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Do Major Customers Affect Firms' Environmental, Social And Governance Activities?, Feng Dong, John A. Doukas, Stephanie Walton, Rongyao Gloria Zhang, Yiyang Zhang Jan 2025

Do Major Customers Affect Firms' Environmental, Social And Governance Activities?, Feng Dong, John A. Doukas, Stephanie Walton, Rongyao Gloria Zhang, Yiyang Zhang

Faculty Publications

We examine the role of major customers in shaping firms' environmental, social and governance (ESG) practices. We find that firms with major customer relationships undertake fewer ESG activities compared to those without such ties. The association is attenuated when institutional ownership is high, firms are less diversified, customers exhibit greater bankruptcy risk and lower switching costs and during periods of elevated equity market sentiment. Taken together, our findings highlight that reliance on a concentrated customer base can weaken firms’ incentives to engage in ESG practices, with important implications for supply chain sustainability.


Rethinking The Lake History Of Taylor Valley, Antarctica During The Ross Sea I Glaciation, Michael S. Stone, Peter T. Doran, Krista F. Myers Jan 2025

Rethinking The Lake History Of Taylor Valley, Antarctica During The Ross Sea I Glaciation, Michael S. Stone, Peter T. Doran, Krista F. Myers

Faculty Publications

The Ross Sea I glaciation, marked by the northward advance of the Ross Ice Sheet (RIS) in the Ross Sea, east Antarctica, corresponds with the last major expansion of the West Antarctic Ice Sheet during the last glacial period. During its advance, the RIS was grounded along the southern Victoria Land coast, completely blocking the mouths of several of the McMurdo Dry Valleys (MDVs). Several authors have proposed that very large paleolakes, proglacial to the RIS, existed in many of the MDVs. Studies of these large paleolakes have been key in the interpretation of the regional landscape, climate, hydrology, and …


The Work Of An Hour: A Case Study Of Propaganda, Michael F. Russo Jan 2025

The Work Of An Hour: A Case Study Of Propaganda, Michael F. Russo

Faculty Publications

This research paper discusses the messaging of United States President George W. Bush and his administration regarding the U.S. led invasion of Iraq. Transcripts of presidential communications, national news programs, and public opinion polls from 2001-03 were analyzed to identify patterns in these communications. This review demonstrated techniques similar to those used in historical propaganda campaigns to sway public opinion. The introduction and repetition of key terminology from the government was followed by magnification by television news programs. These messages were broadcast despite lack of evidence of Iraq’s involvement with the 9/11 attacks or their possession of weapons of mass …


Impact Report, 2024-2025, Lsu Libraries Jan 2025

Impact Report, 2024-2025, Lsu Libraries

Libraries Impact Reports

No abstract provided.


Reservoir Engineering For Co₂ Storage: Fundamental & Practical Aspects, Mehdi Zeidouni Jan 2025

Reservoir Engineering For Co₂ Storage: Fundamental & Practical Aspects, Mehdi Zeidouni

LSU Faculty-Published Books

Bridging the gap between carbon storage theory and petroleum engineering practice.

This comprehensive guide distills nearly two decades of research and teaching into a clear, application-focused resource on geological CO2 storage modeling, carbon capture and storage modeling (CCS modeling), and CO2 reservoir modeling—all tailored specifically for petroleum engineers.

While GCS modeling has historically been driven by physics, mathematics, and hydrogeology, petroleum engineering CO2 modeling often requires a different approach. This book translates complex, multidisciplinary CO2 geological modeling techniques into a unified, petroleum engineer–friendly framework. Whether your focus is CO2 sequestration engineering, enhanced oil recovery CO2 modeling, or transitioning from oil …


All-Electron Molecular Tunnel Ionization Based On The Weak-Field Asymptotic Theory In The Integral Representation, Imam S. Wahyutama, Denawakage D. Jayasinghe, François Mauger, Kenneth Lopata, Kenneth J. Schafer Jan 2025

All-Electron Molecular Tunnel Ionization Based On The Weak-Field Asymptotic Theory In The Integral Representation, Imam S. Wahyutama, Denawakage D. Jayasinghe, François Mauger, Kenneth Lopata, Kenneth J. Schafer

Faculty Publications

Tunnel ionization (TI) underlies many important ultrafast processes, such as high-harmonic generation and strong-field ionization. Among the existing theories for TI, many-electron weak-field asymptotic theory (ME-WFAT) is by design capable of accurately treating many-electron effects in TI. An earlier version of ME-WFAT relied on an accurate representation of the asymptotic tail of the orbitals, which hindered its implementation in Gaussian-basis-set-based quantum chemistry programs. In this work, we reformulate ME-WFAT in the integral representation, which makes the quality of the asymptotic tail much less critical, hence greatly facilitating its implementation in standard quantum chemistry packages. The integral reformulation introduced here is …


Lsu General Catalog 2025-2026, Louisiana State University And Agricultural And Mechanical College Jan 2025

Lsu General Catalog 2025-2026, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The LSU General Catalog includes information on registration and financial aid as well as academic services offered to all students.


Hope For Louisiana’S Coast: From Catastrophic Loss To Transient Gain, Richard Condrey, Brian D. Marx, Frank Saforo, Rudy Bartels Jan 2025

Hope For Louisiana’S Coast: From Catastrophic Loss To Transient Gain, Richard Condrey, Brian D. Marx, Frank Saforo, Rudy Bartels

Faculty Publications

Louisiana’s fifty-billion-dollar coastal restoration plan relies on selected interpretations of a small dataset of coastwide land measurements. In the 1990’s, the plan’s founders used a mathematically impossible interpretation of an improbable manipulation of the initial (1932-1990) dataset to justify their misconceptions regarding natural conditions; delta-switching; and a failing, 60-year restoration goal. In 2017, the dataset was updated to 2016 and used to suggest that land loss had slowed to -28 km2/yr (-1 football field/100 min) since 2010. We find that the dataset does not support this suggestion. Rather, we find the dataset supports our hypothesis that increasing precipitation in the …


Mapping Glams: Creating A National Dataset Of Glams To Develop A Categorical Climate-Change Risk Assessment Scale, Edward Benoitiii, Jill Trepanier, Jennifer Vanos, Emily Fisher, Kaitlyn Bailey, Annie Waddell, Haley Moore, Mandy Hatman, Mary Sidwell, Symonne Russell, Virginia Seger, Paige Boutte, Amanda Latta, Zoe Mohammad, Kyriel Felton, Erin Deliman, Breanna Benson-Pearce, Wendy Johnson, Allyson Russell, Baillie Pretzer, Christopher Reeder, Melissa Mcconnell, Lisa Dahlke, Kaitlynn Melear, Lillian Bodi, Savannah T. Lyle, Zach Lannes, Gwen L. Wells, Benjamin A. Teincuff, Jason M. Straight, Tiffany Rockwell, Shane T. Manthei, Jennifer L. Benner Jan 2025

Mapping Glams: Creating A National Dataset Of Glams To Develop A Categorical Climate-Change Risk Assessment Scale, Edward Benoitiii, Jill Trepanier, Jennifer Vanos, Emily Fisher, Kaitlyn Bailey, Annie Waddell, Haley Moore, Mandy Hatman, Mary Sidwell, Symonne Russell, Virginia Seger, Paige Boutte, Amanda Latta, Zoe Mohammad, Kyriel Felton, Erin Deliman, Breanna Benson-Pearce, Wendy Johnson, Allyson Russell, Baillie Pretzer, Christopher Reeder, Melissa Mcconnell, Lisa Dahlke, Kaitlynn Melear, Lillian Bodi, Savannah T. Lyle, Zach Lannes, Gwen L. Wells, Benjamin A. Teincuff, Jason M. Straight, Tiffany Rockwell, Shane T. Manthei, Jennifer L. Benner

Faculty Publications

Introduction. The PROTECCT-GLAM project aims to assess and address climate risks for U.S. galleries, libraries, archives, and museums (GLAMs). The project team began with creating a national dataset of GLAMs. Method. The project team used existing datasets that required different auditing and manipulation techniques to align its data. Following the data normalization, the master file included 77,960 entries. Analysis and Results. The project team used ArcGIS Pro to analyze a dataset of galleries, libraries, archives, and museums (GLAMs) for risk from sea level rise, finding 16,877 GLAMs within 30 kilometres of the U.S. coast, with California, New York, Maryland, Florida, …


Vertebrate Fossils Of Louisiana, Suyin Ting, Lorene E. Smith, Connor D. White, Irene Martí Gil Jan 2025

Vertebrate Fossils Of Louisiana, Suyin Ting, Lorene E. Smith, Connor D. White, Irene Martí Gil

Special Publications of the Museum of Natural Science

No abstract provided.


An Early Web History Of Vaccine Skeptical Digital Rhetorics, Miles C. Coleman, Will Mari Jan 2025

An Early Web History Of Vaccine Skeptical Digital Rhetorics, Miles C. Coleman, Will Mari

Faculty Publications

Vaccine hesitancy is a public health threat stoked by vaccine skeptical rhetorics that circulate via the Web. While there is a body of work that studies the digital rhetorical tactics of vaccine skeptics, most of this work focuses on the Web rhetorics of the “Web 2.0” era, leaving the “Web 1.0” era relatively understudied and, in turn, foreclosing opportunities to look back before moving forward in the current moment. In efforts to yield glimpses into the antecedents of digital culture that have shaped contemporary vaccine skeptical discourses, in this article, we draw on systematically sourced website “snapshots” of vaccine skeptical …


Improved Performance Of Catalysts Containing Pt, Pt-Sn, And V In The Dehydrogenation Of N-Butane By Radio-Frequency Induction Heating, Cameron L. Roman, Jonathan Lucas, James A. Dorman, Kerry M. Dooley Jan 2025

Improved Performance Of Catalysts Containing Pt, Pt-Sn, And V In The Dehydrogenation Of N-Butane By Radio-Frequency Induction Heating, Cameron L. Roman, Jonathan Lucas, James A. Dorman, Kerry M. Dooley

Faculty Publications

Due to an abundance of shale gas, manufacturers are interested in meeting increased demands for alkenes, especially n-alkenes, by the dehydrogenation of light alkanes. While the catalysts for these reactions have been studied for many years, alkene selectivity and deactivation remain challenging problems. This work addresses these problems by the substitution of a localized indirect heating method (radio-frequency induction heating, RF-IH) for more traditional process heating employing steam or burners (e.g., natural gas combustion). RF-IH has been applied to the dehydrogenation of n-butane to C4 alkenes by utilizing magnetically susceptible catalysts based on Fe/Fe3O4 susceptors. Magnetic core-shell catalysts with either …


Poromechanical Solution For One-Dimensional Large Strain Consolidation Of Modified Cam-Clay Soil, Sheng Li Chen, Hai Sui Yu, Younane N. Abousleiman, Christopher E. Kees Jan 2025

Poromechanical Solution For One-Dimensional Large Strain Consolidation Of Modified Cam-Clay Soil, Sheng Li Chen, Hai Sui Yu, Younane N. Abousleiman, Christopher E. Kees

Faculty Publications

A theoretical model describing the one-dimensional large strain consolidation of the modified Cam-Clay soil is presented in this paper. The model is based on the Lagrangian formulation and is capable of featuring the variability of soil compressibility (inherently due to the direct incorporation of the specific Cam-Clay plasticity model) and permeability, as well as the impact of the overconsolidation ratio (OCR). The derivation starts from the establishment of the incremental stress–strain relations for both purely elastic and elastoplastic deformations under one-dimensional compression conditions, and thereafter the coefficients of compressibility/volume change that are essential to the consolidation analysis. The governing partial …


Clocking In And Speaking Out: Navigating Workday Rhythms For Voice Behaviors, Katelyn M. Reeves Dec 2024

Clocking In And Speaking Out: Navigating Workday Rhythms For Voice Behaviors, Katelyn M. Reeves

LSU Master's Theses

Employee voice behaviors help organizations identify problems, increase productivity, and enhance satisfaction. Most literature focuses on daily-level variations while neglecting potential within-day variations that may have a stronger impact on voice engagement. To investigate within-day variations, this thesis applies chronotype synchrony to explain resource depletion throughout the day, which will determine voice engagement. An experience sampling study with the day reconstruction method of 250 employees revealed that having a morning chronotype leads to a more promotive and prohibitive voice in the morning, with a decline throughout the day due to resource depletion increasing throughout the day. Further, individuals with evening …


Co2 In Flowing Freshwaters: Macro Scale Database Compilation, Addressing Ph Bias In Co2 Estimates, And Quantifying Cross-Scale Interactions, Timothy R. Toavs Dec 2024

Co2 In Flowing Freshwaters: Macro Scale Database Compilation, Addressing Ph Bias In Co2 Estimates, And Quantifying Cross-Scale Interactions, Timothy R. Toavs

LSU Doctoral Dissertations

This dissertation focuses on carbon dioxide (CO2) dynamics in flowing freshwaters, contributing to the growing body of knowledge about inland water carbon cycles. The research is structured into three main chapters, each progressing towards the objective of utilizing variability in flowing freshwaters to further understand carbon dynamics, anthropogenic land cover impacts, and potential impacts from a changing climate. Chapter one compiles a 30-year dataset of pCO2 measurements from flowing freshwater systems across the contiguous United States. This dataset, referred to as CDFLOW, includes over 750,000 pCO2 estimates from more than 35,000 locations. It serves …


Nipping Crime In The Bud: The Spatial Relationship Between Crime And Meeting People’S Needs, Alicia Cerquone Dec 2024

Nipping Crime In The Bud: The Spatial Relationship Between Crime And Meeting People’S Needs, Alicia Cerquone

LSU Master's Theses

The recent high-profile killings of people by the police brought attention to police violence, and prompted activists to call for an end to police violence. Drawing from an understanding of strain theory (Merton, 1938; Farnworth & Leiber, 1989; Agnew, 1992; Agnew, 2001; Agnew, 2008) and Tucker and Cadora’s (2003) ideas of justice reinvestment, this research was designed with the belief that police funding can be better used to help people meet their basic needs of housing, healthcare, and education. This research is concerned with the spatial relationship between crime and the quality of social infrastructure, or the programs in place …


Analyzing Errors Across Nonword Repetition Tasks For Clinical Utility Among Children Who Speak African American English, Tatum Carver-Dews Dec 2024

Analyzing Errors Across Nonword Repetition Tasks For Clinical Utility Among Children Who Speak African American English, Tatum Carver-Dews

LSU Master's Theses

Purpose

Within the context of African American English (AAE), this study aimed to examine the clinical utility of three different types of NWR tasks to differentiate children with Developmental Language Disorder (DLD) from those who are typically developing (TD), by percentage of phonemes correct (PPC) and by type of error (e.g., consonants or vowels; omissions or substitutions). Additionally, this study allowed for examination of the relationship between the children’s NWR performance and their density of dialect-specific forms.

Methods

The data came from 50 kindergarteners (25 females, 25 males) who had participated in a multi-year study of childhood DLD within the …


Nanofabrication Of Tetraphenyl Porphyrin Surface Assemblies Linked With Tin Tetrachloride: A Scanning Probe Microscopy Investigation, Quynh Do Dec 2024

Nanofabrication Of Tetraphenyl Porphyrin Surface Assemblies Linked With Tin Tetrachloride: A Scanning Probe Microscopy Investigation, Quynh Do

LSU Doctoral Dissertations

Scanning probe microscopy (SPM) and colloidal lithography methods were used to study the covalent coupling of porphyrins to surfaces. In this dissertation, experimental methods for SPM operation, techniques, and applications are described. Measurement of tip-sample interactions between a sharp tip and surface is translated into digital image data maps with x-, y-, and z-data. Colloidal lithography can be used to fabricate test platforms for AFM studies. The periodicity and arrangement of the designed nanostructures is determined by the size of the colloidal particles used for surface masks. Data processing is required to obtain images and topography information from raw AFM …


Addressing Agency In Intersectional Leadership: The Consequences Of Agentic Leader Behaviors For Black And White Men And Women In Leadership, Sydney Roux Dec 2024

Addressing Agency In Intersectional Leadership: The Consequences Of Agentic Leader Behaviors For Black And White Men And Women In Leadership, Sydney Roux

LSU Master's Theses

As Black women gain representation in business and entrepreneurial leadership, it is important to consider how these women will be perceived as leaders. Role congruity theory (RCT) posits that women’s gender roles do not align with the leadership role which often negatively impacts leader evaluations. However, RCT is often employed without a racial context where women are presumed to be White, and thus, it is unclear if the same assumptions can be applied to Black women. Leadership scholars have identified the ways in which attributions and expectations of leaders are shaped by both demographic characteristics and behavioral events. Because Black …


Carbon Dioxide Fluxes And The Dominant Role Of Vegetation In Recently Created And Reference Gulf Coast Marshes, A. Muench, T. Elsey-Quirk, J. R. White, R. D. Delaune Dec 2024

Carbon Dioxide Fluxes And The Dominant Role Of Vegetation In Recently Created And Reference Gulf Coast Marshes, A. Muench, T. Elsey-Quirk, J. R. White, R. D. Delaune

Faculty Publications

Coastal wetlands are one of the most productive ecosystems on Earth with the capacity to sequester large amounts of carbon dioxide (CO2). Wetland loss due to anthropogenic and natural causes reduces the carbon (C) storage capacity and potentially releases previously fixed C in biomass and soil to the water column and atmosphere through decomposition. Coastal wetland restoration has the potential to mitigate some of the C losses depending on the balance of C fluxes. However, the role of vegetation and environmental conditions in governing rates of C accumulation in restoration sites is not well resolved. The purpose of this study …


Net Evaporation-Induced Mangrove Area Loss Across Low-Lying Caribbean Islands, Isamar M. Cortés, Jorge Lorenzo-Trueba, Andre S. Rovai, Robert R. Twilley, Mark Chopping, Temilola Fatoyinbo Dec 2024

Net Evaporation-Induced Mangrove Area Loss Across Low-Lying Caribbean Islands, Isamar M. Cortés, Jorge Lorenzo-Trueba, Andre S. Rovai, Robert R. Twilley, Mark Chopping, Temilola Fatoyinbo

Faculty Publications

Although mangroves provide many beneficial ecosystem services, such as blue carbon storage and coastal protection, they are currently under threat due to changes in climate conditions, such as prolonged drought exposure. Under drought conditions, evaporation exceeds precipitation and high soil salinities can lead to stunted growth and die-back. To quantify this interplay, we developed a database for low-lying and uninhabited mangrove islands in the Caribbean under various evaporation and precipitation regimes. We extracted physical and biological information from each island using remote sensing techniques and coupled it with a process-based model. We used this database to develop a model that …


A Temperature Tipping Point In Hypoxic Zone Size, R. Eugene Turner, Nancy N. Rabalais, Cassandra N. Glaspie Dec 2024

A Temperature Tipping Point In Hypoxic Zone Size, R. Eugene Turner, Nancy N. Rabalais, Cassandra N. Glaspie

Faculty Publications

Temperature increases will have ubiquitous effects on aquatic food webs, from microbes to consumers, and affect the quality and quantity of carbon flows within and between water layers. A decline in the biological pump moving carbon from surface to lower layers is anticipated. We reviewed 37 years of data on hypoxic zone size and water quality in the northern Gulf of Mexico to determine if air and bottom water temperature increases (0.5°C decade−1) are significantly related to variations in its areal size. There was no significant decline in important river water quality in the 24 years since the …


Detecting, Attributing, And Projecting Global Marine Ecosystem And Fisheries Change: Fishmip 2.0, Julia L. Blanchard, Camilla Novaglio, Olivier Maury, Cheryl S. Harrison, Colleen M. Petrik, Denisse Fierro-Arcos, Kelly Ortega-Cisneros, Andrea Bryndum-Buchholz, Tyler D. Eddy, Ryan Heneghan, Kelsey Roberts, Jacob Schewe, Daniele Bianchi, Jerome Guiet, P. Daniel Van Denderen, Juliano Palacios-Abrantes, Xiao Liu, Charles A. Stock, Yannick Rousseau, Matthias Büchner, Ezekiel O. Adekoya, Cathy Bulman, William Cheung, Villy Christensen, Marta Coll, Leonardo Capitani, Samik Datta, Elizabeth A. Fulton, Alba Fuster, Victoria Garza, Matthieu Lengaigne, Max Lindmark, Kieran Murphy Dec 2024

Detecting, Attributing, And Projecting Global Marine Ecosystem And Fisheries Change: Fishmip 2.0, Julia L. Blanchard, Camilla Novaglio, Olivier Maury, Cheryl S. Harrison, Colleen M. Petrik, Denisse Fierro-Arcos, Kelly Ortega-Cisneros, Andrea Bryndum-Buchholz, Tyler D. Eddy, Ryan Heneghan, Kelsey Roberts, Jacob Schewe, Daniele Bianchi, Jerome Guiet, P. Daniel Van Denderen, Juliano Palacios-Abrantes, Xiao Liu, Charles A. Stock, Yannick Rousseau, Matthias Büchner, Ezekiel O. Adekoya, Cathy Bulman, William Cheung, Villy Christensen, Marta Coll, Leonardo Capitani, Samik Datta, Elizabeth A. Fulton, Alba Fuster, Victoria Garza, Matthieu Lengaigne, Max Lindmark, Kieran Murphy

Faculty Publications

There is an urgent need for models that can robustly detect past and project future ecosystem changes and risks to the services that they provide to people. The Fisheries and Marine Ecosystem Model Intercomparison Project (FishMIP) was established to develop model ensembles for projecting long-term impacts of climate change on fisheries and marine ecosystems while informing policy at spatio-temporal scales relevant to the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP) framework. While contributing FishMIP models have improved over time, large uncertainties in projections remain, particularly in coastal and shelf seas where most of the world's fisheries occur. Furthermore, previous FishMIP climate …


A Systematic Umbrella Review And Meta-Meta-Analysis Of Ehealth And Mhealth Interventions For Improving Lifestyle Behaviours, Ben Singh, Mavra Ahmed, Amanda E. Staiano, Claire Gough, Jasmine Petersen, Corneel Vandelanotte, Chelsea Kracht, Christopher Huong, Zenong Yin, Maria F. Vasiloglou, Chen Chia Pan, Camille E. Short, Matthew Mclaughlin, Lauren Von Klinggraeff, Christopher D. Pfledderer, Lisa J. Moran, Alyssa M. Button, Carol A. Maher Dec 2024

A Systematic Umbrella Review And Meta-Meta-Analysis Of Ehealth And Mhealth Interventions For Improving Lifestyle Behaviours, Ben Singh, Mavra Ahmed, Amanda E. Staiano, Claire Gough, Jasmine Petersen, Corneel Vandelanotte, Chelsea Kracht, Christopher Huong, Zenong Yin, Maria F. Vasiloglou, Chen Chia Pan, Camille E. Short, Matthew Mclaughlin, Lauren Von Klinggraeff, Christopher D. Pfledderer, Lisa J. Moran, Alyssa M. Button, Carol A. Maher

Population and Public Health Science Faculty Publications

The aim of this meta-meta-analysis was to systematically review randomised controlled trial (RCT) evidence examining the effectiveness of e- and m-Health interventions designed to improve physical activity, sedentary behaviour, healthy eating and sleep. Nine electronic databases were searched for eligible studies published from inception to 1 June 2023. Systematic reviews with meta-analyses of RCTs that evaluate e- and m-Health interventions designed to improve physical activity, sedentary behaviour, sleep and healthy eating in any adult population were included. Forty-seven meta-analyses were included, comprising of 507 RCTs and 206,873 participants. Interventions involved mobile apps, web-based and SMS interventions, with 14 focused on …


Multiomics Analysis To Explore Blood Metabolite Biomarkers In An Alzheimer’S Disease Neuroimaging Initiative Cohort, Takaki Oka, Yuki Matsuzawa, Momoka Tsuneyoshi, Yoshitaka Nakamura, Ken Aoshima, Hiroshi Tsugawa, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski Dec 2024

Multiomics Analysis To Explore Blood Metabolite Biomarkers In An Alzheimer’S Disease Neuroimaging Initiative Cohort, Takaki Oka, Yuki Matsuzawa, Momoka Tsuneyoshi, Yoshitaka Nakamura, Ken Aoshima, Hiroshi Tsugawa, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Clinical Research Faculty Publications

Alzheimer's disease (AD) is a neurodegenerative disease that commonly causes dementia. Identifying biomarkers for the early detection of AD is an emerging need, as brain dysfunction begins two decades before the onset of clinical symptoms. To this end, we reanalyzed untargeted metabolomic mass spectrometry data from 905 patients enrolled in the AD Neuroimaging Initiative (ADNI) cohort using MS-DIAL, with 1,304,633 spectra of 39,108 unique biomolecules. Metabolic profiles of 93 hydrophilic metabolites were determined. Additionally, we integrated targeted lipidomic data (4873 samples from 1524 patients) to explore candidate biomarkers for predicting progressive mild cognitive impairment (pMCI) in patients diagnosed with AD …


Correction To: Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review (Communications Medicine, (2023), 3, 1, (134), 10.1038/S43856-023-00368-9), Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel Dec 2024

Correction To: Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review (Communications Medicine, (2023), 3, 1, (134), 10.1038/S43856-023-00368-9), Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel

Clinical Research Faculty Publications

Correction to: Communications Medicinehttps://doi.org/10.1038/s43856-023-00368-9, published online 05 October 2023 The file Supplementary Data 3 was missing when this article was published. It has now been added and can be accessed via the Supplementary information section in the online version of the article. Citations to Supplementary Data 3 in the article remain unchanged.


Trajectories Of Offending Over 9 Years After Youths' First Arrest: What Predicts Who Desists And Who Continues To Offend?, Elizabeth Cauffman, Jordan Beardslee, Colleen Sbeglia, Paul J. Frick, Laurence Steinberg Dec 2024

Trajectories Of Offending Over 9 Years After Youths' First Arrest: What Predicts Who Desists And Who Continues To Offend?, Elizabeth Cauffman, Jordan Beardslee, Colleen Sbeglia, Paul J. Frick, Laurence Steinberg

Faculty Publications

Antisocial and illegal behavior generally declines as youth approach adulthood, but there is significant individual variation in the timing of the peak and decline of offending from adolescence to young adulthood. There are two primary research questions in the present study. First, are there subgroups of youth who follow similar patterns of offending over the nine years after their first arrest? Second, what baseline factors predict which youth will follow each pattern of offending? Data were drawn from the Crossroads study, which includes a sample of racially and ethnically diverse boys who were interviewed regularly for 9 years following their …


Estrogen Signaling In The Dorsal Raphe Regulates Binge-Like Drinking In Mice, Valeria C. Torres Irizarry, Bing Feng, Xiaohua Yang, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Hui Ye, Pei Luo, Leslie Carrillo-Sáenz, Penghua Lai, Maya Kota, Devin Dixit, Chunmei Wang, Amy W. Lasek, Yanlin He, Pingwen Xu Dec 2024

Estrogen Signaling In The Dorsal Raphe Regulates Binge-Like Drinking In Mice, Valeria C. Torres Irizarry, Bing Feng, Xiaohua Yang, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Hui Ye, Pei Luo, Leslie Carrillo-Sáenz, Penghua Lai, Maya Kota, Devin Dixit, Chunmei Wang, Amy W. Lasek, Yanlin He, Pingwen Xu

Division of Basic Science Faculty Publications

Estrogens promote binge alcohol drinking and contribute to sex differences in alcohol use disorder. However, the mechanisms are largely unknown. This study aims to test if estrogens act on 5-hydroxytryptamine neurons in the dorsal raphe nucleus (5-HTDRN) to promote binge drinking. We found that female mice drank more alcohol than male mice in chronic drinking in the dark (DID) tests. This sex difference was associated with distinct alterations in mRNA expression of estrogen receptor α (ERα) and 5-HT-related genes in the DRN, suggesting a potential role of estrogen/ERs/5-HT signaling. In supporting this view, 5-HTDRN neurons from naïve male mice had …


Exercise Therapy Rescues Skeletal Muscle Dysfunction And Exercise Intolerance In Cardiometabolic Hfpef, Heather Quiriarte, Robert C. Noland, James E. Stampley, Gregory Davis, Zhen Li, Eunhan Cho, Youyoung Kim, Jake Doiron, Guillaume Spielmann, Sujoy Ghosh, Sanjiv J. Shah, Brian A. Irving, David J. Lefer, Timothy D. Allerton Dec 2024

Exercise Therapy Rescues Skeletal Muscle Dysfunction And Exercise Intolerance In Cardiometabolic Hfpef, Heather Quiriarte, Robert C. Noland, James E. Stampley, Gregory Davis, Zhen Li, Eunhan Cho, Youyoung Kim, Jake Doiron, Guillaume Spielmann, Sujoy Ghosh, Sanjiv J. Shah, Brian A. Irving, David J. Lefer, Timothy D. Allerton

Division of Basic Science Faculty Publications

Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related to skeletal muscle metabolism. In a “2-hit” model of HFpEF, we investigated the ability of exercise therapy (voluntary wheel running) to reverse skeletal muscle dysfunction and exercise intolerance. Using state-of-the-art metabolic cages and a multiomic approach, we demonstrate exercise can rescue dysfunctional skeletal muscle lipid and branched-chain amino acid oxidation and restore exercise capacity in mice with cardiometabolic HFpEF. These results underscore the importance of skeletal muscle metabolism to improve exercise intolerance in HFpEF.


The Impact Of Exercise On Gene Regulation In Association With Complex Trait Genetics, Nikolai G. Vetr, Nicole R. Gay, Joshua N. Adkins, Brent G. Albertson, David Amar, Mary Anne S. Amper, Jose Juan Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Ali Tugrul Balci, Marcas Bamman, Nasim Bararpour, Elisabeth R. Barton, Pierre M. Jean Beltran, Bryan C. Bergman, Daniel H. Bessesen, Sue C. Bodine, Frank W. Booth, Brian Bouverat, Thomas W. Buford, Charles F. Burant, Tiziana Caputo, Steven Carr, Toby L. Chambers, Clarisa Chavez, Maria Chikina, Roxanne Chiu, Michael Cicha, Clary B. Clish, Paul M. Coen, Dan Cooper, Elaine Cornell, Gary Cutter Dec 2024

The Impact Of Exercise On Gene Regulation In Association With Complex Trait Genetics, Nikolai G. Vetr, Nicole R. Gay, Joshua N. Adkins, Brent G. Albertson, David Amar, Mary Anne S. Amper, Jose Juan Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Ali Tugrul Balci, Marcas Bamman, Nasim Bararpour, Elisabeth R. Barton, Pierre M. Jean Beltran, Bryan C. Bergman, Daniel H. Bessesen, Sue C. Bodine, Frank W. Booth, Brian Bouverat, Thomas W. Buford, Charles F. Burant, Tiziana Caputo, Steven Carr, Toby L. Chambers, Clarisa Chavez, Maria Chikina, Roxanne Chiu, Michael Cicha, Clary B. Clish, Paul M. Coen, Dan Cooper, Elaine Cornell, Gary Cutter

Clinical Research Faculty Publications

Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or easily biopsied tissues. Extensive transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium has provided a unique opportunity to clarify how exercise can affect tissue-specific gene expression and further suggest how exercise adaptation may impact complex disease-associated genes. To build this map, we integrate this multi-tissue atlas of gene expression changes with gene-disease …