Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Louisiana State University

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 8521 - 8550 of 13619

Full-Text Articles in Entire DC Network

Characterization Of A Non-Cytoplasmically Localized Dps Protein From Deinococcus Radiodurans, Brian Reon Apr 2008

Characterization Of A Non-Cytoplasmically Localized Dps Protein From Deinococcus Radiodurans, Brian Reon

Honors Capstones

No abstract provided.

Go to article

A Deletion Mutant Of Vitronectin Lacking The Somatomedin B Domain Exhibits Residual Plasminogen Activator Inhibitor-1-Binding Activity, Christine R. Schar, Grant E. Blouse, Kenneth H. Minor, Cynthia B. Peterson Apr 2008

A Deletion Mutant Of Vitronectin Lacking The Somatomedin B Domain Exhibits Residual Plasminogen Activator Inhibitor-1-Binding Activity, Christine R. Schar, Grant E. Blouse, Kenneth H. Minor, Cynthia B. Peterson

Faculty Publications

Vitronectin and plasminogen activator inhibitor-1 (PAI-1) are important physiological binding partners that work in concert to regulate cellular adhesion, migration, and fibrinolysis. The high affinity binding site for PAI-1 is located within the N-terminal somatomedin B domain of vitronectin; however, several studies have suggested a second PAI-1-binding site within vitronectin. To investigate this secondary site, a vitronectin mutant lacking the somatomedin B domain (rΔsBVN) was engineered. The short deletion had no effect on heparin-binding, integrin-binding, or cellular adhesion. Binding to the urokinase receptor was completely abolished while PAI-1 binding was still observed, albeit with a lower affinity. Analytical ultra-centrifugation on …

Go to article

Prevalence Of Temperature-Dependent Heat Capacity Changes In Protein-Dna Interactions, Chin Chi Liu, Allison J. Richard, Kausiki Datta, Vince J. Licata Apr 2008

Prevalence Of Temperature-Dependent Heat Capacity Changes In Protein-Dna Interactions, Chin Chi Liu, Allison J. Richard, Kausiki Datta, Vince J. Licata

Faculty Publications

A large, negative ΔCp of DNA binding is a thermodynamic property of the majority of sequence-specific DNA-protein interactions, and a common, but not universal property of non-sequence-specific DNA binding. In a recent study of the binding of Taq polymerase to DNA, we showed that both the full-length polymerase and its "Klentaq" large fragment bind to primed-template DNA with significant negative heat capacities. Herein, we have extended this analysis by analyzing this data for temperature-variable heat capacity effects (ΔΔCp), and have similarly analyzed an additional 47 protein-DNA binding pairs from the scientific literature. Over half of the systems examined can be …

Go to article

Gold Nanoparticle Sensor For Homocysteine Thiolactone-Induced Protein Modification, Arther T. Gates, Sayo O. Fakayode, Mark Lowry, Gabriela M. Ganea, Abitha Murugeshu, James W. Robinson, Robert M. Strongin, Isiah M. Warner Apr 2008

Gold Nanoparticle Sensor For Homocysteine Thiolactone-Induced Protein Modification, Arther T. Gates, Sayo O. Fakayode, Mark Lowry, Gabriela M. Ganea, Abitha Murugeshu, James W. Robinson, Robert M. Strongin, Isiah M. Warner

Faculty Publications

Homocysteine thiolactone-induced protein modification (HTPM) is a unique post-translational protein modification that is recognized as an emergent biomarker for cardiovascular disease. HTPM involves the site-specific acylation of proteins at lysine residues by homocysteine thiolactone (HTL) to produce protein homocystamide, which has been found at elevated levels in patients with coronary heart disease. Herein, we report the development of a novel gold nanoparticle (GNP) biochemical sensor for detection of protein homocystamide in an in vitro serum protein-based model system. Human serum albumin (HSA) and human sera were subjected to HTPM in vitro to produce HSA-homocystamide or serum protein homocystamide, respectively, which …

Go to article

Airborne Laser Scanning Quantification Of Disturbances From Hurricanes And Lightning Strikes To Mangrove Forests In Everglades National Park, Usa, Keqi Zhang, Marc Simard, Michael Ross, Victor H. Rivera-Monroy, Patricia Houle, Pablo Ruiz, Robert R. Twilley, Kevin R.T. Whelan Apr 2008

Airborne Laser Scanning Quantification Of Disturbances From Hurricanes And Lightning Strikes To Mangrove Forests In Everglades National Park, Usa, Keqi Zhang, Marc Simard, Michael Ross, Victor H. Rivera-Monroy, Patricia Houle, Pablo Ruiz, Robert R. Twilley, Kevin R.T. Whelan

Faculty Publications

Airborne light detection and ranging (LIDAR) measurements derived before and after Hurricanes Katrina and Wilma (2005) were used to quantify the impact of hurricanes and lightning strikes on the mangrove forest at two sites in Everglades National Park (ENP). Analysis of LIDAR measurements covering 61 and 68 ha areas of mangrove forest at the Shark River and Broad River sites showed that the proportion of high tree canopy detected by the LIDAR after the 2005 hurricane season decreased significantly due to defoliation and breakage of branches and trunks, while the proportion of low canopy and the ground increased drastically. Tall …

Go to article

Effects Of Imperfect Dynamic Clamp: Computational And Experimental Results., Bettencourt Jc, Lillis Kp, Stupin Lr, White Ja Apr 2008

Effects Of Imperfect Dynamic Clamp: Computational And Experimental Results., Bettencourt Jc, Lillis Kp, Stupin Lr, White Ja

Faculty Publications

No abstract provided.

Go to article

Further Characterization Of Vibrio Vulnificus Rugose Variants And Identification Of A Capsular And Rugose Exopolysaccharide Gene Cluster, Brenda L. Grau, Margaret C. Henk, Katherine L. Garrison, Brett J. Olivier, Randall M. Schulz, Kathy L. O'Reilly, Gregg S. Pettis Apr 2008

Further Characterization Of Vibrio Vulnificus Rugose Variants And Identification Of A Capsular And Rugose Exopolysaccharide Gene Cluster, Brenda L. Grau, Margaret C. Henk, Katherine L. Garrison, Brett J. Olivier, Randall M. Schulz, Kathy L. O'Reilly, Gregg S. Pettis

Faculty Publications

Capsular polysaccharide (CPS) is a major virulence factor in Vibrio vulnificus, and encapsulated strains have an opaque, smooth (OpS) colony morphology, while nonencapsulated strains have a translucent, smooth (TrS) colony morphology. Previously, we showed that OpS and TrS parental strains can yield a third colony type, rugose (R), and that the resulting strains, with the OpR and TrR phenotypes, respectively, form copious biofilms. Here we show that while OpR and TrR strains both produce three-dimensional biofilm structures that are indicative of rugose extracellular polysaccharide (rEPS) production, OpR strains also retain expression of CPS and are virulent in an iron-supplemented mouse …

Go to article

The Sinorhizobium Meliloti Msba2 Protein Is Essential For The Legume Symbiosis, Sebastian Beck, Victoria L. Marlow, Katy Woodall, William T. Doerrler, Euan K. James, Gail P. Ferguson Apr 2008

The Sinorhizobium Meliloti Msba2 Protein Is Essential For The Legume Symbiosis, Sebastian Beck, Victoria L. Marlow, Katy Woodall, William T. Doerrler, Euan K. James, Gail P. Ferguson

Faculty Publications

Sinorhizobium meliloti is a beneficial legume symbiont, closely related to Brucella species, which are chronic mammalian pathogens. We discovered that the S. meliloti MsbA2 protein is essential to ensure the symbiotic interaction with the host plant, alfalfa. S. meliloti invades plant cells via plant-derived structures known as infection threads. However, in the absence of MsbA2, S. meliloti remains trapped within abnormally thickened infection threads and induces a heightened plant defence response, characterized by a substantial thickening of the nodule endodermis layer and the accumulation of polyphenolic compounds. The S. meliloti MsbA2 protein is homologous to the Escherichia coli lipopolysaccharide/phospholipid trafficking …

Go to article

Photothermal Deflection Determination Of Iron(Ii) With Ferrozine With Sorption Preconcentration On Silufol Plates, A. D. Khrycheva, D. A. Nedosekin, M. A. Proskurnin, M. Y. Kononets, S. V. Pakhomova, W. Faubel Apr 2008

Photothermal Deflection Determination Of Iron(Ii) With Ferrozine With Sorption Preconcentration On Silufol Plates, A. D. Khrycheva, D. A. Nedosekin, M. A. Proskurnin, M. Y. Kononets, S. V. Pakhomova, W. Faubel

Faculty Publications

Photothermal deflection spectroscopy was applied to the selective detection of iron(II) chelate with ferrozine by its sorption preconcentration on Silufol plates. The linearity range was 1 × 10-11-6 × 10 -8 mol cm-2 of chelate at the plate surface, which corresponded to 1 × 10-9 × 10-6 M of chelate in solution. The limits of detection and quantification are 8 × 10 -12 and 2.5 × 10-11 mol cm-2 at the plate from 15 μL of test solution (0.5 nM and 1.5 nM in solution, respectively), and the absolute detection limit is 8 fmol in the whole spot applied to …

Go to article

The Effects Of Epidermal Growth Factor And Basic Fibroblast Growth Factor On Cryopreserved Human Adipose Derived Stem Cells In Culture: Proliferation, Adipogenesis, And Osteogenesis, Teddi Leigh Hebert Apr 2008

The Effects Of Epidermal Growth Factor And Basic Fibroblast Growth Factor On Cryopreserved Human Adipose Derived Stem Cells In Culture: Proliferation, Adipogenesis, And Osteogenesis, Teddi Leigh Hebert

Honors Capstones

No abstract provided.

Go to article

Responses Of The Sea Catfish, Ariopsis Felis, To Chemical Defenses From The Sea Hare, Aplysia Californica, Sheybani Arman Apr 2008

Responses Of The Sea Catfish, Ariopsis Felis, To Chemical Defenses From The Sea Hare, Aplysia Californica, Sheybani Arman

Honors Capstones

No abstract provided.

Go to article

Toxic Gene Expression In Escherichia Coli Using Trpl As A Repressor, Ian Primm Apr 2008

Toxic Gene Expression In Escherichia Coli Using Trpl As A Repressor, Ian Primm

Honors Capstones

No abstract provided.

Go to article

Polyphasic Taxonomy Of A Group Of Globally Dispersed, Desiccation-Resistant Strains Of The Microvirga/Balneimonas Cluster, Bradley Tolar Apr 2008

Polyphasic Taxonomy Of A Group Of Globally Dispersed, Desiccation-Resistant Strains Of The Microvirga/Balneimonas Cluster, Bradley Tolar

Honors Capstones

No abstract provided.

Go to article

Modeling Electric Fields In Microfluidic Devices, Micah Fincher Apr 2008

Modeling Electric Fields In Microfluidic Devices, Micah Fincher

Honors Capstones

No abstract provided.

Go to article

Excess 210Pb Inventories And Fluxes Along The Continental Slope And Basins Of The Gulf Of Papua, Zahid Muhammad, Samuel J. Bentley, Lawrence A. Febo, André W. Droxler, Gerald R. Dickens, Larry C. Peterson, Bradley N. Opdyke Mar 2008

Excess 210Pb Inventories And Fluxes Along The Continental Slope And Basins Of The Gulf Of Papua, Zahid Muhammad, Samuel J. Bentley, Lawrence A. Febo, André W. Droxler, Gerald R. Dickens, Larry C. Peterson, Bradley N. Opdyke

Faculty Publications

Sediment samples were collected from continental slopes and marginal basins in the Gulf of Papua and analyzed for excess 210Pb to elucidate transport processes of fine-grained particles to this region. Estimated excess 210Pb fluxes of 1.0-12.8 dpm cm-2 a-1 were derived from measured seabed inventories. Highest sediment accumulation rates (0.28-0.35 cm a-) were measured along the northeastern shelf edge, and they decrease in seaward directions and along isobaths to the southwest. The excess 210Pb flux could result from either focused deposition of high-210Pb activity sediments from the continental shelf and upper slope or scavenging of 210Pb brought landward from deep-sea …

Go to article

Late Pleistocene And Holocene Sedimentation, Organic-Carbon Delivery, And Paleoclimatic Inferences On The Continental Slope Of The Northern Pandora Trough, Gulf Of Papua, Lawrence A. Febo, Samuel J. Bentley, John H. Wrenn, André W. Droxler, Gerald R. Dickens, Larry C. Peterson, Bradley N. Opdyke Mar 2008

Late Pleistocene And Holocene Sedimentation, Organic-Carbon Delivery, And Paleoclimatic Inferences On The Continental Slope Of The Northern Pandora Trough, Gulf Of Papua, Lawrence A. Febo, Samuel J. Bentley, John H. Wrenn, André W. Droxler, Gerald R. Dickens, Larry C. Peterson, Bradley N. Opdyke

Faculty Publications

We investigated sediment and organic-carbon accumulation rates in two jumbo piston cores (MV-54, MV-51) retrieved from the midslope of the northeastern Pandora Trough in the Gulf of Papua, Papua New Guinea. Our data provide a first assessment of mass fluxes over the past ∼33,000 14C years B.P. and variations in organic-carbon sources. Core sediments were analyzed using a suite of physical properties, organic geochemistry, and micropaleontological measurements. MV-54 and MV-51 show two periods of rapid sediment accumulation. The first interval is from ∼15,000 to 20,400 Cal. years B.P. (MV-51: ∼1.09 in ka-1 and ∼81.2 g cm-2 ka-1) and the second …

Go to article

Monte Carlo Calculations And Measurements Of Absorbed Dose Per Monitor Unit For The Treatment Of Uveal Melanoma With Proton Therapy, Nicholas Koch, Wayne D. Newhauser, Uwe Titt, Dan Gombos, Kevin Coombes, George Starkschall Mar 2008

Monte Carlo Calculations And Measurements Of Absorbed Dose Per Monitor Unit For The Treatment Of Uveal Melanoma With Proton Therapy, Nicholas Koch, Wayne D. Newhauser, Uwe Titt, Dan Gombos, Kevin Coombes, George Starkschall

Faculty Publications

The treatment of uveal melanoma with proton radiotherapy has provided excellent clinical outcomes. However, contemporary treatment planning systems use simplistic dose algorithms that limit the accuracy of relative dose distributions. Further, absolute predictions of absorbed dose per monitor unit are not yet available in these systems. The purpose of this study was to determine if Monte Carlo methods could predict dose per monitor unit (D/MU) value at the center of a proton spread-out Bragg peak (SOBP) to within 1% on measured values for a variety of treatment fields relevant to ocular proton therapy. The MCNPX Monte Carlo transport code, in …

Go to article

Synthesis And In Vitro Properties Of Trimethylamine- And Phosphonate-Substituted Carboranylporphyrins For Application In Bnct, Michael W. Easson, Frank R. Fronczek, Timothy J. Jensen, M. Graça H. Vicente Mar 2008

Synthesis And In Vitro Properties Of Trimethylamine- And Phosphonate-Substituted Carboranylporphyrins For Application In Bnct, Michael W. Easson, Frank R. Fronczek, Timothy J. Jensen, M. Graça H. Vicente

Faculty Publications

A series of carboranylporphyrins containing either amine or phosphonic acid functionalities and two to six closo-carborane clusters have been synthesized via a [2 + 2] condensation of a dimethylamino- or diethylphosphonate-substituted dipyrromethane with a dicarboranylmethyl-benzaldehyde. The X-ray structures of four key reaction intermediates (1, 2, 3, and 4a) and of two target porphyrins, the diphosphonate ester- and the diamino-tetracarboranylporphyrins 5b and 6a, are presented and discussed. In vitro studies using human carcinoma HEp2 and human glioblastoma T98G cells show that these porphyrins are non-toxic in the dark up to 100 μM concentrations, and that a tetracarboranylporphyrin bearing two quaternary ammonium …

Go to article

Molecular Dynamics Simulations Of Biotin Carboxylase, Sten O.Nilsson Lili, Jiali Gao, Grover L. Waldrop Mar 2008

Molecular Dynamics Simulations Of Biotin Carboxylase, Sten O.Nilsson Lili, Jiali Gao, Grover L. Waldrop

Faculty Publications

Biotin carboxylase catalyzes the ATP-dependent carboxylation of biotin and is one component of the multienzyme complex acetyl-CoA carboxylase that catalyzes the first committed step in fatty acid synthesis in all organisms. Biotin carboxylase from Escherichia coli, whose crystal structures with and without ATP bound have been determined, has served as a model system for this component of the acetyl-CoA carboxylase complex. The two crystal structures revealed a large conformational change of one domain relative to the other domains when ATP is bound. Unfortunately, the crystal structure with ATP bound was obtained with an inactive site-directed mutant of the enzyme. As …

Go to article

The Innate Immune Database (Iidb), Martin Korb, G. R. Aistair, Vesteinn Thorsson, Christophe Battail, Bin Li, Daehee Hwang, Kathleen A. Kennedy, Jared C. Roach, Carrie M. Rosenberger, Mark Gilchrist, Daniel Zak, Carrie Johnson, Bruz Marzolf, Alan Aderem, Ilya Shmulevich, Hamid Bolouri Mar 2008

The Innate Immune Database (Iidb), Martin Korb, G. R. Aistair, Vesteinn Thorsson, Christophe Battail, Bin Li, Daehee Hwang, Kathleen A. Kennedy, Jared C. Roach, Carrie M. Rosenberger, Mark Gilchrist, Daniel Zak, Carrie Johnson, Bruz Marzolf, Alan Aderem, Ilya Shmulevich, Hamid Bolouri

Faculty Publications

Background: As part of a National Institute of Allergy and Infectious Diseases funded collaborative project, we have performed over 150 microarray experiments measuring the response of C57/BL6 mouse bone marrow macrophages to toll-like receptor stimuli. These microarray expression profiles are available freely from our project web site http://www.innateImmunity-systemsbiology.org. Here, we report the development of a database of computationally predicted transcription factor binding sites and related genomic features for a set of over 2000 murine immune genes of interest. Our database, which includes microarray co-expression clusters and a host of web-based query, analysis and visualization facilities, is available freely via the …

Go to article

Gratiana Boliviana (Coleoptera: Chrysomelidae) Does Not Feed On Jamaican Nightshade Solanum Jamaicense (Solanaceae), W. A. Overholt, R. Diaz, L. Markle, J. Medal Mar 2008

Gratiana Boliviana (Coleoptera: Chrysomelidae) Does Not Feed On Jamaican Nightshade Solanum Jamaicense (Solanaceae), W. A. Overholt, R. Diaz, L. Markle, J. Medal

Faculty Publications

Jamaican nightshade has been in Florida for at least 77 years, but is considered rare and only found in 4 counties in the central peninsula. However, there are many examples of long lag periods between the time an exotic plant arrives at a new location, and the time it spreads and becomes highly invasive (Sakai et al. 2001). Locally dense populations of Jamaican nightshade in hammock areas in Saint Lucie and Osceola counties suggest that the plant is adapted to at least some habitats in Florida, and could eventually spread to similar habitats and become a serious exotic invader. The …

Go to article

Determination Of Enantiomeric Compositions Of Analytes Using Novel Fluorescent Chiral Molecular Micelles And Steady State Fluorescence Measurements, Alicia A. Williams, Sayo O. Fakayode, Onur Alptürk, Christina M. Jones, Mark Lowry, Robert M. Strongin, Isiah M. Warner Mar 2008

Determination Of Enantiomeric Compositions Of Analytes Using Novel Fluorescent Chiral Molecular Micelles And Steady State Fluorescence Measurements, Alicia A. Williams, Sayo O. Fakayode, Onur Alptürk, Christina M. Jones, Mark Lowry, Robert M. Strongin, Isiah M. Warner

Faculty Publications

Novel fluorescent chiral molecular micelles (FCMMs) were synthesized, characterized, and employed as chiral selectors for enantiomeric recognition of non-fluorescent chiral molecules using steady state fluorescence spectroscopy. The sensitivity of the fluorescence technique allowed for investigation of low concentrations of chiral selector (3.0∈×∈10 -5 M) and analyte (5.0∈×∈10 -6 M) to be used in these studies. The chiral interactions of glucose, tartaric acid, and serine in the presence of FCMMs poly(sodium N-undecanoyl-l-tryptophanate) [poly-l-SUW], poly(sodium N-undecanoyl-l-tyrosinate) [poly-l-SUY], and poly(sodium N-undecanoyl-l- phenylalininate) [poly-SUF] were based on diastereomeric complex formation. Poly-l-SUW had a significant fluorescence emission spectral difference as compared to poly-l-SUY and poly-l-SUF …

Go to article

Afm-Based Lithography For Nanoscale Protein Assays, Johnpeter Ngunjiri, Jayne C. Garno Mar 2008

Afm-Based Lithography For Nanoscale Protein Assays, Johnpeter Ngunjiri, Jayne C. Garno

Faculty Publications

No abstract provided.

Go to article

Achieving Precision And Reproducibility For Writing Patterns Of N-Alkanethiol Self-Assembled Monolayers With Automated Nanografting, Johnpeter N. Ngunjiri, Algernon T. Kelley, Zorabel M. Lejeune, Jie Ren Li, Brian R. Lewandowski, Wilson K. Serem, Stephanie L. Daniels, Kathie L. Lusker, Jayne C. Garno Mar 2008

Achieving Precision And Reproducibility For Writing Patterns Of N-Alkanethiol Self-Assembled Monolayers With Automated Nanografting, Johnpeter N. Ngunjiri, Algernon T. Kelley, Zorabel M. Lejeune, Jie Ren Li, Brian R. Lewandowski, Wilson K. Serem, Stephanie L. Daniels, Kathie L. Lusker, Jayne C. Garno

Faculty Publications

Nanografting is a high-precision approach for scanning probe lithography, which provides unique advantages and capabilities for rapidly writing arrays of nanopatterns of thiol self-assembled monolayers (SAMs). Nanografting is accomplished by force-induced displacement of molecules of a matrix SAM, followed immediately by the self-assembly of n-alkanethiol ink molecules from solution. The feedback loop used to control the atomic force microscope tip position and displacement enables exquisite control of forces applied to the surface, ranging from pico to nanonewtons. To achieve high-resolution writing at the nanoscale, the writing speed, direction, and applied force need to be optimized. There are strategies for programing …

Go to article

Collpas: Activity Hotspots For Frugivorous Bats (Phyllostomidae) In The Peruvian Amazon, Adriana Bravo, Kyle E. Harms, Richard D. Stevens, Louise H. Emmons Mar 2008

Collpas: Activity Hotspots For Frugivorous Bats (Phyllostomidae) In The Peruvian Amazon, Adriana Bravo, Kyle E. Harms, Richard D. Stevens, Louise H. Emmons

Faculty Publications

In the SE Peruvian Amazon, large numbers of frugivorous bats regularly visit natural forest clearings known locally as collpas (which are also referred to as clay licks or mineral licks). Bats arrive at collpas to drink water that has accumulated in depressions created by larger geophagous mammals that consume exposed soil. Although collpa visitation is common, little is known about its causes and its ecological implications for the bat community. We compared patterns of use of collpas and non-collpa forest sites by bats in SE Peru. We mist netted bats at collpas and non-collpa sites during the dry season and …

Go to article

Laboratory And Field Evaluations Of Silwet L-77 And Kinetic Alone And In Combination With Imidacloprid And Abamectin For The Management Of The Asian Citrus Psyllid, Diaphorina Citri (Hemiptera: Psyllidae), Rajagopalbabu Srinivasan, Marjorie A. Hoy, Raghuwinder Singh, Michael E. Rogers Mar 2008

Laboratory And Field Evaluations Of Silwet L-77 And Kinetic Alone And In Combination With Imidacloprid And Abamectin For The Management Of The Asian Citrus Psyllid, Diaphorina Citri (Hemiptera: Psyllidae), Rajagopalbabu Srinivasan, Marjorie A. Hoy, Raghuwinder Singh, Michael E. Rogers

Faculty Publications

Silwet L-77, an organosilicone adjuvant, was used to enhance coverage of an entomopathogenic fungus in field trials conducted in a central Florida citrus research grove. The results indicated that Silwet L-77, by itself, was toxic to nymphs of the Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Psyllidae). Laboratory bioassays were conducted to confirm the toxicity of the adjuvant to eggs, nymphs, and adults of D. citri. Silwet L-77 at 0.05% (500 ppm) killed all nymphs, but was not as effective against eggs and adults. However, Silwet L-77, when combined with a reduced rate (one-tenth the lowest label rate = LLR) …

Go to article

The Human Intermediate Filament Database: Comprehensive Information On A Gene Family Involved In Many Human Diseases, Ildiko Szeverenyi, Andrew J. Cassidy, Wang Chung Cheuk, Bernett T.K. Lee, John E.A. Common, Stephen C. Ogg, Huijia Chen, Yin Sim Shu, Walter L.P. Goh, Woei Ng Kee, John A. Simpson, Lian Chee Li, Hui Eng Goi, Bin Li, Declan P. Lunny, Danny Chuon, Aparna Venkatesh, Hoe Khoo Kian, W. H.Irwin Mclean, Ping Lim Yun, E. Birgitte Lane Mar 2008

The Human Intermediate Filament Database: Comprehensive Information On A Gene Family Involved In Many Human Diseases, Ildiko Szeverenyi, Andrew J. Cassidy, Wang Chung Cheuk, Bernett T.K. Lee, John E.A. Common, Stephen C. Ogg, Huijia Chen, Yin Sim Shu, Walter L.P. Goh, Woei Ng Kee, John A. Simpson, Lian Chee Li, Hui Eng Goi, Bin Li, Declan P. Lunny, Danny Chuon, Aparna Venkatesh, Hoe Khoo Kian, W. H.Irwin Mclean, Ping Lim Yun, E. Birgitte Lane

Faculty Publications

We describe a revised and expanded database on human intermediate filament proteins, a major component of the eukaryotic cytoskeleton. The family of 70 intermediate filament genes (including those encoding keratins, desmins, and lamins) is now known to be associated with a wide range of diverse diseases, at least 72 distinct human pathologies, including skin blistering, muscular dystrophy, cardiomyopathy, premature aging syndromes, neurodegenerative disorders, and cataract. To date, the database catalogs 1,274 manually-curated pathogenic sequence variants and 170 allelic variants in intermediate filament genes from over 459 peer-reviewed research articles. Unrelated cases were collected from all of the six sequence homology …

Go to article

Systems Biology Approaches Identify Atf3 As A Negative Regulator Of Toll-Like Receptor 4 (Nature (2006) 441, (173-178)), Mark Gilchrist, Vesteinn Thorsson, Bin Li, Alistair G. Rust, Martin Korb, Jared C. Roach, Kathleen Kennedy, Tsonwin Hai, Hamid Bolouri, Alan Aderem Feb 2008

Systems Biology Approaches Identify Atf3 As A Negative Regulator Of Toll-Like Receptor 4 (Nature (2006) 441, (173-178)), Mark Gilchrist, Vesteinn Thorsson, Bin Li, Alistair G. Rust, Martin Korb, Jared C. Roach, Kathleen Kennedy, Tsonwin Hai, Hamid Bolouri, Alan Aderem

Faculty Publications

No abstract provided.

Go to article

Two Chloride Sources In Soils Of The Mcmurdo Dry Valleys, Antarctica, Huiming Bao, Jaime D. Barnes, Zachary D. Sharp, David R. Marchant Feb 2008

Two Chloride Sources In Soils Of The Mcmurdo Dry Valleys, Antarctica, Huiming Bao, Jaime D. Barnes, Zachary D. Sharp, David R. Marchant

Faculty Publications

Sulfate, nitrate, and chloride are major water-soluble anions in soils of the McMurdo Dry Valleys (MDV), Antarctica. We measured the chloride stable isotope composition of 40 soil samples from 16 different soil profiles. The soil profiles come from three different microclimate zones in the MDV: a coastal thaw zone, which fosters a seasonally saturated active layer; a stable upland zone, in which air and soil temperatures are too cold to foster active layers and/or significant snowmelt; and an intermediate, inland mixed zone. Results show that the total water-soluble chloride content is low in both the coastal and the upland zones, …

Go to article

Two Chloride Sources In Soils Of The Mcmurdo Dry Valleys, Antarctica, Huiming Bao, Jaime D. Barnes, Zachary D. Sharp, David R. Marchant Feb 2008

Two Chloride Sources In Soils Of The Mcmurdo Dry Valleys, Antarctica, Huiming Bao, Jaime D. Barnes, Zachary D. Sharp, David R. Marchant

Faculty Publications

Sulfate, nitrate, and chloride are major water-soluble anions in soils of the McMurdo Dry Valleys (MDV), Antarctica. We measured the chloride stable isotope composition of 40 soil samples from 16 different soil profiles. The soil profiles come from three different microclimate zones in the MDV: a coastal thaw zone, which fosters a seasonally saturated active layer; a stable upland zone, in which air and soil temperatures are too cold to foster active layers and/or significant snowmelt; and an intermediate, inland mixed zone. Results show that the total water-soluble chloride content is low in both the coastal and the upland zones, …

Go to article

First Prev Next Last