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Maternal Insulin Resistance And Maternal Β-Cell Function During Pregnancy For Offspring Overweight Before 2 Years Of Age Among Women With Gestational Diabetes, Ming Gao, Hui Wang, Weiqin Li, Leishen Wang, Ninghua Li, Yijuan Qiao, Tao Zhang, Jing Li, Zhijie Yu, Gang Hu, Junhong Leng, Xilin Yang Mar 2023

Maternal Insulin Resistance And Maternal Β-Cell Function During Pregnancy For Offspring Overweight Before 2 Years Of Age Among Women With Gestational Diabetes, Ming Gao, Hui Wang, Weiqin Li, Leishen Wang, Ninghua Li, Yijuan Qiao, Tao Zhang, Jing Li, Zhijie Yu, Gang Hu, Junhong Leng, Xilin Yang

Population and Public Health Science Faculty Publications

Objective: To explore associations of maternal insulin resistance and β-cell dysfunction with offspring overweight before 24 months of age among children of Chinese women with gestational diabetes mellitus (GDM). Methods: Offspring of women with GDM (n = 901) who were enrolled in a lifestyle trial during pregnancy were followed up to 24 months of age in Tianjin, China. Restricted cubic spline analysis was performed to examine full-range associations of maternal homeostatic model assessment of insulin resistance (HOMA-IR) and β-cell function (HOMA-%β) with childhood overweight. Logistic regression was performed to obtain the odds ratios (ORs) and 95% confidence interval (CI) of …

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The Interaction Of Rurality And Rare Cancers For Travel Time To Cancer Care, Tracy Onega, Jennifer Alford-Teaster, Chris Leggett, Andrew Loehrer, Julie E. Weiss, Erika L. Moen, Catherine C. Pollack, Fahui Wang Mar 2023

The Interaction Of Rurality And Rare Cancers For Travel Time To Cancer Care, Tracy Onega, Jennifer Alford-Teaster, Chris Leggett, Andrew Loehrer, Julie E. Weiss, Erika L. Moen, Catherine C. Pollack, Fahui Wang

Faculty Publications

Purpose: Geographic access to cancer care is known to significantly impact utilization and outcomes. Longer travel times have negative impacts for patients requiring highly specialized care, such as for rare cancers, and for those in rural areas. Scant population-based research informs geographic access to care for rare cancers and whether rurality impacts that access. Methods: Using Medicare data (2014-2015), we identified prevalent cancers and cancer-directed surgeries, chemotherapy, and radiation. We classified cancers as rare (incidence <6/100,000/year) or common (incidence ≥6/100,000/year) using previously published thresholds and categorized rurality from ZIP code of beneficiary residence. We estimated travel time between beneficiaries and providers for each service based on ZIP code. Descriptive statistics summarized travel time by rare versus common cancers, service type, and rurality. Findings: We included 1,169,761 Medicare beneficiaries (21.9% in nonmetropolitan areas), 87,399; 7.5% had rare cancers, with 9,133,003 cancer-directed services. Travel times for cancer services ranged from approximately 29 minutes (25th percentile) to 68 minutes (75th percentile). Travel times were similar for rare and common cancers overall (median: 45 vs 43 minutes) but differed by service type; 13.4% of surgeries were >2 hours away for rare cancers, compared to 8.3% for common cancers. Increasing rurality disproportionately increased travel time to surgical care for rare compared to …

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Atmospheric Density Inversion Based On Swarm-C Satellite Accelerometer, Lirong Yin, Lei Wang, Jiawei Tian, Zhengtong Yin, Mingzhe Liu, Wenfeng Zheng Mar 2023

Atmospheric Density Inversion Based On Swarm-C Satellite Accelerometer, Lirong Yin, Lei Wang, Jiawei Tian, Zhengtong Yin, Mingzhe Liu, Wenfeng Zheng

Faculty Publications

We used the Swarm-C accelerometer data to invert the orbital atmospheric density in this study. First, the Swarm-C satellite mission data were obtained from the ESA’s public data platform, and preliminary data error correction was performed. This paper refers to the calibration method of GRACE-A satellite accelerometer data. It adds linear temperature correction on the original basis. Moreover, this study’s accelerometer data correction results were compared with the data correction results published by the ESA. In order to explore the influence of light radiation on the accelerometer, we established a geometric model of Swarm-C to simulate the physical shape of …

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On The Effect Of Environmental Temperature On Fracture Fatigue Entropy, Mohammad A. Amooie, M. M. Khonsari Mar 2023

On The Effect Of Environmental Temperature On Fracture Fatigue Entropy, Mohammad A. Amooie, M. M. Khonsari

Faculty Publications

Fracture behavior of carbon steel 1018 operating in low-temperature environments is investigated. Specifically, fully-reversed bending experimental tests are performed to examine the efficacy of applying the concept of Fracture Fatigue Entropy (FFE) for predicting fatigue life at different environmental temperatures. A large cooling chamber was constructed that houses the entire bending test rig and maintains the environmental temperature at the desired value down to −10 °C. It is shown that under conditions tested, fatigue life improves at lower operating temperatures. Results also reveal that FFE remains nearly constant and can be used for reliable prediction of fatigue life. Illustrative examples …

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Florawear: Wearable Living Interface, Hye Yeon Nam, Janiece Campbell, Andrew M. Webb, Brendan Harmon Feb 2023

Florawear: Wearable Living Interface, Hye Yeon Nam, Janiece Campbell, Andrew M. Webb, Brendan Harmon

Faculty Publications

While nature can benefit people both mentally and physically, contemporary society has become increasingly disconnected from nature. To rebuild a stronger connection with nature in our everyday life, we introduce FloraWear, a do-it-yourself, wearable living interface, that enables people to easily and closely connect with plants. This pictorial introduces how knowledge is built and shared with others using hybrid craft and fabrication, illustrates the material experiments and design development for FloraWear, and discusses how it affects wearers. Then we summarize how FloraWear can help catalyze a shift in people's perspectives towards nature. By developing emotional ties to their wearable plants, …

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Asprosin Promotes Feeding Through Sk Channel-Dependent Activation Of Agrp Neurons, Bing Feng, Hesong Liu, Ila Mishra, Clemens Duerrschmid, Peiyu Gao, Pingwen Xu, Chunmei Wang, Yanlin He Feb 2023

Asprosin Promotes Feeding Through Sk Channel-Dependent Activation Of Agrp Neurons, Bing Feng, Hesong Liu, Ila Mishra, Clemens Duerrschmid, Peiyu Gao, Pingwen Xu, Chunmei Wang, Yanlin He

Division of Basic Science Faculty Publications

Asprosin, a recently identified adipokine, activates agouti-related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus (ARH) via binding to protein tyrosine phosphatase receptor δ (Ptprd) to increase food intake. However, the intracellular mechanisms responsible for asprosin/Ptprd-mediated activation of AgRPARH neurons remain unknown. Here, we demonstrate that the small-conductance calcium-activated potassium (SK) channel is required for the stimulatory effects of asprosin/Ptprd on AgRPARH neurons. Specifically, we found that deficiency or elevation of circulating asprosin increased or decreased the SK current in AgRPARH neurons, respectively. AgRPARH-specific deletion of SK3 (an SK channel subtype highly expressed in AgRPARH neurons) blocked asprosin-induced …

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Association Of Metformin With The Development Of Age-Related Macular Degeneration, Amitha Domalpally, Samuel A. Whittier, Qing Pan, Dana M. Dabelea, Christine H. Darwin, William C. Knowler, Christine G. Lee, Jose A. Luchsinger, Neil H. White, Emily Y. Chew, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. Smith, Lisa L. Smith, Julia A.St Amant Feb 2023

Association Of Metformin With The Development Of Age-Related Macular Degeneration, Amitha Domalpally, Samuel A. Whittier, Qing Pan, Dana M. Dabelea, Christine H. Darwin, William C. Knowler, Christine G. Lee, Jose A. Luchsinger, Neil H. White, Emily Y. Chew, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. Smith, Lisa L. Smith, Julia A.St Amant

Population and Public Health Science Faculty Publications

Importance: Age-related macular degeneration (AMD) is a leading cause of blindness with no treatment available for early stages. Retrospective studies have shown an association between metformin and reduced risk of AMD. Objective: To investigate the association between metformin use and age-related macular degeneration (AMD). Design, Setting, and Participants: The Diabetes Prevention Program Outcomes Study is a cross-sectional follow-up phase of a large multicenter randomized clinical trial, Diabetes Prevention Program (1996-2001), to investigate the association of treatment with metformin or an intensive lifestyle modification vs placebo with preventing the onset of type 2 diabetes in a population at high risk for …

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Enhanced Phase Sensitivity In A Mach-Zehnder Interferometer Via Photon Recycling, Dong Li, Chun Hua Yuan, Xiaoping Ma, Qingle Wang, Hwang Lee, Yao Yao, Weiping Zhang Feb 2023

Enhanced Phase Sensitivity In A Mach-Zehnder Interferometer Via Photon Recycling, Dong Li, Chun Hua Yuan, Xiaoping Ma, Qingle Wang, Hwang Lee, Yao Yao, Weiping Zhang

Faculty Publications

We propose an alternative scheme for phase estimation in a Mach-Zehnder interferometer (MZI) with photon recycling. It is demonstrated that with the same coherent-state input and homodyne detection, our proposal possesses a phase sensitivity beyond the traditional MZI. For instance, it can achieve an enhancement factor of ∼9.32 in the phase sensitivity compared with the conventional scheme even with a photon loss of 10% on the photon-recycled arm. From another point of view, the quantum Cramér-Rao bound (QCRB) is also investigated. It is found that our scheme is able to achieve a lower QCRB than the traditional one. Intriguingly, the …

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Atomistic Simulation Studies Of Thin Film Growth And Plastic Deformation In Metals And Metal/Ceramic Nanostructures, Reza Namakian Feb 2023

Atomistic Simulation Studies Of Thin Film Growth And Plastic Deformation In Metals And Metal/Ceramic Nanostructures, Reza Namakian

LSU Doctoral Dissertations

Despite the significant improvements in manufacturing and synthesis processes of metals and ceramics in the past decades, there are still areas in which the procedure is still frequently more of an art or skill rather than a science. Therefore, systematic and combined experimental and computational studies are required to facilitate the development of techniques that offer thorough understanding of the events taking place during manufacturing and synthesis processes. With regard to these issues, it is paramount to address microscale characterizations and atomic scale understanding of the events during fabrication processes. One of the focuses of this study is unraveling fundamental …

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Editorial: Community Series In Research Efforts, Challenges And Opportunities In Mitigating Aflatoxins In Food And Agricultural Crops And Its Global Health Impacts, Volume Ii, Mehdi Razzaghi-Abyaneh, Zhi Yuan Chen, Mahendra Rai, Masoomeh Shams-Ghahfarokhi Feb 2023

Editorial: Community Series In Research Efforts, Challenges And Opportunities In Mitigating Aflatoxins In Food And Agricultural Crops And Its Global Health Impacts, Volume Ii, Mehdi Razzaghi-Abyaneh, Zhi Yuan Chen, Mahendra Rai, Masoomeh Shams-Ghahfarokhi

Faculty Publications

No abstract provided.

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Gamerfit-Asd Beta Test: Adapting An Evidence-Based Exergaming And Telehealth Coaching Intervention For Autistic Youth, Daniel P. Hatfield, Aviva Must, Winston Kennedy, Amanda E. Staiano, James Slavet, Rachael A. Sabelli, Carol Curtin, Linda G. Bandini, Phillip Nauta, Christopher Stuetzle, April B. Bowling Feb 2023

Gamerfit-Asd Beta Test: Adapting An Evidence-Based Exergaming And Telehealth Coaching Intervention For Autistic Youth, Daniel P. Hatfield, Aviva Must, Winston Kennedy, Amanda E. Staiano, James Slavet, Rachael A. Sabelli, Carol Curtin, Linda G. Bandini, Phillip Nauta, Christopher Stuetzle, April B. Bowling

Population and Public Health Science Faculty Publications

Background: Health disparities faced by autistic youth are exacerbated by inadequate physical activity (PA) and sleep, whereas healthy PA and sleep may improve mood and function. Adaptive Game Squad (AGS) is an evidence-based telehealth coaching and exergaming intervention to improve PA and sleep for adolescents with diverse neurodevelopmental and psychiatric conditions. This study aimed to adapt AGS for autistic youth ages 10–15 years; beta-test the modified intervention for feasibility, accessibility, and engagement; and further refine the intervention for a larger planned demonstration pilot. Methods: Interdisciplinary experts adapted AGS to create GamerFit-ASD, a 12-week intervention that included a progressive exergame schedule, …

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Effects Of Neighborhood Disadvantage And Peer Deviance On Conduct Problems: Interactions With Age Of Onset, Courtney Marie Goetz Feb 2023

Effects Of Neighborhood Disadvantage And Peer Deviance On Conduct Problems: Interactions With Age Of Onset, Courtney Marie Goetz

LSU Master's Theses

Youth with conduct problems (CP) generally fall into two developmental classifications, child-onset and adolescent-onset, which exhibit different causal processes and life course trajectories. Research suggests that child-onset CP is more likely to be related to individual predispositions, while adolescent-onset CP is more associated with social factors, such as peer delinquency. Living in impoverished and disorganized neighborhoods increases the risk for associating with deviant peers. Thus, the current study tested the hypothesis that neighborhood factors would be more strongly associated with adolescent-onset CP than child-onset CP, which would be explained by a greater association with deviant peers. Linear and negative binomial …

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Propaganda Word Counts, Michael Russo Feb 2023

Propaganda Word Counts, Michael Russo

Libraries Datasets

These files are the raw material for a study of the propaganda used by the George W. Bush administration to persuade Americans to support invading Iraq in 2003. They include documents from The Public Papers of the Presidents of the United States, George W. Bush; transcripts of television news shows on ABC, CBS, CNN, FOX, and NBC; and contemporaneous public opinion polling. All documents are from the 9/11/2001 to 3/19/2003 timeframe. Text analysis of the aforementioned documents is also included. The report of conclusions—as yet unpublished—will be found in a paper entitled “The Work of an Hour: A Case Study …

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Assessing Impacts Of Climate Change On Selected Foundation Species And Ecosystem Services In The South-Central Usa, R. James Ansley, Victor H. Rivera-Monroy, Kerry Griffis-Kyle, Bruce Hoagland, Amanda Emert, Todd Fagin, Scott R. Loss, Heather R. Mccarthy, Nicholas G. Smith, Elizabeth F. Waring Feb 2023

Assessing Impacts Of Climate Change On Selected Foundation Species And Ecosystem Services In The South-Central Usa, R. James Ansley, Victor H. Rivera-Monroy, Kerry Griffis-Kyle, Bruce Hoagland, Amanda Emert, Todd Fagin, Scott R. Loss, Heather R. Mccarthy, Nicholas G. Smith, Elizabeth F. Waring

Faculty Publications

Climate change, interacting with and exacerbating anthropogenic modifications to the landscape, is altering ecosystem structure and function, biodiversity, and species distributions. Among the most visible short-term impacts are the altered ecological roles of foundation species—those species, native or non-native—that create locally stable environmental conditions and strongly influence ecosystem services. Understanding the future of these species is crucial for projecting impacts on ecosystem services at both local and regional scales. Here we present foundation species by ecoregion study cases across the US South-Central Region (Louisiana, New Mexico, Oklahoma, and Texas), including C4 grasses, mesquite, and northern bobwhite in the Southern Great …

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Metagenomics And Metatranscriptomics Reveal Broadly Distributed, Active, Novel Methanotrophs In The Gulf Of Mexico Hypoxic Zone And In The Marine Water Column, Kathryn L. Howe, Kiley W. Seitz, Lauren G. Campbell, Brett J. Baker, J. Cameron Thrash, Nancy N. Rabalais, Mary Kate Rogener, Samantha B. Joye, Olivia U. Mason Feb 2023

Metagenomics And Metatranscriptomics Reveal Broadly Distributed, Active, Novel Methanotrophs In The Gulf Of Mexico Hypoxic Zone And In The Marine Water Column, Kathryn L. Howe, Kiley W. Seitz, Lauren G. Campbell, Brett J. Baker, J. Cameron Thrash, Nancy N. Rabalais, Mary Kate Rogener, Samantha B. Joye, Olivia U. Mason

Faculty Publications

The northern Gulf of Mexico (nGOM) hypoxic zone is a shallow water environment where methane, a potent greenhouse gas, fluxes from sediments to bottom water and remains trapped due to summertime stratification. When the water column is destratified, an active planktonic methanotrophic community could mitigate the efflux of methane, which accumulates to high concentrations, to the atmosphere. To investigate the possibility of such a biofilter in the nGOM hypoxic zone we performed metagenome assembly, and metagenomic and metatranscriptomic read mapping. Methane monooxygenase (pmoA) was an abundant transcript, yet few canonical methanotrophs have been reported in this environment, suggesting a role …

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Secular Trends In Physical Fitness Of Peruvian Children Living At High-Altitude, Carla Santos, Sara Pereira, Olga Vasconcelos, Go Tani, Donald Hedeker, Peter T. Katzmarzyk, José Maia, Alcibíades Bustamante Feb 2023

Secular Trends In Physical Fitness Of Peruvian Children Living At High-Altitude, Carla Santos, Sara Pereira, Olga Vasconcelos, Go Tani, Donald Hedeker, Peter T. Katzmarzyk, José Maia, Alcibíades Bustamante

Population and Public Health Science Faculty Publications

The physical fitness of children is an important marker of health, and monitoring its temporal changes provides important information for developing interventions. We aimed to: (1) describe secular trends in physical fitness across age, within each sex, in Peruvian schoolchildren; and (2) verify if these trends are also present when adjusted for changes in height and weight. We sampled 1590 children (707 in 2009; 883 in 2019), aged 6–11 years. Physical fitness was assessed with four tests from the EUROFIT battery. ANOVA and ANCOVA statistical models were used. Results showed that with increasing age, girls and boys were significantly stronger …

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Influence Of Soldiers On Exploratory Foraging Behavior In The Formosan Subterranean Termite, Coptotermes Formosanus (Blattodea: Rhinotermitidae), Joseph Mccarthy, Arjun Khadka, Hasim Hakanoglu, Qian Sun Feb 2023

Influence Of Soldiers On Exploratory Foraging Behavior In The Formosan Subterranean Termite, Coptotermes Formosanus (Blattodea: Rhinotermitidae), Joseph Mccarthy, Arjun Khadka, Hasim Hakanoglu, Qian Sun

Faculty Publications

Termites are eusocial insects that live in organized colonies consisting of reproductives, workers, and soldiers. Soldiers are specialized for defense but are expensive to maintain, as they are incapable of husbandry and must be fed and groomed by workers. The soldiers of several species influence foraging behavior by acting as scouts that initiate foraging or by mediating worker behavioral plasticity during food exploration. These behaviors imply that soldiers may play a keystone role in termite colony function, apart from defense. Subterranean termite workers tunnel through soil in search of food while accompanied by varying proportions of soldiers, depending on the …

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Wheat Long Noncoding Rnas From Organelle And Nuclear Genomes Carry Conserved Microrna Precursors Which May Together Comprise Intricate Networks In Insect Responses, Bala Ani Akpinar, Tugdem Muslu, Gadi V.P. Reddy, Munevver Dogramaci, Hikmet Budak Feb 2023

Wheat Long Noncoding Rnas From Organelle And Nuclear Genomes Carry Conserved Microrna Precursors Which May Together Comprise Intricate Networks In Insect Responses, Bala Ani Akpinar, Tugdem Muslu, Gadi V.P. Reddy, Munevver Dogramaci, Hikmet Budak

Faculty Publications

Long noncoding RNAs (lncRNAs) are a diverse class of noncoding RNAs that are typically longer than 200 nucleotides but lack coding potentials. Advances in deep sequencing technologies enabled a better exploration of this type of noncoding transcripts. The poor sequence conservation, however, complicates the identification and annotation of lncRNAs at a large scale. Wheat is among the leading food staples worldwide whose production is threatened by both biotic and abiotic stressors. Here, we identified putative lncRNAs from durum wheat varieties that differ in stem solidness, a major source of defense against wheat stem sawfly, a devastating insect pest. We also …

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Novel Index To Predict Mortality And Inform Malnutrition?, Jacob T. Mey Feb 2023

Novel Index To Predict Mortality And Inform Malnutrition?, Jacob T. Mey

Division of Basic Science Faculty Publications

No abstract provided.

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Opioid And Cannabis Co-Use: The Role Of Opioid Use To Cope With Negative Affect, Julia D. Buckner, Caroline R. Scherzer, Andrew H. Rogers, Michael J. Zvolensky Feb 2023

Opioid And Cannabis Co-Use: The Role Of Opioid Use To Cope With Negative Affect, Julia D. Buckner, Caroline R. Scherzer, Andrew H. Rogers, Michael J. Zvolensky

Faculty Publications

Introduction: The opioid epidemic is a significant public health concern, particularly among adults with chronic pain. There are high rates of cannabis co-use among these individuals and co-use is related to worse opioid-related outcomes. Yet, little work has examined mechanisms underlying this relationship. In line with affective processing models of substance use, it is possible that those who use multiple substances do so in a maladaptive attempt to cope with psychological distress. Method: We tested whether, among adults with chronic lower back pain (CLBP), the relation between co-use and more severe opioid-related problems would occur via the serial effects of …

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Wetland Occupancy By Duck Broods In Cropland-Dominated Landscapes Of The United States Prairie Pothole Region, Blake J. Mitchell, Catrina V. Terry, Kevin M. Ringelman, Kaylan M. Kemink, Michael J. Anteau, Adam K. Janke Feb 2023

Wetland Occupancy By Duck Broods In Cropland-Dominated Landscapes Of The United States Prairie Pothole Region, Blake J. Mitchell, Catrina V. Terry, Kevin M. Ringelman, Kaylan M. Kemink, Michael J. Anteau, Adam K. Janke

Faculty Publications

The Prairie Pothole Region (PPR) is globally important for breeding waterfowl but has been altered via wetland drainage and grassland conversion to accommodate agricultural land use. Thus, understanding the ecology of waterfowl in these highly modified landscapes is essential for their conservation. Brood occurrence is the cumulative outcome of key life-history events including pair formation and territory establishment, nest success, and early brood survival. We applied new technological advances in brood surveying methods to understand brood use of wetlands and how land use and wetland-specific factors influenced brood use of 413 wetlands in crop-dominated landscapes in the PPR of Iowa, …

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Glucagon-Like Peptide-1/Glucagon Receptor Agonism Associates With Reduced Metabolic Adaptation And Higher Fat Oxidation: A Randomized Trial, Karen D. Corbin, Elvis A. Carnero, Timothy D. Allerton, Joachim Tillner, Christopher P. Bock, Pierre Philippe Luyet, Britta Göbel, Kevin D. Hall, Stephanie A. Parsons, Eric Ravussin, Steven R. Smith Feb 2023

Glucagon-Like Peptide-1/Glucagon Receptor Agonism Associates With Reduced Metabolic Adaptation And Higher Fat Oxidation: A Randomized Trial, Karen D. Corbin, Elvis A. Carnero, Timothy D. Allerton, Joachim Tillner, Christopher P. Bock, Pierre Philippe Luyet, Britta Göbel, Kevin D. Hall, Stephanie A. Parsons, Eric Ravussin, Steven R. Smith

Clinical Research Faculty Publications

Objective: This study tested the hypothesis that treatment with the glucagon-like peptide-1/glucagon receptor agonist SAR425899 would lead to a smaller decrease in sleeping metabolic rate (SMR; kilocalories/day) than expected from the loss of lean and fat mass (metabolic adaptation). Methods: This Phase 1b, double-blind, randomized, placebo-controlled study was conducted at two centers in inpatient metabolic wards. Thirty-five healthy males and females with overweight and obesity (age = 36.5 ± 7.1 years) were randomized to a calorie-reduced diet (−1000 kcal/d) and escalating doses (0.06-0.2 mg/d) of SAR425899 (n = 17) or placebo (n = 18) for 19 days. SMR was measured …

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Early Time-Restricted Eating Affects Weight, Metabolic Health, Mood, And Sleep In Adherent Completers: A Secondary Analysis, Felicia L. Steger, Humaira Jamshed, David R. Bryan, Joshua S. Richman, Amy H. Warriner, Cody J. Hanick, Corby K. Martin, Sarah Jeanne Salvy, Courtney M. Peterson Feb 2023

Early Time-Restricted Eating Affects Weight, Metabolic Health, Mood, And Sleep In Adherent Completers: A Secondary Analysis, Felicia L. Steger, Humaira Jamshed, David R. Bryan, Joshua S. Richman, Amy H. Warriner, Cody J. Hanick, Corby K. Martin, Sarah Jeanne Salvy, Courtney M. Peterson

Clinical Research Faculty Publications

Objective: Data are mixed on whether intermittent fasting improves weight loss and cardiometabolic health. Here, the effects of time-restricted eating (TRE) in participants who consistently adhered ≥5 d/wk every week were analyzed. Methods: Ninety patients aged 25 to 75 years old with obesity were randomized to early TRE (eTRE; 8-hour eating window from 07:00 to 15:00) or a control schedule (≥12-hour window) for 14 weeks. A per-protocol analysis of weight loss, body composition, cardiometabolic health, and other end points was performed. Results: Participants who adhered to eTRE ≥5 d/wk every week had greater improvements in body weight (−3.7 ± 1.2 …

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Impact Of Early Time-Restricted Eating On Diet Quality, Meal Frequency, Appetite, And Eating Behaviors: A Randomized Trial, Felicia L. Steger, Humaira Jamshed, Corby K. Martin, Joshua S. Richman, David R. Bryan, Cody J. Hanick, Sarah Jeanne Salvy, Amy H. Warriner, Courtney M. Peterson Feb 2023

Impact Of Early Time-Restricted Eating On Diet Quality, Meal Frequency, Appetite, And Eating Behaviors: A Randomized Trial, Felicia L. Steger, Humaira Jamshed, Corby K. Martin, Joshua S. Richman, David R. Bryan, Cody J. Hanick, Sarah Jeanne Salvy, Amy H. Warriner, Courtney M. Peterson

Clinical Research Faculty Publications

Objective: Time-restricted eating (TRE) can reduce body weight, but it is unclear how it influences dietary patterns and behavior. Therefore, this study assessed the effects of TRE on diet quality, appetite, and several eating behaviors. Methods: Adults with obesity were randomized to early TRE plus energy restriction (eTRE + ER; 8-hour eating window from 7:00 a.m. to 3:00 p.m.) or a control eating schedule plus energy restriction (CON + ER; ≥12-hour window) for 14 weeks. Food intake was assessed via the Remote Food Photography Method, while eating patterns, appetite, and eating behaviors were assessed via questionnaires. Results: A total of …

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Evaluation Of The Peer Leadership For Physical Literacy Intervention: A Cluster Randomized Controlled Trial, Ryan M. Hulteen, David R. Lubans, Ryan E. Rhodes, Guy Faulkner, Yan Liu, Patti Jean Naylor, Nicole Nathan, Katrina J. Waldhauser, Colin M. Wierts, Mark R. Beauchamp Feb 2023

Evaluation Of The Peer Leadership For Physical Literacy Intervention: A Cluster Randomized Controlled Trial, Ryan M. Hulteen, David R. Lubans, Ryan E. Rhodes, Guy Faulkner, Yan Liu, Patti Jean Naylor, Nicole Nathan, Katrina J. Waldhauser, Colin M. Wierts, Mark R. Beauchamp

Faculty Publications

Purpose The purpose of this research was to develop, implement, and test the efficacy of a theory-driven, evidence-informed peer leadership program for elementary school students (Grade 6 and 7; age 11–12 years) and the Grade 3/4 students with whom they were partnered. The primary outcome was teacher ratings of their Grade 6/7 students’ transformational leadership behaviors. Secondary outcomes included: Grade 6/7 students’ leadership self-efficacy, as well as Grade 3/4 motivation, perceived competence, general self-concept, fundamental movement skills, school-day physical activity, and program adherence, and program evaluation. Methods We conducted a two-arm cluster randomized controlled trial. In 2019, 6 schools comprising …

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Framework Of The Alu Subfamily Evolution In The Platyrrhine Three-Family Clade Of Cebidae, Callithrichidae, And Aotidae, Jessica M. Storer, Jerilyn A. Walker, Jasmine N. Baker, Shifat Hossain, Christian Roos, Travis J. Wheeler, Mark A. Batzer Feb 2023

Framework Of The Alu Subfamily Evolution In The Platyrrhine Three-Family Clade Of Cebidae, Callithrichidae, And Aotidae, Jessica M. Storer, Jerilyn A. Walker, Jasmine N. Baker, Shifat Hossain, Christian Roos, Travis J. Wheeler, Mark A. Batzer

Faculty Publications

The history of Alu retroposons has been choreographed by the systematic accumulation of inherited diagnostic nucleotide substitutions to form discrete subfamilies, each having a distinct nucleotide consensus sequence. The oldest subfamily, AluJ, gave rise to AluS after the split between Strepsirrhini and what would become Catarrhini and Platyrrhini. The AluS lineage gave rise to AluY in catarrhines and to AluTa in platyrrhines. Platyrrhine Alu subfamilies Ta7, Ta10, and Ta15 were assigned names based on a standardized nomenclature. However, with the subsequent intensification of whole genome sequencing (WGS), large scale analyses to characterize Alu subfamilies using the program COSEG identified entire …

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The Role Of Nutrition In Mitigating The Effects Of Covid-19 From Infection Through Pasc, Jacob T. Mey, John P. Kirwan, Christopher L. Axelrod Feb 2023

The Role Of Nutrition In Mitigating The Effects Of Covid-19 From Infection Through Pasc, Jacob T. Mey, John P. Kirwan, Christopher L. Axelrod

Division of Basic Science Faculty Publications

The expansive and rapid spread of the SARS-CoV-2 virus has resulted in a global pandemic of COVID-19 infection and disease. Though initially perceived to be acute in nature, many patients report persistent and recurrent symptoms beyond the infectious period. Emerging as a new epidemic, “long-COVID”, or post-acute sequelae of coronavirus disease (PASC), has substantially altered the lives of millions of people globally. Symptoms of both COVID-19 and PASC are individual, but share commonality to established respiratory viruses, which include but are not limited to chest pain, shortness of breath, fatigue, along with adverse metabolic and pulmonary health effects. Nutrition plays …

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Appraisal Of Clinical Care Practices For Child Obesity Treatment. Part I: Interventions, Asheley C. Skinner, Amanda E. Staiano, Sarah C. Armstrong, Shari L. Barkin, Sandra G. Hassink, Jennifer E. Moore, Jennifer S. Savage, Helene Vilme, Ashley E. Weedn, Janice Liebhart, Jeanne Lindros, Eileen M. Reilly Feb 2023

Appraisal Of Clinical Care Practices For Child Obesity Treatment. Part I: Interventions, Asheley C. Skinner, Amanda E. Staiano, Sarah C. Armstrong, Shari L. Barkin, Sandra G. Hassink, Jennifer E. Moore, Jennifer S. Savage, Helene Vilme, Ashley E. Weedn, Janice Liebhart, Jeanne Lindros, Eileen M. Reilly

Population and Public Health Science Faculty Publications

The objective of this technical report is to provide clinicians with evidence-based, actionable information upon which to make assessment and treatment decisions for children and adolescents with obesity. In addition, this report will provide an evidence base to inform clinical practice guidelines for the management and treatment of overweight and obesity in children and adolescents. To this end, the goal of this report was to identify all relevant studies to answer 2 overarching key questions: (KQ1) “What are clinically based, effective treatments for obesity?” and (KQ2) “What is the risk of comorbidities among children with obesity?” See Appendix 1 for …

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Appraisal Of Clinical Care Practices For Child Obesity Treatment. Part Ii: Comorbidities, Asheley C. Skinner, Amanda E. Staiano, Sarah C. Armstrong, Shari L. Barkin, Sandra G. Hassink, Jennifer E. Moore, Jennifer S. Savage, Helene Vilme, Ashley E. Weedn, Janice Liebhart, Jeanne Lindros, Eileen M. Reilly Feb 2023

Appraisal Of Clinical Care Practices For Child Obesity Treatment. Part Ii: Comorbidities, Asheley C. Skinner, Amanda E. Staiano, Sarah C. Armstrong, Shari L. Barkin, Sandra G. Hassink, Jennifer E. Moore, Jennifer S. Savage, Helene Vilme, Ashley E. Weedn, Janice Liebhart, Jeanne Lindros, Eileen M. Reilly

Population and Public Health Science Faculty Publications

The objective of this technical report is to provide clinicians with actionable evidence-based information upon which to make treatment decisions. In addition, this report will provide an evidence base on which to inform clinical practice guidelines for the management and treatment of overweight and obesity in children and adolescents. To this end, the goal of this report was to identify all relevant studies to answer 2 overarching key questions: (KQ1) “What are effective clinically based treatments for obesity?” and (KQ2) “What is the risk of comorbidities among children with obesity?” See Appendix 1 for the conceptual framework and a priori …

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Envirome-Wide Associations Enhance Multi-Year Genome-Based Prediction Of Historical Wheat Breeding Data, Germano Costa-Neto, Leonardo Crespo-Herrera, Nick Fradgley, Keith Gardner, Alison R. Bentley, Susanne Dreisigacker, Roberto Fritsche-Neto, Osval A. Montesinos-López, Jose Crossa Feb 2023

Envirome-Wide Associations Enhance Multi-Year Genome-Based Prediction Of Historical Wheat Breeding Data, Germano Costa-Neto, Leonardo Crespo-Herrera, Nick Fradgley, Keith Gardner, Alison R. Bentley, Susanne Dreisigacker, Roberto Fritsche-Neto, Osval A. Montesinos-López, Jose Crossa

Faculty Publications

Linking high-throughput environmental data (enviromics) to genomic prediction (GP) is a cost-effective strategy for increasing selection intensity under genotype-by-environment interactions (G × E). This study developed a data-driven approach based on Environment–Phenotype Association (EPA) aimed at recycling important G × E information from historical breeding data. EPA was developed in two applications: (1) scanning a secondary source of genetic variation, weighted from the shared reaction-norms of past-evaluated genotypes and (2) pinpointing weights of the similarity among trial-sites (locations), given the historical impact of each envirotyping data variable for a given site. These results were then used as a dimensionality reduction …

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