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Optimization Of Mechanical Properties At The Infarct Border Zone, Kaushik Sunder

LSU Master's Theses

A myocardial infarction (MI) occurs every 39 seconds in the United States. As of 2016, an estimated 550,000 new and 200,000 recurrent episodes of myocardial infarction (MI) occur each year in the United States was. Infarction is often distinguished by a considerable decrease in wall thickness and an increase in heart size or left ventricular volume. This behavior happens when there is a prolonged lack of blood flow, usually due to damage or clotting, which causes cardiomyocytes to die (CMs). The development of non-contractile infarct scarring is the primary pathophysiology of MI. While the infarct scar prevents myocardial rupture during …

Initial Investigations Into Tools For Phytoremediation Of Lead From Urban And Suburban Landscapes, Michael Taylor Bryant

LSU Master's Theses

Lead is a pervasive and ongoing problem in the landscape, especially in urban and suburban areas where historic use of tetraethyl lead gasoline and leaded paint has increased background amounts to dangerous levels. One method to solve this problem is the use of hyperaccumulator plant species, capable of concentrating over 1000 ppm Pb into their tissues. This is a slow process, even with hyperaccumulators, so the use of amendments to improve Pb solubility has gained popularity, though with mixed results. This study examined Trachelospermum asiaticum, Ardisia japonica, and Ophiopogon japonicus, three common landscape groundcovers used in Louisiana, …

Applying Spatial Video Geonarratives And Physiological Measurements To Explore Perceived Safety In Baton Rouge, Louisiana, Alina Ristea, Michael Leitner, Bernd Resch, Judith Stratmann

Faculty Publications

Spatial crime analysis, together with perceived (crime) safety analysis have tremendously benefitted from Geographic Information Science (GISc) and the application of geospatial technology. This research study discusses a novel methodological approach to document the use of emerg-ing geospatial technologies to explore perceived urban safety from the lenses of fear of crime or crime perception in the city of Baton Rouge, USA. The mixed techniques include a survey, spatial video geonarrative (SVG) in the field with study participants, and the extraction of moments of stress (MOS) from biosensing wristbands. This study enrolled 46 participants who completed geonarratives and MOS detection. A …

Effects Of Caloric Restriction On Human Physiological, Psychological, And Behavioral Outcomes: Highlights From Calerie Phase 2, James L. Dorling, Stephan Van Vliet, Kim M. Huffman, William E. Kraus, Manjushri Bhapkar, Carl F. Pieper, Tiffany Stewart, Sai Krupa Das, Susan B. Racette, Susan B. Roberts, Eric Ravussin, Leanne M. Redman, Corby K. Martin

Clinical Research Faculty Publications

Caloric restriction (CR) is a strategy that attenuates aging in multiple nonhuman species. The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trials are part of a research program aiming to test the effects of CR on aging and longevity biomarkers in humans. Building on CALERIE phase 1, CALERIE phase 2 (CALERIE 2) was the largest study to date to assess sustained CR in healthy humans without obesity. In a 24-month randomized controlled trial comprising 218 participants at baseline, CALERIE 2 showed that moderate CR, 11.9% on average, induced improvements in aging-related biomarkers without adversely affecting psychological …

Adipose Depot-Specific Effects Of 16 Weeks Of Pioglitazone On In Vivo Adipogenesis In Women With Obesity: A Randomised Controlled Trial, Ursula White, Mark D. Fitch, Robbie A. Beyl, Marc K. Hellerstein, Eric Ravussin

Clinical Research Faculty Publications

Aims/hypothesis: In vitro and rodent studies suggest that pioglitazone, a thiazolidinedione, can promote adipogenesis in adipose tissue (AT); however, there is a lack of in vivo studies in humans to support these findings. The objectives of this randomised, placebo-controlled, parallel-arm trial were to test if pioglitazone stimulates in vivo adipogenesis in the subcutaneous adipose tissue depots and if these measures were related to metabolic health outcomes in women with obesity. Methods: Forty-one healthy women with obesity (20 black; 21 white; 29 ± 6 years; BMI 32.0 ± 1.7 kg/m2; 44.0 ± 3.6% body fat) were randomised to consume 30 mg/day …

Beyond Weight Loss: Current Perspectives On The Impact Of Calorie Restriction On Healthspan And Lifespan, Maryam Kebbe, Joshua R. Sparks, Emily W. Flanagan, Leanne M. Redman

Clinical Research Faculty Publications

Introduction: Changes to mental, physical, and physiological functions drive the complex processes underlying the variable progression of human aging. Nutritional interventions are one of the most promising non-pharmacological therapeutics to attenuate aging in humans. This narrative review aims to describe the implications of moderate and prolonged calorie restriction (CR) in healthy adults without obesity that occur beyond weight loss. Areas covered: Findings from CR studies, such as the CALERIE (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy) trials, the most rigorous trials to date examining a prolonged 25% CR, are described. The main areas covered include; changes to …

Energy Expenditure And Macronutrient Oxidation In Response To An Individualized Nonshivering Cooling Protocol, Guillermo Sanchez-Delgado, Juan M.A. Alcantara, Francisco M. Acosta, Borja Martinez-Tellez, Francisco J. Amaro-Gahete, Elisa Merchan-Ramirez, Marie Löf, Idoia Labayen, Eric Ravussin, Jonatan R. Ruiz

Clinical Research Faculty Publications

Objective: This study aimed to describe the energy expenditure (EE) and macronutrient oxidation response to an individualized nonshivering cold exposure in young healthy adults. Methods: Two different groups of 44 (study 1: 22.1 [SD 2.1] years old, 25.6 [SD 5.2] kg/m2, 34% men) and 13 young healthy adults (study 2: 25.6 [SD 3.0] years old, 23.6 [SD 2.4] kg/m2, 54% men) participated in this study. Resting metabolic rate (RMR) and macronutrient oxidation rates were measured by indirect calorimetry under fasting conditions in a warm environment (for 30 minutes) and in mild cold conditions (for 65 minutes, with the individual wearing …

Integrative And Quantitative Bioenergetics: Design Of A Study To Assess The Impact Of The Gut Microbiome On Host Energy Balance, Karen D. Corbin, Rosa Krajmalnik-Brown, Elvis A. Carnero, Christopher Bock, Rita Emerson, Bruce E. Rittmann, Andrew K. Marcus, Taylor Davis, Blake Dirks, Zehra Esra Ilhan, Catherine Champagne, Steven R. Smith

Population and Public Health Science Faculty Publications

The literature is replete with clinical studies that characterize the structure, diversity, and function of the gut microbiome and correlate the results to different disease states, including obesity. Whether the microbiome has a direct impact on obesity has not been established. To address this gap, we asked whether the gut microbiome and its bioenergetics quantitatively change host energy balance. This paper describes the design of a randomized crossover clinical trial that combines outpatient feeding with precisely controlled metabolic phenotyping in an inpatient metabolic ward. The target population was healthy, weight-stable individuals, age 18–45 and with a body mass index ≤30 …

Solvation Structures And Dynamics Of Small Molecules: Experimental And Computational Studies Using Carbonyl Vibrational Modes As Probe, Xiaoliu Zhang

LSU Doctoral Dissertations

Solutions are ubiquitous in both the global environment and the human body, and play a significant role in scientific research and industrial production. The structures and dynamics of solutions have been studied for centuries. However, conventional experimental methods, whose intrinsic measuring time is on the order of nanoseconds to microseconds, could not detect the fast dynamics taking place in the solution on the timescale of femto- and pico-second. In this dissertation, the ultrafast two-dimensional infrared (2DIR) spectroscopy was applied to characterize the structure and dynamics in three different types of solutions on the sub-picosecond timescale. Linear Fourier transform infrared spectroscopy …

On Characterizing Quantum Processes And Detectors, Kevin Valson Jacob

LSU Doctoral Dissertations

In 2009, physicists at the National Institute of Standards and Technology in Colorado, Boulder developed what could arguable be called the first rudimentary quantum computer [1]. The past decade has seen unprecedented improvements in quantum information science culminating in the demonstration of quantum supremacy --- that quantum computers can solve problems that are impractical to be solved on the best supercomputers [2]. This remarkable progress necessitates the development of techniques to characterize the quantum devices that are being developed. In my thesis, I will focus on such devices that manipulate and detect light.

In Chapter 1, I will introduce the …

Naringenin Increases Insulin Sensitivity And Metabolic Rate: A Case Study, Navya Murugesan, Kaylee Woodard, Rahul Ramaraju, Frank L. Greenway, Ann A. Coulter, Candida J. Rebello

Clinical Research Faculty Publications

Our studies in primary human adipocytes show that naringenin, a citrus flavonoid, increases oxygen consumption rate and gene expression of uncoupling protein 1 (UCP1), glucose transporter type 4, and carnitine palmitoyltransferase 1β (CPT1β). We investigated the safety of naringenin, its effects on metabolic rate, and blood glucose and insulin responses in a single female subject with diabetes. The subject ingested 150 mg naringenin from an extract of whole oranges standardized to 28% naringenin three times/day for 8 weeks, and maintained her usual food intake. Body weight, resting metabolic rate, respiratory quotient, and blood chemistry panel including glucose, insulin, and safety …

Sleep Characteristics And Health-Related Quality Of Life In 9- To 11-Year-Old Children From 12 Countries, Qian Xiao, Jean Philippe Chaput, Timothy Olds, Mikael Fogelholm, Gang Hu, Estelle V. Lambert, Carol Maher, Jose Maia, Vincent Onywera, Olga L. Sarmiento, Martyn Standage, Mark S. Tremblay, Catrine Tudor-Locke, Peter T. Katzmarzyk

Population and Public Health Science Faculty Publications

Introduction: Previous studies have linked short sleep duration, poor sleep quality, and late sleep timing with lower health-related quality of life (HRQoL) in children. However, almost all studies relied solely on self-reported sleep information, and most studies were conducted in high-income countries. To address these gaps, we studied both device-measured and self-reported sleep characteristics in relation to HRQoL in a sample of children from 12 countries that vary widely in terms of economic and human development. Methods: The study sample included 6,626 children aged 9-11 years from Australia, Brazil, Canada, China, Colombia, Finland, India, Kenya, Portugal, South Africa, the United …

Improving Natural Product Research Translation: From Source To Clinical Trial, Barbara C. Sorkin, Adam J. Kuszak, Gregory Bloss, Naomi K. Fukagawa, Freddie Ann Hoffman, Mahtab Jafari, Bruce Barrett, Paula N. Brown, Frederic D. Bushman, Steven J. Casper, Floyd H. Chilton, Christopher S. Coffey, Mario G. Ferruzzi, D. Craig Hopp, Mairead Kiely, Daniel Lakens, John B. Macmillan, David O. Meltzer, Marco Pahor, Jeffrey Paul, Kathleen Pritchett-Corning, Sara K. Quinney, Barbara Rehermann, Kenneth D.R. Setchell, Nisha S. Sipes, Jacqueline M. Stephens, D. Lansing Taylor, Hervé Tiriac, Michael A. Walters, Dan Xi, Giovanna Zappalá, Guido F. Pauli

Faculty Publications

© 2019 Federation of American Societies for Experimental Biology While great interest in health effects of natural product (NP) including dietary supplements and foods persists, promising preclinical NP research is not consistently translating into actionable clinical trial (CT) outcomes. Generally considered the gold standard for assessing safety and efficacy, CTs, especially phase III CTs, are costly and require rigorous planning to optimize the value of the information obtained. More effective bridging from NP research to CT was the goal of a September, 2018 transdisciplinary workshop. Participants emphasized that replicability and likelihood of successful translation depend on rigor in experimental design, …

Response Of Liver Metabolic Pathways To Ketogenic Diet And Exercise Are Not Additive, Tai Yu Huang, Felicia R. Goldsmith, Scott E. Fuller, Jacob Simon, Heidi M. Batdorf, Matthew C. Scott, Nabil M. Essajee, John M. Brown, David H. Burk, Christopher D. Morrison, Susan J. Burke, J. Jason Collier, Robert C. Noland

Faculty Publications

© Lippincott Williams & Wilkins. Purpose Studies suggest ketogenic diets (KD) produce favorable outcomes (health and exercise performance); however, most rodent studies have used a low-protein KD, which does not reflect the normal- to high-protein KD used by humans. Liver has an important role in ketoadaptation due to its involvement in gluconeogenesis and ketogenesis. This study was designed to test the hypothesis that exercise training (ExTr) while consuming a normal-protein KD (NPKD) would induce additive/synergistic responses in liver metabolic pathways. Methods Lean, healthy male C57BL/6J mice were fed a low-fat control diet (15.9% kcal protein, 11.9% kcal fat, 72.2% kcal …

Testing The Validity And Reliability Of Electromyography Acquisition Capabilities Of A Wearable Emg Device, Sense3, By Strive, Stanley Smith

LSU Master's Theses

There is a growing demand in the sports world for wearable technology, particularly those with electromyography acquisition capabilities. Electromyography (EMG) is technique for measuring the electrical activity that occurs during muscle contraction and relaxation. Basic practical applications of EMG use in sports include, but are not limited to: measuring activation timing of a muscle, measuring levels of activation, and detecting fatigue. The sports performance company Strive has designed an EMG wearable, called Sense3, that targets the following muscles of the lower limb: Quadriceps, Hamstrings, and Glutes. Sense3 must pass reliability assays to determine the validity of the EMG system in …

Exploring Occupant Behavioral Intentions In Immersive Virtual Environment To Enhance The Design And Engineering Of Sustainable Buildings, Sanaz Saeidi

LSU Doctoral Dissertations

Accurately simulating occupant behavior is essential to improve our understanding about the future energy performance of the buildings. To date, most of the information related to the occupancy behaviors has been gathered through field observations and/or performing experiments within the lab environments. Even though these common data collection methods are effective and reliable for the existing buildings, using such data to project occupant behaviors in other contexts is likely to lead to uncertainties. The most significant theoretical achievement of this dissertation was to provide the future building occupants with thermal experience of non-physically existent environments. In this dissertation occupant behavior …

Influence Of Hydration Status On Running Performance And Makers Of Psychological And Physiological Stress In High School Cross Country Runners, Joshua Granger

LSU Master's Theses

Adequate hydration is an important attribute to an individual’s health and wellbeing. This is highlighted in athletic populations, who are at great risk for hypohydration, regardless of age, sex, and sport. The rampant hypohydration observed in athletes is present at all levels of competition, from professional athletes, with access to substantial monetary and nutrition support to division 3 and recreational athletes who often face monetary challenges. This trend continues to trickle down to lower levels of competition, such as high school, where athletes often practice and compete in dehydrated states. Practicing in these hypohydrated states can cause health issues such …

The Rhetoric Of Sickle Cell Anemia, Raquel Mcfarland Robvais

LSU Doctoral Dissertations

My dissertation examines the rhetorical treatment of sickle cell anemia as synecdoche, representing a preoccupation with racialized discourses of disease and the affective registers manifested in public life. From its inception SCA has taken on cultural meanings to satisfy ideological arguments about the nature of black bodies.

It has been appropriated to create “categories of difference and belonging” (Schramm et al). I examine how SCA is gathered by rhetors to serve varying ideological purposes and cultural communities. It is utilized to invite different readings that conceptualize the black body as an object of scientific experimentation, as an agent for resistance …

Naringenin Promotes Thermogenic Gene Expression In Human White Adipose Tissue, Candida J. Rebello, Frank L. Greenway, Frank H. Lau, Yuan Lin, Jacqueline M. Stephens, William D. Johnson, Ann A. Coulter

Faculty Publications

© 2018 The Obesity Society Objective: Naringenin, a citrus flavonoid, prevents diet-induced weight gain and improves glucose and lipid metabolism in rodents. There is evidence that naringenin activates brown fat and increases energy expenditure in mice, but little is known about its effects in humans. The goal of this study was to examine the effects of naringenin on energy expenditure in adipose tissue. Methods: Human white adipocyte cultures (hADSC) and abdominal subcutaneous adipose tissue (pWAT) were treated with naringenin for 7 to 14 days. Expression (quantitative real-time polymerase chain reaction, immunoblotting) of candidate genes involved in thermogenesis and glucose metabolism …

Comparison Of Thermally Actuated Retro-Diels-Alder Release Groups For Nanoparticle Based Nucleic Acid Delivery, Mohammad Abu-Laban, Raju R. Kumal, Jonathan Casey, Jeff Becca, Daniel Lamaster, Carlos N. Pacheco, Dan G. Sykes, Lasse Jensen, Louis H. Haber, Daniel J. Hayes

Faculty Publications

© 2018 Elsevier Inc. The present study explores alternate pericyclic chemistries for tethering amine-terminal biomolecules onto silver nanoparticles. Employing the versatile tool of the retro-Diels-Alder (rDA) reaction, three thermally-labile cycloadducts are constructed that cleave at variable temperature ranges. While the reaction between furan and maleimide has widely been reported, the current study also evaluates the reverse reaction kinetics between thiophene-maleimide, and pyrrole-maleimide cycloadducts. Density Functional Theorem (DFT) calculations used to model and plan the experiments, predict energy barriers for the thiophene-maleimide reverse reaction to be greatest, and the pyrrole-maleimide barriers the lowest. Based on the computational analyses, it is projected …

Louisiana Urban And Suburban Homeowners’ Fertilizer Management Behavioral Beliefs, Intentions, And Past Behaviors, Natalie Levy

LSU Doctoral Dissertations

Nutrient runoff of nitrogen and phosphorus from improper lawn and landscape fertilization practices contributes to water quality issues within the Mississippi River drainage basin and the Northern Gulf of Mexico (NRC, 2009a; Robbins & Birkenholtz, 2003). The implementation of fertilizer best management practices has become a critical strategy for reducing nutrient runoff (Carey et al., 2012a; Carey et al., 2013; U.S. EPA, 2005). The purpose of this study was to determine if relationships exist among selected perceptual measures regarding home lawn and landscape fertilizer management practices among Louisiana urban and suburban homeowners. Ajzen’s (1991) Theory of Planned Behavior (TPB) was …

Geometric Design, John Marceaux

Honors Capstones

No abstract provided.

Nanostructured Materials Derived From Metal-Organic Frameworks For Energy And Environmental Applications, Zhiqiang Xie

LSU Doctoral Dissertations

Nowadays, energy and environmental issues have become the top priority among a series of global issues. Fossil fuels as the dominant source are depleted fast and usually lead to some environmental problems. Heavy metal pollution has posed a severe threat to environment and public health. Metal-organic frameworks (MOFs), as a very promising category of porous materials, have attracted more and more interest in research communities due to their extremely high surface areas, diverse nanostructures and unique properties. To meet the ever-increasing energy demand and tackle the heavy metal pollution in water, MOFs can function as ideal templates to prepare various …

Chronicle & Character, Taryn Moller Nicoll

LSU Master's Theses

In this thesis paper, I argue that the works in the exhibition 'Chronicle & Character' aim to demonstrate artistic citizenship and can contribute positively to society by provoking conversation about universally applicable (but often uncomfortable) topics. Experts such as David J. Elliot state that being an artistic citizen means that one’s concerns as an artist must shift from issues constrained to the artist alone to those of the artist’s surrounding community. The exhibition 'Chronicle & Character' contains works that serve as detailed chronicles of the medical or physiological experiences of my loved ones. This body of work presents how three …

The Effects Of Aerobic Exercise And Lipolytic Stimulation On Skeletal Muscle And Adipose Expression Of Perilipin 3 (Plin3) In Individuals With Type 2 Diabetes And Women With Polycystic Ovary Syndrome, Jeffrey Daniel Covington

LSU Doctoral Dissertations

Ectopic lipid accumulation in skeletal muscle is linked with insulin resistance and type 2 diabetes (T2D). Neutral lipid is stored as lipid droplets, which are coated by lipid droplet coat proteins. One important class of these proteins are the perilipins. Little research has focused on perilipin 3 (PLIN3) and coatomer gtp-ases, theorized to be involved in PLIN3 directed lipid oxidation. Under lipolytic stimulation with epinephrine or palmitate, forskolin, and ionomysin (PFI), primary human myotubes taken from health non-T2D donors showed increased protein content levels of PLIN3. Concordantly, following endurance exercise in non-T2D males—an experimental paradigm shown to increase lipolysis—levels of …

Thermoreversible And Injectable Abc Polypeptoid Hydrogels: Controlling The Hydrogel Properties Through Molecular Design, Sunting Xuan, Chang Uk Lee, Cong Chen, Andrew B. Doyle, Yueheng Zhang, Li Guo, Vijay T. John, Daniel Hayes, Donghui Zhang

Faculty Publications

© 2015 American Chemical Society. A series of ABC triblock copolypeptoids [i.e., poly(N-allyl glycine)-b-poly(N-methyl glycine)-b-poly(N-decyl glycine) (AMD)] with well-defined structure and varying composition have been synthesized by sequential primary amine-initiated ring-opening polymerization of the corresponding N-substituted N-carboxyanhydride monomers (Al-NCA, Me-NCA, and De-NCA). The ABC block copolypeptoids undergo sol-to-gel transitions with increasing temperature in water and biological media at low concentrations (2.5-10 wt %). The sol-gel transition is rapid and fully reversible with a narrow transition window, evidenced by the rheological measurements. The gelation temperature (Tgel) and mechanical stiffness of the hydrogels are highly tunable: Tgel in the 26.2-60.0 °C range, …

Synthesis, Characterization, And Evaluation Of Small Molecule-Based Fluorogenic Probes For The Detection Of Cellular Thiols, Rasika Ranatunga Nawimanage

LSU Doctoral Dissertations

Fluorescence methods for disease diagnosis and detection of important analytes are becoming popular route as a technique, as they offer a simple non-invasive approach. Recently, many novel fluorophores and probes have been reported for selectively and sensitively detecting low abundance biological species in disease pathways. Biological thiols, such as glutathione, cysteine, and homocysteine, along with the smallest member hydrogen sulfide, are key thiol analytes in biological environments, and they play a vital role in living systems by maintaining the redox homeostasis of cells. Alteration of their ratios can cause cellular dysfunction and cell death. Furthermore, thiol levels in cells and …

Space Radiation: The Number One Risk To Astronaut Health Beyond Low Earth Orbit, Jeffery C. Chancellor, Graham B.I. Scott, Jeffrey P. Sutton

Faculty Publications

Projecting a vision for space radiobiological research necessitates understanding the nature of the space radiation environment and how radiation risks influence mission planning, timelines and operational decisions. Exposure to space radiation increases the risks of astronauts developing cancer, experiencing central nervous system (CNS) decrements, exhibiting degenerative tissue effects or developing acute radiation syndrome. One or more of these deleterious health effects could develop during future multi-year space exploration missions beyond low Earth orbit (LEO). Shielding is an effective countermeasure against solar particle events (SPEs), but is ineffective in protecting crew members from the biological impacts of fast moving, highly-charged galactic …

A Study Of Biliverdin, Serum Albumin And Hemoglobin In The Scincid Lizard, Prasinohaema, Oliver Sinquefield

Honors Capstones

No abstract provided.

The Twin Taboos Of Discussing Religion And Politics : A Study Of Six "Basic" Emotions And Interpersonal Relationships In Response To Rick Perry's "Strong", Michael Francis Rold

LSU Doctoral Dissertations

A fear appeal has become a common way to describe a message created by individuals, groups, or entities to achieve an array of social and political goals. For instance, law firms may use fear-based advertisements on television by listing several debilitating diseases to educate potential clients about the side effects of certain drugs. In the realm of politics, candidates may use fear-based appeals in their messages as well: certain Republican candidates use the fear of attacks similar to the ones of September 11, 2001, to “scare” the American people into voting for the candidate who would best protect the country …