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Comparison Of In-Office Psychiatric Encounters With Out-Of-Office Psychiatric Encounters Regarding Efficacy, Presenteeism, And Self-Perceived Stigma Among Adult Recipients Of Psychiatric Treatment For Depression In Louisiana, Lawrence Sullivan Salone Oct 2020

Comparison Of In-Office Psychiatric Encounters With Out-Of-Office Psychiatric Encounters Regarding Efficacy, Presenteeism, And Self-Perceived Stigma Among Adult Recipients Of Psychiatric Treatment For Depression In Louisiana, Lawrence Sullivan Salone

LSU Doctoral Dissertations

The primary purpose of this study was to conduct a clinical trial to compare the provision of psychiatric evaluation and medication interventions in a virtual out of office format (VOO) with the provision of psychiatric evaluation and medication interventions in a virtual in-office psychiatric encounter (VIO) among adults in Louisiana seeking psychiatric services for the treatment of depression. This study was classified as a pretest-posttest control group non-inferiority double-blind experimental design. Each patient took a self-rated instrument at baseline and at week 8. The study tested the two interventions (VOO and VIO) by way of changes in overall function, changes …


Indeterminate Sample Sequencing In Virtual Reality, Chase Mitchusson Oct 2020

Indeterminate Sample Sequencing In Virtual Reality, Chase Mitchusson

LSU Doctoral Dissertations

The VR Sequencer is a tool for composing and performing music which takes advantage of spatial configuration of 3-D objects to generate looping sequences. This project combines dice-rolling with omnidirectional playheads and variable terrain to make a sequencer with indeterminate features in Virtual Reality (VR). A comparison of mapping systems for music games and digital instruments demonstrates a middle ground for interactive music making which the VR Sequencer applies. An inspection of current VR works exhibits a disconnect be- tween VR gamers and experimental musicians. In an attempt to give the gaming community access to experimental music making, the VR …


From Regulation Of Secondary Metabolites To Increased Virulence Under Sublethal Dosage Of Antibiotics: An Unprecedented Role Of Global Regulator, Mftr, In Burkholderia Thailandensis, Sudarshan Singh Thapa Oct 2020

From Regulation Of Secondary Metabolites To Increased Virulence Under Sublethal Dosage Of Antibiotics: An Unprecedented Role Of Global Regulator, Mftr, In Burkholderia Thailandensis, Sudarshan Singh Thapa

LSU Doctoral Dissertations

The rise of multi-drug resistant bacteria combined with a decreasing pool of effective antibiotics has placed an increasing need for the development of novel antibiotics. Bacterial natural products or secondary metabolites have been the greatest source for development of novel antibiotics. The genus Burkholderia has recently emerged as a source of promising compounds with antibacterial, antifungal, and anti-cancer activities. Bacterial secondary metabolites provide added advantage to bacteria under stressful environments such as during host infection, evading predators or nutrient deficient conditions. However, genes involved in synthesis of these novel compounds remain silent under normal laboratory growth, creating a hurdle in …


Relational Turbulence And Perceptions Of Social Network Support For Parents Of Children With Autism Spectrum Disorder, Kellie St Cyr Brisini, Denise Haunani Solomon Oct 2020

Relational Turbulence And Perceptions Of Social Network Support For Parents Of Children With Autism Spectrum Disorder, Kellie St Cyr Brisini, Denise Haunani Solomon

Faculty Publications

A wealth of research indicates that social support positively influences parental and family well-being in families of children with disabilities; however, not all supportive efforts are positively received. This study employs the framework of relational turbulence theory to examine evaluations of social support from social network members among parents of children with Autism Spectrum Disorder (ASD). In a cross-sectional survey, ninety-four parents of children with ASD (47 heterosexual couples) reported a social network member to whom they disclose issues regarding their marriage and evaluated that network member’s support for their marriage and their parenting. Results of actor-only interdependence modeling demonstrated …


Distribution Of Aromatase In The Brain Of The African Cichlid Fish Astatotilapia Burtoni: Aromatase Expression, But Not Estrogen Receptors, Varies With Female Reproductive-State, Karen P. Maruska, Julie M. Butler, Chase Anselmo, Ganga Tandukar Oct 2020

Distribution Of Aromatase In The Brain Of The African Cichlid Fish Astatotilapia Burtoni: Aromatase Expression, But Not Estrogen Receptors, Varies With Female Reproductive-State, Karen P. Maruska, Julie M. Butler, Chase Anselmo, Ganga Tandukar

Faculty Publications

© 2020 Wiley Periodicals, Inc. Estrogen synthesis and signaling in the brains of vertebrates has pleotropic effects ranging from neurogenesis to modulation of behaviors. The majority of studies on brain-derived estrogens focus on males, but estrogenic signaling in females likely plays important roles in regulation of reproductive cycling and social behaviors. We used females of the mouth brooding African cichlid fish, Astatotilapia burtoni, to test for reproductive state-dependent changes in estrogenic signaling capacity within microdissected brain nuclei that are important for social behaviors. Expression levels of the rate-limiting enzyme aromatase, but not estrogen receptors, measured by qPCR changes across the …


Neural Activation Patterns Associated With Maternal Mouthbrooding And Energetic State In An African Cichlid Fish, Karen P. Maruska, Julie M. Butler, Karen E. Field, Christopher Forester, Ashley Augustus Oct 2020

Neural Activation Patterns Associated With Maternal Mouthbrooding And Energetic State In An African Cichlid Fish, Karen P. Maruska, Julie M. Butler, Karen E. Field, Christopher Forester, Ashley Augustus

Faculty Publications

© 2020 IBRO Parental care is widespread in the animal kingdom, but for many species, provisioning energetic resources must be balanced with trade-offs between self-promoting and offspring-promoting behaviors. However, little is known about the neural mechanisms underlying these motivational decisions. Mouthbrooding is an extreme form of parental care most common in fishes that provides an ideal opportunity to examine which brain regions are involved in parenting and energetics. The African cichlid fish Astatotilapia burtoni is a maternal mouthbrooder in which females hold developing young inside their mouths for 2 weeks. This brood care makes feeding impossible, so females undergo obligatory …


Electronic Self‐Reporting: Angler Attitudes And Behaviors In The Recreational Red Snapper Fishery, Stephen R. Midway, Jason Adriance, Patrick Banks, Sepp Haukebo, Rex Caffey Oct 2020

Electronic Self‐Reporting: Angler Attitudes And Behaviors In The Recreational Red Snapper Fishery, Stephen R. Midway, Jason Adriance, Patrick Banks, Sepp Haukebo, Rex Caffey

Faculty Publications

No abstract provided.


Expression, Purification, And Glycosylation Of Epidermal Growth Factor-Like Repeat 27 From Mouse Notch1, Justin A. Grennell, Kendra D. Jenkins, Huimin Zhong, Amid Paudyal, Kelvin B. Luther, Robert S. Haltiwanger, Megan A. Macnaughtan Oct 2020

Expression, Purification, And Glycosylation Of Epidermal Growth Factor-Like Repeat 27 From Mouse Notch1, Justin A. Grennell, Kendra D. Jenkins, Huimin Zhong, Amid Paudyal, Kelvin B. Luther, Robert S. Haltiwanger, Megan A. Macnaughtan

Faculty Publications

© 2020 Elsevier Inc. Notch receptors have large extracellular domains containing up to 36 tandem epidermal growth factor-like (EGF) repeats, which facilitate cell signaling by binding ligands on neighboring cells. Notch receptors play major roles in a variety of developmental processes by controlling cell fate decisions. Each EGF repeat consists of about 40 amino acids with 3 conserved disulfide bonds. Many of the EGF repeats are modified by O-linked fucose glycans, and more than half have calcium-binding sites, but the sequences of the EGF repeats vary giving distinct roles to each repeat. EGF repeat 27 (EGF27) from mouse NOTCH1 is …


Louisiana Agriculture Fall, 2020 Oct 2020

Louisiana Agriculture Fall, 2020

Louisiana Agriculture

No abstract provided.


Lsu Research Fall 2020, Louisiana State University And Agricultural And Mechanical College Oct 2020

Lsu Research Fall 2020, Louisiana State University And Agricultural And Mechanical College

Research Magazine

LSU Research is published annually by the Office of Research & Economic Development, Louisiana State University.


Fall 2020 Catalog, Lsu Press Oct 2020

Fall 2020 Catalog, Lsu Press

LSU Press Seasonal Catalogs

No abstract provided.


Montana Native Entomopathogenic Nematode Species Against Limonius Californicus (Coleoptera: Elateridae), Ramandeep Kaur Sandhi, David Shapiro-Ilan, Gadi V.P. Reddy Oct 2020

Montana Native Entomopathogenic Nematode Species Against Limonius Californicus (Coleoptera: Elateridae), Ramandeep Kaur Sandhi, David Shapiro-Ilan, Gadi V.P. Reddy

Faculty Publications

Wireworms are destructive soil inhabiting polyphagous pests in the Pacific Northwest and Intermountain region of the United States. Continuously increasing wireworm populations and damage in small grain crops such as spring wheat in Northern Great Plains has become a challenge for growers. Due to unavailability of effective control measures, alternative methods, including biological control agents such as entomopathogenic nematodes (EPNs) are needed. Native/indigenous EPN species are expected to have better potential than exotic species to control the local insect pests. Two Montana native EPN species (Steinernema feltiae and Heterorhabditis bacteriophora) were tested against, Limonius californicus (Coleoptera: Elateridae) in laboratory and …


Third-Variable Effect Analysis With Multilevel Additive Models, Qingzhao Yu, Bin Li Oct 2020

Third-Variable Effect Analysis With Multilevel Additive Models, Qingzhao Yu, Bin Li

Faculty Publications

Third-variable effect refers to the effect transmitted by third-variables that intervene in the relationship between an exposure and a response variable. Third-variable effect analysis has been broadly studied in many fields. However, it remains a challenge for researchers to differentiate indirect effect of individual factor from multiple third-variables, especially when the involving variables are of hierarchical structure. Yu et al. (2014) defined third-variable effects that were consistent for all different types of response (categorical or continuous), exposure, or third-variables. With these definitions, multiple third-variables can be considered simultaneously, and the indirect effects carried by individual third-variables can be separated from …


F20rs 3rd Legislative Week Minutes, Senate Secretary Oct 2020

F20rs 3rd Legislative Week Minutes, Senate Secretary

Student Senate Meeting Minutes

No abstract provided.


Psychological Mechanisms Associated With Food Security Status And Bmi In Adults: A Mixed Methods Study, Candice A. Myers, Robbie A. Beyl, Corby K. Martin, Stephanie T. Broyles, Peter T. Katzmarzyk Oct 2020

Psychological Mechanisms Associated With Food Security Status And Bmi In Adults: A Mixed Methods Study, Candice A. Myers, Robbie A. Beyl, Corby K. Martin, Stephanie T. Broyles, Peter T. Katzmarzyk

Clinical Research Faculty Publications

Objective: This study examined psychological constructs (delay discounting, grit, future time perspective and subjective social status) in relation to food security status and body weight.Design: A simultaneous triangulation mixed methods design was used to collect quantitative and qualitative data. Quantitative data were collected in fifty-six adults. Independent variables included food security status (food secure or food insecure) and BMI category (normal weight or overweight/obese). Participants, matched on race (African American and White), were categorised into four food security status by BMI category groups. Psychological constructs were measured via validated questionnaires. Qualitative data were collected in a subsample of twelve participants …


Exploring New And Modified Rejection-Type Thresholds Using Cricket Snack Crackers, Ryan Ardoin, Ross Romero, Brian Marx, Witoon Prinyawiwatkul Oct 2020

Exploring New And Modified Rejection-Type Thresholds Using Cricket Snack Crackers, Ryan Ardoin, Ross Romero, Brian Marx, Witoon Prinyawiwatkul

Faculty Publications

Recently, sensory threshold concepts have been expanded to include affective perceptions of foods and beverages, especially measures of product rejection; however, each threshold interpretation depends largely on the methodology employed. By substituting cricket powder for whole-wheat flour in snack crackers (0%, 5%, 10%, 15%, and 20%), we proposed modifications to two existing threshold methodologies: a modified consumer rejection threshold (M-CRT) using a 2-alternative choice (2-AC) preference test with “no preference” option; and a modified hedonic rejection threshold (M-HRT) based on less-than-neutral hedonic scores according to a one-sample t-test. We also proposed two new concepts: a rejection tolerance threshold (RTT) and …


Intervention To Improve Preschool Children’S Fundamental Motor Skills: Protocol For A Parent-Focused, Mobile App–Based Comparative Effectiveness Trial, E. Kipling Webster, Chelsea L. Kracht, Robert L. Newton, Robbie A. Beyl, Amanda E. Staiano Oct 2020

Intervention To Improve Preschool Children’S Fundamental Motor Skills: Protocol For A Parent-Focused, Mobile App–Based Comparative Effectiveness Trial, E. Kipling Webster, Chelsea L. Kracht, Robert L. Newton, Robbie A. Beyl, Amanda E. Staiano

Population and Public Health Science Faculty Publications

Background: Preschool age is an important time to master fundamental motor skills (FMS) through structured physical activity, yet many young children lag behind in motor skill development. Objective: The Promoting Lifelong Activity in Youth (PLAY) study is a pilot comparative effectiveness trial to test the acceptability, feasibility, and preliminary effectiveness of a mobile app delivered to parents to promote FMS development in their preschool children (aged 3-5 years). Methods: We conducted a 2-arm, parallel-design, randomized comparative effectiveness trial in 72 parent-child dyads from the southeastern United States. Experts in motor development and developmental psychology developed an app designed to deliver …


Detection And Estimation Of Inundation And Associated Risks Using Traffic And Monitoring Cameras And Image Processing Under Extreme Flooding Conditions, Suyun Ham Ph.D, Seongjin Noh Ph.D, Dong-Jun Seo Ph.D, Yin Chao Yu, Sangoo Kang Oct 2020

Detection And Estimation Of Inundation And Associated Risks Using Traffic And Monitoring Cameras And Image Processing Under Extreme Flooding Conditions, Suyun Ham Ph.D, Seongjin Noh Ph.D, Dong-Jun Seo Ph.D, Yin Chao Yu, Sangoo Kang

Publications

The main objective of this project is to develop an inundation detection and evaluation framework using images from traffic monitoring cameras and reliable flood monitoring under extreme precipitation conditions. This study presents a comparative assessment of image enhancement and segmentation techniques to automatically identify the flash flooding from the low-resolution images taken by traffic-monitoring cameras. Due to inaccurate equipment in severe weather conditions (e.g., raindrops or light refraction on camera lenses), low-resolution images are subject to noises that degrade the quality of information. De-noising procedures are carried out for the enhancement of images by removing different types of noises. After …


Development And Initial Validation Of The Adult Coping Inventory, Kristen Hollas Sep 2020

Development And Initial Validation Of The Adult Coping Inventory, Kristen Hollas

LSU Master's Theses

There are few psychometrically sound measures for assessing coping in adults. For example, a widely used measure of coping, the COPE, has highly unstable sub-scale analyses (Lyne & Roger, 2000). The scarcity of instruments developed using evidence based “best practice” is concerning as coping skills are linked to a variety of positive and negative outcomes. For example, positive coping skills have been linked to better health outcomes among various populations (Garnefski & Kraaij, 2006; Littleton, Horsley, John & Nelson, 2007). This study aimed to address the lack of psychometrically sound measures of coping for an adult population. The current study …


Baton Rouge Collective Healing Initiative: Final Report, Jada Thomas-Smith, Judith F. Rhodes, Kristie Perry Sep 2020

Baton Rouge Collective Healing Initiative: Final Report, Jada Thomas-Smith, Judith F. Rhodes, Kristie Perry

Reports

In response to recent and historic traumatic events that caused distrust and strained relationships between law enforcement and their communities, the U. S. Department of Justice, Office of Victims of Crime (OVC), selected five demonstration sites to invest in restorative and healing activities to repair community-police relationships.

The International Association of Chiefs of Police (IACP) worked closely with the sites over the three-year grant period to improve relations through evidence-based interventions, technical assistance, and peer learning. The program, Law Enforcement and the Communities They Serve: Supporting Collective Healing in the Wake of Harm began in the selected cities, which included …


Low Aflatoxin Levels In Aspergillus Flavus-Resistant Maize Are Correlated With Increased Corn Earworm Damage And Enhanced Seed Fumonisin, Subbaiah Chalivendra, Fangneng Huang, Mark Busman, W. Paul Williams, Jong Hyun Ham Sep 2020

Low Aflatoxin Levels In Aspergillus Flavus-Resistant Maize Are Correlated With Increased Corn Earworm Damage And Enhanced Seed Fumonisin, Subbaiah Chalivendra, Fangneng Huang, Mark Busman, W. Paul Williams, Jong Hyun Ham

Faculty Publications

Preharvest mycotoxin contamination of field-grown crops is influenced not only by the host genotype, but also by inoculum load, insect pressure and their confounding interactions with seasonal weather. In two different field trials, we observed a preference in the natural infestation of corn earworm (CEW; Helicoverpa zea Boddie) to specific maize (Zea mays L.) genotypes and investigated this observation. The field trials involved four maize lines with contrasting levels of resistance to Aspergillus flavus. The resistant lines had 7 to 14-fold greater infested ears than the susceptible lines. Seed aflatoxin B1 (AF) levels, in mock- and A. flavus-inoculated ears were …


Demographic, Jurisdictional, And Spatial Effects On Social Distancing In The United States During The Covid-19 Pandemic, Rajesh P. Narayanan, James Nordlund, R. Kelley Pace, Dimuthu Ratnadiwakara Sep 2020

Demographic, Jurisdictional, And Spatial Effects On Social Distancing In The United States During The Covid-19 Pandemic, Rajesh P. Narayanan, James Nordlund, R. Kelley Pace, Dimuthu Ratnadiwakara

Faculty Publications

Social distancing, a non-pharmaceutical tactic aimed at reducing the spread of COVID-19, can arise because individuals voluntarily distance from others to avoid contracting the disease. Alternatively, it can arise because of jurisdictional restrictions imposed by local authorities. We run reduced form models of social distancing as a function of county-level exogenous demographic variables and jurisdictional fixed effects for 49 states to assess the relative contributions of demographic and jurisdictional effects in explaining social distancing behavior. To allow for possible spatial aspects of a contagious disease, we also model the spillovers associated with demographic variables in surrounding counties as well as …


Weather Derivatives And The Market Price Of Risk, Julius Esunge, James J. Njong Sep 2020

Weather Derivatives And The Market Price Of Risk, Julius Esunge, James J. Njong

Journal of Stochastic Analysis

No abstract provided.


Effect Of Oxidation Level On The Interfacial Water At The Graphene Oxide-Water Interface: From Spectroscopic Signatures To Hydrogen-Bonding Environment, Rolf David, Aashish Tuladhar, Le Zhang, Christopher Arges, Revati Kumar Sep 2020

Effect Of Oxidation Level On The Interfacial Water At The Graphene Oxide-Water Interface: From Spectroscopic Signatures To Hydrogen-Bonding Environment, Rolf David, Aashish Tuladhar, Le Zhang, Christopher Arges, Revati Kumar

Faculty Publications

Copyright © 2020 American Chemical Society. The interfacial region of the graphene oxide (GO)-water system is nonhomogenous due to the presence of two distinct domains: an oxygen-rich surface and a graphene-like region. The experimental vibrational sum-frequency generation (vSFG) spectra are distinctly different for the fully oxidized GO-water interface as compared to the reduced GO-water case. Computational investigations using ab initio molecular dynamics were performed to determine the molecular origins of the different spectroscopic features. The simulations were first validated by comparing the simulated vSFG spectra to those from the experiment, and the contributions to the spectra from different hydrogen bonding …


Effect Of Oxidation Level On The Interfacial Water At The Graphene Oxide-Water Interface: From Spectroscopic Signatures To Hydrogen-Bonding Environment, Rolf David, Aashish Tuladhar, Le Zhang, Christopher Arges, Revati Kumar Sep 2020

Effect Of Oxidation Level On The Interfacial Water At The Graphene Oxide-Water Interface: From Spectroscopic Signatures To Hydrogen-Bonding Environment, Rolf David, Aashish Tuladhar, Le Zhang, Christopher Arges, Revati Kumar

Faculty Publications

The interfacial region of the graphene oxide (GO)-water system is nonhomogenous due to the presence of two distinct domains: an oxygen-rich surface and a graphene-like region. The experimental vibrational sum-frequency generation (vSFG) spectra are distinctly different for the fully oxidized GO-water interface as compared to the reduced GO-water case. Computational investigations using ab initio molecular dynamics were performed to determine the molecular origins of the different spectroscopic features. The simulations were first validated by comparing the simulated vSFG spectra to those from the experiment, and the contributions to the spectra from different hydrogen bonding environments and interfacial water orientations were …


A 5200-Year Paleoecological And Geochemical Record Of Coastal Environmental Changes And Shoreline Fluctuations In Southwestern Louisiana: Implications For Coastal Sustainability, Qiang Yao, Kam Biu Liu, Alejandro Antonio Aragón-Moreno, Erika Rodrigues, Y. Jun Xu, Nina S. Lam Sep 2020

A 5200-Year Paleoecological And Geochemical Record Of Coastal Environmental Changes And Shoreline Fluctuations In Southwestern Louisiana: Implications For Coastal Sustainability, Qiang Yao, Kam Biu Liu, Alejandro Antonio Aragón-Moreno, Erika Rodrigues, Y. Jun Xu, Nina S. Lam

Faculty Publications

This study presents a 5200-year history of coastal environmental changes and shoreline fluctuations based on a multi-proxy sedimentary record developed from the eastern end of Louisiana's Chenier Plain. Palynological, loss-on ignition, grain-size, and X-ray fluorescence data for a 525 cm sedimentary core indicate five stages of ecosystem development in the Rockefeller Wildlife Refuge since the mid-Holocene. Between 5190 and 4240 cal yr BP, the relative sea-level was much lower than the present level, and our study area was occupied by a baldcypress swamp. When the Sale-Cypremont subdelta complex formed at a western position approximately 4600 years ago, our study area …


Security Analysis Of The Anonabox Pro, Devi Sowjanya Vempati Sep 2020

Security Analysis Of The Anonabox Pro, Devi Sowjanya Vempati

LSU Master's Theses

The security posture of critical network appliances, such as routers, switches, and firewalls, is crucial as these devices provide the first line of defense against malicious actors. As there is typically no endpoint security software, such as anti-virus available for these devices, it is crucial that vendors release timely updates for vulnerabilities and that customers apply them quickly. The research effort documented in this thesis describes a developed methodology for triaging known vulnerabilities in network devices, assessing the security posture of device vendors, and locating likely weak points in released firmware images. To highlight this methodology, the Anonabox security appliance …


Natural Environment And Childhood Obesity: A Systematic Review, Robert Rohli Sep 2020

Natural Environment And Childhood Obesity: A Systematic Review, Robert Rohli

Faculty Publications

No abstract provided.


Mechanisms Of Artemisia Scoparia’S Anti-Inflammatory Activity In Cultured Adipocytes, Macrophages, And Pancreatic Β-Cells, Anik Boudreau, Susan J. Burke, J. Jason Collier, Allison J. Richard, David M. Ribnicky, Jacqueline M. Stephens Sep 2020

Mechanisms Of Artemisia Scoparia’S Anti-Inflammatory Activity In Cultured Adipocytes, Macrophages, And Pancreatic Β-Cells, Anik Boudreau, Susan J. Burke, J. Jason Collier, Allison J. Richard, David M. Ribnicky, Jacqueline M. Stephens

Faculty Publications

© 2020 The Obesity Society Objective: An ethanolic extract of Artemisia scoparia (SCO) improves adipose tissue function and reduces negative metabolic consequences of high-fat feeding. A. scoparia has a long history of medicinal use across Asia and has anti-inflammatory effects in various cell types and disease models. The objective of the current study was to investigate SCO’s effects on inflammation in cells relevant to metabolic health. Methods: Inflammatory responses were assayed in cultured adipocytes, macrophages, and insulinoma cells by quantitative polymerase chain reaction, immunoblotting, and NF-κB reporter assays. Results: In tumor necrosis factor α–treated adipocytes, SCO mitigated ERK and NF-κB …


The Cdk Inhibitor Siamese Targets Both Cdka;1 And Cdkb1 Complexes To Establish Endoreplication In Trichomes1[Open], Kai Wang, Ruth W. Ndathe, Narender Kumar, Elizabeth A. Zeringue, Naohiro Kato, John C. Larkin Sep 2020

The Cdk Inhibitor Siamese Targets Both Cdka;1 And Cdkb1 Complexes To Establish Endoreplication In Trichomes1[Open], Kai Wang, Ruth W. Ndathe, Narender Kumar, Elizabeth A. Zeringue, Naohiro Kato, John C. Larkin

Faculty Publications

© 2020 American Society of Plant Biologists. All rights reserved. Endoreplication, also known as endoreduplication, is a modified cell cycle in which DNA is replicated without subsequent cell division. Endoreplication plays important roles in both normal plant development and in stress responses. The SIAMESE (SIM) gene of Arabidopsis (Arabidopsis thaliana) encodes a cyclin-dependent kinase (CDK) inhibitor that plays a central role in establishing endoreplication, and is the founding member of the SIAMESE-RELATED (SMR) family of plant-specific CDK inhibitor genes. However, there has been conflicting evidence regarding which specific cyclin/CDK complexes are inhibited by SIM in vivo. In this work, we …