Digital Commons Network^™

Effects Of Exercise Or Metformin On Myokine Concentrations In Patients With Breast And Colorectal Cancer: A Phase Ii Multi-Centre Factorial Randomized Trial, Justin C. Brown, Guillaume Spielmann, Shengping Yang, Stephanie L.E. Compton, Lee W. Jones, Melinda L. Irwin, Jennifer A. Ligibel, Jeffrey A. Meyerhardt

Faculty Publications

Background: Physical activity and metformin pharmacotherapy are associated with improved clinical outcomes in breast and colorectal cancer survivors. Myokines are cytokines secreted from skeletal muscle that may mediate these associations. Methods: This hypothesis-generating analysis used biospecimens collected from a multi-centre 2 × 2 factorial randomized design of 116 patients with stage I–III breast and colorectal cancer who were randomized to 12 weeks of (1) aerobic exercise (moderate intensity titrated to 220 min/week); (2) metformin (850 mg daily for 2 weeks and then titrated to 850 mg twice per day); (3) aerobic exercise and metformin; or (4) control. Fourteen myokines were …

Boron Neutron Capture Therapy Of Cancer: Where Do We Stand Now?, Rolf F. Barth, Gong Wu, Maria Da Graca H. Vicente, John C. Grecula, Nilendu Gupta

Faculty Publications

No abstract provided.

Acute Pancreatitis In Individuals With Sickle Cell Disease: A Systematic Review, Chinenye R. Dike, Adefunke Dadematthews, Oluwagbemiga Dadematthews, Maisam Abu-El-Haija, Jeffrey Lebensburger, Abigail Smith, Aamer Imdad

Faculty Publications

Background/Objectives: Sickle cell disease (SCD) impacts about 100,000 people in the US. SCD increases the risk of cholelithiasis and microvascular ischemia, which could increase the risk of acute pancreatitis (AP). Abdominal pain is a common presenting symptom of AP and sickle cell vaso-occlusive crisis. The purpose of our systematic review is to estimate the prevalence and determine the severity of AP in individuals with SCD compared to the general population. Methods: Multiple electronic databases were searched. We included studies that included children and adults (population) and addressed the association of SCD (exposure) with AP (outcome) compared to the same population …

Learning Nonlinear Dynamics In Synchronization Of Knowledge-Based Leader-Following Networks, Shimin Wang, Xiangyu Meng, Hongwei Zhang, Frank L. Lewis

Faculty Publications

Knowledge-based leader-following synchronization of heterogeneous nonlinear multi-agent systems is a challenging problem since the leader's dynamic information is unknown to any follower node. This paper proposes a learning-based fully distributed observer for a class of nonlinear leader systems, which can simultaneously learn the leader's dynamics and states. This class of leader dynamics is rather general and does not require a bounded Jacobian matrix. Based on this learning-based distributed observer, we further synthesize an adaptive distributed control law for solving the leader-following synchronization problem of multiple Euler–Lagrange systems subject to an uncertain nonlinear leader system. The results are illustrated by a …

Lipids To The Rescue In Pulmonary Fibrosis: Biosynthesis, Bioenergetics, Or Epigenetics?, Manas Ranjan Gartia, Victor J. Thannickal

Faculty Publications

No abstract provided.

Hyperpolarized Magnetic Resonance Imaging, Nuclear Magnetic Resonance Metabolomics, And Artificial Intelligence To Interrogate The Metabolic Evolution Of Glioblastoma, Kang Lin Hsieh, Qing Chen, Travis C. Salzillo, Jian Zhang, Xiaoqian Jiang, Pratip K. Bhattacharya, Shyan Shams

Faculty Publications

Glioblastoma (GBM) is a malignant Grade VI cancer type with a median survival duration of only 8–16 months. Earlier detection of GBM could enable more effective treatment. Hyperpolarized magnetic resonance spectroscopy (HPMRS) could detect GBM earlier than conventional anatomical MRI in glioblastoma murine models. We further investigated whether artificial intelligence (A.I.) could detect GBM earlier than HPMRS. We developed a deep learning model that combines multiple modalities of cancer data to predict tumor progression, assess treatment effects, and to reconstruct in vivo metabolomic information from ex vivo data. Our model can detect GBM progression two weeks earlier than conventional MRIs …

The Impact Of Lutein-Loaded Poly(Lactic-Coglycolic Acid) Nanoparticles Following Topical Application: An In Vitro And In Vivo Study, Renee T. Carter, Sean Swetledge, Sara Navarro, Chin C. Liu, Nikole Ineck, Andrew C. Lewin, Fabrizio Donnarumma, Ede Bodoki, Rhett W. Stout, Carlos Astete, Jangwook P. Jung, Cristina M. Sabliov

Faculty Publications

Antioxidant therapies are of interest in the prevention and management of ocular disorders such as cataracts. Although an active area of interest, topical therapy with antioxidants for the treatment of cataracts is complicated by multiple ocular anatomical barriers, product stability, and solubility. Entrapment and delivery of antioxidants with poly(lactic-co-glycolic acid) nanoparticles is a possible solution to these challenges, however, little is known regarding their effects in vitro or in vivo. Our first aim was to investigate the impact of blank and lutein loaded PLGA nanoparticles on viability and development of reactive oxygen species in lens epithelial cells in vitro. Photo-oxidative …

Development Of Satellite-Assisted Forecasting System For Vibrio Vulnificus Prevalence In Coastal Waters, Saber Aradpour

LSU Doctoral Dissertations

Vibrio vulnificus is a halophilic gamma proteobacterium that is autochthonous to coastal waters and is responsible for 50% of seafood-related deaths in the United States. This study presents a series of nowcasting and forecasting models for predicting vibrio vulnificus abundance in oysters by identifying the long-range dependence of vibrio vulnificus abundance on antecedent environmental conditions and detecting the environmental conditions using satellite remote sensing technology. It was discovered that vibrio vulnificus abundance exhibits a long-range dependence on antecedent environmental conditions which can be characterized by seven independent environmental predictors (stressors) including sea surface temperature (SST), water level (WL), sea surface …

Central Lean Mass Distribution And The Risks Of All-Cause And Cause-Specific Mortality In 40,283 Uk Biobank Participants, Li Ding, Yuxin Fan, Jiaxing Wang, Xiaohui Ma, Lina Chang, Qing He, Gang Hu, Ming Liu

Population and Public Health Science Faculty Publications

Introduction: The purpose of this study was to investigate the association of central lean mass distribution with the risk of mortality. Methods: This cohort study included 40,283 UK Biobank participants. Cox proportional hazards regression models were used to estimate the association of central lean mass distribution, i.e., trunk-to-leg lean mass ratio, assessed by dual-energy X-ray absorptiometry, with the risk of mortality. Results: The median age of the participants was 65 years, and 52% were women. During a median follow-up of 4.18 years, 674 participants died, of whom 366 were due to cancer and 126 were due to cardiovascular causes. Compared …

Ion-Mediated Structural Discontinuities In Phospholipid Vesicles, Judith U. De Mel, Stefanie Klisch, Sudipta Gupta, Gerald J. Schneider

Faculty Publications

Despite intense research, methods for controlling soft matter’s spontaneous self-assembly into well-defined layers remain a significant challenge. We observed ion-induced structural discontinuities of phospholipid vesicles that can be exploited for controlled self-assembly of soft materials, using DOPC and NaCl as a model system. The observations were made for the 0.25 wt % lipid concentration. We used dynamic light scattering, zeta-potential measurement, cryo-electron microscopy, small-angle X-ray, and small-angle neutron scattering to understand the reason for the discontinuities. For salt concentrations below 8 mM, we observed a decrease in the liposome diameter with increased NaCl concentration. Above 8 mM, we measured a …

Novel Approaches To The Activation Of Chalcogenoglycosides For O-Glycosylation, Tiffany Duong

LSU Doctoral Dissertations

Carbohydrates are integral to various biological processes such as cell signaling, function and regulation. Carbohydrates also play critical roles in various disease and metastatic pathways. This has garnered considerable attention to the field of glycoscience, however, the study of carbohydrate-containing compounds remains a challenge due to the difficulty in obtaining pure samples from natural sources. As a result, the biological evaluation of carbohydrates relies on synthetic chemistry to produce pure compounds in significant quantities. However, the synthesis of carbohydrates present their own challenges owing to the complexity in controlling stereochemistry and regiochemistry. The most significant of these challenges is controlling …

Susceptibility Of Spodoptera Frugiperda And Helicoverpa Zea Populations In The Southern Region Of The United States To Common Chemical Insecticides, Bhavana Patla

LSU Master's Theses

Abstract

The fall armyworm, Spodoptera frugiperda and corn earworm/bollworm, Helicoverpa zea, are two polyphagous pests prevalent in the U.S. In recent years, there were increased infestations of the two pests in the U.S., especially in its southern region. Information on the susceptibility/resistance status of the two pests in the region to chemical insecticides, especially to some new chemistries, is very limited or has not been updated for many years. In this study, susceptibility of 17 S. frugiperda and six H. zea field collected populations from the southern U.S. during 2021-23 to common insecticides was investigated in the laboratory. Dose-responses with …

An Analysis Of The Development Of Cognitive Control In Young Children Within An Auditory And Visual Modality., Lauren A. Schiro

LSU Master's Theses

The Dual Mechanisms of Cognitive Control Framework (DMC) posits that cognitive control is directed through two different modes: proactive and reactive control. Proactive control involves the maintenance and manipulation of information in preparation of a response while reactive control would involve little to no preparation until after a response prompt. The AX-Continuous Performance Task (AX-CPT) is a cognitive control task that is often utilized in studies looking at proactive and reactive control as it measures context processing and goal maintenance. The aims of this study were to validate the auditory version of the AX-CPT and to then apply this task …

The Behavioral Specialization Of African Ant-Following Birds On Dorylus Driver Ants, Patricia F. Rodrigues

LSU Doctoral Dissertations

Ant-following birds, that forage on arthropods flushed by swarm raiding army ants, are an iconic phenomenon in tropical forests around the globe. Despite capturing the attention of naturalists for over a century, research on ant-following birds has largely focused on Neotropical species. Decades of research on Neotropical ant-following birds has revealed fascinating aspects of their specialization, including complex cognitive and behavioral adaptations that allow birds to locate and track nomadic army ants. Despite this breadth of research on Neotropical species, virtually nothing is known of the behavioral ecology of African ant-following birds, and it remains unknown whether they exhibit adaptations …

An Exploration Of The Drivers Of Intraspecific Variation In Arthropod Phenotypes, Jamie Phelps

LSU Doctoral Dissertations

Herein we explore the various forces that drive phenotypic variation in arthropods focusing on spatial and temporal differences as well as sexual dimorphism. We use both marine, Tigriopus californicus, and terrestrial, Melitaeini, organisms to investigate these forces.

Tigriopus californicus and Heat Hardening: The study explores how Tigriopus californicus, a copepod, adapts to thermal variation along the North American Pacific Coast. Researchers investigated intraspecific variation in heat hardening, measuring differences in upper lethal limits (ULLs) and potential fecundity costs across five populations. We found a cost of heat hardening: the size of the first brood produced after heat shock …

Revisiting The Preparation And Catalytic Performance Of A Phosphine-Modified Co(Ii) Hydroformylation Precatalyst, David R. Holzknecht, Alexandra K. Van Alstine, Brandon P. Russell, David J. Vinyard, Fabrizio Donnarumma, Matthew B. Chambers

Faculty Publications

In light of recent conflicting reports regarding the hydroformylation catalytic activity derived from cationic Co(II) precatalysts of the form [Co(acac)(bis(phosphine))]BF4, the synthetic procedures and characterization of [Co(acac)(dppBz)]BF4, 1, are evaluated. Leveraging calibrated ESI-TOF MS methodologies, substantial quantities of Co(acac)2(dppBz), 2, were observed within samples of 1. The source of the impurity, 2, is determined to derive from incomplete protonolysis of the Co(acac)2 precursor and ligand scrambling occurring during the synthesis of 1. Revised synthetic procedures using lower temperature conditions and longer reaction times afford analytically pure samples of 1 based on ESI-TOF MS and NMR spectroscopic analysis. Complex 1 is …

Unveiling Competitive Adsorption In Tio2 Photocatalysis Through Machine-Learning-Accelerated Molecular Dynamics, Dft, And Experimental Methods, Omar Allam, Mostafa Maghsoodi, Seung Soon Jang, Samuel D. Snow

Faculty Publications

The efficient harnessing of solar power for water treatment via photocatalytic processes has long been constrained by the challenge of understanding and optimizing the interactions at the photocatalyst surface, particularly in the presence of nontarget cosolutes. The adsorption of these cosolutes, such as natural organic matter, onto photocatalysts can inhibit the degradation of pollutants, drastically decreasing the photocatalytic efficiency. In the present work, computational methods are employed to predict the inhibitory action of a suite of small organic molecules during TiO2 photocatalytic degradation of para-chlorobenzoic acid (pCBA). Specifically, tryptophan, coniferyl alcohol, succinic acid, gallic acid, and trimesic acid were selected …

Limit Theorems For Increments Of Branching Particle Systems With Linear Rates And Poisson Initial Condition, Alexander Kreinin, Vladimir V. Vinogradov

Journal of Stochastic Analysis

No abstract provided.

Examining Social Anxiety, Generalized Anxiety, And Major Depression’S Symptom Comorbidity In Children And Adolescents: A Longintudinal Test Of The Multiple Pathway Model, Paige Picou

LSU Doctoral Dissertations

Anxiety and depressive disorders are highly prevalent in and impairing for children and adolescents and are highly comorbid. Many theories have been proposed to explain this co- occurrence, with recent models postulating multiple pathways in which specific anxiety disorders and depression may co-occur both concurrently and over time. Unfortunately, little research has evaluated these pathways longitudinally across development in a community sample. The current study tested the multiple pathway model in a sample of 9 to 12-year-old youth (Mage = 9.48, SD= 0.51) at baseline and at two-year follow-up using a subsample of the Adolescent Brain Cognitive Development …

Advances In Stereoselective Glycosylation: Electron-Withdrawing Groups, Benzyne-Mediated Stereoinversion, And Visible-Light Photochemistry For 1,2-Cis O-Glycosylation, Erik Giovanni Alvarez Valenzuela

LSU Doctoral Dissertations

The symbiotic relationship between humans and their microbiota is essential for health, with imbalances in the complex microbiota ecosystem linked to a variety of disorders ranging from neurodegenerative to gastrointestinal diseases. Bacteria within the human microbiota, comprising over 1000 known species, are densely and diversely coated with oligosaccharides crucial for functions like cell recognition, communication, signaling, adhesion, proliferation, and pathogenic inhibition. However, studying the structure-activity relationships of these sugars which are also secreted by bacteria is challenging due to difficulties in obtaining homogenous samples from natural sources.

Chemical synthesis offers a solution by enabling the production of well-defined oligosaccharides in …

The Hydrological Impacts Of Woody Plant Encroachment On Coastal Tallgrass Prairie Of Texas, Zhiwei Guo

LSU Master's Theses

Globally, woody plant encroachment into grassland and savanna ecosystems impacts the hydrological functions of grasslands and associated wetlands. In the coastal tallgrass prairie of Texas, encroachment of woody plants has altered vegetation structure, but the hydrological impacts are poorly understood. In this study, I evaluated and quantified how woody plant encroachment affects hydrological processes on the pimple mounds and inter-mound freshwater marsh, including precipitation partitioning, infiltration in the vadose zone, groundwater recharge, and water volume in the inter-mound marsh. I randomly selected three pimple mounds with woody plants and three pimple mounds with tallgrass w to quantify hydrologic processes. The …

Role Of Acute Alcohol Exposure In Klebsiella Pneumoniae-Induced Pneumonia, Prantho Malakar Dipta

LSU Master's Theses

Klebsiella pneumoniae (KP), a Gram-negative bacterium, induces severe pneumonia associated with devastating pathological consequences in the lung, such as substantial parenchymal damage. K. pneumoniae is responsible for causing life-threatening lung infections in patients with alcoholics and diabetics. The need to look for new therapeutic approaches is due to the emergence of Klebsiella pneumoniae strains that are resistant to many drugs. The effects of acute alcohol consumption on the host’s innate immune response to KP during infection remain unclear. Age-matched C57BL/6 female mice were administered 6g/kg of 32% alcohol or same amount of PBS via oral gavage 30 minutes prior to …

Investigation Of Solvation Structures And Dynamics Of Li-Ion Battery Electrolytes And Amides In Water: An Infrared Spectroscopy, Electrochemical And Computational Study, Ernest O. Nachaki

LSU Doctoral Dissertations

The investigation of solvation structures and dynamics in lithium-ion battery electrolytes and amides in water has significant implications for both fundamental science and practical applications. Understanding the solvation dynamics of lithium electrolytes can lead to the development of safer and more efficient LIBs. The study of hydrogen bond dynamics of N-alkyl substituted amides has important implications for the development of thermos-responsive polymers used in biomedical applications. By understanding how N-alkyl substitutions affect the hydration structure and dynamics of amides, this research can inform the design of polymers with tailored properties for drug delivery, tissue engineering, and other medical applications. This …

Topics In Photonic Quantum Technology: Polarization Entanglement Dynamics In Optical Fibers And Low-Light Imaging., Pratik J. Barge

LSU Doctoral Dissertations

Recent advances in quantum photonics promise transformative impacts on computing, communication, sensing, and imaging. This thesis explores two areas in photonic quantum technology: polarization entanglement dynamics in optical fibers and low-light imaging. Optical fibers are the most suitable medium for photonic qubits and long-distance entanglement distribution is a critical requirement to realize quantum technologies. We study the decay of polarization-entanglement of the Bell state photons propagating through imperfect optical fibers with spatially fluctuating refractive index. Furthermore, to extend the distribution distance, we propose the use of dynamical decoupling in the optical fiber using half waveplates and show that significant improvement …

Riesz Particle Markov Chain Monte Carlo Methods, Xiongming Dai

LSU Doctoral Dissertations

Markov chain Monte Carlo (MCMC) methods are simulations that explore complex statistical distributions, while bypassing the cumbersome requirement of a specific analytical expression for the target. This stochastic exploration of an uncertain parameter space comes at the expense of a large number of ``burn-in'' samples, and the computational complexity leads to the curse of dimensionality. Although at the exploration level, some methods have been proposed to accelerate the convergence of the algorithm, such as tempering, Hamiltonian Monte Carlo, Rao-redwellization, and scalable methods for better performance, they cannot avoid the stochastic nature of this exploration. We develop algorithms for the energy …

Elementary Science Teachers' Experiences: A Case Study On The Use Of Science+Cyber Curriculum, Laurie Salvail

LSU Doctoral Dissertations

The field of science education in the United States has undergone a major reform since 2015. A little more than twelve years ago, work began on constructing a framework for elementary, middle, and high school science education. This framework emphasized the shift from science being merely a memorization of facts to experiences that include science and engineering practices applied through crosscutting concepts and focused on core ideas in the field of science. With new standards teachers also have to overcome a) not having adequate time available to devote to science instruction b) lack of updated instructional materials aligned to the …

Digital Agriculture Applications In Maize Nutrient Management And Soybean Crop Stands Assessment, Bhawana Acharya

LSU Master's Theses

High soil moisture from frequent excessive precipitation can reduce maize (Zea mays L.) yield and increase nitrogen (N) loss. Early-stage soybeans (Glycine max) are also susceptible to damage under these conditions. Traditional methods for assessing N status in maize and plant stands in soybean are labor-intensive and time-consuming. In this study, UAV remote sensing was used to assess maize N status under different N rates and excessive soil moisture. For soybeans, we compared a blob detection method with the YOLOv8 model to estimate plant density using ground images from a handheld camera. Additionally, YOLOv8 performance was evaluated …

Application Of Automated Radio Telemetry To Explore Space Use Of Golden-Cheeked Warblers (Setophaga Chrysoparia), Michael Gamble

LSU Master's Theses

Understanding the spatiotemporal ecology of birds is essential to inform conservation and management decisions that could help maintain bird populations and reverse current population trends. Advancements in automated radio telemetry systems (ARTS) may improve our ability to monitor animal movements continuously and simultaneously but require further testing and development to maximize their benefits for wildlife research. My goals were (1) to investigate the use of automated telemetry to track fine-scale songbird movements in a forested environment, and (2) to use automated telemetry to quantify home range size, spatial overlap between home ranges, and extraterritorial forays for male and female golden-cheeked …

Leveraging The Genomic Tools To Explore The Molecular Basis Of Salinity Tolerance In Rice And Soybean, Rajat Pruthi

LSU Doctoral Dissertations

Salinity stress significantly challenges agricultural productivity, particularly affecting major crops like rice and soybean. This research investigates the genetic basis of salt tolerance in both crops through high-resolution genetic mapping, genome-wide association studies (GWAS), and RNA-Seq analysis. In rice, we examined quantitative trait loci (QTLs) associated with salt tolerance at the seedling and flowering stages using a population of advanced backcrossed introgression lines (ILs). A genetic map, constructed with 14,230 polymorphic SNP markers, identified distinct QTLs and candidate genes for salt tolerance at both stages, suggesting differential genetic controls. Notable genes such as OsHAK13 and OsCYP21-4 were upregulated under salt …

The Role Of Sexual Network Core Groups In Disease Epidemics, Jason Janeaux

LSU Doctoral Dissertations

Sexually transmitted infections (STIs) remain an economic and social burden, non-discriminately affecting sexually active individuals worldwide. The unique transmission of STIs is dependent upon host and pathogen life histories, as well as the underlying network structure of the host population. Within a population there is a group of individuals, the core group, that maintains STI presence and helps sustain ongoing transmission both within the core group and in the surrounding population. While the presence of these core groups is well documented, the criteria for inclusion into a sexual core group is not. In this dissertation, I explore common factors that …