Digital Commons Network^™

Reducing Inoculum Effect By Modulating Growth Productivity Through The Superpathway Of Purine, Pyrimidine And Histidine Synthesis In Escherichia Coli, Ruth Thomas, Daniella M. Hernandez, Melissa Marzouk

Undergraduate Student Symposium

Antibiotic overuse has driven the evolution of multiple antibiotic-resistant bacteria that complicate infections that were once easily treatable. While mechanisms by which individual bacterium resist or tolerate antibiotics are well explored, less studied are the mechanisms by which populations of bacteria tolerate antibiotics as a collective. One such mechanism bacteria employ to tolerate antibiotic treatment as a collective is the inoculum effect (IE). We recently discovered that growth productivity, which describes the relationship between ATP production and growth rate, can account for IE for multiple antibiotics and pathogens. However, the underlying pathways for determining growth productivity have yet to be …

A National Cross-Sectional Survey To Assess The Education And Training Needs Of Allied Health Professionals And Clinical Psychologists Delivering Rehabilitation For Children And Young People Affected By Covid-19 In The United Kingdom, Jennifer Gardner, Zoe Berger, Graeme O'Connor, Anne Gordon, Philippa Wright

Internet Journal of Allied Health Sciences and Practice

Purpose: In the paediatric population there are two conditions associated with COVID-19 infection: Paediatric Multisystem Inflammatory Syndrome (PIMS-TS) and Paediatric Long-COVID. The emerging clinical picture of children and young people (CYP) affected by COVID-19 has highlighted the vital role Allied Health Professionals (AHP’s) and clinical psychologists have in supporting rehabilitation. Therefore, it is imperative that AHP’s and Psychologists working across all clinical sectors have the knowledge, experience and training to meet the rehabilitation needs of CYP who have been affected by COVID-19. The aim of this cross-sectional survey was to explore AHPs and psychologists’ views on CYP rehabilitation needs and …

Nsu Health Professions Division 2023-2024 Course Catalog, Nova Southeastern University

HPD Course Catalogs

Nova Southeastern University Health Professions Division:

• Dr. Kiran C. Patel College of Osteopathic Medicine
• College of Pharmacy
• College of Optometry
• Dr. Pallavi Patel College of Health Care Sciences
• College of Dental Medicine
• Ron and Kathy Assaf College of Nursing
• Dr. Kiran C. Patel College of Allopathic Medicine

Summer Fall 2024, Nova Southeastern University

KPCOM SGA Rounds

No abstract provided.

2024-2025 Halmos College Of Arts And Sciences Graduate Program Catalog, Nova Southeastern University

Halmos College of Arts and Sciences Course Catalogs

No abstract provided.

College Of Computing And Engineering Graduate Catalog 2024-2025, Nova Southeastern University

College of Psychological Services / College of Psychology Postgraduate Student and Course Catalogs

No abstract provided.

Black Teachers, Black Students, And Cultural Brokering: Leveraging Positionality To Strengthen Academic Identity, Shakasha L. Stevenson

Theses and Dissertations

This study utilized a phenomenological photovoice approach to understand the lived experiences of veteran Black high school teachers. Black teachers are positioned to serve as cultural brokers to support the academic identity of Black students. The prevalence of symbolic violence in the Eurocentric curriculum and other curricular practices continues to hinder successful outcomes for Black students. The study leverages the experiences of Black teachers to understand how their positionalities influence their decision-making and pedagogical practices.

The literature review explored research on the social and political implications of Black education, Black identity development, cultural brokering, and academic identity. More specifically, the …

A Qualitative Descriptive Study Of The Perspectives Of Health Care Leaders Concerning The Implementation Of Telehealth, Gary Gerard Camille

Theses and Dissertations

The purpose of this qualitative descriptive study was to explore how healthcare leaders on the east coast United States described the role of implementing, the outer setting, inner setting, individual characteristics, and the process when implementing telehealth in a patient-centered care environment in hospitals and healthcare facilities.

The study used a qualitative method with a descriptive design to capture the descriptions of the participant’s experience during the implementation of telehealth in a patient centered care environment in different health care facilities in east coast of the United States. Due to the onset of the Covid-19 pandemic, the interview sessions and …

Prolonged Antibiotic Use In A Preclinical Model Of Gulf War Chronic Multisymptom-Illness Causes Renal Fibrosis-Like Pathology Via Increased Micro-Rna 21-Induced Pten Inhibition That Is Correlated With Low Host, Ayushi Trivedi, Dipro Bose, Punnag Saha, Subhajit Roy, Madhura More, Jonathan Skupsky, Nancy G. Klimas, Saurabh Chatterjee

HPD Articles

Gulf War (GW) veterans show gastrointestinal disturbances and gut dysbiosis. Prolonged antibiotic treatments commonly employed in veterans, especially the use of fluoroquinolones and aminoglycosides, have also been associated with dysbiosis. This study investigates the effect of prolonged antibiotic exposure on risks of adverse renal pathology and its association with gut bacterial species abundance in underlying GWI and aims to uncover the molecular mechanisms leading to possible renal dysfunction with aging. Using a GWI mouse model, administration of a prolonged antibiotic regimen involving neomycin and enrofloxacin treatment for 5 months showed an exacerbated renal inflammation with increased NF-κB activation and pro-inflammatory …

Nutritional And Wellness Strategies For Neurological And Psychiatric Recovery From Postcovid Syndrome And Post-Acute Sequelae Of Covid-19, Jeffrey Schaefer, Deepesh Khanna

HPD Articles

The post-COVID syndrome was officially recognized as a disability under the Americans with Disabilities Act, indicating that this syndrome has made a significant impact on our populace. Also, post-acute sequelae of COVID-19 (PASC) is a term that describes the long-term health problems that some people experience after being infected with the virus that causes COVID-19. These problems can last for weeks, months, or even years, and can affect various parts of the body, such as the heart, lungs, brain, and blood vessels. This narrative review paper utilized the PubMed database to explore the pathophysiology of post-COVID syndrome's neurological and psychiatric …

Forward Thinking And Adaptability To Sustain And Advance Ipecp In Healthcare Transformation Following The Covid-19 Pandemic, Hossein Khalili, Jyotsna Pandey, Sylvia Langlois, Vikki Park, Ryan Brown, Alla El-Awaisi, Kathleen Macmillan, Shelley Cohen Konrad, Brittany Daulton, Christopher Green, Giray Kolcu, Charlotte Mccartan, Gina Baugh, Andrea Pfeifle, Lisa Wetzlmair, Inci Kolcu, Anthony P. Breitbach

Internet Journal of Allied Health Sciences and Practice

The proliferation of the novel SARS-CoV-2 (COVID-19) virus across the globe in 2020 produced a shared trauma internationally of unprecedented devastation, disruption, and death. At the same time, the pandemic has been a transformation catalyst accelerating the implementation and adoption of long overdue changes in healthcare education and practice, including telehealth and virtual learning. The COVID-19 pandemic has placed healthcare at a crossroads, either viewing it as a temporary situation that requires short-term solutions, or as a major disruption that presents opportunities for innovation for sustainable development and transformation. As COVID-19 transitions from pandemic to endemic, we have a unique …

Evaluating The Effectiveness Of The Internal Transcribed Sequences (Its) As Dna Barcodes To Estimate Fungal Diversity, Jailisa Linares

All HCAS Student Capstones, Theses, and Dissertations

Universal phylogenetic markers such as the nuclear ribosomal internal transcribed sequences (ITS), specifically ITS1 and ITS2, are routinely used to estimate fungal diversity in environmental samples. However, numerous studies report differences in the performance and efficacy of ITS1 and ITS2 in documenting fungal diversity. To better understand the implications of using ITS1 versus ITS2, a comprehensive representation of the diverse fungal taxa was necessary to conduct a meta-analysis of their use across multiple fungal taxa. In order to address this, a thorough literature review was conducted to compare and contrast the use of ITS1 and ITS2 as effective DNA barcodes. …

The Endoparasite Fauna Of Mesopredatory Mesopelagic Teleosts, Alexander U. Rayburn

All HCAS Student Capstones, Theses, and Dissertations

The ecology of the mesopelagic zone is an understudied area of the open ocean, with few diet studies even for dominant fish species. Since endoparasites are generally transmitted trophically, descriptions of the parasite communities within fishes can often provide additional insights on food web interactions. This project assesses the endoparasite faunal community of mesopredatory mesopelagic teleosts to better understand mesopelagic food webs in the South Atlantic Bight. Fishes in the Families Alepisauridae (lancetfishes), Gempylidae (snake mackerels), Bramidae (pomfrets), and Scombrolabracidae (longfin escolar) are frequent bycatch in the pelagic longline fishery targeting swordfish Xiphias gladius and thunnid tunas, yet the ecology …

Florida's Summer Institute In Biostatistics And Data Science Program Experience, David Giordano

Trick to the Treat of Internships and Research

The Summer Institute in Biostatistics and Data Science, sponsored by the NHLBI and NIAID, offers a comprehensive six to seven-week training program. This program provides classroom instruction, career mentoring, and hands-on data analysis using clinical study data related to infectious, immune-mediated, and chronic diseases. It's designed to address the increasing demand for biostatisticians and data scientists, targeting undergraduates and early graduate students to consider graduate programs in these fields. The curriculum includes intensive biostatistical training, introducing students to statistical methods' principles and applications in biomedical and clinical research.

Sharksrx Newsletter Fall 2023, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Long-Term Evaluation Of Clinical Success And Safety Of Omadacycline In Nontuberculous Mycobacteria Infections: A Retrospective, Multicenter Cohort Of Real-World Health Outcomes., Amer El Ghali, Taylor Morrisette, Sara Alosaimy, Kristen Lucas, Maria G Tupayachi-Ortiz, Raaga Vemula, Carly Wadle, Julie V Philley, Carlos Mejia-Chew, Yasir Hamad, Ryan W Stevens, John D Zeuli, Andrew J Webb, Christina T Fiske, Anahit Simonyan, Christo L Cimino, Mehriban Mammadova, Virginia E Umana, Rodrigo Hasbun, Saira Butt, Kyle C Molina, Michael Thomas, Emily A Kaip, Jeannette Bouchard, Tristan W Gore, Catessa Howard, M Gabriela Cabanilla, Dana J Holger, Jeremy J Frens, Melissa Barger, Aaron Ong, Keira A Cohen, Michael J Rybak

HPD Articles

Infections due to nontuberculous mycobacteria (NTM) continue to increase in prevalence, leading to problematic clinical outcomes. Omadacycline (OMC) is an aminomethylcycline antibiotic with FDA orphan drug and fast-track designations for pulmonary NTM infections, including Mycobacteroides abscessus (MAB). This multicenter retrospective study across 16 U.S. medical institutions from January 2020 to March 2023 examined the long-term clinical success, safety, and tolerability of OMC for NTM infections. The cohort included patients aged ≥18 yr, who were clinically evaluable, and` had been treated with OMC for ≥3 mo without a previous diagnosis of cystic fibrosis. The primary outcome was 3 mo clinical success, …

Understanding Expatriates' Cultural Adjustment And Performance In International Assignments, Iskra Reic

The Qualitative Report

The aim of this research is to explore the experience of expatriates about cultural differences between home and host countries through a narrative inquiry. There is not enough information in the literature about expatriates’ experiences and how they see the role of cultural differences, cultural distance and cultural competences in adapting to international assignments. Therefore, main research question was how expatriates working in a large multinational pharmaceutical company perceive the role of cultural differences and cultural competencies in their adjustment and performance. A total of 12 expatriates from different home countries on assignment in different host countries participated in the …

Cytomegalovirus Esophagitis In An Immunocompromised Patient, Adya A. Ali, Sheela Anasseri, Jaafar Abou-Ghaida, Leslie Walker, Tye Barber

HPD Articles

Cytomegalovirus (CMV) can present with end-organ disease (EOD), particularly in patients with a CD4 cell count <50/mm3. While EOD in immunocompromised patients commonly presents as CMV retinitis (30%) and CMV colitis (5-10%), CMV esophagitis is rare. CMV is the third most common infectious esophagitis following Candida and Herpes Simplex. CMV esophagitis presents with odynophagia, dysphagia, and abdominal pain. Endoscopic exam may reveal large, linear distal esophageal ulcers. Histopathology or serology studies are diagnostic, though serology may be unreliable in the extremely immunosuppressed. Current treatment consists of antivirals such as ganciclovir and valganciclovir. Esophageal disease due to CMV carries a poor prognosis in the immunocompromised. We present the case of a 56-year-old male with a medical history of HIV/AIDS and stage III rectal squamous cell cancer who presented with shortness of breath, weakness, and chronic diarrhea. His HIV was previously well-controlled on antiretroviral therapy. However, due to his malignancy, he was undergoing treatment with chemotherapy and radiation. Initial labs revealed a CD4 count of 42. His clinical course consisted of Escherichia coli septicemia, new-onset atrial fibrillation with a rapid ventricular response, worsening pneumonia, possible metastasis, progressive diarrhea, and potential oropharyngeal candidiasis. Despite several broad-spectrum antimicrobial regimens, he remained symptomatic with new complaints of dysphagia and odynophagia. Eventually, the appearance of vesicular lesions on the lips and a repeat CD4 count of 13 garnered a suspicion of HSV or CMV. This complicated case highlights the necessity for a high index of suspicion of rare manifestations of CMV EOD in an immunocompromised patient presenting with confounding …

Post-Hysteroscopy Ruptured Tubo-Ovarian Abscess With Atypical Bacteremia: A Case Report, Jillian H. Linck, Wanda I. Torres, Shailja T. Dayal

HPD Articles

Hysteroscopies are commonly performed in the diagnosis and treatment of patients with abnormal uterine bleeding. Current research suggests a low rate of all types of complications following hysteroscopies. The rate of infectious complications has been reported as exceptionally low. We present a case of tubo-ovarian abscess with Escherichia coli bacteremia and eventual abscess rupture in a 51-year-old gravida 3, para 2012 (G3P2) woman who underwent a hysteroscopy with concurrent polypectomy. The patient had no risk factors that have historically been attributed to the development of post-hysteroscopy infection, such as a history of pelvic inflammatory disease or endometriosis. The patient also …

An Incidental Finding Of A Glucagon-Like Peptide 1 (Glp-1)-Induced Acute Kidney Injury: A Case Report., Andy Espino Aleman, Erik Aleman Espino, Claudia Aleman Oliva, Hamlet Monteagudo, Odalys Frontela

HPD Articles

Acute kidney injury (AKI) involves a rapid decline in kidney function, classified into prerenal, intrarenal, and postrenal causes. Drug-induced AKI's complex pathophysiology includes altered hemodynamics, inflammation, crystal deposition, hemolysis, and rhabdomyolysis. This report details a 42-year-old female with hypertension and diabetes who, following a dog bite, exhibited reduced kidney function (GFR: 16 mL/min/1.73m

The Lasting Effects Of Covid-19 On The Progression Of Metabolic Dysfunction-Associated Steatotic Liver Disease, Sean Backer, Deepesh Khanna

HPD Articles

It is estimated that around 30% of the population living in Western countries has metabolic dysfunctionassociated steatotic liver disease (MASLD), a spectrum of pathology (not attributed to alcohol/substance intake) initiated by steatosis and progression toward inflammation and irreversible fibrosis metabolic dysfunction-associated steatohepatitis (MASH). With inflammation being a key component of the transition to MASH, it raises the question of whether the ongoing COVID-19 pandemic, which has notoriously induced hyperinflammatory states, may influence the progression of MASLD. Specifically, it remains unclear if the potential chronic sequelae of COVID-19 in patients who recovered from it may increase the predisposition for MASH. Since …

Inferior Vena Cava Thrombus Associated With Renal Cell Carcinoma With An Atypical Radiological Presentation: A Case Report, Kareem Elgendi, Mohamadhusni Zarli, Sohaib Ahmed, Nicole Szell

HPD Articles

Renal cell carcinoma (RCC) is characterized by the development of kidney masses, which can lead to various long-term complications. Among the extrarenal manifestations associated with RCC, the formation of a thrombus within the inferior vena cava (IVC) is particularly prevalent due to the substantial tumor burden imposed by the kidneys. In this report, we present an exceptional case involving an 80-year-old male patient who presented with an intravascular thrombus within the inferior vena cava (IVC), which originated from RCC. The diagnosis of RCC was conclusively established through core needle biopsy and subsequent tumor marker staining. Remarkably, despite the confirmation of …

Severe Covid-19 Infection In An Infant With 8p Inverted Duplication/Deletion Syndrome: Is Vaccination Still A Debate?, Andrew M. Joseph, Monica Karas, Ernesto Joubran, Yaseen O. Ramadan, Blakley A. Fowler

HPD Articles

Despite having a milder course of coronavirus disease 2019 (COVID-19) in comparison to adults, children are at risk for more significant complications, including acute neurological, renal, respiratory, and cardiovascular complications. Acute complications can manifest as encephalopathy, renal injury, interstitial pneumonia, and heart failure. However, the most severe complication is multisystem inflammatory syndrome in children, which often requires intensive care to manage the subsequent respiratory failure. Moreover, children with comorbidities such as chronic lung disease, neurological disorders, and cardiovascular disease are at an elevated risk of morbidity and mortality. Here, we present the case of an 11- month-old white female patient, …

A Narrative Review Of The Many Psychiatric Manifestations Of Neurosyphilis: The Great Imitator, Baneet Kaur, Deepesh Khanna

HPD Articles

Neurosyphilis is an infection of the central nervous system caused by the spirochete, Treponema pallidum. New syphilis infections have been increasing around the world each year. This disease was much of a concern in the pre-penicillin era, where when left untreated many cases progressed to tertiary syphilis which can commonly manifest as neurosyphilis. Of particular interest, neurosyphilis has been linked to masquerading itself as various psychiatric conditions. This narrative review focuses on exploring psychiatric manifestations of neurosyphilis as well as the importance of screening in psychiatric settings and clinicians maintaining high clinical suspicion of the disease. A systematic search …

A Case Of Fournier’S Gangrene: A Rare, Lethal Skin Infection, Aditi Chokshi, Laura Ziton

HPD Articles

Fournier’s gangrene (FG) is a rare form of necrotizing fasciitis that is characterized by fascial necrosis of the genitalia or perineum. FG typically results as a complication of genital or anorectal abscess, pressure sore, or surgical site infections. Many patients present with no symptoms, whereas other patients may present with non-specific symptoms such as pain or erythema in the genital or perianal regions. We present a case of FG in a 76-year-old male. Our patient presented initially with only complaints of perianal and groin pain. Upon imaging and skin examination, a diagnosis of Fournier’s gangrene was made. However, due to …

Cytokine Data For Cytokine Profile Assessment From Peruvian Pinniped (Arctocephalus Australis And Otaria Byronia) Plasma, Mykenzee Munaco, Milton Levin, Michael Adkesson, Susana Cárdenas-Alayzad, Dimitrios G. Giarikos, Amy C. Hirons

SECLER Data

Large colonies of two vulnerable, sympatric pinniped species, Peruvian fur seals (Arctocephalus australis Peruvian subpopulation; PFS) and South American sea lions (Otaria byronia; SASL), reside and reproduce in Punta San Juan, Peru (PSJ) where they are exposed to stressors such as contaminants and El Niño Southern Oscillation (ENSO) events. The use of cytokines as immune biomarkers can be indicative of an animal’s health and function by allowing for the assessment of an individual's cytokine balance as type I helper T cells (Th1) or type II helper T cells (Th2) dominant. Utilizing archived pinniped plasma samples from 2009-2019 …

Parasites Versus Predation: The Role Of Chronic And Acute Parasite Exposure In Infection Risk And Anti-Predator Behavior, Delaney Farrell

All HCAS Student Capstones, Theses, and Dissertations

Parasites with complex, multi-host lifecycles often engage in host behavior manipulation to increase transmission between successive hosts. In intermediate fish hosts, previous research has measured increased frequency of conspicuous behaviors, decreased swimming performance, and reduced antipredator behavior, which would collectively increase the fish’s risk of predation. In ecosystems where this type of parasite increased trophic transmission (PITT) occurs, parasites can play a substantial role in food webs. In this study, I investigate how chronic versus acute exposure to the trematode Euhaplorchis sp. A. affects the antipredator behavior of the Gulf killifish Fundulus grandis. Using a fully crossed design, I …

Cytokine Profiles In Peruvian Pinnipeds And Their Relationships With Environmental Stressors, Mykenzee L. Munaco

All HCAS Student Capstones, Theses, and Dissertations

Large colonies of two vulnerable, sympatric pinniped species, Peruvian fur seals (Arctocephalus australis Peruvian subpopulation; PFS) and South American sea lions (Otaria byronia; SASL), reside and reproduce in Punta San Juan, Peru (PSJ) where they are exposed to stressors such as environmental contaminants and El Niño-Southern Oscillation (ENSO) events. Cytokine concentrations can be indicative of an animal’s health and immune function by allowing for immunoresponse characterization as Th1 or Th2 dominant. Utilizing an archived pinniped plasma collection of samples from 2009-2019 (n=148), 13 cytokines were analyzed in PFS and SASL: GM-CSF, IFN-γ, KC-like, MCP-1, TNF-α, IL-2, IL-6, …

A Rare Case Of Folate Deficiency-Induced Subacute Combined Degeneration Of The Spinal Cord: A Case Report., Lohitha Guntupalli, Andrew Lurie, Veenah Stoll, Luis Daniel Lugo

HPD Articles

Folate deficiency is a rare cause of subacute combined degeneration (SCD). SCD is characterized by demyelination of the dorsal and lateral columns of the cervical and thoracic spine most commonly caused by vitamin B12 deficiency. Folate deficiency, which can be clinically indistinguishable from B12 deficiency, leads to a variety of presentations, including absent vibratory sensation and proprioception, sensory ataxia, and progressive motor weakness. Recognizing the clinical sequelae of SCD is essential for timely diagnosis and treatment. We present a case of a 38-year-old male with progressive ascending bilateral lower extremity numbness and motor weakness in the presence of normal vitamin …

The Cultural Meaning In Ritual Traditions For The Character Of Osing People Banyuwangi, Indonesia, Imam Suyitno, Yuni Pratiwi, Kusubakti Andajani, Heni Dwi Arista Mrs.

The Qualitative Report

This study examined the cultural meaning of the ritual tradition for the character of the Osing people, Banyuwangi. The study focused on describing (a) the personal character in ritual tradition, (b) the social character in ritual traditions, and (c) the character values in ritual traditions. This study was qualitative research with the hermeneutic approach to interpret and explain the meaning of ritual tradition by involving three culturalists and community leaders as data resources. The study found that ritual tradition has cultural meaning for Osing people to build (a) personal character, which includes responsible, consistent, caring, sincere in their work, willing …