Digital Commons Network^™

Determining The Impact Of Lethal Temperature And Relative Humidity When Combined With Various Insecticide Classes Against A Bed Bug (Cimex Lectularius) Population., Bandana Shrestha

LSU Master's Theses

Common bed bugs (Cimex lectularius) are obligatory blood-feeding pests that have adapted well to survive in challenging environmental conditions. Known for their high tolerance to dehydration, low water loss, and high critical thermal maximum, they have become difficult to manage. Environmental factors, particularly temperature and humidity, play a significant role in their survival. However, with growing resistance to insecticides, integrated pest management (IPM) strategies are now essential for effective bed bug control. A key strategy in IPM involves combining insecticides with heat treatments. This method aims to overcome the limitations of heat treatment alone, as bed bugs may …

Resource Harvesting For Parallel Functions In Serverless Workflows, Peiman Fotouhi

LSU Master's Theses

In the rapidly evolving landscape of cloud computing, serverless architectures have gained attention for their scalability and cost-effectiveness. This thesis aims to introduce a novel approach to maximize resource utilization in serverless environments through the concept of harvesting idle resources within Directed Acyclic Graph (DAG)-based workloads. Our proposed solution targets resource harvesting at parallel stages by utilizing Machine Learning models to accurately harvest or accelerate serverless functions. Additionally, we present a scheduling algorithm specifically designed to address the unique requirements of DAG workloads in cloud environments.

The framework leverages dynamic resource allocation techniques to identify and exploit idle resources within …

Coloring Trivalent Graphs: A Defect Tft Approach, Amit Kumar

LSU Doctoral Dissertations

We show that the combinatorial matter of graph coloring is, in fact, quantum in the sense of satisfying the sum over all the possible intermediate state properties of a path integral. In our case, the topological field theory (TFT) with defects gives meaning to it. This TFT has the property that when evaluated on a planar trivalent graph, it provides the number of Tait-Coloring of it. Defects can be considered as a generalization of groups. With the Klein-four group as a 1-defect condition, we reinterpret graph coloring as sections of a certain bundle, distinguishing a coloring (global-sections) from a coloring …

The Role Of Siamese In G2 Checkpoint Regulation In Arabidopsis Thaliana, Martha A. Schwall

LSU Doctoral Dissertations

Cyclin-cyclin dependent kinase (Cyclin-CDK) pairs regulate progression through the checkpoints of the cell cycle. They bind with some specificity and must be bound to for their regulative properties to be active. The presence of cyclin-CDKs is conserved throughout eukaryotes, while differences in specifics exist between yeast, animals, and plants. In Arabidopsis, SIAMESE (SIM) is a CDK inhibitor that restricts progression through mitosis. Overexpression of SIM is required for endoreplication in Arabidopsis trichomes, and overexpression of SIM results in increased endoreplication in leaf epidermal cells. SIM is expressed at high levels in the root elongation zone, where it plays a …

The Identity Of A Gymnast: How Health, Wellbeing, And Injury Become Embodied In The Identity Of Collegiate Gymnasts, Skyler M. Yakes

LSU Master's Theses

Gymnastics scholarship has traditionally focused on the physicality of the sport and what the body can and cannot do. This research expands upon gymnastics scholarship by exploring the individual experiences and histories of college gymnasts in the United States through a series of interviews. The goals of this research are to better understand the gymnastics experience and to explore health and wellbeing in gymnastics as it pertains to the formation of a gymnast’s identity. A combined approach using medical anthropology and anthropology of sport serves as a guiding framework for analyzing interview data. Definitions of health and wellbeing change between …

Enhancing Writing By Increasing Metacognitive Skills Through Socratic Seminars In A High Poverty Middle School Social Studies Classroom: An Intrinsic Case Study, Kirsten Hickingbottom

LSU Doctoral Dissertations

The purpose of this intrinsic case study was to better understand the role metacognitive skills play within classroom settings to increase students’ writing through Socratic Seminars. A predominant question guided this study: Can improving student metacognition through the repetitive use of questioning techniques in Socratic Seminars lead to improved writing skills? This question, along with four additional research questions guided the research. There is a need for more activities that promote metacognition due to its correlation with academic achievement, critical thinking skills, problem-solving abilities, and perceived self-efficacy (Keus, 2020). The significance of this study was to examine a method of …

Multiscale & Multiphysics Model Of Damage In Lithium-Ion Batteries, Edris Akbari

LSU Doctoral Dissertations

The demand for safer and more reliable lithium-ion batteries (LIBs) in electric vehicles has increased significantly, especially in addressing mechanical failures like internal short circuits (ISCs), which can lead to thermal runaway. This research investigates the mechanical behavior and damage mechanisms in lithium-ion pouch cells through a multiscale and multiphysics approach, focusing on Lithium Nickel Manganese Cobalt Oxide (NMC) and Lithium Iron Phosphate (LFP) batteries.

The study involved quasi-static and dynamic mechanical tests, including indentation and high-speed penetration, to evaluate stress-strain responses and fracture behaviors. Anisotropic mechanical properties were measured for individual battery components (anode, cathode, separator, and shell) using …

Martial Spirits And Marital Rites: Assessing Rousseau's Critique Of Commerce's Devaluation Of The Military And The Family, Jacob A. Harvey

LSU Doctoral Dissertations

This dissertation will investigate Rousseau’s critique of how commercial society devalues soldiers and families and the responses provided by defenders of commerce. I will examine Rousseau’s corpus to demonstrate how Rousseau viewed commerce as a threat to both the responsibilities that men in a political community must be willing to fight and die for their country, as commercial societies intensify the hedonistic risk-averse calculations within members of the community. I will also show how Rousseau’s concerns towards commerce extended to the family, inhibiting the joys that can come with being part of a family and inhibiting citizens' willingness to have …

Coastal Wetlands In The Anthropocene, John Day, Edward Anthony, Robert Costanza, Douglas Edmonds, Joel Gunn, Charles Hopkinson, Michael E. Mann, James Morris, Michael Osland, Tracy Quirk, Andre Rovai, John Rybczyk, Thomas Spencer, Jessica Stephens, Jaia Syvitski, Robert Twilley, Jenneke Visser, John R. White

Faculty Publications

We review the functioning and sustainability of coastal marshes and mangroves. Urbanized humans have a 7,000-year-old enduring relationship to coastal wetlands. Wetlands include marshes, salt flats, and saline and freshwater forests. Coastal wetlands occur in all climate zones but are most abundant in deltas. Mangroves are tropical, whereas marshes occur from tropical to boreal areas. Quantification of coastal wetland areas has advanced in recent years but is still insufficiently accurate. Climate change and sea-level rise are predicted to lead to significant wetland losses and other impacts on coastal wetlands and the humans associated with them. Landward migration and coastal retreat …

Identification Of An Ionic Mechanism For Erα-Mediated Rapid Excitation In Neurons, Meng Yu, Na Yin, Bing Feng, Peiyu Gao, Kaifan Yu, Hesong Liu, Hailan Liu, Yongxiang Li, Olivia Z. Ginnard, Kristine M. Conde, Mengjie Wang, Xing Fang, Longlong Tu, Jonathan C. Bean, Qingzhuo Liu, Yue Deng, Yuxue Yang, Junying Han, Sanika V. Jossy, Megan L. Burt, Huey Zhong Wong, Yongjie Yang, Benjamin R. Arenkiel, Yang He, Shaodong Guo, Pierre Gourdy, Jean Francois Arnal, Francoise Lenfant, Zhao Wang, Chunmei Wang, Yanlin He, Yong Xu

Division of Basic Science Faculty Publications

The major female ovarian hormone, 17β-estradiol (E2), can alter neuronal excitability within milliseconds to regulate a variety of physiological processes. Estrogen receptor-α (ERα), classically known as a nuclear receptor, exists as a membrane-bound receptor to mediate this rapid action of E2, but the ionic mechanisms remain unclear. Here, we show that a membrane channel protein, chloride intracellular channel protein-1 (Clic1), can physically interact with ERα with a preference to the membrane-bound ERα. Clic1-mediated currents can be enhanced by E2 and reduced by its depletion. In addition, Clic1 currents are required to mediate the E2-induced rapid excitations in multiple brain ERα …

Precision Interventions Targeting The Maternal Metabolic Milieu For Healthy Pregnancies In Obesity, Alexandra M. Niclou, Hannah E. Cabre, Emily W. Flanagan, Leanne M. Redman

Clinical Research Faculty Publications

Purpose of Review: Entering pregnancy with obesity increases the risk of adverse health outcomes for parent and child. As such, research interventions are largely focused on limiting excess gestational weight gain during pregnancy, especially in those with obesity. Yet, while many lifestyle interventions are successful in reducing GWG, few affect pregnancy outcomes. Here we review work targeting the metabolic milieu instead of focusing solely on weight. Recent Findings: Work done in non-pregnant populations suggests that specifically targeting glucose, triglyceride, and leptin levels or inflammatory makers improves the metabolic milieu and overall health. We posit that precision interventions that include strategies …

Exercise In The Management Of Polycystic Ovary Syndrome: A Position Statement From Exercise And Sports Science Australia, Angelo Sabag, Rhiannon K. Patten, Alba Moreno-Asso, Giorgia E. Colombo, Xela Dafauce Bouzo, Lisa J. Moran, Cheryce Harrison, Maryam Kazemi, Aya Mousa, Chau Tien Tay, Angelica Lindén Hirschberg, Leanne M. Redman, Helena J. Teede

Clinical Research Faculty Publications

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition amongst females of reproductive age, leading to lifelong cardiometabolic, reproductive, psychological, and dermatologic symptoms as well as a reduced quality of life. Lifestyle interventions, which can include structured exercise programmes delivered by appropriately trained exercise professionals such as clinical exercise physiologists, are considered first-line strategies in PCOS management due to their therapeutic effects on various health outcomes and quality of life. This position statement builds on the 2023 International Evidence-based Guideline for the Assessment and Management of PCOS and describes the role of the exercise professional in the context of …

Brain Insulin Signaling Is Associated With Late-Life Cognitive Decline, Han Tong, Ana W. Capuano, Owen T. Carmichael, Kathryn L. Gwizdala, David A. Bennett, Rexford S. Ahima, Steven E. Arnold, Zoe Arvanitakis

Clinical Research Faculty Publications

Type-2 diabetes is associated with an increased risk of dementia, and the underlying mechanism might involve abnormal insulin signaling in the brain. The objective of this study was to examine the association of postmortem brain insulin signaling with late-life cognitive decline. Among participants of Religious Orders Study, a community-based clinical-pathological cohort, 150 deceased and autopsied older individuals (75 with diabetes matched to 75 without by age at death, sex, and education) had postmortem brain insulin signaling measurements collected in the prefrontal cortex using ELISA and immunohistochemistry. By using adjusted linear mixed-effects models, we examined the association of postmortem brain insulin …

Prescribed Fire Regimes Influence Responses Of Fungal And Bacterial Communities On New Litter Substrates In A Brackish Tidal Marsh, Viet Q. Dao, Crystal N. Johnson, William J. Platt

Faculty Publications

Processes modifying newly deposited litter substrates should affect fine fuels in fire-managed tidal marsh ecosystems. Differences in chemical composition and dynamics of litter should arise from fire histories that generate pyrodiverse plant communities, tropical cyclones that deposit wrack as litter, tidal inundation that introduces and alters sediments and microbes, and interactions among these different processes. The resulting diversity and dynamics of available litter compounds should affect microbial (fungal and bacterial) communities and their roles in litter substrate dynamics and ecosystem responses over time. We experimentally examined effects of differences in litter types produced by different fire regimes and litter loads …

Regulation Of Bacterial Virulence Genes By Pecs Family Transcription Factors, George C. Nwokocha, Arpita Ghosh, Anne Grove

Faculty Publications

Bacterial plant pathogens adjust their gene expression programs in response to environmental signals and host-derived compounds. This ensures that virulence genes or genes encoding proteins, which promote bacterial fitness in a host environment, are expressed only when needed. Such regulation is in the purview of transcription factors, many of which belong to the ubiquitous multiple antibiotic resistance regulator (MarR) protein family. PecS proteins constitute a subset of this large protein family. PecS has likely been distributed by horizontal gene transfer, along with the divergently encoded efflux pump PecM, suggesting its integration into existing gene regulatory networks. Here, we discuss the …

Louisiana Agriculture Magazine, Fall 2024

Louisiana Agriculture

Questions drive the science behind the LSU AgCenter. Researcher Erin Oberhaus wanted to find data to help educate Louisiana horse owners about the use of an important medication, and a water quality specialist wondered if noneconomic bodies of water, which include agricultural ponds, might help people generate electricity. The research projects that grew from their questions are detailed in this issue of Louisiana Agriculture.

Also in this issue, scientists share the results from important soybean studies, and the AgCenter farm to school team shares success stories from school gardens across the state.

Research is at the core of the LSU …

Fall 2024 Catalog, Lsu Press

LSU Press Seasonal Catalogs

No abstract provided.

Machine Learning For Automated Classification Of Lung Collagen In A Urethane-Induced Lung Injury Mouse Model, Khalid Hamad Alnafisah, Amit Ranjan, Sushant P. Sahu, Jianhua Chen, Sarah Mohammad Alhejji, Alexandra Noël, Manas Ranjan Gartia, Supratik Mukhopadhyay

Faculty Publications

Dysregulation of lung tissue collagen level plays a vital role in understanding how lung diseases progress. However, traditional scoring methods rely on manual histopathological examination introducing subjectivity and inconsistency into the assessment process. These methods are further hampered by inter-observer variability, lack of quantification, and their time-consuming nature. To mitigate these drawbacks, we propose a machine learning-driven framework for automated scoring of lung collagen content. Our study begins with the collection of a lung slide image dataset from adult female mice using second harmonic generation (SHG) microscopy. In our proposed approach, first, we manually extracted features based on the 46 …

Prevailing Issues And Actions In Urban Best Practices Across Latin America And The Caribbean, Fabio Capra-Ribeiro

Faculty Publications

This research examines urban best practices (BPs) across Latin America and the Caribbean to illuminate the prevalent issues and actions associated with these locally implemented initiatives. An analysis of 45 BPs from the UN-Habitat repository was conducted using both quantitative and qualitative methods, organized into three phases. The first phase focused on collecting data such as BP sources, countries of origin, and years of implementation. The second phase identified common problems and actions within the BPs. The third phase involved a cross-sectional analysis to identify significant patterns and trends. The study found that many BPs originated from the Dubai International …

Far From Their Origins: A Transcriptomic Investigation On How 2,4-Di-Tert-Butyl-6-(5-Chloro-2h-Benzotriazol-2-Yl) Phenol Affects Rainbow Trout Alevins, Andreas N.M. Eriksson, Justin Dubiel, Alper James Alcaraz, Jon A. Doering, Steve Wiseman

Faculty Publications

Benzotriazole ultraviolet stabilizers (BUVSs) are a group of widely used chemicals added to a variety of consumer (e.g., plastics) and industrial (e.g., metal coating) goods. Although detected globally as an environmentally persistent pollutant, BUVSs have received relatively little toxicological attention and only recently have been acknowledged to affect development and the endocrine system in vivo. In our previous study, altered behavior, indicative of potential neurotoxicity, was observed among rainbow trout alevins (day 14 posthatching) that were microinjected as embryos with a single environmentally relevant dose of 2,4-di-tert-butyl–6-(5-chloro-2H-benzotriazol-2-yl) phenol (UV-327). In the present follow-up study, we performed whole-transcriptome profiling (RNA sequencing) …

Discarded Vehicle Tires And Their Association With Mosquito Vector Abundance Across Socioenvironmental Gradients In New Orleans, La, Rebeca De Jesús Crespo, Alexandros Pavlakis, Jennifer Breaux, Claudia Riegel

Faculty Publications

Discarded vehicle tires serve as habitat for mosquito vectors. In New Orleans, Louisiana, discarded tires are an increasingly important public concern, especially considering that the city is home to many medically important mosquito species. Discarded tires are known to be associated with mosquito abundance, but how their presence interacts with other socioenvironmental gradients to influence mosquito ecology is poorly understood. Here, we ask whether discarded tire distribution could be explained by social factors, particularly median income, home vacancy and human population density, and whether these factors interact with urban heat islands (UHI) to drive mosquito vector assemblages. We surveyed tire …

On The Injectivity Of The Shifted Funk–Radon Transform And Related Harmonic Analysis, Boris Rubin

Faculty Publications

Necessary and sufficient conditions are obtained for injectivity of the shifted Funk–Radon transform associated with k-dimensional totally geodesic submanifolds of the unit sphere Sⁿ in ℝⁿ⁺¹. This result generalizes the well known statement for the spherical means on Sⁿ and is formulated in terms of zeros of Jacobi polynomials. The relevant harmonic analysis is developed, including a new concept of induced Stiefel (or Grassmannian) harmonics, the Funk–Hecke type theorems, addition formula, and multipliers. Some perspectives and conjectures are discussed.

Toward A Comparative Framework For Studies Of Altitudinal Migration, David Vander Pluym, Nicholas A. Mason

Faculty Publications

The study and importance of altitudinal migration has attracted increasing interest among zoologists. Altitudinal migrants are taxonomically widespread and move across altitudinal gradients as partial or complete migrants, subjecting them to a wide array of environments and ecological interactions. Here, we present a brief synthesis of recent developments in the field and suggest future directions toward a more taxonomically inclusive comparative framework for the study of altitudinal migration. Our framework centers on a working definition of altitudinal migration that hinges on its biological relevance, which is scale-dependent and related to fitness outcomes. We discuss linguistic nuances of altitudinal movements and …

Analysis Of Traffic Operation And Safety At Cloverleaf And Diamond Interchanges With And Without Connected And Autonomous Vehicles, Nischal Khadka

LSU Master's Theses

Even though diamond and cloverleaf interchanges are commonly used in road networks, comparative studies on their operational safety and efficiency remain limited. Also, previous studies have explored the impact of Connected and Autonomous Vehicles (CAVs) at diamond interchanges, but the effects on cloverleaf interchanges are not yet thoroughly investigated. This study addresses these gaps by evaluating the traffic operation and safety performance of cloverleaf interchanges compared to diamond interchanges. It also assesses the influence of various Market Penetration Rates (MPRs) of CAVs on travel time, queue lengths, and conflict points at cloverleaf interchanges, considering different weaving lengths.

Data on peak-hour …

International Consensus On Fasting Terminology, Daniela A. Koppold, Carolin Breinlinger, Etienne Hanslian, Christian Kessler, Holger Cramer, Anika Rajput Khokhar, Courtney M. Peterson, Grant Tinsley, Claudio Vernieri, Richard J. Bloomer, Michael Boschmann, Nicola L. Bragazzi, Sebastian Brandhorst, Kelsey Gabel, Alan C. Goldhamer, Martin M. Grajower, Michelle Harvie, Leonie Heilbronn, Benjamin D. Horne, Spyridon N. Karras, Jost Langhorst, Eva Lischka, Frank Madeo, Sarah J. Mitchell, Ioannis Eleemon Papagiannopoulos-Vatopaidinos, Maria Papagiannopoulou, Hanno Pijl, Eric Ravussin, Martha Ritzmann-Widderich, Krista Varady, Lilian Adamidou, Melika Chihaoui, Rafael De Cabo, Mohamed Hassanein

Clinical Research Faculty Publications

Although fasting is increasingly applied for disease prevention and treatment, consensus on terminology is lacking. Using Delphi methodology, an international, multidisciplinary panel of researchers and clinicians standardized definitions of various fasting approaches in humans. Five online surveys and a live online conference were conducted with 38 experts, 25 of whom completed all 5 surveys. Consensus was achieved for the following terms: “fasting” (voluntary abstinence from some or all foods or foods and beverages), “modified fasting” (restriction of energy intake to max. 25% of energy needs), “fluid-only fasting,” “alternate-day fasting,” “short-term fasting” (lasting 2–3 days), “prolonged fasting” (≥4 consecutive days), and …

Why Are There So Many Definitions Of Eutrophication?, Alexandrine Pannard, Philippe Souchu, Christian Chauvin, Monique Delabuis, Chantal Gascuel-Odoux, Erik Jeppesen, Morgane Le Moal, Alain Ménesguen, Gilles Pinay, Nancy N. Rabalais, Yves Souchon, Elisabeth M. Gross

Faculty Publications

Because of the first observations in the 1900s of the oligotrophic and eutrophic states of lakes, researchers have been interested in the process that makes lakes become turbid because of high phytoplankton biomass. Definitions of eutrophication have multiplied and diversified since the mid-20th century, more than for any other ecological process. Reasons for the high number of definitions might be that the former ones did not sufficiently describe their causes and/or consequences. Global change is bringing eutrophication more into the spotlight than ever, highlighting the need to find consensus on a common definition, or at least to explain and clarify …

Key Uncertainties And Modeling Needs For Managing Living Marine Resources In The Future Arctic Ocean, Julia G. Mason, Andrea Bryndum-Buchholz, Juliano Palacios-Abrantes, Renuka Badhe, Isabella Morgante, Daniele Bianchi, Julia L. Blanchard, Jason D. Everett, Cheryl S. Harrison, Ryan F. Heneghan, Camilla Novaglio, Colleen M. Petrik

Faculty Publications

Emerging fishing activity due to melting ice and poleward species distribution shifts in the rapidly-warming Arctic Ocean challenges transboundary management and requires proactive governance. A 2021 moratorium on commercial fishing in the Arctic high seas provides a 16-year runway for improved scientific understanding. Given substantial knowledge gaps, characterizing areas of highest uncertainty is a key first step. Marine ecosystem model ensembles that project future fish distributions could inform management of future Arctic fisheries, but Arctic-specific variation has not yet been examined for global ensembles. We use the Fisheries and Marine Ecosystem Intercomparison Project ensemble driven by two Earth System Models …

State Of The Science On Brain Insulin Resistance And Cognitive Decline Due To Alzheimer's Disease, Elizabeth M. Rhea, Manon Leclerc, Hussein N. Yassine, Ana W. Capuano, Han Tong, Vladislav A. Petyuk, Shannon L. Macauley, Xavier Fioramonti, Owen Carmichael, Frederic Calon, Zoe Arvanitakis

Clinical Research Faculty Publications

Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with devastating public health consequences. While peripheral insulin resistance is a key feature of most forms of T2DM and has been investigated for over a century, research on brain insulin resistance (BIR) has more recently been developed, including in the context of T2DM and non-diabetes states. Recent data support the presence of BIR in the aging brain, even in non-diabetes states, and found that BIR may be a feature in Alzheimer's disease (AD) and contributes to cognitive impairment. Further, therapies used to treat T2DM are now being investigated …

The Bioenergetic Landscape Of Cancer, Elizabeth R.M. Zunica, Christopher L. Axelrod, L. Anne Gilmore, Erich Gnaiger, John P. Kirwan

Division of Basic Science Faculty Publications

Background: Bioenergetic remodeling of core energy metabolism is essential to the initiation, survival, and progression of cancer cells through exergonic supply of adenosine triphosphate (ATP) and metabolic intermediates, as well as control of redox homeostasis. Mitochondria are evolutionarily conserved organelles that mediate cell survival by conferring energetic plasticity and adaptive potential. Mitochondrial ATP synthesis is coupled to the oxidation of a variety of substrates generated through diverse metabolic pathways. As such, inhibition of the mitochondrial bioenergetic system by restricting metabolite availability, direct inhibition of the respiratory Complexes, altering organelle structure, or coupling efficiency may restrict carcinogenic potential and cancer progression. …

Effects Of Exercise Or Metformin On Myokine Concentrations In Patients With Breast And Colorectal Cancer: A Phase Ii Multi-Centre Factorial Randomized Trial, Justin C. Brown, Guillaume Spielmann, Shengping Yang, Stephanie L.E. Compton, Lee W. Jones, Melinda L. Irwin, Jennifer A. Ligibel, Jeffrey A. Meyerhardt

Faculty Publications

Background: Physical activity and metformin pharmacotherapy are associated with improved clinical outcomes in breast and colorectal cancer survivors. Myokines are cytokines secreted from skeletal muscle that may mediate these associations. Methods: This hypothesis-generating analysis used biospecimens collected from a multi-centre 2 × 2 factorial randomized design of 116 patients with stage I–III breast and colorectal cancer who were randomized to 12 weeks of (1) aerobic exercise (moderate intensity titrated to 220 min/week); (2) metformin (850 mg daily for 2 weeks and then titrated to 850 mg twice per day); (3) aerobic exercise and metformin; or (4) control. Fourteen myokines were …