Digital Commons Network^™

Reimagining Supportive Approaches At The Intersection Of Mandatory Reporting Policies For The Mother–Infant Dyad Affected By Substance Use, Kelly Mcglothen-Bell, Diana Cartagena, Kathryn J. Malin, Dorothy Vittner, Jacqueline M. Mcgrath, Rebecca Koerner, Ashlee J. Vance, Allison Crawford

College of Nursing Faculty Research and Publications

Background: As rates of substance use during pregnancy persist, the health and optimal development of infants with prenatal substance exposure remain a key priority. Nurses are tasked with identifying and reporting suspected cases of child maltreatment, including abuse and neglect, which is often assumed to be synonymous with substance use during pregnancy. While policies aimed at protecting infants from child abuse and neglect are well intentioned, literature regarding the short- and long-term social and legal implications of mandatory reporting policies is emerging.

Purpose: In this article, we explore the intersections between the condition of substance use in pregnancy and policies …

Thinking Through How Race, Disability, And Gender Work Together, Rosemarie Garland-Thomson, Desiree Valentine

Philosophy Faculty Research and Publications

No abstract provided.

The Middle Domain Of Hsp104 Can Ensure Substrates Are Functional After Processing, Hannah Buchholz, Jane E. Dorweiler, Sam Guereca, Brett T. Wisniewski, James Shorter, Anita L. Manogaran

Biological Sciences Faculty Research and Publications

Molecular chaperones play a central role in protein disaggregation. However, the molecular determinants that regulate this process are poorly understood. Hsp104 is an AAA+ ATPase that disassembles stress granules and amyloids in yeast through collaboration with Hsp70 and Hsp40. In vitro studies show that Hsp104 processes different types of protein aggregates by partially translocating or threading polypeptides through the central pore of the hexamer. However, it is unclear how Hsp104 processing influences client protein function in vivo. The middle domain (MD) of Hsp104 regulates ATPase activity and interactions with Hsp70. Here, we tested how MD variants, Hsp104^A503S and …

Morphology Of The Normative Human Cone Photoreceptor Mosaic And A Publicly Available Adaptive Optics Montage Repository, Robert F. Cooper, Snega Kalaparambath, Geoffrey K. Aguirre, Jessica I. W. Morgan

Biomedical Engineering Faculty Research and Publications

Adaptive optics ophthalmoscopy has enabled visualization of the in vivo human photoreceptor mosaic in health, disease and its treatment. Despite this, the clinical utility of the imaging technology has been limited by a lack of automated analysis techniques capable of accurately quantifying photoreceptor structure and a lack of an available normative image database. Here, we present a fully automated algorithm for estimating cone spacing and density over a complete adaptive optics montage along with a database of normative images and cone densities. We imaged the cone mosaics surrounding the fovea and along the horizontal and vertical meridians of fifty normal-sighted …

Behind Armor Blunt Trauma: Liver Injuries Using A Live Animal Model, Narayan Yoganandan, Alok Shah, Brian D. Stemper, Lewis Somber, Valeta Carol Chancey, Joseph Mcentire

Biomedical Engineering Faculty Research and Publications

Introduction

While the 44-mm clay penetration criterion was developed in the 1970s for soft body armor applications, and the researchers acknowledged the need to conduct additional tests, the same behind the armor blunt trauma displacement limit is used for both soft and hard body armor evaluations and design considerations. Because the human thoraco-abdominal contents are heterogeneous, have different skeletal coverage, and have different functional requirements, the same level of penetration limit does not imply the same level of protection. It is important to determine the regional responses of different thoraco-abdominal organs to better describe human tolerance and improve the current …

Enhanced Perfluorooctanoic Acid (Pfoa) Degradation By Electrochemical Activation Of Peroxydisulfate (Pds) During Electrooxidation For Water Treatment, Melvin S. Samuel, Kadarkarai Govindan, Donald R. Ryan, Sean T. Mcbeath, Brooke K. Mayer, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Improved treatment of per- and polyfluoroalkyl substances (PFAS) in water is critically important in light of the proposed United States Environmental Protection Agency (USEPA) drinking water regulations at ng L−1 levels. The addition of peroxymonosulfate (PMS) during electrooxidation (EO) can remove and destroy PFAS, but ng L−1 levels have not been tested, and PMS itself can be toxic. The objective of this research was to test peroxydisulfate (PDS, an alternative to PMS) activation by boron-doped diamond (BDD) electrodes for perfluorooctanoic acid (PFOA) degradation. The influence of PDS concentration, temperature, and environmental water matrix effects, and PFOA concentration on PDS-EO …

Consequences Of Local Conspecific Density Effects For Plant Diversity And Community Dynamics, Joseph A. Lamanna, Stefan A. Schnitzer

Biological Sciences Faculty Research and Publications

Conspecific density dependence (CDD) in plant populations is widespread, most likely caused by local-scale biotic interactions, and has potentially important implications for biodiversity, community composition, and ecosystem processes. However, progress in this important area of ecology has been hindered by differing viewpoints on CDD across subfields in ecology, lack of synthesis across CDD-related frameworks, and misunderstandings about how empirical measurements of local CDD fit within the context of broader ecological theories on community assembly and diversity maintenance. Here, we propose a conceptual synthesis of local-scale CDD and its causes, including species-specific antagonistic and mutualistic interactions. First, we compare and clarify …

Altered Cortical Activity During A Finger Tap In People With Stroke, Priya Balasubramanian, Roxanne P. Deleon, Dylan B. Snyder, Scott A. Beardsley, Allison S. Hyngstrom, Brian D. Schmit

Biomedical Engineering Faculty Research and Publications

This study describes electroencephalography (EEG) measurements during a simple finger movement in people with stroke to understand how temporal patterns of cortical activation and network connectivity align with prolonged muscle contraction at the end of a task. We investigated changes in the EEG temporal patterns in the beta band (13–26 Hz) of people with chronic stroke (N = 10, 7 F/3 M) and controls (N = 10, 7 F/3 M), during and after a cued movement of the index finger. We quantified the change in beta band EEG power relative to baseline as activation at each electrode and …

The Myth Of The Alpha Wolf, Prairie Kidd

Affirmation/Transformation: Fandom Created

Prairie Kidd
The Myth of the Alpha Wolf, 2024
Fandom: Omegaverse
Audio Essay
N/A
Collection of the creator

Rating: Mature
Tags: omegaverse, alpha male, beta male, omega, knotting, breeding, mlm, gay stuff, academic gay stuff, a/b/o

Creator's Notes: The understanding of human sexuality can often be understood through other animals. In the 70s, a researcher concluded that wolves work in packs, naming one as the Alpha, or top dog. The other wolves were given, thus, a classification under the Greek alphabet to represent their rank, and sexual status. This idea was so pronounced that it made its way into …

Translational Approaches To The Neurobiological Study Of Conditional Discrimination And Inhibition: Implications For Psychiatric Disease, Susan Sangha, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

There is a growing number of studies investigating discriminatory fear conditioning and conditioned inhibition of fear to assess safety learning, in addition to extinction of cued fear. Despite all of these paradigms resulting in a reduction in fear expression, there are nuanced differences among them, which could be mediated through distinct behavioral and neural mechanisms. These differences could impact how we approach potential treatment options in clinical disorders with dysregulated fear responses. The objective of this review is to give an overview of the conditional discrimination and inhibition findings reported in both animal models and human neuropsychiatric disorders. Both behavioral …

Penetration Thresholds Of Porcine Limbs For Low Sectional Density Projectiles In High-Rate Impact, Joseph Lesueur, Jared Michael Koser, Carolyn E. Hampton, Michael Kleinberger, Frank A. Pintar

Biomedical Engineering Faculty Research and Publications

Introduction

With similar prevalence to injuries from fires, stings, and natural disasters, soft tissue injuries may occur from fireworks, industrial accidents, or other explosives. Surgeons are less familiar with treating high-velocity penetration from small debris, which may increase the chance of infection and subsequent fatality. Penetration risk curves have been developed to predict V₅₀, the velocity with 50% probability of penetration, for various sized projectiles. However, there has been limited research using nonmetallic materials to achieve lower density projectiles less than 1 g cm−2, such as sand or rocks.

Material and Methods

To emulate the size and density …

Racial Discrimination Increases The Risk For Nonremitting Posttraumatic Stress Disorder Symptoms In Traumatically Injured Black Individuals Living In The United States, Lucas Torres, Timothy J. Geier, Carissa W. Tomas, Claire M. Bird, Sydney Clare Timmer-Murillo, Christine L. Larson, Terri A. Deroon-Cassini

Psychology Faculty Research and Publications

Traumatic, life-threatening events are experienced commonly among the general U.S. population, yet Black individuals in the United States (i.e., Black Americans) exhibit higher prevalence rates of posttraumatic stress disorder (PTSD) and more severe symptoms than other populations. Although empirical research has noted a range of symptom patterns that follow traumatic injury, minimal work has examined the role of racial discrimination in relation to PTSD symptom trajectories. The current study assessed racial discrimination and PTSD symptom trajectories at 6 months postinjury across two separate samples of traumatically injured Black Americans (i.e. emergency department (ED)–discharged and hospitalized). Identified PTSD symptom trajectories largely …

“It Is Like A Curse”. The Lived Experiences Of The Intersection Of Intergenerational Violence, Pregnancy, And Intimate Partner Violence Among Urban Wisconsin Indigenous Women, Jeneile Luebke, Nicole Thomas, Yamikani B. Nkhoma, Angela R. Fernandez, Kaylen M. Moore, Alexa A. Lopez, Lucy Mkandawire-Valhmu

College of Nursing Faculty Research and Publications

Background

Intimate Partner Violence (IPV) is a significant public health concern that disproportionately impacts Indigenous American women more than any other ethnic/racial group in the United States.

Purpose

This study aims to inform the work of nurses and allied health professionals by providing insight into the lived realities of Indigenous women in urban areas and how IPV manifests in the lives of Indigenous women.

Methods

Postcolonial and Indigenous feminist frameworks informed this qualitative study. Using thematic analysis, we analyzed data from semi-structured individual interviews with 34 Indigenous women in large urban areas in the upper Midwest.

Findings

This manuscript discusses …

Context-Aware Self-Supervised Learning Of Whole Slide Images, Milam Aryal, Nasim Yahyasoltani

Computer Science Faculty Research and Publications

Presenting whole slide images (WSIs) as graph will enable a more efficient and accurate learning framework for cancer diagnosis. Due to the fact that a single WSI consists of billions of pixels and there is a lack of vast annotated datasets required for computational pathology, the problem of learning from WSIs using typical deep learning approaches such as convolutional neural network (CNN) is challenging. Additionally, WSIs downsampling may lead to the loss of data that is essential for cancer detection. A novel two-stage learning technique is presented in this work. Since context, such as topological features in the tumor surroundings, …

Synthetic And Mechanistic Studies Of Ruthenium Catalyzed C–N And C–H Bond Activation Reactions, Krishna Prasad Gnyawali

Dissertations (1934 -)

Transition metal catalyzed C–H and C–N functionalization methods have emerged as an innovative tool for designing efficient synthesis of fine chemicals by using readily available starting materials without the formation of wasteful byproducts. One of the paramount challenges in C–H functionalization research field has been to promote regio- and stereoselective C–H bond activation on saturated hydrocarbon substrates. While much progress has been achieved on promoting selective sp2 C–H activation reactions on unsaturated hydrocarbon substrates in the past decades, catalytic sp3 C–H bond and functionalization methods on saturates hydrocarbon substrates remain as the frontier topic of C–H functionalization research. The well-defined …

Effects Of Posttraumatic Cognitions, Working Alliance, And Relational Intimacy Skills In Ptsd Treatment, Xiaonan Zhang

Dissertations (1934 -)

Cognitive theories have been proposed to explain the development and maintenance of posttraumatic stress disorder (PTSD). Social-cognitive theories, as one of two major categories of cognitive theories (Brewin et al., 1996), emphasize the role of trauma-related beliefs in the development of PTSD, which led to the incorporation of modifying maladaptive trauma-related cognitions in psychological treatments of PTSD. Although extant studies have provided empirical evidence for the efficacy of these treatments, questions regarding active therapeutic components still exist. To that end, this study examined the effects of social-cognitive factors (i.e., posttraumatic cognitions, relational intimacy skills, and working alliance) on PTSD symptomatology …

Closing The Phosphorus Loop With Green Infrastructure: Removal And Recovery Using Amended Soils And 3d-Printed Material, Colin Wilson

Dissertations (1934 -)

Phosphorus (P) is a life-essential element aiding the deterioration of water quality. Stormwater runoff transports nonpoint source P pollution to waterbodies, contributing to excessive P loading which may result in eutrophication. Green infrastructure (GI) is implemented to solve stormwater runoff pollution, but the P removal performance of these systems is variable. Moreover, P is arguably being unsustainably mined for fertilizer production and animal feed supplements to support demand from increasing global populations. This dissertation explored advancing the circular P economy utilizing additive manufacturing and GI soil amendments to remove and recover P from stormwater runoff. Laboratory-scale batch experiments were used …

Precision Deuteration And Hydrofunctionalization Of Aryl Alkynes And Alkenes, Samantha E. Sloane

Dissertations (1934 -)

The similar nature of the hydrogen atom to its isotope, deuterium, allows for the simple exchange of hydrogen atoms for deuterium atoms in drug molecules to alter the absorption, distribution, metabolism, and excretion properties. Installing the deuterium functionality into a specific site in the molecule is essential. Selective hydrofunctionalization reactions of alkynes and alkenes using the highly reactive catalytic Cu–H species have been well developed, and synthetic organic chemistry methods to selectively incorporate one or two deuterium atoms into the benzylic site of organic compounds, a key metabolic position, are elusive. A Cu–H catalytic approach offers selectivity and reactivity to …

Understanding Foster Parents' Experiences Of Secondary Traumatic Stress, Sarah Marie Boeding

Dissertations (1934 -)

Secondary traumatic stress, which has been studied across many helping professions, refers to symptoms similar to posttraumatic stress disorder which an individual may develop as a result of indirect exposure to another individual’s trauma (Sprang et al., 2019). Foster parents may be particularly susceptible to developing secondary traumatic stress due to their exposure to their foster child’s trauma history and trauma symptoms, which has been confirmed in recent studies (Bridger et al., 2020; Whitt-Woosley et al., 2020). Importantly, foster parents’ experiences of secondary traumatic stress may differ from those of other helping professionals given their unique role. The purpose of …

Deep Machine Learning Algorithms For Hvac Energy Usage And Cost Optimization In Smart Grids, Rahman Heidarykiany

Dissertations (1934 -)

This dissertation investigates the application of advanced machine learning (ML) and optimization methods to enhance the efficiency and cost-effectiveness of heating, ventilation, and air conditioning (HVAC) systems in smart homes. The research is structured into three main chapters, each addressing different aspects of energy management through innovative technologies and strategies. The first part focuses on improving electrical energy demand forecasting using long short-term memory (LSTM) models. It examines the impact of various model parameters on forecasting accuracy, finding that certain configurations can significantly enhance model performance measured as model accuracy. The research identifies optimal model settings, including layer numbers and …

Mechanisms Of Fatigability In Individuals With Prediabetes And The Effect Of Dietary Nitrate Supplementation, Blaine Evan Arney

Dissertations (1934 -)

Prediabetes is characterized as elevated blood glucose levels below the clinical threshold for type 2 diabetes. Previous research identified an increased fatigability (exercise-induced reduction in limb force or power) of the lower limb muscles in individuals with prediabetes which can impair physical function and lead to reduced physical activity. The mechanisms of fatigability in people with prediabetes are not known but are likely related to suggested vascular dysfunction in prediabetes. An important healthcare goal is to determine effective treatments to offset the increased fatigability in people with prediabetes to improve daily function. The purpose of this dissertation was to determine …

Childhood Maltreatment And Amygdala-Mediated Anxiety And Posttraumatic Stress Following Adult Trauma, Farah Harb, Michael T. Liuzzi, Ashley A. Huggins, E. Kate Webb, Jacklynn M. Fitzgerald, Jessica L. Krukowski, Terri A. Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Background

Childhood abuse (physical, emotional, and sexual) is associated with aberrant connectivity of the amygdala, a key threat-processing region. Heightened amygdala activity also predicts adult anxiety and posttraumatic stress disorder (PTSD) symptoms, as do experiences of childhood abuse. The current study explored whether amygdala resting-state functional connectivity may explain the relationship between childhood abuse and anxiety and PTSD symptoms following trauma exposure in adults.

Methods

Two weeks posttrauma, adult trauma survivors (n = 152, mean age [SD] = 32.61 [10.35] years; women = 57.2%) completed the Childhood Trauma Questionnaire and underwent resting-state functional magnetic resonance imaging. PTSD and anxiety …

Time-Restricted Feeding Reveals A Role For Neural Respiratory Clocks In Optimizing Daily Ventilatory-Metabolic Coupling In Mice, Aaron A. Jones, Gabriella M. Marino, Deanna M. Arble

Biological Sciences Faculty Research and Publications

The master circadian clock, located in the suprachiasmatic nuclei (SCN), organizes the daily rhythm in minute ventilation (V̇e). However, the extent that the daily rhythm in V̇e is secondary to SCN-imposed O2 and CO2 cycles (i.e., metabolic rate) or driven by other clock mechanisms remains unknown. Here, we experimentally shifted metabolic rate using time-restricted feeding (without affecting light-induced synchronization of the SCN) to determine the influence of metabolic rate in orchestrating the daily V̇e rhythm. Mice eating predominantly at night exhibited robust daily rhythms in O2 consumption (V̇o2), CO2 production (V̇co2), and V̇e with similar peak times (approximately ZT18) that …

Orthodontic Load Quantification Leveling A Deep Curve Of Spee With Different Archwire Designs, Ahmed Youssef

Master's Theses (2009 -)

Objective: This study aimed to quantify the effects of different materials, sizes of the continuous archwires in leveling the exaggerated curve of Spee. We used an orthodontic force tester apparatus to measure the forces and moments delivered by the archwires to the brackets attached to the sensors of one quadrant of the arch (from 1st incisor to 2nd molar). The hypothesis is that there is no difference in the load and moments between the incisors when the curve of Spee is leveled with the three different mechanical designs being tested. Methods: An orthodontic force tester (OFT) was used to measure …

The Role Of Obesity In The Development Of Disordered Breathing, Sarah N. Framnes-Deboer

Master's Theses (2009 -)

Obesity is a complex disease that is defined by an excess amount of body fat. Obesity can have physical, neurological, and endocrine effects and detrimental effects on health. Some obese co-morbid conditions, such as type 2 diabetes have known mechanisms, while others, such as sleep disordered breathing do not. Moreover, there are common respiratory diseases associated with obesity, such as obstructive sleep apnea and obesity hypoventilation syndrome. Furthermore, individuals with obesity or obstructive sleep apnea have a blunted hypercapnic ventilatory response (HCVR) (120), which is indicative of impaired chemosensitivity, as HCVR is a measure of how well an individual responds …

A Guide To Understanding Big Data For The Nurse Scientist: A Discursive Paper, Henry Ofori Duah, Samantha J. Boch, Sara Arter, Nichole Nidey, Joshua Lambert

College of Nursing Faculty Research and Publications

Big data refers to extremely large data generated at high volume, velocity, variety, and veracity. The nurse scientist is uniquely positioned to leverage big data to suggest novel hypotheses on patient care and the healthcare system. The purpose of this paper is to provide an introductory guide to understanding the use and capability of big data for nurse scientists. Herein, we discuss the practical, ethical, social, and educational implications of using big data in nursing research. Some practical challenges with the use of big data include data accessibility, data quality, missing data, variable data standards, fragmentation of health data, and …

Sharps Injuries Among Healthcare Workers In Liberia And Ghana: A Cross-Sectional Survey, Laura Jean Ridge, John Arko-Mensah, Josh Lambert, Lydia Aziato, G. Clinton Zeantoe, Henry Ofori Duah, Marjorie Mccullagh

College of Nursing Faculty Research and Publications

There are little data on sharps injuries among healthcare workers in West Africa despite the region’s high rate of hepatitis B and human immunodeficiency virus. The purpose of this study is to investigate healthcare workers’ history of sharps injuries in Liberia and Ghana. An electronic cross-sectional survey was conducted among healthcare workers in Liberia and Ghana from February to June 2022. A link to the survey was texted to participants through professional association membership lists, including nursing, midwifery, and physician assistant organizations in both Liberia and Ghana and a physician organization in Ghana only. Five hundred and nine participants reported …

Sex Differences In Spontaneous Respiratory Recovery In Chronic Hemisection, Taylor C. Holmes, Nicole M. Popp, Carley F. Hintz, Isabell Dobrzycki, Carolyn J. Schmitz, Kaylyn A. Schwichtenberg, Elisa J. Gonzalez-Rothi, Christopher W. Sundberg, Kristi A. Streeter

Physical Therapy Faculty Research and Publications

Respiratory deficits after C2 hemisection (C2Hx) have been well documented through single-sex investigations. Although ovarian sex hormones enable enhanced respiratory recovery observed in females 2 wk post-C2Hx, it remains unknown if sex impacts spontaneous respiratory recovery at chronic time points. We conducted a longitudinal study to provide a comprehensive sex-based characterization of respiratory neuromuscular recovery for 8 wk after C2Hx. We recorded ventilation and chronic diaphragm electromyography (EMG) output in awake, behaving animals, phrenic motor output in anesthetized animals, and performed diaphragm muscle histology in chronically injured male and female rodents. Our results show that females expressed a greater recovery …

Noninvasive Estimation Of Skeletal Muscle Oxygen Consumption Rate And Microvascular Reactivity In Chronic Stroke Survivors Using Near-Infrared Spectroscopy, Allison S. Hyngstrom, Jennifer N. Nguyen, David D. Gutterman, Brian D. Schmit, Emilie A. Klevenow, Matthew J. Durand

Physical Therapy Faculty Research and Publications

Understanding post-stroke changes in skeletal muscle oxidative metabolism and microvascular reactivity could help create therapeutic targets that optimize rehabilitative interventions. Due to disuse atrophy, we hypothesized that basal muscle oxygen consumption rate and microvascular endothelial function would be impaired in the tibialis anterior (TA) muscle of the affected leg of chronic stroke survivors compared with the nonaffected leg and versus matched controls. Fifteen chronic stroke survivors (10 females) and 15 matched controls (9 females) completed this study. A near-infrared spectroscopy oximeter measured tissue oxygen saturation (StO₂) of the TA in both legs of stroke survivors and the dominant …

Relationship Between Heart Rate Variability And Differential Patterns Of Cortisol Response To Acute Stressors In Mid-Life Adults: A Data-Driven Investigation, Meghan M. Bennett, Carissa W. Tomas, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Cortisol and heart rate variability (HRV) are well‐established biomarkers of the human stress response system. While a relationship between cortisol and HRV is assumed, few studies have found evidence of their correlation within single study designs. One complication for isolating such a relationship may lie in individual variability in the cortisol response to stress such that atypical cortisol responding (i.e., elevated or blunted) occurs. To‐date, studies on the cortisol response have employed traditional mean‐difference‐based approaches to examine average magnitude change in cortisol over time. Alternatively, data‐driven trajectory modelling, such as latent growth mixture modelling, may be advantageous for quantifying cortisol …