Digital Commons Network^™

Incorporation Of Lignin In Natural And Synthetic Biomaterials To Alter Mechanical And Biochemical Properties For Enhanced Wound Healing, Jorge Alfonso Belgodere

LSU Doctoral Dissertations

It is estimated that chronic, non-healing wounds affect more than 6.5 million Americans annually, with an estimated healthcare cost beyond $14 billion. Here, we attempted to create composites of natural (collagen type I or gelatin-methacrylate) or synthetic (poly(ethylene glycol) polymers incorporating a natural plant component, lignin, to combat the costs and limitations current wound healing methods face. Three-dimensional matrices of collagen type I (Col I) are widely used in tissue engineering applications for its abundance in many tissues, bioactivity with many cell types, and excellent biocompatibility. Inspired by the structural role of lignin in plant tissue, we found that sodium …

College Expectation And Matriculation: High School Students Journey To Postsecondary, Sabrina Juanita Johnson

LSU Doctoral Dissertations

Racial group membership and social-economic status (SES) among academically talented students are recognized as powerful predictors of matriculation and college expectations. Moving or transitioning from high school to college is an essential pathway for success in life. Previous research suggests that college enrollment is correlated to resource opportunities available to students that they can access through their relationship with their parents, peers, school staff, teachers, and others.

These relationships are vital in increasing college matriculation by providing academic assistance, emotional support, psychological encouragement, relevant information, and guidance to students in the complex college application process.

College preparatory or outreach programs …

University Faculty Design-Thinking Personas For Online Course Development: A Q Methodological Study, Jennifer Margaret Morrisette

LSU Doctoral Dissertations

To overcome the inherent complexities of planning and implementing effective online learning experiences at scale, it has been suggested that design-thinking tools and practices can be leveraged by faculty and collaborative support staff (e.g., instructional designers). However, little is known about what design-thinking approaches are perceived by faculty to be important to the online course design process, and what tools and practices might be prioritized or avoided given planning stage and individual context. Understanding these nuances would provide much needed insight to align support directly with faculty needs. This study used Q methodology to explore the subjective viewpoints of 20 …

Evaluation Of Louisiana Farm To School Programming: Harvest Of The Month And Local Food Procurement, Arin M. Shaffer

LSU Master's Theses

Farm to school is a growing movement that is beginning to draw serious interest in different parts of the United States due to its ability to connect communities with their local producers while providing many benefits. Farm to school entails three main components: school gardening, education and curriculum, and local food procurement. The farm to school movement is relatively new to the state of Louisiana and very little research has been conducted to evaluate the impact of the farm to school programs on local food procurement and the effect on school food environments. Case studies of three Louisiana parish school …

The Implications Of The American Symphonic Heritage In Contemporary Orchestral Modeling, Mathew Lee Ward

LSU Doctoral Dissertations

Disparate priorities between composers, performers, audiences, and institutions have created systemic issues in the sustainability and relevance of symphonic music in modern society. The purpose of this study is to explore the history of the symphonic heritage in the United States with the goal of forming solutions to contemporary issues in the sphere of classical symphonic music. With consideration for the breadth of repertoire, the genre of the symphony is the primary focus, with special attention given to under-represented and under-performed composers. The American symphony orchestra, nonexistent during the founding of the country, has become one of the greatest conduits …

Identification Of Novel Host Genes Required For Antiviral Immunity And Viral Genome Replication In C. Elegans, Fei Meng

LSU Doctoral Dissertations

RNA interference (RNAi) is a wide-spread gene silencing mechanism that control diverse biological functions and triggered by small interfering RNAs (siRNAs) processed from the viral genome or its replication intermediates. Mechanistic studies of antiviral RNAi in Caenorhabditis elegans has led to the identification of several critical factors involved in the process. As a result, whether antiviral RNAi requires additional novel genes remains to be an open question.

Viruses are intracellular parasites that rely on host products for reproduction. Disrupting their interaction with host factors can significantly compromise their replication and keep them under control. Thus, identification of host genes …

An Approach To Counting Vehicles From Pre-Recorded Video Using Computer Algorithms, Mishuk Majumder

LSU Master's Theses

One of the fundamental sources of data for traffic analysis is vehicle counts, which can be conducted either by the traditional manual method or by automated means. Different agencies have guidelines for manual counting, but they are typically prepared for particular conditions. In the case of automated counting, different methods have been applied, but You Only Look Once (YOLO), a recently developed object detection model, presents new potential in automated vehicle counting. The first objective of this study was to formulate general guidelines for manual counting based on experience gained in the field. Another goal of this study was to …

Recoding The Archive: Memory And Identity In The Photographic And Filmic Works Of Shirin Neshat, Shoja Azari, And Alia Ali, Olivia K. Johnson

LSU Master's Theses

Shirin Neshat, Shoja Azari, and Alia Ali are artists of Middle Eastern descent living and working in the United States, mainly in photographic and filmic modes. Neshat and Azari were born in Iran and immigrated to the U.S. amid the 1979 Iranian Revolution, which drastically changed the political and cultural landscape of the country. Ali was born in Yemen but her father is specifically South Yemeni and her mother Yugoslavian, two countries that no longer exist. As artists experiencing exile and diaspora, with complicated relationships to their home countries, their identities are muddled by hybridity and the struggle between being …

Adsorption And Reconfiguration Of Amphiphiles At Silica-Water Interfaces: Role Of Electrostatic Interactions, Van Der Waals Forces And Hydrogen Bonds, Yao Wu

LSU Doctoral Dissertations

The ability to explore and predict metastable structures of hybrid self-assemblies is of central importance for the next generation of advanced materials with novel properties. As compared to their thermodynamically stable forms, the kinetically stabilized materials show improved functionality potentially over their stable counterparts. The self-assembly processes usually originate from weak intermolecular interactions, involving a dynamic competition between attractive and repulsive interactions. These weak forces, including van der Waals (vdW), electrostatic interaction and the hydrogen bonding (H-bonding), can be tuned by external stimuli, e.g., confinement, temperature and ionization, and consequently driving hybrid materials into different configurations. It is challenging to …

«Astrología Y Genealogía De Poder En La Vida Es Sueño De Calderón De La Barca Y La Comedia Anónima El Vaticinio Cumplido: La Estrella De Inglaterra.», Carmela V. Mattza

Faculty Publications

¿En qué medida la relación entre astrología y genealogía de autoridad y poder presente en la comedia calderoniana puede servirnos para estudiar otras comedias áureas de temas parecidos? ¿Hasta qué punto la presencia de esos discursos genealógicos puede echar luz sobre el uso de la comedia como propaganda? A manera de respuesta, en la presente comunicación presentada en el congreso de la Asociación Internacional de Siglo de Oro celebrado en Madrid en 2017, me propongo estudiar y comparar la función del eclipse en La vida es sueño, la comedia paradigmática de Calderón, con la que aparece en la comedia …

Regulation Of Mpcs And Kat8 During Adipogenesis And Nutritional Regulation, Jasmine Burrell

LSU Doctoral Dissertations

Obesity is a global epidemic characterized by an expansion of adipose tissue. Adipose tissue, composed of adipocytes and a stromal vascular fraction, is an endocrine organ that regulates whole body homeostasis. Obesity leads to the dysregulation of adipocytes and is often associated with increased susceptibility to metabolic diseases such as Type II diabetes mellitus (T2DM). Understanding the mechanisms by which adipocyte function and development are regulated is crucial. Mitochondrial pyruvate carriers (MPCs) are transmembrane proteins that transport pyruvate from the cytosol into the mitochondrial matrix to generate acetyl CoA. Although MPCs have been studied extensively, their roles in adipocytes are …

Boxwood Dieback: Molecular Detection, In-Vitro Fungicide Efficacy, And Host Susceptibility For Managing A New Emerging Disease Caused By Colletotrichum Theobromicola, Harleen Kaur

LSU Master's Theses

Boxwood (Buxus spp. L) is one of the most common and widely planted perennial ornamentals in both home gardens and commercial landscapes. Grown for its evergreen, dark green foliage, boxwood cultivation dates back to 4000 BC in Egypt. Although considered hardy, boxwood is susceptible to several plant pathogens. Recently reported boxwood dieback, a fungal disease caused by Colletotrichum theobromicola, has been spreading at an alarming rate within the United States. Boxwood dieback consists of symptoms that resemble to those caused by Phytophthora root rot, Volutella blight, and some abiotic disorders and can be easily misdiagnosed in nurseries and …

P-Cresol Biogenesis During Bioremediation Aimed At Stimulating Chlorinated Solvent Dehalogenation, Alexis Gathings

LSU Master's Theses

The broad goal of the research described in this thesis was to better understand the potential for biologically mediated production of p-cresol in groundwater at a Superfund site located in south Louisiana. Previous literature reports that microorganisms known to carry out the transformation from L-tyrosine to p-cresol occur in diverse environments.

In the research described in this thesis, studies were conducted utilizing groundwater from the Superfund site during the course of enhanced in situ bioremediation practices aimed at stimulating reductive dehalogenation of chlorinated solvent contamination. Microbial communities established with groundwater sampled from the Superfund site were observed to …

Civil War Interventions: An Examination Of The Roles Of The Media, Political Executives, And The Domestic Opposition, Jonathan Charles Nickens

LSU Doctoral Dissertations

This dissertation examines how media attention and domestic opposition parties affect third-party intervention in foreign civil wars. Previous research defines some of the ways that political executives in democratic states are constrained in their choice of actions, while also pointing out the influences and limitations of outside actors. This dissertation builds on existing research pertaining to opposition parties and the news media by providing new theories on how these outside actors can push a leader in taking an action he otherwise might not take, such as intervening in a foreign civil war. Using newly collected data, I argue that the …

Salt Dependence Of Thermodynamic Stability Of A Cold-Active Dna Polymerase I Fragment, Xinji Zhu

LSU Doctoral Dissertations

P. ingrahamii is a halo-psychrophilic bacterium isolated from Arctic sea ice. We have cloned and purified the large fragment of the cold-active DNA polymerase I from P. ingrahamii, named Klenpin. The objective of this project is to directly compare the thermodynamic stability of Klenpin, and the salt dependence of that stability, with Klenow and Klentaq; two homologous polymerases from a mesophile (E. coli) and a thermophile (Thermus aquaticus).

We first examined the effects of salts on the thermal stability (Tm) of Klenpin and Klenow across the Hofmeister series. Significantly different trends were observed on …

Chain-Selective Isotopic Labeling Of The Heterodimeric Type Iii Secretion Chaperone, Scc4:Scc1, Reveals The Total Structural Rearrangement Of The Chlamydia Trachomatis Bi-Functional Protein, Scc4, Thilini O. Ukwaththage, Samantha M. Keane, Li Shen, Megan A. Macnaughtan

Faculty Publications

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Scc4 is an unusual bi-functional protein from Chlamydia trachomatis (CT) that functions as a type III secretion system (T3SS) chaperone and an RNA polymerase (RNAP)-binding protein. Both functions require interactions with protein partners during specific stages of the CT developmental cycle. As a T3SS chaperone, Scc4 binds Scc1 during the late stage of development to form a heterodimer complex, which chaperones the essential virulence effector, CopN. During the early-middle stage of development, Scc4 regulates T3SS gene expression by binding the σ66-containing RNAP holoenzyme. In order to study the structure and association …

Psychological, Addictive, And Health Behavior Implications Of The Covid-19 Pandemic, Michael J. Zvolensky, Lorra Garey, Andrew H. Rogers, Norman B. Schmidt, Anka .. Vujanovic, Eric A. Storch, Julia D. Buckner, Daniel J. Paulus, Candice Alfano, Jasper A. J. Smits, Connall O'Cleirigh

Faculty Publications

No abstract provided.

Microbiological, Physicochemical, And Immunological Analysis Of A Commercial Cashew Nut-Based Yogurt, Christopher P. Mattison, Kayanush Aryana, Kristen Clermont, Eric Prestenburg, Steven W. Lloyd, Casey .. Grimm, Richard L. Wasserman

Faculty Publications

Nut-based milks and yogurts are gaining popularity, but may not offer the same benefits as dairy yogurts to consumers. Cashew nuts often cause severe allergic reactions, and cashew nut allergens are stable to several types of processing. To compare its characteristics to dairy yogurt and characterize the effects of fermentation on the Ana o 1-3 cashew nut allergens, a commercial yogurt made from cashew nuts (Cashewgurt) was evaluated for microbiological, physiochemical, and immunological properties. Average counts for lactobacilli and Streptococcus thermophilus were greater than 10 million colony forming units per milliliter, indicating the capacity to provide a health benefit. Cashewgurt …

Speciation-By-Depth On Coral Reefs: Sympatric Divergence With Gene Flow Or Cryptic Transient Isolation?, Carlos Prada, Michael E. Hellberg

Faculty Publications

The distributions of many sister species in the sea overlap geographically but are partitioned along depth gradients. The genetic changes leading to depth segregation may evolve in geographic isolation as a prerequisite to coexistence or may emerge during primary divergence leading to new species. These alternatives can now be distinguished via the power endowed by the thousands of scorable loci provided by second-generation sequence data. Here, we revisit the case of two depth-segregated, genetically isolated ecotypes of the nominal Caribbean candelabrum coral Eunicea flexuosa. Previous analyses based on a handful of markers could not distinguish between models of genetic exchange …

Discrimination Of Wear And Non-Wear In Infants Using Data From Hip- And Ankle-Worn Devices, Samuel R. Lamunion, Scott E. Crouter, Nicholas T. Broskey, Abby D. Altazan, Leanne M. Redman

Clinical Research Faculty Publications

Introduction A key component to analyzing wearable sensor data is identifying periods of non-wear. Traditionally, strings of consecutive zero counts (e.g. >60-minutes) are identified indicating periods of non-movement. The non-movement window length is then evaluated as wear or nonwear. Given that non-movement is not equivalent to non-wear, additional criteria should be evaluated to objectively identify periods of non-wear. Identifying non-wear is especially challenging in infants due to their sporadic movement, sleep frequency, and proportion of caregiver- generated movement. Purpose To use hip- and ankle-worn ActiGraph wGT3X-BT (wGT3X-BT) data to identify non-wear in infants. Methods Fifteen infant participants [mean±SD; age, 8.7±1.7 …

Exploring The Role Of Ccp1 And Ccp2 In The Chlamydomonas Reinhardtii Carbon Dioxide Concentrating Mechanism, Lillian Laplace

Honors Capstones

No abstract provided.

The Warner Theater Business Plan, Nicholas Adams

Honors Capstones

No abstract provided.

Demographic Impacts Of Climate-Induced Migration And Environmental Shocks And Stressors In Cameron Parish, Louisiana, John Green Iii

Honors Capstones

No abstract provided.

A Theory Of Multiformat Communication: Mechanisms, Dynamics, And Strategies, Jordan W. Moffett, Judith Anne Garretson Folse, Robert W. Palmatier

Faculty Publications

Extant communication theories predate the explosion of digital formats and technological advances such as virtual reality, which likely explains their predominant focus on traditional and format-level (e.g., face-to-face, email) rather than digital or characteristic-level (e.g., visual cues, synchronicity) design decisions. Firms thus lack insights into how to create and use emerging digital formats, individually or synergistically. To establish a holistic framework of bilateral multiformat communication for relationship marketing, this article reviews communication theory to establish a foundation for understanding multiformat communication and to identify any gaps (e.g., AI agents, simulated cues). The authors then review bilateral communication research in light …

Potential Link Between Compromised Air Quality And Transmission Of The Novel Corona Virus (Sars-Cov-2) In Affected Areas, M. G. Manoj, M. K. Satheesh Kumar, K. T. Valsaraj, C. Sivan, Soumya K. Vijayan

Faculty Publications

The emergence of a novel human corona virus disease (COVID-19) has been declared as a pandemic by the World Health Organization. One of the mechanisms of airborne transmission of the severe acute respiratory syndrome corona virus (SARS-CoV-2) amid humans is through direct ejection of droplets via sneezing, coughing and vocalizing. Nevertheless, there are ample evidences of the persistence of infectious viruses on inanimate surfaces for several hours to a few days. Through a critical review of the current literature and a preliminary analysis of the link between SARS-CoV-2 transmission and air pollution in the affected regions, we offer a perspective …

Novel Targets In Glucose Homeostasis And Obesity—Lesson From Rare Mutations, Bing Feng, Pingwen Xu, Yanlin He

Division of Basic Science Faculty Publications

Purpose of Review: Obesity and diabetes have already become the second largest risk factor for cardiovascular disease. During the last decade, remarkable advances have been made in understanding the human genome’s contribution to glucose homeostasis disorders and obesity. A few studies on rare mutations of candidate genes provide potential genetic targets for the treatment of diabetes and obesity. In this review, we discussed the detailed findings of these studies and the possible causalities between specific genetic variations and dysfunctions in energy or glucose homeostasis. We are optimistic that novel therapeutic strategies targeting these specific mutants for treating and preventing diabetes …

Indirect, Non-Thermal Atmospheric Plasma Promotes Bacterial Killing In Vitro And Wound Disinfection In Vivo Using Monogenic And Polygenic Models Of Type 2 Diabetes (Without Adverse Metabolic Complications), Chris R. Cooley, John Mark Mclain, Samuel D. Dupuy, Adrianna E. Eder, Molly Wintenberg, Kimberly Kelly-Wintenberg, Alan Wintenberg, J. Jason Collier, Susan J. Burke, Michael D. Karlstad

Division of Basic Science Faculty Publications

ABSTRACTA novel atmospheric plasma device that uses indirect, non-thermal plasma generated from room air is being studied for its effects on wound disinfection in animal wounds of monogenic and polygenic murine models of type 2 diabetes. As a proof-of-concept report, the goal of this study was to demonstrate the efficacy and safety of the indirect non-thermal plasma (INTP) device in disinfecting polycarbonate filters established with Pseudomonas aeruginosa (PAO1) biofilms as well as wound disinfection in diabetic murine wounds. Dorsal excisional wounds in BALB/c, polygenic TALLYHO, and monogenic db/db mice established with PAO1 infection all demonstrated a 3-log colony-forming unit (CFU) …

Deploying A Task-Based Runtime System On Raspberry Pi Clusters, Nikunj Gupta, Steve R. Brandt, Bibek Wagle, Nanmiao Wu, Alireza Kheirkhahan, Patrick Diehl, Felix W. Baumann, Hartmut Kaiser

Faculty Publications

Arm® technology is becoming increasingly important in HPC. Recently, Fugaku, an Arm®-based system, was awarded the number one place in the Top500 list. Raspberry Pis provide an inexpensive platform to become familiar with this architecture. However, Pis can also be useful on their own. Here we describe our efforts to configure and benchmark the use of a Raspberry Pi cluster with the HPX/Phylanx platform (normally intended for use with HPC applications) and document the lessons we learned. First, we highlight the required changes in the configuration of the Pi to gain performance. Second, we explore how limited memory bandwidth limits …

Towards A Scalable And Distributed Infrastructure For Deep Learning Applications, Bita Hasheminezhad, Shahrzad Shirzad, Nanmiao Wu, Patrick Diehl, Hannes Schulz, Hartmut Kaiser

Faculty Publications

Although recent scaling up approaches to train deep neural networks have proven to be effective, the computational intensity of large and complex models, as well as the availability of large-scale datasets require deep learning frameworks to utilize scaling out techniques. Parallelization approaches and distribution requirements are not considered in the primary designs of most available distributed deep learning frameworks and most of them still are not able to perform effective and efficient fine-grained inter-node communication. We present Phylanx that has the potential to alleviate these shortcomings. Phylanx presents a productivity-oriented frontend where user Python code is translated to a futurized …

Characterizing The Biophysical Properties And Origin Of Extracellular Matrix In The Breast Tumor Microenvironment, Connor T. King

LSU Master's Theses

Tumors derived from breast tissue possess the ability to manipulate and permanently alter their surrounding tissue. Studies demonstrate that tissues surrounding breast tumors have differences in secreted factors as well as extracellular matrix (ECM) deposition and structure. However, some fundamental gaps exist within this paradigm: specifically, what exacerbates this transformation and are these changes maintained between the subtypes of breast tumors? Therefore, a targeted evaluation of the effects of the tumor on the stromal microenvironment in a subtype specific manner will be invaluable. To determine if tumor aggressiveness and subtype differentially regulate the tumor microenvironment, a model must be constructed …