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Indirect Effects Of Soldier Healthy Eating And Physical Activity On Suicidal Ideation Through Psychological Health Symptoms In Active-Duty Military, Nicolas Oakey-Frost, Benjamin Trachik, Michelle L. Ganulin, Mathew L. Lopresti, Michael N. Dretsch, Raymond P. Tucker Jan 2022

Indirect Effects Of Soldier Healthy Eating And Physical Activity On Suicidal Ideation Through Psychological Health Symptoms In Active-Duty Military, Nicolas Oakey-Frost, Benjamin Trachik, Michelle L. Ganulin, Mathew L. Lopresti, Michael N. Dretsch, Raymond P. Tucker

Faculty Publications

The suicide rate within the military continues to rise. New approaches for prevention are needed which capitalize on existing strengths, are scalable at multiple levels, and promote mental fortitude. Healthy eating (HE) and physical activity (PA) represent scalable practices and methods for promoting mental health and protective factors within the military. A cross-sectional sample of N = 1019 active-duty Soldiers completed self-report measures of HE, PA, major depressive disorder (MDD) symptoms, generalized anxiety disorder (GAD) symptoms, and suicidal ideation (SI). Moderated mediation analyses using bootstrapping techniques were used to determine if HE and PA interact to relate to lower SI …

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Effects Of Maternal Diabetes And Diet On Gene Expression In The Murine Placenta, Claudia Kappen, Claudia Kruger, J. Michael Salbaum Jan 2022

Effects Of Maternal Diabetes And Diet On Gene Expression In The Murine Placenta, Claudia Kappen, Claudia Kruger, J. Michael Salbaum

Division of Basic Science Faculty Publications

Adverse exposures during pregnancy have been shown to contribute to susceptibility for chronic diseases in offspring. Maternal diabetes during pregnancy is associated with higher risk of pregnancy complications, structural birth defects, and cardiometabolic health impairments later in life. We showed previously in a mouse model that the placenta is smaller in diabetic pregnancies, with reduced size of the junctional zone and labyrinth. In addition, cell migration is impaired, resulting in ectopic accumulation of spongiotrophoblasts within the labyrinth. The present study had the goal to identify the mechanisms underlying the growth defects and trophoblast migration abnormalities. Based upon gene expression assays …

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2022 Ecei Annual Report, Lsu Early Childhood Education Institute Jan 2022

2022 Ecei Annual Report, Lsu Early Childhood Education Institute

Early Childhood Education Institute Annual Reports

No abstract provided.

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African Americans' Perceptions Of Nutrition Interventions: A Scoping Review, Matthew Greene, Bailey Houghtaling, Claire Sadeghzadeh, Molly De Marco, De'jerra Bryant, Randa Morgan, Denise Holston Jan 2022

African Americans' Perceptions Of Nutrition Interventions: A Scoping Review, Matthew Greene, Bailey Houghtaling, Claire Sadeghzadeh, Molly De Marco, De'jerra Bryant, Randa Morgan, Denise Holston

Faculty Publications

Nutrition education and policy, systems, and environmental (PSE) change interventions may be able to address food insecurity and obesity, conditions which are disproportionately experienced by African Americans. Work that seeks to address these disparities and advance social justice should uplift and learn from participant voices, particularly from marginalized groups. This scoping review aimed to summarize the available literature describing African Americans' perceptions of and experiences participating in nutrition interventions. We conducted an electronic literature search with the assistance of a research librarian which encompassed 6 databases (MEDLINE, PyscINFO, Agricola, ERIC, SocINDEX, and ProQuest Dissertations and Theses) and identified 35 sources …

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Development Of A Memories Vocabulary (Memvoc) For Food Products Using Coffee As Model, Adan Cabal-Prieto, Gabriela Teodoro-Bernabé, Cecilia Coria-Rincón, Lucia Sánchez-Arellano, Lorena Guadalupe Ramón-Canul, Jesús Rodríguez-Miranda, Witoon Prinyawiwatkul, José Manuel Juárez-Barrientos, José Andrés Herrera-Corredor, Emmanuel De Jesús Ramírez-Rivera Jan 2022

Development Of A Memories Vocabulary (Memvoc) For Food Products Using Coffee As Model, Adan Cabal-Prieto, Gabriela Teodoro-Bernabé, Cecilia Coria-Rincón, Lucia Sánchez-Arellano, Lorena Guadalupe Ramón-Canul, Jesús Rodríguez-Miranda, Witoon Prinyawiwatkul, José Manuel Juárez-Barrientos, José Andrés Herrera-Corredor, Emmanuel De Jesús Ramírez-Rivera

Faculty Publications

Multiple references in sensory science indicate that foods evoke memories during consumption, however, research regarding those memories is still limited. The objective of this study was to develop a vocabulary and implement it in a memories vocabulary related to food as a complement for the evaluation of sensory attributes and emotions, using coffee as a model. The memories vocabulary was generated with a series of successive studies that involved assigning positive and negative memories to different food groups and applying mathematical algorithms (WordCountAna and Factorial Approach) and contrasting memories with the scientific literature. Subsequently, the vocabulary was used to determine …

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Sensory Drivers Of Consumer Acceptance, Purchase Intent And Emotions Toward Brewed Black Coffee, Ammaraporn Pinsuwan, Suntaree Suwonsichon, Penkwan Chompreeda, Witoon Prinyawiwatkul Jan 2022

Sensory Drivers Of Consumer Acceptance, Purchase Intent And Emotions Toward Brewed Black Coffee, Ammaraporn Pinsuwan, Suntaree Suwonsichon, Penkwan Chompreeda, Witoon Prinyawiwatkul

Faculty Publications

The link between coffee aroma/flavor and elicited emotions remains underexplored. This research identified key sensory characteristics of brewed black coffee that affected acceptance, purchase intent and emotions for Thai consumers. Eight Arabica coffee samples were evaluated by eight trained descriptive panelists for intensities of 26 sensory attributes and by 100 brewed black coffee users for acceptance, purchase intent and emotions. Results showed that the samples exhibited a wide range of sensory characteristics, and large differences were mainly described by the attributes coffee identity (coffee ID), roasted, bitter taste, balance/blended and fullness. Differences also existed among the samples for overall liking, …

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No Guts About It: Captivity, But Not Neophobia Phenotype, Influences The Cloacal Microbiome Of House Sparrows (Passer Domesticus), T. R. Kelly, A. E. Vinson, G. M. King, C. R. Lattin Jan 2022

No Guts About It: Captivity, But Not Neophobia Phenotype, Influences The Cloacal Microbiome Of House Sparrows (Passer Domesticus), T. R. Kelly, A. E. Vinson, G. M. King, C. R. Lattin

Faculty Publications

Behavioral traits such as anxiety and depression have been linked to diversity of the gut microbiome in humans, domesticated animals, and lab-bred model species, but the extent to which this link exists in wild animals, and thus its eco- logical relevance, is poorly understood. We examined the relationship between a behavioral trait (neophobia) and the cloacal microbiome in wild house sparrows ( Passer domesticus, n = 22) to determine whether gut microbial diversity is related to per- sonality in a wild animal. We swabbed the cloaca immediately upon capture, assessed neophobia phenotypes in the lab, and then swabbed the cloaca …

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Adapting Ripple Effect Mapping To A Virtual Survey Format, Matthew D. Greene, Jessica Stroope, Denise Holston Jan 2022

Adapting Ripple Effect Mapping To A Virtual Survey Format, Matthew D. Greene, Jessica Stroope, Denise Holston

Faculty Publications

Community development projects continue despite the COVID-19 pandemic. Participatory evaluation of these projects is crucial. Ripple effect mapping (REM) is a participatory approach to evaluation that captures coalition and community member perspectives on program outcomes and impacts. In response to COVID-19, the Louisiana State University AgCenter Healthy Communities Initiative adapted REM for online delivery. The REM evaluation was found to be an effective way for community coalitions to reflect on outcomes and impacts and to motivate continued engagement

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Calorie Restriction Improves Lipid-Related Emerging Cardiometabolic Risk Factors In Healthy Adults Without Obesity: Distinct Influences Of Bmi And Sex From Calerie™ A Multicentre, Phase 2, Randomised Controlled Trial, Kim M. Huffman, Daniel C. Parker, Manjushri Bhapkar, Susan B. Racette, Corby K. Martin, Leanne M. Redman, Sai Krupa Das, Margery A. Connelly, Carl F. Pieper, Melissa Orenduff, Leanna M. Ross, Megan E. Ramaker, James L. Dorling, Clifford J. Rosen, Irina Shalaurova, James D. Otvos, Virginia B. Kraus, William E. Kraus Jan 2022

Calorie Restriction Improves Lipid-Related Emerging Cardiometabolic Risk Factors In Healthy Adults Without Obesity: Distinct Influences Of Bmi And Sex From Calerie™ A Multicentre, Phase 2, Randomised Controlled Trial, Kim M. Huffman, Daniel C. Parker, Manjushri Bhapkar, Susan B. Racette, Corby K. Martin, Leanne M. Redman, Sai Krupa Das, Margery A. Connelly, Carl F. Pieper, Melissa Orenduff, Leanna M. Ross, Megan E. Ramaker, James L. Dorling, Clifford J. Rosen, Irina Shalaurova, James D. Otvos, Virginia B. Kraus, William E. Kraus

Clinical Research Faculty Publications

Background: For many cardiovascular risk factors there is no lower limit to which further reduction will result in decreased disease risk; this includes values within ranges considered normal for healthy adults. This seems to be true for new emerging metabolic risk factors identified by innovative technological advances. Further, there seems to be ever evolving evidence of differential responses to lifestyle interventions by sex and body compositions in the normal range. In this secondary analysis, we had the opportunity to test these principles for newly identified molecular biomarkers of cardiometabolic risk in a young (21–50 years), normal weight healthy population undergoing …

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Maternal Mindful Eating As A Target For Improving Metabolic Outcomes In Pregnant Women With Obesity, Karen L. Lindsay, Jasper Most, Kerrie Buehler, Maryam Kebbe, Abby D. Altazan, Leanne M. Redman Dec 2021

Maternal Mindful Eating As A Target For Improving Metabolic Outcomes In Pregnant Women With Obesity, Karen L. Lindsay, Jasper Most, Kerrie Buehler, Maryam Kebbe, Abby D. Altazan, Leanne M. Redman

Clinical Research Faculty Publications

Background: Maternal diet and eating behaviors have the potential to influence the metabolic milieu in pregnancies complicated by obesity, with implications for the developmental programming of offspring obesity. Emerging evidence suggests that mindfulness during eating may influence metabolic health in non-pregnant populations, but its effects in the context of pregnancy is less well understood. This study explored the individual and combined effects of mindful eating and diet quality on metabolic outcomes among pregnant women with obesity. Methods: In 46 pregnant women (body mas index >30 kg/m2) enrolled in the MomEE observational study, mindful eating (Mindful Eating Questionnaire, MEQ) and energy-adjusted …

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Gut Microbiota Composition And Predicted Microbial Metabolic Pathways Of Obesity Prone And Obesity Resistant Outbred Sprague-Dawley Cd Rats May Account For Differences In Their Phenotype, Diana N. Obanda, Michael J. Keenan, Ryan Page, Anne M. Raggio, Christopher M. Taylor, Brian D. Marx, Rhett W. Stout, Justin Guice, Meng Luo, David A. Welsh, Diana Coulon, Claudia Husseneder Dec 2021

Gut Microbiota Composition And Predicted Microbial Metabolic Pathways Of Obesity Prone And Obesity Resistant Outbred Sprague-Dawley Cd Rats May Account For Differences In Their Phenotype, Diana N. Obanda, Michael J. Keenan, Ryan Page, Anne M. Raggio, Christopher M. Taylor, Brian D. Marx, Rhett W. Stout, Justin Guice, Meng Luo, David A. Welsh, Diana Coulon, Claudia Husseneder

Faculty Publications

Like humans, outbred Sprague-Dawley CD rats exhibit a polygenic pattern of inheritance of the obese phenotype and not all individuals exposed to a high calorie intake develop obesity. We hypothesized that differences in gut microbiota composition account for phenotype differences between obese prone (OP) and obese resistant (OR) rats. We studied the gut microbiota composition of OPand OR rats after a high fat (HF) diet and how they respond to fermentation of resistant starch (RS). In phase 1 of the study 28 OP and 28 OR rats were fed a HF diet. In order to determine causal role of microbiota …

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Hypothalamic Steroid Receptor Coactivator-2 Regulates Adaptations To Fasting And Overnutrition, Yongjie Yang, Yanlin He, Hailan Liu, Wenjun Zhou, Chunmei Wang, Pingwen Xu, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Makoto Fukuda, Qingchun Tong, Jianming Xu, Zheng Sun, Bert W. O'Malley, Yong Xu Dec 2021

Hypothalamic Steroid Receptor Coactivator-2 Regulates Adaptations To Fasting And Overnutrition, Yongjie Yang, Yanlin He, Hailan Liu, Wenjun Zhou, Chunmei Wang, Pingwen Xu, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Makoto Fukuda, Qingchun Tong, Jianming Xu, Zheng Sun, Bert W. O'Malley, Yong Xu

Division of Basic Science Faculty Publications

The neuroendocrine system coordinates metabolic and behavioral adaptations to fasting, including reducing energy expenditure, promoting counterregulation, and suppressing satiation and anxiety to engage refeeding. Here, we show that steroid receptor coactivator-2 (SRC-2) in pro-opiomelanocortin (POMC) neurons is a key regulator of all these responses to fasting. POMC-specific deletion of SRC-2 enhances the basal excitability of POMC neurons; mutant mice fail to efficiently suppress energy expenditure during food deprivation. SRC-2 deficiency blunts electric responses of POMC neurons to glucose fluctuations, causing impaired counterregulation. When food becomes available, these mutant mice show insufficient refeeding associated with enhanced satiation and discoordination of anxiety …

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Domoic Acid And Pseudo-Nitzschia Spp. Connected To Coastal Upwelling Along Coastal Inhambane Province, Mozambique: A New Area Of Concern, Holly Kelchner, Katie E. Reeve-Arnold, Kathryn M. Schreiner, Sibel Bargu, Kim G. Roques, Reagan M. Errera Dec 2021

Domoic Acid And Pseudo-Nitzschia Spp. Connected To Coastal Upwelling Along Coastal Inhambane Province, Mozambique: A New Area Of Concern, Holly Kelchner, Katie E. Reeve-Arnold, Kathryn M. Schreiner, Sibel Bargu, Kim G. Roques, Reagan M. Errera

Faculty Publications

Harmful algal blooms (HABs) are increasing globally in frequency, persistence, and geo-graphic extent, posing a threat to ecosystem and human health. To date, no occurrences of marine phycotoxins have been recorded in Mozambique, which may be due to absence of a monitoring program and general awareness of potential threats. This study is the first documentation of neurotoxin, domoic acid (DA), produced by the diatom Pseudo-nitzschia along the east coast of Africa. Coastal Inhambane Province is a biodiversity hotspot where year-round Rhincodon typus (whale shark) sightings are among the highest globally and support an emerging ecotourism industry. Links between primary productivity …

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5-Ht Recruits Distinct Neurocircuits To Inhibit Hunger-Driven And Non-Hunger-Driven Feeding, Yanlin He, Xing Cai, Hailan Liu, Krisitine M. Conde, Pingwen Xu, Yongxiang Li, Chunmei Wang, Meng Yu, Yang He, Hesong Liu, Chen Liang, Tingting Yang, Yongjie Yang, Kaifan Yu, Julia Wang, Rong Zheng, Feng Liu, Zheng Sun, Lora Heisler, Qi Wu, Qingchun Tong, Canjun Zhu, Gang Shu, Yong Xu Dec 2021

5-Ht Recruits Distinct Neurocircuits To Inhibit Hunger-Driven And Non-Hunger-Driven Feeding, Yanlin He, Xing Cai, Hailan Liu, Krisitine M. Conde, Pingwen Xu, Yongxiang Li, Chunmei Wang, Meng Yu, Yang He, Hesong Liu, Chen Liang, Tingting Yang, Yongjie Yang, Kaifan Yu, Julia Wang, Rong Zheng, Feng Liu, Zheng Sun, Lora Heisler, Qi Wu, Qingchun Tong, Canjun Zhu, Gang Shu, Yong Xu

Division of Basic Science Faculty Publications

Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HTDRN) regulate different types of feeding behavior, such as eating to cope with hunger or for pleasure. Here, we observed that activation of 5-HTDRN to hypothalamic arcuate nucleus (5-HTDRN → ARH) projections inhibits food intake driven by hunger via actions at ARH 5-HT2C and 5-HT1B receptors, whereas activation of 5-HTDRN to ventral tegmental area (5-HTDRN → VTA) projections inhibits non-hunger-driven feeding via actions at 5-HT2C receptors. Further, hunger-driven feeding gradually activates ARH-projecting 5-HTDRN …

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Genomics And Transcriptomics Landscapes Associated To Changes In Insulin Sensitivity In Response To Endurance Exercise Training, Louise Y. Takeshita, Peter K. Davidsen, John M. Herbert, Philipp Antczak, Matthijs K.C. Hesselink, Patrick Schrauwen, S. John Weisnagel, Jeremy M. Robbins, Robert E. Gerszten, Sujoy Ghosh, Mark A. Sarzynski, Claude Bouchard, Francesco Falciani Dec 2021

Genomics And Transcriptomics Landscapes Associated To Changes In Insulin Sensitivity In Response To Endurance Exercise Training, Louise Y. Takeshita, Peter K. Davidsen, John M. Herbert, Philipp Antczak, Matthijs K.C. Hesselink, Patrick Schrauwen, S. John Weisnagel, Jeremy M. Robbins, Robert E. Gerszten, Sujoy Ghosh, Mark A. Sarzynski, Claude Bouchard, Francesco Falciani

Division of Basic Science Faculty Publications

Despite good adherence to supervised endurance exercise training (EET), some individuals experience no or little improvement in peripheral insulin sensitivity. The genetic and molecular mechanisms underlying this phenomenon are currently not understood. By investigating genome-wide variants associated with baseline and exercise-induced changes (∆) in insulin sensitivity index (Si) in healthy volunteers, we have identified novel candidate genes whose mouse knockouts phenotypes were consistent with a causative effect on Si. An integrative analysis of functional genomic and transcriptomic profiles suggests genetic variants have an aggregate effect on baseline Si and ∆Si, focused around cholinergic signalling, including downstream calcium and chemokine signalling. …

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Behavioral Characteristics And Self-Reported Health Status Among 2029 Adults Consuming A "Carnivore Diet", Belinda S. Lennerz, Jacob T. Mey, Owen H. Henn, David S. Ludwig Dec 2021

Behavioral Characteristics And Self-Reported Health Status Among 2029 Adults Consuming A "Carnivore Diet", Belinda S. Lennerz, Jacob T. Mey, Owen H. Henn, David S. Ludwig

Division of Basic Science Faculty Publications

Background: The "carnivore diet,"based on animal foods and excluding most or all plant foods, has attracted recent popular attention. However, little is known about the health effects and tolerability of this diet, and concerns for nutrient deficiencies and cardiovascular disease risk have been raised. Objectives: We obtained descriptive data on the nutritional practices and health status of a large group of carnivore diet consumers. Methods: A social media survey was conducted 30 March-24 June, 2020 among adults self-identifying as consuming a carnivore diet for ≥6 mo. Survey questions interrogated motivation, dietary intake patterns, symptoms suggestive of nutritional deficiencies or other …

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Functional Anatomy Of The Vagus System – Emphasis On The Somato-Visceral Interface, Winfried L. Neuhuber, Hans Rudolf Berthoud Dec 2021

Functional Anatomy Of The Vagus System – Emphasis On The Somato-Visceral Interface, Winfried L. Neuhuber, Hans Rudolf Berthoud

Division of Basic Science Faculty Publications

Due to its pivotal role in autonomic networks, the vagus attracts continuous interest from both basic scientists and clinicians. In particular, recent advances in vagus nerve stimulation strategies and their application to pathological conditions beyond epilepsy provide a good opportunity to recall basic features of vagal peripheral and central anatomy. In addition to the “classical” vagal brainstem nuclei, i.e., dorsal motor nucleus, nucleus ambiguus and nucleus tractus solitarii, the spinal trigeminal and paratrigeminal nuclei come into play as targets of vagal afferents. On the other hand, the nucleus of the solitary tract receives and integrates not only visceral but also …

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Deciphering An Agrp-Serotoninergic Neural Circuit In Distinct Control Of Energy Metabolism From Feeding, Yong Han, Guobin Xia, Dollada Srisai, Fantao Meng, Yanlin He, Yali Ran, Yang He, Monica Farias, Giang Hoang, István Tóth, Marcelo O. Dietrich, Miao Hsueh Chen, Yong Xu, Qi Wu Dec 2021

Deciphering An Agrp-Serotoninergic Neural Circuit In Distinct Control Of Energy Metabolism From Feeding, Yong Han, Guobin Xia, Dollada Srisai, Fantao Meng, Yanlin He, Yali Ran, Yang He, Monica Farias, Giang Hoang, István Tóth, Marcelo O. Dietrich, Miao Hsueh Chen, Yong Xu, Qi Wu

Division of Basic Science Faculty Publications

Contrasting to the established role of the hypothalamic agouti-related protein (AgRP) neurons in feeding regulation, the neural circuit and signaling mechanisms by which they control energy expenditure remains unclear. Here, we report that energy expenditure is regulated by a subgroup of AgRP neurons that send non-collateral projections to neurons within the dorsal lateral part of dorsal raphe nucleus (dlDRN) expressing the melanocortin 4 receptor (MC4R), which in turn innervate nearby serotonergic (5-HT) neurons. Genetic manipulations reveal a bi-directional control of energy expenditure by this circuit without affecting food intake. Fiber photometry and electrophysiological results indicate that the thermo-sensing MC4RdlDRN neurons …

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A Randomized Clinical Trial On The Effects Of Exercise On Muscle Remodelling Following Bariatric Surgery, Saulo Gil, John P. Kirwan, Igor H. Murai, Wagner S. Dantas, Carlos Alberto Abujabra Merege-Filho, Sujoy Ghosh, Samuel K. Shinjo, Rosa M.R. Pereira, Walcy R. Teodoro, Sheylla M. Felau, Fabiana B. Benatti, Ana L. De Sá-Pinto, Fernanda Lima, Roberto De Cleva, Marco Aurélio Santo, Bruno Gualano, Hamilton Roschel Dec 2021

A Randomized Clinical Trial On The Effects Of Exercise On Muscle Remodelling Following Bariatric Surgery, Saulo Gil, John P. Kirwan, Igor H. Murai, Wagner S. Dantas, Carlos Alberto Abujabra Merege-Filho, Sujoy Ghosh, Samuel K. Shinjo, Rosa M.R. Pereira, Walcy R. Teodoro, Sheylla M. Felau, Fabiana B. Benatti, Ana L. De Sá-Pinto, Fernanda Lima, Roberto De Cleva, Marco Aurélio Santo, Bruno Gualano, Hamilton Roschel

Division of Basic Science Faculty Publications

Background: Muscle atrophy and strength loss are common adverse outcomes following bariatric surgery. This randomized, controlled trial investigated the effects of exercise training on bariatric surgery-induced loss of muscle mass and function. Additionally, we investigated the effects of the intervention on molecular and histological mediators of muscle remodelling. Methods: Eighty women with obesity were randomly assigned to a Roux-en-Y gastric bypass (RYGB: n = 40, age = 42 ± 8 years) or RYGB plus exercise training group (RYGB + ET: n = 40, age = 38 ± 7 years). Clinical and laboratory parameters were assessed at baseline, and 3 (POST3) …

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Overfeeding-Induced Weight Gain Elicits Decreases In Sex Hormone-Binding Globulin In Healthy Males—Implications For Body Fat Distribution, Prachi Singh, Naima Covassin, Fatima H. Sert-Kuniyoshi, Kara L. Marlatt, Abel Romero-Corral, Diane E. Davison, Ravinder J. Singh, Michael D. Jensen, Virend K. Somers Dec 2021

Overfeeding-Induced Weight Gain Elicits Decreases In Sex Hormone-Binding Globulin In Healthy Males—Implications For Body Fat Distribution, Prachi Singh, Naima Covassin, Fatima H. Sert-Kuniyoshi, Kara L. Marlatt, Abel Romero-Corral, Diane E. Davison, Ravinder J. Singh, Michael D. Jensen, Virend K. Somers

Clinical Research Faculty Publications

Objective: Obesity and upper-body fat elevates cardiometabolic risk. However, mechanisms predisposing to upper-body fat accumulation are not completely understood. In males, low testosterone (T) frequently associates with obesity, and estrogen deficiency may contribute to upper-body adiposity. This study examines the effects of overfeeding-induced weight gain on changes in gonadal hormones in healthy males and its association with regional fat depots. Methods: Twenty-five males (age: 29.7 ± 6.9 years; BMI: 24.7 ± 3.1 kg/m2) were overfed for 8 weeks to gain approximately 5% body weight. Changes in total and regional fat depots were assessed using dual-energy x-ray absorptiometry and abdominal computed …

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Obesity And Cancer Death In White And Black Adults: A Prospective Cohort Study, Justin C. Brown, Shengping Yang, Emily F. Mire, Xiaocheng Wu, Lucio Miele, Augusto Ochoa, Jovanny Zabaleta, Peter T. Katzmarzyk Dec 2021

Obesity And Cancer Death In White And Black Adults: A Prospective Cohort Study, Justin C. Brown, Shengping Yang, Emily F. Mire, Xiaocheng Wu, Lucio Miele, Augusto Ochoa, Jovanny Zabaleta, Peter T. Katzmarzyk

Population and Public Health Science Faculty Publications

Objective: This study aimed to determine whether race modifies the association between obesity and cancer death. Methods: The Pennington Center Longitudinal Study included 18,296 adults; 35.0% were male and 34.3% were Black. The primary end point was death from cancer. Results: During a follow-up of 14.3 years, 346 cancer deaths occurred. Among men, race modified the association of BMI and cancer death (pinteraction = 0.045); compared with a BMI of 22 kg/m2, a BMI of 35 in White men was associated with a hazard ratio of 1.74 (95% CI: 1.38-2.21), and in Black men, the hazard ratio was …

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Biological And Environmental Influences On Motor Coordination In Peruvian Children And Adolescents, Sara Pereira, Alcibíades Bustamante, Carla Santos, Donald Hedeker, Go Tani, Rui Garganta, Olga Vasconcelos, Adam Baxter-Jones, Peter T. Katzmarzyk, José Maia Dec 2021

Biological And Environmental Influences On Motor Coordination In Peruvian Children And Adolescents, Sara Pereira, Alcibíades Bustamante, Carla Santos, Donald Hedeker, Go Tani, Rui Garganta, Olga Vasconcelos, Adam Baxter-Jones, Peter T. Katzmarzyk, José Maia

Population and Public Health Science Faculty Publications

This study investigated the associations between biological and environmental factors and gross-motor coordination (GMC) in Peruvian children and adolescents. The sample comprised 7401 boys and girls, aged 6–14 years, recruited from three geographical regions: sea-level, Amazon and high-altitude. Biological variables included age, sex, height, BMI, physical fitness, stunting, and maturational status. Environmental influences included geographical region and school characteristics. Gross-motor coordination was tested with the Körperkoordinationstest für Kinder and the data analyzed by multilevel logistic regression. Results showed a high prevalence of below normal GMC scores. Sex, age, geographical area, biological maturation, BMI (normal versus overweight/obesity), and stunting were all …

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The Acute Transcriptional Responses To Dietary Methionine Restriction Are Triggered By Inhibition Of Ternary Complex Formation And Linked To Erk1/2, Mtor, And Atf4, Kirsten P. Stone, Sujoy Ghosh, Jean Paul Kovalik, Manda Orgeron, Desiree Wanders, Landon C. Sims, Thomas W. Gettys Dec 2021

The Acute Transcriptional Responses To Dietary Methionine Restriction Are Triggered By Inhibition Of Ternary Complex Formation And Linked To Erk1/2, Mtor, And Atf4, Kirsten P. Stone, Sujoy Ghosh, Jean Paul Kovalik, Manda Orgeron, Desiree Wanders, Landon C. Sims, Thomas W. Gettys

Division of Basic Science Faculty Publications

The initial sensing of dietary methionine restriction (MR) occurs in the liver where it activates an integrated stress response (ISR) that quickly reduces methionine utilization. The ISR program is regulated in part by ATF4, but ATF4’s prototypical upstream regulator, eIF2α, is not acutely activated by MR. Bioinformatic analysis of RNAseq and metabolomics data from liver samples harvested 3 h and 6 h after initiating MR shows that general translation is inhibited at the level of ternary complex formation by an acute 50% reduction of hepatic methionine that limits formation of initiator methionine tRNA. The resulting ISR is induced by selective …

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Nt-Pgc-1Α Deficiency Attenuates High-Fat Diet-Induced Obesity By Modulating Food Intake, Fecal Fat Excretion And Intestinal Fat Absorption, Jihyun Kim, Jiyoung Moon, Chul Hong Park, Jisu Lee, Helia Cheng, Z. Elizabeth Floyd, Ji Suk Chang Dec 2021

Nt-Pgc-1Α Deficiency Attenuates High-Fat Diet-Induced Obesity By Modulating Food Intake, Fecal Fat Excretion And Intestinal Fat Absorption, Jihyun Kim, Jiyoung Moon, Chul Hong Park, Jisu Lee, Helia Cheng, Z. Elizabeth Floyd, Ji Suk Chang

Division of Basic Science Faculty Publications

Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α regulate metabolic adaptation by modulating many gene programs. Selective ablation of PGC-1α attenuates diet-induced obesity through enhancing fatty acid oxidation and thermogenesis by upregulation of NT-PGC-1α in brown adipose tissue (BAT). Recently, we have shown that selective ablation of NT-PGC-1α reduces fatty acid oxidation in BAT. Thus, the objective of this study was to test our hypothesis that NT-PGC-1α−/− mice would be more prone to diet-induced obesity. Male and female NT-PGC-1α+/+ (WT) and NT-PGC-1α−/− mice were fed a regular chow or 60% high-fat (HF) diet for 16 weeks. Contrary to our expectations, …

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Ale Beer Containing Free And Immobilized Lactobacillus Brevis, A Potential Delivery System For Probiotics, Kriza Faye Calumba, Vondel Reyes, Franklin Bonilla, Elio Villasmil, Subramaniam Sathivel Dec 2021

Ale Beer Containing Free And Immobilized Lactobacillus Brevis, A Potential Delivery System For Probiotics, Kriza Faye Calumba, Vondel Reyes, Franklin Bonilla, Elio Villasmil, Subramaniam Sathivel

Faculty Publications

Abstract: Probiotics in ale beer may be attractive to health-conscious consumers. However, beer conditions may decrease probiotic viability. Powder produced from durian (Durio zibethinus) rind, a by-product that is currently unutilized, can be used for the immobilization of probiotics. MRS medium was incubated with Lactobacillus brevis and periodically sampled to obtain the growth curve. Ale beer with free L. brevis and cells immobilized in durian rind powder was produced and separately assessed during storage at 21 °C for 24 days. The physico-chemical parameters of both beers did not differ significantly. Durian rind powder conferred protection up to 12 days of …

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Household Chaos, Family Routines, And Young Child Movement Behaviors In The U.S. During The Covid-19 Outbreak: A Cross-Sectional Study, Chelsea L. Kracht, Peter T. Katzmarzyk, Amanda E. Staiano Dec 2021

Household Chaos, Family Routines, And Young Child Movement Behaviors In The U.S. During The Covid-19 Outbreak: A Cross-Sectional Study, Chelsea L. Kracht, Peter T. Katzmarzyk, Amanda E. Staiano

Population and Public Health Science Faculty Publications

Background: The home environment is an important facilitator of young child movement behaviors, including physical activity (PA), sleep, and screen-time. Household chaos, characterized by crowding, noise, and disorder in the home, may hinder efforts to obtain adequate amounts of movement behaviors. The COVID-19 outbreak impacted many families, and social distancing during this time may create conditions for more household chaos. Family routines can help establish order in the home and encourage an appropriate balance of movement behaviors, such as less screen-time and more sleep. The purpose of this study was to evaluate the association between household chaos and young child …

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Adolescents’ Sedentary Time, Affect, And Contextual Factors: An Ecological Momentary Assessment Study, Chelsea L. Kracht, Robbie A. Beyl, Jaclyn P. Maher, Peter T. Katzmarzyk, Amanda E. Staiano Dec 2021

Adolescents’ Sedentary Time, Affect, And Contextual Factors: An Ecological Momentary Assessment Study, Chelsea L. Kracht, Robbie A. Beyl, Jaclyn P. Maher, Peter T. Katzmarzyk, Amanda E. Staiano

Population and Public Health Science Faculty Publications

Background: Few adolescents achieve sufficient levels of physical activity, and many are spending most of their time in sedentary behavior. Affective response following sedentary time may influence motivation to remain sedentary. Ecological Momentary Assessment (EMA) is a real-time data capture methodology that can be used to identify factors influencing sedentary time, such as the context of the home setting, and resulting affective state within a free-living setting. The purpose of this study was to evaluate the relationship between context at home and adolescent sedentary time, and the relationship of sedentary time and subsequent affect. Methods: Adolescents (n = 284; 10–16 …

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E-&Mhealth Interventions Targeting Nutrition, Physical Activity, Sedentary Behavior, And/Or Obesity Among Children: A Scoping Review Of Systematic Reviews And Meta-Analyses, Chelsea L. Kracht, Melinda Hutchesson, Mavra Ahmed, Andre Matthias Müller, Lee M. Ashton, Hannah M. Brown, Ann Desmet, Carol A. Maher, Chelsea E. Mauch, Corneel Vandelanotte, Zenong Yin, Megan Whatnall, Camille E. Short, Amanda E. Staiano Dec 2021

E-&Mhealth Interventions Targeting Nutrition, Physical Activity, Sedentary Behavior, And/Or Obesity Among Children: A Scoping Review Of Systematic Reviews And Meta-Analyses, Chelsea L. Kracht, Melinda Hutchesson, Mavra Ahmed, Andre Matthias Müller, Lee M. Ashton, Hannah M. Brown, Ann Desmet, Carol A. Maher, Chelsea E. Mauch, Corneel Vandelanotte, Zenong Yin, Megan Whatnall, Camille E. Short, Amanda E. Staiano

Population and Public Health Science Faculty Publications

Childhood obesity is a public health concern. Electronic and mobile health (e-&mHealth) approaches can facilitate the delivery of interventions for obesity prevention and treatment. Synthesizing reviews of e-&mHealth interventions to improve weight and weight-related behaviors (physical activity, sedentary behavior, and diet) is useful to characterize the current scope of the literature and identify opportunities for future reviews and studies. Using a scoping review methodology, we aimed to evaluate the breadth and methodological quality of systematic reviews and meta-analyses of e-&mHealth interventions targeting weight and weight-related behaviors in children and adolescents aged < 19 years. A systematic search of seven databases was conducted, including reviews published between 2000 and 2019. Review characteristics were extracted, and methodological quality was assessed using the AMSTAR 2 tool. Forty-five systematic reviews and meta-analyses were included. All reviews evaluated intervention efficacy (100%), but few assessed other aspects (20% in total) such as cost-effectiveness. Smartphone applications (47%), text messages (44%), and websites (35%) were the main modalities. Weight (60%), physical activity (51%), and diet (44%) were frequently assessed, unlike sedentary behavior (8%). Most reviews were rated as having critically low or low methodological quality (97%). Reviews that identify the effective active ingredients of interventions and explore metrics beyond efficacy are recommended.

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Psychometric Properties Of The Contextual Body Image Questionnaire For Athletes: A Replication And Extension Study In Female Collegiate Athletes, Tiffany Stewart, Lisa Kilpela, Nicole Wesley, Kate Baule, Carolyn Becker Dec 2021

Psychometric Properties Of The Contextual Body Image Questionnaire For Athletes: A Replication And Extension Study In Female Collegiate Athletes, Tiffany Stewart, Lisa Kilpela, Nicole Wesley, Kate Baule, Carolyn Becker

Population and Public Health Science Faculty Publications

Background: Although the link between body dissatisfaction and eating disorder (ED) pathology is well-established in general female samples, less is known about contextual body image (CBI) among female athletes. CBI refers to female athletes’ body image concerns in two contexts: sport and daily life. The Contextual Body Image Questionnaire for Athletes (CBIQA) measures four dimensions of body image (Appearance, Thin-Fat Self-Evaluation, Thin-Fat Others’ Evaluation, and Muscularity) in both contexts. In a sample of female collegiate athletes, this study sought to A) investigate the psychometric properties of the CBIQA, B) examine the cross-sectional relation of CBI with ED pathology and negative …

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Patient-Specific Factors Associated With Use Of Diabetes Self-Management Education And Support Programs In Louisiana, Yilin Yoshida, Dongzhe Hong, Elizabeth Nauman, Eboni G. Price-Haywood, Alessandra N. Bazzano, Charles Stoecker, Gang Hu, Yun Shen, Peter T. Katzmarzyk, Vivian A. Fonseca, Lizheng Shi Dec 2021

Patient-Specific Factors Associated With Use Of Diabetes Self-Management Education And Support Programs In Louisiana, Yilin Yoshida, Dongzhe Hong, Elizabeth Nauman, Eboni G. Price-Haywood, Alessandra N. Bazzano, Charles Stoecker, Gang Hu, Yun Shen, Peter T. Katzmarzyk, Vivian A. Fonseca, Lizheng Shi

Population and Public Health Science Faculty Publications

Introduction The prevalence of diabetes self-management education and support (DSME/S) use among patients with newly diagnosed type 2 diabetes mellitus (T2DM) and patients with insulin prescription has not been evaluated. It is also unclear what demographic, behavioral, and clinical factors associated with use of DSME/S. Research design and methods This retrospective analysis was based on electronic health records from the Research Action for Health Network (2013-2019). Patients with newly diagnosed T2DM were identified as 35-94 year-olds diagnosed with T2DM≥1 year after the first recorded office visit. Patients with insulin were identified by the first insulin prescription records. DSME/S (Healthcare Common …

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