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Conning The Crypto Conman: End-To-End Analysis Of Cryptocurrency-Based Technical Support Scams, Bhupendra Acharya, Muhammad Saad, Antonio Emanuele Cinà, Lea Schönherr, Hoang Dai Nguyen, Adam Oest, Phani Vadrevu, Thorsten Holz Jan 2024

Conning The Crypto Conman: End-To-End Analysis Of Cryptocurrency-Based Technical Support Scams, Bhupendra Acharya, Muhammad Saad, Antonio Emanuele Cinà, Lea Schönherr, Hoang Dai Nguyen, Adam Oest, Phani Vadrevu, Thorsten Holz

Faculty Publications

The mainstream adoption of cryptocurrencies has led to a surge in wallet-related issues reported by ordinary users on social media platforms. In parallel, there is an increase in an emerging fraud trend called cryptocurrency-based technical support scam, in which fraudsters offer fake wallet recovery services and target users experiencing wallet-related issues.In this paper, we perform a comprehensive study of cryptocurrency-based technical support scams. We present an analysis apparatus called HoneyTweet to analyze this kind of scam. Through HoneyTweet, we lure over 9K scammers by posting 25K fake wallet support tweets (so-called honey tweets). We then deploy automated systems to interact …

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Mixed Method Study On Community College Instruction In Blended Social Science Courses, Andrea L. B. Eggenberger Dec 2023

Mixed Method Study On Community College Instruction In Blended Social Science Courses, Andrea L. B. Eggenberger

LSU Doctoral Dissertations

Community colleges have teaching faculty whose primary focus is educating their students and providing service to their institution. Community college teaching research has focused on innovation, students’ expectations, and the use of active learning techniques to foster student success. Research on blended courses has focused on instructional practices, learner engagement, and the benefits of blended learning for the community college student population. This study explores the relationship between student’s perceptions of the work in a blended developmental psychology course at two community colleges in Louisiana and their professors’ instructional decisions for their blended courses. The multiple-case study uses a convergent …

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Refining The Diagnosis Of Gestational Diabetes Mellitus: A Systematic Review And Meta-Analysis, Ellen C. Francis, Camille E. Powe, William L. Lowe, Sara L. White, Sara L. White, Denise M. Scholtens, Jiaxi Yang, Yeyi Zhu, Cuilin Zhang, Marie France Hivert, Marie France Hivert, Soo Heon Kwak, Arianne Sweeting, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram Dec 2023

Refining The Diagnosis Of Gestational Diabetes Mellitus: A Systematic Review And Meta-Analysis, Ellen C. Francis, Camille E. Powe, William L. Lowe, Sara L. White, Sara L. White, Denise M. Scholtens, Jiaxi Yang, Yeyi Zhu, Cuilin Zhang, Marie France Hivert, Marie France Hivert, Soo Heon Kwak, Arianne Sweeting, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram

Clinical Research Faculty Publications

Background: Perinatal outcomes vary for women with gestational diabetes mellitus (GDM). The precise factors beyond glycemic status that may refine GDM diagnosis remain unclear. We conducted a systematic review and meta-analysis of potential precision markers for GDM. Methods: Systematic literature searches were performed in PubMed and EMBASE from inception to March 2022 for studies comparing perinatal outcomes among women with GDM. We searched for precision markers in the following categories: maternal anthropometrics, clinical/sociocultural factors, non-glycemic biochemical markers, genetics/genomics or other -omics, and fetal biometry. We conducted post-hoc meta-analyses of a subset of studies with data on the association of maternal …

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Utility And Precision Evidence Of Technology In The Treatment Of Type 1 Diabetes: A Systematic Review, Laura M. Jacobsen, Jennifer L. Sherr, Elizabeth Considine, Angela Chen, Sarah M. Peeling, Margo Hulsmans, Sara Charleer, Marzhan Urazbayeva, Mustafa Tosur, Selma Alamarie, Maria J. Redondo, Korey K. Hood, Peter A. Gottlieb, Pieter Gillard, Jessie J. Wong, Irl B. Hirsch, Richard E. Pratley, Lori M. Laffel, Chantal Mathieu, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Robert K. Semple, Rebecca M. Reynolds, Leanne M. Redman, Rodica Pop-Busui, Toni I. Pollin, Wei Perng Dec 2023

Utility And Precision Evidence Of Technology In The Treatment Of Type 1 Diabetes: A Systematic Review, Laura M. Jacobsen, Jennifer L. Sherr, Elizabeth Considine, Angela Chen, Sarah M. Peeling, Margo Hulsmans, Sara Charleer, Marzhan Urazbayeva, Mustafa Tosur, Selma Alamarie, Maria J. Redondo, Korey K. Hood, Peter A. Gottlieb, Pieter Gillard, Jessie J. Wong, Irl B. Hirsch, Richard E. Pratley, Lori M. Laffel, Chantal Mathieu, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Robert K. Semple, Rebecca M. Reynolds, Leanne M. Redman, Rodica Pop-Busui, Toni I. Pollin, Wei Perng

Clinical Research Faculty Publications

Background: The greatest change in the treatment of people living with type 1 diabetes in the last decade has been the explosion of technology assisting in all aspects of diabetes therapy, from glucose monitoring to insulin delivery and decision making. As such, the aim of our systematic review was to assess the utility of these technologies as well as identify any precision medicine-directed findings to personalize care. Methods: Screening of 835 peer-reviewed articles was followed by systematic review of 70 of them (focusing on randomized trials and extension studies with ≥50 participants from the past 10 years). Results: We find …

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Personalized Feedback Intervention For Individuals With Low Distress Tolerance Who Smoke Cigarettes: A Randomized Controlled Trial Of A Digital Intervention, Brooke Y. Redmond, Aniqua Salwa, Jonathan B. Bricker, Julia D. Buckner, Lorra Garey, Michael J. Zvolensky Dec 2023

Personalized Feedback Intervention For Individuals With Low Distress Tolerance Who Smoke Cigarettes: A Randomized Controlled Trial Of A Digital Intervention, Brooke Y. Redmond, Aniqua Salwa, Jonathan B. Bricker, Julia D. Buckner, Lorra Garey, Michael J. Zvolensky

Faculty Publications

Introduction: Cigarette smoking remains the leading preventable cause of death and disability in the United States and frequently co-occurs with anxiety and depressive symptoms. A novel and integrative, theory-driven approach to address the heterogeneity of mood-related symptoms associated with cigarette use is to focus on transdiagnostic processes, such as distress tolerance, that underpin both mood-related symptoms and smoking behavior. The current study sought to develop and examine the feasibility, acceptability, and initial efficacy of a digitally delivered integrated personalized feedback intervention (PFI) that addresses smoking-distress tolerance relations. Methods: Participants included 121 adults (71.1 % male; Mage = 29.33 years, SD …

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Amazonian Mixed-Species Flocks Demonstrate Flexible Preferences For Vertical Forest Structure, Charles P.J. Coddington, W. Justin Cooper, Cameron L. Rutt, Karl Mokross, Bruna R. Amaral, Philip C. Stouffer, David A. Luther Dec 2023

Amazonian Mixed-Species Flocks Demonstrate Flexible Preferences For Vertical Forest Structure, Charles P.J. Coddington, W. Justin Cooper, Cameron L. Rutt, Karl Mokross, Bruna R. Amaral, Philip C. Stouffer, David A. Luther

Faculty Publications

How species interact with human-disturbed environments is a central focus of conservation biology. Within disturbed landscapes, regenerating forests have potential to provide habitat for forest species, especially as increasing amounts of primary forest are lost. As secondary forest regenerates beside primary forest, it increases habitat heterogeneity. However, relatively little is known about the influence of habitat heterogeneity on space use. In this study, we analyzed the topography and vertical vegetation structure of regenerating forest, small forest fragments, and undisturbed rainforest in the central Amazon to determine (1) how these structural characteristics influence understory mixed-species flock space use and (2) how …

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Leslie Paul Kozak, Phd (1940-2023), Eric Ravussin, Sven Enerback, Robert Koza Dec 2023

Leslie Paul Kozak, Phd (1940-2023), Eric Ravussin, Sven Enerback, Robert Koza

Clinical Research Faculty Publications

No abstract provided.

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An Aerobic Exercise Intervention To Improve Metabolic Health Among People Living With Hiv With At-Risk Alcohol Use: The Alive-Ex Research Study Protocol, Liz Simon, Stefany D. Primeaux, Danielle E. Levitt, Brianna Bourgeois, Neil M. Johannsen, Adrianna Peters, Jameel Ahmed, Richard H. Marshall, Alexandra H. Fairchild, Tekeda F. Ferguson, Patricia E. Molina Dec 2023

An Aerobic Exercise Intervention To Improve Metabolic Health Among People Living With Hiv With At-Risk Alcohol Use: The Alive-Ex Research Study Protocol, Liz Simon, Stefany D. Primeaux, Danielle E. Levitt, Brianna Bourgeois, Neil M. Johannsen, Adrianna Peters, Jameel Ahmed, Richard H. Marshall, Alexandra H. Fairchild, Tekeda F. Ferguson, Patricia E. Molina

Clinical Research Faculty Publications

Background: Effective antiretroviral therapy (ART) in people living with HIV (PLWH) has improved life expectancy and increased risk of age-associated cardiometabolic comorbidities. At-risk alcohol use is more frequent among PLWH and increases the risk of health challenges. PLWH with at-risk alcohol use are more likely to meet criteria for prediabetes/diabetes and this is associated with impaired whole-body glucose-insulin dynamics. Methods: The Alcohol & Metabolic Comorbidities in PLWH: Evidence Driven Interventions Study (ALIVE-Ex Study, NCT03299205) is a longitudinal, prospective, interventional study to determine the effects of an aerobic exercise protocol on improving dysglycemia among PLWH with at-risk alcohol use. The intervention …

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Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review, Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel Dec 2023

Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review, Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel

Clinical Research Faculty Publications

Background: Monogenic insulin resistance (IR) includes lipodystrophy and disorders of insulin signalling. We sought to assess the effects of interventions in monogenic IR, stratified by genetic aetiology. Methods: Systematic review using PubMed, MEDLINE and Embase (1 January 1987 to 23 June 2021). Studies reporting individual-level effects of pharmacologic and/or surgical interventions in monogenic IR were eligible. Individual data were extracted and duplicates were removed. Outcomes were analysed for each gene and intervention, and in aggregate for partial, generalised and all lipodystrophy. Results: 10 non-randomised experimental studies, 8 case series, and 23 case reports meet inclusion criteria, all rated as having …

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Participant Characteristics In The Prevention Of Gestational Diabetes As Evidence For Precision Medicine: A Systematic Review And Meta-Analysis, Siew Lim, Siew Lim, Wubet Worku Takele, Kimberly K. Vesco, Leanne M. Redman, Wesley Hannah, Wesley Hannah, Maxine P. Bonham, Mingling Chen, Sian C. Chivers, Andrea J. Fawcett, Andrea J. Fawcett, Jessica A. Grieger, Nahal Habibi, Gloria K.W. Leung, Kai Liu, Eskedar Getie Mekonnen, Maleesa Pathirana, Alejandra Quinteros, Rachael Taylor, Gebresilasea G. Ukke, Gebresilasea G. Ukke, Shao J. Zhou, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds Dec 2023

Participant Characteristics In The Prevention Of Gestational Diabetes As Evidence For Precision Medicine: A Systematic Review And Meta-Analysis, Siew Lim, Siew Lim, Wubet Worku Takele, Kimberly K. Vesco, Leanne M. Redman, Wesley Hannah, Wesley Hannah, Maxine P. Bonham, Mingling Chen, Sian C. Chivers, Andrea J. Fawcett, Andrea J. Fawcett, Jessica A. Grieger, Nahal Habibi, Gloria K.W. Leung, Kai Liu, Eskedar Getie Mekonnen, Maleesa Pathirana, Alejandra Quinteros, Rachael Taylor, Gebresilasea G. Ukke, Gebresilasea G. Ukke, Shao J. Zhou, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds

Clinical Research Faculty Publications

Background: Precision prevention involves using the unique characteristics of a particular group to determine their responses to preventive interventions. This study aimed to systematically evaluate the participant characteristics associated with responses to interventions in gestational diabetes mellitus (GDM) prevention. Methods: We searched MEDLINE, EMBASE, and Pubmed to identify lifestyle (diet, physical activity, or both), metformin, myoinositol/inositol and probiotics interventions of GDM prevention published up to May 24, 2022. Results: From 10347 studies, 116 studies (n = 40940 women) are included. Physical activity results in greater GDM reduction in participants with a normal body mass index (BMI) at baseline compared to …

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Precision Subclassification Of Type 2 Diabetes: A Systematic Review, Shivani Misra, Shivani Misra, Robert Wagner, Bige Ozkan, Martin Schön, Magdalena Sevilla-Gonzalez, Katsiaryna Prystupa, Caroline C. Wang, Raymond J. Kreienkamp, Sara J. Cromer, Mary R. Rooney, Daisy Duan, Anne Cathrine Baun Thuesen, Amelia S. Wallace, Aaron Leong, Aaron J. Deutsch, Mette K. Andersen, Liana K. Billings, Liana K. Billings, Robert H. Eckel, Wayne Huey Herng Sheu, Torben Hansen, Norbert Stefan, Mark O. Goodarzi, Debashree Ray, Elizabeth Selvin, Jose C. Florez, Paul W. Franks, Stephen S. Rich, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting Dec 2023

Precision Subclassification Of Type 2 Diabetes: A Systematic Review, Shivani Misra, Shivani Misra, Robert Wagner, Bige Ozkan, Martin Schön, Magdalena Sevilla-Gonzalez, Katsiaryna Prystupa, Caroline C. Wang, Raymond J. Kreienkamp, Sara J. Cromer, Mary R. Rooney, Daisy Duan, Anne Cathrine Baun Thuesen, Amelia S. Wallace, Aaron Leong, Aaron J. Deutsch, Mette K. Andersen, Liana K. Billings, Liana K. Billings, Robert H. Eckel, Wayne Huey Herng Sheu, Torben Hansen, Norbert Stefan, Mark O. Goodarzi, Debashree Ray, Elizabeth Selvin, Jose C. Florez, Paul W. Franks, Stephen S. Rich, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting

Clinical Research Faculty Publications

Background: Heterogeneity in type 2 diabetes presentation and progression suggests that precision medicine interventions could improve clinical outcomes. We undertook a systematic review to determine whether strategies to subclassify type 2 diabetes were associated with high quality evidence, reproducible results and improved outcomes for patients. Methods: We searched PubMed and Embase for publications that used ‘simple subclassification’ approaches using simple categorisation of clinical characteristics, or ‘complex subclassification’ approaches which used machine learning or ‘omics approaches in people with established type 2 diabetes. We excluded other diabetes subtypes and those predicting incident type 2 diabetes. We assessed quality, reproducibility and clinical …

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Precision Gestational Diabetes Treatment: A Systematic Review And Meta-Analyses, Jamie L. Benham, Véronique Gingras, Niamh Maire Mclennan, Jasper Most, Jennifer M. Yamamoto, Catherine E. Aiken, Susan E. Ozanne, Susan E. Ozanne, Rebecca M. Reynolds, Rebecca M. Reynolds, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs Dec 2023

Precision Gestational Diabetes Treatment: A Systematic Review And Meta-Analyses, Jamie L. Benham, Véronique Gingras, Niamh Maire Mclennan, Jasper Most, Jennifer M. Yamamoto, Catherine E. Aiken, Susan E. Ozanne, Susan E. Ozanne, Rebecca M. Reynolds, Rebecca M. Reynolds, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs

Clinical Research Faculty Publications

Background: Gestational Diabetes Mellitus (GDM) affects approximately 1 in 7 pregnancies globally. It is associated with short- and long-term risks for both mother and baby. Therefore, optimizing treatment to effectively treat the condition has wide-ranging beneficial effects. However, despite the known heterogeneity in GDM, treatment guidelines and approaches are generally standardized. We hypothesized that a precision medicine approach could be a tool for risk-stratification of women to streamline successful GDM management. With the relatively short timeframe available to treat GDM, commencing effective therapy earlier, with more rapid normalization of hyperglycaemia, could have benefits for both mother and fetus. Methods: We …

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Impact Of Individual And Environmental Factors On Dietary Or Lifestyle Interventions To Prevent Type 2 Diabetes Development: A Systematic Review, Dhanasekaran Bodhini, Robert W. Morton, Vanessa Santhakumar, Mariam Nakabuye, Hugo Pomares-Millan, Hugo Pomares-Millan, Christoffer Clemmensen, Stephanie L. Fitzpatrick, Marta Guasch-Ferre, James S. Pankow, Mathias Ried-Larsen, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy Dec 2023

Impact Of Individual And Environmental Factors On Dietary Or Lifestyle Interventions To Prevent Type 2 Diabetes Development: A Systematic Review, Dhanasekaran Bodhini, Robert W. Morton, Vanessa Santhakumar, Mariam Nakabuye, Hugo Pomares-Millan, Hugo Pomares-Millan, Christoffer Clemmensen, Stephanie L. Fitzpatrick, Marta Guasch-Ferre, James S. Pankow, Mathias Ried-Larsen, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy

Clinical Research Faculty Publications

Background: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular factors modify the efficacy of dietary or lifestyle interventions to prevent T2D. Methods: We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect …

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The Use Of Precision Diagnostics For Monogenic Diabetes: A Systematic Review And Expert Opinion, Rinki Murphy, Rinki Murphy, Kevin Colclough, Toni I. Pollin, Jennifer M. Ikle, Pernille Svalastoga, Kristin A. Maloney, Kristin A. Maloney, Cécile Saint-Martin, Janne Molnes, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Viswanathan Mohan, Shivani Misra, James B. Meigs Dec 2023

The Use Of Precision Diagnostics For Monogenic Diabetes: A Systematic Review And Expert Opinion, Rinki Murphy, Rinki Murphy, Kevin Colclough, Toni I. Pollin, Jennifer M. Ikle, Pernille Svalastoga, Kristin A. Maloney, Kristin A. Maloney, Cécile Saint-Martin, Janne Molnes, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Viswanathan Mohan, Shivani Misra, James B. Meigs

Clinical Research Faculty Publications

Background: Monogenic diabetes presents opportunities for precision medicine but is underdiagnosed. This review systematically assessed the evidence for (1) clinical criteria and (2) methods for genetic testing for monogenic diabetes, summarized resources for (3) considering a gene or (4) variant as causal for monogenic diabetes, provided expert recommendations for (5) reporting of results; and reviewed (6) next steps after monogenic diabetes diagnosis and (7) challenges in precision medicine field. Methods: Pubmed and Embase databases were searched (1990-2022) using inclusion/exclusion criteria for studies that sequenced one or more monogenic diabetes genes in at least 100 probands (Question 1), evaluated a non-obsolete …

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Treatment Effect Heterogeneity Following Type 2 Diabetes Treatment With Glp1-Receptor Agonists And Sglt2-Inhibitors: A Systematic Review, Katherine G. Young, Eram Haider Mcinnes, Robert J. Massey, Anna R. Kahkoska, Scott J. Pilla, Sridharan Raghavan, Maggie A. Stanislawski, Deirdre K. Tobias, Andrew P. Mcgovern, Andrew P. Mcgovern, Adem Y. Dawed, Angus G. Jones, Ewan R. Pearson, Ewan R. Pearson, John M. Dennis, John M. Dennis, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng Dec 2023

Treatment Effect Heterogeneity Following Type 2 Diabetes Treatment With Glp1-Receptor Agonists And Sglt2-Inhibitors: A Systematic Review, Katherine G. Young, Eram Haider Mcinnes, Robert J. Massey, Anna R. Kahkoska, Scott J. Pilla, Sridharan Raghavan, Maggie A. Stanislawski, Deirdre K. Tobias, Andrew P. Mcgovern, Andrew P. Mcgovern, Adem Y. Dawed, Angus G. Jones, Ewan R. Pearson, Ewan R. Pearson, John M. Dennis, John M. Dennis, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng

Clinical Research Faculty Publications

Background: A precision medicine approach in type 2 diabetes requires the identification of clinical and biological features that are reproducibly associated with differences in clinical outcomes with specific anti-hyperglycaemic therapies. Robust evidence of such treatment effect heterogeneity could support more individualized clinical decisions on optimal type 2 diabetes therapy. Methods: We performed a pre-registered systematic review of meta-analysis studies, randomized control trials, and observational studies evaluating clinical and biological features associated with heterogenous treatment effects for SGLT2-inhibitor and GLP1-receptor agonist therapies, considering glycaemic, cardiovascular, and renal outcomes. After screening 5,686 studies, we included 101 studies of SGLT2-inhibitors and 75 studies …

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Disease-Modifying Therapies And Features Linked To Treatment Response In Type 1 Diabetes Prevention: A Systematic Review, Jamie L. Felton, Kurt J. Griffin, Kurt J. Griffin, Richard A. Oram, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Stephen S. Rich, Gabriela S.F. Monaco, Carmella Evans-Molina, Linda A. Dimeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M. Wentworth, Maria J. Redondo, Emily K. Sims, Emily K. Sims, Paul W. Franks, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Leanne M. Redman Dec 2023

Disease-Modifying Therapies And Features Linked To Treatment Response In Type 1 Diabetes Prevention: A Systematic Review, Jamie L. Felton, Kurt J. Griffin, Kurt J. Griffin, Richard A. Oram, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Stephen S. Rich, Gabriela S.F. Monaco, Carmella Evans-Molina, Linda A. Dimeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M. Wentworth, Maria J. Redondo, Emily K. Sims, Emily K. Sims, Paul W. Franks, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Leanne M. Redman

Clinical Research Faculty Publications

Background: Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneity in disease progression and therapy response has limited translation to clinical practice, highlighting the need for precision medicine approaches to T1D disease modification. Methods: To understand the state of knowledge in this area, we performed a systematic review of randomized-controlled trials with ≥50 participants cataloged in PubMed or Embase from the past 25 years testing T1D disease-modifying therapies and/or identifying features linked to treatment response, analyzing bias using a …

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Prognostic Relevance Of Gait-Related Cognitive Functions For Dementia Conversion In Amnestic Mild Cognitive Impairment, Cosimo Tuena, Sara Maestri, Silvia Serino, Elisa Pedroli, Marco Stramba-Badiale, Giuseppe Riva, Lisa C. Silbert, Betty Lind, Rachel Crissey, Jeffrey A. Kaye, Raina Carter, Sara Dolen, Joseph Quinn, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James Brewer, Adam Fleisher, Helen Vanderswag, Jaimie Ziolkowski, Judith L. Heidebrink, Lisa Zbizek-Nulph, Joanne L. Lord, Colleen S. Albers, Ronald Petersen, Sara S. Mason, David Knopman, Kris Johnson, Javier Villanueva-Meyer, Valory Pavlik, Nathaniel Pacini Dec 2023

Prognostic Relevance Of Gait-Related Cognitive Functions For Dementia Conversion In Amnestic Mild Cognitive Impairment, Cosimo Tuena, Sara Maestri, Silvia Serino, Elisa Pedroli, Marco Stramba-Badiale, Giuseppe Riva, Lisa C. Silbert, Betty Lind, Rachel Crissey, Jeffrey A. Kaye, Raina Carter, Sara Dolen, Joseph Quinn, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James Brewer, Adam Fleisher, Helen Vanderswag, Jaimie Ziolkowski, Judith L. Heidebrink, Lisa Zbizek-Nulph, Joanne L. Lord, Colleen S. Albers, Ronald Petersen, Sara S. Mason, David Knopman, Kris Johnson, Javier Villanueva-Meyer, Valory Pavlik, Nathaniel Pacini

Clinical Research Faculty Publications

Background: Increasing research suggests that gait abnormalities can be a risk factor for Alzheimer’s Disease (AD). Notably, there is growing evidence highlighting this risk factor in individuals with amnestic Mild Cognitive Impairment (aMCI), however further studies are needed. The aim of this study is to analyze cognitive tests results and brain-related measures over time in aMCI and examine how the presence of gait abnormalities (neurological or orthopedic) or normal gait affects these trends. Additionally, we sought to assess the significance of gait and gait-related measures as prognostic indicators for the progression from aMCI to AD dementia, comparing those who converted …

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Global Dataset Of Soil Organic Carbon In Tidal Marshes, Tania L. Maxwell, André S. Rovai, Maria Fernanda Adame, Janine B. Adams, José Álvarez-Rogel, William E.N. Austin, Kim Beasy, Francesco Boscutti, Michael E. Böttcher, Tjeerd J. Bouma, Richard H. Bulmer, Annette Burden, Shannon A. Burke, Saritta Camacho, Doongar R. Chaudhary, Gail L. Chmura, Margareth Copertino, Grace M. Cott, Christopher Craft, John Day, Carmen B. De Los Santos, Lionel Denis, Weixin Ding, Joanna C. Ellison, Carolyn J. Ewers Lewis, Luise Giani, Maria Gispert, Swanne Gontharet, José A. González-Pérez, M. Nazaret González-Alcaraz, Connor Gorham, Anna Elizabeth L. Graversen, Anthony Grey Dec 2023

Global Dataset Of Soil Organic Carbon In Tidal Marshes, Tania L. Maxwell, André S. Rovai, Maria Fernanda Adame, Janine B. Adams, José Álvarez-Rogel, William E.N. Austin, Kim Beasy, Francesco Boscutti, Michael E. Böttcher, Tjeerd J. Bouma, Richard H. Bulmer, Annette Burden, Shannon A. Burke, Saritta Camacho, Doongar R. Chaudhary, Gail L. Chmura, Margareth Copertino, Grace M. Cott, Christopher Craft, John Day, Carmen B. De Los Santos, Lionel Denis, Weixin Ding, Joanna C. Ellison, Carolyn J. Ewers Lewis, Luise Giani, Maria Gispert, Swanne Gontharet, José A. González-Pérez, M. Nazaret González-Alcaraz, Connor Gorham, Anna Elizabeth L. Graversen, Anthony Grey

Faculty Publications

Tidal marshes store large amounts of organic carbon in their soils. Field data quantifying soil organic carbon (SOC) stocks provide an important resource for researchers, natural resource managers, and policy-makers working towards the protection, restoration, and valuation of these ecosystems. We collated a global dataset of tidal marsh soil organic carbon (MarSOC) from 99 studies that includes location, soil depth, site name, dry bulk density, SOC, and/or soil organic matter (SOM). The MarSOC dataset includes 17,454 data points from 2,329 unique locations, and 29 countries. We generated a general transfer function for the conversion of SOM to SOC. Using this …

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The Longitudinal Associations Of Body Dissatisfaction With Health And Wellness Behaviors In Midlife And Older Women, Lisa Smith Kilpela, Savannah C. Hooper, Casey L. Straud, Victoria B. Marshall, Christina L. Verzijl, Tiffany M. Stewart, Taylur T. Loera, Carolyn Black Becker Dec 2023

The Longitudinal Associations Of Body Dissatisfaction With Health And Wellness Behaviors In Midlife And Older Women, Lisa Smith Kilpela, Savannah C. Hooper, Casey L. Straud, Victoria B. Marshall, Christina L. Verzijl, Tiffany M. Stewart, Taylur T. Loera, Carolyn Black Becker

Population and Public Health Science Faculty Publications

Emerging research suggests that body dissatisfaction (BD) is prevalent among midlife and older women (i.e., upwards of 70%). Cross-sectionally, BD is associated with myriad poor health and wellness outcomes (e.g., depression, disordered eating, bad nutrition) in midlife/older women. However, relatively few studies have examined the longitudinal relations between BD and health outcomes in this population. This preliminary study investigated the longitudinal associations of BD with wellbeing and health-related quality of life (QOL) among midlife/older adult women over one year. Participants (n = 86, women aged 40–72 years, M = 51.49, SD = 7.34, 86% white) completed self-report measures of BD, …

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Mid-Miocene Sea Level Altitude Of The Qaidam Basin, Northern Tibetan Plateau, Yuanyuan Sun, Yu Liang, Hu Liu, Jun Liu, Junliang Ji, Xue Ke, Xiaobo Liu, Yuxin He, Huanye Wang, Bin Zhang, Yongsu Zhang, Guangsheng Zhuang, Junling Pei, Yongxiang Li, Cheng Quan, Jianxing Li, Jonathan C. Aitchison, Weiguo Liu, Zhonghui Liu Dec 2023

Mid-Miocene Sea Level Altitude Of The Qaidam Basin, Northern Tibetan Plateau, Yuanyuan Sun, Yu Liang, Hu Liu, Jun Liu, Junliang Ji, Xue Ke, Xiaobo Liu, Yuxin He, Huanye Wang, Bin Zhang, Yongsu Zhang, Guangsheng Zhuang, Junling Pei, Yongxiang Li, Cheng Quan, Jianxing Li, Jonathan C. Aitchison, Weiguo Liu, Zhonghui Liu

Faculty Publications

A detailed uplift history of the Tibetan Plateau is essential for disentangling the proposed geodynamical models and assessing its impacts on climate and biodiversity. However, when and how the plateau formed remains highly controversial. Here, we present unusual geochemical indicators of marine signatures in the Cenozoic terrestrial strata of the Qaidam Basin, northern Tibetan Plateau, with strong implications for the basin altitude. Our investigations across the basin reveal typical marine alkenones and anomalously high carbonate carbon isotopic values during the mid-Miocene, but not at earlier stages, which are accompanied by a divergent trend in the paired carbonate oxygen and leaf …

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Multiscale Analysis Of Spatial Accessibility To Acute Hospitals In Carinthia, Austria, Changzhen Wang, Michael Leitner, Gernot Paulus Dec 2023

Multiscale Analysis Of Spatial Accessibility To Acute Hospitals In Carinthia, Austria, Changzhen Wang, Michael Leitner, Gernot Paulus

Faculty Publications

Health care accessibility studies are well established in the US but lacking in Austria, even though both experience high costs and have hospital care as the largest contributor to health care spending. This study aims to examine multiscale spatial accessibility to acute hospitals in Carinthia, Austria. Using the most recent data at census block and 250 meter grid levels, we refine proximity and generalized two-step floating catchment area (G2SFCA) methods while accounting for the modifiable areal unit problem (MAUP) and edge effects. For census blocks and 250 meter grids, the mean travel times to the nearest acute hospitals are 16 …

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Digital Archives: How Western Newspapers Frame Our Remembrance Of The Gezi Park Protest, Nihar Sreepada, Ahmet Aksoy Dec 2023

Digital Archives: How Western Newspapers Frame Our Remembrance Of The Gezi Park Protest, Nihar Sreepada, Ahmet Aksoy

Faculty Publications

We analyze the coverage of the Gezi Park protests by two major Western newspapers - The New York Times and The Guardian - through the lens of media framing, rhetoric, and collective memory. We argue that these digital archives frame Turkey's Gezi Park protests as a challenge to an authoritarian government by promoting the themes of unrest as a conflict of ideologies, oppression of citizens, and the park as a site of memory. In a concluding section, we focus on the significance of digital archives as repositories of collective memory and the role of media framing in shaping these reconstructions …

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Do Contributing Files Provide Information About Oss Newcomers' Onboarding Barriers?, Felipe Fronchetti, David C. Shepherd, Igor Wiese, Christoph Treude, Marco Aurélio Gerosa, Igor Steinmacher Nov 2023

Do Contributing Files Provide Information About Oss Newcomers' Onboarding Barriers?, Felipe Fronchetti, David C. Shepherd, Igor Wiese, Christoph Treude, Marco Aurélio Gerosa, Igor Steinmacher

Faculty Publications

Effectively onboarding newcomers is essential for the success of open source projects. These projects often provide onboarding guidelines in their 'CONTRIBUTING' files (e.g., CONTRIBUTING.md on GitHub). These files explain, for example, how to find open tasks, implement solutions, and submit code for review. However, these files often do not follow a standard structure, can be too large, and miss barriers commonly found by newcomers. In this paper, we propose an automated approach to parse these CONTRIBUTING files and assess how they address onboarding barriers. We manually classified a sample of files according to a model of onboarding barriers from the …

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From Empowerment Movement To Hijacked Hashtag: A Thematic Analysis Of #Shoutyourabortion, Sidney R. Reynen Nov 2023

From Empowerment Movement To Hijacked Hashtag: A Thematic Analysis Of #Shoutyourabortion, Sidney R. Reynen

LSU Master's Theses

This study delves into the digital landscape of the contentious abortion debate, focusing on the use and hijacking of the Shout Your Abortion hashtag. Drawing parallels to previous research on digital feminism, hashtag activism, and hashtag hijacking, this study further expands such literature by revealing shifts in anti-abortion rhetoric and strategies post-Dobbs. I identified seven themes within the supportive discourse: abortion narratives, pro-choice and other feminist rhetoric, calls to action, feminist art and shareables, reproductive health information and resources, positive-to-neutral mentions of the movement, and engagements with anti-abortion users. Within the hijacked posts, I identified five themes: Shout …

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A Dance Of Resistance: The Puerto Rican Bomba As A Means To Challenge Intersections Of Discrimination On The Island, Daniel Loving Nov 2023

A Dance Of Resistance: The Puerto Rican Bomba As A Means To Challenge Intersections Of Discrimination On The Island, Daniel Loving

LSU Master's Theses

This thesis examines the Puerto Rican Bomba as a multifaceted cultural and political phenomenon, focusing on its pivotal role in challenging and subverting the enduring issues of racial and gender discrimination on the Island. Drawing from an interdisciplinary framework that encompasses cultural studies, anthropology, history, performance and film studies, this research elucidates the complex interplay between Bomba's rhythmic and choreographic elements, its historical evolution, and its contemporary significance in the context of Puerto Rico's sociopolitical landscape. By analyzing Bomba's historical roots in African and indigenous traditions, its adaptation during colonial and post-colonial eras, and its ongoing relevance in the struggle …

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On Virtue Ethics Theory And Elementary Music Education, Joshua Burgos Nov 2023

On Virtue Ethics Theory And Elementary Music Education, Joshua Burgos

LSU Doctoral Dissertations

This dissertation uses virtue ethics theory, teacher research method, and self-study to examine how I perceive myself as contributing to cultivating virtuous persons. Virtue ethics theory, teacher research method, and self-study are empirical, using concrete methods of data generation and analysis, and conceptual, relating to studying philosophical research, ideas, and interpretations (Annas, 2007; Check & Schutt, 2012; Kemmis & McTaggart, 1988). The study aimed to discover how virtue is cultivated through music education and improve teaching practice using virtue ethics theory and empirical research to offer insight into how virtue is cultivated. The study was conducted in an elementary school …

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Bariatric Surgery Alters Mitochondrial Function In Gut Mucosa, Robert C. Ross, Elizabeth C. Heintz, Elizabeth R.M. Zunica, R. Leigh Townsend, Amanda E. Spence, Philip R. Schauer, John P. Kirwan, Christopher L. Axelrod, Vance L. Albaugh Nov 2023

Bariatric Surgery Alters Mitochondrial Function In Gut Mucosa, Robert C. Ross, Elizabeth C. Heintz, Elizabeth R.M. Zunica, R. Leigh Townsend, Amanda E. Spence, Philip R. Schauer, John P. Kirwan, Christopher L. Axelrod, Vance L. Albaugh

Division of Basic Science Faculty Publications

Background: The obesity pandemic has worsened global disease burden, including type 2 diabetes, cardiovascular disease, and cancer. Metabolic/bariatric surgery (MBS) is the most effective and durable obesity treatment, but the mechanisms underlying its long-term weight loss efficacy remain unclear. MBS drives substrate oxidation that has been linked to improvements in metabolic function and improved glycemic control that are potentially mediated by mitochondria—a primary site of energy production. As such, augmentation of intestinal mitochondrial function may drive processes underlying the systemic metabolic benefits of MBS. Herein, we applied a highly sensitive technique to evaluate intestinal mitochondrial function ex vivo in a …

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Effectiveness Of Static Versus Dynamic Language Assessments, Lauren Betzer Nov 2023

Effectiveness Of Static Versus Dynamic Language Assessments, Lauren Betzer

Honors Capstones

No abstract provided.

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A Descriptive Study Of Louisiana 4-H 8th Through 12th Graders' Perceptions Of Career And College Readiness, Carrie M. Lane Nov 2023

A Descriptive Study Of Louisiana 4-H 8th Through 12th Graders' Perceptions Of Career And College Readiness, Carrie M. Lane

LSU Master's Theses

As youth leave primary education and enter college or a career path, preparing those youth to ensure success has fallen, in large part, upon formal and non-formal youth educators. Encouraging students to apply and complete college has been a focus of education professionals for many years. Historically, gauging college and career readiness (CCR), academic institutions have relied on academic performance in areas of English Language Arts and Mathematics (Mattern, et. al, 2014). The use of academic focused measures instead of student-based evaluation had its drawbacks. While core education is important, measuring soft skills needed for the workforce and college environment …

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Nikolai Medtner And The Beethoven Tradition In Performance And Pedagogy, Jamie E. Gurt Oct 2023

Nikolai Medtner And The Beethoven Tradition In Performance And Pedagogy, Jamie E. Gurt

LSU Doctoral Dissertations

The compositions of Nikolai Medtner (1880-1951) have received increasing attention in both performance and scholarship. This monograph explores the influence of the Beethoven tradition in Medtner’s piano sonatas with a focus on performance and pedagogy. An examination of Medtner’s biography contextualizes Medtner’s training in composition and performance, as well as philosophical and personal influences. Next, the study examines Medtner’s writings on Beethoven as well as current scholarship on the piano sonatas of the two composers, observing influences in overall formal and stylistic characteristics. Exploring performance and pedagogy, the study considers examples from Medtner’s recordings of his Sonata Tragica, Op. …

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