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Lea Proteins During Water Stress: Not Just For Plants Anymore, Steven C. Hand, Michael A. Menze, Mehmet Toner, Leaf Boswell, Daniel Moore Feb 2011

Lea Proteins During Water Stress: Not Just For Plants Anymore, Steven C. Hand, Michael A. Menze, Mehmet Toner, Leaf Boswell, Daniel Moore

Faculty Publications

Late embryogenesis abundant (LEA) proteins are extremely hydrophilic proteins that were first identified in land plants. Intracellular accumulation is tightly correlated with acquisition of desiccation tolerance, and data support their capacity to stabilize other proteins and membranes during drying, especially in the presence of sugars like trehalose. Exciting reports now show that LEA proteins are not restricted to plants; multiple forms are expressed in desiccation-tolerant animals from at least four phyla. We evaluate here the expression, subcellular localization, biochemical properties, and potential functions of LEA proteins in animal species during water stress. LEA proteins are intrinsically unstructured in aqueous solution, …

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A New Emoia Samoensis Group Lizard (Squamata: Scincidae) From The Cook Islands, South-Central Pacific, George R. Zug, Alison M. Hamilton, Christopher C. Austin Feb 2011

A New Emoia Samoensis Group Lizard (Squamata: Scincidae) From The Cook Islands, South-Central Pacific, George R. Zug, Alison M. Hamilton, Christopher C. Austin

Faculty Publications

The first published report of a large treeskink from Rarotonga, Cook Islands, appeared in 1988. The first museum voucher specimen was collected in 1984. Although this skink seems likely to be a recent arrival to the island of Rarotonga, it represents a unique member of the Emoia samoensis species group. We compare this population with other members of the E. samoensis group and describe the population as Emoia tuitarere n. sp., distinguished by a suite of external characters including SVL, number of dorsal scale rows, and number of subdigital lamellae of the fourth toe. We provide preliminary definitions for the …

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Isolation Of A Rickettsial Pathogen From A Non-Hematophagous Arthropod, Chutima Thepparit, Piyanate Sunyakumthorn, Mark L. Guillotte, Vsevolod L. Popov, Lane D. Foil, Kevin R. Macaluso Feb 2011

Isolation Of A Rickettsial Pathogen From A Non-Hematophagous Arthropod, Chutima Thepparit, Piyanate Sunyakumthorn, Mark L. Guillotte, Vsevolod L. Popov, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

Rickettsial diversity is intriguing in that some species are transmissible to vertebrates, while others appear exclusive to invertebrate hosts. Of particular interest is Rickettsia felis, identifiable in both stored product insect pests and hematophagous disease vectors. To understand rickettsial survival tactics in, and probable movement between, both insect systems will explicate the determinants of rickettsial pathogenicity. Towards this objective, a population of Liposcelis bostrychophila, common booklice, was successfully used for rickettsial isolation in ISE6 (tick-derived cells). Rickettsiae were also observed in L. bostrychophila by electron microscopy and in paraffin sections of booklice by immunofluorescence assay using anti-R. felis polyclonal antibody. …

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Mapping Copy Number Variation By Population-Scale Genome Sequencing, Ryan E. Mills, Klaudia Walter, Chip Stewart, Robert E. Handsaker, Ken Chen, Can Alkan, Alexej Abyzov, Seungtai Chris Yoon, Kai Ye, R. Keira Cheetham, Asif Chinwalla, Donald F. Conrad, Yutao Fu, Fabian Grubert, Iman Hajirasouliha, Fereydoun Hormozdiari, Lilia M. Iakoucheva, Zamin Iqbal, Shuli Kang, Jeffrey M. Kidd, Miriam K. Konkel, Joshua Korn, Ekta Khurana, Deniz Kural, Hugo Y.K. Lam, Jing Leng, Ruiqiang Li, Yingrui Li, Chang Yun Lin, Ruibang Luo, Xinmeng Jasmine Mu, James Nemesh, Heather E. Peckham, Tobias Rausch Feb 2011

Mapping Copy Number Variation By Population-Scale Genome Sequencing, Ryan E. Mills, Klaudia Walter, Chip Stewart, Robert E. Handsaker, Ken Chen, Can Alkan, Alexej Abyzov, Seungtai Chris Yoon, Kai Ye, R. Keira Cheetham, Asif Chinwalla, Donald F. Conrad, Yutao Fu, Fabian Grubert, Iman Hajirasouliha, Fereydoun Hormozdiari, Lilia M. Iakoucheva, Zamin Iqbal, Shuli Kang, Jeffrey M. Kidd, Miriam K. Konkel, Joshua Korn, Ekta Khurana, Deniz Kural, Hugo Y.K. Lam, Jing Leng, Ruiqiang Li, Yingrui Li, Chang Yun Lin, Ruibang Luo, Xinmeng Jasmine Mu, James Nemesh, Heather E. Peckham, Tobias Rausch

Faculty Publications

Genomic structural variants (SVs) are abundant in humans, differing from other forms of variation in extent, origin and functional impact. Despite progress in SV characterization, the nucleotide resolution architecture of most SVs remains unknown. We constructed a map of unbalanced SVs (that is, copy number variants) based on whole genome DNA sequencing data from 185 human genomes, integrating evidence from complementary SV discovery approaches with extensive experimental validations. Our map encompassed 22,025 deletions and 6,000 additional SVs, including insertions and tandem duplications. Most SVs (53%) were mapped to nucleotide resolution, which facilitated analysing their origin and functional impact. We examined …

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Metals Affect The Structure And Activity Of Human Plasminogen Activator Inhibitor-1. I. Modulation Of Stability And Protease Inhibition, Lawrence C. Thompson, Sumit Goswami, David S. Ginsberg, Duane E. Day, Ingrid M. Verhamme, Cynthia B. Peterson Feb 2011

Metals Affect The Structure And Activity Of Human Plasminogen Activator Inhibitor-1. I. Modulation Of Stability And Protease Inhibition, Lawrence C. Thompson, Sumit Goswami, David S. Ginsberg, Duane E. Day, Ingrid M. Verhamme, Cynthia B. Peterson

Faculty Publications

Human plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor with a metastable active conformation. Under physiological conditions, half of the inhibitor transitions to a latent state within 1-2 h. The interaction between PAI-1 and the plasma protein vitronectin prolongs this active lifespan by ∼50%. Previously, our group demonstrated that PAI-1 binds to resins using immobilized metal affinity chromatography (Day, U.S. Pat. 7,015,021 B2, March 21, 2006). In this study, the effect of these metals on function and stability was investigated by measuring the rate of the transition from the active to latent conformation. All metals tested showed …

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Metals Affect The Structure And Activity Of Human Plasminogen Activator Inhibitor-1. Ii. Binding Affinity And Conformational Changes, Lawrence C. Thompson, Sumit Goswami, Cynthia B. Peterson Feb 2011

Metals Affect The Structure And Activity Of Human Plasminogen Activator Inhibitor-1. Ii. Binding Affinity And Conformational Changes, Lawrence C. Thompson, Sumit Goswami, Cynthia B. Peterson

Faculty Publications

Human plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor with a metastable active conformation. The lifespan of the active form of PAI-1 is modulated via interaction with the plasma protein, vitronectin, and various metal ions. These metal ions fall into two categories: Type I metals, including calcium, magnesium, and manganese, stabilize PAI-1 in the absence of vitronectin, whereas Type II metals, including cobalt, copper, and nickel, destabilize PAI-1 in the absence of vitronectin, but stabilize PAI-1 in its presence. To provide a mechanistic basis for understanding the unusual modulation of PAI-1 structure and activity, the binding characteristics …

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The Nlrp3 Inflammasome Instigates Obesity-Induced Inflammation And Insulin Resistance, Bolormaa Vandanmagsar, Yun Hee Youm, Anthony Ravussin, Jose E. Galgani, Krisztian Stadler, Randall L. Mynatt, Eric Ravussin, Jacqueline M. Stephens, Vishwa Deep Dixit Feb 2011

The Nlrp3 Inflammasome Instigates Obesity-Induced Inflammation And Insulin Resistance, Bolormaa Vandanmagsar, Yun Hee Youm, Anthony Ravussin, Jose E. Galgani, Krisztian Stadler, Randall L. Mynatt, Eric Ravussin, Jacqueline M. Stephens, Vishwa Deep Dixit

Faculty Publications

The emergence of chronic inflammation during obesity in the absence of overt infection or well-defined autoimmune processes is a puzzling phenomenon. The Nod-like receptor (NLR) family of innate immune cell sensors, such as the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (Nlrp3, but also known as Nalp3 or cryopyrin) inflammasome are implicated in recognizing certain nonmicrobial originated 'danger signals' leading to caspase-1 activation and subsequent interleukin-1β 2 (IL-1β 2) and IL-18 secretion. We show that calorie restriction and exercise-mediated weight loss in obese individuals with type 2 diabetes is associated with a reduction in adipose tissue expression of Nlrp3 as well …

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Neighborhood Stressors And Race/Ethnic Differences In Hypertension Prevalence (The Multi-Ethnic Study Of Atherosclerosis), Mahasin S. Mujahid, Ana V. Diez Roux, Richard C. Cooper, Steven Shea, David R. Williams Feb 2011

Neighborhood Stressors And Race/Ethnic Differences In Hypertension Prevalence (The Multi-Ethnic Study Of Atherosclerosis), Mahasin S. Mujahid, Ana V. Diez Roux, Richard C. Cooper, Steven Shea, David R. Williams

Faculty Publications

BackgroundThe reasons for racial/ethnic disparities in hypertension (HTN) prevalence in the United States are poorly understood.MethodsUsing data from the Multi-Ethnic Study of Atherosclerosis (MESA), we investigated whether individual- and neighborhood-level chronic stressors contribute to these disparities in cross-sectional analyses. The sample consisted of 2,679 MESA participants (45-84 years) residing in Baltimore, New York, and North Carolina. HTN was defined as systolic or diastolic blood pressure 140 or 90mmHg, or taking antihypertensive medications. Individual-level chronic stress was measured by self-reported chronic burden and perceived major and everyday discrimination. A measure of neighborhood (census tract) chronic stressors (i.e., physical disorder, violence) was …

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High-Throughput Cryopreservation Of Spermatozoa Of Blue Catfish (Ictalurus Furcatus): Establishment Of An Approach For Commercial-Scale Processing, E. Hu, Huiping Yang, Terrence R. Tiersch Feb 2011

High-Throughput Cryopreservation Of Spermatozoa Of Blue Catfish (Ictalurus Furcatus): Establishment Of An Approach For Commercial-Scale Processing, E. Hu, Huiping Yang, Terrence R. Tiersch

Faculty Publications

Hybrid catfish created by crossing of female channel catfish (Ictalurus punctatus) and male blue catfish (Ictalurus furcatus) are being used increasingly in foodfish aquaculture because of their fast growth and efficient food conversion. However, the availability of blue catfish males is limited, and their peak spawning is at a different time than that of the channel catfish. As such, cryopreservation of sperm of blue catfish could improve production of hybrid catfish, and has been studied in the laboratory and tested for feasibility in a commercial dairy bull cryopreservation facility. However, an approach for commercially relevant production of cryopreserved blue catfish …

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Comparative And Demographic Analysis Of Orang-Utan Genomes, Devin P. Locke, Ladeana W. Hillier, Wesley C. Warren, Kim C. Worley, Lynne V. Nazareth, Donna M. Muzny, Shiaw Pyng Yang, Zhengyuan Wang, Asif T. Chinwalla, Pat Minx, Makedonka Mitreva, Lisa Cook, Kim D. Delehaunty, Catrina Fronick, Heather Schmidt, Lucinda A. Fulton, Robert S. Fulton, Joanne O. Nelson, Vincent Magrini, Craig Pohl, Tina A. Graves, Chris Markovic, Andy Cree, Huyen H. Dinh, Jennifer Hume, Christie L. Kovar, Gerald R. Fowler, Gerton Lunter, Stephen Meader, Andreas Heger, Chris P. Ponting, Tomas Marques-Bonet, Can Alkan, Lin Chen Jan 2011

Comparative And Demographic Analysis Of Orang-Utan Genomes, Devin P. Locke, Ladeana W. Hillier, Wesley C. Warren, Kim C. Worley, Lynne V. Nazareth, Donna M. Muzny, Shiaw Pyng Yang, Zhengyuan Wang, Asif T. Chinwalla, Pat Minx, Makedonka Mitreva, Lisa Cook, Kim D. Delehaunty, Catrina Fronick, Heather Schmidt, Lucinda A. Fulton, Robert S. Fulton, Joanne O. Nelson, Vincent Magrini, Craig Pohl, Tina A. Graves, Chris Markovic, Andy Cree, Huyen H. Dinh, Jennifer Hume, Christie L. Kovar, Gerald R. Fowler, Gerton Lunter, Stephen Meader, Andreas Heger, Chris P. Ponting, Tomas Marques-Bonet, Can Alkan, Lin Chen

Faculty Publications

Orang-utan- is derived from a Malay term meaning man of the forest- and aptly describes the southeast Asian great apes native to Sumatra and Borneo. The orang-utan species, Pongo abelii (Sumatran) and Pongo pygmaeus (Bornean), are the most phylogenetically distant great apes from humans, thereby providing an informative perspective on hominid evolution. Here we present a Sumatran orang-utan draft genome assembly and short read sequence data from five Sumatran and five Bornean orang-utan genomes. Our analyses reveal that, compared to other primates, the orang-utan genome has many unique features. Structural evolution of the orang-utan genome has proceeded much more slowly …

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Tests Of Integrin Transmembrane Domain Homo-Oligomerization During Integrin Ligand Binding And Signaling, Wei Wang, Jieqing Zhu, Timothy A. Springer, Bing Hao Luo Jan 2011

Tests Of Integrin Transmembrane Domain Homo-Oligomerization During Integrin Ligand Binding And Signaling, Wei Wang, Jieqing Zhu, Timothy A. Springer, Bing Hao Luo

Faculty Publications

Integrin transmembrane (TM) and/or cytoplasmic domains play a critical role in integrin bidirectional signaling. Although it has been shown that TM and/or cytoplasmic α and β domains associate in the resting state and separation of these domains is required for both inside-out and outside-in signaling, the role of TM homomeric association remains elusive. Formation of TM homo-oligomers was observed in micelles and bacterial membranes previously, and it has been proposed that homomeric association is important for integrin activation and clustering. This study addresses whether integrin TM domains form homo-oligomers in mammalian cell membranes using cysteine scanning mutagenesis. Our results show …

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Dma1 Ubiquitinates The Sin Scaffold, Sid4, To Impede The Mitotic Localization Of Plo1 Kinase, Alyssa E. Johnson, Kathleen L. Gould Jan 2011

Dma1 Ubiquitinates The Sin Scaffold, Sid4, To Impede The Mitotic Localization Of Plo1 Kinase, Alyssa E. Johnson, Kathleen L. Gould

Faculty Publications

Proper cell division requires strict coordination between mitotic exit and cytokinesis. In the event of a mitotic error, cytokinesis must be inhibited to ensure equal partitioning of genetic material. In the fission yeast, Schizosaccharomyces pombe, the checkpoint protein and E3 ubiquitin ligase, Dma1, delays cytokinesis by inhibiting the septation initiation network (SIN) when chromosomes are not attached to the mitotic spindle. To elucidate the mechanism by which Dma1 inhibits the SIN, we screened all SIN components as potential Dma1 substrates and found that the SIN scaffold protein, Sid4, is ubiquitinated in vivo in a Dma1-dependent manner. To investigate the role …

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The Structure Of Human 5-Lipoxygenase, Nathaniel C. Gilbert, Sue G. Bartlett, Maria T. Waight, David B. Neau, William E. Boeglin, Alan R. Brash, Marcia E. Newcomer Jan 2011

The Structure Of Human 5-Lipoxygenase, Nathaniel C. Gilbert, Sue G. Bartlett, Maria T. Waight, David B. Neau, William E. Boeglin, Alan R. Brash, Marcia E. Newcomer

Faculty Publications

The synthesis of both proinflammatory leukotrienes and anti-inflammatory lipoxins requires the enzyme 5-lipoxygenase (5-LOX). 5-LOX activity is short-lived, apparently in part because of an intrinsic instability of the enzyme. We identified a 5-LOX-specific destabilizing sequence that is involved in orienting the carboxyl terminus, which binds the catalytic iron. Here, we report the crystal structure at 2.4 angstrom resolution of human 5-LOX stabilized by replacement of this sequence.

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Changing The Culture Of Science Education At Research Universities, W. A. Anderson, U. Banerjee, C. L. Drennan, S. C.R. Elgin, I. R. Epstein, J. Handelsman, G. F. Hatfull, R. Losick, D. K. O'Dowd, B. M. Olivera, S. A. Strobel, G. C. Walker, I. M. Warner Jan 2011

Changing The Culture Of Science Education At Research Universities, W. A. Anderson, U. Banerjee, C. L. Drennan, S. C.R. Elgin, I. R. Epstein, J. Handelsman, G. F. Hatfull, R. Losick, D. K. O'Dowd, B. M. Olivera, S. A. Strobel, G. C. Walker, I. M. Warner

Faculty Publications

No abstract provided.

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Coastal Land Loss And Hypoxia: The 'Outwelling' Hypothesis Revisited, Anindita Das, Dubravko Justic, Erick M. Swenson, R. Euigene Turner, Masamichi Inoue, Dongho Park Jan 2011

Coastal Land Loss And Hypoxia: The 'Outwelling' Hypothesis Revisited, Anindita Das, Dubravko Justic, Erick M. Swenson, R. Euigene Turner, Masamichi Inoue, Dongho Park

Faculty Publications

It is generally believed that interannual variability in the areal extent of the Gulf of Mexico hypoxia is driven primarily by the magnitude of the Mississippi River freshwater and nutrient fluxes. It has recently been proposed that outwelling of carbon from deteriorating coastal wetlands into the surrounding Gulf of Mexico could be an important mechanism promoting the development of hypoxia. We used a coupled hydrology-hydrodynamics model of the Barataria estuary, a site of massive wetland loss, to calculate the fluxes of nitrogen, chlorophyll a and carbon at the estuary-ocean interface. The hydrology model calculates runoff from rainfall and evaporation data, …

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Seasonal Microphytobenthos On The Hypoxic Northern Gulf Of Mexico Continental Shelf, M M. Baustian, N N. Rabalais, W L. Morrison, R. Eugene Turner, M M. Baustian Jan 2011

Seasonal Microphytobenthos On The Hypoxic Northern Gulf Of Mexico Continental Shelf, M M. Baustian, N N. Rabalais, W L. Morrison, R. Eugene Turner, M M. Baustian

Faculty Publications

The presence of photosynthetic organisms on the seafloor may indicate whether oxygen evolution contributes to the bottom water oxygen pool in the hypoxic area of the northern Gulf of Mexico. We sampled 3 stations (depth: 14, 20 and 23 m) 100 km west of the mouth of the Mississippi River over 3 hypoxic annual cycles to determine whether microphytobenthos or settled phytoplankton existed on the sediment surface. Microscopy and high-performance liquid chromatography were used to determine the presence and composition, and to estimate the biomass of microphytobenthos and phytoplankton in surface and bottom waters and sediments. The sediment community (cells …

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Integrating Stomach Content And Stable Isotope Analyses To Quantify The Diets Of Pygoscelid Penguins, Michael J. Polito, Wayne Z. Trivelpiece, Nina J. Karnovsky, Elizabeth Ng, William P. Patterson, Steven D. Emslie Jan 2011

Integrating Stomach Content And Stable Isotope Analyses To Quantify The Diets Of Pygoscelid Penguins, Michael J. Polito, Wayne Z. Trivelpiece, Nina J. Karnovsky, Elizabeth Ng, William P. Patterson, Steven D. Emslie

Faculty Publications

No abstract provided.

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Troubled Waters Of The Gulf Of Mexico, N.N. Rabalais Jan 2011

Troubled Waters Of The Gulf Of Mexico, N.N. Rabalais

Faculty Publications

No abstract provided.

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Gennet: A Platform For Hybrid Network Experiments., Kispersky Tj, Economo Mn, Randeria P, White Ja Jan 2011

Gennet: A Platform For Hybrid Network Experiments., Kispersky Tj, Economo Mn, Randeria P, White Ja

Faculty Publications

No abstract provided.

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Summertime Tidal Flushing Of Barataria Bay: Transports Of Water And Suspended Sediments, Chunyan Li, John R. White, Changsheng Chen, Huichan Lin, Eddie Weeks, Kari Galvan, Sibel Bargu Jan 2011

Summertime Tidal Flushing Of Barataria Bay: Transports Of Water And Suspended Sediments, Chunyan Li, John R. White, Changsheng Chen, Huichan Lin, Eddie Weeks, Kari Galvan, Sibel Bargu

Faculty Publications

Inlets provide a critical ecological link between restricted bays and estuaries to the coastal ocean. The net fluxes of water and suspended sediment are presented in this study. These fluxes are obtained based on data from a multidisciplinary, full tidal cycle survey across Barataria Pass in southern Louisiana on 31 July to 1 August 2008. The velocity profiles were obtained with an acoustic Doppler current profiler mounted on a small boat continuously crossing the inlet, which contains swift and turbulent tidal currents. Water samples were collected six times in a 24 h period at three discrete depths and three locations …

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Plasticity Of The Reproductive Axis Caused By Social Status Change In An African Cichlid Fish: I. Pituitary Gonadotropins, Karen P. Maruska, Berta Levavi-Sivan, Jakob Biran, Russell D. Fernald Jan 2011

Plasticity Of The Reproductive Axis Caused By Social Status Change In An African Cichlid Fish: I. Pituitary Gonadotropins, Karen P. Maruska, Berta Levavi-Sivan, Jakob Biran, Russell D. Fernald

Faculty Publications

Social position in a dominance hierarchy is often tightly coupled with fertility. Consequently,ananimal that can recognize and rapidly take advantage of anopportunity to rise inrankwillhaveareproductive advantage. Reproduction in all vertebrates is controlled by the brain-pituitary-gonad axis,andin males of the African cichlid fish Astatotilapia burtoni, GnRH1 neurons at the apex of this axis are under social control. However, little is known about how quickly social information is transformed into functional reproductive change, or about how socially controlled changes in GnRH1 neurons influence downstream actions of the brain-pituitary-gonad axis. We created an opportunity for reproductively suppressed males to ascend in status and …

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Gebp/Gpl Transcription Factors Regulate A Subset Of Cpr5-Dependent Processes, Daniel Perazza, Frédéric Laporte, Claudine Balagué, Florian Chevalier, Shanterika Remo, Mickaël Bourge, John Larkin, Michel Herzog, Gilles Vachon Jan 2011

Gebp/Gpl Transcription Factors Regulate A Subset Of Cpr5-Dependent Processes, Daniel Perazza, Frédéric Laporte, Claudine Balagué, Florian Chevalier, Shanterika Remo, Mickaël Bourge, John Larkin, Michel Herzog, Gilles Vachon

Faculty Publications

The CONSTITUTIVE EXPRESSOR OF PATHOGENESIS-RELATED GENES5 (CPR5) gene of Arabidopsis (Arabidopsis thaliana) encodes a putative membrane protein of unknown biochemical function and displays highly pleiotropic functions, particularly in pathogen responses, cell proliferation, cell expansion, and cell death. Here, we demonstrate a link between CPR5 and the GLABRA1 ENHANCER BINDING PROTEIN (GeBP) family of transcription factors. We investigated the primary role of the GeBP/GeBP-like (GPL) genes using transcriptomic analysis of the quadruple gebp gpl1,2,3 mutant and one overexpressing line that displays several cpr5-like phenotypes including dwarfism, spontaneous necrotic lesions, and increased pathogen resistance. We found that GeBP/GPLs regulate a set of …

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Syntheses, Properties And Cellular Studies Of Metallo-Isoporphyrins, Sandra C. Mwakwari, Haijun Wang, Timothy J. Jensen, M. Graça H. Vicente, Kevin M. Smith Jan 2011

Syntheses, Properties And Cellular Studies Of Metallo-Isoporphyrins, Sandra C. Mwakwari, Haijun Wang, Timothy J. Jensen, M. Graça H. Vicente, Kevin M. Smith

Faculty Publications

b-Bilene hydrochlorides are shown to be improved intermediates for the synthesis of metallo-isoporphyrins in enhanced yields (28% vs. 6%). Several new diamagnetic zinc(II) and a novel paramagnetic copper(II) isoporphyrin salts were also obtained using this approach. Metal-free isoporphyrins were also isolated. In vitro studies using human carcinoma HEp2 cells show that all metallo-isoporphyrins accumulate within cells and localize partially in the mitochondria. The zinc-isoporphyrins were found to be moderately phototoxic while the copper complex showed the lowest phototoxicity, maybe as a result of its paramagnetic nature. © 2011 World Scientific Publishing Company.

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Faculty Senate Newsletter, January 2011, Louisiana State University And Agricultural & Mechanical College Jan 2011

Faculty Senate Newsletter, January 2011, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Message from the President: Brutus, when consigning Caesar to eternity, seeks attention from friends, Romans, and countrymen, asking them to lend him their ears. Had he been living in Baton Rouge in 2011, he might well have added to that list “coalitions,” the Flagship Coalition being the newest among the many supporters and compatriots seeking citizenship in the Tiger Empire. Brutus, of course, was himself not the most dependable of friends; he called for numerous “ears” knowing well that listening would be a wise strategy in turbulent times. He offered a list of affiliated parties—friends, Romans, and countrymen— suspecting that …

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Elliott Sober: Did Darwin Write The Origin Backwards? Philosophical Essays On Darwin’S Theory, Charles H. Pence, Hope Hollocher, Ryan Nichols, Grant Ramsey, Edwin Siu, Daniel John Sportiello Jan 2011

Elliott Sober: Did Darwin Write The Origin Backwards? Philosophical Essays On Darwin’S Theory, Charles H. Pence, Hope Hollocher, Ryan Nichols, Grant Ramsey, Edwin Siu, Daniel John Sportiello

Faculty Publications

No abstract provided.

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School Of Renewable Natural Resources Newsletter, Fall 2011, Louisiana State University And Agricultural & Mechanical College Jan 2011

School Of Renewable Natural Resources Newsletter, Fall 2011, Louisiana State University And Agricultural & Mechanical College

Research Matters & RNR Newsletters

The annual newsletter from the School of Renewable Natural Resources was a publication which aimed to update and entertain interested readers with the news and research from RNR faculty, students and staff.

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Louisiana Agriculture Winter, 2011, Lsu Agcenter Jan 2011

Louisiana Agriculture Winter, 2011, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

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Application Of A Novel Boronated Porphyrin (H2Ocp) As A Dual Sensitizer For Both Pdt And Bnct, Ryo Hiramatsu, Shinji Kawabata, Shin Ichi Miyatake, Toshihiko Kuroiwa, Michael W. Easson, M. Graça H. Vicente Jan 2011

Application Of A Novel Boronated Porphyrin (H2Ocp) As A Dual Sensitizer For Both Pdt And Bnct, Ryo Hiramatsu, Shinji Kawabata, Shin Ichi Miyatake, Toshihiko Kuroiwa, Michael W. Easson, M. Graça H. Vicente

Faculty Publications

Background: and Objective Boronated porphyrins have emerged as promising dual sensitizers for use in both photodynamic therapy (PDT) and boron neutron capture therapy (BNCT), by virtue of their known tumor affinity, low cytotoxicity in dark conditions, and easy synthesis with high boron content. Octa-anionic 5,10,15,20-tetra[3,5-(nido-carboranylmethyl)phenyl] porphyrin (H2OCP) is a boronated porphyrin having eight boron clusters linked to the porphyrin ring. To evaluate H2OCP's applicability to both PDT and BNCT, we performed an in vitro and ex vivo study using F98 rat glioma cells. Materials and Methods We examined the time-dependent cellular uptake of H 2OCP by measuring the boron concentration …

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Plasticity Of The Reproductive Axis Caused By Social Status Change In An African Cichlid Fish: Ii. Testicular Gene Expression And Spermatogenesis, Karen P. Maruska, Russell D. Fernald Jan 2011

Plasticity Of The Reproductive Axis Caused By Social Status Change In An African Cichlid Fish: Ii. Testicular Gene Expression And Spermatogenesis, Karen P. Maruska, Russell D. Fernald

Faculty Publications

Reproduction in all vertebrates is controlled by the brain-pituitary-gonad (BPG) axis, which is regulated socially in males of the African cichlid fish Astatotilapia burtoni.Althoughsocial information influences GnRH1 neurons at the apex of the BPG axis, little is known about how the social environment and dominance affects the cellular and molecular composition of the testes to regulate reproductive capacity. We created an opportunity for reproductively suppressed males to ascend in status and then measured changes in gene expression and tissue morphology to discover how quickly the perception of this opportunitycaninfluencethetestes.Ourresultsshowrapid up-regulation ofmRNAlevels ofFSH receptorandseveral steroid receptor subtypes inthetestesduringsocial ascent. In contrast,LHreceptor …

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Virus-Derived Sirnas And Pirnas In Immunity And Pathogenesis, Shou Wei Ding, Rui Lu Jan 2011

Virus-Derived Sirnas And Pirnas In Immunity And Pathogenesis, Shou Wei Ding, Rui Lu

Faculty Publications

Cellular organisms have evolved related pathways for the biogenesis and function of small interfering RNAs (siRNAs), microRNAs and PIWI-interacting RNAs (piRNAs). These distinct classes of small RNAs guide specific gene silencing at both transcriptional and posttranscriptional levels by serving as specificity determinants. Small RNAs of virus and host origins have been found to modulate virus-host interactions by RNA interference (RNAi), leading to antiviral immunity or viral pathogenesis. Deep sequencing-based profiling of virus-derived small RNAs as products of host immune recognition not only allowed us to gain insight into the expansion and functional specialization of host factors involved in the antiviral …

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