Digital Commons Network^™

The Design, Construction, And Testing Of Nucleic Acid Vaccines Against Salmonella Enterica Subspecies Enterica Serovar Javiana, Alexis A. Nguyen

LSU Master's Theses

Salmonella spp. is a Gram-negative bacterium that has the ability to replicate within a variety of hosts, or within the environment, including water, soil, and vegetation. These characteristics, coupled with the zoonotic nature of non-typhoidal Salmonella, pose a significant public health concern. Salmonella is the leading cause of foodborne illnesses worldwide, and in the United States alone, the economic impact due to non-typhoidal Salmonella illnesses in 2013 was estimated to be $3.7 billion, the majority of which were due to mortalities. In a time of rising antibiotic resistance, antibiotics are no longer considered the most effective treatment for …

A Roadmap To The Next-Generation Technology-Enabled Learning-Centered Environments In Aec Education, Yimin Zhu, Amirhosein Jafari, Amir H. Behzadan, Raja R.A. Issa

Faculty Publications

The architecture, engineering, and construction (AEC) education communities are increasingly facing challenges caused by social, technological, economic, environmental, and political changes. Addressing these issues requires AEC educators and practitioners to systematically rethink and reform many of their current practices. Anecdotal evidence in AEC education already exists with respect to pedagogical improvements made by individual technologies such as immersive computing, artificial intelligence, robotics, big data, cyberinfrastructure, and photogrammetry. However, an effective learning-centered environment is more complex than what any single technology can accomplish. In addition, the relationship between technology-intensive learning and digital inequity in AEC education remains, to the most extent, …

Louisiana Agriculture Magazine, Summer 2024, Lsu Agcenter

Louisiana Agriculture

When the first agricultural experiment stations were founded in Louisiana more than 130 years ago, researchers focused on ways to improve the lives of farmers across the state. They found the best methods for raising cash crops and livestock along with the fruits and vegetables grown to feed the average rural family. Today the LSU AgCenter maintains that long legacy of research and expands its scope.

This issue of Louisiana Agriculture acknowledges those who helped establish the system of research and extension that would grow into the AgCenter. In addition to these articles, the scientists and staff at the AgCenter …

Isocaloric Replacement Of Ultraprocessed Foods Was Associated With Greater Weight Loss In The Pounds Lost Trial, Qisi Yao, Carolina D. De Araujo, Filippa Juul, Catherine M. Champagne, George A. Bray, Frank M. Sacks, Maya K. Vadiveloo

Population and Public Health Science Faculty Publications

Objective: Higher intake of ultraprocessed foods (UPFs) is associated with obesity. We examined whether replacing UPFs (NOVA 4) with minimally processed foods and culinary ingredients (NOVA 1 + 2) was associated with differential weight change in this secondary prospective analysis of the Preventing Overweight Using Novel Dietary Strategies (POUNDS) Lost trial. Methods: We estimated percent energy intake (%kcal) from the four NOVA groups using 24-h dietary recalls in a subset of 356 participants. Multivariable-adjusted substitution models examined whether replacing %kcal from UPFs with NOVA 1 + 2 was associated with greater weight, body fat percentage, trunk fat, and waist circumference …

A Systematic Review On The Path To Inclusive And Sustainable Energy Transitions, Oluwafemi Awolesi, Corinne A. Salter, Margaret Reams

Faculty Publications

This paper surveys the energy literature and systematically reviews the path to an inclusive and sustainable energy transition by exploring factors that drive the current energy transitions, countries with advanced energy transition programs, and the roles of energy literacy and justice in energy transition. Utilizing an exhaustive literature search from 2001 to 2023 via the Scopus database, the study identifies strong policy frameworks, technological advancements, economic incentives, and international collaborations as pivotal factors in successful energy transitions. Case studies from the Nordic countries, Germany, and Poland highlight diverse approaches and significant progress, revealing valuable lessons for global application. Although energy …

An Ixpe-Led X-Ray Spectropolarimetric Campaign On The Soft State Of Cygnus X-1: X-Ray Polarimetric Evidence For Strong Gravitational Lensing, James F. Steiner, Edward Nathan, Kun Hu, Henric Krawczynski, Michal Dovčiak, Alexandra Veledina, Fabio Muleri, Jiri Svoboda, Kevin Alabarta, Maxime Parra, Yash Bhargava, Giorgio Matt, Juri Poutanen, Pierre Olivier Petrucci, Allyn F. Tennant, M. Cristina Baglio, Luca Baldini, Samuel Barnier, Sudip Bhattacharyya, Stefano Bianchi, Maimouna Brigitte, Mauricio Cabezas, Floriane Cangemi, Fiamma Capitanio, Jacob Casey, Nicole Rodriguez Cavero, Simone Castellano, Elisabetta Cavazzuti, Sohee Chun, Eugene Churazov, Enrico Costa, Niccolò Di Lalla, Alessandro Di Marco

Faculty Publications

We present the first X-ray spectropolarimetric results for Cygnus X-1 in its soft state from a campaign of five IXPE observations conducted during 2023 May-June. Companion multiwavelength data during the campaign are likewise shown. The 2-8 keV X-rays exhibit a net polarization degree PD = 1.99% ± 0.13% (68% confidence). The polarization signal is found to increase with energy across the Imaging X-ray Polarimetry Explorer’s (IXPE) 2-8 keV bandpass. The polarized X-rays exhibit an energy-independent polarization angle of PA = −25.°7 ± 1.°8 east of north (68% confidence). This is consistent with being aligned to Cyg X-1’s au-scale compact radio …

Secondary School State Athletic Association Health And Safety Policy Development Processes, Susan Yeargin, Rebecca M. Hirschhorn, William M. Adams, Samantha E. Scarneo-Miller

Faculty Publications

Background: The National Federation of State High School Associations provides recommendations regarding health and safety policies; however, policy development is governed at the state level. Given interstate differences in governance, the primary purpose was to describe processes that State High School Athletic Associations (SHSAAs) utilize to develop a new policy. The secondary objective was to determine what methods associations use to implement new policies. Methods: A cross-sectional survey requested SHSAA (n = 51) representatives to report how athlete health and safety policies are introduced, revised, approved, and implemented within their state. The 22-question survey was developed to gather variables for …

A (Dynamic) Investigation Of Stereotypes, Belief-Updating, And Behavior, Katherine Coffman, Maria Paola Ugalde Araya, Basit Zafar

Faculty Publications

Using a controlled experiment, we study the dynamic effects of feedback on decision-making across verbal skills and math. Before feedback, men are more optimistic about their performance and more willing to compete than women, especially in math. While feedback shifts individuals' beliefs and behavior, we see substantial persistence of gender gaps 1 week later. This is particularly true among individuals who receive negative feedback. Our results are not well-explained by motivated reasoning; in fact, negative feedback is more likely to be recalled than positive feedback. Overall, our results highlight the challenges involved in overcoming gender gaps in dynamic settings.

Water-Limited Hydrothermalism And Volcanic Resurfacing Of Eridania Basin, Mars, Emmy B. Hughes, James Wray, Suniti Karunatillake, Grace Fanson, Elise Harrington, Don R. Hood

Faculty Publications

The Eridania Basin system, located in the martian southern highlands, may have hosted long-lived lacustrine hydrothermalism. Despite its multi-basin scale and suggested longevity that should pervasively alter the landscape, evidence for consistent compositional signatures of lacustrine hydrothermalism across varying spatial scales is poorly known. Here we synthesize orbital data sets (derived from the Gamma Ray Spectrometer, GRS; Thermal Emission Spectrometer, TES; and Compact Reconnaissance Imaging Spectrometer for Mars, CRISM) to characterize the composition of Eridania's landscape from regional to outcrop scales. The bulk geochemistry representing decimeter depths is broadly on par with mafic igneous compositions seen elsewhere on Mars. The …

Improving Asphalt Binder Durability Using Sustainable Materials: A Rheological And Chemical Analysis Of Polymer-, Rubber-, And Epoxy-Modified Asphalt Binders, Anas Abualia, Moses Akentuna, Louay N. Mohammad, Samuel B. Cooper, Samuel B. Cooper

Faculty Publications

When exposed to sun radiation and heat, asphalt binders age, resulting in reduced flexibility, cracking, and pavement failure. Given the increasing demands of traffic, environmental concerns, and resource scarcity, highway agencies and researchers are actively seeking solutions that meet performance requirements and demonstrate awareness of using non-renewable resources. Epoxy asphalt (EA) promotes sustainability concepts due to its production at significantly lower mixing and compaction temperatures, enhanced durability, improved serviceability, reduced maintenance needs, and successful recycling and reuse in hot asphalt mixtures. Crumb rubber, a widely recognized recycled waste tire material, is considered a viable option for promoting sustainability and enhancing …

A Review Of The Rheological Consistency Of Materials, Alan Gurt, Michael Khonsari

Faculty Publications

Despite the ubiquity and prevalence of rheological consistency across a wide range of industries, there is no clear consensus on its meaning or on one particular technique for quantifying it. Instead, there exist various definitions of “consistency” that are each specific to a given context, and each industry has its own procedure for measuring it. This paper organizes the many subjects and terminologies associated with consistency, providing a comprehensive guide of fundamental mechanics, fundamental properties, modeling techniques, and standardized tests that describe consistency. This includes outlining the rheological models that describe the behavior of viscoelastic and non-Newtonian materials as well …

Academic Support Programs At Hbcu Law Schools, Marla L. Dickerson

LSU Doctoral Dissertations

This qualitative descriptive case study delves into the effectiveness of academic support programs (ASPs) for students at Historically Black Colleges and Universities (HBCU) law schools, focusing on enhancing academic performance and passing the bar exam. The underrepresentation of minority lawyers in the United States, which is attributed partly to standardized test disparities, underscores the need for tailored support mechanisms. Drawing from social cognitive theory (SCT), the study investigates how ASPs impact academic success, informed by participant interviews and thematic analysis.

Key findings reveal four prominent themes. Firstly, effective features of ASPs for promoting academic performance include personalized guidance from academic …

Családi, Joelle Nagy

LSU Master's Theses

Családi (Magyar/Hungarian) adjective: related to the family; related to the home

CSALÁDI is a compendium of paintings and sculpture that narrate and itemize memories, mementos, and feelings from my childhood in relation to the home. It is an autobiographical agglomeration of objects and spaces that I am honoring and remembering through the act of creating. I am effectuating the feminine and maternal instinct of gathering and arranging my memories pertaining to personal history and inherited cultural identity through altar-making. Idiosyncratic items are collected and bound through color association and sensory memory. Constructing interior and exterior spaces of the home in …

Consumer Behavior Analysis Approach To Teacher Choice Of Reading Interventions, Rochelle N. Picardo

LSU Doctoral Dissertations

The use of Evidence-based Practices (EBPs) in schools is heavily emphasized in educational research and policy; however, many teachers do not use EBPs for reading instruction and intervention. Previous research on the limited use of EBPs in classrooms has primarily focused on teacher characteristics, such as their attitudes or beliefs toward these practices. As an alternative to this view, this study applied a behavioral economic approach to understanding teacher choice (i.e., EBPs over other alternatives, such as interventions with a base of limited empirical support; low-value practices [LVPs]). Hypothetical Intervention Choice Tasks were developed and used to evaluate how both …

Improving School Discipline, Climate, And Culture: Interactive Guidance For Schools And Districts, Gwendolyn Murray

Reports

This interactive guide is designed to support K-12 school districts and schools to proactively improve school environments by supporting teacher development and building systems to promote positive student behaviors. Practices and strategies in the guide can be used to reduce exclusionary discipline and improve school climate and culture. Activities enable users to think critically about school discipline and invest in data-driven and prevention-oriented systems to address students' challenging and problematic behaviors.

Inhalation Of Particulate Matter Containing Environmentally Persistent Free Radicals Induces Endothelial Dysfunction Mediated Via Ahr Activation At The Air-Blood Interface, Ankit Aryal, Ashlyn C. Harmon, Kurt J. Varner, Alexandra Noël, Stephania A. Cormier, Divine B. Nde, Peter Mottram, Jemiah Maxie, Tammy R. Dugas

Division of Basic Science Faculty Publications

Particulate matter (PM) containing environmentally persistent free radicals (EPFR) is formed by the incomplete combustion of organic wastes, resulting in the chemisorption of pollutants to the surface of PM containing redox-Active transition metals. In prior studies in mice, EPFR inhalation impaired endothelium-dependent vasodilation. These findings were associated with aryl hydrocarbon receptor (AhR) activation in the alveolar type-II (AT-II) cells that form the air-blood interface in the lung. We thus hypothesized that AhR activation in AT-II cells promotes the systemic release of mediators that promote endothelium dysfunction peripheral to the lung. To test our hypothesis, we knocked down AhR in AT-II …

Phytochemical Profiling And Bioactive Potential Of Grape Seed Extract In Enhancing Salinity Tolerance Of Vicia Faba, Doaa E. Elsherif, Fatmah A. Safhi, Prasanta K. Subudhi, Abdelghany S. Shaban, Mai A. El-Esawy, Asmaa M. Khalifa

Faculty Publications

Salinity stress poses a significant threat to crop productivity worldwide, necessitating effective mitigation strategies. This study investigated the phytochemical composition and potential of grape seed extract (GSE) to mitigate salinity stress effects on faba bean plants. GC–MS analysis revealed several bioactive components in GSE, predominantly fatty acids. GSE was rich in essential nutrients and possessed a high antioxidant capacity. After 14 days of germination, GSE was applied as a foliar spray at different concentrations (0, 2, 4, 6, and 8 g/L) to mitigate the negative effects of salt stress (150 mM NaCl) on faba bean plants. Foliar application of 2–8 …

Completing The Ba–As Compositional Space: Synthesis And Characterization Of Three New Binary Zintl Arsenides, Ba3as4, Ba5as4, And Ba16as11, Spencer R. Watts, Lindsey M. Wingate, Svilen Bobev, Sviatoslav Baranets

Faculty Publications

Three novel binary barium arsenides, Ba3As4, Ba5As4, and Ba16As11, were synthesized and their crystal and electronic structures were investigated. Structural data collected via the single-crystal X-ray diffraction method indicate that the anionic substructures of all three novel compounds are composed of structural motifs based on the homoatomic As–As contacts, with [As2]⁴⁻ dimers found in Ba5As4 and Ba16As11, and an [As4]⁶⁻ tetramer found in Ba3As4. Ba3As4 and Ba5As4 crystallize in the orthorhombic crystal system—with the non-centrosymmetric space group Fdd2 (a = 15.3680(20) Å, b = 18.7550(30) Å, c = 6.2816(10) Å) for the former, and the centrosymmetric space group …

Targeting Cancers With Ohsv-Based Oncolytic Viral Immunotherapy, Rakin Tammam Nasar, Ifeanyi Kingsley Uche, Konstantin G. Kousoulas

Faculty Publications

The recent success of cancer immunotherapies, such as immune checkpoint inhibitor (ICIs), monoclonal antibodies (mAbs), cancer vaccines, and adoptive cellular therapies (ACTs), has revolutionized traditional cancer treatment. However, these immunotherapeutic modalities have variable efficacies, and many of them exhibit adverse effects. Oncolytic viral Immunotherapy (OViT), whereby viruses are used to directly or indirectly induce anti-cancer immune responses, is emerging as a novel immunotherapy for treating patients with different types of cancer. The herpes simplex virus type-1 (HSV-1) possesses many characteristics that inform its use as an effective OViT agents and remains a leading candidate. Its recent clinical success resulted in …

Stacked Noise Reduction Auto Encoder–Ocean: A Novel Personalized Recommendation Model Enhanced, Bixi Wang, Wenfeng Zheng, Ruiyang Wang, Siyu Lu, Lirong Yin, Lei Wang, Zhengtong Yin, Xinbing Chen

Faculty Publications

With the continuous development of information technology and the rapid increase in new users of social networking sites, recommendation technology is becoming more and more important. After research, it was found that the behavior of users on social networking sites has a great correlation with their personalities. The five characteristics of the OCEAN personality model can cover all aspects of a user’s personality. In this research, a micro-directional propagation model based on the OCEAN personality model and a Stacked Denoising Auto Encoder (SDAE) was built through the application of deep learning to a collaborative filtering technique. Firstly, the dimension of …

Hydrometeorological Drivers Of The 2023 Louisiana Water Crisis, P. W. Miller, M. Hiatt

Faculty Publications

During summer and fall 2023, Louisiana experienced a historic local drought while dry conditions elsewhere in the central US withheld vital runoff from the Mississippi River, leading to below-normal discharge into the Gulf of Mexico. Thus, by late October 2023, Louisiana was gripped by two super-imposed water crises: a severe local drought and saltwater contamination in the Mississippi River channel. This study frames the development of the water emergency through the lens of flash drought using the Evaporative Demand Drought Index (EDDI). The EDDI shows south Louisiana experience a flash drought during June 2023, while the Mississippi River basin was …

Complexity Of Avian Evolution Revealed By Family-Level Genomes, Josefin Stiller, Shaohong Feng, Al Aabid Chowdhury, Iker Rivas-González, David A. Duchêne, Qi Fang, Yuan Deng, Alexey Kozlov, Alexandros Stamatakis, Santiago Claramunt, Jacqueline M.T. Nguyen, Simon Y.W. Ho, Brant C. Faircloth, Julia Haag, Peter Houde, Joel Cracraft, Metin Balaban, Uyen Mai, Guangji Chen, Rongsheng Gao, Chengran Zhou, Yulong Xie, Zijian Huang, Zhen Cao, Zhi Yan, Huw A. Ogilvie, Luay Nakhleh, Bent Lindow, Benoit Morel, Jon Fjeldså, Peter A. Hosner, Rute R. Da Fonseca, Bent Petersen

Faculty Publications

Despite tremendous efforts in the past decades, relationships among main avian lineages remain heavily debated without a clear resolution. Discrepancies have been attributed to diversity of species sampled, phylogenetic method and the choice of genomic regions^1–3. Here we address these issues by analysing the genomes of 363 bird species⁴ (218 taxonomic families, 92% of total). Using intergenic regions and coalescent methods, we present a well-supported tree but also a marked degree of discordance. The tree confirms that Neoaves experienced rapid radiation at or near the Cretaceous–Palaeogene boundary. Sufficient loci rather than extensive taxon sampling were more effective …

The Effect Of A Lactobacillus Containing Gel On The Clitoral Microbiome Of The Mare, Fiona E. Herzog

LSU Master's Theses

The equine lower reproductive tract harbors bacterial populations that serve as a reservoir for potential pathogens. Dysbiosis of urogenital sites may play a role in reproductive disease of the mare, including endometritis. Metagenetic studies have evaluated microbiomes in the uterus, vagina and placenta, while the clitoral microbiome has yet to be described. In this study, the following hypotheses were tested; 1) the clitoris harbors a unique microbiome, 2) topical Lactobacillus genus complex (LGC) probiotic will alter this microbiome, 3) acceptable per cycle pregnancy rates (PCPR) following probiotic application will be achieved. Reproductively normal mares (n=14) were selected, and clitoral fossa …

It’S Britney, Bitch, Mary Hyepock

LSU Doctoral Dissertations

This dissertation engages public rhetorics surrounding pop princess Britney Spears as a case study for examining the rhetoricity of bodily autonomy. Bodily autonomy is commonly understood as the legal right to control what happens to one’s body without external influence or coercion. However, one’s legal access to bodily autonomy is produced, negotiated, and maintained through discourse. In other words, one’s access to so-called “ownership” over their body and agency to make decisions about it is deeply tied to the gendered and racialized symbolic production of citizenship in the United States. Utilizing a reproductive justice framework, I investigate how Britney Spears’ …

Vibrato Rate And Extent In The Baritone Voice Through The Twentieth And Early Twenty-First Century, Scott Purcell

LSU Doctoral Dissertations

Observations of vibrato rate and extent through the twentieth and early twenty-first century point to an overall decrease in rate and increase in extent. This descriptive analysis studied fifty-five randomly selected recordings of professional operatic baritones, five from each decade from 1910 to 2021, and analyzed their vibrato rate and extent with VoceVista Video Pro. Results showed a consistent decrease in mean vibrato rate from 1910 to 1960, with small increases and decreases from 1960-2021. Vibrato extent was less consistent, but still increased from 1910-2021. The mean vibrato rate was 5.84 Herz (Hz), with a coefficient of variation (CV) of …

An Analysis Of The Musical Gestures In Osvaldo Golijov’S The Dreams And Prayers Of Isaac The Blind And Their Relationship To The Kabbalah Sefirot, Jeremy Gdaniec

LSU Doctoral Dissertations

Osvlado Golijov’s The Dreams and Prayers of Isaac the Blind, scored for klezmer clarinet and string quartet, remains one of his most influential works since its premier in 1994. Inspiration for the work came from the writings of Rabbi Isaac the Blind, a prominent 13^th century figurehead in the branch of Jewish mysticism known as Kabbalah. In Kabbalah, symbols known as the sefirot are emanations of creation and the key to unlocking the divine secrets of the God-head. The analysis presented in this document combines musical gesture theory with Kabbalistic concepts for new perspectives on Golijov’s …

Examining The Authenticity Of The 'Ether Model' In Certain O-Glycosylation Reactions, Varad Vinayak Agarkar

LSU Doctoral Dissertations

Acinetobacter baumannii is a gram-negative bacterium species that is responsible for nosocomial infections. It has shown antibiotic resistance and has been designated an urgent threat by the CDC. In Chapter 1, I highlight my efforts in the synthesis of a Kdo building block in the journey towards the construction of an A. baumannii lipooligosaccharide (LOS) core pentasaccharide- a potential candidate for glycoconjugate vaccine against A. baumannii infection. I talk about various optimizations and improvements in the Kdo monosaccharide synthesis and the mechanistic insights I provided about a critical transformation in the synthetic sequence.

Chemical O-glycosylation is a significant research …

Exploratory Physiological Experiments Are Not Clinical Trials, Erik A. Richter, David E. James, John P. Kirwan, Juleen R. Zierath

Division of Basic Science Faculty Publications

No abstract provided.

Multiphoton Quantum Sensing, Fatemeh Mostafavikhatam

LSU Doctoral Dissertations

While the fundamental principles of light-matter interaction are well-understood and drive countless technologies, the world of multiphoton processes remains a fascinating puzzle, holding the potential to drastically alter our understanding of how light interacts with matter at its most basic level [1–4]. This rich interplay of light and matter unveils novel phenomena that can be harnessed for sensing with exceptional precision, as exemplified by multiphoton quantum sensing. This thesis delves into the applications of multiphoton quantum protocols, particularly in imaging, communication, and plasmonic sensing, to surpass classical limitations and achieve enhanced sensitivity. We explore the potential of multiphoton quantum processes, …

Temporal Dynamics Of The Multi-Omic Response To Endurance Exercise Training, David Amar, Nicole R. Gay, Pierre M. Jean-Beltran, Dam Bae, Surendra Dasari, Courtney Dennis, Charles R. Evans, David A. Gaul, Olga Ilkayeva, Anna A. Ivanova, Maureen T. Kachman, Hasmik Keshishian, Ian R. Lanza, Ana C. Lira, Michael J. Muehlbauer, Venugopalan D. Nair, Paul D. Piehowski, Jessica L. Rooney, Kevin S. Smith, Cynthia L. Stowe, Bingqing Zhao, Natalie M. Clark, David Jimenez-Morales, Malene E. Lindholm, Gina M. Many, James A. Sanford, Gregory R. Smith, Nikolai G. Vetr, Tiantian Zhang, Jose J. Almagro Armenteros, Julian Avila-Pacheco, Nasim Bararpour, Yongchao Ge, Zhenxin Hou

Clinical Research Faculty Publications

Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood1–3. Here, the Molecular Transducers of Physical Activity Consortium4 profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological …