higher education sector worldwide saw a significant disruption in several disciplines – especially the ones in STEM and healthcare sciences that require active, experiential learning via practical application of concepts centering around Anatomy and Physiology. Dynamic instructional and technological interventions took place rapidly in an effort to minimize the adverse repercussions of moving away from traditional means of education in these critical scientific fields. COVID-19 necessitated administrators, faculty, students, and interns at colleges, universities, medical/healthcare science programs and residencies to pursue teaching, learning, and assessment of Anatomy and Physiology courses/curricula through …

Analysis Of Attitudinal Student Learning Benefits From A Course-Based Undergraduate Research Experience (Cure) Adapted For Online Format, Ambika Kapil, Luis C. Gonzalez Isoba, Niraj Pathak, Arthur Sikora, Santanu De

FDLA Journal

Course-based Undergraduate Research Experiences (CUREs) are an increasingly utilized model for exposing students to research. The lack of robust assessments is a major hurdle to wider adoption of CUREs. The Coronavirus Infectious Disease 2019 (COVID-19) pandemic necessitated a drastic shift of in-person courses to the online format. Using the Participant Perception Indicator (PPI) survey, we measured students’ self-reported changes in learning from such a biochemistry course at a large university in south Florida based on the Biochemistry Authentic Scientific Inquiry Lab (BASIL) model. By doing this, we were able to better understand the student-benefits of CUREs and how these benefits …

Personalizing Prevention: Advances In Pharmacotherapy For Hiv Prevention., Marisa Brizzi, Elizabeth Sherman, Sarah B. Green, Diana N. Nowicki, Emily N. Drwiega, Melanie R. Nicol, Daniel B. Chastain, Eric G. Sahloff, William R. Truong, David Cluck, Melissa E. Badowski, Sarah M. Michienzi, Spencer H. Durham

HPD Articles

The HIV epidemic continues to pose a significant burden on the healthcare system. Although the incidence of annual new infections is decreasing, health disparities persist and most new infections remain concentrated into different racial, ethnic, and minority groups. Pre-exposure prophylaxis (PrEP), which involves those at high risk of acquiring HIV to take chronic medications to prevent acquisition of the virus, is key to preventing new HIV infections. The purpose of this article is to review medication therapies for PrEP and examine their role in personalizing PrEP in different patient populations. Additionally, new medications currently under development for PrEP are reviewed, …

The Abrupt Educational Switch: Impact Of Covid-19 And Lessons Learned For Health Science Faculty And Students, Kathleen Klein, Marylou Galantino, Tara Crowell, Renne Cavazza

Internet Journal of Allied Health Sciences and Practice

Purpose: The abrupt educational transition from in-class to virtual instruction during spring of 2020 found many faculty and students in uncharted territory. The purpose of this study was to survey both faculty and students in the School of Health Sciences to better understand the switch from face-to-face instruction to remote learning. Methods: Both qualitative and quantitative data was collected regarding this experience. The first task was to identify faculty’s responses and actions taken, perception of alternative teaching experience and impact on student learning, determine needs to prepare and address new course design and delivery, and explore perception of changes to …

Sources Of Stress, Burnout, And Career Decisions Of Male Health And Nursing Professionals: A Qualitative Inquiry Of The Challenges During The Covid-19 Pandemic, Luis Miguel Dos Santos

The Qualitative Report

The human resources and workforce shortage of registered health and nursing professionals has been a long-term problem in health systems internationally, particularly during the COVID-19 pandemic. Many health and nursing professionals face stress and burnout, which may influence their career decisions and long-term human resources development. The purpose of this study is to investigate and understand the relationship(s) between sources of stress and the reasons why male health and nursing professionals decide to leave the profession within the next six months. With the employment of the social cognitive career and motivation theory and general inductive approach with 40 male health …

Monkeypox Proctitis: A Case Of Targeted Treatment With Tecovirimat., Premalkumar Patel, Cynthia Espinosa, Varsha Konyala, Nicholas S. Camps, Estafenia Cecilio, Aakangsha Jain, Claudio Tuda

HPD Articles

Monkeypox (MPX) is an exanthematous disease first identified in the 1950s, associated with animals in Central and Western Africa, and has since been found sporadically worldwide. In May 2022, a returning family from Nigeria tested positive for MPX, which marked the onset of the current outbreak. It has now become a disease of concern in most parts of the world. The current standings are nearing 90,000 cases, with numbers increasing daily. The United States reported 29,711 cases so far. The characteristic exanthem of MPX is known to be present ubiquitously on the human habitus, with recent reports describing anogenital and …

Long Covid & Antidepressants, Rafael Rivas-Vázquez, Enrique J. Carrazana, Mark A. Blais, Gustavo J. Rey, Emma Rivas-Vázquez, Alan Quintana

Faculty Articles

Three years into this historic pandemic, the scientific and healthcare communities continue to learn a great deal regarding COVID-19, the disease that is produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The most urgent and immediate focus has been on vaccine development for disease prevention/mitigation and on identification of effective therapeutic interventions for acute phase of illness. However, attention is increasingly being placed on formulating treatment strategies for individuals who are post-COVID-19 and experiencing a syndrome of persistent cognitive, somatic and behavioral symptoms that is being referred to as long COVID. In addition to identifying novel compounds that …

Using Research To Save The Anthropocene: A Review Of Michael Quinn Patton’S Blue Marble Evaluation: Premises And Principles, Richard H. Rogers

The Qualitative Report

Patton’s (2020) book, Blue Marble Evaluation: Premises and Principles, will expand your knowledge of evaluation, research, the Anthropocene, global issues, and the planet. In 2023, it is important that we understand the impact of our past and present actions on the planet and the future of humanity. Patton’s principles, supported with comics, figures, and exhibits, will grow evaluators in the knowledge, skills, and mindset to make a positive future difference in our planet and humanity. Methodologists will appreciate a new way to examine evaluation and grow as professionals while professors will have a source to add to their course …

Avascular Necrosis As A Sequela Of Covid-19: A Case Series., Sarthak Parikh, Osmanny Gomez, Ty Davis, Zachary Lyon, Arturo Corces

HPD Articles

Avascular necrosis (AVN) is a degenerative bone condition characterized by cellular death and bone collapse from compromised subchondral blood circulation. AVN begins with vascular interruption, hypertension, intravascular occlusion, or extravascular compression which reduces bone circulation. Although corticosteroids are frequently used to treat acute COVID-19 infections, patients are prone to its side effects, particularly AVN. Furthermore, COVID-19 produces coagulopathies, specifically hypercoagulability, that may contribute to venous thrombosis, which may serve as the impetus of AVN. While the literature discussing COVID-19, AVN, and corticosteroid use is not conclusive, patients being treated with corticosteroids for COVID-19 are at an increased risk for AVN …

Sight The Mite: A Meta-Analysis On The Diagnosis Of Scabies, Qaas Shoukat, Ahraz Rizvi, Waseem Wahood, Skyler Coetzee, Algevis Wrench

HPD Articles

This meta-analysis was performed to assess the efficacy of the diagnostic tests for scabies infections that are currently in wide use. Scabies is most commonly diagnosed through clinical presentations; however, due to the wide array of symptoms, diagnosis is difficult. The most commonly used diagnostic test is skin scraping. However, this test relies on correctly selecting the site of mite infection for sampling. Due to the mobile nature of a live parasitic infection, the mite can often be missed based on its current location within the skin. The goal of this paper is to determine if a gold standard confirmatory …

Experiences Of Covid-19 Recovered Patients: A Qualitative Case Study From A Hotspot In Saudi Arabia, Abdulrahman Alhajjaji Alhajjaji, Ahmad Kurdi, Sultan Faqeh, Safwan Alansari, Akrm Abdulaziz, Moayad Allihyani, Omar Almaghamsi, Ejaz Cheema, Majid Ali

The Qualitative Report

It is difficult to maintain social distancing in highly populated areas where people live in proximity. This study aimed to qualitatively explore experiences of COVID-19 recovered patients residing in one such area. We employed semi-structured face-to-face interviews. An interview guide was developed, validated, piloted, and minor changes were made. People living in this area, above 18 years of age, and recovered from COVID-19 were approached for the interviews, 11 of them were recruited to be interviewed, and their verbal informed consent was audio recorded. The interviews were conducted in the Arabic language in a semi-private area of the community center, …