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Progressive Cenozoic Cooling And The Demise Of Antarctica's Last Refugium, John B. Anderson, Sophie Warny, Rosemary A. Askin, Julia S. Wellner, Steven M. Bohaty, Alexandra E. Kirshner, Daniel N. Livsey, Alexander R. Simms, Tyler R. Smith, Werner Ehrmann, Lawrence A. Lawver, David Barbeau, Sherwood W. Wise, Denise K. Kulhenek, Fred M. Weaver, Wojciech Majewski Jul 2011

Progressive Cenozoic Cooling And The Demise Of Antarctica's Last Refugium, John B. Anderson, Sophie Warny, Rosemary A. Askin, Julia S. Wellner, Steven M. Bohaty, Alexandra E. Kirshner, Daniel N. Livsey, Alexander R. Simms, Tyler R. Smith, Werner Ehrmann, Lawrence A. Lawver, David Barbeau, Sherwood W. Wise, Denise K. Kulhenek, Fred M. Weaver, Wojciech Majewski

Faculty Publications

The Antarctic Peninsula is considered to be the last region of Antarctica to have been fully glaciated as a result of Cenozoic climatic cooling. As such, it was likely the last refugium for plants and animals that had inhabited the continent since it separated from the Gondwana supercontinent. Drill cores and seismic data acquired during two cruises (SHALDRIL I and II) in the northernmost Peninsula region yield a record that, when combined with existing data, indicates progressive cooling and associated changes in terrestrial vegetation over the course of the past 37 million years. Mountain glaciation began in the latest Eocene …

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Oncolytic Herpes Simplex Virus 1 Encoding 15-Prostaglandin Dehydrogenase Mitigates Immune Suppression And Reduces Ectopic Primary And Metastatic Breast Cancer In Mice, Jason D. Walker, Inder Sehgal, Konstantin G. Kousoulas Jul 2011

Oncolytic Herpes Simplex Virus 1 Encoding 15-Prostaglandin Dehydrogenase Mitigates Immune Suppression And Reduces Ectopic Primary And Metastatic Breast Cancer In Mice, Jason D. Walker, Inder Sehgal, Konstantin G. Kousoulas

Faculty Publications

Oncolytic herpes simplex virus 1 (HSV-1) viruses armed with immunomodulatory transgenes have shown potential for enhanced antitumor therapy by overcoming tumor-based immune suppression and promoting antitumor effector cell development. Previously, we reported that the new oncolytic HSV-1 virus, OncSyn (OS), engineered to fuse tumor cells, prevented tumor growth and metastasis to distal organs in the 4T1/BALB/c immunocompetent breast cancer mouse model, suggesting the elicitation of antitumor immune responses (Israyelyan et al., Hum. Gen. Ther. 18:5, 2007, and Israyelyan et al., Virol. J. 5:68, 2008). The OSV virus was constructed by deleting the OS viral host shutoff gene (vhs; UL41) to …

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Regulation Of The Edwardsiella Ictaluri Type Iii Secretion System By Ph And Phosphate Concentration Through Esra, Esrb, And Esrc, Matthew L. Rogge, Ronald L. Thune Jul 2011

Regulation Of The Edwardsiella Ictaluri Type Iii Secretion System By Ph And Phosphate Concentration Through Esra, Esrb, And Esrc, Matthew L. Rogge, Ronald L. Thune

Faculty Publications

A recently described Edwardsiella ictaluri type III secretion system (T3SS) with functional similarity to the Salmonella pathogenicity island 2 T3SS is required for replication in channel catfish head-kidney-derived macrophages (HKDM) and virulence in channel catfish. Quantitative PCR and Western blotting identified low pH and phosphate limitation as conducive to expression of the E. ictaluri T3SS, growth conditions that mimic the phagosomal environment. Mutagenesis studies demonstrated that expression is under the control of the EsrAB two-component regulatory system. EsrB also induces upregulation of the AraC-type regulatory protein EsrC, which enhances expression of the EscB/EseG chaperone/effector operon in concert with EsrB and …

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Acquisition Of Rickettsia Felis By Cat Fleas During Feeding, Kathryn E. Reif, Michael T. Kearney, Lane D. Foil, Kevin R. Macaluso Jul 2011

Acquisition Of Rickettsia Felis By Cat Fleas During Feeding, Kathryn E. Reif, Michael T. Kearney, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

Evidence for horizontal routes of transmission for Rickettsia felis has come from detection of R. felis infection in vertebrates and multiple blood-feeding arthropods; however, infection of cat fleas, Ctenocephalides felis, during blood feeding has not been demonstrated. In this study, the ability of cat fleas to acquire R. felis through an infectious blood meal with subsequent vertical transmission was examined. Utilizing an artificial feeding system, Rickettsia-naive fleas were exposed to R. felis-infected blood meals and monitored for subsequent infection at weekly intervals for 4 weeks. At 7 days postexposure (dpe) ∼52% of fleas successfully acquired rickettsiae and R. felis DNA; …

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Altered Gene Expression And Spongiotrophoblast Differentiation In Placenta From A Mouse Model Of Diabetes In Pregnancy, J. M. Salbaum, C. Kruger, X. Zhang, N. Arbour Delahaye, G. Pavlinkova, D. H. Burk, C. Kappen Jul 2011

Altered Gene Expression And Spongiotrophoblast Differentiation In Placenta From A Mouse Model Of Diabetes In Pregnancy, J. M. Salbaum, C. Kruger, X. Zhang, N. Arbour Delahaye, G. Pavlinkova, D. H. Burk, C. Kappen

Faculty Publications

Aims/hypothesis: Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, e.g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental function, and sought to identify cellular and molecular abnormalities in diabetic placenta. Methods: Using a mouse model of diabetic pregnancy, placental gene expression was assayed at mid-gestation and cellular composition analysed at various stages. Genome-wide expression profiling was validated by quantitative PCR and tissue localisation studies were performed to identify cellular correlates of altered gene expression in diabetic …

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Transcriptional Profiles Uncover Aspergillus Flavus-Induced Resistance In Maize Kernels, Meng Luo, Robert L. Brown, Zhi Yuan Chen, Abebe Menkir, Jiujiang Yu, Deepak Bhatnagar Jul 2011

Transcriptional Profiles Uncover Aspergillus Flavus-Induced Resistance In Maize Kernels, Meng Luo, Robert L. Brown, Zhi Yuan Chen, Abebe Menkir, Jiujiang Yu, Deepak Bhatnagar

Faculty Publications

Aflatoxin contamination caused by the opportunistic pathogen A. flavus is a major concern in maize production prior to harvest and through storage. Previous studies have highlighted the constitutive production of proteins involved in maize kernel resistance against A. flavus' infection. However, little is known about induced resistance nor about defense gene expression and regulation in kernels. In this study, maize oligonucleotide arrays and a pair of closely-related maize lines varying in aflatoxin accumulation were used to reveal the gene expression network in imbibed mature kernels in response to A. flavus' challenge. Inoculated kernels were incubated 72 h via the laboratory-based …

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Infectivity Period Of Mice Inoculated With Human Adenoviruses, Rashmi Krishnapuram, Heather Kirk-Ballard, Aamri Zuberi, Nikhil V. Dhurandhar Jun 2011

Infectivity Period Of Mice Inoculated With Human Adenoviruses, Rashmi Krishnapuram, Heather Kirk-Ballard, Aamri Zuberi, Nikhil V. Dhurandhar

Faculty Publications

Due to non-productive infections, mice are not a good model to study some human adenoviruses. However, mice provide an excellent model to study the metabolic effects of human adenovirus, Ad36. Research interest in Ad36 is increasing rapidly, and consequently an increase in the use of mice as a model is anticipated. However, little is known about the transmission potential of Ad36 from infected mice to other laboratory animals or personnel. While underestimating the infectivity could promote inadvertent spread of Ad36, overstating it could drain valuable laboratory resources and animals. Therefore, we determined the duration of infectivity in female C57BL/6J mice …

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Understory Bird Communities In Amazonian Rainforest Fragments: Species Turnover Through 25 Years Post-Isolation In Recovering Landscapes, Philip C. Stouffer, Erik I. Johnson, Richard O. Bierregaard, Thomas E. Lovejoy Jun 2011

Understory Bird Communities In Amazonian Rainforest Fragments: Species Turnover Through 25 Years Post-Isolation In Recovering Landscapes, Philip C. Stouffer, Erik I. Johnson, Richard O. Bierregaard, Thomas E. Lovejoy

Faculty Publications

Inferences about species loss following habitat conversion are typically drawn from short-term surveys, which cannot reconstruct long-term temporal dynamics of extinction and colonization. A long-term view can be critical, however, to determine the stability of communities within fragments. Likewise, landscape dynamics must be considered, as second growth structure and overall forest cover contribute to processes in fragments. Here we examine bird communities in 11 Amazonian rainforest fragments of 1-100 ha, beginning before the fragments were isolated in the 1980s, and continuing through 2007. Using a method that accounts for imperfect detection, we estimated extinction and colonization based on standardized mist-net …

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Intracellular Targeting Specificity Of Novel Phthalocyanines Assessed In A Host-Parasite Model For Developing Potential Photodynamic Medicine, Sujoy Dutta, Benson G. Ongarora, Hairong Li, Maria Graca H. Da Vicente, Bala K. Kolli, Kwang Poo Chang Jun 2011

Intracellular Targeting Specificity Of Novel Phthalocyanines Assessed In A Host-Parasite Model For Developing Potential Photodynamic Medicine, Sujoy Dutta, Benson G. Ongarora, Hairong Li, Maria Graca H. Da Vicente, Bala K. Kolli, Kwang Poo Chang

Faculty Publications

Photodynamic therapy, unlikely to elicit drug-resistance, deserves attention as a strategy to counter this outstanding problem common to the chemotherapy of all diseases. Previously, we have broadened the applicability of this modality to photodynamic vaccination by exploiting the unusual properties of the trypanosomatid protozoa, Leishmania, i.e., their innate ability of homing to the phagolysosomes of the antigen-presenting cells and their selective photolysis therein, using transgenic mutants endogenously inducible for porphyrin accumulation. Here, we extended the utility of this host-parasite model for in vitro photodynamic therapy and vaccination by exploring exogenously supplied photosensitizers. Seventeen novel phthalocyanines (Pcs) were screened in vitro …

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Hef1, A Novel Target Of Wnt Signaling, Promotes Colonic Cell Migration And Cancer Progression, Y. Li, J. H. Bavarva, Z. Wang, J. Guo, C. Qian, S. N. Thibodeau, E. A. Golemis, W. Liu Jun 2011

Hef1, A Novel Target Of Wnt Signaling, Promotes Colonic Cell Migration And Cancer Progression, Y. Li, J. H. Bavarva, Z. Wang, J. Guo, C. Qian, S. N. Thibodeau, E. A. Golemis, W. Liu

Faculty Publications

Misregulation of the canonical Wnt/Β-catenin pathway and aberrant activation of Wnt signaling target genes are common in colorectal cancer (CRC) and contribute to cancer progression. Altered expression of human enhancer of filamentation 1 (HEF1; also known as NEDD9 or Cas-L) has been implicated in progression of melanoma, breast, and CRC. However, the regulation of HEF1 and the role of HEF1 in CRC tumorigenesis are not fully understood. We here identify HEF1 as a novel Wnt signaling target. The expression of HEF1 was upregulated by Wnt-3a, Β-catenin, and Dvl2 in a dose-dependent manner, and was suppressed following Β-catenin downregulation by shRNA. …

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Vesicular Stomatitis Virus-Simian Retrovirus Type 2 Vaccine Protects Macaques From Detectable Infection And B-Cell Destruction, Rajeev Gautam, Arun Iyer, Meredith Hunter, Arpita Das, Tessa Williams, Jason Dufour, Cristian Apetrei, K. Gus Kousoulas, Preston A. Marx Jun 2011

Vesicular Stomatitis Virus-Simian Retrovirus Type 2 Vaccine Protects Macaques From Detectable Infection And B-Cell Destruction, Rajeev Gautam, Arun Iyer, Meredith Hunter, Arpita Das, Tessa Williams, Jason Dufour, Cristian Apetrei, K. Gus Kousoulas, Preston A. Marx

Faculty Publications

Natural infection with simian retrovirus (SRV) has long been recognized in rhesus macaques (RMs) and may result in an AIDS-like disease. Importantly, SRV infections persist as a problem in recently imported macaques. Therefore, there is a clear need to control SRV spread in macaque colonies. We developed a recombinant vesicular stomatitis virus (VSV)-SRV vaccine consisting of replication-competent hybrid VSVs that express SRV gag and env in separate vectors. The goal of this study was to assess the immunogenicity and protective efficacy of the VSV-SRV serotype 2 vaccine prime-boost approach in RMs. The VSV-SRV vector (expressing either SRV gag or env) …

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Reading Te Leaves: New Approaches To The Identification Of Transposable Element Insertions, David A. Ray, Mark A. Batzer Jun 2011

Reading Te Leaves: New Approaches To The Identification Of Transposable Element Insertions, David A. Ray, Mark A. Batzer

Faculty Publications

Transposable elements (TEs) are a tremendous source of genome instability and genetic variation. Of particular interest to investigators of human biology and human evolution are retrotransposon insertions that are recent and/or polymorphic in the human population. As a consequence, the ability to assay large numbers of polymorphic TEs in a given genome is valuable. Five recent manuscripts each propose methods to scan whole human genomes to identify, map, and, in some cases, genotype polymorphic retrotransposon insertions in multiple human genomes simultaneously. These technologies promise to revolutionize our ability to analyze human genomes for TE-based variation important to studies of human …

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Host Specificity Of Anthonomus Tenebrosus (Coleoptera: Curculionidae), A Potential Biological Control Agent Of Tropical Soda Apple (Solanaceae) In Florida, J. Medal, N. Bustamante, E. Bredow, H. Pedrosa, W. Overholt, R. Díaz, J. Cuda Jun 2011

Host Specificity Of Anthonomus Tenebrosus (Coleoptera: Curculionidae), A Potential Biological Control Agent Of Tropical Soda Apple (Solanaceae) In Florida, J. Medal, N. Bustamante, E. Bredow, H. Pedrosa, W. Overholt, R. Díaz, J. Cuda

Faculty Publications

Multiple-choice and no-choice tests were conducted at the Florida Department of Agriculture quarantine facility to determine the host specificity of the South American flower bud weevil, Anthonomus tenebrosus Boheman, intended for biological control of the exotic weed tropical soda apple (TSA), Solanum viarum Dunal in Florida, USA. Ninety-one plant species in 21 families were included in multiple-choice feeding and oviposition experiments, including the target weed and the 6 major cultivated Solanaceae: bell pepper (Capsicum annuum L.), chili pepper (C. frutescens L.), tomato (Lycopersicon esculentum Mill.), tobacco (Nicotiana tabacum L.), eggplant (Solanum melongena L.), and potato (Solanum tuberosum L.). Plant bouquets …

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Evaluation Of Juvenile Hormone Analogues As Rodent Feed-Through Insecticides For Control Of Immature Phlebotomine Sandflies, T. M. Mascari, M. A. Mitchell, E. D. Rowton, L. D. Foil Jun 2011

Evaluation Of Juvenile Hormone Analogues As Rodent Feed-Through Insecticides For Control Of Immature Phlebotomine Sandflies, T. M. Mascari, M. A. Mitchell, E. D. Rowton, L. D. Foil

Faculty Publications

The juvenile hormone analogues methoprene and pyriproxyfen were evaluated as rodent feed-through insecticides for control of immature stages of the sandfly Phlebotomus papatasi Scopoli (Diptera: Psychodidae). The development and survival of P. papatasi second-instar larvae fed faeces from Syrian hamsters, Mesocricetus auratus, that had been fed a diet containing methoprene (0, 9.788, 97.88 or 978.8 p.p.m.) or pyriproxyfen (0, 9.82, 98.2 or 982 p.p.m.) were evaluated. The faeces of methoprene-treated hamsters greatly reduced the percentage of larvae that pupated at all concentrations tested and prevented adult emergence at all but the lowest concentration (9.788 p.p.m.). Pyriproxyfen prevented both pupation and …

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Assessing The Risk Of Second Malignancies After Modern Radiotherapy, Wayne D. Newhauser, Marco Durante Jun 2011

Assessing The Risk Of Second Malignancies After Modern Radiotherapy, Wayne D. Newhauser, Marco Durante

Faculty Publications

Recent advances in radiotherapy have enabled the use of different types of particles, such as protons and heavy ions, as well as refinements to the treatment of tumours with standard sources (photons). However, the risk of second cancers arising in long-term survivors continues to be a problem. The long-term risks from treatments such as particle therapy have not yet been determined and are unlikely to become apparent for many years. Therefore, there is a need to develop risk assessments based on our current knowledge of radiation-induced carcinogenesis. © 2011 Macmillan Publishers Limited. All rights reserved.

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Convection Enhanced Delivery Of Carboranylporphyrins For Neutron Capture Therapy Of Brain Tumors, Shinji Kawabata, Weilian Yang, Rolf F. Barth, Gong Wu, Tianyao Huo, Peter J. Binns, Kent J. Riley, Owendi Ongayi, Vijay Gottumukkala, M. Graça H. Vicente Jun 2011

Convection Enhanced Delivery Of Carboranylporphyrins For Neutron Capture Therapy Of Brain Tumors, Shinji Kawabata, Weilian Yang, Rolf F. Barth, Gong Wu, Tianyao Huo, Peter J. Binns, Kent J. Riley, Owendi Ongayi, Vijay Gottumukkala, M. Graça H. Vicente

Faculty Publications

Boron neutron capture therapy (BNCT) is based on the nuclear capture and fission reactions that occur when non-radioactive 10B is irradiated with low energy thermal neutrons to produce α-particles ( 10B[n,α]7Li). Carboranylporphyrins are a class of substituted porphyrins containing multiple carborane clusters. Three of these compounds, designated H2TBP, H2TCP, and H2DCP, have been evaluated in the present study. The goals were two-fold. First, to determine their biodistribution following intracerebral (i.c.) administration by short term (30 min) convection enhanced delivery (CED) or sustained delivery over 24 h by Alzet™ osmotic pumps to F98 glioma bearing rats. Second, to determine the efficacy …

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Developing Resistance To Aflatoxin In Maize And Cottonseed, Jeffrey W. Cary, Kanniah Rajasekaran, Robert L. Brown, Meng Luo, Zhi Yuan Chen, Deepak Bhatnagar Jun 2011

Developing Resistance To Aflatoxin In Maize And Cottonseed, Jeffrey W. Cary, Kanniah Rajasekaran, Robert L. Brown, Meng Luo, Zhi Yuan Chen, Deepak Bhatnagar

Faculty Publications

At this time, no ''magic bullet'' for solving the aflatoxin contamination problem in maize and cottonseed has been identified, so several strategies must be utilized simultaneously to ensure a healthy crop, free of aflatoxins. The most widely explored strategy for the control of aflatoxin contamination is the development of preharvest host resistance. This is because A. flavus infects and produces aflatoxins in susceptible crops prior to harvest. In maize production, the host resistance strategy has gained prominence because of advances in the identification of natural resistance traits. However, native resistance in maize to aflatoxin contamination is polygenic and complex and, …

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Combined Admixture Mapping And Association Analysis Identifies A Novel Blood Pressure Genetic Locus On 5p13: Contributions From The Care Consortium, Xiaofeng Zhu, J. H. Young, Ervin Fox, Brendan J. Keating, Nora Franceschini, Sunjung Kang, Bamidele Tayo, Adebowale Adeyemo, Yun V. Sun, Yali Li, Alanna Morrison, Christopher Newton-Cheh, Kiang Liu, Santhi K. Ganesh, Abdullah Kutlar, Ramachandran S. Vasan, Albert Dreisbach, Sharon Wyatt, Joseph Polak, Walter Palmas, Solomon Musani, Herman Taylor, Richard Fabsitz, Raymond R. Townsend, Daniel Dries, Joseph Glessner, Charleston W.K. Chiang, Thomas Mosley, Sharon Kardia, David Curb, Joel N. Hirschhorn, Charles Rotimi, Alexander Reiner Jun 2011

Combined Admixture Mapping And Association Analysis Identifies A Novel Blood Pressure Genetic Locus On 5p13: Contributions From The Care Consortium, Xiaofeng Zhu, J. H. Young, Ervin Fox, Brendan J. Keating, Nora Franceschini, Sunjung Kang, Bamidele Tayo, Adebowale Adeyemo, Yun V. Sun, Yali Li, Alanna Morrison, Christopher Newton-Cheh, Kiang Liu, Santhi K. Ganesh, Abdullah Kutlar, Ramachandran S. Vasan, Albert Dreisbach, Sharon Wyatt, Joseph Polak, Walter Palmas, Solomon Musani, Herman Taylor, Richard Fabsitz, Raymond R. Townsend, Daniel Dries, Joseph Glessner, Charleston W.K. Chiang, Thomas Mosley, Sharon Kardia, David Curb, Joel N. Hirschhorn, Charles Rotimi, Alexander Reiner

Faculty Publications

Admixture mapping based on recently admixed populations is a powerful method to detect disease variants with substantial allele frequency differences in ancestral populations. We performed admixture mapping analysis for systolic blood pressure (SBP) and diastolic blood pressure (DBP), followed by trait-marker association analysis, in 6303 unrelated African-American participants of the Candidate Gene Association Resource (CARe) consortium. We identified five genomic regions (P < 0.001) harboring genetic variants contributing to inter-individual BP variation. In follow-up association analyses, correcting for all tests performed in this study, three loci were significantly associated with SBP and one significantly associated with DBP (P < 10-5). Further analyses suggested that six independent single-nucleotide polymorphisms (SNPs) contributed to the phenotypic variation observed in the admixture mapping analysis. These six SNPs were examined for replication in multiple, large, independent studies of African-Americans [Women's Health Initiative (WHI), Maywood, Genetic Epidemiology Network of Arteriopathy (GENOA) and Howard University Family Study (HUFS)] as well as one native African sample (Nigerian study), with a total replication sample size of 11 882. Meta-analysis of the replication set identified a novel variant (rs7726475) on chromosome 5 between the SUB1 and NPR3 genes, as being associated with SBP and DBP (P < 0.0015 for both); in meta-analyses combining the CARe samples with the replication data, we observed P-values of 4.45 × 10-7 for SBP and 7.52 × 10-7 for DBP for rs7726475 that were significant after accounting for all the tests performed. Our study highlights that admixture mapping analysis can help identify genetic variants missed by genomewide association studies because of drastically reduced number of tests in the whole genome. © The Author 2011. Published by Oxford University Press.

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Dynamics Of A Stochastic Predator-Prey Model With The Beddington-Deangelis Functional Response, Ta Viet Ton, Atsushi Yagi Jun 2011

Dynamics Of A Stochastic Predator-Prey Model With The Beddington-Deangelis Functional Response, Ta Viet Ton, Atsushi Yagi

Communications on Stochastic Analysis

No abstract provided.

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Preimplantation Factor (Pif) Correlates With Early Mammalian Embryo Development-Bovine And Murine Models, Christopher W. Stamatkin, Roumen G. Roussev, Mike Stout, Victor Absalon-Medina, Sivakumar Ramu, Chelsi Goodman, Carolyn B. Coulam, Robert O. Gilbert, Robert A. Godke, Eytan R. Barnea May 2011

Preimplantation Factor (Pif) Correlates With Early Mammalian Embryo Development-Bovine And Murine Models, Christopher W. Stamatkin, Roumen G. Roussev, Mike Stout, Victor Absalon-Medina, Sivakumar Ramu, Chelsi Goodman, Carolyn B. Coulam, Robert O. Gilbert, Robert A. Godke, Eytan R. Barnea

Faculty Publications

Background: PreImplantation Factor (PIF), a novel peptide secreted by viable embryos is essential for pregnancy: PIF modulates local immunity, promotes decidual pro-adhesion molecules and enhances trophoblast invasion. To determine the role of PIF in post-fertilization embryo development, we measured the peptide's concentration in the culture medium and tested endogenous PIF's potential trophic effects and direct interaction with the embryo.Methods: Determine PIF levels in culture medium of multiple mouse and single bovine embryos cultured up to the blastocyst stage using PIF-ELISA. Examine the inhibitory effects of anti-PIF-monoclonal antibody (mAb) added to medium on cultured mouse embryos development. Test FITC-PIF uptake by …

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Fire Ant Decapitating Fly Cooperative Release Programs (1994-2008): Two Pseudacteon Species, P. Tricuspis And P. Curvatus, Rapidly Expand Across Imported Fire Ant Populations In The Southeastern United States, Anne Marie A. Callcott, Sanford D. Porter, Ronald D. Weeks, L. C. Fudd Graham, Seth J. Johnson, Lawrence E. Gilbert May 2011

Fire Ant Decapitating Fly Cooperative Release Programs (1994-2008): Two Pseudacteon Species, P. Tricuspis And P. Curvatus, Rapidly Expand Across Imported Fire Ant Populations In The Southeastern United States, Anne Marie A. Callcott, Sanford D. Porter, Ronald D. Weeks, L. C. Fudd Graham, Seth J. Johnson, Lawrence E. Gilbert

Faculty Publications

Natural enemies of the imported fire ants, Solenopsis invicta Buren S. richteri Forel (Hymenoptera: Formicidae), and their hybrid, include a suite of more than 20 fire ant decapitating phorid flies from South America in the genus Pseudacteon. Over the past 12 years, many researchers and associates have cooperated in introducing several species as classical or self-sustaining biological control agents in the United States. As a result, two species of flies, Pseudacteon tricuspis Borgmeier and P. curvatus Borgmeier (Diptera: Phoridae), are well established across large areas of the southeastern United States. Whereas many researchers have published local and state information about …

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Gp130 Cytokines Exert Differential Patterns Of Crosstalk In Adipocytes Both In Vitro And In Vivo, Ursula A. White, William C. Stewart, Jacqueline M. Stephens May 2011

Gp130 Cytokines Exert Differential Patterns Of Crosstalk In Adipocytes Both In Vitro And In Vivo, Ursula A. White, William C. Stewart, Jacqueline M. Stephens

Faculty Publications

Glycoprotein 130 (Gp130) cytokines are involved in the regulation of numerous biological processes, including hematopoiesis, immune response, inflammation, cardiovascular action, and neuronal survival. These cytokines share gp130 as a common signal transducer in their receptor complex and typically activate signal transducer and activator of transcription (STAT) 3. Studies have shown that several gp130 cytokines have differential effects on both adipogenesis and insulin-stimulated glucose uptake. Yet, the complex interactions of these cytokines in adipose tissue have not been studied. Gp130 cytokines are differentially regulated in multiple tissues due to the presence of additional receptor components that are required for signaling, including …

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Faculty Senate Newsletter, May 2011, Louisiana State University And Agricultural & Mechanical College May 2011

Faculty Senate Newsletter, May 2011, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Message from President: Contradictions are easy to find. One need only listen to the prattle at the state capitol about workforce development and then look at the support for any step along the K–20 educational pilgrimage to find stark contrasts. It is simple enough to survey any campus, compare the actions against the capacities and against the habits of assorted administrators, and come to the conclusion that confusion, if not hypocrisy, rules the academic world. That recognition, along with the proverbial twenty-five cents, will get you the stirring stick for a far pricier coffee. The question that might be asked, …

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Forage Conservation Efficiency And Lactation Response To Bahiagrass Conserved As Barn-Stored Hay, Outdoor-Stored Hay, Or Baleage, M. E. Mccormick, K. J. Han, V. R. Moreira, D. C. Blouin, S. Forbes May 2011

Forage Conservation Efficiency And Lactation Response To Bahiagrass Conserved As Barn-Stored Hay, Outdoor-Stored Hay, Or Baleage, M. E. Mccormick, K. J. Han, V. R. Moreira, D. C. Blouin, S. Forbes

Faculty Publications

A study was conducted to determine the effect of conserving bahiagrass as outdoor-stored hay (OSH), barn-stored hay (BSH), or baleage (BAL) on storage losses and lactation performance by Holstein cows. For baleage production, bahiagrass forage was cut and allowed to dry for 20. h in windrows, baled (1.2×1.4. m), and individually wrapped with white stretch film. Forage cut on the same day was dried to hay stage, baled (1.2×1.6. m round bales), and stored either outdoors (OSH) or in an enclosed hay barn (BSH). Bales were core sampled and weighed at harvest and again following a 6-mo storage period. At …

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On The Cutting Edge: Post-Translational Modifications In Cytokinesis, K. Adam Bohnert, Kathleen L. Gould May 2011

On The Cutting Edge: Post-Translational Modifications In Cytokinesis, K. Adam Bohnert, Kathleen L. Gould

Faculty Publications

Cytokinesis represents the final stage in the cell cycle, in which two daughter cells, each with their complement of the duplicated genome, physically separate. At the core of this process sits highly conserved machinery responsible for specifying the plane of division, building a contractile apparatus and ultimately cleaving cells in two. Although the 'parts list' of contributing proteins has been well described, mechanisms by which these parts are spatially and temporally regulated are only beginning to be understood. With advancements in biochemical and proteomic analyses, recent work has uncovered multiple new roles for post-translational modifications in the regulation of cytokinesis. …

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Plexus: A New Model For New Orleans Public Healthcare, Jonathan Lejune May 2011

Plexus: A New Model For New Orleans Public Healthcare, Jonathan Lejune

Honors Capstones

No abstract provided.

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How Ordinary Objects Become Extraordinary: Artcurial And The Brancusi Sale, Marie Katherine Perret May 2011

How Ordinary Objects Become Extraordinary: Artcurial And The Brancusi Sale, Marie Katherine Perret

Honors Capstones

No abstract provided.

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Puritan Self-Examination Solitude And Relationship In The Devotional Literature Of The New England Puritans, Christine Pyle May 2011

Puritan Self-Examination Solitude And Relationship In The Devotional Literature Of The New England Puritans, Christine Pyle

Honors Capstones

No abstract provided.

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The Function And Mechanism Of Rrf-1 In Antiviral Rnai In C. Elegans, Amanda Lynn Callegan May 2011

The Function And Mechanism Of Rrf-1 In Antiviral Rnai In C. Elegans, Amanda Lynn Callegan

Honors Capstones

No abstract provided.

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Metabolic Restructuring During Energy-Limited States: Insights From Artemia Franciscana Embryos And Other Animals, Steven C. Hand, Michael A. Menze, Apu Borcar, Yuvraj Patil, Joseph A. Covi, Julie A. Reynolds, Mehmet Toner May 2011

Metabolic Restructuring During Energy-Limited States: Insights From Artemia Franciscana Embryos And Other Animals, Steven C. Hand, Michael A. Menze, Apu Borcar, Yuvraj Patil, Joseph A. Covi, Julie A. Reynolds, Mehmet Toner

Faculty Publications

Many life history stages of animals that experience environmental insults enter developmental arrested states that are characterized by reduced cellular proliferation, with or without a concurrent reduction in overall metabolism. In the case of the most profound metabolic arrest reported in invertebrates, i.e., anaerobic quiescence in Artemia franciscana embryos, acidification of the intracellular milieu is a major factor governing catabolic and anabolic downregulation. Release of ions from intracellular compartments is the source for approximately 50% of the proton equivalents needed for the 1.5 unit acidification that is observed. Recovery from the metabolic arrest requires re-sequestration of the protons with a …

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