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Functional Characterization Of A Zinc Finger Protein Aebp2, Hana Kim Jan 2010

Functional Characterization Of A Zinc Finger Protein Aebp2, Hana Kim

LSU Doctoral Dissertations

AEBP2 is a zinc finger protein that has been shown to interact with the mammalian Polycomb Repression Complex 2 (PRC2). I characterized this unknown protein and tested its potential targeting roles for the PRC2. AEBP2 is an evolutionarily well-conserved gene that is found in animals ranging from flying insects to mammals. The transcription of mammalian AEBP2 is driven by two alternative promoters and produces multiple transcripts that give rise to at least two isoforms of the protein. These isoforms show developmental stage-specific expression patterns: the larger adult-specific form (52 kDa) and the smaller embryo-specific form (31 kDa). The AEBP2 protein …

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Testing Models Of Biological Diversification: Morphological Evolution And Cladogenesis In The Neotropical Furnariidae (Aves: Passeriformes), Santiago Javier Claramunt Tammaro Jan 2010

Testing Models Of Biological Diversification: Morphological Evolution And Cladogenesis In The Neotropical Furnariidae (Aves: Passeriformes), Santiago Javier Claramunt Tammaro

LSU Doctoral Dissertations

In this dissertation I explored the processes that generated high species diversity in a continental adaptive radiation of passerine birds: the family Furnariidae. Although there is a vast amount of information on the microevolutionary mechanisms that generate speciation and adaptation, much less is known about the processes underlying large-scale patterns of diversity. I used new techniques that exploit information contained in phylogenetic trees to investigate the diversification process in Furnariidae at a macroevolutionary scale. First, I conducted the first quantitative study that demonstrated that the Furnariidae constitute a case of rapid diversification in both species numbers and morphology as compared …

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Embyronic Nicotine Exposure And Its Impact On Spinal Neuron Development In Zebrafish, Latoya Telameca Paul Jan 2010

Embyronic Nicotine Exposure And Its Impact On Spinal Neuron Development In Zebrafish, Latoya Telameca Paul

LSU Doctoral Dissertations

Nicotine, a drug of abuse, has been shown to have deleterious outcomes on nervous system development in vertebrates. Using zebrafish behavior as a diagnostic tool, we aimed to understand the effects of embryonic nicotine exposure on spinal neuron development. We initially quantified nicotine incorporation into zebrafish embryos. We found that only a fraction of the waterborne concentration of nicotine was incorporated into embryos. Also, when embryos were exposed to epibatidine and ABT 418, potent alpha 4/beta 2 nAChRs agonists, the embryos exhibited a robust swim-like behavioral response similar to that of nicotine. We then performed immunohistochemistry utilizing the mAB290 antibody …

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Water And Solute Transport In The Shallow Subsurface Of A Riverine Wetland Natural Levee, April Elea Newman Jan 2010

Water And Solute Transport In The Shallow Subsurface Of A Riverine Wetland Natural Levee, April Elea Newman

LSU Master's Theses

In riverine wetlands, the rate and magnitude of water exchanged between river channels and adjacent wetlands have a major influence on hydrologic function and associated aquatic habitat and water quality. River channels are generally separated from backswamps by natural levees; however, preferential flow may allow potentially substantial water and solute exchange between them. Determining the influence of preferential flow on water and solute transport in natural levees requires an innovative approach that allows measurement of transport rates at a scale large enough to capture field-scale variability. To test the hypothesis that preferential flow is important to subsurface water movement through …

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Physical And Microbial Responses Of Dredged Sediment To Two-Soil-Stabilizing Amendments, Xanthan Gum And Guar Gum, For Use In Coastal Wetland Restoration, Lauren Land Jan 2010

Physical And Microbial Responses Of Dredged Sediment To Two-Soil-Stabilizing Amendments, Xanthan Gum And Guar Gum, For Use In Coastal Wetland Restoration, Lauren Land

LSU Master's Theses

In wetland sediments, organic matter provides a substrate for microbial activity. During metabolism, microbes release extracellular polymeric substances, which accumulate to bind soil particles. A similar concept can be implemented on a large scale to reduce wetland loss in Louisiana. Hypothetically, hydraulically dredged sediment can be amended with polymer and deposited on subsiding marshes as a restoration method where the polymer increases sediment stabilization until plants become established. This lab study focused on investigating the influence of natural polymer additions on particle aggregation to increase sediment stability and the effects on microbial activity. Sediments from three sites (i.e. freshwater, intermediate, …

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Caged Morpholino Oligonucleotide For Control Of Gene Expression In Zebrafish, Chad Michael Jarreau Jan 2010

Caged Morpholino Oligonucleotide For Control Of Gene Expression In Zebrafish, Chad Michael Jarreau

LSU Master's Theses

To control gene expression in vivo with spatial and temporal precision remains a significant hurdle in laboratory studies of development as well as clinical genetic therapies. Here we demonstrate such control over gene expression by use of photochemistry to reversibly inactivate the hybridization of a nucleic acid analog used for specific protein knockdown. A morpholino oligonucleotide, commonly used for knockdown of protein expression in developmental studies, was “caged” using carbodiimide conjugate chemistry which yielded photocleavable adducts that can be removed with light exposure. Photochemical inactivation approaches to produce caged molecules have been used to control the spatiotemporal activity of biomolecules …

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Impact Of Urban Runoff On Phosphorus, Nitrogen, And Dissolved Oxygen In A Shallow Subtropical Lake, Ryan Mesmer Jan 2010

Impact Of Urban Runoff On Phosphorus, Nitrogen, And Dissolved Oxygen In A Shallow Subtropical Lake, Ryan Mesmer

LSU Master's Theses

This research assessed the current conditions of water quality in a shallow subtropical lake, influenced by a highly developed urban environment. Specifically, the research focused on the dynamics of phosphorus, nitrogen, and dissolved oxygen, as well as the effects of stormwater runoff on lake water quality. Furthermore, the research quantified gross primary production, net primary production, and respiration in order to discern seasonal variation in lake metabolism. A water quality monitoring platform with multi-parameter probes was deployed in the center of University Lake on the Louisiana State University campus. A series of lake water quality parameters including dissolved oxygen (DO) …

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Microfluidic Devices Interfaced To Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry For Proteomics, Jeonghoon Lee Jan 2010

Microfluidic Devices Interfaced To Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry For Proteomics, Jeonghoon Lee

LSU Doctoral Dissertations

Microfluidic interfaces were developed for off-line matrix-assisted laser desorption/ionization mass spectrometry (MALDI). Microfluidic interfaces allow samples to be manipulated on-chip and deposited onto a MALDI target plate for analysis. For this research, microfluidic culturing devices and automated digestion and deposition microfluidic chip platforms were developed for the identification of proteins. The microfluidic chip components were fabricated on a poly(methyl methacrylate), PMMA, wafer using the hot embossing method and a molding tool with structures prepared via micromilling. One of the most important components of the chip system was a trypsin microreactor. An open channel microreactor was constructed in a 100 µm …

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Predator-Prey Interaction In Estuarine Bivalves: Size Selection, Effects Of Salinity, And Indirect Interactions, Barry Richard Aronhime Jan 2010

Predator-Prey Interaction In Estuarine Bivalves: Size Selection, Effects Of Salinity, And Indirect Interactions, Barry Richard Aronhime

LSU Doctoral Dissertations

High stress environments can reduce species diversity. How such stress-induced reduction in predator diversity impacts prey survival is less well studied. Brackish waters in estuaries are stressful, species depauperate areas, but also prime oyster habitat in Louisiana. Surveys revealed reduced bivalve predator diversity at the low salinity (high stress) site. Exclosure experiments indicated highest prey mortality at the high salinity (low stress) site. Predator enclosures corroborated the field study results, with reduced consumption rates at the low salinity site for both stone crabs, Menippe adina and oyster drills Stramonita haemastoma, but not blue crabs, Callinectes sapidus. Blue crab mortality in …

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Spatial Analyses Of Pedosphere Carbon Stock And Sequestration Potential In Louisiana's Watersheds, Biao Zhong Jan 2010

Spatial Analyses Of Pedosphere Carbon Stock And Sequestration Potential In Louisiana's Watersheds, Biao Zhong

LSU Doctoral Dissertations

This dissertation research aimed to quantify current soil organic carbon (SOC) stocks across Louisiana’s landscape, examine the spatial relationships between SOC and terrain factors at the watershed and river basin scales, and predict SOC changes in surface soils during future climate change. Using Louisiana as an example, a spatially-explicit modeling framework was developed that is conducive to watershed-scale prediction of soil carbon stock and change. SOC densities at the watershed scale were estimated using the USDA NRCS Soil Geographic Database (STATSGO). Louisiana watersheds and National Land Cover Database (NLCD) were used to aggregate total soil carbon and estimate average soil …

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Part I: Syntheses, Characterizations, And Investigations Of Molecular Micelles And Imidazolium-Based Ionic Liquids For Protein Separations In Electrophoresis Part Ii: Investigating The Mentoring Canon Through Exploration Of Thirty Years Of Mentoring By An Exemplar, Monica R. Sylvain Jan 2010

Part I: Syntheses, Characterizations, And Investigations Of Molecular Micelles And Imidazolium-Based Ionic Liquids For Protein Separations In Electrophoresis Part Ii: Investigating The Mentoring Canon Through Exploration Of Thirty Years Of Mentoring By An Exemplar, Monica R. Sylvain

LSU Doctoral Dissertations

The research reported in this dissertation is presented in two parts. The first part is the Syntheses, Characterizations, and Investigations of Molecular Micelles and Imidazolium-Based Ionic Liquids for Protein Separations in Electrophoresis, and the second part is a case study entitled Investigating the Mentoring Canon through Exploration of Thirty Years of Mentoring by an Exemplar. Protein separations in the gel electrophoretic format are ubiquitous analyses used on a daily basis throughout biochemistry, analytical chemistry, and biotechnology. The goal of the research reported in the first part of this dissertation is to synthesize and characterize molecular micelles and ether-functionalized imidazolium-based ionic …

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Data Transfer Scheduling With Advance Reservation And Provisioning, Mehmet Balman Jan 2010

Data Transfer Scheduling With Advance Reservation And Provisioning, Mehmet Balman

LSU Doctoral Dissertations

Over the years, scientific applications have become more complex and more data intensive. Although through the use of distributed resources the institutions and organizations gain access to the resources needed for their large-scale applications, complex middleware is required to orchestrate the use of these storage and network resources between collaborating parties, and to manage the end-to-end processing of data. We present a new data scheduling paradigm with advance reservation and provisioning. Our methodology provides a basis for provisioning end-to-end high performance data transfers which require integration between system, storage and network resources, and coordination between reservation managers and data transfer …

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Bioaerosols And The Risk Of Upper Respiratory Infection In Dental Hygienists, Christen Rebecca Gautreau Jan 2010

Bioaerosols And The Risk Of Upper Respiratory Infection In Dental Hygienists, Christen Rebecca Gautreau

LSU Master's Theses

Multitudes of pathogenic and infectious microbes are known to spread via contaminated aerosols. Dental personnel have an increased incidence of respiratory infections. Ultrasonic scaling procedures are reported to produce the largest amounts of contaminated aerosols of any dental procedure. The goal of the current study was to see if dental hygienists are at an increased risk of respiratory infections during the performance of their job and to see if certain dental procedures had a significant effect on this risk. This study was conducted at the Dental Hygiene Clinic of the Louisiana State University School of Dentistry in New Orleans, LA. …

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Value-Added Processing Of Rice And Rice By-Products, Rebecca C. Schramm Jan 2010

Value-Added Processing Of Rice And Rice By-Products, Rebecca C. Schramm

LSU Doctoral Dissertations

World competition has encouraged United States rice farmers and rice mills to be efficient in farming and production practices. Efforts to augment economic competitiveness include development of new varieties, improvements in milling practices, and identification of uses for rice products and by-products. The research detailed in this dissertation adds to the body of knowledge in milling practices and identification of uses for rice bran. To improve the prediction of milled rice quality at industrial scale, correlations for milling quality among laboratory, pilot, and industrial scale mills were identified for Clearfield 161. Final industrial product whiteness was ten points higher than …

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Recreating The Image Of Women In Mexico: A Genealogy Of Resistance In Mexican Narrative Set During The Revolution, Julia Maria Schneider Jan 2010

Recreating The Image Of Women In Mexico: A Genealogy Of Resistance In Mexican Narrative Set During The Revolution, Julia Maria Schneider

LSU Master's Theses

Traditionally, women have been relegated to the margins of society, history, and culture in male-dominated environments. Patriarchal systems have long denied women to play an appropriate role in nation building and to enter the public sphere, as is the case in Mexico. The female participation during one of the country’s most critical periods, the Mexican Revolution, has largely been ignored. Through situating their narratives into the context of the Revolution and describing the obstacles and limiting conditions that women experience, Mexican writers such as Elena Poniatowska and Laura Esquivel criticize the status quo of social and gender politics in Mexico …

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Identification Of A Tumor-Targeting-Peptide And Development Of A Tumor-Targeted-Cytokine Vector For Systemic Treatment Of Primary And Metastatic Malignancies, Jeffry Cutrera Jan 2010

Identification Of A Tumor-Targeting-Peptide And Development Of A Tumor-Targeted-Cytokine Vector For Systemic Treatment Of Primary And Metastatic Malignancies, Jeffry Cutrera

LSU Doctoral Dissertations

Advances in cancer therapies continue to be improved, yet cancer continues to be one of the deadliest diseases in the world. Harnessing the power of the body’s immune system to attack cancer is a promising strategy that can further improve therapies for neoplastic diseases. As part of this strategy, cytokines such as interleukin (IL) 2 and interferon á are currently accepted cancer treatments, and other cytokines such as IL12 and GM-CSF also show potential as new treatments. Clinical trials with these cytokines have shown less than acceptable therapeutic efficacy and toxicities, but tumor-targeting motifs can improve these effects. Both antibodies …

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Spatial Variations Of Salinity, Temperature And Pressure On The Flank Of A Salt Dome, Offshore Louisiana: Implications For Mechanisms Of Fluid Flow, Andrew Kevin Steen Jan 2010

Spatial Variations Of Salinity, Temperature And Pressure On The Flank Of A Salt Dome, Offshore Louisiana: Implications For Mechanisms Of Fluid Flow, Andrew Kevin Steen

LSU Master's Theses

Salt dome dissolution in the Gulf of Mexico sedimentary basin is a primary cause for elevated pore water salinities in the subsurface. Temperature, pressure, salinity, lithology and fluid density are parameters often used to identify preferential conduits and driving forces for fluid migration. These parameters were calculated using 20 wireline logs covering 40 km² on the south flank of a salt dome on the continental shelf, offshore Louisiana. 3-D seismic has been utilized to determine location of faults, to aid in sand correlation, and to provide a structural overview of the dome. Vertical and lateral variations in lithology, salinity, temperature, …

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Factors Affecting Adoption Of Cover Crops And Its Effect On Nitrogen Use By Producers, Gnel Gabrielyan Jan 2010

Factors Affecting Adoption Of Cover Crops And Its Effect On Nitrogen Use By Producers, Gnel Gabrielyan

LSU Master's Theses

Increasing environmental concerns, population, and changing preferences of consumers towards healthier foods, and agronomic practices have all aligned to provide not only food and fiber, but also sustainable practices useful to the environment. Cover crops, a type of agricultural technology, provide private and public benefits, which are vital for organic production. The objectives of this study are: 1) Identify determinants of cover crop adoption; 2) analyze how nitrogen management varies by farm relative to adoption or non-adoption of this technology; 3) estimate the change in the probability of adoption of cover crops due to farm, regional and operator characteristics by …

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Retention And Transport Of Mercury And Nickel In Soils, Lixia Liao Jan 2010

Retention And Transport Of Mercury And Nickel In Soils, Lixia Liao

LSU Doctoral Dissertations

Nickel (Ni) is one of many trace metals widely distributed in the environment. High concentrations of Ni in soils and aquifers have been observed worldwide, causing several potential human health impacts. Better understanding of Ni transport in soils and aquifers is necessary to assess and remediate insitu environmental contamination. The movement of Ni in soils and aquifers is highly dependent on adsorption-desorption reactions in the solid phase. In this study, kinetic batch, sequential extractions, and miscible displacement experiments were conducted to investigate the effect of several of environmental factors including soil type, reaction time and competing ions, on the fate …

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Signaling Of Integrin Lower Leg And Transmembrane Domains, Wei Wang Jan 2010

Signaling Of Integrin Lower Leg And Transmembrane Domains, Wei Wang

LSU Doctoral Dissertations

Integrin conformational changes mediate integrin activation and signaling triggered by intracellular molecules or extracellular ligands. Even though it has been shown that TM and/or cytoplasmic α and β domains associate in the resting state and separation of these domains is required for integrin signaling, it is still not clear how this signal is transmitted from the transmembrane domain through two long extracellular legs to the ligand-binding headpiece. In addition, integrin TM homomeric association was also observed. But the role of this interaction remains elusive. In this work, the platelet integrin, αIIbβ3, has been used to elucidate the roles of integrin …

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The Relationship Between Social Skills And Challenging Behaviors In Children With Autism Spectrum Disorders, Jonathan Wilkins Jan 2010

The Relationship Between Social Skills And Challenging Behaviors In Children With Autism Spectrum Disorders, Jonathan Wilkins

LSU Doctoral Dissertations

The autism spectrum disorders (ASD) are among the most serious and debilitating conditions with onset in early childhood. Deficits in social interaction skills are considered to be the hallmark set of symptoms and are given the most weight in current diagnostic systems. Although not considered among the core symptoms of ASD, challenging behaviors in the form of physical aggression, property destruction, and self-injury also commonly occur. Challenging behaviors of this nature are a salient feature of ASD because of their potential to cause harm to self and others as well as limit a child’s access to opportunities in community and …

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Ospc In The Pathogenesis Of Borrelia Burgdorferi, Sunita V. Seemanapalli Jan 2010

Ospc In The Pathogenesis Of Borrelia Burgdorferi, Sunita V. Seemanapalli

LSU Doctoral Dissertations

Lyme disease is a multisystem disorder caused by the tick vector Borrelia burgdorferi. During its life cycle between the tick vector and the mammalian host, Borrelia up- and down-regulates the expression of its surface lipoproteins. Of its many surface lipoproteins, the Outer surface protein C (OspC) is crucial for initial mammalian infection. OspC has a common role shared with other lipoproteins of protection against host innate defences and a unique function in facilitating the dissemination of B. burgdorferi in the murine host. The structure of OspC was solved in 2001 and the lipoprotein was found to be predominantly alpha-helical with …

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Studies Of Nanoparticles From A Group Of Uniform Materials Based On Organic Salts (Gumbos), Aaron Tesfai Jan 2010

Studies Of Nanoparticles From A Group Of Uniform Materials Based On Organic Salts (Gumbos), Aaron Tesfai

LSU Doctoral Dissertations

Tesfai, Aaron, B.S., B.A., University of Missouri, Columbia, 2003 Doctor of Philosophy, Spring Commencement 2010 Major: Chemistry Studies of Nanoparticles from a Group of Uniform Materials Based on Organic Salts (GUMBOS) Dissertation directed by Professor Isiah M. Warner Pages in dissertation, 101. Words in abstract, 271. Ionic liquids (ILs) are defined as organic salts composed of ions with melting points at or below 100 °C. ILs have gained considerable attention because of their desirable properties such as low volatility, high thermal stability, and tunability. GUMBOS are an emergent class of organic salts, many of which are ionic liquids (ILs). However, …

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Third-Wave Feminism In Select Young Adult Literature, Colleen Mckinney Jan 2010

Third-Wave Feminism In Select Young Adult Literature, Colleen Mckinney

Honors Capstones

No abstract provided.

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Geological Analysis And Hydrodynamic Modeling Of Tropical Cyclone Influence: Northeastern Gulf Of Mexico Inner Shelf, Amy Lynn Spaziani Jan 2010

Geological Analysis And Hydrodynamic Modeling Of Tropical Cyclone Influence: Northeastern Gulf Of Mexico Inner Shelf, Amy Lynn Spaziani

LSU Master's Theses

The need to characterize offshore resources as borrow areas for beach restoration has initiated interest of the impact of storms to the inner continental shelf. While numerous studies have investigated the response of coastal systems to major storms, very little is known about the geological response of inner shelves to frequent and intense storms. This approach integrated a geological study with modeling of hydrodynamics during recent storms, in order to relate trends in the geological signature to physical forcing mechanisms during storms. First, waves and hydrodynamic conditions were modeled during two major recent storms that made landfall in the northeastern …

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Using Algae To Estimate Postmortem Submersion Interval In A Louisiana Bayou, Sophia Renke Jan 2010

Using Algae To Estimate Postmortem Submersion Interval In A Louisiana Bayou, Sophia Renke

LSU Master's Theses

While algae are often used in forensic science for the determination and confirmation of death by drowning, their utility for the estimation of postmortem submersion interval (PMSI) has been underutilized. Algae are present in all water systems and will grow upon decomposing matter; yet, very little published literature exists on their use in PMSI estimation. Because PMSI is difficult to predict due to the variable nature of water, the reaction of the submerged body within water, and the lack of truly sarcophagous aquatic insects, algae are a potentially invaluable tool for the forensic anthropologist. This research investigates the utility of …

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Spatial And Temporal Variabilities On Soils In St. Landry Parish, Louisiana, Stephanie Lynn Johnson Jan 2010

Spatial And Temporal Variabilities On Soils In St. Landry Parish, Louisiana, Stephanie Lynn Johnson

LSU Master's Theses

The spatial and temporal variation of soil properties was evaluated on three sites in close proximity to Bayou Wikoff, St. Landry Parish, Louisiana. A total of 1,068 surface (0-5 cm) samples were collected, geo-located, and transported to Louisiana State University for physical and chemical analyses. Physical and chemical properties were spatially and temporally displayed using ArcGIS. Interpolation techniques such as spline, kriging, and inverse distance weighting were evaluated to determine the best fit model for the project. Spline and inverse distance weighting were found to be the least accurate interpolation models. Kriging provided the most accurate model of spatial and …

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Relative Height And Weight Among Children And Adolescents Of Rural Southwestern Nigeria, Omolola Ayoola, Kara Ebersole, Olayemi O. Omotade, Bamidele O. Tayo, William R. Brieger, Kabiru Salami, Lara R. Dugas, Richard S. Cooper, Amy Luke Dec 2009

Relative Height And Weight Among Children And Adolescents Of Rural Southwestern Nigeria, Omolola Ayoola, Kara Ebersole, Olayemi O. Omotade, Bamidele O. Tayo, William R. Brieger, Kabiru Salami, Lara R. Dugas, Richard S. Cooper, Amy Luke

Faculty Publications

Background: There are few data describing the relative height and weight patterns of children and adolescents in rural Nigeria, despite a prevalence of stunting of over 38% among children younger than 5 years. Aim: The present study documented the height and weight patterns relative to international standards among children and adolescents aged 520 years in rural Nigeria. Subjects and methods: Children 520 years of age were enrolled from two rural villages. Height and weight were measured; body composition was estimated using bioelectrical impedance analysis. z-scores and centiles for height and body mass index were calculated; prevalences of low relative height …

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Reply To Zimmerman Et Al.: The Space Of Single Domain Protein Structures Is Continuous And Highly Connected, Jeffrey Skolnick, Michal Brylinski, Seung Yup Lee Dec 2009

Reply To Zimmerman Et Al.: The Space Of Single Domain Protein Structures Is Continuous And Highly Connected, Jeffrey Skolnick, Michal Brylinski, Seung Yup Lee

Faculty Publications

No abstract provided.

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Monte Carlo Simulation Of The Neutron Spectral Fluence And Dose Equivalent For Use In Shielding A Proton Therapy Vault, Yuanshui Zheng, Wayne Newhauser, Eric Klein, Daniel Low Dec 2009

Monte Carlo Simulation Of The Neutron Spectral Fluence And Dose Equivalent For Use In Shielding A Proton Therapy Vault, Yuanshui Zheng, Wayne Newhauser, Eric Klein, Daniel Low

Faculty Publications

Neutron production is of principal concern when designing proton therapy vault shielding. Conventionally, neutron calculations are based on analytical methods, which do not accurately consider beam shaping components and nozzle shielding. The goal of this study was to calculate, using Monte Carlo modeling, the neutron spectral fluence and neutron dose equivalent generated by a realistic proton therapy nozzle and evaluate how these data could be used in shielding calculations. We modeled a contemporary passive scattering proton therapy nozzle in detail with the MCNPX simulation code. The neutron spectral fluence and dose equivalent at various locations in the treatment room were …

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