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Isothiocyanate-Rich Moringa Oleifera Extract Reduces Weight Gain, Insulin Resistance, And Hepatic Gluconeogenesis In Mice, Patricio Rojas-Silva, Tugba Boyunegmez Tumer, Peter Kuhn, Allison J. Richard, Shawna Wicks, Jacqueline M. Stephens, Zhong Wang, Randy Mynatt, William Cefalu, Ilya Raskin Jan 2015

Isothiocyanate-Rich Moringa Oleifera Extract Reduces Weight Gain, Insulin Resistance, And Hepatic Gluconeogenesis In Mice, Patricio Rojas-Silva, Tugba Boyunegmez Tumer, Peter Kuhn, Allison J. Richard, Shawna Wicks, Jacqueline M. Stephens, Zhong Wang, Randy Mynatt, William Cefalu, Ilya Raskin

Faculty Publications

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Scope: Moringa oleifera (moringa) is tropical plant traditionally used as an antidiabetic food. It produces structurally unique and chemically stable moringa isothiocyanates (MICs) that were evaluated for their therapeutic use in vivo. Methods and results: C57BL/6L mice fed very high fat diet (VHFD) supplemented with 5% moringa concentrate (MC, delivering 66 mg/kg/d of MICs) accumulated fat mass, had improved glucose tolerance and insulin signaling, and did not develop fatty liver disease compared to VHFD-fed mice. MC-fed group also had reduced plasma insulin, leptin, resistin, cholesterol, IL-1β, TNFα, and lower hepatic glucose-6-phosphatase …

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Tetrakis(P-Carboranylthio-Tetrafluorophenyl)Chlorin (Tpfc): Application For Photodynamic Therapy And Boron Neutron Capture Therapy, Ryo Hiramatsu, Shinji Kawabata, Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Koji Ono, Shin Ichi Miyatake, Toshihiko Kuroiwa, Erhong Hao, M. Graça H. Vicente Jan 2015

Tetrakis(P-Carboranylthio-Tetrafluorophenyl)Chlorin (Tpfc): Application For Photodynamic Therapy And Boron Neutron Capture Therapy, Ryo Hiramatsu, Shinji Kawabata, Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Koji Ono, Shin Ichi Miyatake, Toshihiko Kuroiwa, Erhong Hao, M. Graça H. Vicente

Faculty Publications

© 2014 Wiley Periodicals, Inc. Carboranyl-containing chlorins have emerged as promising dual sensitizers for use in both photodynamic therapy (PDT) and boron neutron capture therapy (BNCT), by virtue of their known tumor affinity, low cytotoxicity in dark conditions, and their strong absorptions in the red region of the optical spectrum. Tetrakis(p-carboranylthio-tetrafluorophenyl)chlorin (TPFC) is a new synthetic carboranyl-containing chlorin of high boron content (24% by weight). To evaluate TPFC's applicability as sensitizer for both PDT and BNCT, we performed an in vitro and in vivo study using F98 rat glioma cells and F98 rat glioma-bearing brain tumor models. For the in …

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Synthesis, Spectroscopic, And In Vitro Investigations Of 2,6-Diiodo-Bodipys With Pdt And Bioimaging Applications, Jaime H. Gibbs, Zehua Zhou, David Kessel, Frank R. Fronczek, Svetlana Pakhomova, M. Graҫa H. Vicente Jan 2015

Synthesis, Spectroscopic, And In Vitro Investigations Of 2,6-Diiodo-Bodipys With Pdt And Bioimaging Applications, Jaime H. Gibbs, Zehua Zhou, David Kessel, Frank R. Fronczek, Svetlana Pakhomova, M. Graҫa H. Vicente

Faculty Publications

© 2015 Elsevier B.V. All rights reserved. A series of five mono-styryl and their corresponding symmetric di-styryl-2,6-diiodo-BODIPYs containing indolyl, pyrrolyl, thienyl or tri(ethylene glycol)phenyl groups were synthesized using Knoevenagel condensations. The yields for the condensation reactions were improved up to 40% using microwave irradiation (90 °C for 1 h at 400 W) due to lower decomposition of BODIPYs upon prolonged heating. The spectroscopic, structural (including the X-ray of a di-styryl-2,6-diiodo-BODIPY) and in vitro properties of the BODIPYs were investigated. The extension of π-conjugation through the 3,5-dimethyls of the known phototoxic 2,6-diiodo-BODIPY 1 produced bathochromic shifts in the absorption and emission …

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Continent Formation Through Time, Nick M.W. Roberts, Martin J. Van Kranendonk, Stephen Parman, Peter D. Clift Jan 2015

Continent Formation Through Time, Nick M.W. Roberts, Martin J. Van Kranendonk, Stephen Parman, Peter D. Clift

Faculty Publications

© The Geological Society of London 2015. The continental crust is the primary archive of geological history, and is host to most of our natural resources. Thus, the following remain critical questions in Earth Science, and provide an underlying theme to all of the contributions within this volume: when, how and where did the continental crust form? How did it differentiate and evolve through time? How has it has been preserved in the geological record? This introductory review provides a background to these themes, and provides an outline of the contributions contained within this volume.

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Social Transitions Cause Rapid Behavioral And Neuroendocrine Changes, Karen P. Maruska Jan 2015

Social Transitions Cause Rapid Behavioral And Neuroendocrine Changes, Karen P. Maruska

Faculty Publications

© 2015 The Author 2015. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. In species that form dominance hierarchies, there are often opportunities for low-ranking individuals to challenge high-ranking ones, resulting in a rise or fall in social rank. How does an animal rapidly detect, process, and then respond to these social transitions? This article explores and summarizes how these social transitions can rapidly (within 24 h) impact an individual's behavior, physiology, and brain, using the African cichlid fish, Astatotilapia burtoni, as a model. Male A. burtoni form hierarchies in …

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Suppression Of Rnai By Dsrna-Degrading Rnaseiii Enzymes Of Viruses In Animals And Plants, Isabel Weinheimer, Yaming Jiu, Minna Liisa Rajamäki, Olli Matilainen, Jukka Kallijärvi, Wilmer J. Cuellar, Rui Lu, Mart Saarma, Carina I. Holmberg, Jussi Jäntti, Jari P.T. Valkonen Jan 2015

Suppression Of Rnai By Dsrna-Degrading Rnaseiii Enzymes Of Viruses In Animals And Plants, Isabel Weinheimer, Yaming Jiu, Minna Liisa Rajamäki, Olli Matilainen, Jukka Kallijärvi, Wilmer J. Cuellar, Rui Lu, Mart Saarma, Carina I. Holmberg, Jussi Jäntti, Jari P.T. Valkonen

Faculty Publications

© 2015 Weinheimer et al. Certain RNA and DNA viruses that infect plants, insects, fish or poikilothermic animals encode Class 1 RNaseIII endoribonuclease-like proteins. dsRNA-specific endoribonuclease activity of the RNaseIII of rock bream iridovirus infecting fish and Sweet potato chlorotic stunt crinivirus (SPCSV) infecting plants has been shown. Suppression of the host antiviral RNA interference (RNAi) pathway has been documented with the RNaseIII of SPCSV and Heliothis virescens ascovirus infecting insects. Suppression of RNAi by the viral RNaseIIIs in non-host organisms of different kingdoms is not known. Here we expressed PPR3, the RNaseIII of Pike-perch iridovirus, in the non-hosts Nicotiana …

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Co-Evolution Of Proteins And Solutions: Protein Adaptation Versus Cytoprotective Micromolecules And Their Roles In Marine Organisms, Paul H. Yancey, Joseph F. Siebenaller Jan 2015

Co-Evolution Of Proteins And Solutions: Protein Adaptation Versus Cytoprotective Micromolecules And Their Roles In Marine Organisms, Paul H. Yancey, Joseph F. Siebenaller

Faculty Publications

© 2015. Published by The Company of Biologists Ltd. Organisms experience a wide range of environmental factors such as temperature, salinity and hydrostatic pressure, which pose challenges to biochemical processes. Studies on adaptations to such factors have largely focused on macromolecules, especially intrinsic adaptations in protein structure and function. However, micromolecular cosolutes can act as cytoprotectants in the cellular milieu to affect biochemical function and they are now recognized as important extrinsic adaptations. These solutes, both inorganic and organic, have been best characterized as osmolytes, which accumulate to reduce osmotic water loss. Singly, and in combination, many cosolutes have properties …

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Standards For Plant Synthetic Biology: A Common Syntax For Exchange Of Dna Parts, Nicola J. Patron, Diego Orzaez, Sylvestre Marillonnet, Heribert Warzecha, Colette Matthewman, Mark Youles, Oleg Raitskin, Aymeric Leveau, Gemma Farré, Christian Rogers, Alison Smith, Julian Hibberd, Alex A.R. Webb, James Locke, Sebastian Schornack, Jim Ajioka, David C. Baulcombe, Cyril Zipfel, Sophien Kamoun, Jonathan D.G. Jones, Hannah Kuhn, Silke Robatzek, H. Peter Van Esse, Dale Sanders, Giles Oldroyd, Cathie Martin, Rob Field, Sarah O'Connor, Samantha Fox, Brande Wulff, Ben Miller, Andy Breakspear, Guru Radhakrishnan Jan 2015

Standards For Plant Synthetic Biology: A Common Syntax For Exchange Of Dna Parts, Nicola J. Patron, Diego Orzaez, Sylvestre Marillonnet, Heribert Warzecha, Colette Matthewman, Mark Youles, Oleg Raitskin, Aymeric Leveau, Gemma Farré, Christian Rogers, Alison Smith, Julian Hibberd, Alex A.R. Webb, James Locke, Sebastian Schornack, Jim Ajioka, David C. Baulcombe, Cyril Zipfel, Sophien Kamoun, Jonathan D.G. Jones, Hannah Kuhn, Silke Robatzek, H. Peter Van Esse, Dale Sanders, Giles Oldroyd, Cathie Martin, Rob Field, Sarah O'Connor, Samantha Fox, Brande Wulff, Ben Miller, Andy Breakspear, Guru Radhakrishnan

Faculty Publications

© 2015 New Phytologist Trust. Inventors in the field of mechanical and electronic engineering can access multitudes of components and, thanks to standardization, parts from different manufacturers can be used in combination with each other. The introduction of BioBrick standards for the assembly of characterized DNA sequences was a landmark in microbial engineering, shaping the field of synthetic biology. Here, we describe a standard for Type IIS restriction endonuclease-mediated assembly, defining a common syntax of 12 fusion sites to enable the facile assembly of eukaryotic transcriptional units. This standard has been developed and agreed by representatives and leaders of the …

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Diosgenin, 4-Hydroxyisoleucine, And Fiber From Fenugreek: Mechanisms Of Actions And Potential Effects On Metabolic Syndrome, Scott Fuller, Jacqueline M. Stephens Jan 2015

Diosgenin, 4-Hydroxyisoleucine, And Fiber From Fenugreek: Mechanisms Of Actions And Potential Effects On Metabolic Syndrome, Scott Fuller, Jacqueline M. Stephens

Faculty Publications

© 2015 American Society for Nutrition. Metabolic syndrome and its complications continue to rise in prevalence and show no signs of abating in the immediate future. Therefore, the search for effective treatments is a high priority in biomedical research. Products derived from botanicals have a time-honored history of use in the treatment of metabolic diseases including type 2 diabetes. Trigonella foenum-graecum, commonly known as fenugreek, is an annual herbaceous plant that has been a staple of traditional herbal medicine in many cultures. Although fenugreek has been studied in both clinical and basic research settings, questions remain about its efficacy and …

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Fat In Flames: Influence Of Cytokines And Pattern Recognition Receptors On Adipocyte Lipolysis, Ryan W. Grant, Jacqueline M. Stephens Jan 2015

Fat In Flames: Influence Of Cytokines And Pattern Recognition Receptors On Adipocyte Lipolysis, Ryan W. Grant, Jacqueline M. Stephens

Faculty Publications

© 2015 the American Physiological Society. Adipose tissue has the largest capacity to store energy in the body and provides energy through the release of free fatty acids during times of energy need. Different types of immune cells are recruited to adipose tissue under various physiological conditions, indicating that these cells contribute to the regulation of adipose tissue. One major pathway influenced by a number of immune cells is the release of free fatty acids through lipolysis during both physiological (e.g., cold stress) and pathophysiological processes (e.g., obesity, type 2 diabetes). Adipose tissue expansion during obesity leads to immune cell …

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Seasonal Changes In Soil Organic Matter After A Decade Of Nutrient Addition In A Lowland Tropical Forest, Benjamin L. Turner, Joseph B. Yavitt, Kyle E. Harms, Milton N. Garcia, S. Joseph Wright Jan 2015

Seasonal Changes In Soil Organic Matter After A Decade Of Nutrient Addition In A Lowland Tropical Forest, Benjamin L. Turner, Joseph B. Yavitt, Kyle E. Harms, Milton N. Garcia, S. Joseph Wright

Faculty Publications

© 2015, US Government. Soil organic matter is an important pool of carbon and nutrients in tropical forests. The majority of this pool is assumed to be relatively stable and to turn over slowly over decades to centuries, although changes in nutrient status can influence soil organic matter on shorter timescales. We measured carbon, nitrogen, and phosphorus concentrations in soil organic matter and leaf litter over an annual cycle in a long-term nutrient addition experiment in lowland tropical rain forest in the Republic of Panama. Total soil carbon was not affected by a decade of factorial combinations of nitrogen, phosphorus, …

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Fuels And Fires Influence Vegetation Via Above- And Belowground Pathways In A High-Diversity Plant Community, Paul R. Gagnon, Heather A. Passmore, Matthew Slocum, Jonathan A. Myers, Kyle E. Harms, William J. Platt, C. E.Timothy Paine Jan 2015

Fuels And Fires Influence Vegetation Via Above- And Belowground Pathways In A High-Diversity Plant Community, Paul R. Gagnon, Heather A. Passmore, Matthew Slocum, Jonathan A. Myers, Kyle E. Harms, William J. Platt, C. E.Timothy Paine

Faculty Publications

© 2015 British Ecological Society. Fire strongly influences plant populations and communities around the world, making it an important agent of plant evolution. Fire influences vegetation through multiple pathways, both above- and belowground. Few studies have yet attempted to tie these pathways together in a mechanistic way through soil heating even though the importance of soil heating for plants in fire-prone ecosystems is increasingly recognized. Here we combine an experimental approach with structural equation modelling (SEM) to simultaneously examine multiple pathways through which fire might influence herbaceous vegetation. In a high-diversity longleaf pine groundcover community in Louisiana, USA, we manipulated …

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Are Receptor Concentrations Correlated Across Tissues Within Individuals? A Case Study Examining Glucocorticoid And Mineralocorticoid Receptor Binding, Christine R. Lattin, Daniel E. Keniston, J. Michael Reed, L. Michael Romero Jan 2015

Are Receptor Concentrations Correlated Across Tissues Within Individuals? A Case Study Examining Glucocorticoid And Mineralocorticoid Receptor Binding, Christine R. Lattin, Daniel E. Keniston, J. Michael Reed, L. Michael Romero

Faculty Publications

Copyright © 2015 by the Endocrine Society. Hormone receptors are a necessary (although not sufficient) part of the process through which hormones like corticosterone create physiological responses. However, it is currently unknown to what extent receptor concentrations across different target tissues may be correlated within individual animals. In this study, we examined this question using a large dataset of radioligand binding data for glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs) in 13 different tissues in the house sparrow (Passer domesticus) (n = 72). Our data revealed that individual house sparrows tended to exhibit higher or lower receptor binding across all …

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Centimeter-Long Electron Transport In Marine Sediments Via Conductive Minerals, Nikhil S. Malvankar, Gary M. King, Derek R. Lovley Jan 2015

Centimeter-Long Electron Transport In Marine Sediments Via Conductive Minerals, Nikhil S. Malvankar, Gary M. King, Derek R. Lovley

Faculty Publications

© 2015 International Society for Microbial Ecology All rights reserved. Centimeter-long electron conduction through marine sediments, in which electrons derived from sulfide in anoxic sediments are transported to oxygen in surficial sediments, may have an important influence on sediment geochemistry. Filamentous bacteria have been proposed to mediate the electron transport, but the filament conductivity could not be verified and other mechanisms are possible. Surprisingly, previous investigations have never actually measured the sediment conductivity or its basic physical properties. Here we report direct measurements that demonstrate centimeter-long electron flow through marine sediments, with conductivities sufficient to account for previously estimated electron …

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Physiological Profiles As Indicators Of Response To Hurricane Disturbance For Three Coastal Wetland Species, Alexandria Lynn Pivovaroff, Cheryl Swift, Loretta L. Battaglia, Brittany Kunz, William J. Platt, Carrie L. Yoder Jan 2015

Physiological Profiles As Indicators Of Response To Hurricane Disturbance For Three Coastal Wetland Species, Alexandria Lynn Pivovaroff, Cheryl Swift, Loretta L. Battaglia, Brittany Kunz, William J. Platt, Carrie L. Yoder

Faculty Publications

© Coastal Education & Research Foundation 2015. Hurricanes alter light and water availability via canopy damage and storm surge delivery and are expected to intensify with climate change. Plant species respond to environmental changes by making physiological adjustments in situ or through distribution changes. Three years after Hurricane Katrina, we compared functional traits and water relations among three species along the coenocline at Weeks Bay National Estuarine Research Reserve, Fairhope, Alabama, U.S.A. Based on posthurricane distribution changes for these species, we hypothesized that (1) Cladium mariscus, whose distribution expanded slightly, is responsive to increased light availability in the disturbed forest …

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Discordance Between Morphological And Molecular Species Boundaries Among Caribbean Species Of The Reef Sponge Callyspongia, Melissa B. Debiasse, Michael E. Hellberg Jan 2015

Discordance Between Morphological And Molecular Species Boundaries Among Caribbean Species Of The Reef Sponge Callyspongia, Melissa B. Debiasse, Michael E. Hellberg

Faculty Publications

© 2015 The Authors. Sponges are among the most species-rich and ecologically important taxa on coral reefs, yet documenting their diversity is difficult due to the simplicity and plasticity of their morphological characters. Genetic attempts to identify species are hampered by the slow rate of mitochondrial sequence evolution characteristic of sponges and some other basal metazoans. Here we determine species boundaries of the Caribbean coral reef sponge genus Callyspongia using a multilocus, model-based approach. Based on sequence data from one mitochondrial (COI), one ribosomal (28S), and two single-copy nuclear protein-coding genes, we found evolutionarily distinct lineages were not concordant with …

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Fishes Of The Eastern Johor Strait, Heok Hee Ng, Heok Hui Tan, Kelvin K.P. Lim, William B. Ludt, Prosanta Chakrabarty Jan 2015

Fishes Of The Eastern Johor Strait, Heok Hee Ng, Heok Hui Tan, Kelvin K.P. Lim, William B. Ludt, Prosanta Chakrabarty

Faculty Publications

© National University of Singapore. We record the presence of 435 fish species from the Eastern Johor Strait based on our fieldwork, a review of the existing literature, and an examination of photographs and museum specimens. Four species are recorded for the first time from the waters of Singapore: Pseudorhombus elevatus (Paralichthyidae), Heteromycteris hartzfeldii (Soleidae), Nuchequula manusella (Leiognathidae) and Johnius carouna (Sciaenidae).

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Yeast High Mobility Group Protein Hmo1 Stabilizes Chromatin And Is Evicted During Repair Of Dna Double Strand Breaks, Arvind Panday, Li Juan Xiao, Anne Grove Jan 2015

Yeast High Mobility Group Protein Hmo1 Stabilizes Chromatin And Is Evicted During Repair Of Dna Double Strand Breaks, Arvind Panday, Li Juan Xiao, Anne Grove

Faculty Publications

© The Author(s) 2015. DNA is packaged into condensed chromatin fibers by association with histones and architectural proteins such as high mobility group (HMGB) proteins. However, this DNA packaging reduces accessibility of enzymes that act on DNA, such as proteins that process DNA after double strand breaks (DSBs). Chromatin remodeling overcomes this barrier. We show here that the Saccharomyces cerevisiae HMGB protein HMO1 stabilizes chromatin as evidenced by faster chromatin remodeling in its absence. HMO1 was evicted along with core histones during repair of DSBs, and chromatin remodeling events such as histone H2A phosphorylation and H3 eviction were faster in …

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Derivation Of The Freshwater Fish Fauna Of Central America Revisited: Myers's Hypothesis In The Twenty-First Century, Wilfredo A. Matamoros, Caleb D. Mcmahan, Prosanta Chakrabarty, James S. Albert, Jacob F. Schaefer Jan 2015

Derivation Of The Freshwater Fish Fauna Of Central America Revisited: Myers's Hypothesis In The Twenty-First Century, Wilfredo A. Matamoros, Caleb D. Mcmahan, Prosanta Chakrabarty, James S. Albert, Jacob F. Schaefer

Faculty Publications

© The Willi Hennig Society 2014. Although attempts to understand Central American freshwater fish provincialism date to the 1960s, early efforts lacked the wealth of distributional data now available. Biogeographic work on Central American freshwater fishes has been largely descriptive and regional, and lacked a broader synthesis. Here we use parsimony analysis of endemicity (PAE) to elucidate faunistic relationships between major drainages and to delineate areas of endemism. We then perform a Brooks parsimony analysis (BPA) on the resulting areas. The PAE recovered a primary division between four Pacific and six Atlantic slope areas of endemism. In contrast, the BPA …

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Helicase And Its Interacting Factors: Regulation Mechanism, Characterization, Structure, And Application For Drug Design, Cheng Yang Huang, Yoshito Abe, Huangen Ding, I. Fang Chung Jan 2015

Helicase And Its Interacting Factors: Regulation Mechanism, Characterization, Structure, And Application For Drug Design, Cheng Yang Huang, Yoshito Abe, Huangen Ding, I. Fang Chung

Faculty Publications

No abstract provided.

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Reduction Of Mitochondrial Protein Mitoneet [2fe-2s] Clusters By Human Glutathione Reductase, Aaron P. Landry, Zishuo Cheng, Huangen Ding Jan 2015

Reduction Of Mitochondrial Protein Mitoneet [2fe-2s] Clusters By Human Glutathione Reductase, Aaron P. Landry, Zishuo Cheng, Huangen Ding

Faculty Publications

© 2015 Elsevier Inc. All rights reserved. The human mitochondrial outer membrane protein mitoNEET is a newly discovered target of the type 2 diabetes drug pioglitazone. Structurally, mitoNEET is a homodimer with each monomer containing an N-terminal transmembrane α helix tethered to the mitochondrial outer membrane and a C-terminal cytosolic domain hosting a redox-active [2Fe-2S] cluster. Genetic studies have shown that mitoNEET has a central role in regulating energy metabolism in mitochondria. However, the specific function of mitoNEET remains largely elusive. Here we find that the mitoNEET [2Fe-2S] clusters can be efficiently reduced by Escherichia coli thioredoxin reductase and glutathione …

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Discovery And Confirmation Of Genes/Proteins Associated With Maize Aflatoxin Resistance, Z. Y. Chen, K. Rajasekaran, R. L. Brown, R. J. Sayler, D. Bhatnagar Jan 2015

Discovery And Confirmation Of Genes/Proteins Associated With Maize Aflatoxin Resistance, Z. Y. Chen, K. Rajasekaran, R. L. Brown, R. J. Sayler, D. Bhatnagar

Faculty Publications

Maize (Zea mays L.) is one of the major crops susceptible to Aspergillus flavus infection and subsequent aflatoxin contamination. Many earlier studies indicated the roles of kernel proteins, especially constitutively expressed proteins, in maize resistance to A. flavus infection and aflatoxin production. In this review, we examined the past and current efforts in identifying maize genes and proteins from kernel, rachis, and silk tissues that may play an important role in resistance to A. flavus infection and aflatoxin contamination, as well as the efforts in determining the importance or involvement of them in maize resistance through biochemical, molecular and genetics …

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Atoxigenic Aspergillus Flavus Biological Control Of Aflatoxin Contamination: What Is The Mechanism?, K. E. Damann Jan 2015

Atoxigenic Aspergillus Flavus Biological Control Of Aflatoxin Contamination: What Is The Mechanism?, K. E. Damann

Faculty Publications

The term 'competitive exclusion' involving physical blockage of growth or access of the toxigenic strain to the seed target has been used to describe the mechanism of biological control of aflatoxin contamination. However, recent evidence suggests that a form of intraspecific aflatoxin inhibition requiring growth of the competing strains together during the infection process in such a way that hyphae physically interact or touch is the trigger for preventing induction of aflatoxin synthesis. This direct touch-based inhibition of aflatoxin synthesis is posited to be the mechanistic basis of biological control in this system. Evidence for this idea comes from the …

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Structure Activity Relationships Of Biotin Carboxyl Carrier Protein Of E. Coli Acetyl-Coa Carboxylase, Amanda Breaux Jan 2015

Structure Activity Relationships Of Biotin Carboxyl Carrier Protein Of E. Coli Acetyl-Coa Carboxylase, Amanda Breaux

Honors Capstones

No abstract provided.

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Components, Volume 11 (2015), Lsu Center For Computation And Technology Jan 2015

Components, Volume 11 (2015), Lsu Center For Computation And Technology

Components

No abstract provided.

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2015 Annual Report, Louisiana Rice Research Board, Lsu Agcenter Jan 2015

2015 Annual Report, Louisiana Rice Research Board, Lsu Agcenter

Louisiana Rice Research Board Annual Report

No abstract provided.

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Lsu General Catalog 2015-2016, Louisiana State University And Agricultural And Mechanical College Jan 2015

Lsu General Catalog 2015-2016, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The LSU General Catalog includes information on registration and financial aid as well as academic services offered to all students.

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A Bayesian Phase I/Ii Clinical Trial Design In The Presence Of Informative Dropouts, Beibei Guo, Yong Zang, Ying Yuan Jan 2015

A Bayesian Phase I/Ii Clinical Trial Design In The Presence Of Informative Dropouts, Beibei Guo, Yong Zang, Ying Yuan

Faculty Publications

A phase I/II trial design utilizes both toxicity and efficacy outcomes to make the decision of dose assignment for patients. Because assessing the efficacy endpoint often requires a relatively long follow-up time, phase I/II trials are more susceptible to the missing data problem caused by informative dropouts that are correlated with treatment efficacy and toxicity. In addition, patient outcomes may not be scored quickly enough to apply decision rules that choose treatments or doses for newly accrued patients. To address these issues, we propose a Bayesian phase I/II design that jointly models efficacy, toxicity, and dropout as time-to-event data. Correlations …

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The Many Chances Of Charles Darwin, Charles H. Pence Jan 2015

The Many Chances Of Charles Darwin, Charles H. Pence

Faculty Publications

No abstract provided.

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Is Organismic Fitness At The Basis Of Evolutionary Theory?, Charles H. Pence, Grant Ramsey Jan 2015

Is Organismic Fitness At The Basis Of Evolutionary Theory?, Charles H. Pence, Grant Ramsey

Faculty Publications

Fitness is a central theoretical concept in evolutionary theory. Despite its importance, much debate has occurred over how to conceptualize and formalize fitness. One point of debate concerns the roles of organismic and trait fitness. In a recent addition to this debate, Elliott Sober argues that trait fitness is the central fitness concept, and that organismic fitness is of little value. In this paper, by contrast, we argue that it is organismic fitness that lies at the bases of both the conceptual role of fitness and its role as a measure of evolutionary dynamics.

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