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Effect Of Electronegativity On Environmentally Persistent Free Radical (Epfr) Formation, Persistence, And Toxicity On Transition Metal Oxides, Syed Monjur Ahmed Oct 2024

Effect Of Electronegativity On Environmentally Persistent Free Radical (Epfr) Formation, Persistence, And Toxicity On Transition Metal Oxides, Syed Monjur Ahmed

LSU Doctoral Dissertations

Environmentally persistent free radicals (EPFRs) are a group of emerging environmental pollutants. Owing to their resonance structures, EPFRs have significantly higher lifetimes than typical free radicals, and can induce the formation of reactive oxygen species (ROS) known to cause pulmonary and cardiovascular dysfunction. EPFRs form by the adsorption of organic precursors on a transition metal oxide (TMO) surface and exhibit enough stability to cause negative health and environmental effects. While aromatic and substituted aromatic precursors form EPFRs on TMO surface at elevated temperatures and numerous substituted organics are ubiquitous in various industrial processes and household products, studies have largely overlooked …

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Rootzone Soil Moisture Dynamics Using Terrestrial Water-Energy Coupling, Vinit Sehgal, Binayak P. Mohanty, Rolf H. Reichle Oct 2024

Rootzone Soil Moisture Dynamics Using Terrestrial Water-Energy Coupling, Vinit Sehgal, Binayak P. Mohanty, Rolf H. Reichle

Faculty Publications

A lack of high-density rootzone soil moisture (θRZ) observations limits the estimation of continental-scale, space-time contiguous θRZ dynamics. We derive a proxy of daily θRZ dynamics — active rootzone degree of saturation (SRZ) — by recursive low-pass (LP) filtering of surface soil moisture (θS) within a terrestrial water-energy coupling (WEC) framework. We estimate the LP filter parameters and WEC thresholds for the piecewise-linear coupling between SRZ and evaporative fraction (EF) at remote sensing and field scale over the Contiguous U.S. We use θS from the Soil Moisture Active-Passive (SMAP) satellite and 218 in-situ stations, with EF from the Moderate Resolution …

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Development And Evaluation Of A Colorimetric Lamp Based-Assay Targeting The Bacteroides Hf183 Marker For Tracking Sewage Pollution In Environmental Waters, Mariah C.A. Do Nascimento, Wendy J.M. Smith, Metasebia Gebrewold, Yawen Liu, Stuart L. Simpson, Aaron Bivins, Paula Rahal, Warish Ahmed Oct 2024

Development And Evaluation Of A Colorimetric Lamp Based-Assay Targeting The Bacteroides Hf183 Marker For Tracking Sewage Pollution In Environmental Waters, Mariah C.A. Do Nascimento, Wendy J.M. Smith, Metasebia Gebrewold, Yawen Liu, Stuart L. Simpson, Aaron Bivins, Paula Rahal, Warish Ahmed

Faculty Publications

Surface waters are vulnerable to contamination by human and animal feces, posing risks to human health due to potential exposure to enteric pathogens. This research developed a colorimetric loop-mediated isothermal amplification (cLAMP) assay to detect sewage associated Bacteroides dorei HF183/BacR287 (HF183) marker in wastewater and environmental water samples. The host sensitivity and host specificity of the assay were evaluated, and their performance was compared to the Bacteroides HF183 qPCR assay using control materials (gBlocks), environmental water samples seeded with untreated sewage, and ambient environmental water samples. In serial dilutions of control materials, qPCR produced quantifiable data across all dilutions, while …

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Identification Of An Ionic Mechanism For Erα-Mediated Rapid Excitation In Neurons, Meng Yu, Na Yin, Bing Feng, Peiyu Gao, Kaifan Yu, Hesong Liu, Hailan Liu, Yongxiang Li, Olivia Z. Ginnard, Kristine M. Conde, Mengjie Wang, Xing Fang, Longlong Tu, Jonathan C. Bean, Qingzhuo Liu, Yue Deng, Yuxue Yang, Junying Han, Sanika V. Jossy, Megan L. Burt, Huey Zhong Wong, Yongjie Yang, Benjamin R. Arenkiel, Yang He, Shaodong Guo, Pierre Gourdy, Jean Francois Arnal, Francoise Lenfant, Zhao Wang, Chunmei Wang, Yanlin He, Yong Xu Oct 2024

Identification Of An Ionic Mechanism For Erα-Mediated Rapid Excitation In Neurons, Meng Yu, Na Yin, Bing Feng, Peiyu Gao, Kaifan Yu, Hesong Liu, Hailan Liu, Yongxiang Li, Olivia Z. Ginnard, Kristine M. Conde, Mengjie Wang, Xing Fang, Longlong Tu, Jonathan C. Bean, Qingzhuo Liu, Yue Deng, Yuxue Yang, Junying Han, Sanika V. Jossy, Megan L. Burt, Huey Zhong Wong, Yongjie Yang, Benjamin R. Arenkiel, Yang He, Shaodong Guo, Pierre Gourdy, Jean Francois Arnal, Francoise Lenfant, Zhao Wang, Chunmei Wang, Yanlin He, Yong Xu

Division of Basic Science Faculty Publications

The major female ovarian hormone, 17β-estradiol (E2), can alter neuronal excitability within milliseconds to regulate a variety of physiological processes. Estrogen receptor-α (ERα), classically known as a nuclear receptor, exists as a membrane-bound receptor to mediate this rapid action of E2, but the ionic mechanisms remain unclear. Here, we show that a membrane channel protein, chloride intracellular channel protein-1 (Clic1), can physically interact with ERα with a preference to the membrane-bound ERα. Clic1-mediated currents can be enhanced by E2 and reduced by its depletion. In addition, Clic1 currents are required to mediate the E2-induced rapid excitations in multiple brain ERα …

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The Genomes Of All Lungfish Inform On Genome Expansion And Tetrapod Evolution, Manfred Schartl, Joost M. Woltering, Iker Irisarri, Kang Du, Susanne Kneitz, Martin Pippel, Thomas Brown, Paolo Franchini, Jing Li, Ming Li, Mateus Adolfi, Sylke Winkler, Josane De Freitas Sousa, Zhuoxin Chen, Sandra Jacinto, Evgeny Z. Kvon, Luis Rogério Correa De Oliveira, Erika Monteiro, Danielson Baia Amaral, Thorsten Burmester, Domitille Chalopin, Alexander Suh, Eugene Myers, Oleg Simakov, Igor Schneider, Axel Meyer Oct 2024

The Genomes Of All Lungfish Inform On Genome Expansion And Tetrapod Evolution, Manfred Schartl, Joost M. Woltering, Iker Irisarri, Kang Du, Susanne Kneitz, Martin Pippel, Thomas Brown, Paolo Franchini, Jing Li, Ming Li, Mateus Adolfi, Sylke Winkler, Josane De Freitas Sousa, Zhuoxin Chen, Sandra Jacinto, Evgeny Z. Kvon, Luis Rogério Correa De Oliveira, Erika Monteiro, Danielson Baia Amaral, Thorsten Burmester, Domitille Chalopin, Alexander Suh, Eugene Myers, Oleg Simakov, Igor Schneider, Axel Meyer

Faculty Publications

The genomes of living lungfishes can inform on the molecular-developmental basis of the Devonian sarcopterygian fish–tetrapod transition. We de novo sequenced the genomes of the African (Protopterus annectens) and South American lungfishes (Lepidosiren paradoxa). The Lepidosiren genome (about 91 Gb, roughly 30 times the human genome) is the largest animal genome sequenced so far and more than twice the size of the Australian (Neoceratodus forsteri)1 and African2 lungfishes owing to enlarged intergenic regions and introns with high repeat content (about 90%). All lungfish genomes continue to expand as some transposable elements (TEs) are still active today. In particular, …

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The Role Of Benthic Fluxes In Acidifying The Bottom Waters In The Northern Gulf Of Mexico Hypoxic Zone Based On An Updated Water Column Biogeochemical-Seabed Diagenetic And Sediment Transport Model, Dongxiao Yin, Linlin Cui, Courtney K. Harris, Julia M. Moriarty, Hannah Beck, Kanchan Maiti Oct 2024

The Role Of Benthic Fluxes In Acidifying The Bottom Waters In The Northern Gulf Of Mexico Hypoxic Zone Based On An Updated Water Column Biogeochemical-Seabed Diagenetic And Sediment Transport Model, Dongxiao Yin, Linlin Cui, Courtney K. Harris, Julia M. Moriarty, Hannah Beck, Kanchan Maiti

Faculty Publications

The seabed and the water column are tightly coupled in shallow coastal environments. Numerical models of seabed-water interaction provide an alternative to observational studies that require concurrent measurements in both compartments, which are hard to obtain and rarely available. Here, we present a coupled model that includes water column biogeochemistry, seabed diagenesis, sediment transport and hydrodynamics. Our model includes realistic representations of biogeochemical reactions in both seabed and water column, and fluxes at their interface. The model was built on algorithms for seabed-water exchange in the Regional Ocean Modeling System and expanded to include carbonate chemistry in seabed. The updated …

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Financial Impacts Of 2020 Labor Day Wildfires To Oregon Highways, Kevin Christiansen, Rubayet Bin Mostafiz, Ayat Al Assi, Robert V. Rohli, Carol J. Friedland Oct 2024

Financial Impacts Of 2020 Labor Day Wildfires To Oregon Highways, Kevin Christiansen, Rubayet Bin Mostafiz, Ayat Al Assi, Robert V. Rohli, Carol J. Friedland

Faculty Publications

Wildfire-caused damage to highways has a significant financial cost to the local, regional, and state jurisdictions where they occur. This study examines the financial ramifications of the harm caused to highways by megafires, using a case study of the highways impacted in the U.S. state of Oregon by the five megafires that occurred during the 2020 Labor Day wildfires. This study proposes a method to classify financial road damage from these wildfires based upon curated datasets collected from the Oregon Department of Transportation (ODOT). Hence, this study presents a dataset with labeled classes, which include physical, roadway, and traffic. Physical …

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Workplace Bullying In Louisiana Academic Libraries: Exploring Worker Status And Demographics, Justin Savage, Andrea Hebert, Catherine Baird Oct 2024

Workplace Bullying In Louisiana Academic Libraries: Exploring Worker Status And Demographics, Justin Savage, Andrea Hebert, Catherine Baird

Faculty Publications

Bullying is a phenomenon that exists across cultures, societies, and even species. It can be found everywhere, including the workplace. The present study investigates workplace bullying amongst an approximated census sample of Louisiana academic library workers. Using the Negative Acts Questionnaire—Revised (NAQ-R), the study explores the relationships between experiencing workplace bullying and librarian status, tenure status, years in the profession, age, gender, and race. Although no statistically significant relationships were found between variables, the findings add to a growing body of literature that explores the interrelations of demographic and environmental contexts and bullying experiences.

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On The Pathogenesis Of Obesity: Causal Models And Missing Pieces Of The Puzzle, Faidon Magkos, Thorkild I.A. Sørensen, David Raubenheimer, Nikhil V. Dhurandhar, Ruth J.F. Loos, Anja Bosy-Westphal, Christoffer Clemmensen, Mads F. Hjorth, David B. Allison, Gary Taubes, Eric Ravussin, Mark I. Friedman, Kevin D. Hall, David S. Ludwig, John R. Speakman, Arne Astrup Oct 2024

On The Pathogenesis Of Obesity: Causal Models And Missing Pieces Of The Puzzle, Faidon Magkos, Thorkild I.A. Sørensen, David Raubenheimer, Nikhil V. Dhurandhar, Ruth J.F. Loos, Anja Bosy-Westphal, Christoffer Clemmensen, Mads F. Hjorth, David B. Allison, Gary Taubes, Eric Ravussin, Mark I. Friedman, Kevin D. Hall, David S. Ludwig, John R. Speakman, Arne Astrup

Clinical Research Faculty Publications

Application of the physical laws of energy and mass conservation at the whole-body level is not necessarily informative about causal mechanisms of weight gain and the development of obesity. The energy balance model (EBM) and the carbohydrate–insulin model (CIM) are two plausible theories, among several others, attempting to explain why obesity develops within an overall common physiological framework of regulation of human energy metabolism. These models have been used to explain the pathogenesis of obesity in individuals as well as the dramatic increases in the prevalence of obesity worldwide over the past half century. Here, we summarize outcomes of a …

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Four-Year Follow-Up Of Weight Loss Maintenance Using Electronic Medical Record Data: The Propel Trial, Peter T. Katzmarzyk, Emily F. Mire, Ronald Horswell, San T. Chu, Dachuan Zhang, Corby K. Martin, Robert L. Newton, John W. Apolzan, Eboni G. Price-Haywood, Dan Fort, Thomas W. Carton, Kara D. Denstel Oct 2024

Four-Year Follow-Up Of Weight Loss Maintenance Using Electronic Medical Record Data: The Propel Trial, Peter T. Katzmarzyk, Emily F. Mire, Ronald Horswell, San T. Chu, Dachuan Zhang, Corby K. Martin, Robert L. Newton, John W. Apolzan, Eboni G. Price-Haywood, Dan Fort, Thomas W. Carton, Kara D. Denstel

Clinical Research Faculty Publications

Rationale: Short-term weight loss is possible in a variety of settings. However, long-term, free-living weight loss maintenance following structured weight loss interventions remains elusive. Objective: The purpose was to study body weight trajectories over 2 years of intensive lifestyle intervention (ILI) and up to 4 years of follow-up versus usual care (UC). Methods: Data were obtained from electronic medical records (EMRs) from participating clinics. Baseline (Day 0) was established as the EMR data point closest but prior to the baseline date of the trial. The sample included 111 ILI and 196 UC patients. The primary statistical analysis focused on differentiating …

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A New Data-Driven Model To Predict Monthly Runoff At Watershed Scale: Insights From Deep Learning Method Applied In Data-Driven Model, Shunqing Jia, Xihua Wang, Y. Jun Xu, Zejun Liu, Boyang Mao Oct 2024

A New Data-Driven Model To Predict Monthly Runoff At Watershed Scale: Insights From Deep Learning Method Applied In Data-Driven Model, Shunqing Jia, Xihua Wang, Y. Jun Xu, Zejun Liu, Boyang Mao

Faculty Publications

Accurate forecasting of mid to long-term runoff is essential for water resources management. However, the traditional model cannot predict well and the precision of runoff forecast needs to be further improved. Here, we proposed a novel data-driven model aimed at enhancing the performance of the Gated Recurrent Unit (GRU) through the integration of Robust Local Mean Decomposition (RLMD) and the Slime Mould Algorithm (SMA). The objective is to improve mid to long-term runoff prediction in three hydrographic stations: Heishiguan, Baimasi, and Longmenzhen, located within the Yiluo River Watershed in central China. The model leverages monthly runoff data spanning from 2007 …

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Extensions Of Open Science For Applied Behavior Analysis: Preregistration For Single-Case Experimental Designs, Matt Tincani, Shawn P. Gilroy, Art Dowdy Oct 2024

Extensions Of Open Science For Applied Behavior Analysis: Preregistration For Single-Case Experimental Designs, Matt Tincani, Shawn P. Gilroy, Art Dowdy

Faculty Publications

Open science practices are designed to enhance the utility, integrity, and credibility of scientific research. This article highlights how preregistration in open science practice can be leveraged to enhance the rigor and transparency of single-case experimental designs within an applied behavior analysis framework. We provide an overview of the benefits of preregistration including increased transparency, reduced risk of researcher bias, and improved replicability, and we review the specific contexts under which these practices most benefit the proposed framework. We discuss potential concerns with and unique considerations for preregistering experiments that use single-case designs, with practical guidance for researchers who are …

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Precision Interventions Targeting The Maternal Metabolic Milieu For Healthy Pregnancies In Obesity, Alexandra M. Niclou, Hannah E. Cabre, Emily W. Flanagan, Leanne M. Redman Oct 2024

Precision Interventions Targeting The Maternal Metabolic Milieu For Healthy Pregnancies In Obesity, Alexandra M. Niclou, Hannah E. Cabre, Emily W. Flanagan, Leanne M. Redman

Clinical Research Faculty Publications

Purpose of Review: Entering pregnancy with obesity increases the risk of adverse health outcomes for parent and child. As such, research interventions are largely focused on limiting excess gestational weight gain during pregnancy, especially in those with obesity. Yet, while many lifestyle interventions are successful in reducing GWG, few affect pregnancy outcomes. Here we review work targeting the metabolic milieu instead of focusing solely on weight. Recent Findings: Work done in non-pregnant populations suggests that specifically targeting glucose, triglyceride, and leptin levels or inflammatory makers improves the metabolic milieu and overall health. We posit that precision interventions that include strategies …

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Exercise In The Management Of Polycystic Ovary Syndrome: A Position Statement From Exercise And Sports Science Australia, Angelo Sabag, Rhiannon K. Patten, Alba Moreno-Asso, Giorgia E. Colombo, Xela Dafauce Bouzo, Lisa J. Moran, Cheryce Harrison, Maryam Kazemi, Aya Mousa, Chau Tien Tay, Angelica Lindén Hirschberg, Leanne M. Redman, Helena J. Teede Oct 2024

Exercise In The Management Of Polycystic Ovary Syndrome: A Position Statement From Exercise And Sports Science Australia, Angelo Sabag, Rhiannon K. Patten, Alba Moreno-Asso, Giorgia E. Colombo, Xela Dafauce Bouzo, Lisa J. Moran, Cheryce Harrison, Maryam Kazemi, Aya Mousa, Chau Tien Tay, Angelica Lindén Hirschberg, Leanne M. Redman, Helena J. Teede

Clinical Research Faculty Publications

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition amongst females of reproductive age, leading to lifelong cardiometabolic, reproductive, psychological, and dermatologic symptoms as well as a reduced quality of life. Lifestyle interventions, which can include structured exercise programmes delivered by appropriately trained exercise professionals such as clinical exercise physiologists, are considered first-line strategies in PCOS management due to their therapeutic effects on various health outcomes and quality of life. This position statement builds on the 2023 International Evidence-based Guideline for the Assessment and Management of PCOS and describes the role of the exercise professional in the context of …

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From Pre-Clinical Efficacy To Promising Clinical Trials That Delay Type 1 Diabetes, J. Jason Collier, Daniel S. Hsia, Susan J. Burke Oct 2024

From Pre-Clinical Efficacy To Promising Clinical Trials That Delay Type 1 Diabetes, J. Jason Collier, Daniel S. Hsia, Susan J. Burke

Division of Basic Science Faculty Publications

Recent advancements in immunology and islet biology have unveiled remarkable prospects for the postponement of Type 1 diabetes (T1D) through the strategic modulation of the immune system. In this Perspective, we discuss the pharmaceutical strides achieved, traversing from pre-clinical validation to the execution of impactful clinical trials. We begin with the initial investigations involving cyclosporine and glucocorticoids in rodent models, such as the non-obese diabetic (NOD) mouse, which guided early clinical trials. We then discuss the pre-clinical studies using suitable mouse models that eventually led to contemporary clinical trials targeting immune cell functionality and cytokine signaling pathways. Collectively, these discoveries …

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Long-Term Effects Of Climate Change On Juvenile Bull Shark Migratory Patterns, Philip Matich, Jeffrey D. Plumlee, Walter Bubley, Tobey H. Curtis, J. Marcus Drymon, Lindsay L. Mullins, Oliver N. Shipley, Thomas C. Tinhan, Mark R. Fisher Oct 2024

Long-Term Effects Of Climate Change On Juvenile Bull Shark Migratory Patterns, Philip Matich, Jeffrey D. Plumlee, Walter Bubley, Tobey H. Curtis, J. Marcus Drymon, Lindsay L. Mullins, Oliver N. Shipley, Thomas C. Tinhan, Mark R. Fisher

Faculty Publications

Seasonal variability in environmental conditions is a strong determinant of animal migrations, but warming temperatures associated with climate change are anticipated to alter this phenomenon with unknown consequences. We used a 40-year fishery-independent survey to assess how a changing climate has altered the migration timing, duration and first-year survival of juvenile bull sharks (Carcharhinus leucas). From 1982 to 2021, estuaries in the western Gulf of Mexico (Texas) experienced a mean increase of 1.55°C in autumn water temperatures, and delays in autumn cold fronts by ca. 0.5 days per year. Bull shark migrations in more northern estuaries concomitantly changed, with departures …

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Mercury Concentrations In Seaside Sparrows And Marsh Rice Rats Differ Across The Mississippi River Estuary, Andrea Bonisoli-Alquati, Allyson K. Jackson, Collin A. Eagles-Smith, Sydney Moyo, Anna A. Pérez-Umphrey, Michael J. Polito, Allison M. Snider, S. Tyler Williams, Stefan Woltmann, Philip C. Stouffer, Sabrina S. Taylor Oct 2024

Mercury Concentrations In Seaside Sparrows And Marsh Rice Rats Differ Across The Mississippi River Estuary, Andrea Bonisoli-Alquati, Allyson K. Jackson, Collin A. Eagles-Smith, Sydney Moyo, Anna A. Pérez-Umphrey, Michael J. Polito, Allison M. Snider, S. Tyler Williams, Stefan Woltmann, Philip C. Stouffer, Sabrina S. Taylor

Faculty Publications

Mercury (Hg) concentrations and their associated toxicological effects in terrestrial ecosystems of the Gulf of Mexico are largely unknown. Compounding this uncertainty, a large input of organic matter from the 2010 Deepwater Horizon oil spill may have altered Hg cycling and bioaccumulation dynamics. To test this idea, we quantified blood concentrations of total mercury (THg) in Seaside Sparrows (Ammospiza maritima) and Marsh Rice Rats (Oryzomys palustris) in marshes west and east of the Mississippi River in 2015 and 2016. We also tested for a difference in THg concentrations between oiled and non-oiled sites. To address the potential confounding effect of …

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Why Is Religious Attendance Linked To More Anxiety In U.S. South Asians? The Mediating Role Of Congregational Neglect, Samuel Stroope, Blake Victor Kent, Anna Boonin Schachter, Alka M. Kanaya, Alexandra E. Shields Oct 2024

Why Is Religious Attendance Linked To More Anxiety In U.S. South Asians? The Mediating Role Of Congregational Neglect, Samuel Stroope, Blake Victor Kent, Anna Boonin Schachter, Alka M. Kanaya, Alexandra E. Shields

Faculty Publications

Objectives: Previous research has identified a positive association between religious attendance and anxiety in U.S. South Asians. The current study assesses the mediating role of congregational neglect as a potential mechanism explaining this association. Design: Analyses relied on data from the Study on Stress, Spirituality, and Health (SSSH) questionnaire in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study (n = 936), the largest community-based study of health among U.S. South Asians. Analyses were conducted using path analysis and adjusted for a variety of background characteristics. Results: Results confirmed that higher levels of religious service attendance were …

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Deciphering The Genetic Basis Of Salinity Tolerance In A Diverse Panel Of Cultivated And Wild Soybean Accessions By Genome-Wide Association Mapping, Rajat Pruthi, Chanderkant Chaudhary, Sandeep Chapagain, Mostafa Mohamed Elbasuoni Abozaid, Prabhat Rana, Ravi Kiran Reddy Kondi, Roberto Fritsche-Neto, Prasanta K. Subudhi Oct 2024

Deciphering The Genetic Basis Of Salinity Tolerance In A Diverse Panel Of Cultivated And Wild Soybean Accessions By Genome-Wide Association Mapping, Rajat Pruthi, Chanderkant Chaudhary, Sandeep Chapagain, Mostafa Mohamed Elbasuoni Abozaid, Prabhat Rana, Ravi Kiran Reddy Kondi, Roberto Fritsche-Neto, Prasanta K. Subudhi

Faculty Publications

Key message : In a genome-wide association study involving 269 cultivated and wild soybean accessions, potential salt tolerance donors were identified along with significant markers and candidate genes, such as GmKUP6 and GmWRKY33. Abstract : Salt stress remains a significant challenge in agricultural systems, notably impacting soybean productivity worldwide. A comprehensive genome-wide association study (GWAS) was conducted to elucidate the genetic underpinnings of salt tolerance and identify novel source of salt tolerance among soybean genotypes. A diverse panel comprising 269 wild and cultivated soybean accessions was subjected to saline stress under controlled greenhouse conditions. Phenotypic data revealed that salt tolerance …

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Brain Insulin Signaling Is Associated With Late-Life Cognitive Decline, Han Tong, Ana W. Capuano, Owen T. Carmichael, Kathryn L. Gwizdala, David A. Bennett, Rexford S. Ahima, Steven E. Arnold, Zoe Arvanitakis Oct 2024

Brain Insulin Signaling Is Associated With Late-Life Cognitive Decline, Han Tong, Ana W. Capuano, Owen T. Carmichael, Kathryn L. Gwizdala, David A. Bennett, Rexford S. Ahima, Steven E. Arnold, Zoe Arvanitakis

Clinical Research Faculty Publications

Type-2 diabetes is associated with an increased risk of dementia, and the underlying mechanism might involve abnormal insulin signaling in the brain. The objective of this study was to examine the association of postmortem brain insulin signaling with late-life cognitive decline. Among participants of Religious Orders Study, a community-based clinical-pathological cohort, 150 deceased and autopsied older individuals (75 with diabetes matched to 75 without by age at death, sex, and education) had postmortem brain insulin signaling measurements collected in the prefrontal cortex using ELISA and immunohistochemistry. By using adjusted linear mixed-effects models, we examined the association of postmortem brain insulin …

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Health Literacy Directed Weight Loss Intervention In Primary Care Clinics, Terry Davis, Connie Arnold, Dachuan Zhang, Corby K. Martin, Robert L. Newton, Candice Myers, Kara D. Denstel, Emily F. Mire, Christoph Höchsmann, John Apolzan, Peter T. Katzmarzyk Oct 2024

Health Literacy Directed Weight Loss Intervention In Primary Care Clinics, Terry Davis, Connie Arnold, Dachuan Zhang, Corby K. Martin, Robert L. Newton, Candice Myers, Kara D. Denstel, Emily F. Mire, Christoph Höchsmann, John Apolzan, Peter T. Katzmarzyk

Clinical Research Faculty Publications

BACKGROUND: Low income and low health literacy are associated with poorer health knowledge, health behaviors and poor health outcomes. The effectiveness of health literacy-directed weight loss treatment interventions in primary care clinics is lacking. OBJECTIVE: The aim of this study was to conduct a pragmatic cluster-randomized trial (PROmoting Successful Weight Loss in Primary CarE in Louisiana ([PROPEL]) to test the effectiveness of a 24-month, patient-centered, literacy-directed obesity treatment program delivered within primary care in an underserved population. This study reports the association between health literacy and program effectiveness, examining potential correlates of weight loss related to patient adherence to the …

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When Old Meets New: Two Louisiana State University Outreach Librarians Build, Work, And Learn Together To Support Collaborative Student Engagement, Alia Kempton, Mitch Fontenot Oct 2024

When Old Meets New: Two Louisiana State University Outreach Librarians Build, Work, And Learn Together To Support Collaborative Student Engagement, Alia Kempton, Mitch Fontenot

Faculty Publications

No abstract provided.

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Scintillation Light In Sbnd: Simulation, Reconstruction, And Expected Performance Of The Photon Detection System, C. Zhang, J. Zennamo, B. Zamorano, J. Yu, B. Yu, L. Yates, T. Yang, E. Yandel, S. Yadav, M. Worcester, E. Worcester, T. Wongjirad, P. Wilson, A. Wilkinson, A. White, T. Wester, H. Wei, M. Weber, L. Wan, A. Vázquez-Ramos, R. G. Van De Water, G. A. Valdiviesso, L. Tung, C. Touramanis, M. Toups, D. Totani, A. M. Szelc, T. Strauss, G. V. Stenico, M. Stancari, N. J.C. Spooner, J. Spitz, S. Söldner-Rembold Oct 2024

Scintillation Light In Sbnd: Simulation, Reconstruction, And Expected Performance Of The Photon Detection System, C. Zhang, J. Zennamo, B. Zamorano, J. Yu, B. Yu, L. Yates, T. Yang, E. Yandel, S. Yadav, M. Worcester, E. Worcester, T. Wongjirad, P. Wilson, A. Wilkinson, A. White, T. Wester, H. Wei, M. Weber, L. Wan, A. Vázquez-Ramos, R. G. Van De Water, G. A. Valdiviesso, L. Tung, C. Touramanis, M. Toups, D. Totani, A. M. Szelc, T. Strauss, G. V. Stenico, M. Stancari, N. J.C. Spooner, J. Spitz, S. Söldner-Rembold

Faculty Publications

SBND is the near detector of the Short-Baseline Neutrino program at Fermilab. Its location near to the Booster Neutrino Beam source and relatively large mass will allow the study of neutrino interactions on argon with unprecedented statistics. This paper describes the expected performance of the SBND photon detection system, using a simulated sample of beam neutrinos and cosmogenic particles. Its design is a dual readout concept combining a system of 120 photomultiplier tubes, used for triggering, with a system of 192 X-ARAPUCA devices, located behind the anode wire planes. Furthermore, covering the cathode plane with highly-reflective panels coated with a …

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A Quantitative Adverse Outcome Pathway For Embryonic Activation Of The Aryl Hydrocarbon Receptor Of Fishes By Polycyclic Aromatic Hydrocarbons Leading To Decreased Fecundity At Adulthood, Jon A. Doering, Justin Dubiel, Eric Stock, Cameron H. Collins, Ian Frick, Hunter M. Johnson, Christopher M. Lowrey-Dufour, Justin G.P. Miller, Zhe Xia, Gregg T. Tomy, Steve Wiseman Oct 2024

A Quantitative Adverse Outcome Pathway For Embryonic Activation Of The Aryl Hydrocarbon Receptor Of Fishes By Polycyclic Aromatic Hydrocarbons Leading To Decreased Fecundity At Adulthood, Jon A. Doering, Justin Dubiel, Eric Stock, Cameron H. Collins, Ian Frick, Hunter M. Johnson, Christopher M. Lowrey-Dufour, Justin G.P. Miller, Zhe Xia, Gregg T. Tomy, Steve Wiseman

Faculty Publications

Quantitative adverse outcome pathways (qAOPs) describe the response–response relationships that link the magnitude and/or duration of chemical interaction with a specific molecular target to the probability and/or severity of the resulting apical-level toxicity of regulatory relevance. The present study developed the first qAOP for latent toxicities showing that early life exposure adversely affects health at adulthood. Specifically, a qAOP for embryonic activation of the aryl hydrocarbon receptor 2 (AHR2) of fishes by polycyclic aromatic hydrocarbons (PAHs) leading to decreased fecundity of females at adulthood was developed by building on existing qAOPs for (1) activation of the AHR leading to early …

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Insurance Coverage And Flood Exposure In The Gulf Of Mexico: Scale, Social Vulnerability, Urban Form, And Risk Measures, Anissa Hyde, Robert Habans, Mariam Valladares-Castellanos, Thomas Douthat Oct 2024

Insurance Coverage And Flood Exposure In The Gulf Of Mexico: Scale, Social Vulnerability, Urban Form, And Risk Measures, Anissa Hyde, Robert Habans, Mariam Valladares-Castellanos, Thomas Douthat

Faculty Publications

Increasing flood losses in the Gulf of Mexico related to development patterns and climate hazards pose serious threats to resilience and insurability. The purpose of this study is to understand how scale, social vulnerability, risk, and urban form relate to National Flood Insurance Program (NFIP) policy coverage and flood exposure. Our multilevel models identify that flooding is significantly clustered by region and counties, especially shoreline counties. Our measures of risk suggest that the Federal Emergency Management Agency (FEMA) special flood hazard area (SFHA) underestimates risk and exposure when compared with the Flood Factor and that there is some compensation in …

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Prescribed Fire Regimes Influence Responses Of Fungal And Bacterial Communities On New Litter Substrates In A Brackish Tidal Marsh, Viet Q. Dao, Crystal N. Johnson, William J. Platt Oct 2024

Prescribed Fire Regimes Influence Responses Of Fungal And Bacterial Communities On New Litter Substrates In A Brackish Tidal Marsh, Viet Q. Dao, Crystal N. Johnson, William J. Platt

Faculty Publications

Processes modifying newly deposited litter substrates should affect fine fuels in fire-managed tidal marsh ecosystems. Differences in chemical composition and dynamics of litter should arise from fire histories that generate pyrodiverse plant communities, tropical cyclones that deposit wrack as litter, tidal inundation that introduces and alters sediments and microbes, and interactions among these different processes. The resulting diversity and dynamics of available litter compounds should affect microbial (fungal and bacterial) communities and their roles in litter substrate dynamics and ecosystem responses over time. We experimentally examined effects of differences in litter types produced by different fire regimes and litter loads …

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Bimetallic Catalyst System For The Degradation Of Pcbs In Sediments, Balamurugan Subramanian, Dean Lay, Souhail R. Al-Abed, John L. Mckernan, Slawomir Lomnicki Oct 2024

Bimetallic Catalyst System For The Degradation Of Pcbs In Sediments, Balamurugan Subramanian, Dean Lay, Souhail R. Al-Abed, John L. Mckernan, Slawomir Lomnicki

Faculty Publications

In this paper, we report the successful application of a patent-pending reduced bimetallic nanoparticle catalytic system developed for the remediation of polychlorinated biphenyl (PCB)-contaminated sediment and aquatic media. The formation of bimetallic nanoparticles associated with the granular activated carbon (GAC) were confirmed by high-resolution transmission electron microscopy. X-ray photoelectron spectroscopy showed the presence of the bimetallic matrix in reduced, albeit mixed, states. In the degradation studies, the bimetallic nanoparticles were deposited on a GAC substrate and utilized to treat both a surrogate PCB, 2-Chlorobiphenyl (2-CBP) in water and contaminated bottom-river sediments collected from a site with mixed-congener PCB contamination. The …

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Math Performance In East Baton Rouge Parish Schools: 2023-2024, 5th-8th Grades, H. Colleen Sinclair, Judith L. F. Rhodes, Stacey R. Terrio Oct 2024

Math Performance In East Baton Rouge Parish Schools: 2023-2024, 5th-8th Grades, H. Colleen Sinclair, Judith L. F. Rhodes, Stacey R. Terrio

Reports

This report examines the effects of a digital learning platform and individual students' self-reported motivations on math performance, namely 9-week grades and annual state assessments, among 5th through 8th graders in a large school system in the Louisiana. The findings are based on data collected as part of a research-practitioner partnership funded by the Gates Foundation. The report shows how key motivational factors (e.g., confidence, anxiety), digital learning use, and student characteristics were related to math performance. These results help identify possible avenues for targeted interventions to improve confidence and reduce fears, for example, to help students in their math …

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Analysis Of Crab X-Ray Polarization Using Deeper Imaging X-Ray Polarimetry Explorer Observations, Josephine Wong, Tsunefumi Mizuno, Niccoló Bucciantini, Roger W. Romani, Yi Jung Yang, Kuan Liu, Wei Deng, Kazuho Goya, Fei Xie, Maura Pilia, Philip Kaaret, Martin C. Weisskopf, Stefano Silvestri, C. Y. Ng, Chien Ting Chen, Iván Agudo, Lucio A. Antonelli, Matteo Bachetti, Luca Baldini, Wayne H. Baumgartner, Ronaldo Bellazzini, Stefano Bianchi, Stephen D. Bongiorno, Raffaella Bonino, Alessandro Brez, Fiamma Capitanio, Simone Castellano, Elisabetta Cavazzuti, Stefano Ciprini, Enrico Costa, Alessandra De Rosa, Ettore Del Monte, Laura Di Gesu Oct 2024

Analysis Of Crab X-Ray Polarization Using Deeper Imaging X-Ray Polarimetry Explorer Observations, Josephine Wong, Tsunefumi Mizuno, Niccoló Bucciantini, Roger W. Romani, Yi Jung Yang, Kuan Liu, Wei Deng, Kazuho Goya, Fei Xie, Maura Pilia, Philip Kaaret, Martin C. Weisskopf, Stefano Silvestri, C. Y. Ng, Chien Ting Chen, Iván Agudo, Lucio A. Antonelli, Matteo Bachetti, Luca Baldini, Wayne H. Baumgartner, Ronaldo Bellazzini, Stefano Bianchi, Stephen D. Bongiorno, Raffaella Bonino, Alessandro Brez, Fiamma Capitanio, Simone Castellano, Elisabetta Cavazzuti, Stefano Ciprini, Enrico Costa, Alessandra De Rosa, Ettore Del Monte, Laura Di Gesu

Faculty Publications

We present Crab X-ray polarization measurements using Imaging X-Ray Polarimetry Explorer (IXPE) data with a total exposure of 300 ks, three times more than the initial 2022 discovery paper. Polarization is detected in three times more pulsar phase bins, revealing an S-shaped +40° polarization angle sweep in the main pulse and >1σ departures from the OPTIMA optical polarization in both pulses, suggesting different radiation mechanisms or sites for the polarized emission at the two wavebands. Our polarization map of the inner nebula reveals a toroidal magnetic field, as seen in prior IXPE analyses. Along the southern jet, the magnetic field …

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Coupling And Recoupling Coefficients For Wigner’S U(4) Supermultiplet Symmetry, Phong Dang, Jerry P. Draayer, Feng Pan, Tomáš Dytrych, Daniel Langr, David Kekejian, Kevin S. Becker, Noah Thompson Oct 2024

Coupling And Recoupling Coefficients For Wigner’S U(4) Supermultiplet Symmetry, Phong Dang, Jerry P. Draayer, Feng Pan, Tomáš Dytrych, Daniel Langr, David Kekejian, Kevin S. Becker, Noah Thompson

Faculty Publications

A novel procedure for evaluating Wigner coupling coefficients and Racah recoupling coefficients for U(4) in two group–subgroup chains is presented. The canonical U(4)⊃U(3)⊃U(2)⊃U(1) coupling and recoupling coefficients are applicable to any system that possesses U(4) symmetry, while the physical U(4)⊃SUS(2)⊗SUT(2) coupling coefficients are more specific to nuclear structure studies that utilize Wigner’s supermultiplet symmetry concept. The procedure that is proposed sidesteps the use of binomial coefficients and alternating sum series and consequently enables fast and accurate computation of any and all U(4)-underpinned features. The inner multiplicity of a (S, T) pair within a single U(4) irreducible representation is obtained from …

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