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Wind Power Prediction Using Ensemble Learning-Based Models, Junho Lee, Wu Wang, Fouzi Harrou, Ying Sun Jan 2020

Wind Power Prediction Using Ensemble Learning-Based Models, Junho Lee, Wu Wang, Fouzi Harrou, Ying Sun

Faculty Publications

Wind power is one of the most potential energies and the major available renewable energy sources. Precisely predicting wind power production is essential for the management and the integration of wind power in a smart grid. The goal of this study is to predict wind power production with sufficient accuracy based on various factors using ensemble learning-based methods that consider the time-dependent nature of the wind power measurements. Essentially, the ensemble learning methods combine multiple learners to obtain an enhanced prediction performance in comparison to conventional standalone learners. In addition, they reduce the overall prediction error and have the capacity …

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Averages Along The Primes: Improving And Sparse Bounds, Rui Han, Ben Krause, Michael T. Lacey, Fan Yang Jan 2020

Averages Along The Primes: Improving And Sparse Bounds, Rui Han, Ben Krause, Michael T. Lacey, Fan Yang

Faculty Publications

Consider averages along the prime integers P given by ANf(x)=N-1 p:p≤N(logp)f(x-p). A N f(x) = {N-1*∑ ∈ P:p ≤ N} (p)f(x-p).} These averages satisfy a uniform scale-free p-improving estimate. For all 1 < p < 2, there is a constant Cp so that for all integer N and functions f supported on [0, N], there holds N-1/p′-ANf-p′≤CpN-1/p-f-p. {N-1/p'ANf |ℓ p'≤ C_p N-1p| f |ℓ p. The maximal function A∗f = supN|AN f | satisfies (p, p) sparse bounds for all 1 < p < 2. The latter are the natural variants of the scale-free bounds. As a corollary, A∗ is bounded on Ap(w), for all weights w in the Muckenhoupt Ap class. No prior weighted inequalities for A∗ were known.

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The 2-Factor Polynomial Detects Even Perfect Matchings, Scott Baldridge, Adam M. Lowrance, Ben Mccarty Jan 2020

The 2-Factor Polynomial Detects Even Perfect Matchings, Scott Baldridge, Adam M. Lowrance, Ben Mccarty

Faculty Publications

In this paper, we prove that the 2-factor polynomial, an invariant of a planar trivalent graph with a perfect matching, counts the number of 2-factors that contain the perfect matching as a subgraph. Consequently, we show that the polynomial detects even perfect matchings.

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Minimal Flag Triangulations Of Lower-Dimensional Manifolds, Christin Bibby, Andrew Odesky, Mengmeng Wang, Shuyang Wang, Ziyi Zhang, Hailun Zheng Jan 2020

Minimal Flag Triangulations Of Lower-Dimensional Manifolds, Christin Bibby, Andrew Odesky, Mengmeng Wang, Shuyang Wang, Ziyi Zhang, Hailun Zheng

Faculty Publications

We prove the following results on flag triangulations of 2-and 3-manifolds. In dimension 2, we prove that the vertex-minimal flag triangulations of ℝP and S × S have 11 and 12 vertices, respectively. In general, we show that 8 + 3k (resp. 8+4k) vertices suffice to obtain a flag triangulation of the connected sum of k copies of ℝP (resp. S × S ). In dimension 3, we describe an algorithm based on the Lutz–Nevo theorem which provides supporting computational evidence for the following generalization of the Charney–Davis conjecture: for any flag 3-manifold, γ := f −5 f +16 ≥ …

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Some Numeric Hypergeometric Supercongruences, Ling Long Jan 2020

Some Numeric Hypergeometric Supercongruences, Ling Long

Faculty Publications

In this article, we list a few hypergeometric supercongruence conjectures based on two evaluation formulas of Whipple and numeric data computed using Magma and Sagemath.

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Circuit-Difference Matroids, George Drummond, James Oxley, Kevin Grace, Tara Fife Jan 2020

Circuit-Difference Matroids, George Drummond, James Oxley, Kevin Grace, Tara Fife

Faculty Publications

One characterization of binary matroids is that the symmetric difference of every pair of intersecting circuits is a disjoint union of circuits. This paper considers circuit-difference matroids, that is, those matroids in which the symmetric difference of every pair of intersecting circuits is a single circuit. Our main result shows that a connected regular matroid is circuit-difference if and only if it contains no pair of skew circuits. Using a result of Pfeil, this enables us to explicitly determine all regular circuit-difference matroids. The class of circuit-difference matroids is not closed under minors, but it is closed under series minors. …

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On Density-Critical Matroids, Rutger Campbell, Kevin Grace, James Oxley, Geoff Whittle Jan 2020

On Density-Critical Matroids, Rutger Campbell, Kevin Grace, James Oxley, Geoff Whittle

Faculty Publications

For a matroid M having m rank-one flats, the density d(M) isr(M)m unless m = 0, in which case d(M) = 0. A matroid is density-critical if all of its proper minors of non-zero rank have lower density. By a 1965 theorem of Edmonds, a matroid that is minor-minimal among simple matroids that cannot be covered by k independent sets is density-critical. It is straightforward to show that U1,k+1 is the only minor-minimal loopless matroid with no covering by k independent sets. We prove that there are exactly ten minor-minimal simple obstructions to a matroid being able to be covered …

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Context-Aware Design Of Cyber-Physical Human Systems (Cphs), Supratik Mukhopadhyay, Subhajit Sidhanta, Arnab Ganguly, Qun Liu, Edward Collier, Yimin Zhu, Ravindra Gudishala, Chanachok Chokwitthaya, Robert Dibiano, Alimire Nabijiang, Sanaz Saeidi Jan 2020

Context-Aware Design Of Cyber-Physical Human Systems (Cphs), Supratik Mukhopadhyay, Subhajit Sidhanta, Arnab Ganguly, Qun Liu, Edward Collier, Yimin Zhu, Ravindra Gudishala, Chanachok Chokwitthaya, Robert Dibiano, Alimire Nabijiang, Sanaz Saeidi

Faculty Publications

Recently, it has been widely accepted by the research community that interactions between humans and cyber-physical infrastructures have played a significant role in determining the performance of the latter. The existing paradigm for designing cyber-physical systems for optimal performance focuses on developing models based on historical data. The impacts of context factors driving human system interaction are challenging and are difficult to capture and replicate in existing design models. As a result, many existing models do not or only partially address those context factors of a new design owing to the lack of capabilities to capture the context factors. This …

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Additive Schwarz Preconditioners For A State Constrained Elliptic Distributed Optimal Control Problem Discretized By A Partition Of Unity Method, Susanne C. Brenner, Christopher B. Davis, Li Yeng Sung Jan 2020

Additive Schwarz Preconditioners For A State Constrained Elliptic Distributed Optimal Control Problem Discretized By A Partition Of Unity Method, Susanne C. Brenner, Christopher B. Davis, Li Yeng Sung

Faculty Publications

The minimization problem (2) is discretized in [4] by a partition of unity method (PUM). The goal of this paper is to use the ideas in [5] for an obstacle problem of clamped Kirchhoff plates to develop preconditioners for the discrete problems in [4].

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A Balancing Domain Decomposition By Constraints Preconditioner For A C0 Interior Penalty Method, Susanne C. Brenner, Eun Hee Park, Li Yeng Sung, Kening Wang Jan 2020

A Balancing Domain Decomposition By Constraints Preconditioner For A C0 Interior Penalty Method, Susanne C. Brenner, Eun Hee Park, Li Yeng Sung, Kening Wang

Faculty Publications

Consider the following weak formulation of a fourth order problem on a bounded polygonal domain Ω in R : 2

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Finite Element Methods For One Dimensional Elliptic Distributed Optimal Control Problems With Pointwise Constraints On The Derivative Of The State, S. C. Brenner, L. Y. Sung, W. Wollner Jan 2020

Finite Element Methods For One Dimensional Elliptic Distributed Optimal Control Problems With Pointwise Constraints On The Derivative Of The State, S. C. Brenner, L. Y. Sung, W. Wollner

Faculty Publications

We investigate C finite element methods for one dimensional elliptic distributed optimal control problems with pointwise constraints on the derivative of the state formulated as fourth order variational inequalities for the state variable. For the problem with Dirichlet boundary conditions, we use an existing H52-ϵ regularity result for the optimal state to derive O(h12-ϵ) convergence for the approximation of the optimal state in the H norm. For the problem with mixed Dirichlet and Neumann boundary conditions, we show that the optimal state belongs to H under appropriate assumptions on the data and obtain O(h) convergence for the approximation of the …

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Additive Schwarz Preconditioners For A Localized Orthogonal Decomposition Method, Susanne C. Brenner, José C. Garay, Li Yeng Sung Jan 2020

Additive Schwarz Preconditioners For A Localized Orthogonal Decomposition Method, Susanne C. Brenner, José C. Garay, Li Yeng Sung

Faculty Publications

We investigate a variant of the localized orthogonal decomposition method (Henning and Peterseim, [Multiscale Model. Simul., 11 (2013), pp. 1149 1175] and Malqvist and Peterseim, [Math. Comp., 83 (2014), pp. 2583 2603]) for elliptic problems with rough coefficients. The construction of the basis of the multiscale finite element space is based on domain decomposition techniques, which is motivated by the recent work of Kornhuber, Peterseim, and Yserentant [Math. Comp., 87 (2018), pp. 2765 2774]. We also design and analyze additive Schwarz domain decomposition preconditioners for the resulting discrete problems.

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P 1 Finite Element Methods For An Elliptic Optimal Control Problem With Pointwise State Constraints, Susanne C. Brenner, Li Yeng Sung, Joscha Gedicke Jan 2020

P 1 Finite Element Methods For An Elliptic Optimal Control Problem With Pointwise State Constraints, Susanne C. Brenner, Li Yeng Sung, Joscha Gedicke

Faculty Publications

We present theoretical and numerical results for two P finite element methods for an elliptic distributed optimal control problem on general polygonal/polyhedral domains with pointwise state constraints. 1

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Stabilization For A Chain Of Saturating Integrators Arising In The Visual Landing Of Aircraft With Sampling, Laurent Burlion, Michael Malisoff, Frédéric Mazenc Jan 2020

Stabilization For A Chain Of Saturating Integrators Arising In The Visual Landing Of Aircraft With Sampling, Laurent Burlion, Michael Malisoff, Frédéric Mazenc

Faculty Publications

We provide a new output feedback control design for a chain of saturating integrators with imprecise output measurements where the outputs can also contain delays and sampling. Using a backstepping approach that leads to pointwise delays in the control and a dynamic extension, we prove input-to-state stability using a new dynamic extension approach. We utilize our main result to solve a problem in the visual landing of aircraft in the glide phase in the presence of delayed and sampled image processing.

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Determination Of Clinical Parameters Sensitive To Functional Voice Disorders Applying Boosted Decision Stumps, Patrick Schlegel, Andreas M. Kist, Marion Semmler, Michael Dollinger, Melda Kunduk, Stephan Durr, Anne Schutzenberger Jan 2020

Determination Of Clinical Parameters Sensitive To Functional Voice Disorders Applying Boosted Decision Stumps, Patrick Schlegel, Andreas M. Kist, Marion Semmler, Michael Dollinger, Melda Kunduk, Stephan Durr, Anne Schutzenberger

Faculty Publications

Background: Various voice assessment tools, such as questionnaires and aerodynamic voice characteristics, can be used to assess vocal function of individuals. However, not much is known about the best combinations of these parameters in identification of functional dysphonia in clinical settings. Methods: This study investigated six scores from clinically commonly used questionnaires and seven acoustic parameters. 514 females and 277 males were analyzed. The subjects were divided into three groups: one healthy group (N01) (49 females, 50 males) and two disordered groups with perceptually hoarse (FD23) (220 females, 96 males) and perceptually not hoarse (FD01) (245 females, 131 males) sounding …

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Emerging Infectious Disease, The Household Built Environment Characteristics, And Urban Planning: Evidence On Avian Influenza In Vietnam, James H. Spencer, Melissa L. Finucane, Jefferson M. Fox, Sumeet Saksena, Nargis Sultana Jan 2020

Emerging Infectious Disease, The Household Built Environment Characteristics, And Urban Planning: Evidence On Avian Influenza In Vietnam, James H. Spencer, Melissa L. Finucane, Jefferson M. Fox, Sumeet Saksena, Nargis Sultana

Faculty Publications

Recent concerns with pandemic outbreaks of human disease and their origins in animal populations have ignited concerns regarding connections between Emerging Infectious Diseases (EID) and development. As disasters, health, and infectious disease become part of planning concern (Matthew & McDonald, 2007), greater focus on household infrastructure and EID disease outbreaks among poultry is warranted. Following Spencer (2013), this study examines the relationship between the mix of household-scale water supplies, sanitation systems, and construction materials, and Highly Pathogenic Avian Influenza (HPAI) among poultry in a developing country: Vietnam. Findings of our multivariate logistic regressions suggest that a non-linear, Kuznets-shaped urban transition …

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Consumer Perception Of Extruded Snacks Containing Brown Rice And Dried Mushroom, Benjarat Tepsongkroh, Kamolwan Jangchud, Anuvat Jangchud, Pitchayapat Chonpracha, Ryan Ardoin, Witoon Prinyawiwatkul Jan 2020

Consumer Perception Of Extruded Snacks Containing Brown Rice And Dried Mushroom, Benjarat Tepsongkroh, Kamolwan Jangchud, Anuvat Jangchud, Pitchayapat Chonpracha, Ryan Ardoin, Witoon Prinyawiwatkul

Faculty Publications

Effects of mushroom type, seasoning and health benefit information (HBI) on consumers’ saltiness expectation, sensory liking, elicited emotions and purchase intent (PI) of extruded snacks were investigated. Five snacks were evaluated: straw mushroom (Volvariella volvacea) extrudates without (SME) or with seasoning (SMES), phoenix mushroom (Pleurotus pulmonarius) extrudates without (PME) or with seasoning (PMES), and the control without mushroom and seasoning. Hedonic scores and positive emotions were generally higher for seasoned mushroom-containing snacks (SMES and PMES) with 65% and 75.83% of consumers reporting willingness to purchase, respectively, after receiving HBI. Bored, interested and satisfied were identified as significant emotional predictors for …

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Reducible Fermi Surfaces For Non-Symmetric Bilayer Quantum-Graph Operators, Stephen P. Shipman Jan 2020

Reducible Fermi Surfaces For Non-Symmetric Bilayer Quantum-Graph Operators, Stephen P. Shipman

Faculty Publications

This work constructs a class of non-symmetric periodic Schrödinger operators on metric graphs (quantum graphs) whose Fermi, or Floquet, surface is reducible. The Floquet surface at an energy level is an algebraic set that describes all complex wave vectors admissible by the periodic operator at the given energy. The graphs in this study are obtained by coupling two identical copies of a periodic quantum graph by edges to form a bilayer graph. Reducibility of the Floquet surface for all energies ensues when the coupling edges have potentials belonging to the same asymmetry class. The notion of asymmetry class is defined …

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Toeplitz Operators On The Domain (Formula Presented)- With (Formula Presented)-Invariant Symbols, Matthew Dawson, Gestur Ólafsson, Raul Quiroga-Barranco Jan 2020

Toeplitz Operators On The Domain (Formula Presented)- With (Formula Presented)-Invariant Symbols, Matthew Dawson, Gestur Ólafsson, Raul Quiroga-Barranco

Faculty Publications

Let D be the irreducible bounded symmetric domain of 2 × 2 complex matrices that satisfy ZZ* < I2. The biholomorphism group of D is realized by U(2, 2) with isotropy at the origin given by U(2) ×U(2). Denote by (Formula Presented) the subgroup of diagonal matrices in U(2). We prove that the set of (Formula Presented)-invariant essentially bounded symbols yield Toeplitz operators that generate commutative C*-algebras on all weighted Bergman spaces over D. Using tools from representation theory, we also provide an integral formula for the spectra of these Toeplitz operators.

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New Atomic Decompositions Of Bergman Spaces On Bounded Symmetric Domains, Jens Gerlach Christensen, Gestur Ólafsson Jan 2020

New Atomic Decompositions Of Bergman Spaces On Bounded Symmetric Domains, Jens Gerlach Christensen, Gestur Ólafsson

Faculty Publications

We provide a large family of atoms for Bergman spaces on irreducible bounded symmetric domains. The atomic decompositions are derived using the holomorphic discrete series representations for the domain, and the approach is inspired by recent advances in wavelet and coorbit theory. Our results vastly generalize previous work by Coifman and Rochberg. Their atoms correspond to translates of a constant function at a discrete subset of the automorphism group of the domain. In this paper we show that atoms can be obtained as translates of any holomorphic function with rapidly decreasing coefficients (including polynomials). This approach also settles the relation …

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Symmetric Spaces With Dissecting Involutions, K. H. Neeb, G. Ólafsson Jan 2020

Symmetric Spaces With Dissecting Involutions, K. H. Neeb, G. Ólafsson

Faculty Publications

An involutive diffeomorphism σ of a connected smooth manifold M is called dissecting if the complement of its fixed point set is not connected. Dissecting involutions on a complete Riemannian manifold are closely related to constructive quantum field theory through the work of Dimock and Jaffe/Ritter on the construction of reflection positive Hilbert spaces. In this article we classify all pairs (M, σ), where M is an irreducible connected symmetric space, not necessarily Riemannian, and σ is a dissecting involutive automorphism. In particular, we show that the only irreducible, connected and simply connected Riemannian symmetric spaces with dissecting isometric involutions …

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Pollution And Polluter Pays, Aaron Lercher Jan 2020

Pollution And Polluter Pays, Aaron Lercher

Faculty Publications

No abstract provided.

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Operational Planning Of Supply Chains In A Production And Distribution Center With Just-In-Time Delivery, Pablo Biswas, Bhaba Sarker Jan 2020

Operational Planning Of Supply Chains In A Production And Distribution Center With Just-In-Time Delivery, Pablo Biswas, Bhaba Sarker

Faculty Publications

Purpose: A supply chain consists of raw material suppliers, manufacturers and retailers where inventory of raw materials and finished goods are involved, respectively. Therefore, it is important to find optimal solutions, which are beneficial for both supplier, manufacturer and retailer.

Design/methodology/approach: This research focuses on a semi-continuous manufacturing facility by assuming that the production of succeeding cycle starts immediately after the production of preceding cycle. In reality, the inventory of a supply chain system may not be completely empty. A number of products may be left over after the deliveries are made. These leftover inventories are added to the next …

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Role Of Geometric Shape In Chiral Optics, Philipp Gutsche, Xavier Garcia-Santiago, Philipp Immanuel Schneider, Kevin M. Mcpeak, Manuel Nieto-Vesperinas, Sven Burger Jan 2020

Role Of Geometric Shape In Chiral Optics, Philipp Gutsche, Xavier Garcia-Santiago, Philipp Immanuel Schneider, Kevin M. Mcpeak, Manuel Nieto-Vesperinas, Sven Burger

Faculty Publications

The distinction of chiral and mirror symmetric objects is straightforward from a geometrical point of view. Since the biological as well as the optical activity of molecules strongly depend on their handedness, chirality has recently attracted high interest in the field of nano-optics. Various aspects of associated phenomena including the influences of internal and external degrees of freedom on the optical response have been discussed. Here, we propose a constructive method to evaluate the possibility of observing any chiral response from an optical scatterer. Based on solely the T-matrix of one enantiomer, planes of minimal chiral response are located and …

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Reachable Sets For Safe, Real-Time Manipulator Trajectory Design, Patrick Holmes, Shreyas Kousik, Bohao Zhang, Daphna Raz, Corina Barbalata, Matthew Johnson-Roberson, Ram Vasudevan Jan 2020

Reachable Sets For Safe, Real-Time Manipulator Trajectory Design, Patrick Holmes, Shreyas Kousik, Bohao Zhang, Daphna Raz, Corina Barbalata, Matthew Johnson-Roberson, Ram Vasudevan

Faculty Publications

For robotic arms to operate in arbitrary environments, especially near people, it is critical to certify the safety of their motion planning algorithms. However, there is often a trade-o↵ between safety and real-time performance; one can either carefully design safe plans, or rapidly generate potentially-unsafe plans. This work presents a receding-horizon, real-time trajectory planner with safety guarantees, called ARMTD (Au-tonomous Reachability-based Manipulator Trajectory Design). The method first computes (o✏ine) a reachable set of parameterized trajectories for each joint of an arm. Each trajectory includes a fail-safe maneuver (braking to a stop). At runtime, in each receding-horizon planning iteration, ARMTD constructs …

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Peak Pressures On Low Rise Buildings: Cfd With Les Versus Full Scale And Wind Tunnel Measurements, Aly Mousaad Aly, Hamzeh Gol-Zaroudi Jan 2020

Peak Pressures On Low Rise Buildings: Cfd With Les Versus Full Scale And Wind Tunnel Measurements, Aly Mousaad Aly, Hamzeh Gol-Zaroudi

Faculty Publications

This paper focuses on the processes of wind flow in the atmospheric boundary layer, to produce realistic full-scale pressures for the design of low-rise buildings. CFD with LES turbulence closure is implemented on a scale 1:1 prototype building. A proximity study was executed computationally in CFD with LES that suggests new recommendations on the computational domain size, in front of a building model, apart from common RANS-based guidelines (e.g. COST and AIJ). Our findings suggest a location of the test building, different from existing guidelines, and the inflow boundary proximity influences pressure correlation and reproduction of peak loads. The CFD …

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Wettability Effects On Primary Drainage Mechanisms And Napl Distribution: A Pore-Scale Study, Ian L. Molnar, Jason I. Gerhard, Clinton S. Willson, Denis M. O'Carroll Jan 2020

Wettability Effects On Primary Drainage Mechanisms And Napl Distribution: A Pore-Scale Study, Ian L. Molnar, Jason I. Gerhard, Clinton S. Willson, Denis M. O'Carroll

Faculty Publications

The pore-scale processes governing water drainage behavior in porous media have implications for geoscience multiphase scenarios including carbon capture and storage, contaminant site remediation, oil recovery, and vadose zone processes. However, few studies report directly observed pore-scale water drainage phenomena in 3-D soils. This knowledge gap limits our ability to verify assumptions underlying existing models and develop optimal solutions. This paper utilizes synchrotron X-ray microtomography to present an experimental pore-scale examination of nonaqueous phase liquid (NAPL)/water distribution along a primary drainage front as dense NAPL was injected upward into water wetting (WW) and intermediate wetting (IW) sand-packed columns. Pore-network structures …

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First Person: The Pandemic's Silver Lining: Real Talk For Future Teachers, J Hipp Jan 2020

First Person: The Pandemic's Silver Lining: Real Talk For Future Teachers, J Hipp

Faculty Publications

When the COVID-19 pandemic closed her university campus, Jamie Hipp had to move her popular arts integration class for preservice teachers to a virtual format. She was surprised to learn that her students wanted more than regular sessions during their scheduled class times; they wanted additional opportunities for real teacher talk about going on interviews, setting up a classroom, and other practical matters that weren't being covered in their preservice program. Hipp set up a series of virtual sessions on topics of interest to students, in addition to regular class sessions. The sessions went so well that Hipp intends to …

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Measurement Of Neutrino And Antineutrino Neutral-Current Quasielasticlike Interactions On Oxygen By Detecting Nuclear Deexcitation Γ Rays, K. Abe, R. Akutsu, A. Ali, C. Alt, C. Andreopoulos, L. Anthony, M. Antonova, S. Aoki, A. Ariga, Y. Ashida, E. T. Atkin, Y. Awataguchi, S. Ban, M. Barbi, G. J. Barker, G. Barr, C. Barry, M. Batkiewicz-Kwasniak, A. Beloshapkin, F. Bench, V. Berardi, S. Berkman, L. Berns, S. Bhadra, S. Bienstock, A. Blondel, S. Bolognesi, B. Bourguille Dec 2019

Measurement Of Neutrino And Antineutrino Neutral-Current Quasielasticlike Interactions On Oxygen By Detecting Nuclear Deexcitation Γ Rays, K. Abe, R. Akutsu, A. Ali, C. Alt, C. Andreopoulos, L. Anthony, M. Antonova, S. Aoki, A. Ariga, Y. Ashida, E. T. Atkin, Y. Awataguchi, S. Ban, M. Barbi, G. J. Barker, G. Barr, C. Barry, M. Batkiewicz-Kwasniak, A. Beloshapkin, F. Bench, V. Berardi, S. Berkman, L. Berns, S. Bhadra, S. Bienstock, A. Blondel, S. Bolognesi, B. Bourguille

Faculty Publications

Neutrino- A nd antineutrino-oxygen neutral-current quasielasticlike interactions are measured at Super-Kamiokande using nuclear deexcitation γ rays to identify signal-like interactions in data from a 14.94(16.35)×1020 protons-on-target exposure of the T2K neutrino (antineutrino) beam. The measured flux-averaged cross sections on oxygen nuclei are âσν-NCQEâ

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Characterization Of An Extensive Interface On Vitronectin For Binding To Plasminogen Activator Inhibitor-1: Adoption Of Structure In An Intrinsically Disordered Region, Letitia O. Puster, Christopher B. Stanley, Vladimir N. Uversky, Joseph E. Curtis, Susan Krueger, Yuzhuo Chu, Cynthia B. Peterson Dec 2019

Characterization Of An Extensive Interface On Vitronectin For Binding To Plasminogen Activator Inhibitor-1: Adoption Of Structure In An Intrinsically Disordered Region, Letitia O. Puster, Christopher B. Stanley, Vladimir N. Uversky, Joseph E. Curtis, Susan Krueger, Yuzhuo Chu, Cynthia B. Peterson

Faculty Publications

Copyright © 2019 American Chemical Society. Small-angle neutron scattering (SANS) measurements were pursued to study human vitronectin, a protein found in tissues and the circulation that regulates cell adhesion/migration and proteolytic cascades that govern hemostasis and pericellular proteolysis. Many of these functions occur via interactions with its binding partner, plasminogen activator inhibitor-1 (PAI-1), the chief inhibitor of proteases that lyse and activate plasminogen. We focused on a region of vitronectin that remains uncharacterized from previous X-ray scattering, nuclear magnetic resonance, and computational modeling approaches and which we propose is involved in binding to PAI-1. This region, which bridges the N-terminal …

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