Digital Commons Network^™

The Regulation Of Autoimmunity Genes In Pancreatic Β-Cells By Nf-Κb, Thomas Malone Martin

LSU Doctoral Dissertations

Type 1 diabetes (T1D) is an autoimmune disease where the immune system targets the pancreatic islet beta-cells, which are responsible for insulin production and secretion, leading to a state of insulin insufficiency. Many of the molecular details of disease onset and progression remain poorly understood, including key aspects of cytokine signaling. Therefore, we have examined some of the consequences of inflammatory cytokine signaling as a critical module relevant to T1D. Using interleukin-1 (IL-1) signaling as a well-defined paradigm for inflammation, we investigated key components of this signaling pathway in pancreatic beta-cells. We identified ICAM-1, one of the proteins expressed in …

Emily Somebody: A Chamber Opera In Three Acts, Rodrigo Afonso Salles Camargo

LSU Master's Theses

Emily Somebody is a chamber opera in three acts that tells the story of the friendship between the American poet Emily Dickinson and the man that would become her first editor, Mr. Thomas Higginson. This story, for me, is ultimately about a poet (or an artist) in the process of finding not only her own voice but also discovering what poetry and art mean to her, in the most genuine way, and standing up for these beliefs and values. All the lyrics used in this work are from Emily Dickinson’s poems and letters exchanged between her and Mr. Thomas Higginson.

Evaluating Form And Function Of Groundcovers And Their Environmental Impacts In Louisiana Landscapes, Thomas Maxwell Mckeown

LSU Master's Theses

Increasing environmental concerns are encouraging the adoption of sustainable landscapes that have environmental, social, and financial benefits. Ornamental groundcover systems are touted as sustainable landscape features due to the associated decreased demand of water, fertilizer, pesticide, and maintenance; however, limited research exists on soil property effects, planting density, weed density, or consumer preferences of groundcovers. This study was aimed to gain a more thorough understanding of ornamental groundcovers systems and their environmental impacts. The effects of groundcover growth habit (matting; bunching) and irrigation delivery (micro spray; overhead) on soil temperature, volumetric water content (VWC), and electric conductivity (EC) along with …

The What And When Of Psychomotor Retardation: A Multimodal Approach, Ole Edvard Granrud

LSU Master's Theses

Psychomotor retardation (PMR) is a diagnostic criterion that reflects a gross slowing of movement, speech, and thought. More so, PMR is a transdiagnostic, pervasive source of impairment and distress that can be observed across disorders, such as Major Depressive Disorder (MDD), Schizophrenia (SZ), and Bipolar Disorder (BD). In clinical settings, PMR is associated with more severe psychopathology and is used to both inform treatment and predict long-term treatment outcomes. However, despite being clinically meaningful, PMR is poorly understood and is often conceptualized as a motor disturbance that happens in isolation from, rather than concurrently with, higher-order cognitive-emotional processes – such …

Quantifying Mud Settling Velocity As A Function Of Turbulence And Salinity In A Deltaic Estuary, Michael W. Mcdonell

LSU Master's Theses

Mud settling velocity is controlled by flocculation, which in turn strongly depends on turbulence and on the chemistry and biology of the water-sediment mixture. As a result, mud settling velocity can be poorly constrained in coastal areas and vary in space and time by orders of magnitude. Here we quantified mud settling velocity in Barataria Basin, a deltaic estuary in Louisiana (USA), using three independent methods: eddy covariance (one station for 200 days), floc cameras (4 stations at one time), and Rouse profile inversion (14 stations, replicated 10-30 times each). Eddy covariance indicates that settling velocity increases with turbulence, at …

Deposition, Material Characterization, And Mechanical Testing Of Cr Containing Diamond-Like Carbon Films, Nicholas Anderson

LSU Master's Theses

A series of amorphous hydrogenated chromium containing diamond-like carbon films were deposited on 316 stainless steel substrates with a chromium interlayer through inductively coupled plasma assisted direct current magnetron sputtering. Details on the deposition process of these films are discussed. The film is characterized using scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, energy dispersive spectroscopy, and transmission electron microscopy. The coating hardness and indentation modulus is measured by instrumented nanoindentation. The coefficient of friction and the upper bound of the coating wear coefficient is measured using the pin-on-disk method. The fracture toughness of the diamond-like carbon film and a …

Exploring The Interactive, Linguistic, And Conceptual Dimensions Of Parent Input And Their Role In Children's Pragmatic Development, Nickolas T. Day

LSU Master's Theses

The development of children’s pragmatic language, which can be defined as conversational competence in social contexts, has been attributed to variation in the language they hear in their environment. When studying the impact language input has on pragmatic development, it is important for clinicians and linguists to measure both the quantity and quality of this language input. Measures of quality, however, are much more relevant when studying the development of pragmatic language, as discussed in Zhang (2020) and Hirsh-Pasek et al. (2015). Rowe and Snow (2016) discussed three dimensions of language quality: interactive, linguistic and conceptual. There is a current …

A New Test Of The News: An Examination Of The New York Times And Cnn Coverage Of The War In Ukraine, Hannah Ross

LSU Master's Theses

Russia launched a military invasion of Ukraine on 24 February 2022, setting off Europe’s largest war since World War II. The war captured the attention of American news organizations, which gave the conflict unprecedented levels of coverage. This thesis tested the coverage of the war in Ukraine by two major American news outlets: The New York Times and CNN. This study used qualitative content analysis to examine the top four front-page stories of the Times and CNN Newsroom show. Two timeframes were used to analyze these materials: February 24, 2022, to March 9, 2022, and September 17, 2022, to September …

Identifying Key Language Research Priorities In Autistic Children According To Parents, Taylor Hale

LSU Master's Theses

The lack of involvement of the autistic community and its stakeholders in autism research has led to a call to action. At present, autism researchers have limited knowledge about stakeholders’ priorities for research. The current study aimed to bridge the disconnect between the extant autism research and the recent neurodiversity movement by surveying key stakeholders – parents of autistic children – on their perspectives on autism research that focuses on language. Twenty-six parents of autistic children completed an online survey on their views on autism language research with an option to participate in a follow-up interview. Six parents participated in …

Snow Distribution And Influence In Taylor Valley, Antarctica, Using Remote Sensing, Katherine Mcnulty, Peter Doran, Mark Salvatore, Suniti Karunatillake

LSU Master's Theses

The McMurdo Dry Valleys is the largest ice-free area in Antarctica, but seasonal snow covers the valley floors sporadically throughout the year. In this study, a model to estimate areal snow coverage from satellite imagery was created. An area-volume model was created to estimate the amount of snow water equivalent (SWE) from the snow area extracted from the imagery. Snow cover influences the total albedo, the hydrologic budget, and the soil moisture and soil temperature in Taylor Valley (TV). Quantifying snow precipitation in TV is challenging because snow redistributes with winds, sublimates, or melts within a short period. Previous estimates …

Effect Of Furosemide Administration On Plasma Analytes And Urine Enzyme Excretion In Two Reptilian Species, Kathryn Metcalf

LSU Master's Theses

Renal disease is a common ailment of captive reptiles that is often closely linked to chronic, subclinical states of dehydration. Currently, the diagnosis of renal disease in reptiles is poorly characterized and often relies on invasive diagnostic techniques (e.g., renal biopsy) for definitive diagnosis. A potential outlet for the further characterization of renal dysfunction in reptiles is the induction of dehydration by furosemide therapy. Furosemide is a loop diuretic that is commonly used in mammalian patients for the treatment of congestive heart failure. The utility of furosemide in reptiles is poorly characterized, however, both experimental and clinical utility of this …

The Possibility Of Relationships With Others, Joshua Severud

LSU Master's Theses

Levinas offers a rich philosophical insight into the kind of responsibility and ethics that we must have for the Other. This involves a certain conception of what it means to be hospitable which turns out to be impossible. In order to talk about how this impossible relationship can occur, I use Heidegger’s description of the existential Being-with structure and Derrida’s conception of the event in order to make sense of how this Levinasian relationship can possibly exist in spite of—or thanks to—its impossibility.

Exploring The Effects Of Individuals’ Perceived Prototypicality Within A Fandom, Keely Diebold

LSU Master's Theses

Passionate fandoms centered on popular film and television series can elicit large-scale positive fan activity. At the same time, however, negative consequences can arise as factions or subsets of members with varying opinions arise within fandoms. One possible explanation for this phenomenon is varied levels among fandom members of how prototypical they view themselves within the context of that fandom. Research on social groups, however, has historically looked exclusively at perceptions of others' prototypicality and not of the self. Drawing on theories of social identity (SIT) and self-categorization (SCT), this project serves to bridge this research gap by exploring to …

Examining Framing Of Local And National Media Coverage Of Sandy Hook And Robb Elementary School Shootings, Gabrielle L. Debruler

LSU Master's Theses

There have been over 350 K-12 school shootings since the shootings at Columbine High School in 1999 (Cox et al., 2023). Thousands of journalists cover these attacks each in their own way with unique motives. This information goes to the public, and it is up to that person how they want to consume the story and view the shooting. National and local journalists tend to cover school shootings quite differently throughout time with unique frames. The shootings at Sandy Hook Elementary and Robb Elementary Schools illustrate this framing distinctively.

Through a qualitative study of national and local coverage of the …

Gulf Sturgeon Mesohabitat Use And Movement In The Lower Pearl River Louisiana-Mississippi, Amanda Popovich

LSU Master's Theses

After spring migrations to natal rivers Gulf Sturgeon Acipenser oxyrinchus desotoi reside in freshwater holding areas prior to fall emigrations to nearby estuaries. Limited published information on the physical habitat characteristics of these holding areas is available, especially for juvenile fish in the western portion of the Gulf Sturgeon’s distribution. To further investigate freshwater occupancy and movement patterns, 32 acoustic receivers were deployed from late April to October of 2021 and 2022 in 1600-m reaches distributed throughout the lower Pearl River, Louisiana-Mississippi, the westernmost river within their distribution. Generalized linear mixed models and multi-state models were used to determine what …

Matroid Generalizations Of Some Graph Results, Cameron Crenshaw

LSU Doctoral Dissertations

The edges of a graph have natural cyclic orderings. We investigate the matroids for which a similar cyclic ordering of the circuits is possible. A full characterization of the non-binary matroids with this property is given. Evidence of the difficulty of this problem for binary matroids is presented, along with a partial result for binary orderable matroids.

For a graph G, the ratio of |E(G)| to the minimum degree of G has a natural lower bound. For a matroid M that is representable over a finite field, we generalize this to a lower bound on …

Mapping, Modeling, And Predicting Extreme Flood Events With Cloud Computing, Dan Tian

LSU Doctoral Dissertations

Floods represent one of the most severe natural disasters worldwide. It is crucial to accurately assess flood hazards to mitigate the impact and enhance community resilience. This study focuses on three key components of flood hazard management, including (1) flood frequency estimation, (2) inundation delineation, and (3) flood susceptibility assessment. The first project presents a Bayesian Log-Pearson Type III model with Spatial Priors (BLP3-SP) that utilizes spatial regression priors to enhance the accuracy of flood frequency estimation for sites with limited data. The method is compared with two other algorithms with different priors. The results indicate that BLP3-SP performs the …

Finite Element Methods For Elliptic Optimal Control Problems With General Tracking, Seonghee Jeong

LSU Doctoral Dissertations

This dissertation concerns a linear-quadratic elliptic distributed optimal control problem with pointwise state constraints in two spatial dimensions, where the cost function tracks the state at points, curves and regions of a domain.

First we explore the elliptic optimal control problem subject to pointwise control constraints. This problem is reduced into a problem that only involves the control. The solution of the reduced problem is characterized by a variational inequality. Then we introduce the elliptic optimal control problem with general tracking and pointwise state constraints. Here we reformulate the optimal control problem into a problem that only involves the state, …

First-Order Algorithms For Nonlinear Structured Optimization, Miao Zhang

LSU Doctoral Dissertations

Nonlinear optimization is a critical branch in applied mathematics and has attracted wide attention due to its popularity in practical applications. In this work, we present two methods which use first-order information to solve two typical classes of nonlinear structured optimization problems.

For a class of unconstrained nonconvex composite optimization problems where the objective is the sum of a smooth but possibly nonconvex function and a convex but possibly nonsmooth function, we propose a unified proximal gradient method with extrapolation, which provides unified treatment to convex and nonconvex problems. The method achieves the best-known convergence rate for first-order methods when …

Blockchain Accelerators And An Application On Covid-19 Contact Tracing, Tao Lu

LSU Doctoral Dissertations

Blockchain technology has been an emerging technology in recent years. Its nature of decentralization and anonymity enables many applications to be built in a trustless environment but can still be validated and agreed upon by all the participants. Ever since the invention of blockchain technology, its concepts and forms are explored extensively, and it has shown the potential to be used in many industries. However, the low efficiency and the poor performance have prevented the technology to be adopted in practical largescale usage. In this dissertation, we present three major works around blockchain technology. The first one is BPU, an …

A Study Of Max Reger's Four Sonatas For Solo Violin, Op. 42, No. 1: Analyzing Musical Structure And Exploring Performance Approaches, Hayoung Cho

LSU Doctoral Dissertations

This dissertation examines four sonatas for solo violin op.42, no.1 by Max Reger, a composer relatively unknown in the modern era despite his significant contributions to the violin repertoire. Reger's lack of popularity as a composer for the violin and the infrequency of his solo violin sonatas' performance and recording are the main reasons for this study. The research is based on a comprehensive analysis of Reger's musical language and violin works focusing on his use of polyphonic textures, rhythmic and melodic phrasing, and ornamentation. By examining Reger's compositional techniques, this study aims to shed light on his unique approach …

Attentional Focus Effects On Motor Variability, Charlend Kenneth Howard

LSU Doctoral Dissertations

Subtle changes in task instructions with associated changes of one’s focus of attention (FOA) can have measurable effects on performance and learning of complex motor skills (Wulf, 2013). The beneficial effects of adopting an external focus of attention (EF) have been well-documented in physical environments, and recently have also been demonstrated in virtual reality (VR) environments (Cochran, Aiken, Rhea, & Raisbeck, 2021; Yamada, Kuznetsov, Diekfuss, & Raisbeck, 2021). However, these studies primarily focused on performance outcomes (such as error and accuracy), with relatively less emphasis on movement coordination. Given that most human movements are motor abundant (more degrees of freedom …

Geophysical Characterization Of Underground Storage In Salt Domes During The Clean Energy Transition, Joses B. Omojola

LSU Master's Theses

Safely transforming geological formations into cost-effective underground storage is critical for the US energy security and global energy transition. Seasonal energy demand requires relatively cheap, impermeable, non-reactive materials for storing vast amounts of natural gas and hydrogen. Due to their low risk of fracturing and leakage, salt formations are ideal for these purposes however, pressure variations during drawdown, differential salt creep, and reactivation of pre-existing fractures along boundary shear zone(s) (BSZ) can be detrimental to salt cavern safety and long-term cavern operations. Several environmental disasters at storage facilities in the US and Europe, have created a need to understand how …

News(?)Papers: A Typology Of Fake News, 1880-1920, Olivia G. Romaguera

LSU Master's Theses

“Fake news” is a malleable concept. It can be beaten and reshaped to fit many different contexts. One widely accepted definition of fake news is false information purporting itself to be factual. Another is information that is factual but called “fake” in order to discredit it. Concern over the spread of fake news increased in recent years. But preoccupation with what is happening today has left a gap in our understanding of the phenomenon, specifically its roots in the past. “Fake news” was present when news technology was relatively primitive; it is not essentially a function of such modern advancements …

Natural Lights & Natural Rights: The Problem Of The New Classical Natural Law Theory, Charles Neville Cacciatore

LSU Master's Theses

The present work examines the natural law jurisprudence of John Finnis. It argues that Finnis’s teaching is a genuinely new natural law theory. Finnis’s jurisprudence is not a re- presentation of the jurisprudence of St. Thomas Aquinas because its central element—a doctrine of natural rights—is a departure from Aquinas’s natural law teaching. In support of these claims, the present work relies upon the scholarship of Ernest L. Fortin, A.A. Following Fr. Fortin, it presents an understanding of the natural law that endorses a clear distinction between natural right and natural rights—between premodern political philosophy and modern political philosophy.

The Nature And Role Of Phenomenology In Hegel And Heidegger, Gabriel W. Connor

LSU Master's Theses

In this work I compare Hegel and Heidegger’s conception of phenomenology and its role in their thinking. Though these two thinkers are not often examined from this angle, and though there is controversy surrounding just how phenomenological each thinker might actually be, an examination of the two thinkers in this regard serves to identify interesting connections between Hegel and Heidegger while also raising questions about phenomenology in general. In short, I seek to establish that phenomenology in both Hegel and Heidegger is not adequately understood unless it is placed in the context of each thinker’s conception of human freedom along …

Machine-Learning Approaches For Developing An Autograder For High School-Level Cs-For-All Initiatives, Sirazum Munira Tisha

LSU Doctoral Dissertations

Most existing autograders used for grading programming assignments are based on unit testing, which is tedious to implement for programs with graphical output and does not allow testing for other code aspects, such as programming style or structure. We present a novel autograding approach based on machine learning that can successfully check the quality of coding assignments from a high school-level CS-for-all computational thinking course. For evaluating our autograder, we graded 2,675 samples from five different assignments from the past three years, including open-ended problems from different units of the course curriculum. Our autograder uses features based on lexical analysis …

Switch-Like Behavior Of Lysosomes And Vcp Supports Spermatocyte Health And Development In Drosophila, Tyler James Butsch

LSU Doctoral Dissertations

Changes to societal norms, such as the educational, marital, and child-bearing expectations have coincided with significant increases in infertility worldwide. Surprisingly, male infertility is responsible for approximately half of all infertility cases worldwide. Thus, a better understanding of sperm development, and how it is affected by age, may permit the design and application of therapeutics to treat various cases male infertility. Here, I have found that lysosomes acidify as germ cells enter the spermatocyte stage. Once active, lysosomes turn over E-cadherin, and likely other proteins, to support plasma membrane stability. Notably, aging negatively impacts lysosome acidification, which can be reversed …

Sl(2,Z) Representations And 2-Semiregular Modular Categories, Samuel Nathan Wilson

LSU Doctoral Dissertations

We address the open question of which representations of the modular group SL(2,Z) can be realized by a modular category. In order to investigate this problem, we introduce the concept of a symmetrizable representation of SL(2,Z) and show that this property is necessary for the representation to be realized. We then prove that all congruence representations of SL(2,Z) are symmetrizable. The proof involves constructing a symmetric basis, which greatly aids in further calculation. We apply this result to the reconstruction of modular category data from representations, as well as to the classification of semiregular categories, which are defined via an …

Svip Dependent Tubular Lysosomal Restoration: A New Direction In Vcp Diseases, Ankita Basu

LSU Doctoral Dissertations

Multisystem Proteinopathy-1 (MSP-1) is a rare, autosomal dominant, degenerative disease resulting from single amino acid mis-sense mutations in the AAA+ ATPase, Valosin containing protein (VCP). Patients with VCP mutations vary widely in their pathology and clinical penetrance, making it difficult to devise effective treatment strategies. To investigate the pathology of VCP- related disease, we engineered CRISPR knock-in Drosophila models for nine MSP-1 associated VCP mutations. These mutant animals mimic human MSP-1 disease phenotypes, including progressive mobility decline and accumulation of protein aggregates, making them excellent models to study the pathology of VCP associated mutations and test potential treatment strategies. At …