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Dental Genetic Traits Of Selected Maya Burials From Wild Cane Cay And Moho Cay, Belize, Kelly Heim

Honors Capstones

No abstract provided.

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A Tutorial Of Manual Segmentation Using The Visualization Program Avizo® As Illustrated By The Skeleton Of The Spiny Dogfish Shark, Squalus Acanthias, Mateusz A. Lapucha

Honors Capstones

No abstract provided.

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Modeling A Model Organism: The Lamprey, Petromyzon Marinus, Bradley M. Wood

Honors Capstones

No abstract provided.

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Genomic Mechanisms Of Evolved Physiological Plasticity In Killifish Distributed Along An Environmental Salinity Gradient, Andrew Whitehead, Jennifer L. Roach, Shujun Zhang, Fernando Galvez

Faculty Publications

Adaptive variation tends to emerge clinally along environmental gradients or discretely among habitats with limited connectivity. However, in Atlantic killifish (Fundulus heteroclitus), a population genetic discontinuity appears in the absence of obvious barriers to gene flow along parallel salinity clines and coincides with a physiologically stressful salinity. We show that populations resident on either side of this discontinuity differ in their abilities to compensate for osmotic shock and illustrate the physiological and functional genomic basis of population variation in hypoosmotic tolerance. A population native to a freshwater habitat, upstream of the genetic discontinuity, exhibits tolerance to extreme hypoosmotic challenge, whereas …

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Rex1/Zfp42 As An Epigenetic Regulator For Genomic Imprinting, Jeong Do Kim, Hana Kim, Muhammad B. Ekram, Sungryul Yu, Christopher Faulk, Joomyeong Kim

Faculty Publications

Zfp42/Rex1 (reduced expression gene 1) is a well-known stem-cell marker that has been duplicated from YY1 in the eutherian lineage. In the current study, we characterized the in vivo roles of Rex1 using a mutant mouse line disrupting its transcription. In contrast to the ubiquitous expression of YY1, Rex1 is expressed only during spermatogenesis and early embryogenesis and also in a very limited area of the placenta. Yet, the gene dosage of Rex1 is very critical for the survival of the late-stage embryos and neonates. This delayed phenotypic consequence suggests potential roles for Rex1 in establishing and maintaining unknown epigenetic …

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S11rs Sgr No. 8 (Gender), Taylor, Hill, Voss, Lockwood, Kelly, Alexander, Wedig, Vaughn, Gist, Duckett, Bourg, Soileau, Hebert, Harding, Lemoine, Simon, Caffarel

Student Senate Enrolled Legislation

No abstract provided.

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Tripodfish (Aulopiformes: Bathypterois) Locomotion And Landing Behaviour From Video Observation At Bathypelagic Depths In The Campos Basin Of Brazil, Matthew P. Davis, Prosanta Chakrabarty

Faculty Publications

A video observation of a deep-sea tripodfish (Aulopiformes: Bathypterois) taken from a remotely-operated vehicle at a depth of 1443 m in the Campos Basin, Brazil is analysed for swimming and landing movements. The observed specimen is identified here as Bathypteroisgrallator, and this record is the first video observation of a tripodfish exhibiting periodic swimming followed by landing in a resting position on deep-sea substrate which we interpret as ‘bathypteroiform’ movement, a locomotive mode unique to taxa within Bathypterois. This observation describes the functional role of the fins associated with landing, including independent movements of the elongated fin ray elements. The …

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Louisiana Agriculture Spring, 2011, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

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Ratiometric Coumarin-Neutral Red (Coner) Nanoprobe For Detection Of Hydroxyl Radicals, Gabriela M. Ganea, Paulina E. Kolic, Bilal El-Zahab, Isiah M. Warner

Faculty Publications

Excessive production of reactive oxygen species can lead to alteration of cellular functions responsible for many diseases including cardiovascular diseases, neurodegenerative diseases, cancer, and aging. Hydroxyl radical is a short-lived radical which is considered very aggressive due to its high reactivity toward biological molecules. In this study, a COumarin-NEutral Red (CONER) nanoprobe was developed for detection of hydroxyl radical based on the ratiometric fluorescence signal between 7-hydroxy coumarin 3-carboxylic acid and neutral red dyes. Biocompatible poly lactide-co-glycolide (PLGA) nanoparticles containing encapsulated neutral red were produced using a coumarin 3-carboxylic acid conjugated poly(sodium N-undecylenyl-Nε-lysinate) (C3C-poly-Nε- SUK) as moiety reactive to hydroxyl …

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Environmentally Persistent Free Radicals Decrease Cardiac Function Before And After Ischemia/Reperfusion Injury In Vivo, Kevin Lord, David Moll, John K. Lindsey, Sarah Mahne, Girija Raman, Tammy Dugas, Stephania Cormier, Dana Troxlair, Slawo Lomnicki, Barry Dellinger, Kurt Varner

Faculty Publications

Exposure to airborne particles is associated with increased cardiovascular morbidity and mortality. During the combustion of chlorine-containing hazardous materials and fuels, chlorinated hydrocarbons chemisorb to the surface of transition metal-oxide-containing particles, reduce the metal, and form an organic free radical. These radical-particle systems can survive in the environment for days and are called environmentally persistent free radicals (EPFRs). This study determined whether EPFRs could decrease left ventricular function before and after ischemia and reperfusion (I/R) in vivo. Male Brown-Norway rats were dosed (8mg/kg, intratracheal) 24h prior to testing with particles containing the EPFR of 1, 2-dichlorobenzene (DCB230). DCB230 treatment decreased …

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Skeletal Muscle Mitochondrial Capacity And Insulin Resistance In Type 2 Diabetes, Sudip Bajpeyi, Magdalena Pasarica, Cedric Moro, Kevin Conley, Sharon Jubrias, Olga Sereda, David H. Burk, Zhengyu Zhang, Alok Gupta, Lise Kjems, Steven R. Smith

Faculty Publications

Objective: The objective of this study was to determine the role of maximum mitochondrial capacity on the variation in insulin sensitivity within a population of patients with type 2 diabetes mellitus (T2DM). Research Design and Methods: Fifty-eight participants enrolled in a cross-sectional design: eight active controls [maximum aerobic capacity (VO2max) . 40 ml/kg . min], 17 healthy sedentary controlswithout a family history (FH-) and seven with a family history (FH+) of diabetes, four obese participants, and 21 patients with T2DM. Mitochondrial capacity was measured noninvasively using 31P magnetic resonance spectroscopy of the vastus lateralis. Maximal ATP synthetic rate (ATPmax) was …

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Visual Cues Are Relevant In Behavioral Control Measures For Cosmopolites Sordidus (Coleoptera: Curculionidae), Gadi V.P. Reddy, A. Raman

Faculty Publications

Trap designs for banana root borer, Cosmopolites sordidus (Germar) (Coleoptera: Curculionidae), have been done essentially on the understanding that C. sordidus rely primarily on chemical cues. Our present results indicate that these borers also rely on visual cues. Previous studies have demonstrated that among the eight differently colored traps tested in the field, brown traps were the most effective compared with the performances of yellow, red, gray, blue, black, white, and green traps; mahogany-brown was more effective than other shades of brown. In the current study, efficiency of ground traps with different colors was evaluated in the laboratory for the …

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Attitudes Toward Education: Parental Involvement And Family Structure, Claire Hanchey

Honors Capstones

No abstract provided.

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The Role Of Symmetry In The Regulation Of Bacterial Carboxyltransferase, Grover L. Waldrop

Faculty Publications

Carboxyltransferase is one component of the multifunctional enzyme acetyl-CoA carboxylase which catalyzes the first committed step in fatty acid biosynthesis. Carboxyltransferase is an α2β2 heterotetramer and possesses two distinct but integrated functions. One function catalyzes the transfer of carbon dioxide from biotin to acetyl-CoA, whereas the other involves binding to the mRNA encoding both subunits. When carboxyltransferase binds to the mRNA both enzymatic activity and translation of the mRNA are inhibited. However, the substrate acetyl-CoA competes with mRNA for binding. Thus, mRNA binding by carboxyltransferase provides an effective mechanism for regulating enzymatic activity and gene expression. This conceptual review takes …

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S11rs Sgfb No. 8 (Grad Symposium), Trout, Toumbeva, Marks, Hebert, Hills

Student Senate Enrolled Legislation

No abstract provided.

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The Immunophenotypic And Cytokine Characterization Of The Osteoarthritic Human Patellar Fat Pad: Comparison To Subcutaneous Adipose Tissue, Katie Marie Hamel

Honors Capstones

No abstract provided.

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The Sacrum Of The Poole-Rose Ossuary: Health Status, Variation, And Demography, Elizabeth A. Moffett

Honors Capstones

No abstract provided.

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Sediment History From K‟Ak‟ Naab‟ Column Sample 2: Human-Environment Interaction At A Classic Period Maya Salt Works Site, Jessica Harrison

Honors Capstones

No abstract provided.

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Nuclear Versus Mitochondrial Dna: Evidence For Hybridization In Colobine Monkeys, Christian Roos, Dietmar Zinner, Laura S. Kubatko, Christiane Schwarz, Mouyu Yang, Dirk Meyer, Stephen D. Nash, Jinchuan Xing, Mark A. Batzer, Markus Brameier, Fabian H. Leendertz, Thomas Ziegler, Dyah Perwitasari-Farajallah, Tilo Nadler, Lutz Walter, Martin Osterholz

Faculty Publications

Background: Colobine monkeys constitute a diverse group of primates with major radiations in Africa and Asia. However, phylogenetic relationships among genera are under debate, and recent molecular studies with incomplete taxon-sampling revealed discordant gene trees. To solve the evolutionary history of colobine genera and to determine causes for possible gene tree incongruences, we combined presence/absence analysis of mobile elements with autosomal, X chromosomal, Y chromosomal and mitochondrial sequence data from all recognized colobine genera. Results: Gene tree topologies and divergence age estimates derived from different markers were similar, but differed in placing Piliocolobus/Procolobus and langur genera among colobines. Although insufficient …

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Stem Cell Factor And Granulocyte Colony-Stimulating Factor Reduce Β-Amyloid Deposits In The Brains Of App/Ps1 Transgenic Mice, Bin Li, Maria E. Gonzalez-Toledo, Chun Shu Piao, Allen Gu, Roger E. Kelley, Li Ru Zhao

Faculty Publications

Introduction. Alzheimer's disease (AD) is widely recognized as a serious public health problem and heavy financial burden. Currently, there is no treatment that can delay or stop the progressive brain damage in AD. Recently, we demonstrated that stem cell factor (SCF) in combination with granulocyte colony-stimulating factor (G-CSF) (SCF+G-CSF) has therapeutic effects on chronic stroke. The purpose of the present study is to determine whether SCF+G-CSF can reduce the burden of β-amyloid deposits in a mouse model of AD. Methods. APP/PS1 transgenic mice were used as the model of AD. To track bone marrow-derived cells in the brain, the bone …

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Expression And Localization Of Clc Chloride Transport Proteins In The Avian Retina, Emily Mcmains, Vijai Krishnan, Sujitha Prasad, Evanna Gleason

Faculty Publications

Members of the ubiquitously expressed CLC protein family of chloride channels and transporters play important roles in regulating cellular chloride and pH. The CLCs that function as Cl-/H+ antiporters, ClCs 3-7, are essential in particular for the acidification of endosomal compartments and protein degradation. These proteins are broadly expressed in the nervous system, and mutations that disrupt their expression are responsible for several human genetic diseases. Furthermore, knock-out of ClC3 and ClC7 in the mouse result in the degeneration of the hippocampus and the retina. Despite this evidence of their importance in retinal function, the expression patterns of different CLC …

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Marr Homologs With Urate-Binding Signature, Inoka C. Perera, Anne Grove

Faculty Publications

Bacteria that associate with living hosts require intricate mechanisms to detect and respond to host defenses. Part of the early host defense against invading bacteria is the production of reactive oxygen species, and xanthine oxidase is one of the main producers of such agents. The end-product of the enzymatic activity of xanthine oxidase, urate, was previously shown to be the natural ligand for Deinococcus radiodurans-encoded HucR and it was shown to attenuate DNA binding by Agrobacterium tumefaciens-encoded PecS and Burkholderia thailandensis-encoded MftR, all members of the multiple antibiotic resistance regulator (MarR) family. We here show that residues involved in binding …

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Faculty Senate Newsletter, March 2011, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Message from President: Few would doubt that LSU and Louisiana higher education have made enormous progress over the last thirty-odd years. The notion that history progresses and that institutions advance has been out-of-fashion for aeons, yet it does seem that the onetime Old War Skule and its cohort campuses are doing a lot more in a much better way than they did at their inceptions. Sustaining the linear if not altogether teleological progress of Louisiana higher education, however, is the boom-and-bust cycle of the Louisiana economy, a cycle driven by the price of and demand for natural resources and related …

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The Utility Of Geometrical And Chemical Restraint Information Extracted From Predicted Ligand-Binding Sites In Protein Structure Refinement, Michal Brylinski, Seung Yup Lee, Hongyi Zhou, Jeffrey Skolnick

Faculty Publications

Exhaustive exploration of molecular interactions at the level of complete proteomes requires efficient and reliable computational approaches to protein function inference. Ligand docking and ranking techniques show considerable promise in their ability to quantify the interactions between proteins and small molecules. Despite the advances in the development of docking approaches and scoring functions, the genome-wide application of many ligand docking/screening algorithms is limited by the quality of the binding sites in theoretical receptor models constructed by protein structure prediction. In this study, we describe a new template-based method for the local refinement of ligand-binding regions in protein models using remotely …

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Findsite-Metal: Integrating Evolutionary Information And Machine Learning For Structure-Based Metal-Binding Site Prediction At The Proteome Level, Michal Brylinski, Jeffrey Skolnick

Faculty Publications

The rapid accumulation of gene sequences, many of which are hypothetical proteins with unknown function, has stimulated the development of accurate computational tools for protein function prediction with evolution/structure-based approaches showing considerable promise. In this article, we present FINDSITE-metal, a new threading-based method designed specifically to detect metal-binding sites in modeled protein structures. Comprehensive benchmarks using different quality protein structures show that weakly homologous protein models provide sufficient structural information for quite accurate annotation by FINDSITE-metal. Combining structure/evolutionary information with machine learning results in highly accurate metal-binding annotations; for protein models constructed by TASSER, whose average Cα RMSD from the …

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Generation Of Trophoblast Stem Cells From Rabbit Embryonic Stem Cells With Bmp4, Tao Tan, Xianghui Tang, Jing Zhang, Yuyu Niu, Hongwei Chen, Bin Li, Qiang Wei, Weizhi Ji

Faculty Publications

Trophoblast stem (TS) cells are ideal models to investigate trophectoderm differentiation and placental development. Herein, we describe the derivation of rabbit trophoblast stem cells from embryonic stem (ES) cells. Rabbit ES cells generated in our laboratory were induced to differentiate in the presence of BMP4 and TS-like cell colonies were isolated and expanded. These cells expressed the molecular markers of mouse TS cells, were able to invade, give rise to derivatives of TS cells, and chimerize placental tissues when injected into blastocysts. The rabbit TS-like cells maintained self-renewal in culture medium with serum but without growth factors or feeder cells, …

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Adjustment For Local Ancestry In Genetic Association Analysis Of Admixed Populations, Xuexia Wang, Xiaofeng Zhu, Huaizhen Qin, Richard S. Cooper, Warren J. Ewens, Chun Li, Mingyao Li

Faculty Publications

Motivation: Admixed populations offer a unique opportunity for mapping diseases that have large disease allele frequency differences between ancestral populations. However, association analysis in such populations is challenging because population stratification may lead to association with loci unlinked to the disease locus. Methods and results: We show that local ancestry at a test single nucleotide polymorphism (SNP) may confound with the association signal and ignoring it can lead to spurious association. We demonstrate theoretically that adjustment for local ancestry at the test SNP is sufficient to remove the spurious association regardless of the mechanism of population stratification, whether due to …

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On Local Times Of Anisotropic Gaussian Random Fields, Dongsheng Wu, Yimin Xiao

Communications on Stochastic Analysis

No abstract provided.

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Quantitative Environmental Benchmarking In A Hydrologically Driven Hawaiian Coastal System, Paul Bienfang, Suzanne De Felice, Edward A. Laws

Faculty Publications

The spatial and temporal variability of water quality within aquatic habitats in the Kaloko-Honokohau National Historical Park was examined over a 2-year period to quantitatively establish water quality benchmarks against which future data might be compared to test for evidence of anthropogenic impacts. Throughput of lowsalinity, high-nutrient groundwater and mixing with high-salinity, low-nutrient seawater caused significant temporal and spatial water quality variability in wells, anchialine pools, and fishponds within the study area. Variable mixing of seawater and freshwater was shown to be the primary determinant of changes in nutrient concentrations in these aquatic habitats, although leaching of basaltic rocks (Si) …

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Evidence For Mesenchymal-Epithelial Transition Associated With Mouse Hepatic Stem Cell Differentiation, Bin Li, Yun Wen Zheng, Yuuki Sano, Hideki Taniguchi

Faculty Publications

Mesenchymal-epithelial transition events are related to embryonic development, tissue construction, and wound healing. Stem cells are involved in all of these processes, at least in part. However, the direct evidence of mesenchymal-epithelial transition associated with stem cells is unclear. To determine whether mesenchymal-epithelial transition occurs in liver development and/or the differentiation process of hepatic stem cells in vitro, we analyzed a variety of murine liver tissues from embryonic day 11.5 to adults and the colonies derived from hepatic stem/progenitor cells isolated with flow cytometry. The results of gene expression, immunohistochemistry and Western blot showed that as liver develops, the expression …

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Full-Text Articles in Entire DC Network

Dental Genetic Traits Of Selected Maya Burials From Wild Cane Cay And Moho Cay, Belize, Kelly Heim

Honors Capstones

A Tutorial Of Manual Segmentation Using The Visualization Program Avizo® As Illustrated By The Skeleton Of The Spiny Dogfish Shark, Squalus Acanthias, Mateusz A. Lapucha

Honors Capstones

Modeling A Model Organism: The Lamprey, Petromyzon Marinus, Bradley M. Wood

Honors Capstones

Genomic Mechanisms Of Evolved Physiological Plasticity In Killifish Distributed Along An Environmental Salinity Gradient, Andrew Whitehead, Jennifer L. Roach, Shujun Zhang, Fernando Galvez

Faculty Publications

Rex1/Zfp42 As An Epigenetic Regulator For Genomic Imprinting, Jeong Do Kim, Hana Kim, Muhammad B. Ekram, Sungryul Yu, Christopher Faulk, Joomyeong Kim

Faculty Publications

S11rs Sgr No. 8 (Gender), Taylor, Hill, Voss, Lockwood, Kelly, Alexander, Wedig, Vaughn, Gist, Duckett, Bourg, Soileau, Hebert, Harding, Lemoine, Simon, Caffarel

Student Senate Enrolled Legislation

Tripodfish (Aulopiformes: Bathypterois) Locomotion And Landing Behaviour From Video Observation At Bathypelagic Depths In The Campos Basin Of Brazil, Matthew P. Davis, Prosanta Chakrabarty

Faculty Publications

Louisiana Agriculture Spring, 2011, Lsu Agcenter

Louisiana Agriculture

Ratiometric Coumarin-Neutral Red (Coner) Nanoprobe For Detection Of Hydroxyl Radicals, Gabriela M. Ganea, Paulina E. Kolic, Bilal El-Zahab, Isiah M. Warner

Faculty Publications

Environmentally Persistent Free Radicals Decrease Cardiac Function Before And After Ischemia/Reperfusion Injury In Vivo, Kevin Lord, David Moll, John K. Lindsey, Sarah Mahne, Girija Raman, Tammy Dugas, Stephania Cormier, Dana Troxlair, Slawo Lomnicki, Barry Dellinger, Kurt Varner

Faculty Publications

Skeletal Muscle Mitochondrial Capacity And Insulin Resistance In Type 2 Diabetes, Sudip Bajpeyi, Magdalena Pasarica, Cedric Moro, Kevin Conley, Sharon Jubrias, Olga Sereda, David H. Burk, Zhengyu Zhang, Alok Gupta, Lise Kjems, Steven R. Smith

Faculty Publications

Visual Cues Are Relevant In Behavioral Control Measures For Cosmopolites Sordidus (Coleoptera: Curculionidae), Gadi V.P. Reddy, A. Raman

Faculty Publications

Attitudes Toward Education: Parental Involvement And Family Structure, Claire Hanchey

Honors Capstones

The Role Of Symmetry In The Regulation Of Bacterial Carboxyltransferase, Grover L. Waldrop

Faculty Publications

S11rs Sgfb No. 8 (Grad Symposium), Trout, Toumbeva, Marks, Hebert, Hills

Student Senate Enrolled Legislation

The Immunophenotypic And Cytokine Characterization Of The Osteoarthritic Human Patellar Fat Pad: Comparison To Subcutaneous Adipose Tissue, Katie Marie Hamel

Honors Capstones

The Sacrum Of The Poole-Rose Ossuary: Health Status, Variation, And Demography, Elizabeth A. Moffett

Honors Capstones

Sediment History From K‟Ak‟ Naab‟ Column Sample 2: Human-Environment Interaction At A Classic Period Maya Salt Works Site, Jessica Harrison

Honors Capstones

Faculty Publications

Stem Cell Factor And Granulocyte Colony-Stimulating Factor Reduce Β-Amyloid Deposits In The Brains Of App/Ps1 Transgenic Mice, Bin Li, Maria E. Gonzalez-Toledo, Chun Shu Piao, Allen Gu, Roger E. Kelley, Li Ru Zhao

Faculty Publications

Expression And Localization Of Clc Chloride Transport Proteins In The Avian Retina, Emily Mcmains, Vijai Krishnan, Sujitha Prasad, Evanna Gleason

Faculty Publications

Marr Homologs With Urate-Binding Signature, Inoka C. Perera, Anne Grove

Faculty Publications

Faculty Senate Newsletter, March 2011, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

The Utility Of Geometrical And Chemical Restraint Information Extracted From Predicted Ligand-Binding Sites In Protein Structure Refinement, Michal Brylinski, Seung Yup Lee, Hongyi Zhou, Jeffrey Skolnick

Faculty Publications

Findsite-Metal: Integrating Evolutionary Information And Machine Learning For Structure-Based Metal-Binding Site Prediction At The Proteome Level, Michal Brylinski, Jeffrey Skolnick

Faculty Publications

Generation Of Trophoblast Stem Cells From Rabbit Embryonic Stem Cells With Bmp4, Tao Tan, Xianghui Tang, Jing Zhang, Yuyu Niu, Hongwei Chen, Bin Li, Qiang Wei, Weizhi Ji

Faculty Publications

Adjustment For Local Ancestry In Genetic Association Analysis Of Admixed Populations, Xuexia Wang, Xiaofeng Zhu, Huaizhen Qin, Richard S. Cooper, Warren J. Ewens, Chun Li, Mingyao Li

Faculty Publications

On Local Times Of Anisotropic Gaussian Random Fields, Dongsheng Wu, Yimin Xiao

Communications on Stochastic Analysis

Quantitative Environmental Benchmarking In A Hydrologically Driven Hawaiian Coastal System, Paul Bienfang, Suzanne De Felice, Edward A. Laws

Faculty Publications

Evidence For Mesenchymal-Epithelial Transition Associated With Mouse Hepatic Stem Cell Differentiation, Bin Li, Yun Wen Zheng, Yuuki Sano, Hideki Taniguchi

Faculty Publications