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Gumbo Yearbook, Class Of 2025, Louisiana State University And Agricultural And Mechanical College

Gumbo Yearbook

The Gumbo yearbook chronicles the entire academic year at LSU. In words and especially photos, the Gumbo shows the people, places, and events that make each year unique. In addition to formal portraits of schools and departments, the book contains hundreds of snapshots of students with their friends and dozens of pages showcasing organizations.

A Network Analysis Of Social Determinants Of Health And Youth Suicidal Ideation And Suicide Attempts At The Neighborhood-Level In Houston, Tx, Tyler Hendley

LSU Master's Theses

Youth suicide is a complex, multi-faceted human phenomenon that has no singular cause but instead is theorized to be a result of an interplay of psychological, biological, and social risk and protective factors. To best identify youth suicide risk and possible avenues for intervention, a social-ecological model approach may prove beneficial. As community-level risk factors (i.e., social determinants of health (SDOH)) have shown to impact health outcomes, it is important to understand the association between community-level risk and youth suicide-related behaviors. Utilizing a network analytic approach, this study developed an estimated partial correlation network to understand the relationship between youth …

Physics-Informed Heterogeneous Spatiotemporal Graph Neural Network For Reservoir Simulation, Ahmed A.M.A. Abdullah

LSU Master's Theses

Reservoir simulation is the state-of-the-art method for predicting the flow of petroleum reservoir fluids in porous media. It provides an accurate and unbiased prediction of the performance of petroleum reservoirs under different operating conditions. Despite its advantages, reservoir simulation is computationally expensive; with typical full-field simulation models running for several hours. This limitation is worsened when simulating reservoirs with several equations for each cell, such as multiphysics or compositional reservoir simulation. The goal of this research is to provide a fast and accurate spatiotemporal machine-learning model that incorporates discretized governing mass balance equations for training. To achieve this, we propose …

Clocking In And Speaking Out: Navigating Workday Rhythms For Voice Behaviors, Katelyn M. Reeves

LSU Master's Theses

Employee voice behaviors help organizations identify problems, increase productivity, and enhance satisfaction. Most literature focuses on daily-level variations while neglecting potential within-day variations that may have a stronger impact on voice engagement. To investigate within-day variations, this thesis applies chronotype synchrony to explain resource depletion throughout the day, which will determine voice engagement. An experience sampling study with the day reconstruction method of 250 employees revealed that having a morning chronotype leads to a more promotive and prohibitive voice in the morning, with a decline throughout the day due to resource depletion increasing throughout the day. Further, individuals with evening …

Co2 In Flowing Freshwaters: Macro Scale Database Compilation, Addressing Ph Bias In Co2 Estimates, And Quantifying Cross-Scale Interactions, Timothy R. Toavs

LSU Doctoral Dissertations

This dissertation focuses on carbon dioxide (CO₂) dynamics in flowing freshwaters, contributing to the growing body of knowledge about inland water carbon cycles. The research is structured into three main chapters, each progressing towards the objective of utilizing variability in flowing freshwaters to further understand carbon dynamics, anthropogenic land cover impacts, and potential impacts from a changing climate. Chapter one compiles a 30-year dataset of pCO₂ measurements from flowing freshwater systems across the contiguous United States. This dataset, referred to as CDFLOW, includes over 750,000 pCO₂ estimates from more than 35,000 locations. It serves …

Phase Transitions In The Co-Doped Heusler Alloy Ni2mn1−Xcoxga, Jing Han Chen, Tej Poudel Chhetri, Nathaniel Wrobel, Xiaojian Bai, David P. Young, Igor Dubenko, Saikat Talapatra, Naushad Ali, Shane Stadler

Faculty Publications

The phase transitions of a series of Co-doped Heusler alloys, Ni 2 Mn 1 − x Co x Ga ( 0 ⩽ x ⩽ 0.2 ), were investigated experimentally using the magnetization measurements, x-ray diffraction, and calorimetric measurements up to their respective melting points. With increasing Co concentration, the structural transition temperatures, Curie temperatures, and melting points, were observed to increase, while the order-disorder transition temperatures decreased. Temperature-dependent x-ray diffraction experiments revealed two different crystal structures in the low-temperature martensite phase for different Co concentrations. However, above their respective structural transitions, both low-temperature crystal structures transformed into the L2 1 …

Controls On Spatial Variation In Porewater Methane Concentrations Across United States Tidal Wetlands, Erika L. Koontz, Sarah M. Parker, Alice E. Stearns, Brian J. Roberts, Caitlin M. Young, Lisamarie Windham-Myers, Patricia Y. Oikawa, J. Patrick Megonigal, Genevieve L. Noyce, Edward J. Buskey, R. Kyle Derby, Robert P. Dunn, Matthew C. Ferner, Julie L. Krask, Christina M. Marconi, Kelley B. Savage, Julie Shahan, Amanda C. Spivak, Kari A. St. Laurent, Jacob M. Argueta, Steven J. Baird, Kathryn M. Beheshti, Laura C. Crane, Kimberly A. Cressman, Jeffrey A. Crooks, Sarah H. Fernald, Jason A. Garwood, Jason S. Goldstein, Thomas M. Grothues, Andrea Habeck, Scott B. Lerberg, Samantha B. Lucas, Pamela Marcum

Faculty Publications

Tidal wetlands can be a substantial sink of greenhouse gases, which can be offset by variable methane (CH4) emissions under certain environmental conditions and anthropogenic interventions. Land managers and policymakers need maps of tidal wetland CH4 properties to make restoration decisions and inventory greenhouse gases. However, there is a mismatch in spatial scale between point-based sampling of porewater CH4 concentration and its predictors, and the coarser resolution mapping products used to upscale these data. We sampled porewater CH4 concentrations, salinity, sulfate (SO4²⁻), ammonium (NH4⁺), and total Fe using a spatially stratified sampling at 27 tidal wetlands …

Analyzing Errors Across Nonword Repetition Tasks For Clinical Utility Among Children Who Speak African American English, Tatum Carver-Dews

LSU Master's Theses

Purpose

Within the context of African American English (AAE), this study aimed to examine the clinical utility of three different types of NWR tasks to differentiate children with Developmental Language Disorder (DLD) from those who are typically developing (TD), by percentage of phonemes correct (PPC) and by type of error (e.g., consonants or vowels; omissions or substitutions). Additionally, this study allowed for examination of the relationship between the children’s NWR performance and their density of dialect-specific forms.

Methods

The data came from 50 kindergarteners (25 females, 25 males) who had participated in a multi-year study of childhood DLD within the …

Nipping Crime In The Bud: The Spatial Relationship Between Crime And Meeting People’S Needs, Alicia Cerquone

LSU Master's Theses

The recent high-profile killings of people by the police brought attention to police violence, and prompted activists to call for an end to police violence. Drawing from an understanding of strain theory (Merton, 1938; Farnworth & Leiber, 1989; Agnew, 1992; Agnew, 2001; Agnew, 2008) and Tucker and Cadora’s (2003) ideas of justice reinvestment, this research was designed with the belief that police funding can be better used to help people meet their basic needs of housing, healthcare, and education. This research is concerned with the spatial relationship between crime and the quality of social infrastructure, or the programs in place …

Lignin Cationization For The Removal Of Phosphates And Nitrates From Effluents Of Wastewater Treatment Plants, Fannyuy V. Kewir

LSU Master's Theses

The removal of phosphates and nitrates from wastewater treatment plant (WWTP) effluents is important for preventing pollution of receiving waters. In this study, we chemically modified alkaline lignin (aLN) with quaternary ammonium groups to obtain biodegradable cationic lignin (cLN). We characterized the cLN and tested its efficacy for removing phosphates and nitrates in a lab setting and on field-collected WWTP samples. Adsorption isotherm and kinetic studies were performed in aqueous media, and the effects of several variables (contact time, pH, initial concentration, and adsorbent dose) were investigated. The Langmuir isotherm described phosphate and nitrate adsorption well, with R2 values of …

Structure Of A Model Lipid Membrane Oxidized By Human 15-Lipoxygenase-2, Jamil Nemri, Cosme Morales, Nathaniel C. Gilbert, Jaroslaw Majewski, Marcia E. Newcomer, Crystal M. Vander Zanden

Faculty Publications

Enzyme-mediated lipid oxidation is an important regulatory event in cell signaling, with oxidized lipids being potent signaling molecules that can illicit dramatic changes in cell behavior. For example, peroxidation of an arachidonoyl poly-unsaturated fatty acid by the human enzyme 15-lipoxygenase-2 (15-LOX-2) has been associated with formation of atherosclerotic plaques. Previous work on synthetically oxidized membranes has shown that oxidized lipid tails will change their conformation to facilitate interactions between the peroxide group and the lipid headgroups. However, this phenomenon has not been directly observed for a lipid membrane that has undergone enzyme-catalyzed oxidation. In this study, we report on the …

Charging, Aggregation, And Electrostatic Dispersion Of Radioactive And Nonradioactive Particles In The Atmosphere, Yong Ha Kim, Sotira Yiacoumi, Costas Tsouris

Faculty Publications

Electrostatic dispersion can significantly impact the microphysical behavior of charged particles and ions until reaching zero space charge. However, although radioactive particles can be strongly charged in air, the influence of electrostatic dispersion has been neglected in understanding their behavior. This study is aimed at investigating the time evolution of the charge and size distributions of radioactive and nonradioactive particles in air and developing simple approaches for applications. With processes involving charging, aggregation, and electrostatic dispersion, a comprehensive population balance model (PBM) has been developed to examine particle charge/size distribution dynamics. It is shown that compared to nonradioactive particles, the …

Biological Control Of Roseau Cane Scale With Parasitoid Wasps In Louisiana, Tanner C. Sparks

LSU Doctoral Dissertations

Roseau cane scale, Nipponaclerda biwakoensis (Hemiptera: Aclerdidae) is an invasive species of scale insect negatively impacting Phragmites australis (Cyperales: Poaceae) stands within the Mississippi River Delta. The scales were first detected in 2017 from reports of Phragmites die-back within the MRD by landowners. Initial range surveys located RCS infested Phragmites stands were primarily limited to southeastern Louisiana with a single population near Port Arthur, Texas. Follow-up field surveys conducted annually from 2021 to 2023 monitoring further range expansion by the scale show the current range extends nearly 600 km between High Island, Texas and Bayou la Batre, Alabama. Climate matching …

Screen Media, Obesity, And Nutrition, Amanda E. Staiano, Alyssa M. Button, Gary S. Goldfield, Thomas N. Robinson, Jorge Mota, Susan J. Woolford, Peter T. Katzmarzyk

Population and Public Health Science Faculty Publications

This chapter provides an update on and the synthesis of the most current evidence on screen use, nutritional intake, and obesity in youth. The strongest evidence of a mechanism linking screen media use to obesity is through repeated exposures to unhealthy food marketing and excess eating while viewing screens. Evidence of the neurocognitive effects on dietary consumption via the effects of executive function, satiety, and memory is emerging. Interventions to reduce children's screen time or to incorporate screen media into improving nutrition and obesity outcomes have had mixed results. The evidence base is also limited by imprecise measurements of screen …

Digital Screen Media Use, Movement Behaviors, And Child Health, Mark S. Tremblay, Nicholas Kuzik, Stuart J.H. Biddle, Valerie Carson, Mai J.M. Chinapaw, Dorothea Dumuid, Wendy Yajun Huang, Travis J. Saunders, Amanda E. Staiano, Russell R. Pate

Population and Public Health Science Faculty Publications

This chapter summarizes the associations between children's digital screen media use (DSMU) and their health, within the 24-h movement behavior framework (physical activities, sedentary behaviors, sleep), provides recommendations for healthy DSMU, and highlights future research directions. Key concepts include behavior displacement, combined associations, and DSMU context and content. Displacement examples include more DSMU decreasing time for healthier behaviors (e.g., physical activity or sleep) or replacing reading books and magazines with DSMU alternatives (e.g., texting, social media). How DSMU affects the relationships between various combinations of movement behaviors and children's health is largely unknown. Total DSMU is most frequently studied, but …

Nanofabrication Of Tetraphenyl Porphyrin Surface Assemblies Linked With Tin Tetrachloride: A Scanning Probe Microscopy Investigation, Quynh Do

LSU Doctoral Dissertations

Scanning probe microscopy (SPM) and colloidal lithography methods were used to study the covalent coupling of porphyrins to surfaces. In this dissertation, experimental methods for SPM operation, techniques, and applications are described. Measurement of tip-sample interactions between a sharp tip and surface is translated into digital image data maps with x-, y-, and z-data. Colloidal lithography can be used to fabricate test platforms for AFM studies. The periodicity and arrangement of the designed nanostructures is determined by the size of the colloidal particles used for surface masks. Data processing is required to obtain images and topography information from raw AFM …

Electrospinning Of Heterogeneous Nanofibers: A Review, Dinkar Regmi, Jin Woo Choi, Jian Xu

Faculty Publications

Electrospinning is a straightforward approach for efficiently creating continuous fibers within the submicron to nanometer size range. Electrospun fibers possess excellent properties like high porosity, large specific surface area, tunable morphology, small diameter, etc., making them desirable in various applications. Because of its various properties, polymer is one of the most used materials as the spinning solution in electrospinning. Electrospun polymeric fibers, by themselves, may serve limited applications. Therefore, they are usually mixed with other materials to serve many applications. There are many ways in which these other materials are mixed with polymers in electrospinning, like doping, surface treatment, functionalization, …

Addressing Agency In Intersectional Leadership: The Consequences Of Agentic Leader Behaviors For Black And White Men And Women In Leadership, Sydney Roux

LSU Master's Theses

As Black women gain representation in business and entrepreneurial leadership, it is important to consider how these women will be perceived as leaders. Role congruity theory (RCT) posits that women’s gender roles do not align with the leadership role which often negatively impacts leader evaluations. However, RCT is often employed without a racial context where women are presumed to be White, and thus, it is unclear if the same assumptions can be applied to Black women. Leadership scholars have identified the ways in which attributions and expectations of leaders are shaped by both demographic characteristics and behavioral events. Because Black …

Carbon Dioxide Fluxes And The Dominant Role Of Vegetation In Recently Created And Reference Gulf Coast Marshes, A. Muench, T. Elsey-Quirk, J. R. White, R. D. Delaune

Faculty Publications

Coastal wetlands are one of the most productive ecosystems on Earth with the capacity to sequester large amounts of carbon dioxide (CO2). Wetland loss due to anthropogenic and natural causes reduces the carbon (C) storage capacity and potentially releases previously fixed C in biomass and soil to the water column and atmosphere through decomposition. Coastal wetland restoration has the potential to mitigate some of the C losses depending on the balance of C fluxes. However, the role of vegetation and environmental conditions in governing rates of C accumulation in restoration sites is not well resolved. The purpose of this study …

Net Evaporation-Induced Mangrove Area Loss Across Low-Lying Caribbean Islands, Isamar M. Cortés, Jorge Lorenzo-Trueba, Andre S. Rovai, Robert R. Twilley, Mark Chopping, Temilola Fatoyinbo

Faculty Publications

Although mangroves provide many beneficial ecosystem services, such as blue carbon storage and coastal protection, they are currently under threat due to changes in climate conditions, such as prolonged drought exposure. Under drought conditions, evaporation exceeds precipitation and high soil salinities can lead to stunted growth and die-back. To quantify this interplay, we developed a database for low-lying and uninhabited mangrove islands in the Caribbean under various evaporation and precipitation regimes. We extracted physical and biological information from each island using remote sensing techniques and coupled it with a process-based model. We used this database to develop a model that …

Seasonal Variability In The Feeding Ecology Of An Oceanic Predator, Mitchell S. Lovell, Michael J. Polito, Josef A. Schuster, Emily E. Shallow, Alexis M. Janosik, Brett J. Falterman, Michael A. Dance

Faculty Publications

Complementary approaches (stomach contents, DNA barcoding, and stable isotopes) were used to examine seasonal shifts in the feeding ecology of an oceanic predator, yellowfin tuna (Thunnus albacares, n = 577), in the northern Gulf of Mexico. DNA barcoding greatly enhanced dietary resolution and seasonally distinct prey assemblages were observed for both sub-adults and adults. In general, diet was characterized by ommastrephid squids and exocoetids in spring, juvenile fishes (i.e., carangids and scombrids) in summer, migratory coastal fishes during fall, and an increased consumption of planktonic prey (e.g., amphipods) in winter. Seasonal variability in bulk stable isotope values (δ¹³C, …

A Temperature Tipping Point In Hypoxic Zone Size, R. Eugene Turner, Nancy N. Rabalais, Cassandra N. Glaspie

Faculty Publications

Temperature increases will have ubiquitous effects on aquatic food webs, from microbes to consumers, and affect the quality and quantity of carbon flows within and between water layers. A decline in the biological pump moving carbon from surface to lower layers is anticipated. We reviewed 37 years of data on hypoxic zone size and water quality in the northern Gulf of Mexico to determine if air and bottom water temperature increases (0.5°C decade⁻¹) are significantly related to variations in its areal size. There was no significant decline in important river water quality in the 24 years since the …

Detecting, Attributing, And Projecting Global Marine Ecosystem And Fisheries Change: Fishmip 2.0, Julia L. Blanchard, Camilla Novaglio, Olivier Maury, Cheryl S. Harrison, Colleen M. Petrik, Denisse Fierro-Arcos, Kelly Ortega-Cisneros, Andrea Bryndum-Buchholz, Tyler D. Eddy, Ryan Heneghan, Kelsey Roberts, Jacob Schewe, Daniele Bianchi, Jerome Guiet, P. Daniel Van Denderen, Juliano Palacios-Abrantes, Xiao Liu, Charles A. Stock, Yannick Rousseau, Matthias Büchner, Ezekiel O. Adekoya, Cathy Bulman, William Cheung, Villy Christensen, Marta Coll, Leonardo Capitani, Samik Datta, Elizabeth A. Fulton, Alba Fuster, Victoria Garza, Matthieu Lengaigne, Max Lindmark, Kieran Murphy

Faculty Publications

There is an urgent need for models that can robustly detect past and project future ecosystem changes and risks to the services that they provide to people. The Fisheries and Marine Ecosystem Model Intercomparison Project (FishMIP) was established to develop model ensembles for projecting long-term impacts of climate change on fisheries and marine ecosystems while informing policy at spatio-temporal scales relevant to the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP) framework. While contributing FishMIP models have improved over time, large uncertainties in projections remain, particularly in coastal and shelf seas where most of the world's fisheries occur. Furthermore, previous FishMIP climate …

Qacdes: Qos-Aware Context-Sensitive Design Of Cyber-Physical Systems, Subhajit Sidhanta, Chanachok Chokwitthaya, Yimin Zhu, Supratik Mukhopadhyay

Faculty Publications

There is a lot of confusion and ambiguity regarding the quantification of the Quality of Service (QoS) of a system, especially for cyber-physical systems (CPS) involved in automating or controlling the operations in built environments and critical urban infrastructures, such as office buildings, factories, transportation systems, smart cities, etc. In these cases, the QoS, as experienced by human users, depends on the context in which they (i.e., humans) interact with these systems. Traditionally, the QoS of a CPS has been defined in terms of absolute metrics. Such measures are unable to take into account the variations in performance due to …

Review Of Bad Nature, Michael F. Russo

Faculty Publications

No abstract provided.

Glucagon-Like Peptide-1 Receptor Agonist-Based Agents And Weight Loss Composition: Filling The Gaps, Robert L. Dubin, Steven B. Heymsfield, Eric Ravussin, Frank L. Greenway

Clinical Research Faculty Publications

Excess adiposity is at the root of type 2 diabetes (T2D). Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as first-line treatments for T2D based on significant weight loss results. The composition of weight loss using most diets consists of < 25% fat-free mass (FFM) loss, with the remainder from fat stores. Higher amounts of weight loss (achieved with metabolic bariatric surgery) result in greater reductions in FFM. Our aim was to assess the impact that GLP-1RA-based treatments have on FFM. We analysed studies that reported changes in FFM with the following agents: exenatide, liraglutide, semaglutide, and the dual incretin receptor agonist tirzepatide. We performed an analysis of various weight loss interventions to provide a reference for expected changes in FFM. We evaluated studies using dual-energy X-ray absorptiometry (DXA) for measuring FFM (a crude surrogate for skeletal muscle). In evaluating the composition of weight loss, the percentage lost as fat-free mass (%FFML) was equal to ΔFFM/total weight change. The %FFML using GLP-1RA-based agents was between 20% and 40%. In the 28 clinical trials evaluated, the proportion of FFM loss was highly variable, but the majority reported %FFML exceeding 25%. Our review was limited to small substudies and the use of DXA, which does not measure skeletal muscle mass directly. Since FFM contains a variable amount of muscle (approximately 55%), this indirect measure may explain the heterogeneity in the data. Assessing quantity and quality of skeletal muscle using advanced imaging (magnetic resonance imaging) with functional testing will help fill the gaps in our current understanding.

The Role Of Government Assistance, Housing, And Employment On Postpartum Maternal Health Across Income And Race: A Mixed Methods Study, Chelsea L. Kracht, Kelsey O. Goynes, Madison Dickey, Briasha Jones, Emerson Simeon, Jada Butler, Maryam Kebbe, Kaja Falkenhain, Emily W. Harville, Elizabeth F. Sutton, Leanne M. Redman

Clinical Research Faculty Publications

Background: Stressful large-scale events, such as the COVID-19 pandemic and natural disasters, impact birthing individuals’ postpartum experiences and their mental health. Resultant changes in government assistance, housing, and employment may further exacerbate these impacts, with differences experienced by varying income levels and races. This study aimed to examine maternal depression and anxiety in postpartum individuals by income and race during a stressful large-scale event, and the mediating role of government assistance, housing, and employment. Methods: An explanatory sequential mixed methods study was conducted (QUANT + QUAL). For aim 1 (quantitative), birthing individuals who delivered during peak pandemic (June 2020 - …

Precision Prognostics For Cardiovascular Disease In Type 2 Diabetes: A Systematic Review And Meta-Analysis, Abrar Ahmad, Lee Ling Lim, Mario Luca Morieri, Claudia Ha Ting Tam, Feifei Cheng, Tinashe Chikowore, Monika Dudenhöffer-Pfeifer, Hugo Fitipaldi, Chuiguo Huang, Sarah Kanbour, Sudipa Sarkar, Robert Wilhelm Koivula, Ayesha A. Motala, Sok Cin Tye, Gechang Yu, Yingchai Zhang, Michele Provenzano, Diana Sherifali, Russell J. De Souza, Russell J. De Souza, Deirdre Kay Tobias, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo

Clinical Research Faculty Publications

Background: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with Type 2 diabetes (T2D). Methods: We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that may improve CVD risk prediction in T2D. Out of 9380 studies identified, 416 studies met inclusion criteria. Outcomes were reported for 321 biomarker studies, 48 genetic marker studies, and 47 risk score/model studies. Results: Out of all evaluated biomarkers, only 13 showed improvement in prediction performance. Results of pooled meta-analyses, non-pooled analyses, and assessments of improvement in prediction performance and risk of …

A Systematic Umbrella Review And Meta-Meta-Analysis Of Ehealth And Mhealth Interventions For Improving Lifestyle Behaviours, Ben Singh, Mavra Ahmed, Amanda E. Staiano, Claire Gough, Jasmine Petersen, Corneel Vandelanotte, Chelsea Kracht, Christopher Huong, Zenong Yin, Maria F. Vasiloglou, Chen Chia Pan, Camille E. Short, Matthew Mclaughlin, Lauren Von Klinggraeff, Christopher D. Pfledderer, Lisa J. Moran, Alyssa M. Button, Carol A. Maher

Population and Public Health Science Faculty Publications

The aim of this meta-meta-analysis was to systematically review randomised controlled trial (RCT) evidence examining the effectiveness of e- and m-Health interventions designed to improve physical activity, sedentary behaviour, healthy eating and sleep. Nine electronic databases were searched for eligible studies published from inception to 1 June 2023. Systematic reviews with meta-analyses of RCTs that evaluate e- and m-Health interventions designed to improve physical activity, sedentary behaviour, sleep and healthy eating in any adult population were included. Forty-seven meta-analyses were included, comprising of 507 RCTs and 206,873 participants. Interventions involved mobile apps, web-based and SMS interventions, with 14 focused on …

Multiomics Analysis To Explore Blood Metabolite Biomarkers In An Alzheimer’S Disease Neuroimaging Initiative Cohort, Takaki Oka, Yuki Matsuzawa, Momoka Tsuneyoshi, Yoshitaka Nakamura, Ken Aoshima, Hiroshi Tsugawa, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Clinical Research Faculty Publications

Alzheimer's disease (AD) is a neurodegenerative disease that commonly causes dementia. Identifying biomarkers for the early detection of AD is an emerging need, as brain dysfunction begins two decades before the onset of clinical symptoms. To this end, we reanalyzed untargeted metabolomic mass spectrometry data from 905 patients enrolled in the AD Neuroimaging Initiative (ADNI) cohort using MS-DIAL, with 1,304,633 spectra of 39,108 unique biomolecules. Metabolic profiles of 93 hydrophilic metabolites were determined. Additionally, we integrated targeted lipidomic data (4873 samples from 1524 patients) to explore candidate biomarkers for predicting progressive mild cognitive impairment (pMCI) in patients diagnosed with AD …