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Wetland Occupancy By Duck Broods In Cropland-Dominated Landscapes Of The United States Prairie Pothole Region, Blake J. Mitchell, Catrina V. Terry, Kevin M. Ringelman, Kaylan M. Kemink, Michael J. Anteau, Adam K. Janke Feb 2023

Wetland Occupancy By Duck Broods In Cropland-Dominated Landscapes Of The United States Prairie Pothole Region, Blake J. Mitchell, Catrina V. Terry, Kevin M. Ringelman, Kaylan M. Kemink, Michael J. Anteau, Adam K. Janke

Faculty Publications

The Prairie Pothole Region (PPR) is globally important for breeding waterfowl but has been altered via wetland drainage and grassland conversion to accommodate agricultural land use. Thus, understanding the ecology of waterfowl in these highly modified landscapes is essential for their conservation. Brood occurrence is the cumulative outcome of key life-history events including pair formation and territory establishment, nest success, and early brood survival. We applied new technological advances in brood surveying methods to understand brood use of wetlands and how land use and wetland-specific factors influenced brood use of 413 wetlands in crop-dominated landscapes in the PPR of Iowa, …

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Glucagon-Like Peptide-1/Glucagon Receptor Agonism Associates With Reduced Metabolic Adaptation And Higher Fat Oxidation: A Randomized Trial, Karen D. Corbin, Elvis A. Carnero, Timothy D. Allerton, Joachim Tillner, Christopher P. Bock, Pierre Philippe Luyet, Britta Göbel, Kevin D. Hall, Stephanie A. Parsons, Eric Ravussin, Steven R. Smith Feb 2023

Glucagon-Like Peptide-1/Glucagon Receptor Agonism Associates With Reduced Metabolic Adaptation And Higher Fat Oxidation: A Randomized Trial, Karen D. Corbin, Elvis A. Carnero, Timothy D. Allerton, Joachim Tillner, Christopher P. Bock, Pierre Philippe Luyet, Britta Göbel, Kevin D. Hall, Stephanie A. Parsons, Eric Ravussin, Steven R. Smith

Clinical Research Faculty Publications

Objective: This study tested the hypothesis that treatment with the glucagon-like peptide-1/glucagon receptor agonist SAR425899 would lead to a smaller decrease in sleeping metabolic rate (SMR; kilocalories/day) than expected from the loss of lean and fat mass (metabolic adaptation). Methods: This Phase 1b, double-blind, randomized, placebo-controlled study was conducted at two centers in inpatient metabolic wards. Thirty-five healthy males and females with overweight and obesity (age = 36.5 ± 7.1 years) were randomized to a calorie-reduced diet (−1000 kcal/d) and escalating doses (0.06-0.2 mg/d) of SAR425899 (n = 17) or placebo (n = 18) for 19 days. SMR was measured …

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Early Time-Restricted Eating Affects Weight, Metabolic Health, Mood, And Sleep In Adherent Completers: A Secondary Analysis, Felicia L. Steger, Humaira Jamshed, David R. Bryan, Joshua S. Richman, Amy H. Warriner, Cody J. Hanick, Corby K. Martin, Sarah Jeanne Salvy, Courtney M. Peterson Feb 2023

Early Time-Restricted Eating Affects Weight, Metabolic Health, Mood, And Sleep In Adherent Completers: A Secondary Analysis, Felicia L. Steger, Humaira Jamshed, David R. Bryan, Joshua S. Richman, Amy H. Warriner, Cody J. Hanick, Corby K. Martin, Sarah Jeanne Salvy, Courtney M. Peterson

Clinical Research Faculty Publications

Objective: Data are mixed on whether intermittent fasting improves weight loss and cardiometabolic health. Here, the effects of time-restricted eating (TRE) in participants who consistently adhered ≥5 d/wk every week were analyzed. Methods: Ninety patients aged 25 to 75 years old with obesity were randomized to early TRE (eTRE; 8-hour eating window from 07:00 to 15:00) or a control schedule (≥12-hour window) for 14 weeks. A per-protocol analysis of weight loss, body composition, cardiometabolic health, and other end points was performed. Results: Participants who adhered to eTRE ≥5 d/wk every week had greater improvements in body weight (−3.7 ± 1.2 …

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Impact Of Early Time-Restricted Eating On Diet Quality, Meal Frequency, Appetite, And Eating Behaviors: A Randomized Trial, Felicia L. Steger, Humaira Jamshed, Corby K. Martin, Joshua S. Richman, David R. Bryan, Cody J. Hanick, Sarah Jeanne Salvy, Amy H. Warriner, Courtney M. Peterson Feb 2023

Impact Of Early Time-Restricted Eating On Diet Quality, Meal Frequency, Appetite, And Eating Behaviors: A Randomized Trial, Felicia L. Steger, Humaira Jamshed, Corby K. Martin, Joshua S. Richman, David R. Bryan, Cody J. Hanick, Sarah Jeanne Salvy, Amy H. Warriner, Courtney M. Peterson

Clinical Research Faculty Publications

Objective: Time-restricted eating (TRE) can reduce body weight, but it is unclear how it influences dietary patterns and behavior. Therefore, this study assessed the effects of TRE on diet quality, appetite, and several eating behaviors. Methods: Adults with obesity were randomized to early TRE plus energy restriction (eTRE + ER; 8-hour eating window from 7:00 a.m. to 3:00 p.m.) or a control eating schedule plus energy restriction (CON + ER; ≥12-hour window) for 14 weeks. Food intake was assessed via the Remote Food Photography Method, while eating patterns, appetite, and eating behaviors were assessed via questionnaires. Results: A total of …

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Evaluation Of The Peer Leadership For Physical Literacy Intervention: A Cluster Randomized Controlled Trial, Ryan M. Hulteen, David R. Lubans, Ryan E. Rhodes, Guy Faulkner, Yan Liu, Patti Jean Naylor, Nicole Nathan, Katrina J. Waldhauser, Colin M. Wierts, Mark R. Beauchamp Feb 2023

Evaluation Of The Peer Leadership For Physical Literacy Intervention: A Cluster Randomized Controlled Trial, Ryan M. Hulteen, David R. Lubans, Ryan E. Rhodes, Guy Faulkner, Yan Liu, Patti Jean Naylor, Nicole Nathan, Katrina J. Waldhauser, Colin M. Wierts, Mark R. Beauchamp

Faculty Publications

Purpose The purpose of this research was to develop, implement, and test the efficacy of a theory-driven, evidence-informed peer leadership program for elementary school students (Grade 6 and 7; age 11–12 years) and the Grade 3/4 students with whom they were partnered. The primary outcome was teacher ratings of their Grade 6/7 students’ transformational leadership behaviors. Secondary outcomes included: Grade 6/7 students’ leadership self-efficacy, as well as Grade 3/4 motivation, perceived competence, general self-concept, fundamental movement skills, school-day physical activity, and program adherence, and program evaluation. Methods We conducted a two-arm cluster randomized controlled trial. In 2019, 6 schools comprising …

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Framework Of The Alu Subfamily Evolution In The Platyrrhine Three-Family Clade Of Cebidae, Callithrichidae, And Aotidae, Jessica M. Storer, Jerilyn A. Walker, Jasmine N. Baker, Shifat Hossain, Christian Roos, Travis J. Wheeler, Mark A. Batzer Feb 2023

Framework Of The Alu Subfamily Evolution In The Platyrrhine Three-Family Clade Of Cebidae, Callithrichidae, And Aotidae, Jessica M. Storer, Jerilyn A. Walker, Jasmine N. Baker, Shifat Hossain, Christian Roos, Travis J. Wheeler, Mark A. Batzer

Faculty Publications

The history of Alu retroposons has been choreographed by the systematic accumulation of inherited diagnostic nucleotide substitutions to form discrete subfamilies, each having a distinct nucleotide consensus sequence. The oldest subfamily, AluJ, gave rise to AluS after the split between Strepsirrhini and what would become Catarrhini and Platyrrhini. The AluS lineage gave rise to AluY in catarrhines and to AluTa in platyrrhines. Platyrrhine Alu subfamilies Ta7, Ta10, and Ta15 were assigned names based on a standardized nomenclature. However, with the subsequent intensification of whole genome sequencing (WGS), large scale analyses to characterize Alu subfamilies using the program COSEG identified entire …

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The Role Of Nutrition In Mitigating The Effects Of Covid-19 From Infection Through Pasc, Jacob T. Mey, John P. Kirwan, Christopher L. Axelrod Feb 2023

The Role Of Nutrition In Mitigating The Effects Of Covid-19 From Infection Through Pasc, Jacob T. Mey, John P. Kirwan, Christopher L. Axelrod

Division of Basic Science Faculty Publications

The expansive and rapid spread of the SARS-CoV-2 virus has resulted in a global pandemic of COVID-19 infection and disease. Though initially perceived to be acute in nature, many patients report persistent and recurrent symptoms beyond the infectious period. Emerging as a new epidemic, “long-COVID”, or post-acute sequelae of coronavirus disease (PASC), has substantially altered the lives of millions of people globally. Symptoms of both COVID-19 and PASC are individual, but share commonality to established respiratory viruses, which include but are not limited to chest pain, shortness of breath, fatigue, along with adverse metabolic and pulmonary health effects. Nutrition plays …

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Appraisal Of Clinical Care Practices For Child Obesity Treatment. Part I: Interventions, Asheley C. Skinner, Amanda E. Staiano, Sarah C. Armstrong, Shari L. Barkin, Sandra G. Hassink, Jennifer E. Moore, Jennifer S. Savage, Helene Vilme, Ashley E. Weedn, Janice Liebhart, Jeanne Lindros, Eileen M. Reilly Feb 2023

Appraisal Of Clinical Care Practices For Child Obesity Treatment. Part I: Interventions, Asheley C. Skinner, Amanda E. Staiano, Sarah C. Armstrong, Shari L. Barkin, Sandra G. Hassink, Jennifer E. Moore, Jennifer S. Savage, Helene Vilme, Ashley E. Weedn, Janice Liebhart, Jeanne Lindros, Eileen M. Reilly

Population and Public Health Science Faculty Publications

The objective of this technical report is to provide clinicians with evidence-based, actionable information upon which to make assessment and treatment decisions for children and adolescents with obesity. In addition, this report will provide an evidence base to inform clinical practice guidelines for the management and treatment of overweight and obesity in children and adolescents. To this end, the goal of this report was to identify all relevant studies to answer 2 overarching key questions: (KQ1) “What are clinically based, effective treatments for obesity?” and (KQ2) “What is the risk of comorbidities among children with obesity?” See Appendix 1 for …

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Appraisal Of Clinical Care Practices For Child Obesity Treatment. Part Ii: Comorbidities, Asheley C. Skinner, Amanda E. Staiano, Sarah C. Armstrong, Shari L. Barkin, Sandra G. Hassink, Jennifer E. Moore, Jennifer S. Savage, Helene Vilme, Ashley E. Weedn, Janice Liebhart, Jeanne Lindros, Eileen M. Reilly Feb 2023

Appraisal Of Clinical Care Practices For Child Obesity Treatment. Part Ii: Comorbidities, Asheley C. Skinner, Amanda E. Staiano, Sarah C. Armstrong, Shari L. Barkin, Sandra G. Hassink, Jennifer E. Moore, Jennifer S. Savage, Helene Vilme, Ashley E. Weedn, Janice Liebhart, Jeanne Lindros, Eileen M. Reilly

Population and Public Health Science Faculty Publications

The objective of this technical report is to provide clinicians with actionable evidence-based information upon which to make treatment decisions. In addition, this report will provide an evidence base on which to inform clinical practice guidelines for the management and treatment of overweight and obesity in children and adolescents. To this end, the goal of this report was to identify all relevant studies to answer 2 overarching key questions: (KQ1) “What are effective clinically based treatments for obesity?” and (KQ2) “What is the risk of comorbidities among children with obesity?” See Appendix 1 for the conceptual framework and a priori …

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Envirome-Wide Associations Enhance Multi-Year Genome-Based Prediction Of Historical Wheat Breeding Data, Germano Costa-Neto, Leonardo Crespo-Herrera, Nick Fradgley, Keith Gardner, Alison R. Bentley, Susanne Dreisigacker, Roberto Fritsche-Neto, Osval A. Montesinos-López, Jose Crossa Feb 2023

Envirome-Wide Associations Enhance Multi-Year Genome-Based Prediction Of Historical Wheat Breeding Data, Germano Costa-Neto, Leonardo Crespo-Herrera, Nick Fradgley, Keith Gardner, Alison R. Bentley, Susanne Dreisigacker, Roberto Fritsche-Neto, Osval A. Montesinos-López, Jose Crossa

Faculty Publications

Linking high-throughput environmental data (enviromics) to genomic prediction (GP) is a cost-effective strategy for increasing selection intensity under genotype-by-environment interactions (G × E). This study developed a data-driven approach based on Environment–Phenotype Association (EPA) aimed at recycling important G × E information from historical breeding data. EPA was developed in two applications: (1) scanning a secondary source of genetic variation, weighted from the shared reaction-norms of past-evaluated genotypes and (2) pinpointing weights of the similarity among trial-sites (locations), given the historical impact of each envirotyping data variable for a given site. These results were then used as a dimensionality reduction …

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Discovery Of Novel Bioactive Tanshinones And Carnosol Analogues Against Breast Cancer, Miguel A. González-Cardenete, Natalia González-Zapata, Lucinda Boyd, Fatima Rivas Feb 2023

Discovery Of Novel Bioactive Tanshinones And Carnosol Analogues Against Breast Cancer, Miguel A. González-Cardenete, Natalia González-Zapata, Lucinda Boyd, Fatima Rivas

Faculty Publications

The abietane diterpenoids ferruginol (1), tanshinone IIA (3), and carnosol (4) are well-known for their interesting pharmacological properties, including antitumor, similar to other natural and semisynthetic abietanes. In this study, a pair of semisynthetic C18-functionalized analogues of 3 and 4 were prepared from the commercially available (+)-dehydroabietylamine or readily obtained methyl dehydroabietate. Semisynthetic ferruginol (1) and some selected analogues, together with the synthesized analogues, were tested in vitro for the inhibition of proliferation in four breast cancer cell lines, SUM149, MDA-MB231, T47D, and MCF07. As a result, several tested abietane analogues decreased cell proliferation and enhanced cell death, with IC50 …

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Total Utilization-Upcycling Of Mushroom Protein By-Product: Characterization And Assessment As An Alternative Batter Ingredient For Fried Shrimp, Diego Garcia, Seung Woon You, Ricardo S. Aleman, Joan M. King, Slavko Komarnytsky, Roberta Targino Hoskin, Marvin Moncada Feb 2023

Total Utilization-Upcycling Of Mushroom Protein By-Product: Characterization And Assessment As An Alternative Batter Ingredient For Fried Shrimp, Diego Garcia, Seung Woon You, Ricardo S. Aleman, Joan M. King, Slavko Komarnytsky, Roberta Targino Hoskin, Marvin Moncada

Faculty Publications

Mushroom by-products are economical and eco-friendly raw materials with bioactive and functional characteristics that allow for potential uses as food ingredients. However, mushroom upcycling has yet to be fully exploited, despite the many opportunities that mushrooms may offer. The mushroom protein by-product (MPBP) resulting from mushroom protein production was characterized (chemical composition, physicochemical attributes, and functional properties) and incorporated into plant-based batter formulations to prepare four experimental groups with different ratios (w/w, %) of wheat flour (W) to MPBP (100 W, 75 W/25 MPBP, 25 W/75 MPBP, and 100 MPBP). Subsequently, the batter was used for frying batter-coated shrimp, which …

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The Effect Of Watermelon Juice Supplementation On Heart Rate Variability And Metabolic Response During An Oral Glucose Challenge: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial, Rachel Matthews, Kate S. Early, Cullen M. Vincellette, Jack Losso, Guillaume Spielmann, Brian A. Irving, Timothy D. Allerton Feb 2023

The Effect Of Watermelon Juice Supplementation On Heart Rate Variability And Metabolic Response During An Oral Glucose Challenge: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial, Rachel Matthews, Kate S. Early, Cullen M. Vincellette, Jack Losso, Guillaume Spielmann, Brian A. Irving, Timothy D. Allerton

Faculty Publications

Heart rate variability (HRV) provides a simple method to evaluate autonomic function in health and disease. A reduction in HRV may indicate autonomic dysfunction and is strongly associated with aspects of cardiometabolic disease, including hyperglycemia. Reduced nitric oxide (NO) bioavailability is also implicated in the development of cardiometabolic disease and autonomic dysfunction. Watermelons are natural sources of L-arginine and L-citrulline, substrates used for NO synthesis. Watermelon consumption can improve NO bioavailability. We conducted a randomized, double-blind, placebo-controlled crossover trial to test the effects of 2 weeks of daily watermelon juice (WMJ) supplementation on HRV in response to an oral glucose …

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Classification Analysis Of Southwest Pacific Tropical Cyclone Intensity Changes Prior To Landfall, Rupsa Bhowmick, Jill C. Trepanier, Alex M. Haberlie Feb 2023

Classification Analysis Of Southwest Pacific Tropical Cyclone Intensity Changes Prior To Landfall, Rupsa Bhowmick, Jill C. Trepanier, Alex M. Haberlie

Faculty Publications

This study evaluates the ability of a random forest classifier to identify tropical cyclone (TC) intensification or weakening prior to landfall over the western region of the Southwest Pacific Ocean (SWPO) basin. For both Australia mainland and SWPO island cases, when a TC first crosses land after spending ≥24 h over the ocean, the closest hour prior to the intersection is considered as the landfall hour. If the maximum wind speed (Vmax) at the landfall hour increased or remained the same from the 24-h mark prior to landfall, the TC is labeled as intensifying and if the Vmax at the …

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Clues From The Paint A Picture Of Earth’S Water Cycle, Kristine L. Delong, Alyssa Atwood, Andrea Moore, Sara Sanchez Feb 2023

Clues From The Paint A Picture Of Earth’S Water Cycle, Kristine L. Delong, Alyssa Atwood, Andrea Moore, Sara Sanchez

Faculty Publications

No abstract provided.

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Editorial Introduction: Contributing To The Policy Process Literatures, Geoboo Song, Michael D. Jones, Melissa K. Merry, Holly L. Peterson, Aaron Smith-Walter, Gwen Arnold, Rachael Moyer, Creed Tumlison Feb 2023

Editorial Introduction: Contributing To The Policy Process Literatures, Geoboo Song, Michael D. Jones, Melissa K. Merry, Holly L. Peterson, Aaron Smith-Walter, Gwen Arnold, Rachael Moyer, Creed Tumlison

Faculty Publications

No abstract provided.

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Neutron Imaging Of Al6061 Prepared By Solid-State Friction Stir Additive Manufacturing, Saber Nemati, Leslie G. Butler, Kyungmin Ham, Gerald L. Knapp, Congyuan Zeng, Selami Emanet, Hamed Ghadimi, Shengmin Guo, Yuxuan Zhang, Hassina Bilheux Feb 2023

Neutron Imaging Of Al6061 Prepared By Solid-State Friction Stir Additive Manufacturing, Saber Nemati, Leslie G. Butler, Kyungmin Ham, Gerald L. Knapp, Congyuan Zeng, Selami Emanet, Hamed Ghadimi, Shengmin Guo, Yuxuan Zhang, Hassina Bilheux

Faculty Publications

Solid-state Friction Stir Additive Manufacturing has recently gained attention as a result of its capacity to fabricate large-scale parts while preserving the mechanical properties of the feedstock material. However, the correlation between the quality of layer-by-layer bonding of the deposited metal and processing parameters has remained unknown. Neutron imaging techniques, with 90% total transmission per cm, are employed for Al6061 parts fabricated by MELD® Technology as a non-destructive evaluation approach for the first time to investigate the layer-by-layer structure of a stadium-shaped ingot in different sections. The post-processed results show the fabricated parts with an optimized set of processing parameters …

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Hardness Distribution Of Al2050 Parts Fabricated Using Additive Friction Stir Deposition, Hamed Ghadimi, Huan Ding, Selami Emanet, Mojtaba Talachian, Chase Cox, Michael Eller, Shengmin Guo Feb 2023

Hardness Distribution Of Al2050 Parts Fabricated Using Additive Friction Stir Deposition, Hamed Ghadimi, Huan Ding, Selami Emanet, Mojtaba Talachian, Chase Cox, Michael Eller, Shengmin Guo

Faculty Publications

The solid-state additive friction stir deposition (AFSD) process is a layer-by-layer metal 3D-printing technology. In this study, AFSD is used to fabricate Al–Cu–Li 2050 alloy parts. The hardness values for various regions of the as-deposited built parts are measured, and the results are contrasted with those of the feedstock material. The as-fabricated Al2050 parts are found to have a unique hardness distribution due to the location-specific variations in the processing temperature profile. The XRD results indicate the presence of the secondary phases in the deposited parts, and EDS mapping confirms the formation of detectable alloying particles in the as-deposited Al2050 …

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Wind Loads On Overhead Sign Structures: A Comparative Study, Aly Mousaad Aly, James Benson Feb 2023

Wind Loads On Overhead Sign Structures: A Comparative Study, Aly Mousaad Aly, James Benson

Faculty Publications

Road signs are prone to extreme winds that cause significant damage. Overhead sign structures can disrupt traffic and cause harm to the traveling public if a failure occurs under extreme wind conditions. In this paper, we employ Computational Fluid Dynamics (CFD) in a comparative study to understand the aerodynamics of standard, porous, and curved signs. The study shows the viability of porous and curved overhead boards for lessening aerodynamic loads, which can mini-mize damage and enhance safety on roadways. Porous overhead signs can decrease the drag forces; however, the size of the openings is a vital parameter in reducing wind …

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A Simple Micromilled Microfluidic Impedance Cytometer With Vertical Parallel Electrodes For Cell Viability Analysis, Jason Eades, Julianne F. Audiffred, Micah Fincher, Jin Woo Choi, Steven A. Soper, William Todd Monroe Feb 2023

A Simple Micromilled Microfluidic Impedance Cytometer With Vertical Parallel Electrodes For Cell Viability Analysis, Jason Eades, Julianne F. Audiffred, Micah Fincher, Jin Woo Choi, Steven A. Soper, William Todd Monroe

Faculty Publications

Microfluidic impedance cytometry has been demonstrated as an effective platform for single cell analysis, taking advantage of microfabricated features and dielectric cell sensing methods. In this study, we present a simple microfluidic device to improve the sensitivity, accuracy, and throughput of single suspension cell viability analysis using vertical sidewall electrodes fabricated by a widely accessible negative manufacturing method. A microchannel milled through a 75 µm platinum wire, which was embedded into poly-methyl-methacrylate (PMMA), created a pair of parallel vertical sidewall platinum electrodes. Jurkat cells were interrogated in a custom low-conductivity buffer (1.2 ± 0.04 mS/cm) to reduce current leakage and …

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Editorial: Emerging Research Organisms In Regenerative Biology, Stefano Tiozzo, Igor Schneider Jan 2023

Editorial: Emerging Research Organisms In Regenerative Biology, Stefano Tiozzo, Igor Schneider

Faculty Publications

No abstract provided.

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Non-Equilibrium Colloidal Phenomena In Magnetic Fields And Photoillumination: From Controlling Living Microbots To Understanding Microplastics, Ahmed Al Harraq Jan 2023

Non-Equilibrium Colloidal Phenomena In Magnetic Fields And Photoillumination: From Controlling Living Microbots To Understanding Microplastics, Ahmed Al Harraq

LSU Doctoral Dissertations

Colloids are a ubiquitous class of materials composed of microscopic particles suspended in a continuous phase which are found in everyday products and in nature. Colloids are also useful models for studying the spontaneous arrangement of matter from individual building blocks to mesophases. Standard treatment of colloid science is based on the assumption of equilibrium conditions, as defined in traditional thermodynamics. However, novel assembly mechanisms and motility are unlocked by pushing colloids away from equilibrium using external energy. In addition, many colloids in nature and in industrial applications exchange energy and mass with the surrounding environment thus behaving in a …

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Sediment Transport And Geomorphological Evolution In The Northern Gulf Of Mexico, Kelli Moran Jan 2023

Sediment Transport And Geomorphological Evolution In The Northern Gulf Of Mexico, Kelli Moran

LSU Doctoral Dissertations

This dissertation explores the mechanisms driving sediment transport and deposition on the continental shelf and within the bays of the northern Gulf of Mexico via a suite of geophysical methods and sediment cores on a variety of timescales. This dissertation is comprised of three main chapters, each focusing on a different location, environment, and process but tied together using geophysical survey, a thematic focus on geomorphic change and sediment transport within the deltaic cycle and deltaic plain environments, and the implications this change poses for both past and future sediment transport and environmental change in response to sea level change. …

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An Exploration Of Black Women Faculty Members' Faculty Development And Career Advancement Experiences Within A Pwi, Monica N. Guient Jan 2023

An Exploration Of Black Women Faculty Members' Faculty Development And Career Advancement Experiences Within A Pwi, Monica N. Guient

LSU Doctoral Dissertations

At a large, research-intensive, predominantly White university, in this qualitative case study, Black women faculty members’ experiences with and perceptions of institutionally sponsored faculty development activities in relation to career advancement was explored. The career advancement of faculty members from underrepresented and minoritized populations—particularly Black women—is ultimately impacted by the racialized and gendered disparities among tenure-track and tenured professors in research, service, and teaching. Unique to this study is the exploration of how Black women faculty members experience the human resource development practice of faculty development while also gathering information from the institutional leaders who oversee and guide institutionally sponsored …

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Controls Of Physical Drivers On The Formation And Toxicity Of Harmful Cyanobacteria Blooms (Cyanohabs), Courtney N. Hammond Jan 2023

Controls Of Physical Drivers On The Formation And Toxicity Of Harmful Cyanobacteria Blooms (Cyanohabs), Courtney N. Hammond

LSU Master's Theses

Estuaries within the Gulf of Mexico are exhibiting profound alterations due to climatic changes and the implementation of coastal restoration activities. These changes are attributed to the increasing frequency of harmful cyanobacteria blooms (cyanoHABs) within Lake Pontchartrain, an estuary located in southeastern Louisiana, USA. There is a better understanding into how the opening of the Bonnet Carré Spillway (BCS) impacts cyanoHAB formations compared to the effect of other physical drivers when the spillway doesn’t dominate the system. The goal of this study is to provide a greater understanding of the baseline conditions when the BCS is closed and determine what …

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Chiral Uncertainties In Ab Initio Elastic Nucleon-Nucleus Scattering, Robert B. Baker, Matthew Burrows, Charlotte Elster, Kristina D. Launey, Pieter Maris, Gabriela Popa, Stephen P. Weppner Jan 2023

Chiral Uncertainties In Ab Initio Elastic Nucleon-Nucleus Scattering, Robert B. Baker, Matthew Burrows, Charlotte Elster, Kristina D. Launey, Pieter Maris, Gabriela Popa, Stephen P. Weppner

Faculty Publications

The effective interaction between a nucleon and a nucleus is one of the most important ingredients for reaction theories. Theoretical formulations were introduced early by Feshbach and Watson, and efforts of deriving and computing those ‘optical potentials’ in a microscopic fashion have a long tradition. However, only recently the leading order term in the Watson multiple scattering approach could be calculated fully ab initio, meaning that the same nucleon-nucleon (NN) interaction enters both the structure as well as the reaction pieces on equal footing. This allows the uncertainties from the underlying chiral effective NN interaction to be systematically explored in …

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Development Of A Peptide-Based Protac Incorporating A Β-Hairpin Sequence, Hannah Catherine Hymel Jan 2023

Development Of A Peptide-Based Protac Incorporating A Β-Hairpin Sequence, Hannah Catherine Hymel

LSU Doctoral Dissertations

The ubiquitin-proteasome system (UPS) is a biochemical pathway primarily responsible for the degradation of damaged proteins. The UPS is regulated by E3 ubiquitin ligases, which recognize specific degradation sequences, or degrons, on a protein leading to protein ubiquitination and subsequent degradation by the proteasome. Proteolysis targeting chimeras (PROTACs) have emerged as a novel therapeutic agent to selectively degrade ‘undruggable’ targets; however, many peptide-based PROTACs suffer low cell permeability and high protease susceptibility. The goal of this work is to utilize degron-based substrates that function as cell penetrating peptides (CPPs) in a PROTAC to selectively degrade a target. The first part …

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Microplastics In Mainstem Mississippi River Fishes, Ahmed K. Gad, Kerrin Toner, Mark C. Benfield, Stephen R. Midway Jan 2023

Microplastics In Mainstem Mississippi River Fishes, Ahmed K. Gad, Kerrin Toner, Mark C. Benfield, Stephen R. Midway

Faculty Publications

Microplastics are ubiquitous in Earth’s ecosystems and many efforts have begun to understand their distributions. Large rivers, like the Mississippi River, provide a unique system in which to look at large-scale patterns of microplastic distribution. In this study, we sampled four species of widely-distributed fishes from five sites along the mainstem Mississippi River, from Minnesota to Louisiana, United States. Microplastics were found in all fish species and at all sites; however, microplastics increased in occurrence in the Lower Mississippi River. Fragments were the most common morphologies and polypropylene was the most common polymer detected. We also examined the hypothesis that …

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Editorial: Abiotic Stress: Molecular Genetics And Genomics, Volume Ii, Rohini Garg, Prasanta K. Subudhi, Rajeev K. Varshney, Mukesh Jain Jan 2023

Editorial: Abiotic Stress: Molecular Genetics And Genomics, Volume Ii, Rohini Garg, Prasanta K. Subudhi, Rajeev K. Varshney, Mukesh Jain

Faculty Publications

No abstract provided.

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Dual Targeting Of Mtor/Il-17a And Autophagy By Fisetin Alleviates Psoriasis-Like Skin Inflammation, Tithi Roy, Sergette Banang-Mbeumi, Samuel T. Boateng, Emmanuelle M. Ruiz, Roxane Cherille N. Chamcheu, Lin Kang, Judy A. King, Anthony L. Walker, Bolni Marius Nagalo, Konstantin G. Kousoulas, Stephane Esnault, Shile Huang, Jean Christopher Chamcheu Jan 2023

Dual Targeting Of Mtor/Il-17a And Autophagy By Fisetin Alleviates Psoriasis-Like Skin Inflammation, Tithi Roy, Sergette Banang-Mbeumi, Samuel T. Boateng, Emmanuelle M. Ruiz, Roxane Cherille N. Chamcheu, Lin Kang, Judy A. King, Anthony L. Walker, Bolni Marius Nagalo, Konstantin G. Kousoulas, Stephane Esnault, Shile Huang, Jean Christopher Chamcheu

Faculty Publications

Psoriasis is a chronic autoimmune inflammatory skin disorder characterized by epidermal hyperplasia and aberrant immune response. In addition to aberrant cytokine production, psoriasis is associated with activation of the Akt/mTOR pathway. mTOR/S6K1 regulates T-lymphocyte activation and migration, keratinocytes proliferation and is upregulated in psoriatic lesions. Several drugs that target Th1/Th17 cytokines or their receptors have been approved for treating psoriasis in humans with variable results necessitating improved therapies. Fisetin, a natural dietary polyphenol with anti-oxidant and anti-proliferative properties, covalently binds mTOR/S6K1. The effects of fisetin on psoriasis and its underlying mechanisms have not been clearly defined. Here, we evaluated the …

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