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Microbial Photodynamic Inactivation (Pdi) With Meso-Pyridyl Porphyrin Isomers Under Metabolic Gene Knockouts, Dylan Mavlyanov, Kenneth Supersano Apr 2026

Microbial Photodynamic Inactivation (Pdi) With Meso-Pyridyl Porphyrin Isomers Under Metabolic Gene Knockouts, Dylan Mavlyanov, Kenneth Supersano

Undergraduate Student Symposium

Photodynamic Inactivation (PDI) is an antimicrobial technique that functions independently of conventional antibiotic resistance by combining light, photosensitizers, and oxygen in order to eliminate pathogens. Drug-resistant microorganisms have long posed a global challenge, increasing the need for methods that prevent microbes from acquiring further immune adaptations. Photosensitizers serve as compounds that, upon light activation, generate reactive oxygen species (ROS) in order to induce microbial membrane damage and cell death, while also showing effects against cancerous mammalian cells. An investigation was conducted on three meso-Tetra(N-methyl-pyridyl) porphyrin tetrachloride isomers, examining their three conformations of nitrogen substitutions in both freebase and copper-metalated …

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Environmental Monitoring Of The Coral Nursery Lagoon At Peanut Island, Lindsay Scherer, Kamille Jackson, Madelyn Hooper, Briana Badowski, Nicole Mazhar Apr 2026

Environmental Monitoring Of The Coral Nursery Lagoon At Peanut Island, Lindsay Scherer, Kamille Jackson, Madelyn Hooper, Briana Badowski, Nicole Mazhar

Undergraduate Student Symposium

Temperature, dissolved oxygen (DO), salinity, and pH are critical abiotic factors influencing coral reef ecosystems. Enclosed lagoons, such as the one at Peanut Island, often experience reduced water exchange, making them prone to environmental fluctuations that may stress corals. The purpose of this project was to investigate potential correlations between water quality and coral health within the Peanut Island Coral Nursery Lagoon in Palm Beach County, Florida over a year-long period. Three Onset HOBO data loggers were deployed: U22-001 to measure temperature and pH; U26-001 to measure dissolved oxygen; and U24-002-C to measure salinity. The data loggers were deployed near …

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Red Mangrove Heavy Metal(Loid)S Accumulation In Contaminated Sediments Of The South Florida Intracoastal Waterway, Sophia Welch Apr 2026

Red Mangrove Heavy Metal(Loid)S Accumulation In Contaminated Sediments Of The South Florida Intracoastal Waterway, Sophia Welch

Undergraduate Student Symposium

Mangroves, recognized as hyperaccumulators, can tolerate and store high concentrations of heavy metal(loid)s without visible toxicity. While metal accumulation in mangroves has been extensively studied worldwide, data remain limited for North America, particularly in southeastern Florida, where urbanization and port activity increase contamination risk. This study quantified 16 heavy metal(loid)s in roots, branches, and leaves of red mangroves (Rhizophora mangle) and associated surface sediments collected across four sites within Dr. Von D. Mizell-Eula Johnson State Park at Port Everglades using inductively coupled plasma mass spectrometry (ICP-MS). Sediment samples were collected at distances of 0, 10, 50, and 100 …

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Hsc-3 Spheroid Enhances Macrophage Autophagy Through Upregulation Of Hgf Activator, Dhara Patel Apr 2026

Hsc-3 Spheroid Enhances Macrophage Autophagy Through Upregulation Of Hgf Activator, Dhara Patel

Undergraduate Student Symposium

Autophagy plays a critical role in regulating macrophage function within the tumor microenvironment. Hepatocyte growth factor activator (HGFA) can modulate autophagy-related pathways, potentially affecting macrophage function. This study aimed to test HGFA expression in oral cancer cell cultures and its effect on macrophage autophagy in a co-culture system. THP-1- derived macrophages were co-cultured with human oral cancer cells (HSC-3) in two-dimensional (2D) monolayers and three-dimensional (3D) spheroids generated using the hanging drop method. HGFA expression in HSC-3 cells was quantified by qPCR. After 72 hours of co-culture, macrophage polarization and autophagy were assessed by flow cytometry. To evaluate the functional …

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Nanomedicine-Based Modulation Of Parkinson's Disease Pathology Through Integrated Biological And Computational Approaches, Emma Hickey, Annu Joji, Abdallah Samarah, Larry Delgado, Parushi Porwal, Jonathan Tran, Jaashvi Chandagari Apr 2026

Nanomedicine-Based Modulation Of Parkinson's Disease Pathology Through Integrated Biological And Computational Approaches, Emma Hickey, Annu Joji, Abdallah Samarah, Larry Delgado, Parushi Porwal, Jonathan Tran, Jaashvi Chandagari

Undergraduate Student Symposium

Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopamine-producing neurons and the aggregation of α-synuclein, a protein that misfolds into neurotoxic fibrils. Current therapies primarily alleviate motor symptoms but do not slow disease progression, leaving PD pathology unaddressed. Biocompatible nanoparticles, known as carbon nanodots (CNDs), represent a promising therapeutic approach by penetrating the blood-brain barrier (BBB) and distrupting amyloid structures. Preclinical studies in zebrafish models of neurodegeneration have shown that our CNDs, developed by the LeBlanc Lab, reduce tau and amyloid-β aggregation, decrease neuroinflammation, and improve neuronal function, emphasizing their translational potential for PD. Here, …

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Consumerism Is The Perfection Of Slavery, Kashish Kirpalani Apr 2026

Consumerism Is The Perfection Of Slavery, Kashish Kirpalani

Undergraduate Student Symposium

In consumer capitalism, freedom is often defined through participation in the market where identity, financial stability, and happiness are tied to one's earning and spending. This paper examines how modern consumer culture restricts personal freedom by drawing on the ideas of Karl Marx, Herbert Marcuse, and Jean Baudrillard. These theorists explain how individuals become separated from their labor and from their own sense of purpose, creating dependence on systems that reward consumption. To connect these ideas to everyday life, the paper analyzes data from the National Election Studies. The results show that financial worry and recent financial hardship have the …

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Aging In Remote Waters: How Are Hawaiian Monk Seal Teeth Documenting Environmental Impacts?, Megan Martiello, Mason Schleicher, Ally Sheehan Apr 2026

Aging In Remote Waters: How Are Hawaiian Monk Seal Teeth Documenting Environmental Impacts?, Megan Martiello, Mason Schleicher, Ally Sheehan

Undergraduate Student Symposium

The Hawaiian Monk Seal (HMS) is the second most endangered pinniped species, and an apex predator endemic to the Hawaiian Archipelago. Majority of the population resides in the Northwest Hawaiian Islands which are divided into three regions for research purposes: Northern Hawaiian Island (NHI), Central Hawaiian Island (CHI), and Southern Hawaiian Island (SHI). This study analyzed long-term trace elements (TE) exposure in HMS by measuring 17 TEs (Ca, Cd, Co, Cr, Cu, Ba, Fe, Li, Mg, Mn, Mo, Ni, Pb, Sn, Sr, V, Zn) in cementum growth layer groupings (GLGs) of canine teeth using laser ablation induced coupled plasma mass …

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Assessing The Thermal Tolerance On Genotypic Variability In Acropora Cervicornis And Acropora Palmata Corals Maintained In An Offshore Nursery In Broward County, Florida, Luisa Maria Torres Arango Apr 2026

Assessing The Thermal Tolerance On Genotypic Variability In Acropora Cervicornis And Acropora Palmata Corals Maintained In An Offshore Nursery In Broward County, Florida, Luisa Maria Torres Arango

Undergraduate Student Symposium

Global warming and constant stressors are threatening the most diverse and abundant reef-building coral, causing their rapid decline. Elevations in ocean temperature have contributed to massive bleaching events and increased mortality in key coral species throughout Florida. The degradation of coral ecosystems not only reduces marine biodiversity but also threatens fisheries, coastal protections, and tourism that depend on healthy reef systems. In response, coral nursery programs have arisen as a conservation strategy for restoring reefs. Acropora species, particularly Acropora palmata and Acropora cervicornis, are among the most widely used corals in restoration due to their fast growth, large branching …

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Protecting Citrus Through Patents: Legal And Economic Implications Of Uf/Ifas Biotechnological Advances, Laeila Scott Apr 2026

Protecting Citrus Through Patents: Legal And Economic Implications Of Uf/Ifas Biotechnological Advances, Laeila Scott

Undergraduate Student Symposium

Citrus greening, or Huanglongbing (HLB), threatens the survival of Florida's citrus industry, driving innovation in disease-resistant crops through biotechnology. This research examines how intellectual property (IP) law shapes these advancements, focusing on the direct industry impact of the University of Florida's Institute of Food and Agricultural Sciences (UF/IFAS). Through analyzing patent strategies, licensing models, and governance structures, this study explores the balance between proprietary protections and public access. Additionally, it considers broader ethical and economic implications, including the challenges of patent enforcement and the impact on citrus growers. This research situates UF/IFAS's biotechnological innovations within the larger legal and economic …

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More Utilitarian Or Less Deontological? A Process Dissociation Approach, Kyle Fleming Apr 2026

More Utilitarian Or Less Deontological? A Process Dissociation Approach, Kyle Fleming

Undergraduate Student Symposium

It is well known in consumer behavior research that normatively equivalent tasks can elicit different preferences. Recent work has extended this finding to moral judgments, showing that matching tasks elicit stronger utilitarian preferences than choice or rating tasks. However, the processes driving these reversals remain unclear. According to the reflective utilitarian view, deeper processing increases utilitarian tendencies (i.e., the perceived importance of the outcome increases relative to the intrinsic moral value of the action). The intuitive deontologist view posits that deeper processing decreases deontological tendencies (i.e., the moral value of an action becomes less important). Finally, the reflective minimalist view …

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Understanding Atopic Dermatitis In East Asian Populations, Kaitlin Chao Apr 2026

Understanding Atopic Dermatitis In East Asian Populations, Kaitlin Chao

Undergraduate Student Symposium

Atopic dermatitis (AD) is a chronic inflammatory skin disorder driven by disrupted skin barriers and immune dysregulation. While much research has explored its mechanisms, most studies focus on generalized populations, overlooking critical ethnic differences. East Asian individuals, for example, experience a particularly high prevalence of AD, linked to unique genetic and immunologic patterns. Common FLG mutations in East Asians include R501X and c.3321delA; however, certain ethnic subgroups carry other variants, such as K4022X, S3296X, and S2889X, demonstrating how different mutations contribute to a range of atopic dermatitis severity. Immune analyses further reveal heightened Th17 and Th2 activation, elevated IgE levels, …

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A Civil War Of Screens: How Partisan Media Fractures American Democracy, Ava Khlopin Apr 2026

A Civil War Of Screens: How Partisan Media Fractures American Democracy, Ava Khlopin

Undergraduate Student Symposium

Political polarization in the United States has always consistently posed a fragile threat to democratic stability, as seen in historic timelines of the Civil War. With the rise of highly partisan media, these threats have rapidly increased over the past two decades, forcing ideological division and threatening our nation's unity once again. This research focuses on whether partisan media affects political polarization. The study utilizes the NES data set and incorporates Framing Theory, Selective Exposure Theory, and Participatory Media Theory to examine the relationship between exposure to a particular media stream and ideological extremity. The results indicate that viewers of …

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Low-Dose Atropine As A Therapeutic Intervention For Myopia Progression, Annabelle Chang Apr 2026

Low-Dose Atropine As A Therapeutic Intervention For Myopia Progression, Annabelle Chang

Undergraduate Student Symposium

The prevalence of myopia (nearsightedness) is growing at an increasingly alarming rate throughout the world. Data from 2010 measured myopia presence in the world's population to be 27% yet is predicted to reach 52% by 2050. One of the most common interventions implemented today is low dose atropine (0.01-0.05%) which acts upon muscarinic receptors in the back of the eye to slow eyeball elongation. The objective of this experiment is to examine the effectiveness of low dose atropine on slowing myopia progression in children by monitoring refractive error and axial length. It was hypothesized that low dose atropine will produce …

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Importance Of Patient-Provider Concordance And Sickle Cell Disease, Hamza Atiq Shaikh, Shivank Lattupally, Stavya Gupta Apr 2026

Importance Of Patient-Provider Concordance And Sickle Cell Disease, Hamza Atiq Shaikh, Shivank Lattupally, Stavya Gupta

Undergraduate Student Symposium

Sickle cell disease (SCD) is a hereditary blood disorder that affects millions of people worldwide and approximately 100,000 individuals in the United States, with a disproportionate impact on African American communities. The disease is characterized by abnormally shaped red blood cells that restrict blood flow, leading to chronic pain, organ damage, and reduced life expectancy. While medical advances such as hydroxyurea therapy, bone marrow transplantation, and emerging gene therapies have improved disease management, many patients continue to experience barriers in receiving effective and equitable care. One factor that may influence patient outcomes is patient-provider concordance, defined as shared characteristics such …

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Effects Of Reproductive Experience On Cognitive-Behavioral Outcomes In Mouse Models Of Alzheimer's Disease And Related Dementias, Chana Vogel, Esperanza Barrios, Ariana Hernandez, Natalia Noto Apr 2026

Effects Of Reproductive Experience On Cognitive-Behavioral Outcomes In Mouse Models Of Alzheimer's Disease And Related Dementias, Chana Vogel, Esperanza Barrios, Ariana Hernandez, Natalia Noto

Undergraduate Student Symposium

Alzheimer's disease and vascular dementia are devastating conditions lacking safe and effective treatments. Despite the striking sex difference in dementia's prevalence, few studies have investigated sex-specific factors that likely influence the greater risk and faster progression of disease in females: prior pregnancy and motherhood. Women with children experience slower rates of cognitive decline and lower risk of developing cognitive impairment than women with no children. However, other studies report mixed results, suggesting that the influence of reproductive experience could depend on an individual's number of children and/or their geographical location. Therefore, controlled studies in animal models are needed to determine …

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Artificial Intelligence Liability: Implications And Best Practices For Legal Professionals And Ai Developers, Alyssa Heinze Apr 2026

Artificial Intelligence Liability: Implications And Best Practices For Legal Professionals And Ai Developers, Alyssa Heinze

Undergraduate Student Symposium

The rapid integration of artificial intelligence into the legal profession has transformed legal research, drafting, and decision-making, while simultaneously introducing novel ethical, regulatory, and liability risks. As attorneys increasingly rely on generative AI systems, concerns surrounding hallucinations, bias, confidentiality breaches, and deceptive outputs have exposed both legal professionals and AI developers to heightened scrutiny. This presentation examines the current and emerging landscape of artificial intelligence liability in the United States, with particular attention to the absence of a comprehensive federal regulatory framework and the constitutional controversy surrounding Executive Order 14179 and its preemption of state AI legislation. By analyzing federal …

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Long Covid Analyzed: A Systematic Review Comparing Adults Affected By Long Covid To Adults Without Persistent Symptoms, Dev Patel Apr 2026

Long Covid Analyzed: A Systematic Review Comparing Adults Affected By Long Covid To Adults Without Persistent Symptoms, Dev Patel

Undergraduate Student Symposium

Over one-hundred million Americans were diagnosed with COVID-19, resulting in over one million deaths so far. Long COVID is defined as a chronic condition that presents a wide range of conditions occurring after SARS-CoV-2 infection and is present for at least three months. Since there is no definite test for Long Covid, many individuals may not know that they have this illness. Therefore, it is imperative within the Public Health field to synthesize current research to generate meaningful interventions and preventive practices. The research question is "What is the symptom spectrum like clusters, burden, for adults eighteen or older diagnosed …

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Addressing Co-Occurring Mental Illness In Adults With Autism Spectrum Disorder, Ella Riddle Apr 2026

Addressing Co-Occurring Mental Illness In Adults With Autism Spectrum Disorder, Ella Riddle

Undergraduate Student Symposium

Co-occurring mental health conditions are highly prevalent among adults with autism spectrum disorder (ASD) and represent a significant area of concern in adult mental health care. A 2014 study published in the Journal of Autism and Developmental Disorders reports that between 73%-81% of adults with ASD meet the criteria for at least one co-occurring mental illness (Buck et al., 2014). The national average of adults living with mental illness, as determined in 2022, is 23.1% (National Institute of Health, 2022). As these statistics illustrate, adults with ASD experience high rates of co-occurring mental illness, yet these conditions are often treated …

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Marine Mammal Bone As Recorder Of Trace Element Dynamics During The Past 5500 Years In The North Pacific Ocean, Aidan Pflieger Apr 2026

Marine Mammal Bone As Recorder Of Trace Element Dynamics During The Past 5500 Years In The North Pacific Ocean, Aidan Pflieger

Undergraduate Student Symposium

The North Pacific Ocean has been geologically dynamic and biologically diverse since the Last Glacial Maximum (20,000 ybp). Natural fluctuations in island arc volcanism and climate likely influence the input of essential and nonessential trace elements to the Aleutian Island Archipelago, even to present day. Accumulation of these elements in the region's marine food webs provides a measure of natural fluctuations in the environment. Ninety-eight samples of tephra-preserved marine mammal bone (primarily pinnipeds) sourced from temporally identified archeological Aleut midden sites on Unalaska Island (5500-200 ypb), were analyzed for 20 trace elements using inductively coupled plasma mass spectrometry (ICP-MS). Concentrations …

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The Impact Of Mouthwashes On Oral Microbiome Communities In University Students, Jinil Milind Shah, Simar Mathoun, Richa Rajesh, Hyungkyu Kim, Varsha Adabala, Chelsea Borja, Rhianna Jacob, Trisha Jois, Jordan Monteiro, Noura Naami Apr 2026

The Impact Of Mouthwashes On Oral Microbiome Communities In University Students, Jinil Milind Shah, Simar Mathoun, Richa Rajesh, Hyungkyu Kim, Varsha Adabala, Chelsea Borja, Rhianna Jacob, Trisha Jois, Jordan Monteiro, Noura Naami

Undergraduate Student Symposium

The oral cavity hosts a complex microbial ecosystem, which can be altered due to physical or chemical exposures, such as dental mouthwashes. This study examined the short-term impact of two commonly used Listerine mouthwashes, alcohol-containing and alcohol-free, compared to water (as control) on the oral microbiome and salivary pH in a college student population. Oral swab samples were collected after the oral rinse and salivary pH measurements were obtained to assess immediate biochemical changes. Microbial DNA was extracted and the V4 region of the 16S rRNA gene was amplified using PCR. Sequencing was performed on an Illumina MiSeq platform, producing …

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Identifying Biomarkers Indicative Of Active And Passive Exposure To Electronic Cigarette Aerosols, Armaan Makwana, Om Patel, Suhani Makwana, Chelsea Nguyen Apr 2026

Identifying Biomarkers Indicative Of Active And Passive Exposure To Electronic Cigarette Aerosols, Armaan Makwana, Om Patel, Suhani Makwana, Chelsea Nguyen

Undergraduate Student Symposium

Electronic cigarettes (e-cigarettes) have grown in popularity as they are portrayed as a healthier alternative to conventional cigarettes. However, recent studies have identified the presence of toxic chemicals in e-cigarettes liquids and their aerosols. While active users of e-cigarettes (AE) are directly exposed to these chemicals, little is known about the extent of exposure in non-users who are passively exposed (PE) to e-cigarette aerosols. In this study, we analyzed saliva samples from active users and non-users who are either passively exposed (those who live or work with an active user) or not exposed to e-cigarette aerosols to determine whether their …

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Exploring The Presence Of Persistent Organic Pollutants (Pops) In The Muscle Tissue Of Various Alaskan Salmon Species, Sara Simonetti, Victoria Angelini, Vanessa Miro Apr 2026

Exploring The Presence Of Persistent Organic Pollutants (Pops) In The Muscle Tissue Of Various Alaskan Salmon Species, Sara Simonetti, Victoria Angelini, Vanessa Miro

Undergraduate Student Symposium

Alaska supplies 60% of the fish consumed in the United States; therefore, determining the presence of persistent organic pollutants (POPs) in fish sourced from that area is critical. POPs are chemical compounds that are classified as one of 209 congeners of either polychlorinated biphenyls (PCBs) or polybrominated diphenyl ethers (PBDEs). They resist degradation and contribute to a range of harmful effects to both humans and wildlife, such as cancers and birth defects. Their introduction into the environment stemmed from their industrial and agricultural usage. However, despite being banned by the Stockholm Convention in 2004, they continue to be present in …

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Assessing Sediment Composition, Organic Matter, Metal Contamination, And Ecological Risks In Port Everglades, Florida, Elisa Prodhomme, Gabrielle Spankus Apr 2026

Assessing Sediment Composition, Organic Matter, Metal Contamination, And Ecological Risks In Port Everglades, Florida, Elisa Prodhomme, Gabrielle Spankus

Undergraduate Student Symposium

Port sediments often accumulate heavy metals and organic pollutants from anthropogenic inputs. The planned expansion of Port Everglades (Fort Lauderdale, Florida, USA) raises concern that dredging may remobilize contaminated sediments, potentially affecting nearby benthic habitats, including coral reefs. To assess sediment quality, eighteen cores were collected from five port sites and one control site, along with additional surface sediments. Cores were sectioned at 10 cm intervals and analyzed for 14 metals (ICP-MS), percent organic matter, and grain size. Geo-accumulation index results indicated moderate to strong contamination by As and Mo, while ecological risk assessments suggested moderate to high overall metal …

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Comparative Profiling Of Persistent Organic Pollutants In Alaskan Pink Salmon Roe And Muscle Tissue (Oncorhynchus Gorbuscha), Aleena Thomas, Megan Bailey, Luisa Torres Apr 2026

Comparative Profiling Of Persistent Organic Pollutants In Alaskan Pink Salmon Roe And Muscle Tissue (Oncorhynchus Gorbuscha), Aleena Thomas, Megan Bailey, Luisa Torres

Undergraduate Student Symposium

Persistent organic pollutants (POPs) are toxins that bioaccumulate through food chains--especially in marine ecosystems. They are primarily classified as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), each with 209 congeners associated with adverse human health outcomes such as cancer. Despite bans placed during the 2004 Stockholm Convention on Persistent Organic Pollutants, POP concentrations have remained consistent. Alaskan pink salmon (Oncorhynchus gorbuscha) are integral to Southeast Alaskan River ecosystems as a major food source for humans and animals. Detecting POPs in roe provides evidence of maternal offloading, indicating that these pollutants persist across life stages and generations. Salmon …

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Endoparasites In Magnificent Frigatebirds (Fregata Magnificens Rothschildi) From Southeast Florida, Usa, Isabelle Petty, Alexia Hilber Apr 2026

Endoparasites In Magnificent Frigatebirds (Fregata Magnificens Rothschildi) From Southeast Florida, Usa, Isabelle Petty, Alexia Hilber

Undergraduate Student Symposium

The Magnificent Frigatebird (Fregata magnificens) is a pelagic seabird widely distributed across tropical and subtropical regions. Due to its wide-ranging foraging behavior and fish-based diet, these birds are susceptible to parasitic infections. However, little is known about the species' endoparasite communities. Despite its ecological importance, research on this species remained limited, particularly regarding the diversity and distribution of endoparasites. This study aims to investigate the endoparasite community in these birds. Specimens were collected from multiple rehabilitation centers from southeast Florida. A total of six individuals were examined (MAFR 2000, 3105, 3106, 3107, 3108, and 3109) for parasite presence …

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Modeling The Disruption Of Binding Of Three Ige Antibodies With Six Mutated Interaction Sites On The Arah2 Allergen, Amaan Khan, Hansi Parmar, Jyothi Vivekananda Apr 2026

Modeling The Disruption Of Binding Of Three Ige Antibodies With Six Mutated Interaction Sites On The Arah2 Allergen, Amaan Khan, Hansi Parmar, Jyothi Vivekananda

Undergraduate Student Symposium

Peanut allergy is a life-threatening food allergy that affects millions of children and adults across the world. This issue presents serious public health concerns and heavy interest from the scientific community to find viable treatments that minimize immunological side effects. To better understand and explain the peanut allergy response, the literature was examined, and a 3D model was printed based on two protein database files. Arachis hypogaea 2 (Arah2) is the dominant peanut allergen protein. When Arah2 binds IgE antibodies, a strong allergic response is triggered. This reaction makes treating allergy patients with Oral Immunotherapy (OIT) difficult due to adverse …

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Disrupting Stat3 Signaling In Glioblastoma Stem Cells Using Nitro-Modified Curcumin Analogs, Sneha Subhash, Swara Chindhade, Maria Moreno Hollweg, Kyuree Chang Apr 2026

Disrupting Stat3 Signaling In Glioblastoma Stem Cells Using Nitro-Modified Curcumin Analogs, Sneha Subhash, Swara Chindhade, Maria Moreno Hollweg, Kyuree Chang

Undergraduate Student Symposium

Signal Transducer and Activator of Transcription 3 (STAT3) is frequently overactivated in cancers, including glioblastoma (GBM), where its dysregulation is associated with aggressive disease and poor patient survival. STAT3 supports tumor progression by promoting proliferation, resistance to apoptosis, maintenance of cancer stem cells, and immune suppression. Although numerous STAT3 inhibitors are under preclinical and clinical evaluation, none have yet achieved FDA approval. GBM remains a highly lethal brain cancer with limited therapeutic options, underscoring the need for new targeted treatments. Nitro-containing compounds, known for their strong electron-withdrawing characteristics, are emerging as potential anticancer agents. A library of 41 nitro-containing chalcones …

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Ticked Off: A Systematic Review Of Alpha-Gal Syndrome Mechanisms Apr 2026

Ticked Off: A Systematic Review Of Alpha-Gal Syndrome Mechanisms

Undergraduate Student Symposium

Alpha-gal syndrome is characterized by an IgE-mediated immune response against galactose-α-1,3-galactose. In the United States, the principal vector is the Lone Star tick, whose range has expanded nationwide. 110,000 cases have been reported since 2010, with the CDC estimating 450,000 as many cases go unrecognized. Vomiting, difficulty breathing, and hypotension can occur immediately or hours after exposure. Ongoing exposure to alpha galactose with AGS increases mast cell inflammatory response, raising coronary artery disease risk. Perioperative ingredients like gelatin, monoclonal antibodies, and stearic acid have triggered anaphylactic shock in AGS patients. These complications hinder diagnosis. The inclusion criteria required original research …

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Snapping Shrimp Acoustic Activity As An Indicator Of Ecosystem Health Across Mangrove, Seagrass, And Coral Reef Habitats In The Florida Keys, Catherine Salazar, Alexander Wheeler Apr 2026

Snapping Shrimp Acoustic Activity As An Indicator Of Ecosystem Health Across Mangrove, Seagrass, And Coral Reef Habitats In The Florida Keys, Catherine Salazar, Alexander Wheeler

Undergraduate Student Symposium

Mangroves, coral reefs, and seagrass provide refugia, nursery areas, and feeding grounds for many marine species. These ecosystems have faced declines in habitat complexity through natural and anthropogenic causes. Passive acoustic monitoring (PAM) is used to track changes in habitat characteristics through the monitoring of acoustic species, like snapping shrimp. Snapping shrimp are among the most active species inhabiting shallow subtropical marine environments, and their abundance, often tracked through their acoustic activity, are strong indicators of a healthy ecosystem. This study compares the acoustic activity of snapping shrimp across mangrove, seagrass, and coral reef habitats in Key Largo, Florida, as …

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Sold For Parts: Moral Connections Between Paid Surrogacy And Paid Organ Donation, Alessandra Coke Apr 2026

Sold For Parts: Moral Connections Between Paid Surrogacy And Paid Organ Donation, Alessandra Coke

Undergraduate Student Symposium

Throughout this presentation, I make ethical arguments about paid surrogacy, based on established arguments regarding paid living organ donation possible due to similarities between the procedures. I establish the differences between conceptualizations of surrogacy: unpaid/altruistic and paid/compensated, and clarify what is meant by paid surrogacy. The primary similarity between paid living organ donation and paid surrogacy is that both practices are a 'voluntary' violation of bodily integrity for financial benefit. I argue that both practices due to financial incentives cannot truly be seen as voluntary. I argue that the reasons that are used to understand paid living organ donation as …

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