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Elevated Corticosterone In Feathers Correlates With Corticosterone-Induced Decreased Feather Quality: A Validation Study, Christine R. Lattin, J. Michael Reed, David W. Desrochers, L. Michael Romero May 2011

Elevated Corticosterone In Feathers Correlates With Corticosterone-Induced Decreased Feather Quality: A Validation Study, Christine R. Lattin, J. Michael Reed, David W. Desrochers, L. Michael Romero

Faculty Publications

The newly described technique of extracting corticosterone (CORT) from bird feathers may serve as a less invasive, more integrated measure of a bird's stress response. Previous work indicated that elevated plasma CORT resulted in poorer quality feathers during molt. We tested the hypothesis that a direct link exists between plasma and feather CORT concentrations. We experimentally increased plasma CORT concentrations using implants and found that the corresponding rise in CORT could be detected in feathers grown during implantation. Furthermore, CORT levels in two feathers grown at the same time from the same bird were very consistent. These results provide evidence …

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Burkholderia Glumae: Next Major Pathogen Of Rice?, Jong Hyun Ham, Rebecca A. Melanson, Milton C. Rush May 2011

Burkholderia Glumae: Next Major Pathogen Of Rice?, Jong Hyun Ham, Rebecca A. Melanson, Milton C. Rush

Faculty Publications

Burkholderia glumae causes bacterial panicle blight of rice, which is an increasingly important disease problem in global rice production. Toxoflavin and lipase are known to be major virulence factors of this pathogen, and their production is dependent on the TofI/TofR quorum-sensing system, which is mediated by N-octanoyl homoserine lactone. Flagellar biogenesis and a type III secretion system are also required for full virulence of B. glumae. Bacterial panicle blight is thought to be caused by seed-borne B. glumae; however, its disease cycle is not fully understood. In spite of its economic importance, neither effective control measures for bacterial panicle blight …

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Template To Improve Glycemic Control Without Reducing Adiposity Or Dietary Fat, R. Krishnapuram, E. J. Dhurandhar, O. Dubuisson, H. Kirk-Ballard, S. Bajpeyi, N. Butte, M. S. Sothern, E. Larsen-Meyer, S. Chalew, B. Bennett, A. K. Gupta, F. L. Greenway, W. Johnson, M. Brashear, G. Reinhart, T. Rankinen, C. Bouchard, W. T. Cefalu, J. Ye, R. Javier, A. Zuberi, N. V. Dhurandhar May 2011

Template To Improve Glycemic Control Without Reducing Adiposity Or Dietary Fat, R. Krishnapuram, E. J. Dhurandhar, O. Dubuisson, H. Kirk-Ballard, S. Bajpeyi, N. Butte, M. S. Sothern, E. Larsen-Meyer, S. Chalew, B. Bennett, A. K. Gupta, F. L. Greenway, W. Johnson, M. Brashear, G. Reinhart, T. Rankinen, C. Bouchard, W. T. Cefalu, J. Ye, R. Javier, A. Zuberi, N. V. Dhurandhar

Faculty Publications

Drugs that improve chronic hyperglycemia independently of insulin signaling or reduction of adiposity or dietary fat intake may be highly desirable. Ad36, a human adenovirus, promotes glucose uptake in vitro independently of adiposity or proximal insulin signaling. We tested the ability of Ad36 to improve glycemic control in vivo and determined if the natural Ad36 infection in humans is associated with better glycemic control. C57BL/6J mice fed a chow diet or made diabetic with a high-fat (HF) diet were mock infected or infected with Ad36 or adenovirus Ad2 as a control for infection. Postinfection (pi), systemic glycemic control, hepatic lipid …

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A Tutorial Of Manual Segmentation Using The Visualization Program Avizo® As Illustrated By The Skeleton Of The Spiny Dogfish Shark, Squalus Acanthias, Mateusz A. Lapucha Apr 2011

A Tutorial Of Manual Segmentation Using The Visualization Program Avizo® As Illustrated By The Skeleton Of The Spiny Dogfish Shark, Squalus Acanthias, Mateusz A. Lapucha

Honors Capstones

No abstract provided.

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B Cell-Deficient Mice Display Markedly Enhanced Resistance To The Intracellular Bacterium Brucella Abortus, Radhika Goenka, Michelle A. Parent, Philip H. Elzer, Cynthia L. Baldwin Apr 2011

B Cell-Deficient Mice Display Markedly Enhanced Resistance To The Intracellular Bacterium Brucella Abortus, Radhika Goenka, Michelle A. Parent, Philip H. Elzer, Cynthia L. Baldwin

Faculty Publications

Background. Brucella species are facultative intracellular bacteria that cause lifelong infections in humans and livestock. Methods. Here we evaluated the contribution of B cells in control of murine brucellosis in the more susceptible BALB/c and the more resistant C57BL/6 mice by infecting B cell-deficient mice. Results. Strikingly, in the absence of B cells in both C57BL/6 and BALB/c mice, 99% and 99.5% of the infection found in wild type mice was cleared, respectively. This augmented clearance was not reversed in either strain by passive transfer of immune serum. In C57BL/6 mice, the clearance of infection coincided with an increase in …

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Rex1/Zfp42 As An Epigenetic Regulator For Genomic Imprinting, Jeong Do Kim, Hana Kim, Muhammad B. Ekram, Sungryul Yu, Christopher Faulk, Joomyeong Kim Apr 2011

Rex1/Zfp42 As An Epigenetic Regulator For Genomic Imprinting, Jeong Do Kim, Hana Kim, Muhammad B. Ekram, Sungryul Yu, Christopher Faulk, Joomyeong Kim

Faculty Publications

Zfp42/Rex1 (reduced expression gene 1) is a well-known stem-cell marker that has been duplicated from YY1 in the eutherian lineage. In the current study, we characterized the in vivo roles of Rex1 using a mutant mouse line disrupting its transcription. In contrast to the ubiquitous expression of YY1, Rex1 is expressed only during spermatogenesis and early embryogenesis and also in a very limited area of the placenta. Yet, the gene dosage of Rex1 is very critical for the survival of the late-stage embryos and neonates. This delayed phenotypic consequence suggests potential roles for Rex1 in establishing and maintaining unknown epigenetic …

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S11rs Sgfb No. 10 (Vet, Savma), Nipper, Scott, Abshire Apr 2011

S11rs Sgfb No. 10 (Vet, Savma), Nipper, Scott, Abshire

Student Senate Enrolled Legislation

No abstract provided.

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F10rs Sgb No. 1 (Election Code), Bonvillain, Alexander, Elmore, B Jones, D Jones, Lemoine, Vaughn, Wells Apr 2011

F10rs Sgb No. 1 (Election Code), Bonvillain, Alexander, Elmore, B Jones, D Jones, Lemoine, Vaughn, Wells

Student Senate Enrolled Legislation

No abstract provided.

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Faculty Senate Newsletter, April 2011, Louisiana State University And Agricultural & Mechanical College Apr 2011

Faculty Senate Newsletter, April 2011, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Message from President: In my last “welcome” column, I addressed the question of Louisiana universities after the economic crisis, suggesting a variety of adjustments that would increase morale and promote economic justice in institutions that reward fashion and momentary stellar performances more often than they recognize adventurous dissent or long-term projects. Although not inexhaustible, the topic of higher education after our present calamities merits a bit more consideration, especially with regard to structural changes that might advance our institution even in the midst of economic distress. Having commenced its career as the cultural equivalent of a fortification, LSU has always …

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The Sacrum Of The Poole-Rose Ossuary: Health Status, Variation, And Demography, Elizabeth A. Moffett Apr 2011

The Sacrum Of The Poole-Rose Ossuary: Health Status, Variation, And Demography, Elizabeth A. Moffett

Honors Capstones

No abstract provided.

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Louisiana Agriculture Spring, 2011, Lsu Agcenter Apr 2011

Louisiana Agriculture Spring, 2011, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

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Environmentally Persistent Free Radicals Decrease Cardiac Function Before And After Ischemia/Reperfusion Injury In Vivo, Kevin Lord, David Moll, John K. Lindsey, Sarah Mahne, Girija Raman, Tammy Dugas, Stephania Cormier, Dana Troxlair, Slawo Lomnicki, Barry Dellinger, Kurt Varner Apr 2011

Environmentally Persistent Free Radicals Decrease Cardiac Function Before And After Ischemia/Reperfusion Injury In Vivo, Kevin Lord, David Moll, John K. Lindsey, Sarah Mahne, Girija Raman, Tammy Dugas, Stephania Cormier, Dana Troxlair, Slawo Lomnicki, Barry Dellinger, Kurt Varner

Faculty Publications

Exposure to airborne particles is associated with increased cardiovascular morbidity and mortality. During the combustion of chlorine-containing hazardous materials and fuels, chlorinated hydrocarbons chemisorb to the surface of transition metal-oxide-containing particles, reduce the metal, and form an organic free radical. These radical-particle systems can survive in the environment for days and are called environmentally persistent free radicals (EPFRs). This study determined whether EPFRs could decrease left ventricular function before and after ischemia and reperfusion (I/R) in vivo. Male Brown-Norway rats were dosed (8mg/kg, intratracheal) 24h prior to testing with particles containing the EPFR of 1, 2-dichlorobenzene (DCB230). DCB230 treatment decreased …

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Skeletal Muscle Mitochondrial Capacity And Insulin Resistance In Type 2 Diabetes, Sudip Bajpeyi, Magdalena Pasarica, Cedric Moro, Kevin Conley, Sharon Jubrias, Olga Sereda, David H. Burk, Zhengyu Zhang, Alok Gupta, Lise Kjems, Steven R. Smith Apr 2011

Skeletal Muscle Mitochondrial Capacity And Insulin Resistance In Type 2 Diabetes, Sudip Bajpeyi, Magdalena Pasarica, Cedric Moro, Kevin Conley, Sharon Jubrias, Olga Sereda, David H. Burk, Zhengyu Zhang, Alok Gupta, Lise Kjems, Steven R. Smith

Faculty Publications

Objective: The objective of this study was to determine the role of maximum mitochondrial capacity on the variation in insulin sensitivity within a population of patients with type 2 diabetes mellitus (T2DM). Research Design and Methods: Fifty-eight participants enrolled in a cross-sectional design: eight active controls [maximum aerobic capacity (VO2max) . 40 ml/kg . min], 17 healthy sedentary controlswithout a family history (FH-) and seven with a family history (FH+) of diabetes, four obese participants, and 21 patients with T2DM. Mitochondrial capacity was measured noninvasively using 31P magnetic resonance spectroscopy of the vastus lateralis. Maximal ATP synthetic rate (ATPmax) was …

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S11rs Sgfb No. 7 (Pref-Vet), Nipper Apr 2011

S11rs Sgfb No. 7 (Pref-Vet), Nipper

Student Senate Enrolled Legislation

No abstract provided.

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Nuclear Versus Mitochondrial Dna: Evidence For Hybridization In Colobine Monkeys, Christian Roos, Dietmar Zinner, Laura S. Kubatko, Christiane Schwarz, Mouyu Yang, Dirk Meyer, Stephen D. Nash, Jinchuan Xing, Mark A. Batzer, Markus Brameier, Fabian H. Leendertz, Thomas Ziegler, Dyah Perwitasari-Farajallah, Tilo Nadler, Lutz Walter, Martin Osterholz Mar 2011

Nuclear Versus Mitochondrial Dna: Evidence For Hybridization In Colobine Monkeys, Christian Roos, Dietmar Zinner, Laura S. Kubatko, Christiane Schwarz, Mouyu Yang, Dirk Meyer, Stephen D. Nash, Jinchuan Xing, Mark A. Batzer, Markus Brameier, Fabian H. Leendertz, Thomas Ziegler, Dyah Perwitasari-Farajallah, Tilo Nadler, Lutz Walter, Martin Osterholz

Faculty Publications

Background: Colobine monkeys constitute a diverse group of primates with major radiations in Africa and Asia. However, phylogenetic relationships among genera are under debate, and recent molecular studies with incomplete taxon-sampling revealed discordant gene trees. To solve the evolutionary history of colobine genera and to determine causes for possible gene tree incongruences, we combined presence/absence analysis of mobile elements with autosomal, X chromosomal, Y chromosomal and mitochondrial sequence data from all recognized colobine genera. Results: Gene tree topologies and divergence age estimates derived from different markers were similar, but differed in placing Piliocolobus/Procolobus and langur genera among colobines. Although insufficient …

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Stem Cell Factor And Granulocyte Colony-Stimulating Factor Reduce Β-Amyloid Deposits In The Brains Of App/Ps1 Transgenic Mice, Bin Li, Maria E. Gonzalez-Toledo, Chun Shu Piao, Allen Gu, Roger E. Kelley, Li Ru Zhao Mar 2011

Stem Cell Factor And Granulocyte Colony-Stimulating Factor Reduce Β-Amyloid Deposits In The Brains Of App/Ps1 Transgenic Mice, Bin Li, Maria E. Gonzalez-Toledo, Chun Shu Piao, Allen Gu, Roger E. Kelley, Li Ru Zhao

Faculty Publications

Introduction. Alzheimer's disease (AD) is widely recognized as a serious public health problem and heavy financial burden. Currently, there is no treatment that can delay or stop the progressive brain damage in AD. Recently, we demonstrated that stem cell factor (SCF) in combination with granulocyte colony-stimulating factor (G-CSF) (SCF+G-CSF) has therapeutic effects on chronic stroke. The purpose of the present study is to determine whether SCF+G-CSF can reduce the burden of β-amyloid deposits in a mouse model of AD. Methods. APP/PS1 transgenic mice were used as the model of AD. To track bone marrow-derived cells in the brain, the bone …

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Expression And Localization Of Clc Chloride Transport Proteins In The Avian Retina, Emily Mcmains, Vijai Krishnan, Sujitha Prasad, Evanna Gleason Mar 2011

Expression And Localization Of Clc Chloride Transport Proteins In The Avian Retina, Emily Mcmains, Vijai Krishnan, Sujitha Prasad, Evanna Gleason

Faculty Publications

Members of the ubiquitously expressed CLC protein family of chloride channels and transporters play important roles in regulating cellular chloride and pH. The CLCs that function as Cl-/H+ antiporters, ClCs 3-7, are essential in particular for the acidification of endosomal compartments and protein degradation. These proteins are broadly expressed in the nervous system, and mutations that disrupt their expression are responsible for several human genetic diseases. Furthermore, knock-out of ClC3 and ClC7 in the mouse result in the degeneration of the hippocampus and the retina. Despite this evidence of their importance in retinal function, the expression patterns of different CLC …

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Environmentally Persistent Free Radicals Induce Airway Hyperresponsiveness In Neonatal Rat Lungs, Shrilatha Balakrishna, Jordy Saravia, Paul Thevenot, Terry Ahlert, Slawo Lominiki, Barry Dellinger, Stephania A. Cormier Mar 2011

Environmentally Persistent Free Radicals Induce Airway Hyperresponsiveness In Neonatal Rat Lungs, Shrilatha Balakrishna, Jordy Saravia, Paul Thevenot, Terry Ahlert, Slawo Lominiki, Barry Dellinger, Stephania A. Cormier

Faculty Publications

Background: Increased asthma risk/exacerbation in children and infants is associated with exposure to elevated levels of ultrafine particulate matter (PM). The presence of a newly realized class of pollutants, environmentally persistent free radicals (EPFRs), in PM from combustion sources suggests a potentially unrecognized risk factor for the development and/or exacerbation of asthma.Methods: Neonatal rats (7-days of age) were exposed to EPFR-containing combustion generated ultrafine particles (CGUFP), non-EPFR containing CGUFP, or air for 20 minutes per day for one week. Pulmonary function was assessed in exposed rats and age matched controls. Lavage fluid was isolated and assayed for cellularity and cytokines …

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Membrane Voltage Fluctuations Reduce Spike Frequency Adaptation And Preserve Output Gain In Ca1 Pyramidal Neurons In A High-Conductance State., Fernandez Fr, Broicher T, Truong A, White Ja Mar 2011

Membrane Voltage Fluctuations Reduce Spike Frequency Adaptation And Preserve Output Gain In Ca1 Pyramidal Neurons In A High-Conductance State., Fernandez Fr, Broicher T, Truong A, White Ja

Faculty Publications

No abstract provided.

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Marr Homologs With Urate-Binding Signature, Inoka C. Perera, Anne Grove Mar 2011

Marr Homologs With Urate-Binding Signature, Inoka C. Perera, Anne Grove

Faculty Publications

Bacteria that associate with living hosts require intricate mechanisms to detect and respond to host defenses. Part of the early host defense against invading bacteria is the production of reactive oxygen species, and xanthine oxidase is one of the main producers of such agents. The end-product of the enzymatic activity of xanthine oxidase, urate, was previously shown to be the natural ligand for Deinococcus radiodurans-encoded HucR and it was shown to attenuate DNA binding by Agrobacterium tumefaciens-encoded PecS and Burkholderia thailandensis-encoded MftR, all members of the multiple antibiotic resistance regulator (MarR) family. We here show that residues involved in binding …

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Faculty Senate Newsletter, March 2011, Louisiana State University And Agricultural & Mechanical College Mar 2011

Faculty Senate Newsletter, March 2011, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Message from President: Few would doubt that LSU and Louisiana higher education have made enormous progress over the last thirty-odd years. The notion that history progresses and that institutions advance has been out-of-fashion for aeons, yet it does seem that the onetime Old War Skule and its cohort campuses are doing a lot more in a much better way than they did at their inceptions. Sustaining the linear if not altogether teleological progress of Louisiana higher education, however, is the boom-and-bust cycle of the Louisiana economy, a cycle driven by the price of and demand for natural resources and related …

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Oral Treatment Of Rodents With Insecticides For Control Of Sand Flies (Diptera: Psychodidae) And The Fluorescent Tracer Technique (Ftt) As A Tool To Evaluate Potential Sand Fly Control Methods, T. M. Mascari, J. Clark, S. Gordon, M. A. Mitchell, E. D. Rowton, R. Stout, L. D. Foil Mar 2011

Oral Treatment Of Rodents With Insecticides For Control Of Sand Flies (Diptera: Psychodidae) And The Fluorescent Tracer Technique (Ftt) As A Tool To Evaluate Potential Sand Fly Control Methods, T. M. Mascari, J. Clark, S. Gordon, M. A. Mitchell, E. D. Rowton, R. Stout, L. D. Foil

Faculty Publications

In laboratory studies, insecticides (diflubenzuron, novaluron, methoprene and, pyriproxyfen) that have been incorporated into rodent diets were effective as feed-throughs against sand fly larvae. Novaluron also was effective against sand fly larvae at low concentrations and under simulated field conditions. Ivermectin has been shown to be effective as a systemic insecticide, killing 100% of blood-feeding sand flies for up to seven d after rodents were treated. The fluorescent tracer technique (FTT) is the use of certain fluorescent dyes (rhodamine B or uranine O) as feed-through transtadial biomarkers for phlebotomine sand flies, systemic biomarkers for blood-feeding sand flies, and permanent markers …

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Generation Of Trophoblast Stem Cells From Rabbit Embryonic Stem Cells With Bmp4, Tao Tan, Xianghui Tang, Jing Zhang, Yuyu Niu, Hongwei Chen, Bin Li, Qiang Wei, Weizhi Ji Mar 2011

Generation Of Trophoblast Stem Cells From Rabbit Embryonic Stem Cells With Bmp4, Tao Tan, Xianghui Tang, Jing Zhang, Yuyu Niu, Hongwei Chen, Bin Li, Qiang Wei, Weizhi Ji

Faculty Publications

Trophoblast stem (TS) cells are ideal models to investigate trophectoderm differentiation and placental development. Herein, we describe the derivation of rabbit trophoblast stem cells from embryonic stem (ES) cells. Rabbit ES cells generated in our laboratory were induced to differentiate in the presence of BMP4 and TS-like cell colonies were isolated and expanded. These cells expressed the molecular markers of mouse TS cells, were able to invade, give rise to derivatives of TS cells, and chimerize placental tissues when injected into blastocysts. The rabbit TS-like cells maintained self-renewal in culture medium with serum but without growth factors or feeder cells, …

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Evidence For Mesenchymal-Epithelial Transition Associated With Mouse Hepatic Stem Cell Differentiation, Bin Li, Yun Wen Zheng, Yuuki Sano, Hideki Taniguchi Feb 2011

Evidence For Mesenchymal-Epithelial Transition Associated With Mouse Hepatic Stem Cell Differentiation, Bin Li, Yun Wen Zheng, Yuuki Sano, Hideki Taniguchi

Faculty Publications

Mesenchymal-epithelial transition events are related to embryonic development, tissue construction, and wound healing. Stem cells are involved in all of these processes, at least in part. However, the direct evidence of mesenchymal-epithelial transition associated with stem cells is unclear. To determine whether mesenchymal-epithelial transition occurs in liver development and/or the differentiation process of hepatic stem cells in vitro, we analyzed a variety of murine liver tissues from embryonic day 11.5 to adults and the colonies derived from hepatic stem/progenitor cells isolated with flow cytometry. The results of gene expression, immunohistochemistry and Western blot showed that as liver develops, the expression …

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Lea Proteins During Water Stress: Not Just For Plants Anymore, Steven C. Hand, Michael A. Menze, Mehmet Toner, Leaf Boswell, Daniel Moore Feb 2011

Lea Proteins During Water Stress: Not Just For Plants Anymore, Steven C. Hand, Michael A. Menze, Mehmet Toner, Leaf Boswell, Daniel Moore

Faculty Publications

Late embryogenesis abundant (LEA) proteins are extremely hydrophilic proteins that were first identified in land plants. Intracellular accumulation is tightly correlated with acquisition of desiccation tolerance, and data support their capacity to stabilize other proteins and membranes during drying, especially in the presence of sugars like trehalose. Exciting reports now show that LEA proteins are not restricted to plants; multiple forms are expressed in desiccation-tolerant animals from at least four phyla. We evaluate here the expression, subcellular localization, biochemical properties, and potential functions of LEA proteins in animal species during water stress. LEA proteins are intrinsically unstructured in aqueous solution, …

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Faculty Senate Resolution 11-02, Louisiana State University And Agricultural & Mechanical College Feb 2011

Faculty Senate Resolution 11-02, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Faculty Senate Resolution on reissue of PS-29 as control in the course and classroom, adopted on February 15, 2011.

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A New Emoia Samoensis Group Lizard (Squamata: Scincidae) From The Cook Islands, South-Central Pacific, George R. Zug, Alison M. Hamilton, Christopher C. Austin Feb 2011

A New Emoia Samoensis Group Lizard (Squamata: Scincidae) From The Cook Islands, South-Central Pacific, George R. Zug, Alison M. Hamilton, Christopher C. Austin

Faculty Publications

The first published report of a large treeskink from Rarotonga, Cook Islands, appeared in 1988. The first museum voucher specimen was collected in 1984. Although this skink seems likely to be a recent arrival to the island of Rarotonga, it represents a unique member of the Emoia samoensis species group. We compare this population with other members of the E. samoensis group and describe the population as Emoia tuitarere n. sp., distinguished by a suite of external characters including SVL, number of dorsal scale rows, and number of subdigital lamellae of the fourth toe. We provide preliminary definitions for the …

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Isolation Of A Rickettsial Pathogen From A Non-Hematophagous Arthropod, Chutima Thepparit, Piyanate Sunyakumthorn, Mark L. Guillotte, Vsevolod L. Popov, Lane D. Foil, Kevin R. Macaluso Feb 2011

Isolation Of A Rickettsial Pathogen From A Non-Hematophagous Arthropod, Chutima Thepparit, Piyanate Sunyakumthorn, Mark L. Guillotte, Vsevolod L. Popov, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

Rickettsial diversity is intriguing in that some species are transmissible to vertebrates, while others appear exclusive to invertebrate hosts. Of particular interest is Rickettsia felis, identifiable in both stored product insect pests and hematophagous disease vectors. To understand rickettsial survival tactics in, and probable movement between, both insect systems will explicate the determinants of rickettsial pathogenicity. Towards this objective, a population of Liposcelis bostrychophila, common booklice, was successfully used for rickettsial isolation in ISE6 (tick-derived cells). Rickettsiae were also observed in L. bostrychophila by electron microscopy and in paraffin sections of booklice by immunofluorescence assay using anti-R. felis polyclonal antibody. …

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The Nlrp3 Inflammasome Instigates Obesity-Induced Inflammation And Insulin Resistance, Bolormaa Vandanmagsar, Yun Hee Youm, Anthony Ravussin, Jose E. Galgani, Krisztian Stadler, Randall L. Mynatt, Eric Ravussin, Jacqueline M. Stephens, Vishwa Deep Dixit Feb 2011

The Nlrp3 Inflammasome Instigates Obesity-Induced Inflammation And Insulin Resistance, Bolormaa Vandanmagsar, Yun Hee Youm, Anthony Ravussin, Jose E. Galgani, Krisztian Stadler, Randall L. Mynatt, Eric Ravussin, Jacqueline M. Stephens, Vishwa Deep Dixit

Faculty Publications

The emergence of chronic inflammation during obesity in the absence of overt infection or well-defined autoimmune processes is a puzzling phenomenon. The Nod-like receptor (NLR) family of innate immune cell sensors, such as the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (Nlrp3, but also known as Nalp3 or cryopyrin) inflammasome are implicated in recognizing certain nonmicrobial originated 'danger signals' leading to caspase-1 activation and subsequent interleukin-1β 2 (IL-1β 2) and IL-18 secretion. We show that calorie restriction and exercise-mediated weight loss in obese individuals with type 2 diabetes is associated with a reduction in adipose tissue expression of Nlrp3 as well …

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High-Throughput Cryopreservation Of Spermatozoa Of Blue Catfish (Ictalurus Furcatus): Establishment Of An Approach For Commercial-Scale Processing, E. Hu, Huiping Yang, Terrence R. Tiersch Feb 2011

High-Throughput Cryopreservation Of Spermatozoa Of Blue Catfish (Ictalurus Furcatus): Establishment Of An Approach For Commercial-Scale Processing, E. Hu, Huiping Yang, Terrence R. Tiersch

Faculty Publications

Hybrid catfish created by crossing of female channel catfish (Ictalurus punctatus) and male blue catfish (Ictalurus furcatus) are being used increasingly in foodfish aquaculture because of their fast growth and efficient food conversion. However, the availability of blue catfish males is limited, and their peak spawning is at a different time than that of the channel catfish. As such, cryopreservation of sperm of blue catfish could improve production of hybrid catfish, and has been studied in the laboratory and tested for feasibility in a commercial dairy bull cryopreservation facility. However, an approach for commercially relevant production of cryopreserved blue catfish …

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