Digital Commons Network^™

Residential Building Flood Risk Assessment And The Benefits Of Home Elevation, Ayat Al Assi

LSU Doctoral Dissertations

Evaluating flood risk is an essential component of understanding and increasing community resilience. A robust approach for quantifying flood risk in terms of average annual loss (AAL) in dollars is needed to provide valuable information for stakeholder decision-making inside and outside the special flood hazard area (SFHA, which corresponds to the 100-year floodplain). To further inform flood mitigation strategies, quantifying flood risk reduction with home elevation above an initial first-floor height (FFH₀) and the cost effectiveness of federal mitigation assistance for elevation are important steps to enhance awareness of the effect of elevation in reducing flood risk. …

Impact Of Blood Flow Restricted Resistance Training On Skeletal Muscle Strength, Hypertrophy, Fatigue, Mitochondrial Response, And Activation, Brett Davis

LSU Doctoral Dissertations

Abstract

Blood flow restricted resistance exercise (BFR-RE) is a novel method that is effective at increasing strength and hypertrophy using much lower loads than the higher loads typical in progressive resistance exercise. However, the effects of BFR-RE on skeletal muscle fatigue, mitochondrial response, and activation are still being explored. This dissertation will discuss the impacts of BFR-RE, how it affects college-aged individuals that are trained and untrained, and the effects of BFR-RE on skeletal muscle fatigue, mitochondrial response, and activation.

The first study examined the effects of 6-weeks of low load blood flow restricted resistance exercise (LLBFR) on muscular strength, …

Expressing Outrage, Re-Inventing Hope: Performing Nationhood In Nigerian Standup Comedy., Babasinmisola Fadirepo

LSU Doctoral Dissertations

The intersection of the Nigerian national identity and popular culture has been overwhelmingly located in the Nigerian movie industry and the Afrobeats, the flourishing Nigerian popular music. Further, when intervention about the Nigerian national identity is located within standup comedy performances, such analysis is vastly linguistic analysis of the performance. Through the lens of performance studies, this dissertation extends the discussion of the Nigerian national identity to standup comedy performances. In addition to the linguistic analysis of select Nigerian standup comedy performances, this work considers the location, costumes of comic acts, and the settings of the performance studied. Simply, this …

Regulation Of Nucleotide Excision Repair, Wenzhi Gong

LSU Doctoral Dissertations

Nucleotide excision repair (NER), a “cut and patch” mechanism, has two subpathways, namely transcription coupled repair (TCR) and global genome repair (GGR). TCR rapidly removes UV photoproduct (UV PP) in the transcribed strand (TS) of an actively transcribed gene, whereas GGR removes those DNA lesions throughout the genome. This dissertation mainly focused on identifying novel factors that function in NER and investigating the potential molecular mechanisms underlying initial damage recognition and downstream processes in NER. We identified Rpb7, a subunit of RNA polymerase II, represses TCR via its multiple regions. Specifically, the conserved region of Rpb7 that interacts with the …

Autism, Comorbidities, And Adaptive Functioning: A Potential Moderator, Joshua J. Montrenes

LSU Doctoral Dissertations

Deficits in adaptive functioning and the presence of comorbid symptomatology are both commonly associated with autism spectrum disorder (ASD). Previous research has identified relationships between functional level (e.g., intellectual quotient [IQ], adaptive functioning [AF]) and comorbid symptomatology in ASD. However, further insight into the relationship between AF, comorbid psychopathology, and ASD is unclear. Specifically, how AF affects the relationship between ASD and comorbid conditions is not well understood. Whether AF moderates the relationship between autism symptom severity and comorbid symptom severity in toddlers with ASD was examined. ASD symptom severity positively correlated with comorbid symptom severity across domains and negatively …

With Every Name But Yours: A New Orchestration Of Clémence De Grandval's Stabat Mater, David Walters

LSU Doctoral Dissertations

Clémence de Grandval was a late-Romantic composer whose extensive body of work, high profile performances, and numerous accolades should have garnered prominent placement among her contemporaries. Yet her vast collection of orchestral, choral, operatic, and other stage works have been all but forgotten.

Grandval’s Stabat Mater counted among her most popular works. Though the extant score for choir, harmonium (or organ), and piano explicitly references orchestral accompaniment1 , none of the parts or full score are available. Rather than providing a conductor’s guide or chord-by-chord analysis of Grandval’s work, this document breathes new life into this lost masterpiece by orchestrating …

Year-Round Weather Alters Nest-Provisioning Rates In A Migratory Owl, Eliza D. Stein, Stephen R. Midway, Brian D. Linkhart

Faculty Publications

As global temperatures and precipitation become more extreme, habitat specialists are at particular risk of being pushed past their environmental tolerance limits. Flammulated Owls (Psiloscops flammeolus) are small migratory owls that breed in temperate conifer forests of western North America. Their highly specialized nesting and foraging requirements make them indicators of ecosystem health. Using 17 years of nest observations, we investigated how annual weather patterns affected Flammulated Owl nesting and foraging behaviors during the breeding season. We used generalized linear models with a changepoint parameter to evaluate nest provisioning and nestling growth rates in years of extreme temperature and precipitation. …

A Systematic Literature Review Of Cleanroom Ventilation And Air Distribution Systems, Arup Bhattacharya, Mohammad Saleh Nikoopayan Tak, Shervin Shoai-Naini, Fred Betz, Ehsan Mousavi

Faculty Publications

Cleanroom ventilation systems are well-established; however, the advantages and limitations of current practices need to be examined and explained further. This study begins by looking over the history of cleanroom ventilation systems that creates the basis for understanding ventilation rate specifications, terminologies employed in ventilation effectiveness, and recognizing scientific studies that correlate ventilation effectiveness with air change rates. This systematic review includes a comprehensive summary that contains a set of historical data and evidence that may be used to specify ventilation requirements in cleanrooms. Scientific articles are classified in terms of laboratory experiments, simulations/numerical analysis, or hybrid. HVAC designers and …

Eating Disorders In Weight-Related Therapy (Edit): Protocol For A Systematic Review With Individual Participant Data Meta-Analysis Of Eating Disorder Risk In Behavioural Weight Management, Hiba Jebeile, Natalie B. Lister, Sol Libesman, Kylie E. Hunter, Caitlin M. Mcmaster, Brittany J. Johnson, Louise A. Baur, Susan J. Paxton, Sarah P. Garnett, Amy L. Ahern, Denise E. Wilfley, Sarah Maguire, Amanda Sainsbury, Katharine Steinbeck, Lisa Askie, Caroline Braet, Andrew J. Hill, Dasha Nicholls, Rebecca A. Jones, Genevieve Dammery, Alicia M. Grunseit, Kelly Cooper, Theodore K. Kyle, Faith A. Heeren, Fiona Quigley, Rachel D. Barnes, Melanie K. Bean, Kristine Beaulieu, Maxine Bonham, Kerri N. Boutelle, Braulio Henrique Magnani Branco, Simona Calugi, Michelle I. Cardel, Kelly Carpenter

Clinical Research Faculty Publications

The Eating Disorders In weight-related Therapy (EDIT) Collaboration brings together data from randomised controlled trials of behavioural weight management interventions to identify individual participant risk factors and intervention strategies that contribute to eating disorder risk. We present a protocol for a systematic review and individual participant data (IPD) meta-analysis which aims to identify participants at risk of developing eating disorders, or related symptoms, during or after weight management interventions conducted in adolescents or adults with overweight or obesity. We systematically searched four databases up to March 2022 and clinical trials registries to May 2022 to identify randomised controlled trials of …

Genome-Wide Association Analysis Identifies Ancestry-Specific Genetic Variation Associated With Acute Response To Metformin And Glipizide In Sugar-Mgh, Josephine H. Li, Laura N. Brenner, Varinderpal Kaur, Katherine Figueroa, Philip Schroeder, Alicia Huerta-Chagoya, Alicia Huerta-Chagoya, Ji Chen, Cassandra N. Spracklen, Gaëlle Marenne, Arushi Varshney, Laura J. Corbin, Jian’An Luan, Sara M. Willems, Ying Wu, Xiaoshuai Zhang, Momoko Horikoshi, Thibaud S. Boutin, Reedik Mägi, Johannes Waage, Ruifang Li-Gao, Kei Hang Katie Chan, Jie Yao, Mila D. Anasanti, Audrey Y. Chu, Annique Claringbould, Jani Heikkinen, Jaeyoung Hong, Jouke Jan Hottenga, Shaofeng Huo, Marika A. Kaakinen, Tin Louie, Winfried März, Hortensia Moreno-Macias

Population and Public Health Science Faculty Publications

Aims/hypothesis: Characterisation of genetic variation that influences the response to glucose-lowering medications is instrumental to precision medicine for treatment of type 2 diabetes. The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH) examined the acute response to metformin and glipizide in order to identify new pharmacogenetic associations for the response to common glucose-lowering medications in individuals at risk of type 2 diabetes. Methods: One thousand participants at risk for type 2 diabetes from diverse ancestries underwent sequential glipizide and metformin challenges. A genome-wide association study was performed using the Illumina Multi-Ethnic Genotyping …

Preliminary Validation Of Digital Photography To Assess The Home Food Environment, Daniela Quan, Isaac Michael, Elizabeth Gollub

Faculty Publications

The home food environment (HFE), the availability and accessibility of foods and food products within the home, has a strong influence on healthy eating behaviors. Studies assessing the HFE commonly utilize a home food inventory (HFI) for data collection. However, this approach tends to be burdensome for participants. This study validated a low-burden digital photo method for assessing the home food environment and confirmed that this method is preferred by participants. Study participants completed an HFI, submitted photos of household foods, then identified preference for the HFI or photo reporting method. Researchers completed an HFI based on each participant’s photo …

Evidence For Two Soybean Looper Strains In The United States With Limited Capacity For Cross-Hybridization, Rodney N. Nagoshi, Jeffrey A. Davis, Robert L. Meagher, Fred R. Musser, Graham P. Head, Hector Portillo, Henry Teran

Faculty Publications

The noctuid moth soybean looper (SBL), Chrysodeixis includens (Walker) is an economically important pest of soybeans (Glycine max (L.) Merr.) in the southeastern United States. It has characteristics that are of particular concern for pest mitigation that include a broad host range, the capacity for annual long-distance flight, and resistance in some populations to important pesticides such as pyrethroids and chitin synthesis inhibitor. The biology of SBL in the United States resembles that of the fellow noctuid fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith), a major pest of corn and several other crops. FAW exhibits a population structure in that …

Investigating The Migratory Behavior Of Soybean Looper, A Major Pest Of Soybean, Through Comparisons With The Corn Pest Fall Armyworm Using Mitochondrial Haplotypes And A Sex-Linked Marker, Rodney N. Nagoshi, Jeffrey A. Davis, Robert L. Meagher, Fred R. Musser, Graham P. Head, Hector Portillo, Henry Teran

Faculty Publications

The Noctuid moth soybean looper (SBL), Chrysodeixis includens (Walker), is an economically important pest of soybean (Glycine max (Linnaeus) Merrill). Because it is not known to survive freezing winters, permanent populations in the United States are believed to be limited to the southern regions of Texas and Florida, yet its geographical range of infestations annually extend to Canada. This indicates annual migrations of thousands of kilometers during the spring and summer growing season. This behavior is like that of the fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith), also a Noctuid that is a major global pest of corn. SBL and …

Louisiana Agriculture Magazine, Summer 2023

Louisiana Agriculture

Rice, alligators and sugarcane are quintessential Louisiana products, and LSU AgCenter researchers and extension agents devote themselves to helping the producers who grow them. Economists are finding ways to improve the market for alligators while specialists focus on innovation in the sugar industry and creating new varieties of rice.

AgCenter researchers also have an eye on the natural world. They are protecting the roseau cane that thrives on the coast and the ironwood trees of Guam. All these efforts are detailed in this issue of Louisiana Agriculture magazine.

Clathrin-Mediated Endocytosis Facilitates The Internalization Of Magnaporthe Oryzae Effectors Into Rice Cells, Ely Oliveira-Garcia, Tej Man Tamang, Jungeun Park, Melinda Dalby, Magdalena Martin-Urdiroz, Clara Rodriguez Herrero, An Hong Vu, Sunghun Park, Nicholas J. Talbot, Barbara Valent

Faculty Publications

Fungi and oomycetes deliver effectors into living plant cells to suppress defenses and control plant processes needed for infection. Little is known about the mechanism by which these pathogens translocate effector proteins across the plasma membrane into the plant cytoplasm. The blast fungus Magnaporthe oryzae secretes cytoplasmic effectors into a specialized biotrophic interfacial complex (BIC) before translocation. Here, we show that cytoplasmic effectors within BICs are packaged into punctate membranous effector compartments that are occasionally observed in the host cytoplasm. Live cell imaging with fluorescently labeled proteins in rice (Oryza sativa) showed that these effector puncta colocalize with the plant …

A Cyclical Phenomenon Among Stock & Commodity Markets, Hector O. Zapata, Junior E. Betanco, Maria Bampasidou, Michael Deliberto

Faculty Publications

Considerable studies have examined the relationship between commodity markets and stock markets. This paper studies the cyclical relationship between commodity markets and stock markets with implications for investing based on index relationships. Stock markets are represented by the U.S. S&P 500 index and aggregate commodity markets by the U.S. producer price index (PPI). Tradeable market indexes readily available to investors, namely the S&P GSCI Index and the Bloomberg Commodity Index (BCOM), are also studied. An optimal bandpass filter is used to estimate the cyclical component using a pricing-performance measure of the S&P 500 relative to the PPI, based on annual …

Extended Sentinel Monitoring Of Helicoverpa Zea Resistance To Cry And Vip3aa Toxins In Bt Sweet Corn: Assessing Changes In Phenotypic And Allele Frequencies Of Resistance, Galen P. Dively, Tom P. Kuhar, Sally V. Taylor, Helene Doughty, Kristian Holmstrom, Daniel O. Gilrein, Brian A. Nault, Joseph Ingerson-Mahar, Anders Huseth, Dominic Reisig, Shelby Fleischer, David Owens, Kelley Tilmon, Francis Reay-Jones, Pat Porter, Jocelyn Smith, Julien Saguez, Jason Wells, Caitlin Congdon, Holly Byker, Bryan Jensen, Chris Difonzo, William D. Hutchison, Eric Burkness, Robert Wright, Michael Crossley, Heather Darby, Tom Bilbo, Nicholas Seiter, Christian Krupke, Craig Abel, Brad S. Coates, Bradley Mcmanus

Faculty Publications

Transgenic corn and cotton that produce Cry and Vip3Aa toxins derived from Bacillus thuringiensis (Bt) are widely planted in the United States to control lepidopteran pests. The sustainability of these Bt crops is threatened because the corn earworm/bollworm, Helicoverpa zea (Boddie), is evolving a resistance to these toxins. Using Bt sweet corn as a sentinel plant to monitor the evolution of resistance, collaborators established 146 trials in twenty-five states and five Canadian provinces during 2020–2022. The study evaluated overall changes in the phenotypic frequency of resistance (the ratio of larval densities in Bt ears relative to densities in non-Bt ears) …

Large Uncertainties In Co2 Water–Air Outgassing Estimation With Gas Exchange Coefficient Kt For A Large Lowland River, Anamika Dristi, Y. Jun Xu

Faculty Publications

Aquatic CO2 emission is typically estimated (i.e., not measured) through a gas exchange balance. Several factors can affect the estimation, primarily flow velocity and wind speed, which can influence a key parameter, the gas exchange coefficient KT in the balancing approach. However, our knowledge of the uncertainty of predictions using these factors is rather limited. In this study, we conducted a numeric assessment on the impact of river flow velocity and wind speed on KT and the consequent CO2 emission rate. As a case study, we utilized 3-year (2019–2021) measurements on the partial pressure of dissolved carbon dioxide (pCO2) in …

Substantially Enhanced Landscape Carbon Sink Due To Reduced Terrestrial-Aquatic Carbon Transfer Through Soil Conservation In The Chinese Loess Plateau, Lishan Ran, Nufang Fang, Xuhui Wang, Shilong Piao, Chun Ngai Chan, Siliang Li, Yi Zeng, Zhihua Shi, Mingyang Tian, Yi Jun Xu, Junyu Qi, Boyi Liu

Faculty Publications

Soil conservation is of global importance, as accelerated soil erosion by human activity is a primary threat to ecosystem viability. However, the significance and role of soil conservation in reshaping landscape carbon (C) accounting has not been comprehensively integrated in the terrestrial C sink. Here, we present the first integrated assessment of the modified terrestrial C sink and aquatic C transport due to soil conservation for the semiarid Chinese Loess Plateau (CLP), the world's most vulnerable region to soil erosion. We show a surprisingly low terrestrial-aquatic C transfer that offset the terrestrial net ecosystem productivity by only 7.5%, which we …

Obesogens And Obesity: State-Of-The-Science And Future Directions Summary From A Healthy Environment And Endocrine Disruptors Strategies Workshop, Jerrold J. Heindel, Jessica A. Alvarez, Ella Atlas, Matthew C. Cave, Vaia Lida Chatzi, David Collier, Barbara Corkey, Douglas Fischer, Michael I. Goran, Sarah Howard, Scott Kahan, Matthias Kayhoe, Suneil Koliwad, Catherine M. Kotz, Michele La Merrill, Tim Lobstein, Carey Lumeng, David S. Ludwig, Robert H. Lustig, Pete Myers, Angel Nadal, Leonardo Trasande, Leanne M. Redman, Matthew S. Rodeheffer, Robert M. Sargis, Jacqueline M. Stephens, Thomas R. Ziegler, Bruce Blumberg

Division of Basic Science Faculty Publications

On September 7 and 8, 2022, Healthy Environment and Endocrine Disruptors Strategies, an Environmental Health Sciences program, convened a scientific workshop of relevant stakeholders involved in obesity, toxicology, or obesogen research to review the state of the science regarding the role of obesogenic chemicals that might be contributing to the obesity pandemic. The workshop's objectives were to examine the evidence supporting the hypothesis that obesogens contribute to the etiology of human obesity; to discuss opportunities for improved understanding, acceptance, and dissemination of obesogens as contributors to the obesity pandemic; and to consider the need for future research and potential mitigation …

Current Discoveries And Future Implications Of Eating Disorders, Bing Feng, Jerney Harms, Emily Chen, Peiyu Gao, Pingwen Xu, Yanlin He

Division of Basic Science Faculty Publications

Eating disorders (EDs) are characterized by severe disturbances in eating behaviors and can sometimes be fatal. Eating disorders are also associated with distressing thoughts and emotions. They can be severe conditions affecting physical, psychological, and social functions. Preoccupation with food, body weight, and shape may also play an important role in the regulation of eating disorders. Common eating disorders have three major types: anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). In some cases, EDs can have serious consequences for an individual’s physical and mental health. These disorders often develop during adolescence or early adulthood and affect …

Long-Term Capture Data Uncover Shifts In The Daily Activity Patterns Of Amazonian Birds, Cameron L. Rutt, Philip C. Stouffer, Bruna R. Amaral, David A. Luther

Faculty Publications

Although the duration of biological rhythms varies from milliseconds to decades, daily cycles are especially widespread for individual organisms. These circadian rhythms are synchronized by light–dark cycles, which govern predictable changes in other microclimate variables. Despite the fixed, regular nature of these abiotic cycles at low latitudes, little is known about how different animals structure activity along these gradients. We used 25 years of capture–recapture data and ~ 25 000 unique captures to characterize ‘activity' (time of capture) for 65 species of Amazonian birds in the lowest forest stratum (0–2.5 m). To quantify vertical niche breadths, we also measured foraging …

Measuring In Vivo Adipose Tissue Kinetics In Humans Using The Deuterium (2h)-Labeling Approach, Dereck Kibodeaux, Jonathan Savoie, Eric Ravussin, Mark Fitch, Marc K. Hellerstein, Ursula White

Clinical Research Faculty Publications

White adipose tissue is a highly plastic organ that is necessary to maintain whole-body energy homeostasis. The adipose tissue mass and changes in the fat mass or distribution are regulated by changes in the synthesis and breakdown (i.e., turnover) of adipose cells and triacylglycerols. Evidence suggests that the manner and magnitude of subcutaneous adipose tissue expansion (i.e., hypertrophy vs. hyperplasia) and turnover can influence metabolic health, as adipogenesis has been implicated in the pathogenesis of obesity and related diseases. Despite the potential role of adipose turnover in human health, there is a lack of knowledge about the in vivo kinetics …

Current Status Of Us Soil Test Phosphorus And Potassium Recommendations And Analytical Methods, Sarah E. Lyons, Jason D. Clark, Deanna L. Osmond, Md Rasel Parvej, Austin W. Pearce, Nathan A. Slaton, John T. Spargo

Faculty Publications

Soil testing is the foundation of fertilizer recommendations in the United States. Fertilizer recommendations have primarily been developed by land-grant universities with limited coordination among programs. The individual state approach to develop fertilizer recommendations has resulted in discrepancies in recommended soil sampling protocols, soil analysis methods, and fertilizer recommendations at similar soil nutrient levels. A national survey was developed to summarize the status of soil testing and fertility work in the United States to inform future collaborative efforts among states and regions and identify opportunities to harmonize recommendation guidelines. Topics included relevant funding, multi-state collaborations, state soil-test recommendations and related …

Extensive Independent Amplification Of Platy-1 Retroposons In Tamarins, Genus Saguinus, Jessica M. Storer, Jerilyn A. Walker, Thomas O. Beckstrom, Mark A. Batzer

Faculty Publications

Platy-1 retroposons are short interspersed elements (SINEs) unique to platyrrhine primates. Discovered in the common marmoset (Callithrix jacchus) genome in 2016, these 100 bp mobile element insertions (MEIs) appeared to be novel drivers of platyrrhine evolution, with over 2200 full-length members across 62 different subfamilies, and strong evidence of ongoing proliferation in C. jacchus. Subsequent characterization of Platy-1 elements in Aotus, Saimiri and Cebus genera, suggested that the widespread mobilization detected in marmoset (family Callithrichidae) was perhaps an anomaly. Two additional Callithrichidae genomes are now available, a scaffold level genome assembly for Saguinus imperator (tamarin; SagImp_v1) and a chromosome-level assembly …

Exploring Barriers To Sars-Cov-2 Testing Uptake In Underserved Black Communities In Louisiana, Peter T. Katzmarzyk, Candice A. Myers, Michelle R. Nelson, Kara D. Denstel, Emily F. Mire, Robert L. Newton, Stephanie T. Broyles, John P. Kirwan

Division of Basic Science Faculty Publications

Objective: To collect qualitative data on approaches that can potentially reduce barriers to, and create strategies for, increasing SARS-CoV-2 testing uptake in underserved Black communities in Louisiana. Methods: A series of eight focus groups, including 41 participants, were conducted in primarily Black communities. The Nominal Group Technique (NGT) was used to determine perceptions of COVID-19 as a disease, access to testing, and barriers limiting testing uptake. Results: Common barriers to SARS-CoV-2 testing were identified as lack of transportation, misinformation/lack of information, lack of time/long wait times, fear of the test being uncomfortable and/or testing positive, the cost of testing, and …

Association Between Maternal And Infant Screen Time With Child Growth And Development: A Longitudinal Study, Chelsea L. Kracht, Leanne M. Redman, Jayne Bellando, Rebecca A. Krukowski, Aline Andres

Clinical Research Faculty Publications

Background: Sedentary screen time is an early, modifiable risk factor for obesity and poor child development. Objectives: To examine the relationship between maternal and infant screen time with child growth and development. Methods: Pregnant women were recruited for a cohort study related to maternal and infant development. Screen time was assessed in mothers during pregnancy, and subsequently in children at 3 months, 12 months, and 24 months of age. Child anthropometry was measured, and nuclear magnetic resonance quantified child fat mass. Fat mass index (FMI) was calculated. The Bayley Scales of Infant Development-III were used to assess child development. Linear …

A Feasibility Study Of The Combination Of Intranasal Insulin With Dulaglutide For Cognition In Older Adults With Metabolic Syndrome At High Dementia Risk – Study Rationale And Design, Tal Davidy, Iscka Yore, Tali Cukierman-Yaffe, Ramit Ravona-Springer, Abigail Livny, Orit H. Lesman-Segev, Yossi Azuri, Owen Carmichael, Dimitrios Kapogiannis, Henrik Zetterberg, Hung Mo Lin, Mary Sano, Michal Schnaider Beeri

Clinical Research Faculty Publications

Introduction: We present the rationale and design of a double-blind placebo-controlled feasibility trial combining intranasal insulin (INI) with dulaglutide, a GLP-1 receptor agonist, to improve cognition in older adults with metabolic syndrome (MetS) and mild cognitive impairment (MCI). Since both INI and dulaglutide have beneficial effects on the cerebrovascular disease (CVD), we anticipate that improved CVD will underlie the hypothesized cognitive benefits. Methods: This 12-months trial will include 80 older adults aged > 60 with MetS and MCI, randomized to 4 groups: INI/dulaglutide injection, intranasal placebo/dulaglutide injection, INI/placebo injection, and intranasal placebo/placebo injection. Feasibility of combining INI with dulaglutide will be …

Gene Editing Provides A Tool To Investigate Genes Involved In Reproduction Of Pigs, Rodney D. Geisert, Destiny N. Johns, Caroline A. Pfeiffer, Riley M. Sullivan, Caroline G. Lucas, Constantine A. Simintiras, Bethany K. Redel, Kevin D. Wells, Thomas E. Spencer, Randall S. Prather

Faculty Publications

CRISPR-Cas9 gene editing technology provides a method to generate loss-of-function studies to investigate, in vivo, the specific role of specific genes in regulation of reproduction. With proper design and selection of guide RNAs (gRNA) designed to specifically target genes, CRISPR-Cas9 gene editing allows investigation of factors proposed to regulate biological pathways involved with establishment and maintenance of pregnancy. The advantages and disadvantages of using the current gene editing technology in a large farm species is discussed. CRISPR-Cas9 gene editing of porcine conceptuses has generated new perspectives for the regulation of endometrial function during the establishment of pregnancy. The delicate orchestration …

Medical Libraries And Their Complicated Past: An Exploration Of The Historical Connections Between Medical Collections And Racial Science, Raymond Pun, Patrice R. Green, Nicollette Davis

Faculty Publications

For over a millennium, libraries and library workers have advanced the knowledge of human science by building, preserving, and sharing collections and research. Historically, libraries have also aligned their institutional responsibilities to adhere to and support the values and virtues of oppressive and colonial practices. Library history has shown the mistreatments and denials of information access of marginalized groups. The history of libraries in the health and medical sciences reveals how these institutions and their workers have preserved and circulated research studies perpetuating racial science. This commentary highlights how such institutions shape and contribute to racial science in the field …