Hyperpolarized Magnetic Resonance Imaging, Nuclear Magnetic Resonance Metabolomics, And Artificial Intelligence To Interrogate The Metabolic Evolution Of Glioblastoma, Kang Lin Hsieh, Qing Chen, Travis C. Salzillo, Jian Zhang, Xiaoqian Jiang, Pratip K. Bhattacharya, Shyan Shams

Faculty Publications

Glioblastoma (GBM) is a malignant Grade VI cancer type with a median survival duration of only 8–16 months. Earlier detection of GBM could enable more effective treatment. Hyperpolarized magnetic resonance spectroscopy (HPMRS) could detect GBM earlier than conventional anatomical MRI in glioblastoma murine models. We further investigated whether artificial intelligence (A.I.) could detect GBM earlier than HPMRS. We developed a deep learning model that combines multiple modalities of cancer data to predict tumor progression, assess treatment effects, and to reconstruct in vivo metabolomic information from ex vivo data. Our model can detect GBM progression two weeks earlier than conventional MRIs …

Empirical Distribution Functions For Farmland Derivative Stocks, Shaharia Jaman Bhuiyan

LSU Master's Theses

Abstract

This thesis investigates the statistical distribution functions fit for modeling the returns of farmland derivative stocks and financial market indexes. Farmland derivative stocks have garnered increased interest due to their potential use in portfolio diversification and risk management. Financial asset returns can be characterized by higher moment behavior in the underlying statistical distribution. This implies that in assessing the statistical distribution properties of risks, proper consideration must be given to the choice of functional form. The Generalized Lambda Distribution (GLD) is used due to its flexibility in model various distribution functions.

The dataset comprises daily and monthly log returns …

Constraining Giant Planet Occurrence Rates With The Multi-Band Imaging Survey For High-Alpha Planets (Mishaps) Observations Of 47 Tucanae, Alison Crisp

LSU Doctoral Dissertations

Though the confirmed exoplanet population has now reached over 5,500 planets, we still have a plethora of unanswered questions, e.g., regarding their formation mechanisms, true demographics, occurrence rates, and habitability. One remaining question is whether hot Jupiters formed in situ or migrated to their current orbits, so close to their host stars that their periods are 10 days or less. This question can potentially be answered by probing the effects of elemental abundances on hot Jupiter occurrence rates. These rates have been found to correlate with metallicity, but the specific elements responsible for the correlation have largely been unresolved. The …

Development Of Satellite-Assisted Forecasting System For Vibrio Vulnificus Prevalence In Coastal Waters, Saber Aradpour

LSU Doctoral Dissertations

Vibrio vulnificus is a halophilic gamma proteobacterium that is autochthonous to coastal waters and is responsible for 50% of seafood-related deaths in the United States. This study presents a series of nowcasting and forecasting models for predicting vibrio vulnificus abundance in oysters by identifying the long-range dependence of vibrio vulnificus abundance on antecedent environmental conditions and detecting the environmental conditions using satellite remote sensing technology. It was discovered that vibrio vulnificus abundance exhibits a long-range dependence on antecedent environmental conditions which can be characterized by seven independent environmental predictors (stressors) including sea surface temperature (SST), water level (WL), sea surface …

A Friendship Of Two Prima Donnas: The Letters Of Adelina Patti To Giulia Valda, Jacquelyn Ancelet

LSU Master's Theses

Of the many prima donnas of the nineteenth century, Adelina Patti (1843–1919) stands out as one of the most successful, with a fifty-year international concertizing career. Biographers across multiple languages have covered her career in great depth, but devote little attention to her close friendships. Herman Klein (in The Reign of Patti [1920]) and John Cone (in Adelina Patti: Queen of Hearts [1993]), for instance, claim that Patti was known by many, but understood by few. One who does seem to have understood her and developed a close relationship with her was Giulia Valda (1850–1925), herself a professional singer, if …

Synthesis Of Portions Of An Acinetobacter Baumannii Lipooligosaccharide (Los), Brandon Conrad

LSU Doctoral Dissertations

Glycoconjugate vaccines have become an effective strategy for protection against an array of globally persistent diseases resulting from pathogenic bacteria such as Haemophilus influenzae type b (Hib), Neisseria meningitidis, and Salmonella enterica serotype Typhi. Comprised of a carbohydrate (referred to as glycan) covalently inked to a carrier protein, these vaccines can initiate adaptive immunity by inducing B and T cell responses once in the lymphatic system. This is particularly relevant for infants two years of age and younger whose immune systems are not fully developed. A continuously emerging threat in clinical settings, Acinetobacter baumannii is a Gram-negative bacterium …

Precision Nutrition For Management Of Cardiovascular Disease Risk During Menopause, Hannah E. Cabre, Emily K. Woolf, Leanne M. Redman

Clinical Research Faculty Publications

Background:Women can spend up to 40%of their lives in the postmenopausal state. As women begin to transition into menopause, known as perimenopause, changes in hormonal concentrations and body composition dramatically increase overall cardiometabolic risk. Dietary patterns and interventions can be utilized to prevent and treat cardiovascular disease (CVD) and some dietary patterns over others may be more beneficial due to their specific effects on the health aspects of menopause. In this narrative review, we summarize key cardiovascular alterations that occur during the menopause transition and explore current dietary recommendations to address CVD risk aswell as explore the newfrontier of precision …

Central Lean Mass Distribution And The Risks Of All-Cause And Cause-Specific Mortality In 40,283 Uk Biobank Participants, Li Ding, Yuxin Fan, Jiaxing Wang, Xiaohui Ma, Lina Chang, Qing He, Gang Hu, Ming Liu

Population and Public Health Science Faculty Publications

Introduction: The purpose of this study was to investigate the association of central lean mass distribution with the risk of mortality. Methods: This cohort study included 40,283 UK Biobank participants. Cox proportional hazards regression models were used to estimate the association of central lean mass distribution, i.e., trunk-to-leg lean mass ratio, assessed by dual-energy X-ray absorptiometry, with the risk of mortality. Results: The median age of the participants was 65 years, and 52% were women. During a median follow-up of 4.18 years, 674 participants died, of whom 366 were due to cancer and 126 were due to cardiovascular causes. Compared …

The Anatomy Of Inequality: Medicine, Mourning, And Socioeconomic Status In Victorian England, Molly G. Decker

LSU Master's Theses

"The Anatomy of Inequality: Medicine, Mourning, and Socioeconomic Status in Victorian England," examines the historic relationships between socioeconomic inequality, death, and medical practice during the Victorian period, with specific ttention on London and surrounding areas. I argue that the extreme socioeconomic disparities of the time were deeply intertwined with the practices surrounding death, mourning, and medical care. The first chapter, "The Price of Sorrow," explores the elaborate mourning rituals and displays of status among the wealthy and upper to middle-class Victorians, detailing how these practices were not only expressions of grief but also conspicuous displays of social status and wealth. …

Ion-Mediated Structural Discontinuities In Phospholipid Vesicles, Judith U. De Mel, Stefanie Klisch, Sudipta Gupta, Gerald J. Schneider

Faculty Publications

Despite intense research, methods for controlling soft matter’s spontaneous self-assembly into well-defined layers remain a significant challenge. We observed ion-induced structural discontinuities of phospholipid vesicles that can be exploited for controlled self-assembly of soft materials, using DOPC and NaCl as a model system. The observations were made for the 0.25 wt % lipid concentration. We used dynamic light scattering, zeta-potential measurement, cryo-electron microscopy, small-angle X-ray, and small-angle neutron scattering to understand the reason for the discontinuities. For salt concentrations below 8 mM, we observed a decrease in the liposome diameter with increased NaCl concentration. Above 8 mM, we measured a …

Susceptibility Of Spodoptera Frugiperda And Helicoverpa Zea Populations In The Southern Region Of The United States To Common Chemical Insecticides, Bhavana Patla

LSU Master's Theses

Abstract

The fall armyworm, Spodoptera frugiperda and corn earworm/bollworm, Helicoverpa zea, are two polyphagous pests prevalent in the U.S. In recent years, there were increased infestations of the two pests in the U.S., especially in its southern region. Information on the susceptibility/resistance status of the two pests in the region to chemical insecticides, especially to some new chemistries, is very limited or has not been updated for many years. In this study, susceptibility of 17 S. frugiperda and six H. zea field collected populations from the southern U.S. during 2021-23 to common insecticides was investigated in the laboratory. Dose-responses with …

Reality Capture Technologies For Continuous Inline Quality Monitoring In Construction 3d Printing, Michael J. Martin Ii

LSU Master's Theses

Extrusion-based construction 3D printing (C3DP) is an innovative and emerging technology aiming at the modernization of the construction industry. It uses robots and computer control to reduce the need for human labor and to decrease construction time and cost. C3DP creates elements layer by layer without using formworks, and it is critical to detect layer defects and deformations to ensure that each layer is printed with the desired dimensions. These defects can lead to a variety of issues during or after the construction process, including the collapse of freshly printed elements. In order to detect such deformations and to enable …

Harmony In Collaboration: Curating Sustainability In Post-Pandemic Arts, Natalie M. Stepaniak

LSU Doctoral Dissertations

In an interconnected world, collaboration in the arts is rising, challenging the traditional notion of the solitary artist. Interdisciplinary collaboration is crucial for advancing performing and visual arts, especially amidst declining audience attendance. Despite the COVID-19 pandemic exacerbating challenges for the arts sector, recent data suggests a gradual recovery, with collaborative efforts fostering resilience.

This dissertation investigates the transformative potential of interdisciplinary collaboration from the perspective of musicians and their organizations. Through three case studies—collaborations between the Rapides Symphony Orchestra and Play On Theater Company, The Next Festival for Emerging Artists, and violist-composer Leilehua Lanzilotti and her collaborative relationship with …

A Confirmatory Factor Analysis Of The Psi-4-Sf In Parents Of Children With Autism Spectrum Disorder, Paige Weir

LSU Doctoral Dissertations

The factor structure of the Parenting Stress Index - Short Form (PSI-4-SF) was evaluated among parents of children with autism spectrum disorder (ASD). Two hypotheses were tested: (1) the original PSI-4-SF model would yield an unsatisfactory fit, and (2) a three-factor alternative model would improve fit compared to the original and other models. A sample of 205 parent-child dyads was analyzed using confirmatory factor analysis (CFA) with the lavaan package in R Studio. Preliminary analyses included descriptive statistics, normality checks, and assessments of skewness and kurtosis. Results supported the first hypothesis, showing poor fit indices for the original PSI-4-SF model. …

Examining Social Anxiety, Generalized Anxiety, And Major Depression’S Symptom Comorbidity In Children And Adolescents: A Longintudinal Test Of The Multiple Pathway Model, Paige Picou

LSU Doctoral Dissertations

Anxiety and depressive disorders are highly prevalent in and impairing for children and adolescents and are highly comorbid. Many theories have been proposed to explain this co- occurrence, with recent models postulating multiple pathways in which specific anxiety disorders and depression may co-occur both concurrently and over time. Unfortunately, little research has evaluated these pathways longitudinally across development in a community sample. The current study tested the multiple pathway model in a sample of 9 to 12-year-old youth (Mage = 9.48, SD= 0.51) at baseline and at two-year follow-up using a subsample of the Adolescent Brain Cognitive Development …

Effects Of Perceived Supervisor And Peer Support On Training Transfer For Frontline Registered Nurses, Carly Penn

LSU Doctoral Dissertations

The purpose of this study was to examine the effect of perceived supervisor support as well as perceived peer support on training transfer behavior outcomes for frontline nursing staff in post-COVID 19 technology-mediated training environments.

This study was guided by the following primary research question: what effect does training delivery, perceived supervisor support, and perceived peer support have on training transfer behavior? The secondary question to further examination of these variables is: How do these factors interact to enhance or inhibit transfer in the context of nurse training?

This study sampled U.S. based registered nurses trained in COVID-19 related protocols. …

Quiet No More: An Analysis Of Women's Protest Music, Jillian Vogel

LSU Doctoral Dissertations

This dissertation explores the multifaceted role of music in women’s protests, emphasizing how it serves as a unifying and rallying tool in the fight against inequality. By delving into the interdisciplinary realms of music theory, sound studies, and women’s and gender studies, this work highlights how women’s protest composers utilize musical texts and content to turn their music into a tool to inspire change. This dissertation investigates the musical structures and harmonic innovations in suffrage movement music, examining how suffragettes with varying musical knowledge engaged with music to further their cause. The suffragette music analyses combine text analysis, harmonic analysis, …

Role Of Acute Alcohol Exposure In Klebsiella Pneumoniae-Induced Pneumonia, Prantho Malakar Dipta

LSU Master's Theses

Klebsiella pneumoniae (KP), a Gram-negative bacterium, induces severe pneumonia associated with devastating pathological consequences in the lung, such as substantial parenchymal damage. K. pneumoniae is responsible for causing life-threatening lung infections in patients with alcoholics and diabetics. The need to look for new therapeutic approaches is due to the emergence of Klebsiella pneumoniae strains that are resistant to many drugs. The effects of acute alcohol consumption on the host’s innate immune response to KP during infection remain unclear. Age-matched C57BL/6 female mice were administered 6g/kg of 32% alcohol or same amount of PBS via oral gavage 30 minutes prior to …

Entanglement From Rotating Black Holes In Thermal Baths, Ivan Agullo, Anthony J. Brady, Adrià Delhom, Dimitrios Kranas

Faculty Publications

We extend previous efforts to quantify the entanglement generated in Hawking's evaporation process by including rotation and thermal environments (e.g. the cosmic microwave background). Both extensions are needed to describe real black holes in our Universe. Leveraging techniques from Gaussian quantum information, we find that the black hole's ergoregion is an active source of quantum entanglement and that thermal environments drastically degrade entanglement generation. Our predictions are suitable to be tested in the lab using analog platforms and also provide tools to assess the fate of quantum information for black holes in more generic settings.

The Impact Of Xenophobia On Agricultural Trade In South Africa, Maxwell Peprah Amponsem

LSU Master's Theses

The growing number of farm attacks and xenophobia is one of the most serious crime issues facing the South African government. This study examines the impact of xenophobia on agricultural trade, using port-level trade data and xenophobia incident records from 2010 to 2023. Utilizing fixed effects Ordinary Least Squares (OLS) specifications, I find a significant negative impact of xenophobia on agricultural exports, while non-agricultural trade remains unaffected. These findings highlight the need for targeted policy interventions to combat xenophobic violence and stabilize the agricultural sector, ensuring the continuity of South Africa's trade and economic growth.

Application Of Automated Radio Telemetry To Explore Space Use Of Golden-Cheeked Warblers (Setophaga Chrysoparia), Michael Gamble

LSU Master's Theses

Understanding the spatiotemporal ecology of birds is essential to inform conservation and management decisions that could help maintain bird populations and reverse current population trends. Advancements in automated radio telemetry systems (ARTS) may improve our ability to monitor animal movements continuously and simultaneously but require further testing and development to maximize their benefits for wildlife research. My goals were (1) to investigate the use of automated telemetry to track fine-scale songbird movements in a forested environment, and (2) to use automated telemetry to quantify home range size, spatial overlap between home ranges, and extraterritorial forays for male and female golden-cheeked …

Elementary Science Teachers' Experiences: A Case Study On The Use Of Science+Cyber Curriculum, Laurie Salvail

LSU Doctoral Dissertations

The field of science education in the United States has undergone a major reform since 2015. A little more than twelve years ago, work began on constructing a framework for elementary, middle, and high school science education. This framework emphasized the shift from science being merely a memorization of facts to experiences that include science and engineering practices applied through crosscutting concepts and focused on core ideas in the field of science. With new standards teachers also have to overcome a) not having adequate time available to devote to science instruction b) lack of updated instructional materials aligned to the …

The Role Of Sexual Network Core Groups In Disease Epidemics, Jason Janeaux

LSU Doctoral Dissertations

Sexually transmitted infections (STIs) remain an economic and social burden, non-discriminately affecting sexually active individuals worldwide. The unique transmission of STIs is dependent upon host and pathogen life histories, as well as the underlying network structure of the host population. Within a population there is a group of individuals, the core group, that maintains STI presence and helps sustain ongoing transmission both within the core group and in the surrounding population. While the presence of these core groups is well documented, the criteria for inclusion into a sexual core group is not. In this dissertation, I explore common factors that …

The Moderating Effect Of Leadership Style On The Relationship Between Perceptions Of Organizational Justice And The Performance Appraisal Satisfaction Of Sport Employees, Jeffrey S. White

LSU Doctoral Dissertations

This dissertation is an examination of how leadership style influences the relationship between sport employee perceptions of organizational justice and their satisfaction with performance appraisals. Sport employees are integral to the sport ecosystem, contributing to the physical, mental, and professional development of athletes, the operational success.

Focusing on these crucial constructs, the purpose of this study is to examine the moderating effect of leadership style on the relationship between organizational justice and performance appraisal satisfaction among sport employees. This quantitative empirical research utilizes PLS-SEM and multiple regression analysis with an aim to confirm the relationship between organizational justice and PAS …

Digital Agriculture Applications In Maize Nutrient Management And Soybean Crop Stands Assessment, Bhawana Acharya

LSU Master's Theses

High soil moisture from frequent excessive precipitation can reduce maize (Zea mays L.) yield and increase nitrogen (N) loss. Early-stage soybeans (Glycine max) are also susceptible to damage under these conditions. Traditional methods for assessing N status in maize and plant stands in soybean are labor-intensive and time-consuming. In this study, UAV remote sensing was used to assess maize N status under different N rates and excessive soil moisture. For soybeans, we compared a blob detection method with the YOLOv8 model to estimate plant density using ground images from a handheld camera. Additionally, YOLOv8 performance was evaluated …

Evaluation Of Dotd’S Aggregate Sources Friction Using Laboratory And Accelerated Testing, Sudhir Bharati

LSU Master's Theses

Roadway safety is of utmost importance to the state transportation agencies. One of the major factors of roadway safety that agencies have control over is pavement friction which is affected by aggregate and mixture type. The Louisiana Department of Transportation and Development (DOTD) currently uses Polished Stone Values (PSV) obtained from the British Pendulum Device to rate its aggregates. These ratings determine the applicability of aggregates for various projects. However, the ratings are inconsistent, posing significant safety and financial risks. The first part of the thesis compares the currently adopted British Wheel Polisher-based Standard Practice for the Accelerated Polishing of …

Towards Addressing Mental Health In Rural Louisiana: Blueberry Supplementation As A Natural Intervention, Katy E. Venable

LSU Doctoral Dissertations

Depression and anxiety are major public health issues; however, there is an unmet need for novel effective and accessible treatments, particularly in rural communities. Blueberries are an unexplored nutraceutical for these conditions due to their excellent nutritional profile, with particularly high levels of polyphenols and anthocyanins and benefits on mood, cognition, and health. Therefore, we conducted a double-blind, randomized pilot study in a rural population. We employed a cross-over design to test the effects of 12 weeks daily ingestion of 24 g of whole freeze-dried blueberry powder versus placebo on symptoms of depression and anxiety in those diagnosed with depression …

Unpacking Influence: Dissecting Engagement Drivers And Dynamics For Effective Influencer Marketing Strategies, Nichole W. Santee

LSU Doctoral Dissertations

Despite influencer marketing's growing significance, brands face challenges in identifying the most effective influencers for their campaigns. This dissertation addresses a gap in influencer marketing engagement literature, focusing on the determinants of consumer engagement in social media interactions.

The impact of specific characteristics found within the proposed influencer marketing sender-receiver communication model on eight behavioral social media engagement metrics is analyzed through a non-traditional content analysis of 218 Instagram influencers utilizing AI analytics platforms. Results reveal several characteristics that significantly affect behavioral engagement, while others have conflicting effects, highlighting the complex nature of the IM industry. Eight hierarchical regressions showed …

Revisionary Taxonomy Within The Acmaeoderini, Joel Dubois

LSU Master's Theses

The jewel beetles (Coleoptera: Buprestidae) are the 8th largest family of beetles and fill various important ecological roles including decomposers, pollinators, and leaf miners. The cosmopolitan buprestid tribe Acmaeoderini is extremely diverse, with more than 700 species across 14 genera. Historically, the acmaederines from Afro-Eurasia have received thorough morphological treatment and nearly all species from these areas have been separated into various genus and subgenus groupings. Contrastingly, past studies in the Americas have been mostly restricted to alpha-level taxonomic descriptions, and only a very small percentage of species are placed into any formal group. The aim of this study was …

An International Multidisciplinary Consensus On Pediatric Metabolic Dysfunction-Associated Fatty Liver Disease, Le Zhang, Mortada El-Shabrawi, Louise A. Baur, Christopher D. Byrne, Giovanni Targher, Mohit Kehar, Gilda Porta, Way Seah Lee, Sander Lefere, Serap Turan, Anna Alisi, Ram Weiss, Maria Felicia Faienza, Ambika Ashraf, Shikha S. Sundaram, Anshu Srivastava, Ruth De Bruyne, Yunkoo Kang, Flora Bacopoulou, Yong Hai Zhou, Andy Darma, Monica Lupsor-Platon, Masahide Hamaguchi, Anoop Misra, Nahum Méndez-Sánchez, Nicholas Beng Hui Ng, Claude Marcus, Amanda E. Staiano, Nadia Waheed, Saleh A. Alqahtani, Cosimo Giannini, Ponsiano Ocama, Mindie H. Nguyen, Maria Teresa Arias-Loste

Population and Public Health Science Faculty Publications

Background: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in children and adolescents, particularly those with obesity. NAFLD is considered a hepatic manifestation of the metabolic syndrome due to its close associations with abdominal obesity, insulin resistance, and atherogenic dyslipidemia. Experts have proposed an alternative terminology, metabolic dysfunction-associated fatty liver disease (MAFLD), to better reflect its pathophysiology. This study aimed to develop consensus statements and recommendations for pediatric MAFLD through collaboration among international experts. Methods: A group of 65 experts from 35 countries and six continents, including pediatricians, hepatologists, and endocrinologists, participated in a consensus development process. The process encompassed …