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The Effects Of Chemical Reagents And Physical Environment On The In Vitro And In Vivo Properties Of Adipose-Derived Multipotent Stromal Cells Isolated From Different Species, Wei Duan Jan 2017

The Effects Of Chemical Reagents And Physical Environment On The In Vitro And In Vivo Properties Of Adipose-Derived Multipotent Stromal Cells Isolated From Different Species, Wei Duan

LSU Doctoral Dissertations

Adult adipose derived mesenchymal stromal cells (ASCs) have been characterized in various species. Many factors may affect ASC fate and ASCs from different species may have different response to these factors. The first study was to identify the differences of the canine ASCs isolated from subcutaneous and infrapatellar adipose tissues, and evaluate the impact of cryopreservation on the cells. Based on paired comparisons of fresh and cryopreserved ASCs, cryopreserved ASCs had lower CD29 and CD44 protein expression and lower proliferation rates. The cryopreserved ASCs had relative lower mitochondria in the cytoplasm compared to the fresh ASCs regardless of tissue sources. …


Fibroblast Growth Factor 21 Is A Novel Protein Sensor In Pregnancy, Elizabeth Frost Sutton Jan 2017

Fibroblast Growth Factor 21 Is A Novel Protein Sensor In Pregnancy, Elizabeth Frost Sutton

LSU Doctoral Dissertations

The twenty-first century has experienced a shift in cause of death worldwide from communicable diseases to noncommunicable diseases. Interestingly, many of these implicated chronic diseases, such as cancer, diabetes, and cardiovascular disease, have been shown to be programmed in the womb. As first posited by the Barker Hypothesis, adverse exposures in utero can increase an individual’s risk for chronic disease later in life. Therefore, pregnancy is an opportune time for intervention to improve the health of future generations. Studies of exposures known to negatively impact infant health, e.g. states of overnutrition (obesity, diabetes, excess gestational weight gain) and undernutrition (starvation, …


Human Gut Microbiota And Obesity: How Is Gut Microbiota Associated With Obesity Improvement Induced By Bariatric Surgeries Or Low-Calorie Diet Treatment?, Rui Zhang Jan 2017

Human Gut Microbiota And Obesity: How Is Gut Microbiota Associated With Obesity Improvement Induced By Bariatric Surgeries Or Low-Calorie Diet Treatment?, Rui Zhang

LSU Doctoral Dissertations

An increasing number of studies suggest that the complex microbial community of the human gut may have an important role in human health and disease conditions such as obesity and diabetes. However, the causal relationship among gut microbiota, obesity, weight loss, and the influence of bariatric surgery remains largely unknown. This study investigated the correlation between human gut microbiota and obesity via determining how gut microbiota is associated with obesity improvement induced by bariatric surgeries (BRS) and low-calorie diet (LCD) treatment. Specifically, we investigated the effects of various bariatric surgery (BRS) procedures and a low-calorie diet (LCD) treatment on the …


The Fooding Of Narrative In Contemporary Women's Transnational Fiction, Stacey Marie Amo Jan 2017

The Fooding Of Narrative In Contemporary Women's Transnational Fiction, Stacey Marie Amo

LSU Doctoral Dissertations

The Fooding of Narrative in Contemporary Women’s Transnational Fiction examines how foodstuffs are strategically deployed in recent fiction about migration to the United States. The novels examined, all set in the period following the passage of the Immigration and Nationality Act of 1965, depict the experience of resettlement from a diverse set of postcolonial sites: Haiti, Cuba, Vietnam, and India. The Fooding of Narrative argues that food is deployed as a structuring trope and acquires narrative significance in articulating the profound sense of identity crisis that frequently accompanies the immigration experience. By focusing on food’s narrative significance in a broad …


Determining The Influence Of Imidacloprid And Glufosinate Ammonium On The Population Dynamics Of Twospotted Spider Mite Populations In Louisiana Cotton, Sebe Anthony Brown Jan 2017

Determining The Influence Of Imidacloprid And Glufosinate Ammonium On The Population Dynamics Of Twospotted Spider Mite Populations In Louisiana Cotton, Sebe Anthony Brown

LSU Doctoral Dissertations

Twospotted spider mites, Tetranychus urticae, is an important agricultural pest of many field crops worldwide. This study investigated the impacts of imidacloprid seed treatments on populations of twospotted spider mites while also investigating if exogenous applications of jasmonic acid can offset any hormone modulating effects caused by seed treatments. Imidacloprid seed treatments significantly increased cumulative adult mite days in 2013 but not 2015 or 2016 in the field. Applications of 10 millimolar jasmonic acid did not reduce mite severity or injury in all field trials. Imidacloprid seed treatments significantly increased all spider mite life stages in the laboratory while applications …


Examining The Impact Of Participating In A Nutrition-Education And Culinary Skills-Building Program On Intrinsic Motivation To Prepare Healthy Foods And Diet Quality In High School Adolescents, Derek Charles Miketinas Jan 2017

Examining The Impact Of Participating In A Nutrition-Education And Culinary Skills-Building Program On Intrinsic Motivation To Prepare Healthy Foods And Diet Quality In High School Adolescents, Derek Charles Miketinas

LSU Doctoral Dissertations

The objective of these studies was to develop a questionnaire that could measure the psychosocial constructs identified by the Self Determination Theory (SDT) as they relate to adolescents’ food preparation attitudes and their learning environment. The questionnaire included items that measured intrinsic motivation (IM), perceived competence (PC), relatedness, autonomy, and autonomy support. These studies explored the questionnaire’s validity, reliability, and ability to measure construct changes. The Adolescent Motivation to Cook Questionnaire (AMCQ) was developed in the first study to measure high school students’ IM and PC to prepare healthy foods, and their relatedness, autonomy and autonomy support within the classroom. …


Condition Of Birds In Amazonian Rainforest Fragments And Second-Growth Forests, Angelica Maria Hernandez Palma Jan 2017

Condition Of Birds In Amazonian Rainforest Fragments And Second-Growth Forests, Angelica Maria Hernandez Palma

LSU Doctoral Dissertations

Deforestation modifies otherwise intact expanses of forest into small, isolated fragments. In addition to fragmentation, deforestation also creates abrupt forest edges and large areas of regenerating vegetation where land is abandoned after clearing. Understanding how changes in the landscape affect the physical condition of birds is crucial for managing populations in human-modified landscapes. Here I use the biomarkers feather growth rate and feather quality (ptilochronology), fluctuating asymmetry (FA), and stress hormones from feathers (CORT), to estimate the physical condition of Amazonian understory birds living in forest fragments, second-growth forests, and continuous forests. Feather CORT revealed how fragmentation disrupts interspecific interactions; …


Social Work Practitioners Working In End Of Life Care:Learning To Provide Culturally Appropriate Care To Clients Of Middle Eastern Descent, Laura Shafica Meiki Jan 2017

Social Work Practitioners Working In End Of Life Care:Learning To Provide Culturally Appropriate Care To Clients Of Middle Eastern Descent, Laura Shafica Meiki

LSU Doctoral Dissertations

This study utilized an interpretive qualitative methodological approach to learn about the experiences of individuals with a Master of Social Work degree (MSWs) working in end-of-life (EOL) care with patients of Middle Eastern descent and their families. Specifically, it examined (1) how a sample of social workers obtained the skills necessary to provide culturally appropriate EOL care to clients and families of Middle Eastern descent; (2) the common intervention strategies social workers employ while providing this care; and (3) the recommendations they offer to others who anticipate encountering this population in their own practice. Data collection consisted of in-depth, semi-structured …


Documentation Of Siderophore Activity, Metal Binding, And Its Effect On Symptomatology Of Cercospora Leaf Blight Caused In Soybean By Cercosporin From Cercospora Cf. Flagellaris, Brian Michael Ward Jan 2017

Documentation Of Siderophore Activity, Metal Binding, And Its Effect On Symptomatology Of Cercospora Leaf Blight Caused In Soybean By Cercosporin From Cercospora Cf. Flagellaris, Brian Michael Ward

LSU Doctoral Dissertations

Cercospora leaf blight of soybean (Glycine max) is a serious problem in the mid-south of the United States and is present in most soybean-growing regions of the world. The causal organisms, Cercospora kikuchii, C. cf. flagellaris and C. cf. sigesbeckiae, utilize the photo-activated toxin cercosporin as the primary pathogenicity factor. The disease has historically been understood to progress from a purpling or bronzing of the leaves to a blight in which tissue dies. Previous literature showed possible binding of cercosporin to metals and previous work in our group showed possible use of minor element nutrition in the plant to reduce …


Branch And Stem Growth As Affected By Loss Of Leaf Area On Selected Branches In Loblolly Pine, Shannon Dumo Kidombo Jan 2017

Branch And Stem Growth As Affected By Loss Of Leaf Area On Selected Branches In Loblolly Pine, Shannon Dumo Kidombo

LSU Doctoral Dissertations

Leaf area and crown dynamics control how trees grow through their supply of carbohydrates and growth regulators, and their influence on tree mechanical stability. The influence of leaf area and crown dynamics to tree growth was investigated by testing the interdependence between leaf area, branch, and stem growth on young loblolly pine trees. The objectives were to (1) determine the influence of current and previous year’s leaf area on elongation of branches; (2) describe and test a unique way of quantitatively measuring the effect of neighbor branches on net growth of a target branch; (3) quantify the growth impact of …


Evaluation Of Control Tactics For Management Of Sweetpotato Weevil (Coleoptera: Curculionidae), Jie Chen Jan 2017

Evaluation Of Control Tactics For Management Of Sweetpotato Weevil (Coleoptera: Curculionidae), Jie Chen

LSU Doctoral Dissertations

Sweetpotato weevil (SPW), Cylas formicarius elegantulus (Summer), is the most damaging root-feeding insect of sweetpotato, Ipomoea batatas L. (Lam), worldwide. The efficacy and compatibility of host plant resistance and insecticide control were evaluated in this dissertation. cv. Beauregard is the most susceptible cultivar for oviposition and offspring performance of SPW compared to cvs. Evangeline and Murasaki. The oviposition preference was shaped by the larval experience of SPW, providing evidence in support of the Hopkins’ Host-Plant Selection Principle. Although oviposition on cv. Murasaki was reduced, the egg capacity of SPW developed on cv. Murasaki was not decreased, indicating an adaptive behavior …


Maternal Fatty Acid And Inflammatory Status During Pregnancy Are Related To Infant Heart Rate And Heart Rate Variability, Merritt Leanne Drewery Jan 2017

Maternal Fatty Acid And Inflammatory Status During Pregnancy Are Related To Infant Heart Rate And Heart Rate Variability, Merritt Leanne Drewery

LSU Doctoral Dissertations

Early life heart rate (HR) and heart rate variability (HRV) reflect autonomic maturation. Intervention with n-3 long chain polyunsaturated fatty acids (LCPUFAs) during pregnancy favorably affects fetal HR and HRV; similar observations have been reported with infant n-3 LCPUFA intake. Infant HR and HRV have not been assessed in relation to maternal fatty acid status during pregnancy. Further, exposure to intrauterine inflammation may underlie these observations, although this hypothesis has not been tested. The aim of this observational study was to explore associations between maternal fatty acid and inflammatory status during pregnancy and infant HR and HRV. Simple linear and …


Evolutionary Interactions Of Feather Molt In Birds, Ryan Scott Terrill Jan 2017

Evolutionary Interactions Of Feather Molt In Birds, Ryan Scott Terrill

LSU Doctoral Dissertations

The evolution of feathers was a key innovation for birds. The many functions that feathers provide have allowed birds to diversify into myriad habitats and styles of life. However, feathers are lightweight and break down, and must be replaced regularly in a process known as molt. The patterns and timing with which birds molt varies within and between species, and these different strategies are likely a product of the different ways birds use their feathers and the uneven distribution of resources available for molt in time and space. So far, no studies have attempted to place these strategies into an …


Evaluation Of Estrous Response Patches As A Tool To Determine Optimum Timing For Artificial Insemination And If Gonadotropin-Releasing Hormone Is Needed At Timed-Ai In Beef Cattle, Danilo Demeterco Jan 2017

Evaluation Of Estrous Response Patches As A Tool To Determine Optimum Timing For Artificial Insemination And If Gonadotropin-Releasing Hormone Is Needed At Timed-Ai In Beef Cattle, Danilo Demeterco

LSU Master's Theses

Two experiments evaluated using an estrous-detection patch to identify animals that are in standing estrus at split-timed AI (STAI) and the necessity of a gonadotropin-releasing hormone (GnRH) injection at STAI on a 7-Day CO-Synch + CIDR protocol. In experiment 1 (n=216) and in experiment 2 (n=101), multiparous lactating crossbred beef cows were stratified by age, BW, BCS, and post-partum interval to 2 treatment groups: CTRL=timed-AI (TAI) at 72h post CIDR removal, or TRT=STAI at 72 or 84h post CIDR removal. All females received GnRH plus a CIDR on d0, prostaglandin-F2α, CIDR removal, and an Estrotect estrous-detector patch on d7. At …


Molecular Genetics Of Cold Tolerance At Germination And Seedling Stages In Rice, Anna Hissahe Borjas Artica Jan 2017

Molecular Genetics Of Cold Tolerance At Germination And Seedling Stages In Rice, Anna Hissahe Borjas Artica

LSU Master's Theses

Low temperature stress is a major constraint for rice production in temperate and high altitude areas of the world. Delayed germination coupled with reduced seedling vigor hinders crop establishment and crop growth resulting in reduced rice productivity. Mapping of chromosomal regions controlling cold tolerance will accelerate marker-assisted breeding of cold tolerant rice varieties. A recombinant inbred line (RIL) mapping population involving a rice cultivar ‘Bengal’ and a US weedy rice accession ‘PSRR-1’ was evaluated for cold tolerance at both germination and seedling stages. Observations on germinating ability and seedling vigor were recorded under both low temperature (13oC) and optimum temperature …


Improving Nitrogen Use Efficiency And Yield In Louisiana Sugarcane Production Systems, Daniel Ernesto Forestieri Jan 2017

Improving Nitrogen Use Efficiency And Yield In Louisiana Sugarcane Production Systems, Daniel Ernesto Forestieri

LSU Master's Theses

Proper nitrogen (N) management is essential to optimize crop production. This study was conducted to evaluate different N fertilizer management strategies to improve N use efficiency and yield in sugarcane production in Louisiana. This research was initiated in 2013 at the Sugar Research Station in St. Gabriel, LA and was arranged in a randomized complete block design with four replications consisting of different N rates (0, 45, 90, and 135 kg N ha-1) and sources (urea-46% N, ammonium nitrate [AN]-34% N, and urea-ammonium-nitrate solution [UAN]-32% N dribbled and knifed-in) as treatments. Sensor readings were taken from different N response trials …


Effects Of Silicon And Nitrogen Fertilization On Growth, Yield, And Leaf Rust Disease Development In Wheat, Maryamossadat Shahrtash Jan 2017

Effects Of Silicon And Nitrogen Fertilization On Growth, Yield, And Leaf Rust Disease Development In Wheat, Maryamossadat Shahrtash

LSU Master's Theses

There are so many people who have helped me throughout my graduate studies and for whom I am grateful. I would like to take this opportunity to first and foremost thank God for his always guidance throughout my life and giving me the wisdom and the patience I needed to finish my thesis. I would like to thank Dr. Brenda Tubana for taking me in and providing me with guidance and knowledge. I also would like to thank my committee members, Prof. Brian D. LeBlanc who guided me, encouraged me and provided me with knowledge about sustainable agriculture and Dr. …


Vertebral Pathologies And Implications For Economic Lifestyle Changes In Two Prehistoric Skeletal Populations, Alyxandra Leigh Stanco Jan 2017

Vertebral Pathologies And Implications For Economic Lifestyle Changes In Two Prehistoric Skeletal Populations, Alyxandra Leigh Stanco

LSU Master's Theses

Little research considers the vertebral column in relation to inter-populational variation and changes in economic lifestyle. Numerous studies have been conducted regarding the influence of activity-related stress on post-cranial elements such as the knees, hips and shoulders, but few studies have considered the vertebral column. This study examined the vertebral columns of two prehistoric skeletal populations. The Indian Knoll site, home to a population of early hunter-gatherers, is located in Ohio County, Kentucky along the Green River. Indian Knoll was first excavated in 1915 by C.B. Moore. The Moundville site, a chiefdom of early agriculturalists, is located in the Black …


Pesticide Concentrations In Water From A Southern Louisiana Marsh Influenced By The Mississippi River, Kara Leigh Callicott Jan 2017

Pesticide Concentrations In Water From A Southern Louisiana Marsh Influenced By The Mississippi River, Kara Leigh Callicott

LSU Master's Theses

The pesticides atrazine, chlorothalonil, and fipronil are common surface water contaminants due to their high rates of application and their chemical properties. This study investigates the introduction of contaminants into coastal wetlands via the Bayou Lamoque Mississippi River control structure in Plaquemines Parish, Louisiana. A protocol for environmental sampling using Continuous Low-level Aquatic Monitoring (C.L.A.M.) C-18 disks is described, along with effective solid phase extraction (SPE) and gas chromatography mass spectrometry (GC/MS) methodology for the determination of atrazine, chlorothalonil, and fipronil in surface water. Average concentrations of atrazine and chlorothalonil inside the Bayou Lamoque freshwater diversion structure for the months …


Optimization Of The Extraction Of Procyanidin B-2 Rich Extract From Unfermented Cocoa Using Response Surface Methodology And Interaction Of Procyanidin B-2 Rich Cocoa Extract With Collagenase And Elastase As Biomarkers Of Skin Aging, Marco Eduardo Toc Sagra Jan 2017

Optimization Of The Extraction Of Procyanidin B-2 Rich Extract From Unfermented Cocoa Using Response Surface Methodology And Interaction Of Procyanidin B-2 Rich Cocoa Extract With Collagenase And Elastase As Biomarkers Of Skin Aging, Marco Eduardo Toc Sagra

LSU Master's Theses

Skin ageing is a natural process accelerated by environmental exposure that generate reactive oxygen species and activates enzymes that degrade the integrity of the dermis. Cocoa powder (Theobroma cacao) is a good source of polyphenols, particularly procyanidins and flavan-3-ols, with potential enzyme inhibitory activities. In this study we determined whether cocoa extraction standardized to its procyanidin B-2 content has a potential application as anti-ageing bioactive compound. Oil-bath-assisted extraction (OBAE) and microwave-assisted extraction (MAE) were optimized for procyanidin B-2 rich extract using response surface methodology and water as solvent. Methanol (70% in water) extraction was the control to which other extraction …


Baby's Day Out, Andrea Nicole Berg Jan 2017

Baby's Day Out, Andrea Nicole Berg

LSU Master's Theses

Baby's Day Out explores the world through a phenomenological newness that is expressed within abstract figurative painting. Fact and fiction blend in this fantastical array of emotions and real-world referents. I relied on quick mark-making, intuition, and gestural brushwork to explore representations of psychic and emotional states. The results are reminiscent of dreams, poems, secret whispers, unconscious fantasies, and delusions. The viewer is left to navigate the aporia of the space, by gingerly extending each limb forward and backward, to wander from piece to piece. Meaning is relative as the content of each painting is dependent on the interpretive lens …


Sociodemographic, Health, Health-Related, Health Risk, Psychosocial, And Treatment-Related Characteristics Associated With Retention Among Community Mental Health Clients In An Integrated Health Program, Katherine Anne Thomas Jan 2017

Sociodemographic, Health, Health-Related, Health Risk, Psychosocial, And Treatment-Related Characteristics Associated With Retention Among Community Mental Health Clients In An Integrated Health Program, Katherine Anne Thomas

LSU Master's Theses

Individuals with serious mental illness (SMI) have higher rates cardiometabolic conditions than the general population, which put them at increased risk for early mortality. Treatment retention is especially important as it may prevent worsening of mental and physical health symptoms and lower such risks. Models of integrated primary and behavioral health care (PBHC) are promising for treating co-morbid mental and physical health conditions common to individuals with SMI. Previous research identified that individuals with SMI drop out of care at higher rates than other individuals with mental illness. Past studies on treatment retention with this population have been qualitative and …


Play With Power: A City Park Along The Trinity River, Xiwei Shen Jan 2017

Play With Power: A City Park Along The Trinity River, Xiwei Shen

Honors Capstones

No abstract provided.


Weight Management Delivered Through An App, May Help Resolve Body Image Dissatisfaction In Women Enrolled In Wic, Alexis Ariel O’Connell Dec 2016

Weight Management Delivered Through An App, May Help Resolve Body Image Dissatisfaction In Women Enrolled In Wic, Alexis Ariel O’Connell

Honors Capstones

No abstract provided.


Evolutionary Innovation And Diversification Of Carotenoid-Based Pigmentation In Finches, Russell A. Ligon, Richard K. Simpson, Nicholas A. Mason, Geoffrey E. Hill, Kevin J. Mcgraw Dec 2016

Evolutionary Innovation And Diversification Of Carotenoid-Based Pigmentation In Finches, Russell A. Ligon, Richard K. Simpson, Nicholas A. Mason, Geoffrey E. Hill, Kevin J. Mcgraw

Faculty Publications

© 2016 The Author(s). Evolution © 2016 The Society for the Study of Evolution. The ornaments used by animals to mediate social interactions are diverse, and by reconstructing their evolutionary pathways we can gain new insights into the mechanisms underlying ornamental innovation and variability. Here, we examine variation in plumage carotenoids among the true finches (Aves: Fringillidae) using biochemical and comparative phylogenetic analyses to reconstruct the evolutionary history of carotenoid states and evaluate competing models of carotenoid evolution. Our comparative analyses reveal that the most likely ancestor of finches used dietary carotenoids as yellow plumage colorants, and that the ability …


Obese Mice Fed A Diet Supplemented With Enzyme-Treated Wheat Bran Display Marked Shifts In The Liver Metabolome Concurrent With Altered Gut Bacteria, Dorothy A. Kieffer, Brian D. Piccolo, Maria L. Marco, Eun Bae Kim, Michael L. Goodson, Michael J. Keenan, Tamara N. Dunn, Knud Erik Bach Knudsen, Sean H. Adams, Roy J. Martin Dec 2016

Obese Mice Fed A Diet Supplemented With Enzyme-Treated Wheat Bran Display Marked Shifts In The Liver Metabolome Concurrent With Altered Gut Bacteria, Dorothy A. Kieffer, Brian D. Piccolo, Maria L. Marco, Eun Bae Kim, Michael L. Goodson, Michael J. Keenan, Tamara N. Dunn, Knud Erik Bach Knudsen, Sean H. Adams, Roy J. Martin

Faculty Publications

Background: Enzyme-treated wheat bran (ETWB) contains a fermentable dietary fiber previously shown to decrease liver triglycerides (TGs) and modify the gut microbiome in mice. It is not clear which mechanisms explain how ETWB feeding affects hepatic metabolism, but factors (i.e., xenometabolites) associated with specific microbes may be involved. Objective: The objective of this study was to characterize ETWB-driven shifts in the cecal microbiome and to identify correlates between microbial changes and diet-related differences in liver metabolism in diet-induced obese mice that typically display steatosis. Methods: Five-week-old male C57BL/6J mice fed a 45%-lard-based fat diet supplemented with ETWB (20% wt:wt) or …


Mice Fed A High-Fat Diet Supplemented With Resistant Starch Display Marked Shifts In The Liver Metabolome Concurrent With Altered Gut Bacteria, Dorothy A. Kieffer, Brian D. Piccolo, Maria L. Marco, Eun Bae Kim, Michael L. Goodson, Michael J. Keenan, Tamara N. Dunn, Knud Erik Bach Knudsen, Roy J. Martin, Sean H. Adams Dec 2016

Mice Fed A High-Fat Diet Supplemented With Resistant Starch Display Marked Shifts In The Liver Metabolome Concurrent With Altered Gut Bacteria, Dorothy A. Kieffer, Brian D. Piccolo, Maria L. Marco, Eun Bae Kim, Michael L. Goodson, Michael J. Keenan, Tamara N. Dunn, Knud Erik Bach Knudsen, Roy J. Martin, Sean H. Adams

Faculty Publications

Background: High-amylose-maize resistant starch type 2 (HAMRS2) is a fermentable dietary fiber known to alter the gut milieu, including the gut microbiota, which may explain the reported effects of resistant starch to ameliorate obesityassociated metabolic dysfunction. Objective: Our working hypothesis was that HAMRS2-induced microbiome changes alter gut-derived signals (i.e., xenometabolites) reaching the liver via the portal circulation, in turn altering liver metabolism by regulating gene expression and other pathways. Methods: We used a multi-omics systems biology approach to characterize HAMRS2-driven shifts to the cecal microbiome, liver metabolome, and transcriptome, identifying correlates between microbial changes and liver metabolites under obesogenic conditions …


Modern Vet Management Business Plan, Alaina Stanton Dec 2016

Modern Vet Management Business Plan, Alaina Stanton

Honors Capstones

No abstract provided.


Pancreatic Β-Cell Production Of Cxcr3 Ligands Precedes Diabetes Onset, Susan J. Burke, Michael D. Karlstad, Adrianna E. Eder, Kellie M. Regal, Danhong Lu, David H. Burk, J. Jason Collier Nov 2016

Pancreatic Β-Cell Production Of Cxcr3 Ligands Precedes Diabetes Onset, Susan J. Burke, Michael D. Karlstad, Adrianna E. Eder, Kellie M. Regal, Danhong Lu, David H. Burk, J. Jason Collier

Faculty Publications

© 2016 International Union of Biochemistry and Molecular Biology Type 1 diabetes mellitus (T1DM) results from immune cell-mediated reductions in function and mass of the insulin-producing β-cells within the pancreatic islets. While the initial trigger(s) that initiates the autoimmune process is unknown, there is a leukocytic infiltration that precedes islet β-cell death and dysfunction. Herein, we demonstrate that genes encoding the chemokines CXCL9, 10, and 11 are primary response genes in pancreatic β-cells and are also elevated as part of the inflammatory response in mouse, rat, and human islets. We further established that STAT1 participates in the transcriptional control of …


Research Needs To Improve Hypertension Treatment And Control In African Americans, Paul K. Whelton, Paula T. Einhorn, Paul Muntner, Lawrence J. Appel, William C. Cushman, Ana V.Diez Roux, Keith C. Ferdinand, Mahboob Rahman, Herman A. Taylor, Jamy Ard, Donna K. Arnett, Barry L. Carter, Barry R. Davis, Barry I. Freedman, Lisa A. Cooper, Richard Cooper, Patrice Desvigne-Nickens, Nara Gavini, Alan S. Go, David J. Hyman, Paul L. Kimmel, Karen L. Margolis, Edgar R. Miller, Katherine T. Mills, George A. Mensah, Ann M. Navar, Gbenga Ogedegbe, Michael K. Rakotz, George Thomas, Jonathan N. Tobin, Jackson T. Wright, Sung Sug Sarah Yoon, Jeffrey A. Cutler Nov 2016

Research Needs To Improve Hypertension Treatment And Control In African Americans, Paul K. Whelton, Paula T. Einhorn, Paul Muntner, Lawrence J. Appel, William C. Cushman, Ana V.Diez Roux, Keith C. Ferdinand, Mahboob Rahman, Herman A. Taylor, Jamy Ard, Donna K. Arnett, Barry L. Carter, Barry R. Davis, Barry I. Freedman, Lisa A. Cooper, Richard Cooper, Patrice Desvigne-Nickens, Nara Gavini, Alan S. Go, David J. Hyman, Paul L. Kimmel, Karen L. Margolis, Edgar R. Miller, Katherine T. Mills, George A. Mensah, Ann M. Navar, Gbenga Ogedegbe, Michael K. Rakotz, George Thomas, Jonathan N. Tobin, Jackson T. Wright, Sung Sug Sarah Yoon, Jeffrey A. Cutler

Faculty Publications

No abstract provided.